Objective To investigate the changes of metabolites in urine of automobile manufacturing workers with muscle fatigue using metabolomics technology,and to explore potential biomarkers and disrupted metabolic pathways.M...Objective To investigate the changes of metabolites in urine of automobile manufacturing workers with muscle fatigue using metabolomics technology,and to explore potential biomarkers and disrupted metabolic pathways.Methods In July 2022,urine samples were collected from35maleworkers in a certain automobile manufacturing industry before and after muscle fatigue,and metabolite analysis was conducted.Subsequently,multivariate statistical analysis was uused fordata processing to screen differential metabolites.Metabolic pathway enrichment was performed using the Kyoto Encyclopedia of Genes and Genomes(KEGG)database(http://www.kegg.jp),and potential biomarkers were screened through the receiver operating characteristic(ROC)curve.Results Metabolomics analysis revealed that compared to pre-fatigue samples,a total of 363 differential metabolites were identified in the post-fatigue urine samples of the subjects.Among these,201 metabolites(55.4%)showed increased relative expression,while 162 metabolites(44.6%)showed decreased relative expression.The metabolic pathways involved mainly included histidine metabolism,tryptophan metabolism,valine,leucine and isoleucine biosynthesis,caffeine metabolism,niacin and nicotinamide metabolism,and oxidative phosphorylation.The ROC curve analysis results showed that the areas under the ROC curves for 1-methylnicotinamide,2-piperidinone,kojic acid and diferuloyl Putrescine were 0.992,0.959,0.937 and 0.902,respectively.Conclusion Muscle fatigue could cause changes in urine metabolite profiles of automobile manufacturing workers.The metabolites represented by 1-methylnicotinamide in urine can be used as potential biomarkers。展开更多
Background:Women working in manufacturing are exposed to harmful chemicals and gases;environmental and psychosocial factors such as stress,anxiety,and burnout severely affect their reproductive health.Like physiologic...Background:Women working in manufacturing are exposed to harmful chemicals and gases;environmental and psychosocial factors such as stress,anxiety,and burnout severely affect their reproductive health.Like physiological factors,psychosocial factors equality disrupts women’s reproductive health who are working in such aversive circumstances.Method:The current study is a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis checklist.The primary sources of articles were central databases such as SCOPUS,Web of Science,PubMed,and others.Cambridge Quality Checklist was used to measure the quality of the review articles.Result:A total of 14 articles were found eligible for the review;5 studies were on occupational health in general,3 studies addressed menstrual distress,3 studies on pregnancy,and 3 on menopausal issues.Pandemic experiences increase the health risk with the rise in food and financial insecurity among manufacturing workers.Conclusion:Psychosocial factors such as stress,anxiety,loneliness,discrimination,and depression are associated with a risk to reproductive health.The uncertainty caused by the pandemic was a major stressor for the manufacturing workers in India.The findings would represent significant challenges and factors affecting women’s reproductive health.Proper interventions and measures could be taken to regulate health risks.展开更多
文摘Objective To investigate the changes of metabolites in urine of automobile manufacturing workers with muscle fatigue using metabolomics technology,and to explore potential biomarkers and disrupted metabolic pathways.Methods In July 2022,urine samples were collected from35maleworkers in a certain automobile manufacturing industry before and after muscle fatigue,and metabolite analysis was conducted.Subsequently,multivariate statistical analysis was uused fordata processing to screen differential metabolites.Metabolic pathway enrichment was performed using the Kyoto Encyclopedia of Genes and Genomes(KEGG)database(http://www.kegg.jp),and potential biomarkers were screened through the receiver operating characteristic(ROC)curve.Results Metabolomics analysis revealed that compared to pre-fatigue samples,a total of 363 differential metabolites were identified in the post-fatigue urine samples of the subjects.Among these,201 metabolites(55.4%)showed increased relative expression,while 162 metabolites(44.6%)showed decreased relative expression.The metabolic pathways involved mainly included histidine metabolism,tryptophan metabolism,valine,leucine and isoleucine biosynthesis,caffeine metabolism,niacin and nicotinamide metabolism,and oxidative phosphorylation.The ROC curve analysis results showed that the areas under the ROC curves for 1-methylnicotinamide,2-piperidinone,kojic acid and diferuloyl Putrescine were 0.992,0.959,0.937 and 0.902,respectively.Conclusion Muscle fatigue could cause changes in urine metabolite profiles of automobile manufacturing workers.The metabolites represented by 1-methylnicotinamide in urine can be used as potential biomarkers。
文摘Background:Women working in manufacturing are exposed to harmful chemicals and gases;environmental and psychosocial factors such as stress,anxiety,and burnout severely affect their reproductive health.Like physiological factors,psychosocial factors equality disrupts women’s reproductive health who are working in such aversive circumstances.Method:The current study is a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis checklist.The primary sources of articles were central databases such as SCOPUS,Web of Science,PubMed,and others.Cambridge Quality Checklist was used to measure the quality of the review articles.Result:A total of 14 articles were found eligible for the review;5 studies were on occupational health in general,3 studies addressed menstrual distress,3 studies on pregnancy,and 3 on menopausal issues.Pandemic experiences increase the health risk with the rise in food and financial insecurity among manufacturing workers.Conclusion:Psychosocial factors such as stress,anxiety,loneliness,discrimination,and depression are associated with a risk to reproductive health.The uncertainty caused by the pandemic was a major stressor for the manufacturing workers in India.The findings would represent significant challenges and factors affecting women’s reproductive health.Proper interventions and measures could be taken to regulate health risks.
