To the Editor:Pancreatic acinar cell carcinoma(PACC),with primary compo-nent similar to acinar cells,represents merely 1%-2%of pancreatic exocrine neoplasms[1].As a high-grade malignancy,PACC has the potential to mani...To the Editor:Pancreatic acinar cell carcinoma(PACC),with primary compo-nent similar to acinar cells,represents merely 1%-2%of pancreatic exocrine neoplasms[1].As a high-grade malignancy,PACC has the potential to manifest in any anatomical region of the pancreas,while mostly in the head of the pancreas[2].The initial symptoms of PACC may not be obvious.Upon diagnosis,the tumor typi-cally manifests as a substantial size,resulting in compression of adjacent organs and subsequent non-specific gastrointestinal mani-festations.These complications encompass abdominal pain,nausea,diarrhea,and weight loss[3].Nevertheless,the incidence of bile duct obstruction and jaundice is relatively modest.Despite being classified as an aggressive tumor,PACC exhibits a slightly slower disease progression compared to pancreatic ductal adenocarcinoma(PDAC).Currently,the median survival of PACC ranges from 18 to 47 months[4].Here,we presented a unique occurrence of PACC with liver metastases,aiming to enhance comprehension of the disease and diminish the probability of misdiagnosis.展开更多
Aim: Investigation whether the signal intensity of hepatocellular carcinoma (HCC) on dynamic magnetic resonance imaging (MRI) with hepatocellular contrast medium (CM) correlates with the histologic malignancy grade an...Aim: Investigation whether the signal intensity of hepatocellular carcinoma (HCC) on dynamic magnetic resonance imaging (MRI) with hepatocellular contrast medium (CM) correlates with the histologic malignancy grade and cytometric DNA index. Material and Methods: MRI at 1.5 T with hepatocellular CM Gd-DTPA-EOB of 63 patients (52 men, 11 women;64.0 ± 8.5 years) with HCC in cirrhosis. SI of the tumor and liver tissue in sequences (T1, T1fs, T2fs, T1fs + CM (arterial, venous, late venous phase) were correlated like the asymmetry coefficient of the SI in the arterial and venous phases respective the native and late venous phases of the tumor with the histologic malignancy grade and DNA index indicating the grade of abnormal DNA steam line respective aneuploid DNA. Results: SI did not significantly correlate with the histologic malignancy grade or DNA index for precontrast or postcontrast images. There is a significant correlation for the asymmetry coefficient of the SI in the arterial and venous phases with the DNA-index (p values of 0.00089 (Pearson) and 0.0082 (Spearman). Conclusion: A highly arterialized hepatocellular carcinoma with rapid washout in the venous phase corresponds to a higher malignant potential. These findings suggest that the MR parameters investigated here may predict the malignant potential and prognosis of HCC before surgery.展开更多
Solid pseudopapillary neoplasm(SPN)of the pancreas is a low-grade malignant tumor,representing 0.9%to 2.7%of exocrine pancreatic tumors and only 5%of cystic pan-creatic tumors.^([1])These tumors are heterogenous with ...Solid pseudopapillary neoplasm(SPN)of the pancreas is a low-grade malignant tumor,representing 0.9%to 2.7%of exocrine pancreatic tumors and only 5%of cystic pan-creatic tumors.^([1])These tumors are heterogenous with variable solid and pseudopapillary areas.The characteristic features of SPN are poorly cohesive epithelial cells forming papillary-like structures on myxoid or hyalinized vascular stalk.展开更多
基金supported by a grant from the National Natural Science Foundation of China(82202974).
文摘To the Editor:Pancreatic acinar cell carcinoma(PACC),with primary compo-nent similar to acinar cells,represents merely 1%-2%of pancreatic exocrine neoplasms[1].As a high-grade malignancy,PACC has the potential to manifest in any anatomical region of the pancreas,while mostly in the head of the pancreas[2].The initial symptoms of PACC may not be obvious.Upon diagnosis,the tumor typi-cally manifests as a substantial size,resulting in compression of adjacent organs and subsequent non-specific gastrointestinal mani-festations.These complications encompass abdominal pain,nausea,diarrhea,and weight loss[3].Nevertheless,the incidence of bile duct obstruction and jaundice is relatively modest.Despite being classified as an aggressive tumor,PACC exhibits a slightly slower disease progression compared to pancreatic ductal adenocarcinoma(PDAC).Currently,the median survival of PACC ranges from 18 to 47 months[4].Here,we presented a unique occurrence of PACC with liver metastases,aiming to enhance comprehension of the disease and diminish the probability of misdiagnosis.
文摘Aim: Investigation whether the signal intensity of hepatocellular carcinoma (HCC) on dynamic magnetic resonance imaging (MRI) with hepatocellular contrast medium (CM) correlates with the histologic malignancy grade and cytometric DNA index. Material and Methods: MRI at 1.5 T with hepatocellular CM Gd-DTPA-EOB of 63 patients (52 men, 11 women;64.0 ± 8.5 years) with HCC in cirrhosis. SI of the tumor and liver tissue in sequences (T1, T1fs, T2fs, T1fs + CM (arterial, venous, late venous phase) were correlated like the asymmetry coefficient of the SI in the arterial and venous phases respective the native and late venous phases of the tumor with the histologic malignancy grade and DNA index indicating the grade of abnormal DNA steam line respective aneuploid DNA. Results: SI did not significantly correlate with the histologic malignancy grade or DNA index for precontrast or postcontrast images. There is a significant correlation for the asymmetry coefficient of the SI in the arterial and venous phases with the DNA-index (p values of 0.00089 (Pearson) and 0.0082 (Spearman). Conclusion: A highly arterialized hepatocellular carcinoma with rapid washout in the venous phase corresponds to a higher malignant potential. These findings suggest that the MR parameters investigated here may predict the malignant potential and prognosis of HCC before surgery.
文摘Solid pseudopapillary neoplasm(SPN)of the pancreas is a low-grade malignant tumor,representing 0.9%to 2.7%of exocrine pancreatic tumors and only 5%of cystic pan-creatic tumors.^([1])These tumors are heterogenous with variable solid and pseudopapillary areas.The characteristic features of SPN are poorly cohesive epithelial cells forming papillary-like structures on myxoid or hyalinized vascular stalk.
