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Controlling and synchronizing spatiotemporal chaos of the coupled Bragg acousto-optical bistable map system using nonlinear feedback 被引量:12
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作者 岳立娟 沈柯 《Chinese Physics B》 SCIE EI CAS CSCD 2005年第9期1760-1765,共6页
In this paper we present the control and synchronization of a coupled Bragg acousto-optic bistable map system using nonlinear feedback technology. This nonlinear feedback technology is useful to control a temporally c... In this paper we present the control and synchronization of a coupled Bragg acousto-optic bistable map system using nonlinear feedback technology. This nonlinear feedback technology is useful to control a temporally chaotic system as well as a spatiotemporally chaotic system. It can be extended to synchronize the spatiotemporal chaos. It can work in a wide range of the controlled and synchronized signals, so it can decrease the sensitivity down to a noise level. The synchronization can be obtained by the analysis of the largest conditional Lyapunov exponent spectrum, and easily implemented in practical systems just by adjusting the coupled strength without any pre-knowledge of the dynamic system required. 展开更多
关键词 synchronization and control spatiotemporal chaos nonlinear feedback acousto-optic bistable map system
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Variant Map System to Simulate Complex Properties of DNA Interactions Using Binary Sequences 被引量:1
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作者 Jeffrey Zheng Weiqiong Zhang +2 位作者 Jin Luo Wei Zhou Ruoyu Shen 《Advances in Pure Mathematics》 2013年第7期5-24,共20页
Stream cipher, DNA cryptography and DNA analysis are the most important R&D fields in both Cryptography and Bioinformatics. HC-256 is an emerged scheme as the new generation of stream ciphers for advanced network ... Stream cipher, DNA cryptography and DNA analysis are the most important R&D fields in both Cryptography and Bioinformatics. HC-256 is an emerged scheme as the new generation of stream ciphers for advanced network security. From a random sequencing viewpoint, both sequences of HC-256 and real DNA data may have intrinsic pseudo-random properties respectively. In a recent decade, many DNA sequencing projects are developed on cells, plants and animals over the world into huge DNA databases. Researchers notice that mammalian genomes encode thousands of large noncoding RNAs (lncRNAs), interact with chromatin regulatory complexes, and are thought to play a role in localizing these complexes to target loci across the genome. It is a challenge target using higher dimensional visualization tools to organize various complex interactive properties as visual maps. The Variant Map System (VMS) as an emerging scheme is systematically proposed in this paper to apply multiple maps that used four Meta symbols as same as DNA or RNA representations. System architecture of key components and core mechanism on the VMS are described. Key modules, equations and their I/O parameters are discussed. Applying the VM System, two sets of real DNA sequences from both sample human (noncoding DNA) and corn (coding DNA) genomes are collected in comparison with pseudo DNA sequences generated by HC-256 to show their intrinsic properties in higher levels of similar relationships among relevant DNA sequences on 2D maps. Sample 2D maps are listed and their characteristics are illustrated under controllable environment. Visual results are briefly analyzed to explore their intrinsic properties on selected genome sequences. 展开更多
关键词 PSEUDO-RANDOM Number Generator STREAM CIPHER HC-256 Binary to DNA Pseudo DNA Sequence Large Noncoding DNA Analysis 2D map Visual Distribution VARIANT map system
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Application of RgMap system on digital regional geological survey 被引量:2
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作者 Qingying ZHAO Jinxin HE +1 位作者 Guoliang WANG Xiumei HAN 《Global Geology》 2007年第1期95-99,共5页
Digital geological mapping fundamentally broke through the traditional working pattern,successfully carried out the geological mapping digitalization.By using the RGMAP system to field digital geological mapping,the a... Digital geological mapping fundamentally broke through the traditional working pattern,successfully carried out the geological mapping digitalization.By using the RGMAP system to field digital geological mapping,the authors summarized the method of work and the work flow of the RGMAPGIS during the field geological survey.First,we prepared material,set up the PRB gallery,then put the geographic base map under the background maplayer and organizing the field hand map,forming the field factual datum map.At last,the geological space database is formed. 展开更多
关键词 digital mapping PRB gallery factual datum map spatial database
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Mouse-Sensitive Following Path Suggestion for Drawing Travel Routes in Web Map Systems
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作者 Pablo Martinez Lerin Daisuke Yamamoto Naohisa Takahashi 《Journal of Geographic Information System》 2012年第5期393-402,共10页
This paper proposes a web map system for drawing an arbitrary travel route using a mouse-sensitive following path suggestion. The interaction model of the system allows users to intuitively understand the sequence of ... This paper proposes a web map system for drawing an arbitrary travel route using a mouse-sensitive following path suggestion. The interaction model of the system allows users to intuitively understand the sequence of user actions needed to draw a conceived route and reduces the number of user actions required. Moreover, the system allows users to understand at a glance several drawing alternatives (static suggestion) and also consider a particular drawing alternative (dynamic suggestion) without making any commitment. The proposed architecture of the system reduces the influence caused by communication delay between a map server and a web client by delivering in advance road network data from a map server to a web client. Experimental evaluations on a prototype we developed demonstrated that the proposed system enables users to draw arbitrary routes within noticeably less clicks, in less time, and with less stress than previous systems. 展开更多
关键词 COMPUTER-AIDED ROUTE DRAWING FOLLOWING PATH Web map system GIS
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A Comprehensive Literature Review of AI-Driven Application Mapping and Scheduling Techniques for Network-on-Chip Systems
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作者 Naveed Ahmad Muhammad Kaleem +5 位作者 Mourad Elloumi Muhammad Azhar Mushtaq Ahlem Fatnassi Mohd Fazil Anas Bilal Abdulbasit A.Darem 《Computer Modeling in Engineering & Sciences》 2026年第1期118-155,共38页
Network-on-Chip(NoC)systems are progressively deployed in connecting massively parallel megacore systems in the new computing architecture.As a result,application mapping has become an important aspect of performance ... Network-on-Chip(NoC)systems are progressively deployed in connecting massively parallel megacore systems in the new computing architecture.As a result,application mapping has become an important aspect of performance and scalability,as current trends require the distribution of computation across network nodes/points.In this paper,we survey a large number of mapping and scheduling techniques designed for NoC architectures.This time,we concentrated on 3D systems.We take a systematic literature review approach to analyze existing methods across static,dynamic,hybrid,and machine-learning-based approaches,alongside preliminary AI-based dynamic models in recent works.We classify them into several main aspects covering power-aware mapping,fault tolerance,load-balancing,and adaptive for dynamic workloads.Also,we assess the efficacy of each method against performance parameters,such as latency,throughput,response time,and error rate.Key challenges,including energy efficiency,real-time adaptability,and reinforcement learning integration,are highlighted as well.To the best of our knowledge,this is one of the recent reviews that identifies both traditional and AI-based algorithms for mapping over a modern NoC,and opens research challenges.Finally,we provide directions for future work toward improved adaptability and scalability via lightweight learned models and hierarchical mapping frameworks. 展开更多
关键词 Application mapping mapping techniques NETWORK-ON-CHIP system on chip optimisation
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基于Connectivity Map的药物重定位评价维拉帕米作为治疗帕金森病的药物
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作者 新吉乐 刘晶 +6 位作者 张欣翼 郭家缘 韩文卓 孙怡馨 赵乐 冯卫生 郑晓珂 《中国临床药理学与治疗学》 北大核心 2026年第1期14-27,共14页
目的:筛选调控帕金森病(Parkinson's disease,PD)发病关键基因及相关转录因子表达的小分子化合物。方法:分析PD患者的基因表达谱数据,筛选PD发病关键基因及转录因子。Connectivity Map(CMap)筛选可调控转录因子表达的小分子药物,并... 目的:筛选调控帕金森病(Parkinson's disease,PD)发病关键基因及相关转录因子表达的小分子化合物。方法:分析PD患者的基因表达谱数据,筛选PD发病关键基因及转录因子。Connectivity Map(CMap)筛选可调控转录因子表达的小分子药物,并在6-羟基多巴胺(6-OHDA)诱导损伤的PC12细胞和PD小鼠模型评价其PD治疗作用。结果:维拉帕米(verapamil,Ver)为潜在的候选药物。Ver对6-OHDA损伤的PC12细胞具有保护作用,同时对6-OHDA诱导的PAX5、LEF1、MTF1、IKZF3和SP140等转录因子,以及ITGA6、CDH1、CD40、ESR1、SMAD3、CXCR4等PD发病基因的表达具有调控作用。PD模型小鼠中,Ver可对α-突触核蛋白(α-Syn)表达有一定抑制作用,但对上述PD发病基因及其转录因子和调控作用较弱。结论:Ver对PD的治疗作用部分依赖于对PD发病基因及其相关转录因子的调控作用。 展开更多
关键词 帕金森病 转录因子 Connectivity map 维拉帕米 6-羟基多巴胺
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Native T1 mapping值显著延长心脏纤维瘤一例
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作者 文涛 张辉 +3 位作者 甘铁军 胡万均 李世兰 张静 《磁共振成像》 北大核心 2026年第1期120-122,共3页
本研究为回顾性研究,遵守《赫尔辛基宣言》,并经兰州大学第二医院伦理委员会审核批准,免除受试者知情同意,批准文号:2025A-547。患儿,女,2月8天,因“发现心脏肿瘤2月”于2024年11月就诊于我院,患儿于2个月前出生后外院检查提示左心室肿... 本研究为回顾性研究,遵守《赫尔辛基宣言》,并经兰州大学第二医院伦理委员会审核批准,免除受试者知情同意,批准文号:2025A-547。患儿,女,2月8天,因“发现心脏肿瘤2月”于2024年11月就诊于我院,患儿于2个月前出生后外院检查提示左心室肿瘤,未予特殊诊治,现为进一步明确诊治收住我院心脏外科。患儿足月(38+6周)、顺产、无心脏肿瘤家族史。查体:心前区无隆起,心界不大,心音有力、律齐,胸骨左缘第2~3肋间可闻及3/6及吹风样杂音,静息血氧饱和度100%。 展开更多
关键词 心脏肿瘤 心脏纤维瘤 多模态磁共振成像 心脏磁共振 Native T1 mapping
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T2 Mapping联合DWI序列评估直肠癌脉管侵犯价值研究
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作者 李茜玮 陈安良 +2 位作者 王楠 林良杰 刘爱连 《中国CT和MRI杂志》 2026年第1期149-152,共4页
目的探讨T2 mapping与DWI序列预测直肠癌脉管侵犯的价值。方法回顾性分析经本院行3.0T MRI扫描且经术后病理证实的直肠癌脉管侵犯13例,脉管非侵犯20例,2名观察者分别于瘤体显示最大层面参考增强动脉期图像及DWI图像于T2 mapping及ADC图... 目的探讨T2 mapping与DWI序列预测直肠癌脉管侵犯的价值。方法回顾性分析经本院行3.0T MRI扫描且经术后病理证实的直肠癌脉管侵犯13例,脉管非侵犯20例,2名观察者分别于瘤体显示最大层面参考增强动脉期图像及DWI图像于T2 mapping及ADC图像上测量病灶T2值及ADC值。采用组内相关系数(intraclass correlation cofficient,ICC)评估两名观察者测量参数值的一致性。采用独立样本t检验或Mann-Whitney U检验分析两组病例各参数的差异。采用Logistic回归计算有统计学差异的参数联合评估直肠癌LVI的预测值。采用ROC曲线评估有差异参数单独或联合的诊断效能,并利用De-Long检验比较各ROC曲线间的差异。采用Pearson相关性检验分析两参数值的相关性。结果2名观察者测量T2值及ADC值一致性好(ICC>0.75)。脉管侵犯组的T2值及ADC值低于非脉管侵犯组(77.15±6.95ms、0.69±0.15mm^(2)/s vs 87.04±7.75ms、0.90±0.21 mm^(2)/s,P<0.05)。ADC值与ADC-T2联合鉴别两组疾病的AUC值比较差异具有统计学意义(P=0.036)。结论T2 mapping和DWI序列可预测直肠癌脉管侵犯,两序列联合效能提升,因此T2值与ADC值联合可为临床诊疗直肠癌脉管侵犯提供参考信息。 展开更多
关键词 直肠癌 脉管侵犯 磁共振成像 T2 mapping成像 弥散加权成像
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Mapping bioclimatic units of Oaxaca in Mexico:A systematic assessment
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作者 Alejandro GONZÁLEZ-PÉREZ Gustavo RAMÍREZ-SANTIAGO +4 位作者 Yuri QUIROZ-ORTUÑO Alejandro VELAZQUEZ Sara DEL RÍO Jean F.MAS Ángel PENAS 《Journal of Mountain Science》 2025年第6期2083-2097,共15页
Bioclimatic classification(WBCS),which examines the relationship between vegetation distribution and climatic variables such as precipitation and temperature,is essential for understanding the ecological dynamics.This... Bioclimatic classification(WBCS),which examines the relationship between vegetation distribution and climatic variables such as precipitation and temperature,is essential for understanding the ecological dynamics.This research focuses on producing a detailed bioclimatic map of Oaxaca,Mexico,at a spatial resolution of 30 arc-seconds,using the methodology developed by Rivas-Martínez et al.(2011).Oaxaca,characterised by its complex topography and diverse climatic conditions,provides a unique opportunity to study bioclimatic patterns in a tropical region.Using high-resolution climate data from Chelsa database,we identified and mapped different bioclimates,variants,thermotypes and ombrotypes horizons and levels of continentality within the tropical macrobioclimate.Our analysis revealed a rich diversity of bioclimatic zones,reflecting the complex interplay between Oaxaca's physical geography and its bioclimates.The results,presented in high resolution maps,highlight the spatial variability and complexity of Oaxaca's bioclimatic landscape.These findings are crucial for several applications,including biodiversity conservation,agricultural planning and climate change adaptation strategies.By providing an accurate bioclimatic classification,this study makes a significant contribution to bioclimatology and could give valuable insights into climate-vegetation relationships in tropical regions.This detailed bioclimatic map improves our understanding of the current ecological status of Oaxaca and serves as a critical tool for future environmental planning and conservation efforts.Furthermore,it could be the basis for planning in national programs that consider agriculture and forests in Mexico such as Programa Sembrando Vida(PSV). 展开更多
关键词 Bioclimatic mapping Ecological planning Isobioclimate OAXACA Tropical macrobioclimate
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Evidence map of systematic reviews on acupuncture and moxibustion for prevention and management of cancer-related conditions
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作者 Xiao-yan LYU Xin-ru YUAN +16 位作者 Zi-yang FAN Jia-ni MA Chang-qi LI Xin-yang LI Hui ZHANG Li-yuan FU Bin-xu SUN Dan LI Xiao-hua WEN Tian-yi ZHAO Mei-dan ZHAO Yi-nan GONG Bin WANG Ao-xiang CHEN Yi GUO Shi-yan YAN Bo CHEN 《World Journal of Acupuncture-Moxibustion》 2025年第4期290-302,共13页
Objective:In this study,we evaluated the methodological quality of systematic reviews on acupuncture and moxibustion for the prevention and management of cancer-related conditions,aiming to provide evidence-based supp... Objective:In this study,we evaluated the methodological quality of systematic reviews on acupuncture and moxibustion for the prevention and management of cancer-related conditions,aiming to provide evidence-based support and establish levels of evidence for clinical application.Method:A comprehensive search was conducted to identify systematic reviews on acupuncture and mox-ibustion for the prevention and management of cancer-related conditions,covering databases including PubMed,Embase,Cochrane Library,Web of Science,China National Knowledge Infrastructure,Chinese Biomedical Databases,China Science and Technology Journal Database,and Wanfang Data,from their in-ception to August 1,2024.The methodological quality of the included systematic reviews was assessed by using AMSTAR 2,and bubble plots were employed to visualize the evidence.Results:Overall,137 systematic reviews were included,with China being the most prolific country,with 117 reviews.These reviews addressed 21 cancer-related conditions,with the three most frequently stud-ied being cancer-related fatigue(25 reviews),nausea and vomiting(20 reviews),and cancer pain(19 re-views).The three most commonly used acupuncture modalities were manual acupuncture(81 reviews),electroacupuncture(55 reviews),and moxibustion(39 reviews).Quality assessment revealed that one systematic review was rated as“high quality,”eight as“low quality,”and 128 as“critically low quality,”primarily due to the absence of protocol registration and lists of excluded studies.Conclusion:Acupuncture and moxibustion have shown potential efficacy in alleviating cancer-related con-ditions and treatment-related adverse effects,and their clinical use has been widely reported.However,the overall methodological quality of the included systematic reviews was low,limiting the reliability and the strength of the evidence.Future high-quality studies are needed to improve the quality of evidence and support the standardized application and broader promotion of acupuncture and moxibustion clinical practice. 展开更多
关键词 Acupuncture MOXIBUSTION Cancer-related conditions Evidence mapping systematic reviews AMSTAR 2 Clinical practice guidelines
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Efficient Bit-Plane Based Medical Image Cryptosystem Using Novel and Robust Sine-Cosine Chaotic Map
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作者 Zeric Tabekoueng Njitacke Louai A.Maghrabi +1 位作者 Musheer Ahmad Turki Althaqafi 《Computers, Materials & Continua》 2025年第4期917-933,共17页
This paper presents a high-security medical image encryption method that leverages a novel and robust sine-cosine map.The map demonstrates remarkable chaotic dynamics over a wide range of parameters.We employ nonlinea... This paper presents a high-security medical image encryption method that leverages a novel and robust sine-cosine map.The map demonstrates remarkable chaotic dynamics over a wide range of parameters.We employ nonlinear analytical tools to thoroughly investigate the dynamics of the chaotic map,which allows us to select optimal parameter configurations for the encryption process.Our findings indicate that the proposed sine-cosine map is capable of generating a rich variety of chaotic attractors,an essential characteristic for effective encryption.The encryption technique is based on bit-plane decomposition,wherein a plain image is divided into distinct bit planes.These planes are organized into two matrices:one containing the most significant bit planes and the other housing the least significant ones.The subsequent phases of chaotic confusion and diffusion utilize these matrices to enhance security.An auxiliary matrix is then generated,comprising the combined bit planes that yield the final encrypted image.Experimental results demonstrate that our proposed technique achieves a commendable level of security for safeguarding sensitive patient information in medical images.As a result,image quality is evaluated using the Structural Similarity Index(SSIM),yielding values close to zero for encrypted images and approaching one for decrypted images.Additionally,the entropy values of the encrypted images are near 8,with a Number of Pixel Change Rate(NPCR)and Unified Average Change Intensity(UACI)exceeding 99.50%and 33%,respectively.Furthermore,quantitative assessments of occlusion attacks,along with comparisons to leading algorithms,validate the integrity and efficacy of our medical image encryption approach. 展开更多
关键词 Image cryptosystem robust chaos sine-cosine map nonlinear analysis tools medical images
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基于网络药理学及动物实验探讨补阳还五汤通过miR-30e-5p调控MAP3K5治疗低氧性肺动脉高压作用机制
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作者 王凯心 秦一冰 曲妮妮 《辽宁中医药大学学报》 2026年第3期15-24,共10页
目的基于网络药理学与动物实验探讨补阳还五汤对低氧性肺动脉高压(hypoxic pulmonary hypertension,HPH)大鼠血管重构的影响及其作用机制。方法(1)网络药理学实验。使用TCMSP、HERB、GeneCards、OMIM以及UniProt等公共数据库,筛选补阳... 目的基于网络药理学与动物实验探讨补阳还五汤对低氧性肺动脉高压(hypoxic pulmonary hypertension,HPH)大鼠血管重构的影响及其作用机制。方法(1)网络药理学实验。使用TCMSP、HERB、GeneCards、OMIM以及UniProt等公共数据库,筛选补阳还五汤和肺动脉高压(pulmonary arterial hypertension,PAH)的靶点基因并标准化;进行蛋白互作(protein-protein interaction,PPI)网络以及基因本体论(gene ontology,GO)和京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)通路富集分析;制作靶点交集韦恩图和“药物-成分-靶点-疾病”网络图;建立miRNAs-mRNAs网络互作图。(2)动物实验。将SD雄性大鼠50只随机分成5组,分别为空白组、模型组、中药低剂量组、中药中剂量组及中药高剂量组,每组10只,使用低氧暴露法建立HPH大鼠模型。4周后检测各组大鼠右心室压力;免疫组化测定肺小动脉细胞核抗原(proliferating cell nuclear antigen,PCNA)的表达;ELISA法检测血清中P27^(kip1)的表达;Western blot法检测肺组织增殖、凋亡及通路相关蛋白的表达水平;实时定量逆转录聚合酶链反应(reverse transcription quantitative PCR,RT-qPCR)法检测各组大鼠肺组织中miR-30e-5p和丝裂原活化蛋白激酶激酶激酶5信号通路(mitogen-activated protein kinase kinase kinase 5 signaling pathway,MAP3K5)mRNA的表达。结果(1)网络药理学结果显示,补阳还五汤活性成分109个,相关靶点495个,疾病相关靶点7789个,交集靶点235个;GO功能富集分析共获得1038个条目,分别为生物过程(biological process,BP)774条、细胞组分(cellular component,CC)91条及分子功能(molecular function,MF)173条,KEGG富集结果175条;网络图分析出前5个主要疾病通路为肿瘤坏死因子(tumor necrosis factor,TNF)信号通路、白细胞介素-17(interleukin-17,IL-17)信号通路、晚期糖基化终末产物-其受体(advanced glycation end productsreceptor for AGE,AGE-RAGE)信号通路、MAP3K5和lipid and atherosclerosis信号通路;miRNAs-mRNAs网络互作图得出miR-30e-5p和MAP3K5关系密切。(2)与空白组相比,模型组右心室压力显著上升,肺小动脉结构改变;MAP3K5 mRNA及MAP3K5、B-细胞淋巴瘤2(B-cell lymphoma 2,Bcl-2)蛋白表达增加(P<0.01);miR-30e-5p mRNA及P27^(kip1)、细胞色素C(cytochrome C,Cyt C)、Bcl-2关联X蛋白(Bcl-2-associated X protein,Bax)、半胱天冬酶-3(Caspase-3)及半胱天冬酶-9(Caspase-9)蛋白表达降低(P<0.01);与模型组相比,中药各剂量组则显著降低了右心室压力,改善了肺小动脉结构,MAP3K5 mRNA及MAP3K5、Bcl-2蛋白表达减低(P<0.01),miR-30e-5p mRNA、P27^(kip1)、Cyt C、Bax、Caspase-3及Caspase-9蛋白表达升高(P<0.01或P<0.05)。结论该网络药理学和实验基本阐明,补阳还五汤可以通过miR-30e-5p调控MAP3K5,从而抑制增殖和促进凋亡,改善HPH大鼠肺血管重构,降低肺动脉压力。 展开更多
关键词 低氧性肺动脉高压 补阳还五汤 miR-30e-5p map3K5
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A magnetically compatible,arbitrary positioning system for accurate spatial mapping of magnetic fields for shimming studies in MRI
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作者 Yiqing Yin Wenchen Wang +6 位作者 Shihe Zhao Hui Wang Junsheng Cheng Shunzhong Chen Wenhui Yang Feng Liu Yaohui Wang 《Magnetic Resonance Letters》 2025年第3期50-55,共6页
After the fabrication of magnetic resonance superconducting magnets,the magnetic field inhomogeneity needs to be accurately measured for subsequent shimming.However,conventional measurement methods are susceptible to ... After the fabrication of magnetic resonance superconducting magnets,the magnetic field inhomogeneity needs to be accurately measured for subsequent shimming.However,conventional measurement methods are susceptible to magnetic fields,have poor compatibility,and are difficult to adapt to various types of magnets.This paper proposes a new field measuring system based on a three-axis movable platform.The system utilizes non-magnetic materials and an innovative hand-wheel lifting design that can be adapted to various aperture magnets,thus obviating the necessity for electrically driven equipment and addressing safety concerns in strong magnetic fields.In addition,the measurement system offers high accuracy up to 1 mm and a wide measurable range.The fields of 3 T and 7 T magnets were mapped using the designed system with diameter of spherical volume(DSV)of 160 mm and 130 mm,respectively.Experimental results demonstrate that the magnetic field measurement system has strong compatibility and can accurately map the magnetic field at arbitrary positions,which is critical for shimming studies. 展开更多
关键词 Magnetic field homogeneity Magnetic field mapping MRI
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Multi-dimensional hydrogen bonds regulated emissions of single-molecule system enabling surficial hydrophobicity/hydrophilicity mapping
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作者 Hao Gu Rui Li +6 位作者 Qiuying Li Sheng Lu Yahui Chen Xiaoning Yang Huili Ma Zhijun Xu Xiaoqiang Chen 《Chinese Chemical Letters》 2025年第5期515-520,共6页
Constructing multi-dimensional hydrogen bond(H-bond)regulated single-molecule systems with multiemission remains a challenge.Herein,we report the design of a new excited-state intramolecular proton transfer(ESIPT)feat... Constructing multi-dimensional hydrogen bond(H-bond)regulated single-molecule systems with multiemission remains a challenge.Herein,we report the design of a new excited-state intramolecular proton transfer(ESIPT)featured chromophore(HBT-DPI)that shows flexible emission tunability via the multidimensional regulation of intra-and intermolecular H-bonds.The feature of switchable intramolecular Hbonds is induced via incorporating several hydrogen bond acceptors and donors into one single HBT-DPI molecule,allowing the“turn on/off”of ESIPT process by forming isomers with distinct intramolecular Hbonds configurations.In response to different external H-bonding environments,the obtained four types of crystal/cocrystals vary in the contents of isomers and the molecular packing modes,which are mainly guided by the intermolecular H-bonds,exhibiting non-emissive features or emissions ranging from green to orange.Utilizing the feature of intermolecular H-bond guided molecular packing,we demonstrate the utility of this fluorescent material for visualizing hydrophobic/hydrophilic areas on large-scale heterogeneous surfaces of modified poly(1,1-difluoroethylene)(PVDF)membranes and quantitatively estimating the surface hydrophobicity,providing a new approach for hydrophobicity/hydrophilicity monitoring and measurement.Overall,this study represents a new design strategy for constructing multi-dimensional hydrogen bond regulated ESIPT-based fluorescent materials that enable multiple emissions and unique applications. 展开更多
关键词 Multi-dimensional hydrogen bonds Emission regulation Hydrophobicity/hydrophilicity Surficial mapping Excited-state intramolecular proton transfer
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The International System and the Peace Map for Africa’s Great Lakes Region (AGLR)
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作者 Sylvester Ndzelen Berinyuy 《International Relations and Diplomacy》 2025年第4期196-201,共6页
The African continent habituated with volatile conflicts and protracted violence,be it intra-state or inter-state is also acquainted with multi-ethnic tensions breeding different militias.The trend,although not new,is... The African continent habituated with volatile conflicts and protracted violence,be it intra-state or inter-state is also acquainted with multi-ethnic tensions breeding different militias.The trend,although not new,is the expanding phenomenon of Jihadism and general terrorism.Some of these and other forms of conflicts summarize the geopolitics of Africa’s Great Lakes Region(AGLR).The bloodbath wherein the subregion engrosses itself is not solely guided by political considerations.Both endogenous and exogenous capitalist economic profit have stirred the system while ethnic politics and politics on ethnic leanings have amplified the scenario.The endeavors of both the international community and regional blocs appear deficient-a consequence of the frailty of the UN system and general multilateralism.Peace is possible for AGLR when humanity is placed over the tidal wave of capitalist profit,patriotism over toxic ethnicity and respect is accorded to international jurisprudence emblemed by the bona fide principle of pacta sunt Servanda,without neglecting the capacity of the youth and peace education. 展开更多
关键词 The International system Africa’s Great Lakes Region Peace map toxic ethnicity Pacta sunt Servanda bona fide illicit economies capitalist profit peace education
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High‑density genetic mapping enhances genomic selection accuracy for complex traits in Populus
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作者 Chenchen Guo Tongming Yin Suyun Wei 《Journal of Forestry Research》 2026年第2期290-304,共15页
Populus species,important economic species combining rapid growth with broad ecological adaptability,play a critical role in sustainable forestry and bioenergy production.In this study,we performed whole-genome resequ... Populus species,important economic species combining rapid growth with broad ecological adaptability,play a critical role in sustainable forestry and bioenergy production.In this study,we performed whole-genome resequencing of 707 individuals from a full-sib family to develop comprehensive single nucleotide polymorphism(SNP)markers and constructed a high-density genetic linkage map of 19 linkage groups.The total genetic length of the map reached 3623.65 cM with an average marker interval of 0.34 cM.By integrating multidimensional phenotypic data,89 quantitative trait loci(QTL)associated with growth,wood physical and chemical properties,disease resistance,and leaf morphology traits were identified,with logarithm of odds(LOD)scores ranging from 3.13 to 21.72 Notably,pleiotropic analysis revealed significant colocaliza and phenotypic variance explained between 1.7% and 11.6%.-tion hotspots on chromosomes LG1,LG5,LG6,LG8,and LG14,with epistatic interaction network analysis confirming genetic basis of coordinated regulation across multiple traits.Functional annotation of 207 candidate genes showed that R2R3-MYB and bHLH transcription factors and pyruvate kinase-encoding genes were significantly enriched,suggesting crucial roles in lignin biosynthesis and carbon metabolic pathways.Allelic effect analysis indicated that the frequency of favorable alleles associated with target traits ranged from 0.20 to 0.55.Incorporation of QTL-derived favorable alleles as random effects into Bayesian-based genomic selection models led to an increase in prediction accuracy ranging from 1% to 21%,with Bayesian ridge regression as the best predictive model.This study provides valuable genomic resources and genetic insights for deciphering complex trait architecture and advancing molecular breeding in poplar. 展开更多
关键词 Genomic selection Genetic map Quantitative trait loci GROWTH Disease resistance
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Comparative Study on the Diagnostic Efficacy of Conventional MRI Sequences and T2 Mapping Sequences in Cartilage Injury
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作者 Wang Peng Zhi Liu +1 位作者 Juan Long Chanying Wang 《Journal of Clinical and Nursing Research》 2026年第1期284-291,共8页
Objective:To retrospectively evaluate the diagnostic efficacy of traditional MRI and T2 Mapping quantitative imaging technology for knee joint cartilage injury,clarify the differences in diagnostic value of the two im... Objective:To retrospectively evaluate the diagnostic efficacy of traditional MRI and T2 Mapping quantitative imaging technology for knee joint cartilage injury,clarify the differences in diagnostic value of the two imaging methods in different injury grades and different cartilage subregions,and provide evidence-based basis for the accurate diagnosis of clinical cartilage injury.Methods:Clinical and imaging data of 286 patients with knee joint lesions admitted to the Affiliated Hospital of Xiangtan Medicine and Health Vocational College from January 2020 to June 2023 were collected retrospectively.All patients underwent both traditional MRI sequences and T2 Mapping sequences.The knee joint cartilage was divided into 14 subregions.Two senior radiologists independently diagnosed the images of the two imaging technologies using a blind method and recorded the cartilage injury grades.The sensitivity,specificity,accuracy,positive predictive value,negative predictive value,and area under the receiver operating characteristic curve(AUC)of the two technologies for diagnosing cartilage injury were calculated and compared,and the differences in their diagnostic efficacy in different injury grades and different subregions were analyzed.Results:A total of 4004 cartilage subregions from 286 patients were included in the analysis,including 1836 injured subregions and 2168 normal subregions.The overall sensitivity(89.7%),accuracy(91.2%),and AUC(0.946)of T2 Mapping quantitative imaging for diagnosing cartilage injury were significantly higher than those of traditional MRI(76.3%,82.5%,and 0.852 respectively),with statistically significant differences(p<0.001);there was no significant difference in specificity between the two(93.5%vs 90.8%,p=0.062).Subgroup analysis showed that T2 Mapping had the most significant diagnostic advantage in early cartilage injury(Grade 1),with sensitivity(78.5%)33.2%higher than that of traditional MRI(45.3%)(p<0.001).Conclusion:The diagnostic efficacy of T2 Mapping quantitative imaging for knee joint cartilage injury is significantly superior to that of traditional MRI,especially in the detection of early cartilage injury and accurate evaluation of weight-bearing area injury.Data verify its clinical applicability and reliability.It can be used as an important supplementary method to traditional MRI,and is recommended for the early diagnosis,grading evaluation,and clinical follow-up of cartilage injury. 展开更多
关键词 Traditional MRI T2 mapping Cartilage injury Diagnostic efficacy Retrospective analysis
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RNPC-net:Automatic recognition and mapping of weathering degree and groundwater condition of tunnel faces
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作者 Xiang Wu Fengyan Wang +4 位作者 Jianping Chen Mingchang Wang Lina Cheng Chengyao Zhang Junke Xu 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第2期1138-1159,共22页
Accurate and rapid recognition of weathering degree(WD)and groundwater condition(GC)is essential for evaluating rock mass quality and conducting stability analyses in underground engineering.Conventional WD and GC rec... Accurate and rapid recognition of weathering degree(WD)and groundwater condition(GC)is essential for evaluating rock mass quality and conducting stability analyses in underground engineering.Conventional WD and GC recognition methods often rely on subjective evaluation by field experts,supplemented by field sampling and laboratory testing.These methods are frequently complex and timeconsuming,making it challenging to meet the rapidly evolving demands of underground engineering.Therefore,this study proposes a rock non-geometric parameter classification network(RNPC-net)to rapidly achieve the recognition and mapping ofWD and GC of tunnel faces.The hybrid feature extraction module(HFEM)in RNPC-net can fully extract,fuse,and utilize multi-scale features of images,enhancing the network's classification performance.Moreover,the designed adaptive weighting auxiliary classifier(AC)helps the network learn features more efficiently.Experimental results show that RNPC-net achieved classification accuracies of 0.8756 and 0.8710 for WD and GC,respectively,representing an improvement of approximately 2%e10%compared to other methods.Both quantitative and qualitative experiments confirm the effectiveness and superiority of RNPC-net.Furthermore,for WD and GC mapping,RNPC-net outperformed other methods by achieving the highest mean intersection over union(mIOU)across most tunnel faces.The mapping results closely align with measurements provided by field experts.The application of WD and GC mapping results to the rock mass rating(RMR)system achieved a transition from conventional qualitative to quantitative evaluation.This advancement enables more accurate and reliable rock mass quality evaluations,particularly under critical conditions of RMR. 展开更多
关键词 Tunnel face Weathering degree Groundwater condition RNPC-net Hybrid feature extraction module Recognition and mapping
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T2 mapping成像在踝关节骨性关节炎软骨退变评估中的应用价值
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作者 柴文武 《影像研究与医学应用》 2026年第4期106-108,共3页
目的:探讨T2 mapping成像在踝关节骨性关节炎(OA)软骨退变评估中的应用价值。方法:选取2025年1月—2025年9月徐州仁慈医院收治的60例踝关节OA患者(OA组)和50例健康体检志愿者(对照组)为研究对象,均行T2 mapping成像检查,比较两组负重区... 目的:探讨T2 mapping成像在踝关节骨性关节炎(OA)软骨退变评估中的应用价值。方法:选取2025年1月—2025年9月徐州仁慈医院收治的60例踝关节OA患者(OA组)和50例健康体检志愿者(对照组)为研究对象,均行T2 mapping成像检查,比较两组负重区、非负重区软骨T2值,并以关节镜结果为依据,参照软骨修复协会的分级标准将踝关节OA患者分为轻度损伤组(n=20)、中度损伤组(n=28)和重度损伤组(n=12),比较不同损伤分级踝关节OA患者软骨T2值差异。结果:OA组内、外踝骨的负重区与非负重区,以及距骨内侧前部、中部与后部的T2值均高于对照组(P<0.05);两组距骨外侧前部、中部、后部T2值比较,差异均无统计学意义(P>0.05)。重度损伤组距骨内侧前部、中部、后部T2值均高于中度损伤组、轻度损伤组,且中度损伤组距骨内侧前部、中部、后部T2值均高于轻度损伤组(P<0.05);不同损伤分级踝关节OA患者距骨外侧前部、中部、后部T2值比较,差异无统计学意义(P>0.05)。结论:T2 mapping成像能够量化评估踝关节软骨内部组织成分的变化,对早期踝关节OA的病情评估有一定的指导意义。 展开更多
关键词 踝关节 骨性关节炎 MRI T2 mapping 软骨损伤分级
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