Purpose–The study aims to build a high-precision longitudinal dynamics model for heavy-haul trains and validate it with line test data,present an optimization method for multi-stage cyclic brakes based on the model a...Purpose–The study aims to build a high-precision longitudinal dynamics model for heavy-haul trains and validate it with line test data,present an optimization method for multi-stage cyclic brakes based on the model and conduct a multi-objective detailed evaluation of the driver’s manipulation during cyclic braking.Design/methodology/approach–The high-precision longitudinal train dynamics model was established and verified by the cyclic braking test data of the 20,000 t heavy-haul combination train on the long and steep downgrade.Then the genetic algorithm is employed for optimization subsequent to decoupling multiple cyclic braking procedures,with due consideration of driver operation rules.For evaluation,key manipulation assessments in the scenario are prioritized,supplemented by multi-objective evaluation requirements,and the computational model is employed for detailed evaluation analysis.Findings–Based on the model,experimental data reveal that the probability of longitudinal force error being less than 64.6 kN is approximately 68%,95%for less than 129.2 kN and 99.7%for less than 193.8 kN.Upon optimizing manipulations during the cyclic braking,the maximum reduction in coupler force spans from 21%∼23.9%.Andtheevaluation scoresimply that a proper elevationof the releasingspeed favorssafety.A high electric braking force,although beneficial to some extent for energy-saving,is detrimental to reducing coupler force.Originality/value–The results will provide a theoretical basis and practical guidance for further ensuring the safety and energy-efficient operation of heavy haul trains on long downhill sections and improving the operational quality of heavy-haul trains.展开更多
Animals exhibit complex responses to external and internal stimuli.The information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane potential.How can neuron...Animals exhibit complex responses to external and internal stimuli.The information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane potential.How can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.展开更多
OBJECTIVE:In recent years,the number of clinical research reports on acupuncture and manipulation for the treatment of greater occipital neuralgia has gradually increased,but the quality is uneven.There is currently n...OBJECTIVE:In recent years,the number of clinical research reports on acupuncture and manipulation for the treatment of greater occipital neuralgia has gradually increased,but the quality is uneven.There is currently no literature evaluating the quality of published reports,which is not conducive to the promotion of clinical use of these therapies.Therefore,this article assessed the reporting quality of randomized controlled trials on acupuncture and manipulation for greater occipital neuralgia.METHODS:Cochrane Library,PubMed,Web of Science,Embase,China National Knowledge Infrastructure(CNKI),VIP,WanFang Data,and Chinese BioMedical Literature Database(CBM)from inception to May 20,2024 were searched.The reporting quality of included randomized controlled trials was independently evaluated by two investigators using the CONSORT statement,STRICTA checklist,and Cochrane bias of risk assessment tool.A third investigator resolved any disagreement.RESULTS:A total of 62 articles were included.Based on the CONSORT statement,59.46%(22/37)of all entries had a reporting rate of less than 50%,mainly including“Identification as a randomized trial in the title(1/62,1.61%),”“How sample size was determined(7/62,11.29%),”“Implementation(1/62,1.61%),”“Blinding(1/62,1.61%),”and“Reports of Funding(4/62,6.45%).”According to the STRICTA checklist,29.41%(5/17)of all entries had a reporting rate of less than 50%,mainly including“Details of other interventions(7/58,12.07%),”“Setting and context of treatment(0/58,0%),”and“Description of participating acupuncturists(0/58,0%).”CONCLUSION:The reporting quality of randomized controlled trials on acupuncture and manipulation therapy for greater occipital neuralgia remains low.Future researchers need to make greater efforts to strictly adhere to the CONSORT statement and STRICTA checklist during trial design,implementation,and reporting.This will facilitate the standardization of research in this field and enhance the reliability and reproducibility of the research results.展开更多
Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of curr...Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of current optical modulation technologies in achieving full-parameter precision control,we proposed a novel approach for dynamic azimuthal optical field modulation based on dual-spiral arrays.By designing spatially interleaved spiral structures with different initial radii while maintaining identical periodic parameters,we achieved continuous optical modulation spanning the full 0-2πrange in azimuthal field distribution.Through rigorous numerical simulations,we systematically established a quantitative correlation between the structural parameters and azimuthal optical field patterns,revealing,for the first time,a quasi-linear relationship between the radius difference and the resultant optical distribution.This theoretical framework advances our fundamental understanding of structured optical field manipulation as well as provides a new paradigm for programmable photonic device design,with distinct technical advantages in super-resolution imaging and optical tweezer systems.展开更多
[Objectives]To investigate the effects of Visceral Manipulation combined with Enhanced Recovery after Surgery on postoperative recovery in patients undergoing gastrointestinal surgery,and to evaluate its impacts on in...[Objectives]To investigate the effects of Visceral Manipulation combined with Enhanced Recovery after Surgery on postoperative recovery in patients undergoing gastrointestinal surgery,and to evaluate its impacts on inflammatory stress response,gastrointestinal motility recovery,and blood oxygen levels.[Methods]A prospective randomized controlled design was adopted.Eighty patients undergoing gastrointestinal surgery from January 2022 to December 2023 were selected and randomly divided into an observation group(40 cases)and a control group(40 cases).The observation group received Visceral Manipulation therapy in addition to routine Enhanced Recovery after Surgery care,while the control group received only routine Enhanced Recovery after Surgery care.Clinical indicators,inflammatory factors(TNF-α,IL-6,hs-CRP),traumatic stress hormones(cortisol,epinephrine,norepinephrine),gastrointestinal motility indicators(GAS,MTL,GIP),and blood oxygen levels were measured and compared between the two groups on postoperative days 1,5,and 10.[Results]The observation group showed significantly better outcomes in postoperative abdominal distension,time to first flatus and defecation,and hospital stay compared to the control group(P<0.05).Inflammatory factors(TNF-α,IL-6,hs-CRP),traumatic stress hormones(cortisol,epinephrine,norepinephrine),and gastrointestinal motility indicators(GAS,MTL,GIP)were significantly improved in the observation group(P<0.05).Postoperative blood oxygen levels were also significantly higher in the observation group(P<0.05).[Conclusions]Visceral Manipulation combined with Enhanced Recovery after Surgery can significantly improve postoperative recovery in gastrointestinal surgery patients,alleviate inflammatory stress responses,promote gastrointestinal functional recovery,and enhance blood oxygen levels,demonstrating promising clinical application prospects.展开更多
The original intention of the algorithmic recommender system is to grapple with the negative impacts caused by information overload,but the system also can be used as"hypernudge",a new form of online manipul...The original intention of the algorithmic recommender system is to grapple with the negative impacts caused by information overload,but the system also can be used as"hypernudge",a new form of online manipulation,to inten⁃tionally exploit people's cognitive and decision-making gaps to influence their decisions in practice,which is particu⁃larly detrimental to the sustainable development of the digital market.Limiting harmful algorithmic online manipula⁃tion in digital markets has become a challenging task.Globally,both the EU and China have responded to this issue,and the differences between them are so evident that their governance measures can serve as the typical case.The EU focuses on improving citizens'digital literacy and their ability to integrate into digital social life to independently ad⁃dress this issue,and expects to address harmful manipulation behavior through binding and applicable hard law,which is part of the digital strategy.By comparison,although there exist certain legal norms that have made relevant stipula⁃tions on manipulation issues,China continues to issue specific departmental regulations to regulate algorithmic recom⁃mender services,and pays more attention to addressing collective harm caused by algorithmic online manipulation through a multiple co-governance approach led by the government or industry associations to implement supervision.展开更多
Nanomaterials provide an ideal platform for biomolecular display due to their dimensions approach the molecular scale,facilitating binding behavior akin to that observed in solution-based processes.DNA nanoprobes hold...Nanomaterials provide an ideal platform for biomolecular display due to their dimensions approach the molecular scale,facilitating binding behavior akin to that observed in solution-based processes.DNA nanoprobes hold great promise as miniature detectives capable of detecting mi RNAs within cells.However,current nanoprobes face a challenge in achieving the required precision for accurate miRNA detection,particularly within the intricate confines of the cellular microenvironment,due to interference with biological autofluorescence,off-target effects,and a lack of spatiotemporal control.Here,we have designed a dual-stimuli responsive DNA tracker,synergistically utilizing specific intracellular cues and external triggers,which enables spatiotemporal-controlled and precise detection and imaging of miRNAs"on demand".The tracker,which combines zeolitic imidazolate framework-67(ZIF-67)and unique hairpin DNA structures,effectively anchored onto the ZIF-67 through electrostatic interactions,remains in a dormant state until activated by abundant cellular ATP,resulting in the release of the hairpin structures that include a PC linker incorporated into the loop region.Subsequent irradiation triggers specific recognition of the target miRNA.The newly developed HP-PC-BT@ZIF-67 tracker demonstrates precise spatiotemporal mi RNA detection and exhibits excellent biocompatibility,enabling specific mi RNA recognition"on demand"within cancer cells.This research presents a reliable mi RNA imaging platform in the intricate cellular environment,opening up the possibilities for precise biomedical analysis and disease diagnosis.展开更多
On-demand droplet manipulation plays a critical role in microfluidics,bio/chemical detection and microreactions.Acoustic droplet manipulation has emerged as a promising technique due to its non-contact nature,biocompa...On-demand droplet manipulation plays a critical role in microfluidics,bio/chemical detection and microreactions.Acoustic droplet manipulation has emerged as a promising technique due to its non-contact nature,biocompatibility and precision,circumventing the complexities associated with other methods requiring surface or droplet pretreatment.Despite their promise,existing methods for acoustic droplet manipulation often involve complex hardware setups and difficulty for controlling individual droplet amidst multiple ones.Here we fabricate simple yet effective acoustic tweezers for in-surface and out-of-surface droplet manipulation.It is found that droplets can be transported on the superhydrophobic surfaces when the acoustic radiation force surpasses the friction force.Using a two-axis acoustic tweezer,droplets can be maneuvered along arbitrarily programmed paths on the surfaces.By introducing multiple labyrinthine structures on the superhydrophobic surface,individual droplet manipulation is realized by constraining the unselected droplets in the labyrinthine structures.In addition,a three-axis acoustic tweezer is developed for manipulating droplets in three-dimensional space.Potential applications of the acoustic tweezers for micro-reaction,bio-assay and chemical analysis are also demonstrated.展开更多
Controllable liquid manipulation is of paramount scientific and technological importance in various fields,such as the chemical industry,biomedicine,and agricultural production.Magnetic actuation,characterized by rapi...Controllable liquid manipulation is of paramount scientific and technological importance in various fields,such as the chemical industry,biomedicine,and agricultural production.Magnetic actuation,characterized by rapid,contactless,and environmentally benign operation,has emerged as a promising approach for precise liquid control.However,conventional magnetic strategies typically govern droplet movement on open surfaces,facing limitations such as restricted liquid volumes,uncertain flow paths,and inevitable evaporation,thereby constraining their broader practical applications.Recently,a variety of magneticdriven strategies have been developed to dynamically regulate liquids within enclosed spaces,especially through physicochemical mechanisms.These approaches provide efficient control over liquid behavior by leveraging magnetically induced chemical changes,structural deformations,and dragging motions,opening new opportunities for flexible and versatile fluid management.This review explores the design and mechanisms of magneto-responsive confined interfaces for the manipulation of nonmagnetic liquids,highlighting key advancements and potential applications including liquid valves,liquid mixing,liquid flow regulation,and liquid pumping.Finally,the existing challenges and future prospects in this field are presented.展开更多
Purpose:This study aimed to evaluate the relationship between peak tibial acceleration and peak ankle joint contact forces in response to stride length manipulation during level-ground running.Methods:Twenty-seven phy...Purpose:This study aimed to evaluate the relationship between peak tibial acceleration and peak ankle joint contact forces in response to stride length manipulation during level-ground running.Methods:Twenty-seven physically active participants ran 10 trials at preferred speed in each of 5 stride length conditions:preferred,±5%,and±10%of preferred stride length.Motion capture,force platform,and tibial acceleration data were directly measured,and ankle joint contact forces were estimated using an inverse-dynamics-based static optimization routine.Results:In general,peak axial tibial accelerations(p<0.001)as well as axial(p<0.001)and resultant(p<0.001)ankle joint contact forces increased with stride length.When averaged within the 10 strides of each stride condition,moderate positive correlations were observed between peak axial acceleration and joint contact force(r=0.49)as well as peak resultant acceleration and joint contact force(r=0.51).However,37%of participants illustrated either no relationship or negative correlations.Only weak correlations across participants existed between peak axial acceleration and joint contact force(r=0.12)as well as peak resultant acceleration and ankle joint contact force(r=0.18)when examined on a step-by-step basis.Conclusion:These results suggest that tibial acceleration should not be used as a surrogate for ankle joint contact force on a step-by-step basis in response to stride length manipulations during level-ground running.A 10-step averaged tibial acceleration metric may be useful for some runners,but an initial laboratory assessment would be required to identify these individuals.展开更多
In existing image manipulation localization methods,the receptive field of standard convolution is limited,and during feature transfer,it is easy to lose high-frequency information about traces of manipulation.In addi...In existing image manipulation localization methods,the receptive field of standard convolution is limited,and during feature transfer,it is easy to lose high-frequency information about traces of manipulation.In addition,during feature fusion,the use of fixed sampling kernels makes it difficult to focus on local changes in features,leading to limited localization accuracy.This paper proposes an image manipulation localization method based on dual-branch hybrid convolution.First,a dual-branch hybrid convolution module is designed to expand the receptive field of the model to enhance the feature extraction ability of contextual semantic information,while also enabling the model to focus more on the high-frequency detail features of manipulation traces while localizing the manipulated area.Second,a multiscale content-aware feature fusion module is used to dynamically generate adaptive sampling kernels for each position in the feature map,enabling the model to focus more on the details of local features while locating the manipulated area.Experimental results on multiple datasets show that this method not only effectively improves the accuracy of image manipulation localization but also enhances the robustness of the model.展开更多
In the fields of optoelectronics and semiconductors, reliable fixation and handling of brittle materials (glass, wafer, etc.) in high-temperature, vacuum, and vibration environments face particular technical challenge...In the fields of optoelectronics and semiconductors, reliable fixation and handling of brittle materials (glass, wafer, etc.) in high-temperature, vacuum, and vibration environments face particular technical challenges. These challenges include the inability of suction cups in a vacuum, the residue of chemical adhesives, and the easy damage of mechanical clamping. In this paper, fluorine-based bionic adhesive pads (FBAPs) obtained using molding technology to imitate gecko micropillar arrays are presented. FBAPs inhibit the substantial decay of adhesive properties at high temperatures and provide stable and reliable performance in vacuum and vibration environments. The results demonstrated that the decayed force values of the normal and tangential strength of the FBAP were only 9.01% and 5.82% of the planar samples when warmed up to 300℃ from 25℃, respectively. In a vacuum, all FBAPs exhibit less than 20% adhesion attenuation, and in a vibrational environment, they can withstand accelerations of at least 4.27 g. The design of the microstructure arrays enables the realization of efficient and non-destructive separation through mechanical rotation or blowing. It provides a bionic material basis for the fixation of brittle materials on smooth surfaces under complex environments and for transportation automation.展开更多
Existing image manipulation localization(IML)techniques require large,densely annotated sets of forged images.This requirement greatly increases labeling costs and limits a model’s ability to handle manipulation type...Existing image manipulation localization(IML)techniques require large,densely annotated sets of forged images.This requirement greatly increases labeling costs and limits a model’s ability to handle manipulation types that are novel or absent from the training data.To address these issues,we present CLIP-IML,an IML framework that leverages contrastive language-image pre-training(CLIP).A lightweight feature-reconstruction module transforms CLIP token sequences into spatial tensors,after which a compact feature-pyramid network and a multi-scale fusion decoder work together to capture information from fine to coarse levels.We evaluated CLIP-IML on ten public datasets that cover copy-move,splicing,removal,and artificial intelligence(AI)-generated forgeries.The framework raises the average F1-score by 7.85%relative to the strongest recent baselines and secures either the first-or second-place performance on every dataset.Ablation studies show that CLIP pre-training,higher resolution inputs,and the multi-scale decoder each make complementary contributions.Under six common post-processing perturbations,as well as the compression pipelines used by Facebook,Weibo,and WeChat,the performance decline never exceeds 2.2%,confirming strong practical robustness.Moreover,CLIP-IML requires only a few thousand annotated images for training,which markedly reduces data-collection and labeling effort compared with previous methods.All of these results indicate that CLIP-IML is highly generalizable for image tampering localization across a wide range of tampering scenarios.展开更多
[Objectives]To investigate the therapeutic effects of combined treatment on children diagnosed with pseudomyopia,based on the theoretical framework that the liver is associated with eye health in traditional Chinese m...[Objectives]To investigate the therapeutic effects of combined treatment on children diagnosed with pseudomyopia,based on the theoretical framework that the liver is associated with eye health in traditional Chinese medicine.[Methods]A multicenter randomized controlled trial was conducted involving 100 children,with the treatment group consisting of 50 participants receiving a combined treatment,while the control group,also comprising 50 participants,received conventional tuina.In the treatment group,the Yizhichan Pushing Manipulation was applied at a frequency of 120 times/min and a strength of 0.5-1.0 kg,targeting acupoints such as Ganyu and Guangming.The alterations in naked eye visual acuity,diopter measurements,and ciliary muscle regulation function were compared between the two groups of children both prior to and following treatment,and the clinical efficacy was assessed.[Results]The treatment group demonstrated a statistically significant enhancement in visual acuity(1.74±0.49 lines vs.1.02±0.52 lines),diopter improvement(0.91±0.29 D vs.0.46±0.25 D),and overall efficiency(96%vs.78%)when compared to the control group(all P<0.01).[Conclusions]This combined treatment exerts a therapeutic effect through a dual mechanism that involves the regulation of liver meridian qi and blood,as well as the enhancement of ciliary muscle function.This approach merits further dissemination and application in the prevention and management of myopia in children.展开更多
The complexity and intricacy of the brain,which is composed of billions of neurons,pose significant challenges to its study.Understanding neural connections and communication at the single-cell level is crucial for un...The complexity and intricacy of the brain,which is composed of billions of neurons,pose significant challenges to its study.Understanding neural connections and communication at the single-cell level is crucial for unraveling the brain’s functions.This study presents a novel strategy that utilizes magnetic nanoparticles(MNPs)and magnetic fields to manipulate neurons,thereby creating customized small-scale neural circuits for studying neural connections.To establish the feasibility of this approach,the effects of MNPs on neurons were initially investigated,demonstrating their low toxicity.Subsequently,a micromagnet array(MMA)chip was employed to manipulate the neurons,facilitating their precise arrangement on the electrodes.Over several days,the neurons extended their axons and established connections with neighboring cells,forming small-scale circular neural circuits.These artificially engineered circuits offer a simplified and controlled environment for studying neural networks in contrast to naturally occurring biological networks.Furthermore,electrophysiological recordings were conducted to investigate the connections between the manipulated neurons.This study introduces a customized small-scale neural circuit platform with electrode-specific recording and stimulating capabilities,enabling the study of neuron-to-neuron interactions at the single-cell level.By leveraging MNPs and an MMA chip,this research offers a powerful tool for studying neural connections and advancing our understanding of the brain’s intricate workings.展开更多
The design and manufacturing of microchannels are crucial aspects of modern micro/nanomanufacturing processes,offering a versatile platform for manipulating and driving micro/nanoparticles or cells.In this study,we pr...The design and manufacturing of microchannels are crucial aspects of modern micro/nanomanufacturing processes,offering a versatile platform for manipulating and driving micro/nanoparticles or cells.In this study,we propose a method for manufacturing microchannels using optically induced dielectrophoresis technology to induce the polymerization of polyethylene glycol diacrylate solution.To overcome limitations related to the light intensity energy and the size of intact microchannels,we design and manufacture microstructures of various shapes with a height of 4µm.Additionally,we simulate and analyze the movement of and forces acting on polystyrene(PS)microspheres at different spatial positions within the microchannels.Finally,we successfully demonstrate applications involving the transport of PS microspheres in custom-fabricated microchannels.This novel biocompatible microchannel manufacturing method is simple and non-biotoxic.It provides a new approach for simulating physiological environments in vitro and cultivating and manipulating cells.展开更多
Coupled-waveguide devices are essential in photonic integrated circuits for coupling,polarization handling,and mode manipulation.However,the performance of these devices usually suffers from high wavelength and struct...Coupled-waveguide devices are essential in photonic integrated circuits for coupling,polarization handling,and mode manipulation.However,the performance of these devices usually suffers from high wavelength and structure sensitivity,which makes it challenging to realize broadband and reliable on-chip optical functions.Recently,topological pumping of edge states has emerged as a promising solution for implementing robust optical couplings.In this paper,we propose and experimentally demonstrate broadband on-chip mode manipulation with very large fabrication tolerance based on the Rice–Mele modeled silicon waveguide arrays.The Thouless pumping mechanism is employed in the design to implement broadband and robust mode conversion and multiplexing.The experimental results prove that various mode-order conversions with low insertion losses and intermodal crosstalk can be achieved over a broad bandwidth of 80 nm ranging from 1500 to 1580 nm.Thanks to such a topological design,the device has a remarkable fabrication tolerance of±70 nm for the structural deviations in waveguide width and gap distance,which is,to the best of our knowledge,the highest among the coupled-waveguide mode-handling devices reported so far.As a proof-of-concept experiment,we cascade the topological mode-order converters to form a four-channel mode-division multiplexer and demonstrate the transmission of a 200-Gb/s 16-quadrature amplitude modulation signal for each mode channel,with the bit error rates below the 7%forward error correction threshold of 3.8×10^(-3).We reveal the possibility of developing new classes of broadband and fabrication-tolerant coupled-waveguide devices with topological photonic approaches,which may find applications in many fields,including optical interconnects,quantum communications,and optical computing.展开更多
Manipulating and braiding Majorana zero modes(MZM)are a critical step toward realizing topological quantum computing.The primary challenge is controlling the vortex,which hosts the MZM,within a superconducting film in...Manipulating and braiding Majorana zero modes(MZM)are a critical step toward realizing topological quantum computing.The primary challenge is controlling the vortex,which hosts the MZM,within a superconducting film in a spatially precise manner.To address this,we developed a magnetic force-based vortex control technology using the STM system with a self-designed four-electrode piezo-scanner tube and investigated vortex manipulation on the NbSe_(2) superconducting film.We employed ferromagnetic tips to control the movement of vortex array induced by the tip's remanent magnetism.A magnetic core solenoid device was integrated into the STM system and a strong magnetic tip demagnetization technique was developed,providing a viable technical solution for further enabling single vortex manipulation.展开更多
Transient negative capacitance(NC),as an available dynamic charge effect achieved in resistor-ferroelectric capacitor(R-FEC)circuits,has triggered a series of theoretical and experimental works focusing on its physica...Transient negative capacitance(NC),as an available dynamic charge effect achieved in resistor-ferroelectric capacitor(R-FEC)circuits,has triggered a series of theoretical and experimental works focusing on its physical mechanism and device application.Here,we analytically derived the effects of different mechanical conditions on the transient NC behaviors in the R-FEC circuit based on the phenomenological model.It shows that the ferroelectric capacitor can exhibit either NC(i.e.,“single NC”and“double NC”)or positive capacitance,depending on the mechanical condition and temperature.Further numerical calculations show that the voltage drop caused by NC can be effectively controlled by temperature,applied stress,or strain.The relationship between NC voltage drop and system configurations including external resistance,dynamical coefficient of polarization,and input voltage are presented,showing diverse strategies to manipulate the NC effect.These results provide theoretical guidelines for rational design and efficient control of NC-related electronic devices.展开更多
文摘Purpose–The study aims to build a high-precision longitudinal dynamics model for heavy-haul trains and validate it with line test data,present an optimization method for multi-stage cyclic brakes based on the model and conduct a multi-objective detailed evaluation of the driver’s manipulation during cyclic braking.Design/methodology/approach–The high-precision longitudinal train dynamics model was established and verified by the cyclic braking test data of the 20,000 t heavy-haul combination train on the long and steep downgrade.Then the genetic algorithm is employed for optimization subsequent to decoupling multiple cyclic braking procedures,with due consideration of driver operation rules.For evaluation,key manipulation assessments in the scenario are prioritized,supplemented by multi-objective evaluation requirements,and the computational model is employed for detailed evaluation analysis.Findings–Based on the model,experimental data reveal that the probability of longitudinal force error being less than 64.6 kN is approximately 68%,95%for less than 129.2 kN and 99.7%for less than 193.8 kN.Upon optimizing manipulations during the cyclic braking,the maximum reduction in coupler force spans from 21%∼23.9%.Andtheevaluation scoresimply that a proper elevationof the releasingspeed favorssafety.A high electric braking force,although beneficial to some extent for energy-saving,is detrimental to reducing coupler force.Originality/value–The results will provide a theoretical basis and practical guidance for further ensuring the safety and energy-efficient operation of heavy haul trains on long downhill sections and improving the operational quality of heavy-haul trains.
文摘Animals exhibit complex responses to external and internal stimuli.The information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane potential.How can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.
文摘OBJECTIVE:In recent years,the number of clinical research reports on acupuncture and manipulation for the treatment of greater occipital neuralgia has gradually increased,but the quality is uneven.There is currently no literature evaluating the quality of published reports,which is not conducive to the promotion of clinical use of these therapies.Therefore,this article assessed the reporting quality of randomized controlled trials on acupuncture and manipulation for greater occipital neuralgia.METHODS:Cochrane Library,PubMed,Web of Science,Embase,China National Knowledge Infrastructure(CNKI),VIP,WanFang Data,and Chinese BioMedical Literature Database(CBM)from inception to May 20,2024 were searched.The reporting quality of included randomized controlled trials was independently evaluated by two investigators using the CONSORT statement,STRICTA checklist,and Cochrane bias of risk assessment tool.A third investigator resolved any disagreement.RESULTS:A total of 62 articles were included.Based on the CONSORT statement,59.46%(22/37)of all entries had a reporting rate of less than 50%,mainly including“Identification as a randomized trial in the title(1/62,1.61%),”“How sample size was determined(7/62,11.29%),”“Implementation(1/62,1.61%),”“Blinding(1/62,1.61%),”and“Reports of Funding(4/62,6.45%).”According to the STRICTA checklist,29.41%(5/17)of all entries had a reporting rate of less than 50%,mainly including“Details of other interventions(7/58,12.07%),”“Setting and context of treatment(0/58,0%),”and“Description of participating acupuncturists(0/58,0%).”CONCLUSION:The reporting quality of randomized controlled trials on acupuncture and manipulation therapy for greater occipital neuralgia remains low.Future researchers need to make greater efforts to strictly adhere to the CONSORT statement and STRICTA checklist during trial design,implementation,and reporting.This will facilitate the standardization of research in this field and enhance the reliability and reproducibility of the research results.
文摘Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of current optical modulation technologies in achieving full-parameter precision control,we proposed a novel approach for dynamic azimuthal optical field modulation based on dual-spiral arrays.By designing spatially interleaved spiral structures with different initial radii while maintaining identical periodic parameters,we achieved continuous optical modulation spanning the full 0-2πrange in azimuthal field distribution.Through rigorous numerical simulations,we systematically established a quantitative correlation between the structural parameters and azimuthal optical field patterns,revealing,for the first time,a quasi-linear relationship between the radius difference and the resultant optical distribution.This theoretical framework advances our fundamental understanding of structured optical field manipulation as well as provides a new paradigm for programmable photonic device design,with distinct technical advantages in super-resolution imaging and optical tweezer systems.
基金Supported by Guiding Project of Shiyan City,Hubei Province in 2022(22Y30).
文摘[Objectives]To investigate the effects of Visceral Manipulation combined with Enhanced Recovery after Surgery on postoperative recovery in patients undergoing gastrointestinal surgery,and to evaluate its impacts on inflammatory stress response,gastrointestinal motility recovery,and blood oxygen levels.[Methods]A prospective randomized controlled design was adopted.Eighty patients undergoing gastrointestinal surgery from January 2022 to December 2023 were selected and randomly divided into an observation group(40 cases)and a control group(40 cases).The observation group received Visceral Manipulation therapy in addition to routine Enhanced Recovery after Surgery care,while the control group received only routine Enhanced Recovery after Surgery care.Clinical indicators,inflammatory factors(TNF-α,IL-6,hs-CRP),traumatic stress hormones(cortisol,epinephrine,norepinephrine),gastrointestinal motility indicators(GAS,MTL,GIP),and blood oxygen levels were measured and compared between the two groups on postoperative days 1,5,and 10.[Results]The observation group showed significantly better outcomes in postoperative abdominal distension,time to first flatus and defecation,and hospital stay compared to the control group(P<0.05).Inflammatory factors(TNF-α,IL-6,hs-CRP),traumatic stress hormones(cortisol,epinephrine,norepinephrine),and gastrointestinal motility indicators(GAS,MTL,GIP)were significantly improved in the observation group(P<0.05).Postoperative blood oxygen levels were also significantly higher in the observation group(P<0.05).[Conclusions]Visceral Manipulation combined with Enhanced Recovery after Surgery can significantly improve postoperative recovery in gastrointestinal surgery patients,alleviate inflammatory stress responses,promote gastrointestinal functional recovery,and enhance blood oxygen levels,demonstrating promising clinical application prospects.
文摘The original intention of the algorithmic recommender system is to grapple with the negative impacts caused by information overload,but the system also can be used as"hypernudge",a new form of online manipulation,to inten⁃tionally exploit people's cognitive and decision-making gaps to influence their decisions in practice,which is particu⁃larly detrimental to the sustainable development of the digital market.Limiting harmful algorithmic online manipula⁃tion in digital markets has become a challenging task.Globally,both the EU and China have responded to this issue,and the differences between them are so evident that their governance measures can serve as the typical case.The EU focuses on improving citizens'digital literacy and their ability to integrate into digital social life to independently ad⁃dress this issue,and expects to address harmful manipulation behavior through binding and applicable hard law,which is part of the digital strategy.By comparison,although there exist certain legal norms that have made relevant stipula⁃tions on manipulation issues,China continues to issue specific departmental regulations to regulate algorithmic recom⁃mender services,and pays more attention to addressing collective harm caused by algorithmic online manipulation through a multiple co-governance approach led by the government or industry associations to implement supervision.
基金supported by the National Natural Science Foundation of China(Nos.21904095,22004089)Peiyang Talents Project of Tianjin University+1 种基金Young Thousand Talented ProgramProgram of Tianjin Science and Technology Major Project and Engineering(No.19ZXYXSY00090)。
文摘Nanomaterials provide an ideal platform for biomolecular display due to their dimensions approach the molecular scale,facilitating binding behavior akin to that observed in solution-based processes.DNA nanoprobes hold great promise as miniature detectives capable of detecting mi RNAs within cells.However,current nanoprobes face a challenge in achieving the required precision for accurate miRNA detection,particularly within the intricate confines of the cellular microenvironment,due to interference with biological autofluorescence,off-target effects,and a lack of spatiotemporal control.Here,we have designed a dual-stimuli responsive DNA tracker,synergistically utilizing specific intracellular cues and external triggers,which enables spatiotemporal-controlled and precise detection and imaging of miRNAs"on demand".The tracker,which combines zeolitic imidazolate framework-67(ZIF-67)and unique hairpin DNA structures,effectively anchored onto the ZIF-67 through electrostatic interactions,remains in a dormant state until activated by abundant cellular ATP,resulting in the release of the hairpin structures that include a PC linker incorporated into the loop region.Subsequent irradiation triggers specific recognition of the target miRNA.The newly developed HP-PC-BT@ZIF-67 tracker demonstrates precise spatiotemporal mi RNA detection and exhibits excellent biocompatibility,enabling specific mi RNA recognition"on demand"within cancer cells.This research presents a reliable mi RNA imaging platform in the intricate cellular environment,opening up the possibilities for precise biomedical analysis and disease diagnosis.
基金supported by National Natural Science Foundation of China(Nos.12072381,22072185,21805315)Guangdong Basic and Applied Basic Research Foundation(No.2024A1515011812)Science and Technology Innovation Project of Guangzhou(No.202102020263).
文摘On-demand droplet manipulation plays a critical role in microfluidics,bio/chemical detection and microreactions.Acoustic droplet manipulation has emerged as a promising technique due to its non-contact nature,biocompatibility and precision,circumventing the complexities associated with other methods requiring surface or droplet pretreatment.Despite their promise,existing methods for acoustic droplet manipulation often involve complex hardware setups and difficulty for controlling individual droplet amidst multiple ones.Here we fabricate simple yet effective acoustic tweezers for in-surface and out-of-surface droplet manipulation.It is found that droplets can be transported on the superhydrophobic surfaces when the acoustic radiation force surpasses the friction force.Using a two-axis acoustic tweezer,droplets can be maneuvered along arbitrarily programmed paths on the surfaces.By introducing multiple labyrinthine structures on the superhydrophobic surface,individual droplet manipulation is realized by constraining the unselected droplets in the labyrinthine structures.In addition,a three-axis acoustic tweezer is developed for manipulating droplets in three-dimensional space.Potential applications of the acoustic tweezers for micro-reaction,bio-assay and chemical analysis are also demonstrated.
基金supported by the National Natural Science Foundation of China(Nos.52025132,U24A20205,52303373,21621091,22021001,and 22121001)the China Postdoctoral Science Foundation(No.2024M763174)+2 种基金the 111 Project(Nos.B17027,B16029)the Natural Science Foundation of Fujian Province of China(No.2022J02059)the New Cornerstone Science Foundation through the Xplorer Prize。
文摘Controllable liquid manipulation is of paramount scientific and technological importance in various fields,such as the chemical industry,biomedicine,and agricultural production.Magnetic actuation,characterized by rapid,contactless,and environmentally benign operation,has emerged as a promising approach for precise liquid control.However,conventional magnetic strategies typically govern droplet movement on open surfaces,facing limitations such as restricted liquid volumes,uncertain flow paths,and inevitable evaporation,thereby constraining their broader practical applications.Recently,a variety of magneticdriven strategies have been developed to dynamically regulate liquids within enclosed spaces,especially through physicochemical mechanisms.These approaches provide efficient control over liquid behavior by leveraging magnetically induced chemical changes,structural deformations,and dragging motions,opening new opportunities for flexible and versatile fluid management.This review explores the design and mechanisms of magneto-responsive confined interfaces for the manipulation of nonmagnetic liquids,highlighting key advancements and potential applications including liquid valves,liquid mixing,liquid flow regulation,and liquid pumping.Finally,the existing challenges and future prospects in this field are presented.
基金funded in part by the Natural Sciences and Engineering Research Council of Canada(RGPIN 024042021 and CGS D-534891-2019)the NSERC CREATE Wearable Technology Research and Collaboration training program(graduate fellowship and undergraduate summer research fellowship).
文摘Purpose:This study aimed to evaluate the relationship between peak tibial acceleration and peak ankle joint contact forces in response to stride length manipulation during level-ground running.Methods:Twenty-seven physically active participants ran 10 trials at preferred speed in each of 5 stride length conditions:preferred,±5%,and±10%of preferred stride length.Motion capture,force platform,and tibial acceleration data were directly measured,and ankle joint contact forces were estimated using an inverse-dynamics-based static optimization routine.Results:In general,peak axial tibial accelerations(p<0.001)as well as axial(p<0.001)and resultant(p<0.001)ankle joint contact forces increased with stride length.When averaged within the 10 strides of each stride condition,moderate positive correlations were observed between peak axial acceleration and joint contact force(r=0.49)as well as peak resultant acceleration and joint contact force(r=0.51).However,37%of participants illustrated either no relationship or negative correlations.Only weak correlations across participants existed between peak axial acceleration and joint contact force(r=0.12)as well as peak resultant acceleration and ankle joint contact force(r=0.18)when examined on a step-by-step basis.Conclusion:These results suggest that tibial acceleration should not be used as a surrogate for ankle joint contact force on a step-by-step basis in response to stride length manipulations during level-ground running.A 10-step averaged tibial acceleration metric may be useful for some runners,but an initial laboratory assessment would be required to identify these individuals.
基金National Natural Science Foundation of China(61703363)Shanxi Provincial Basic Research Program(202403021221206)+2 种基金Key Project of Shanxi Provincial Strategic Research on Science and Technology(202304031401011)Funding Project for Scientific Research Innovation Team on Data Mining and Industrial Intelligence Applications(YCXYTD-202402)Yuncheng University Research Project(YQ-2020021)。
文摘In existing image manipulation localization methods,the receptive field of standard convolution is limited,and during feature transfer,it is easy to lose high-frequency information about traces of manipulation.In addition,during feature fusion,the use of fixed sampling kernels makes it difficult to focus on local changes in features,leading to limited localization accuracy.This paper proposes an image manipulation localization method based on dual-branch hybrid convolution.First,a dual-branch hybrid convolution module is designed to expand the receptive field of the model to enhance the feature extraction ability of contextual semantic information,while also enabling the model to focus more on the high-frequency detail features of manipulation traces while localizing the manipulated area.Second,a multiscale content-aware feature fusion module is used to dynamically generate adaptive sampling kernels for each position in the feature map,enabling the model to focus more on the details of local features while locating the manipulated area.Experimental results on multiple datasets show that this method not only effectively improves the accuracy of image manipulation localization but also enhances the robustness of the model.
基金supported by the National Natural Science Foundation of China(No.52075249)the Tianyuan Laboratory Fund(No.24-JSKY-ZZKT-14).
文摘In the fields of optoelectronics and semiconductors, reliable fixation and handling of brittle materials (glass, wafer, etc.) in high-temperature, vacuum, and vibration environments face particular technical challenges. These challenges include the inability of suction cups in a vacuum, the residue of chemical adhesives, and the easy damage of mechanical clamping. In this paper, fluorine-based bionic adhesive pads (FBAPs) obtained using molding technology to imitate gecko micropillar arrays are presented. FBAPs inhibit the substantial decay of adhesive properties at high temperatures and provide stable and reliable performance in vacuum and vibration environments. The results demonstrated that the decayed force values of the normal and tangential strength of the FBAP were only 9.01% and 5.82% of the planar samples when warmed up to 300℃ from 25℃, respectively. In a vacuum, all FBAPs exhibit less than 20% adhesion attenuation, and in a vibrational environment, they can withstand accelerations of at least 4.27 g. The design of the microstructure arrays enables the realization of efficient and non-destructive separation through mechanical rotation or blowing. It provides a bionic material basis for the fixation of brittle materials on smooth surfaces under complex environments and for transportation automation.
基金supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region under Grant No.2023D01C21the National Natural Science Foundation of China under Grant No.62362063.
文摘Existing image manipulation localization(IML)techniques require large,densely annotated sets of forged images.This requirement greatly increases labeling costs and limits a model’s ability to handle manipulation types that are novel or absent from the training data.To address these issues,we present CLIP-IML,an IML framework that leverages contrastive language-image pre-training(CLIP).A lightweight feature-reconstruction module transforms CLIP token sequences into spatial tensors,after which a compact feature-pyramid network and a multi-scale fusion decoder work together to capture information from fine to coarse levels.We evaluated CLIP-IML on ten public datasets that cover copy-move,splicing,removal,and artificial intelligence(AI)-generated forgeries.The framework raises the average F1-score by 7.85%relative to the strongest recent baselines and secures either the first-or second-place performance on every dataset.Ablation studies show that CLIP pre-training,higher resolution inputs,and the multi-scale decoder each make complementary contributions.Under six common post-processing perturbations,as well as the compression pipelines used by Facebook,Weibo,and WeChat,the performance decline never exceeds 2.2%,confirming strong practical robustness.Moreover,CLIP-IML requires only a few thousand annotated images for training,which markedly reduces data-collection and labeling effort compared with previous methods.All of these results indicate that CLIP-IML is highly generalizable for image tampering localization across a wide range of tampering scenarios.
基金Supported by Hospital-level Project of Shiyan Taihe Hospital(2018JJXM093).
文摘[Objectives]To investigate the therapeutic effects of combined treatment on children diagnosed with pseudomyopia,based on the theoretical framework that the liver is associated with eye health in traditional Chinese medicine.[Methods]A multicenter randomized controlled trial was conducted involving 100 children,with the treatment group consisting of 50 participants receiving a combined treatment,while the control group,also comprising 50 participants,received conventional tuina.In the treatment group,the Yizhichan Pushing Manipulation was applied at a frequency of 120 times/min and a strength of 0.5-1.0 kg,targeting acupoints such as Ganyu and Guangming.The alterations in naked eye visual acuity,diopter measurements,and ciliary muscle regulation function were compared between the two groups of children both prior to and following treatment,and the clinical efficacy was assessed.[Results]The treatment group demonstrated a statistically significant enhancement in visual acuity(1.74±0.49 lines vs.1.02±0.52 lines),diopter improvement(0.91±0.29 D vs.0.46±0.25 D),and overall efficiency(96%vs.78%)when compared to the control group(all P<0.01).[Conclusions]This combined treatment exerts a therapeutic effect through a dual mechanism that involves the regulation of liver meridian qi and blood,as well as the enhancement of ciliary muscle function.This approach merits further dissemination and application in the prevention and management of myopia in children.
基金supported by Westlake Universitythe Research Center for Industries of the Future of Westlake University (No. WU2022C040).
文摘The complexity and intricacy of the brain,which is composed of billions of neurons,pose significant challenges to its study.Understanding neural connections and communication at the single-cell level is crucial for unraveling the brain’s functions.This study presents a novel strategy that utilizes magnetic nanoparticles(MNPs)and magnetic fields to manipulate neurons,thereby creating customized small-scale neural circuits for studying neural connections.To establish the feasibility of this approach,the effects of MNPs on neurons were initially investigated,demonstrating their low toxicity.Subsequently,a micromagnet array(MMA)chip was employed to manipulate the neurons,facilitating their precise arrangement on the electrodes.Over several days,the neurons extended their axons and established connections with neighboring cells,forming small-scale circular neural circuits.These artificially engineered circuits offer a simplified and controlled environment for studying neural networks in contrast to naturally occurring biological networks.Furthermore,electrophysiological recordings were conducted to investigate the connections between the manipulated neurons.This study introduces a customized small-scale neural circuit platform with electrode-specific recording and stimulating capabilities,enabling the study of neuron-to-neuron interactions at the single-cell level.By leveraging MNPs and an MMA chip,this research offers a powerful tool for studying neural connections and advancing our understanding of the brain’s intricate workings.
基金funded by the National Natural Science Foundation of China(Project No.62273289)The Youth Innovation Science and Technology Support Program of Shandong Province(Project No.2022KJ274)+1 种基金Natural Science Foundation of Shandong Province(Grant No.ZR2024MF007)Graduate Innovation Foundation of Yantai University,GIFYTU.
文摘The design and manufacturing of microchannels are crucial aspects of modern micro/nanomanufacturing processes,offering a versatile platform for manipulating and driving micro/nanoparticles or cells.In this study,we propose a method for manufacturing microchannels using optically induced dielectrophoresis technology to induce the polymerization of polyethylene glycol diacrylate solution.To overcome limitations related to the light intensity energy and the size of intact microchannels,we design and manufacture microstructures of various shapes with a height of 4µm.Additionally,we simulate and analyze the movement of and forces acting on polystyrene(PS)microspheres at different spatial positions within the microchannels.Finally,we successfully demonstrate applications involving the transport of PS microspheres in custom-fabricated microchannels.This novel biocompatible microchannel manufacturing method is simple and non-biotoxic.It provides a new approach for simulating physiological environments in vitro and cultivating and manipulating cells.
基金supported by the National Key R&D Program of China(Grant No.2023YFB2905503)the National Natural Science Foundation of China(Grant Nos.62035016,62105200,62475146,and 62341508).
文摘Coupled-waveguide devices are essential in photonic integrated circuits for coupling,polarization handling,and mode manipulation.However,the performance of these devices usually suffers from high wavelength and structure sensitivity,which makes it challenging to realize broadband and reliable on-chip optical functions.Recently,topological pumping of edge states has emerged as a promising solution for implementing robust optical couplings.In this paper,we propose and experimentally demonstrate broadband on-chip mode manipulation with very large fabrication tolerance based on the Rice–Mele modeled silicon waveguide arrays.The Thouless pumping mechanism is employed in the design to implement broadband and robust mode conversion and multiplexing.The experimental results prove that various mode-order conversions with low insertion losses and intermodal crosstalk can be achieved over a broad bandwidth of 80 nm ranging from 1500 to 1580 nm.Thanks to such a topological design,the device has a remarkable fabrication tolerance of±70 nm for the structural deviations in waveguide width and gap distance,which is,to the best of our knowledge,the highest among the coupled-waveguide mode-handling devices reported so far.As a proof-of-concept experiment,we cascade the topological mode-order converters to form a four-channel mode-division multiplexer and demonstrate the transmission of a 200-Gb/s 16-quadrature amplitude modulation signal for each mode channel,with the bit error rates below the 7%forward error correction threshold of 3.8×10^(-3).We reveal the possibility of developing new classes of broadband and fabrication-tolerant coupled-waveguide devices with topological photonic approaches,which may find applications in many fields,including optical interconnects,quantum communications,and optical computing.
基金Project supported by the National Key Research&Development Program of China(Grant Nos.2019YFA0308600 and 2020YFA0309000)the National Natural Science Foundation of China(Grant Nos.92365302,92065201,22325203,92265105,12074247,12174252,52102336)+2 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB28000000)the Science and Technology Commission of Shanghai Municipality(Grant Nos.2019SHZDZX01,19JC1412701,20QA1405100,24LZ1401000,LZPY2024-04)financial support from the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0302500)。
文摘Manipulating and braiding Majorana zero modes(MZM)are a critical step toward realizing topological quantum computing.The primary challenge is controlling the vortex,which hosts the MZM,within a superconducting film in a spatially precise manner.To address this,we developed a magnetic force-based vortex control technology using the STM system with a self-designed four-electrode piezo-scanner tube and investigated vortex manipulation on the NbSe_(2) superconducting film.We employed ferromagnetic tips to control the movement of vortex array induced by the tip's remanent magnetism.A magnetic core solenoid device was integrated into the STM system and a strong magnetic tip demagnetization technique was developed,providing a viable technical solution for further enabling single vortex manipulation.
基金This work was supported by the National Natural Science Foundation of China(Grants Nos.12222214,12132020,12002400,and 12172386)by Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices(Grant No.2022B1212010008)+1 种基金by the National Natural Science Foundation of Guangdong Province(Grant No.2021B1515020021)by the Shenzhen Science and Techonlogy Program(Grant Nos.202206193000001 and 20220818181805001).
文摘Transient negative capacitance(NC),as an available dynamic charge effect achieved in resistor-ferroelectric capacitor(R-FEC)circuits,has triggered a series of theoretical and experimental works focusing on its physical mechanism and device application.Here,we analytically derived the effects of different mechanical conditions on the transient NC behaviors in the R-FEC circuit based on the phenomenological model.It shows that the ferroelectric capacitor can exhibit either NC(i.e.,“single NC”and“double NC”)or positive capacitance,depending on the mechanical condition and temperature.Further numerical calculations show that the voltage drop caused by NC can be effectively controlled by temperature,applied stress,or strain.The relationship between NC voltage drop and system configurations including external resistance,dynamical coefficient of polarization,and input voltage are presented,showing diverse strategies to manipulate the NC effect.These results provide theoretical guidelines for rational design and efficient control of NC-related electronic devices.
