To the Editor:Melanoma is the most aggressive and lethal cutaneous malignancy,with its incidence increasing annually.Surgical resection is effective for early-stage melanoma;however,therapeutic strategies for metastat...To the Editor:Melanoma is the most aggressive and lethal cutaneous malignancy,with its incidence increasing annually.Surgical resection is effective for early-stage melanoma;however,therapeutic strategies for metastatic melanoma are limited by poor prognosis and adverse effects.[1]Our research team previously screened six compounds(Sanggenon C,Kuwanon A[KA],Kuwanon E,Moracin O,Moracin P,and 3′-geranyl-3-prenyl-2′,4′,5,7-tetrahydroxyflavone)with strong anti-melanoma effects from 28 compounds in Morus alba L.We focused on KA,whose structure is shown in Supplementary Figure 1A,http://links.lww.com/CM9/C458 with anti-inflammatory,antioxidant,and anticancer properties.[2,3]Its anti-tumor mechanisms in melanoma remain unclear.展开更多
To the Editor:Basal cell carcinoma(BCC)is the most prevalent skin malignancy,with an increasing incidence and economic burden worldwide.[1]Various histopathological subtypes of BCC have been well described,and subtype...To the Editor:Basal cell carcinoma(BCC)is the most prevalent skin malignancy,with an increasing incidence and economic burden worldwide.[1]Various histopathological subtypes of BCC have been well described,and subtype confirmation is essential for BCC classification according to the risk of recurrence.[2]Early diagnosis and intervention are important,especially considering that the incidence of aggressive subtypes of BCC is increasing faster than that of indolent subtypes.展开更多
基金This study was supported by a grant from the Natural Science Foundation of Hebei Province(No.H2022206328).
文摘To the Editor:Melanoma is the most aggressive and lethal cutaneous malignancy,with its incidence increasing annually.Surgical resection is effective for early-stage melanoma;however,therapeutic strategies for metastatic melanoma are limited by poor prognosis and adverse effects.[1]Our research team previously screened six compounds(Sanggenon C,Kuwanon A[KA],Kuwanon E,Moracin O,Moracin P,and 3′-geranyl-3-prenyl-2′,4′,5,7-tetrahydroxyflavone)with strong anti-melanoma effects from 28 compounds in Morus alba L.We focused on KA,whose structure is shown in Supplementary Figure 1A,http://links.lww.com/CM9/C458 with anti-inflammatory,antioxidant,and anticancer properties.[2,3]Its anti-tumor mechanisms in melanoma remain unclear.
基金This work was supported by grants from CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2022-I2M-C&T-A-007)the National Natural Science Foundation of China(No.92354307)the Fundamental Research Funds for the Central Universities(No.2023RC09).
文摘To the Editor:Basal cell carcinoma(BCC)is the most prevalent skin malignancy,with an increasing incidence and economic burden worldwide.[1]Various histopathological subtypes of BCC have been well described,and subtype confirmation is essential for BCC classification according to the risk of recurrence.[2]Early diagnosis and intervention are important,especially considering that the incidence of aggressive subtypes of BCC is increasing faster than that of indolent subtypes.
