Background:Prostate cancer(PCa)patients are at risk of developing second primary malignancies(SPMs),which can significantly shorten their survival.Understanding the risk of SPMs and associated factors is crucial to th...Background:Prostate cancer(PCa)patients are at risk of developing second primary malignancies(SPMs),which can significantly shorten their survival.Understanding the risk of SPMs and associated factors is crucial to the optimization of patient follow-up.Methods:This study focuses on PCa patients who were later diagnosed with SPMs using data from the Surveillance,Epidemiology,and End Results(SEER)database.Variables were carefully selected,and the data were analyzed using machine learning techniques combined with mul-tivariate Cox proportional hazards modeling.Subsequently,a nomogram was generated to predict the 1-,3-,and 5-year survival rates for SPMs patients.Additionally,a two-sample Mendelian randomization(TSMR)analysis was conducted to investigate the causal relationships between PCa and its top ten SPMs.Results:Among the variables,age,marital status,SPM site,M stage,American Joint Committee on Cancer(AJCC)stage,PCa surgery,and prostate-specific antigen(PSA)levels were identified as key prognostic factors through least absolute shrinkage and selection operator(LASSO)and backward stepwise regression.Based on these factors,a nomogram was developed to visually represent survival predictions,complemented by a web-based calculator for easy application.This nomogram,which serves as a supplement to traditional AJCC staging,demonstrated strong predictive power for 1-,3-,and 5-year survival,with area under the curve(AUC)values exceeding 0.85.Additionally,TSMR analysis revealed a causal link between PCa and urothelial carcinoma(UC).Conclusion:This study developed a nomogram for predicting survival in prostate cancer patients with secondary primary malignancies,enhancing prognosis accuracy.TSMR identified a causal link between PCa and UC.展开更多
BACKGROUND Resilience is an individual’s ability and psychological rebound capacity to adapt well after experiencing adversity,trauma,etc.Patients with strong resilience can face illnesses actively.AIM To determine t...BACKGROUND Resilience is an individual’s ability and psychological rebound capacity to adapt well after experiencing adversity,trauma,etc.Patients with strong resilience can face illnesses actively.AIM To determine the association of resilience with coping styles and quality of life in patients with malignancies.METHODS This study included patients with malignant tumors who were hospitalized at Fuyang Hospital Affiliated to Anhui Medical University from March 2022 to March 2024.The Connor-Davidson Resilience Scale,Medical Coping Modes Questionnaire,Social Support Rating Scale,and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 were utilized to assess patients’resilience,coping styles,social support,and quality of life,respectively.Pearson correlation analysis was conducted to assess the correlations.RESULTS A total of 175 patients with malignant tumors demonstrated no marked difference in terms of age,education level,employment status,monthly household income,and disease staging(P<0.05).Further,patients with malignancies demonstrated scores of 17.49±1.20,17.27±1.46,and 11.19±1.29 points in terms of coping styles in confrontation,avoidance,and resignation dimensions,respectively.Subjective support,objective support,and support utilization scores in terms of social support were 10.67±1.80,11.26±2.08,and 9.24±1.14 points,respectively.The total resilience score and tenacity,self-improvement,and optimism dimension scores were positively correlatedwith the confrontation coping style score,whereas the total resilience score and tenacity and self-improvementscores were negatively associated with avoidance and resignation coping style scores(P<0.05).The total resiliencescore and the tenacity dimension score were positively associated with physical,role,cognitive,emotional,andsocial functions,as well as global health status(P<0.05),and were inversely related to fatigue,insomnia,andeconomic difficulties(P<0.05).CONCLUSIONThe resilience of patients with malignancies is positively associated with the confrontation dimension in the copingstyle,the total and various social support domain scores,and the overall quality of life.Clinical medical staff needto pay attention to the effect of medical coping styles and social support on the resilience level of patients withmalignancies to further improve their quality of life.展开更多
Liver transplantation(LT)is the definitive treatment for end-stage liver disease,acute liver failure,and liver cancer.Although advancements in surgical techniques,postoperative care,and immunosuppressive therapies hav...Liver transplantation(LT)is the definitive treatment for end-stage liver disease,acute liver failure,and liver cancer.Although advancements in surgical techniques,postoperative care,and immunosuppressive therapies have significantly improved outcomes,the long-term use of immunosuppression has increased the risk of complications,including infections,cardiovascular disease,and cancer.Among these,de novo malignancies(DNMs)are a major concern,accounting for 20%-25%of deaths in LT recipients surviving beyond the early post-transplant period.Non-melanoma skin cancers,particularly squamous cell carcinoma are the most prevalent DNMs.Other significant malignancies include Kaposi's sarcoma,post-transplant lymphoproliferative disorders,and various solid organ cancers,including head and neck cancers.Compared to the general population,LT patients face a twofold increase in solid organ malignancies and a 30-fold increase in lymphoproliferative disorders.Risk factors for DNM include chronic immunosuppression,alcohol or tobacco use,viral infections,and underlying liver disease.Emerging evidence emphasizes the importance of tailored cancer screening and prevention strategies,including regular dermatological examinations,targeted screenings for high-risk cancers,and patient education on lifestyle modifications.Early detection through enhanced surveillance protocols has been shown to improve outcomes.Management of DNMs involves a combination of standard oncological therapies and adjustments to immunosuppressive regimens,with promising results from the use of mTOR inhibitors in select patients.The review highlights the critical need for ongoing research to refine risk stratification,optimize screening protocols,and improve treatment approaches to mitigate the burden of DNMs in LT recipients.By implementing personalized preventive and therapeutic strategies,we can enhance long-term outcomes and quality of life for this vulnerable population.展开更多
In this editorial,we comment on the article by Qin et al,recently published in the World Journal of Gastrointestinal Oncology.Malignant tumors of the digestive tract represent a significant health threat.Kinesin famil...In this editorial,we comment on the article by Qin et al,recently published in the World Journal of Gastrointestinal Oncology.Malignant tumors of the digestive tract represent a significant health threat.Kinesin family member 14(KIF14),a critical kinesin,is pivotal in the proliferation,migration,and invasion of tumor cells.It has emerged as a focal point in recent studies of malignant tumors in the digestive tract.This article reviews the current research on KIF14 within these tumors and details its significant role in tumor cell behaviors,including proliferation,apo-ptosis,migration,invasion,and angiogenesis,alongside the regulatory mechanisms of the associated intracellular signaling pathways.Additionally,it explores the clinical value of KIF14 as a potential biomarker for early diagnosis,disease monitoring,and prognostic evaluation in malignant tumors of the digestive tract.The article concludes by introducing the potential regulatory role of traditional Chinese medicine,aiming to combine the strengths of both modern and traditional medical approaches to enhance treatment outcomes and prognosis for patients with these tumors.展开更多
Hematologic malignancies,including leukemia,lymphoma,and multiple myeloma,are hazardous diseases characterized by the uncontrolled proliferation of cancer cells.Dysregulated cell cycle resulting from genetic and epige...Hematologic malignancies,including leukemia,lymphoma,and multiple myeloma,are hazardous diseases characterized by the uncontrolled proliferation of cancer cells.Dysregulated cell cycle resulting from genetic and epigenetic abnormalities constitutes one of the central events.Importantly,cyclin-dependent kinases(CDKs),complexed with their functional partner cyclins,play dominating roles in cell cycle control.Yet,efforts in translating CDK inhibitors into clinical benefits have demonstrated disappointing outcomes.Recently,mounting evidence highlights the emerging significance of WEE1 G2 checkpoint kinase(WEE1)to modulate CDK activity,and correspondingly,a variety of therapeutic inhibitors have been developed to achieve clinical benefits.Thus,WEE1 may become a promising target to modulate the abnormal cell cycle.However,its function in hematologic diseases remains poorly elucidated.In this review,focusing on hematologic malignancies,we describe the biological structure of WEE1,emphasize the latest reported function of WEE1 in the carcinogenesis,progression,as well as prognosis,and finally summarize the therapeutic strategies by targeting WEE1.展开更多
Background:Second primary malignancies(SPMs)account for over 30%of total deaths in head and neck cancer(HNC)patients.The increasing use of radiotherapy raises concerns about the elevated risk of radiation-associated S...Background:Second primary malignancies(SPMs)account for over 30%of total deaths in head and neck cancer(HNC)patients.The increasing use of radiotherapy raises concerns about the elevated risk of radiation-associated SPMs.This study aimed to investigate the age-stratified association between radiotherapy and SPM risk in survivors of non-metastatic primary HNC.Methods:Using data from the Surveillance,Epidemiology,and End Results program(2004-2015),incidence rate ratios(IRRs)and standardized incidence ratios(SIRs)were evaluated for solid and hematologic SPMs associated with radiotherapy within different age groups.Follow-up for hematologic and solid SPMs began 2 and 5 years,respectively,after the diagnosis of first primary HNC.The IRRs for SPMs were compared between radiotherapy-exposed and unexposed groups using multivariable modified Poisson regression.The SIRs were computed as the ratio of observed cancers in the cohort to expected cases derived from sex-,age-,and calendar year-matched general population incidence rates.Results:The study included 75,2092-year survivors,with 73.2%being male and a median age of 60 years.Of these,58,063 had survived 5 years or more.Radiotherapy was associated with an increased risk of solid SPMs[IRR=1.16,95%confidence interval(CI)1.08-1.24;P<0.001].The associations varied significantly among young(aged 15-39 years),middle-aged(aged 40-64 years),and elderly(aged 65-89 years)patients.Specifically,radiotherapy was associated with an increased risk of solid SPMs in middle-aged patients(IRR=1.21,95%CI 1.11-1.32;P<0.001),and a decreased risk of hematologic SPMs in elderly patients(IRR=0.77,95%CI 0.60-0.99;P=0.045).Compared with the general population,young patients had an elevated risk of radiotherapy-associated second primary non-Hodgkin lymphoma(SIR=4.01,95%CI 1.47-8.74).Middle-aged patients showed the highest SIR for SPMs in the bones/joints(SIR=7.72,95%CI 4.32-12.73),while elderly patients had the highest SIR for second primary esophageal malignancies(SIR=3.87,95%CI 2.91-5.05).Males were more likely to develop solid SPMs compared to females.Conclusions:This study reveals an age-stratified association between radiotherapy and the risk of SPMs in HNC patients.These findings highlight the importance of considering patient age when making treatment decisions for HNC and suggest that long-term surveillance is necessary for high-risk groups.展开更多
BACKGROUND Cytoreductive surgery(CRS)combined with hyperthermic intraperitoneal chemotherapy(HIPEC)has become an established treatment for selected patients with peritoneal metastases(PM)from colorectal,ovarian,and ga...BACKGROUND Cytoreductive surgery(CRS)combined with hyperthermic intraperitoneal chemotherapy(HIPEC)has become an established treatment for selected patients with peritoneal metastases(PM)from colorectal,ovarian,and gastric cancers,as well as for certain primary peritoneal tumors such as pseudomyxoma peritonei.However,evidence supporting its role in other uncommon indications remains limited,largely due to the rarity and heterogeneity of these malignancies and the absence of standardized treatment protocols.Understanding the potential survival benefit and safety profile of CRS+HIPEC in these contexts may help refine patient selection and guide clinical decision-making.AIM To evaluate surgical and oncologic outcomes,particularly overall survival(OS),in this heterogeneous patient population and assess perioperative morbidity and mortality to better define the safety profile of this aggressive multimodal strategy.METHODS We retrospectively reviewed data from five tertiary cancer centers on patients who underwent CRS+HIPEC between January 2004 and December 2021 for PM from uncommon histologies,defined as any primary tumor other than colorectal,gastric,or ovarian carcinomas,pseudomyxoma peritonei,or malignant peritoneal mesothelioma.Baseline characteristics,operative details,complications(graded by the Clavien-Dindo classification),and survival outcomes were analyzed.OS was estimated using Kaplan-Meier analysis.Prognostic factors were evaluated using univariate and multivariate Cox proportional hazards models.The discriminatory ability and overall fit of the final model were assessed by the concordance index(C-index)and likelihood ratio test,respectively.RESULTS A total of 60 CRS+HIPEC procedures were performed in 60 patients(mean age=58.5 years,78.3%female).The most frequent primary tumors were uterine(35%)and breast cancer(20%).Median operative time was 405 minutes,and 75%of patients required perioperative transfusions.Major complications(Clavien-Dindo≥3)occurred in 21.6%of patients,and 90-day mortality was 1.6%.Median OS for the entire cohort was 28 months.Kaplan-Meier analysis showed that breast cancer patients achieved the longest survival(median OS=75 months)compared with uterine cancer(32 months)and other primaries(17 months).Multivariate analysis confirmed tumor origin as the strongest independent predictor of OS(C-index=0.81;likelihood ratio test=40.07;P<0.001).CONCLUSION Our findings suggest that CRS+HIPEC can be performed safely in highly selected patients with PM from uncommon primary tumors,achieving meaningful long-term survival in subsets such as breast and uterine cancers.Tumor biology,rather than clinical factors,emerged as the key determinant of survival.Given the rarity and heterogeneity of these malignancies,collaborative multicenter efforts and prospective registries are essential to establish standardized selection criteria and optimize outcomes.展开更多
Objective:To explore the epidemiological trends and clinical presentations of brucellosis in patients diagnosed with different types of cancer.Methods:A systematic review was performed utilizing PubMed,Embase,Scopus,W...Objective:To explore the epidemiological trends and clinical presentations of brucellosis in patients diagnosed with different types of cancer.Methods:A systematic review was performed utilizing PubMed,Embase,Scopus,Web of Science,and Google Scholar following PRISMA guidelines until September 2022.An update in December 2023 was conducted to ensure thorough coverage of the literature.Results:A total of 28 articles met the eligibility criteria,reporting 38 cases of brucellosis in patients with cancer.Among these cases,hematological cancers were the most common,comprising 66%of the cases,and B.melitensis was identified as the predominant species.The primary clinical manifestations of brucellosis infection included constitutional symptoms in a notable 60.5%of cases and febrile neutropenia in 21%.Additionally,six cases(15.8%)experienced relapse or recurrence of brucellosis,all of which were managed using a combination therapy of rifampin and doxycycline.While 28 patients successfully achieved remission from both brucellosis and their underlying neoplastic conditions,unfortunately,nine cases resulted in mortality attributed to septic shock,progressive liver failure,and massive embolism;no deaths directly related to brucellosis were reported.Among the non-surviving cases,hematologic malignancies were the most prevalent neoplastic conditions(77.7%).Conclusions:Brucellosis-cancer co-occurrence is rare but is not related to increasing mortality.The risk of relapse is higher in cancer patients,especially with hematologic malignancies.Screening,monitoring,and judicious antibiotic use can mitigate brucellosis risks in neoplastic patients.展开更多
Objective:To analyze body composition measurements and explore their correlation with the nutritional risk screening score and neutrophil-to-lymphocyte ratio(NLR;an index of inflammation)to provide a basis for the per...Objective:To analyze body composition measurements and explore their correlation with the nutritional risk screening score and neutrophil-to-lymphocyte ratio(NLR;an index of inflammation)to provide a basis for the perioperative and nutritional management of patients with gynecologic malignancy.Methods:This study included 77 patients with gynecologic malignancies confirmed by surgical pathology between December 2021 and January 2023.Preoperative body composition data were obtained using bioelectrical impedance analysis.Nutritional risk screening and assessment were performed.Differences in body composition by age,nutritional status,International Federation of Gynecology and Obstetrics(FIGO)stage,systemic inflammatory response,and type of gynecologic malignancy were compared.Results:The extracellular water ratio was significantly higher in patients with a high FIGO stage than in those with a low FIGO stage(t=4.047,P<0.001).Other body composition parameters were lower in patients with a high FIGO stage than in those with a low FIGO stage(P<0.05).Regarding the NLR,the extracellular water ratio was significantly higher in patients with a high NLR than in those with a low NLR(t=2.929,P=0.005).As the nutritional condition worsened,the extracellular water ratio increased(H=12.291,P=0.002),with no significant difference in other body composition parameters between patients with different nutritional conditions(H=5.118,P=0.077).Other body composition parameters decreased with the nutritional condition,which was statistically significant(P<0.05).Conclusions:Bioelectrical impedance analysis is an easy-to-perform,noninvasive,and reproducible measurement technique that can assess changes in body composition.Body composition analysis can effectively determine an individual’s nutritional and metabolic status,providing a reference for the management of patients with gynecologic malignancy,and potentially providing predictive biomarkers to stratify these patients.展开更多
BACKGROUND Hepatobiliary and pancreatic malignancies,with their aggressiveness and poor prognosis,often trigger anxiety and depression in patients,but the roles of disease stage and psychosocial factors in this remain...BACKGROUND Hepatobiliary and pancreatic malignancies,with their aggressiveness and poor prognosis,often trigger anxiety and depression in patients,but the roles of disease stage and psychosocial factors in this remain unclear.AIM To explore the clinical characteristics and factors influencing comorbid anxiety and depression in patients with malignant liver,gallbladder,and pancreatic tumors.METHODS This study enrolled 150 participants,including 48 patients with early stage(IA-IB)hepatobiliary and pancreatic malignancies(Control Group 1),52 patients with middle-stage(IIA-IIIA)tumors(Observation Group),and 50 healthy individuals undergoing physical examination(Control Group 2).Anxiety and depression detection rates,and scores on the Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS),and Life Event Scale were compared across groups.The factors influencing emotion of each patient were collected and analyzed by group.RESULTS Anxiety and depression detection rates were significantly higher in the Observation Group(82.69%and 92.31%,respectively;P<0.05)than those in Control Groups 1(62.50%and 66.67%,respectively)and 2(10.00%and 8.00%,respectively).SAS and SDS scores showed similar trends.Life event stress scores and the presence of influencing factors,such as treatment side effects,pain,and economic burden,were also significantly elevated in the Observation Group.These findings suggest that psychological distress worsens as the disease progresses.CONCLUSION Patients with hepatobiliary and pancreatic malignancies are prone to comorbid anxiety and depression,with increasing severity in the later disease stages.Despite the relatively small sample size,our findings suggest the need for psychological assessments and interventions in comprehensive cancer care.Future studies should consider expanding the sample size to enhance generalizability.Strengthening psychosocial support may improve patient outcomes and quality of life.展开更多
Circular RNAs(circRNAs)are formed by splicing of precursor RNAs and covalently linked at the 5′and 3′ends.Dysregulated circRNAs are closely related to the epithelial-mesenchymal transition(EMT)of gastrointestinal ma...Circular RNAs(circRNAs)are formed by splicing of precursor RNAs and covalently linked at the 5′and 3′ends.Dysregulated circRNAs are closely related to the epithelial-mesenchymal transition(EMT)of gastrointestinal malignancies.CircRNAs,including circRNA_0008717,circGOT1,circ-DOCK5,circVPS33B,circPVT1,circMET,circ-OXCT1,circ_67835,circRTN4,circ_0087502,circFNDC38,circ_PTEN1,circPGPEP1,and circ-E-Cad are involved in the EMT process of gastrointestinal malignancies through a variety of mechanisms,such as regulating EMT-inducing transcription factors,signaling pathways,and tumor microenvironments.Gastrointestinal(GI)malignancies are common malignant tumors worldwide,and the heterogeneity and easy metastasis of gastrointestinal malignancies limit the effectiveness of medical treatments.Therefore,investigating the molecular mechanisms involved in the pathogenesis of gastrointestinal malignancies is essential for clinical treatment.This article summarizes the biological roles and molecular mechanism of circRNAs in EMT of gastrointestinal malignancies,providing a theoretical basis for applying EMT-related circRNAs in targeted therapy.展开更多
Background:Patients with hemato-oncological malignancies may respond insufficiently to vaccination,especially in terms of antibody titer.The antibody response depends on the type of malignancy as well as the type and ...Background:Patients with hemato-oncological malignancies may respond insufficiently to vaccination,especially in terms of antibody titer.The antibody response depends on the type of malignancy as well as the type and timing of treatment.We intended to evaluate this using real-world data from patients of our regional hospital.This study also considers the role of immune status,including T-cell activation markers,in predicting vaccination success.Methods:Seventeen patients of our hospital having a hematological malignancy were included in this study,including myeloma,lymphoma,as well as acute myeloid leukemia(AML)and chronic lymphoid leukemia(CLL).All patients were vaccinated against Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)using Tozinameran following current recommendations.Circulating antibodies directed against the spike protein of SARS-CoV-2 were determined by a commercial immune assay.Immune status was determined from peripheral blood by flow cytometry.Both parameters were followed in fifteen patients who provided sufficient follow-up data for up to one year.Patients were categorized as responders or non-responders,and differences in diagnosis,treatment,and immune status were analyzed.Results:Antibody response depended on both diagnosis and treatment.Active treatment directed against B-cells,such as anti-Cluster of Differentiation 20(CD20)therapy,was associated with weak seroconversion.For CD38-as well as proteasome-directed therapies,the data suggest that responders as well as non-responders exist.Notably,low peripheral B-cell numbers and high CD3+HLADR+cell counts correlated withweak seroconversion upon vaccination.Conclusions:We suggest that peripheral immune status can be applied as a predictive biomarker for seroconversion upon vaccinations.展开更多
Immuno-positron emission tomography(immuno-PET)is an innovative medical imaging technique that combines antibodies(Abs)or other immune-targeting molecules with positron-emitting radionuclides.By targeting antigens tha...Immuno-positron emission tomography(immuno-PET)is an innovative medical imaging technique that combines antibodies(Abs)or other immune-targeting molecules with positron-emitting radionuclides.By targeting antigens that are highly expressed in hematologic malignancies,immuno-PET has transformed diagnostic capabilities and enables precise monitoring of therapeutic responses through highly sensitive and specific tumor cell detection.Additionally,it plays a critical role in advancing therapeutic approaches by seamlessly linking diagnostic imaging with personalized treatment strategies.Its non-invasive nature and ability to provide whole-body imaging offer significant advantages over traditional diagnostic methods,especially for detecting minimal residual disease and guiding adaptive therapeutic interventions.In Ab-based immuno-PET,positronemitting radionuclides must have a half-life sufficient for slower pharmacokinetics and blood clearance of Abs.Recent studies have highlighted the advantages of long-lived radionuclides,such as 89Zr,which exhibit low positron energy and enable high sensitivity and resolution,making them particularly effective for tumor visualization and characterization.This review explores the current applications,recent advancements,and potential of immuno-PET for hematologic malignancies,emphasizing its pivotal role in improving patient outcomes and advancing precision medicine.展开更多
Objective To evaluate the clinical efficacy of Traditional Chinese Medicine(TCM)hot-pack therapy in treating postoperative gastrointestinal dysfunction in patients undergoing surgery for gastrointestinal malignancies....Objective To evaluate the clinical efficacy of Traditional Chinese Medicine(TCM)hot-pack therapy in treating postoperative gastrointestinal dysfunction in patients undergoing surgery for gastrointestinal malignancies.Method 60 postoperative patients with gastrointestinal malignancies were randomized into a treatment group(n=30)and a control group(n=30).Both groups received standard postoperative supportive care,including oral mosapride citrate(5 mg,three times daily,starting 6 h post-op,for 3 days).The treatment group additionally received external abdominal application of a TCM hot-pack twice daily(20-30 min each)for 3 days.Primary endpoints were time to first flatus,first defecation,and first oral intake.Secondary endpoints included numeric scores for abdominal pain and distension at 24 h and 72 h post-op,and overall clinical efficacy.Result Compared with controls,the treatment group showed significantly faster recovery:time to first flatus(50.3±7.8 h vs.62.5±9.4 h),first defecation(72.1±11.3 h vs.85.2±13.6 h),and first oral intake(48.0±9.5 h vs.62.5±12.4 h)(all P<0.01).At 24 h and 72 h,the treatment group reported lower abdominal pain and distension scores(24 h pain 5.1±1.3 vs.6.0±1.4,distension 2.3±0.5 vs.2.8±0.6;72 h pain 3.9±0.8 vs.4.7±0.9,distension 1.9±0.5 vs.2.3±0.6;P<0.05 to P<0.01).Total effective rate was higher in the treatment group(96.7%vs.90.0%,χ^(2)=6.96,P=0.031).Conclusion TCM hot-pack therapy combined with routine care significantly accelerates recovery of gastrointestinal function,shortens duration of postoperative dysfunction,and alleviates abdominal pain and distension in patients after gastrointestinal malignancy surgery,demonstrating notable clinical benefit.展开更多
With the advances in allogeneic hematopoietic cell transplantation(allo-HCT)and supportive care,the number of allo-HCT for elderly patients has been increasing in recent years.However,the advanced donor age limits the...With the advances in allogeneic hematopoietic cell transplantation(allo-HCT)and supportive care,the number of allo-HCT for elderly patients has been increasing in recent years.However,the advanced donor age limits the availability of human leukocyte antigen(HLA)-matched sibling donors(MSD)for elderly individuals.展开更多
Since 1968 when the first successful hematopoietic stem cell transplantation(HSCT) was performed, transplant technique has developed rapidly for more than 50 years. In the past 20 years, the significant breakthroughs ...Since 1968 when the first successful hematopoietic stem cell transplantation(HSCT) was performed, transplant technique has developed rapidly for more than 50 years. In the past 20 years, the significant breakthroughs and widely use of haploidentical-related donor HSCT(e.g. Beijing Protocol) make everyone can have a donor(1), and the novel, reduced-toxicity transplant regimens help elderly patients receive HSCT safely(2).展开更多
基金Student Innovation Capability Enhancement Program of Guangzhou Medical University,Grant/Award Numbers:2022 NO.67,2023 NO.7Special Funds for the Cultivation of Guangdong College Students'Scientific and Technological Innovation(“Climbing Program”Special Funds),Grant/Award Number:pdjh2023b0431。
文摘Background:Prostate cancer(PCa)patients are at risk of developing second primary malignancies(SPMs),which can significantly shorten their survival.Understanding the risk of SPMs and associated factors is crucial to the optimization of patient follow-up.Methods:This study focuses on PCa patients who were later diagnosed with SPMs using data from the Surveillance,Epidemiology,and End Results(SEER)database.Variables were carefully selected,and the data were analyzed using machine learning techniques combined with mul-tivariate Cox proportional hazards modeling.Subsequently,a nomogram was generated to predict the 1-,3-,and 5-year survival rates for SPMs patients.Additionally,a two-sample Mendelian randomization(TSMR)analysis was conducted to investigate the causal relationships between PCa and its top ten SPMs.Results:Among the variables,age,marital status,SPM site,M stage,American Joint Committee on Cancer(AJCC)stage,PCa surgery,and prostate-specific antigen(PSA)levels were identified as key prognostic factors through least absolute shrinkage and selection operator(LASSO)and backward stepwise regression.Based on these factors,a nomogram was developed to visually represent survival predictions,complemented by a web-based calculator for easy application.This nomogram,which serves as a supplement to traditional AJCC staging,demonstrated strong predictive power for 1-,3-,and 5-year survival,with area under the curve(AUC)values exceeding 0.85.Additionally,TSMR analysis revealed a causal link between PCa and urothelial carcinoma(UC).Conclusion:This study developed a nomogram for predicting survival in prostate cancer patients with secondary primary malignancies,enhancing prognosis accuracy.TSMR identified a causal link between PCa and UC.
文摘BACKGROUND Resilience is an individual’s ability and psychological rebound capacity to adapt well after experiencing adversity,trauma,etc.Patients with strong resilience can face illnesses actively.AIM To determine the association of resilience with coping styles and quality of life in patients with malignancies.METHODS This study included patients with malignant tumors who were hospitalized at Fuyang Hospital Affiliated to Anhui Medical University from March 2022 to March 2024.The Connor-Davidson Resilience Scale,Medical Coping Modes Questionnaire,Social Support Rating Scale,and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 were utilized to assess patients’resilience,coping styles,social support,and quality of life,respectively.Pearson correlation analysis was conducted to assess the correlations.RESULTS A total of 175 patients with malignant tumors demonstrated no marked difference in terms of age,education level,employment status,monthly household income,and disease staging(P<0.05).Further,patients with malignancies demonstrated scores of 17.49±1.20,17.27±1.46,and 11.19±1.29 points in terms of coping styles in confrontation,avoidance,and resignation dimensions,respectively.Subjective support,objective support,and support utilization scores in terms of social support were 10.67±1.80,11.26±2.08,and 9.24±1.14 points,respectively.The total resilience score and tenacity,self-improvement,and optimism dimension scores were positively correlatedwith the confrontation coping style score,whereas the total resilience score and tenacity and self-improvementscores were negatively associated with avoidance and resignation coping style scores(P<0.05).The total resiliencescore and the tenacity dimension score were positively associated with physical,role,cognitive,emotional,andsocial functions,as well as global health status(P<0.05),and were inversely related to fatigue,insomnia,andeconomic difficulties(P<0.05).CONCLUSIONThe resilience of patients with malignancies is positively associated with the confrontation dimension in the copingstyle,the total and various social support domain scores,and the overall quality of life.Clinical medical staff needto pay attention to the effect of medical coping styles and social support on the resilience level of patients withmalignancies to further improve their quality of life.
文摘Liver transplantation(LT)is the definitive treatment for end-stage liver disease,acute liver failure,and liver cancer.Although advancements in surgical techniques,postoperative care,and immunosuppressive therapies have significantly improved outcomes,the long-term use of immunosuppression has increased the risk of complications,including infections,cardiovascular disease,and cancer.Among these,de novo malignancies(DNMs)are a major concern,accounting for 20%-25%of deaths in LT recipients surviving beyond the early post-transplant period.Non-melanoma skin cancers,particularly squamous cell carcinoma are the most prevalent DNMs.Other significant malignancies include Kaposi's sarcoma,post-transplant lymphoproliferative disorders,and various solid organ cancers,including head and neck cancers.Compared to the general population,LT patients face a twofold increase in solid organ malignancies and a 30-fold increase in lymphoproliferative disorders.Risk factors for DNM include chronic immunosuppression,alcohol or tobacco use,viral infections,and underlying liver disease.Emerging evidence emphasizes the importance of tailored cancer screening and prevention strategies,including regular dermatological examinations,targeted screenings for high-risk cancers,and patient education on lifestyle modifications.Early detection through enhanced surveillance protocols has been shown to improve outcomes.Management of DNMs involves a combination of standard oncological therapies and adjustments to immunosuppressive regimens,with promising results from the use of mTOR inhibitors in select patients.The review highlights the critical need for ongoing research to refine risk stratification,optimize screening protocols,and improve treatment approaches to mitigate the burden of DNMs in LT recipients.By implementing personalized preventive and therapeutic strategies,we can enhance long-term outcomes and quality of life for this vulnerable population.
基金Supported by the 2023 Government-funded Project of the Outstanding Talents Training Program in Clinical Medicine,No.ZF2023165Key Research and Development Projects of Hebei Province,No.18277731D+1 种基金Natural Science Foundation of Hebei Province,No.H202423105Hebei Provincial Administration of Traditional Chinese Medicine,Scientific Research Project,No.2020014.
文摘In this editorial,we comment on the article by Qin et al,recently published in the World Journal of Gastrointestinal Oncology.Malignant tumors of the digestive tract represent a significant health threat.Kinesin family member 14(KIF14),a critical kinesin,is pivotal in the proliferation,migration,and invasion of tumor cells.It has emerged as a focal point in recent studies of malignant tumors in the digestive tract.This article reviews the current research on KIF14 within these tumors and details its significant role in tumor cell behaviors,including proliferation,apo-ptosis,migration,invasion,and angiogenesis,alongside the regulatory mechanisms of the associated intracellular signaling pathways.Additionally,it explores the clinical value of KIF14 as a potential biomarker for early diagnosis,disease monitoring,and prognostic evaluation in malignant tumors of the digestive tract.The article concludes by introducing the potential regulatory role of traditional Chinese medicine,aiming to combine the strengths of both modern and traditional medical approaches to enhance treatment outcomes and prognosis for patients with these tumors.
基金supported by grants from the National Natural Science Foundation of China(No.81920108004,82270127,82203880)the Hunan Provincial Natural Science Foundation of China(No.2023JJ30928,2024JJ3037)+2 种基金the Changsha Municipal Natural Sci-Science Foundation(No.kq2208382)the Fellowship of the China Postdoctoral Science Foundation(No.2023T160740)the Hunan Province Clinical Medical Technology Innovation Guidance Project(No.2021SK50917,2023SK4056)。
文摘Hematologic malignancies,including leukemia,lymphoma,and multiple myeloma,are hazardous diseases characterized by the uncontrolled proliferation of cancer cells.Dysregulated cell cycle resulting from genetic and epigenetic abnormalities constitutes one of the central events.Importantly,cyclin-dependent kinases(CDKs),complexed with their functional partner cyclins,play dominating roles in cell cycle control.Yet,efforts in translating CDK inhibitors into clinical benefits have demonstrated disappointing outcomes.Recently,mounting evidence highlights the emerging significance of WEE1 G2 checkpoint kinase(WEE1)to modulate CDK activity,and correspondingly,a variety of therapeutic inhibitors have been developed to achieve clinical benefits.Thus,WEE1 may become a promising target to modulate the abnormal cell cycle.However,its function in hematologic diseases remains poorly elucidated.In this review,focusing on hematologic malignancies,we describe the biological structure of WEE1,emphasize the latest reported function of WEE1 in the carcinogenesis,progression,as well as prognosis,and finally summarize the therapeutic strategies by targeting WEE1.
基金supported by the National Natural Science Foundation of China(82101069)the Beijing Natural Science Foundation(7242279),the Beijing Nova Program(20230484283)+2 种基金the Beijing Municipal Science&Technology Commission(Z221100007422130)the Open Project of State Key Laboratory of Trauma and Chemical Poisoning(SKLO202401)the Logistics Independent Research Project of PLA(C24LBJ032).
文摘Background:Second primary malignancies(SPMs)account for over 30%of total deaths in head and neck cancer(HNC)patients.The increasing use of radiotherapy raises concerns about the elevated risk of radiation-associated SPMs.This study aimed to investigate the age-stratified association between radiotherapy and SPM risk in survivors of non-metastatic primary HNC.Methods:Using data from the Surveillance,Epidemiology,and End Results program(2004-2015),incidence rate ratios(IRRs)and standardized incidence ratios(SIRs)were evaluated for solid and hematologic SPMs associated with radiotherapy within different age groups.Follow-up for hematologic and solid SPMs began 2 and 5 years,respectively,after the diagnosis of first primary HNC.The IRRs for SPMs were compared between radiotherapy-exposed and unexposed groups using multivariable modified Poisson regression.The SIRs were computed as the ratio of observed cancers in the cohort to expected cases derived from sex-,age-,and calendar year-matched general population incidence rates.Results:The study included 75,2092-year survivors,with 73.2%being male and a median age of 60 years.Of these,58,063 had survived 5 years or more.Radiotherapy was associated with an increased risk of solid SPMs[IRR=1.16,95%confidence interval(CI)1.08-1.24;P<0.001].The associations varied significantly among young(aged 15-39 years),middle-aged(aged 40-64 years),and elderly(aged 65-89 years)patients.Specifically,radiotherapy was associated with an increased risk of solid SPMs in middle-aged patients(IRR=1.21,95%CI 1.11-1.32;P<0.001),and a decreased risk of hematologic SPMs in elderly patients(IRR=0.77,95%CI 0.60-0.99;P=0.045).Compared with the general population,young patients had an elevated risk of radiotherapy-associated second primary non-Hodgkin lymphoma(SIR=4.01,95%CI 1.47-8.74).Middle-aged patients showed the highest SIR for SPMs in the bones/joints(SIR=7.72,95%CI 4.32-12.73),while elderly patients had the highest SIR for second primary esophageal malignancies(SIR=3.87,95%CI 2.91-5.05).Males were more likely to develop solid SPMs compared to females.Conclusions:This study reveals an age-stratified association between radiotherapy and the risk of SPMs in HNC patients.These findings highlight the importance of considering patient age when making treatment decisions for HNC and suggest that long-term surveillance is necessary for high-risk groups.
文摘BACKGROUND Cytoreductive surgery(CRS)combined with hyperthermic intraperitoneal chemotherapy(HIPEC)has become an established treatment for selected patients with peritoneal metastases(PM)from colorectal,ovarian,and gastric cancers,as well as for certain primary peritoneal tumors such as pseudomyxoma peritonei.However,evidence supporting its role in other uncommon indications remains limited,largely due to the rarity and heterogeneity of these malignancies and the absence of standardized treatment protocols.Understanding the potential survival benefit and safety profile of CRS+HIPEC in these contexts may help refine patient selection and guide clinical decision-making.AIM To evaluate surgical and oncologic outcomes,particularly overall survival(OS),in this heterogeneous patient population and assess perioperative morbidity and mortality to better define the safety profile of this aggressive multimodal strategy.METHODS We retrospectively reviewed data from five tertiary cancer centers on patients who underwent CRS+HIPEC between January 2004 and December 2021 for PM from uncommon histologies,defined as any primary tumor other than colorectal,gastric,or ovarian carcinomas,pseudomyxoma peritonei,or malignant peritoneal mesothelioma.Baseline characteristics,operative details,complications(graded by the Clavien-Dindo classification),and survival outcomes were analyzed.OS was estimated using Kaplan-Meier analysis.Prognostic factors were evaluated using univariate and multivariate Cox proportional hazards models.The discriminatory ability and overall fit of the final model were assessed by the concordance index(C-index)and likelihood ratio test,respectively.RESULTS A total of 60 CRS+HIPEC procedures were performed in 60 patients(mean age=58.5 years,78.3%female).The most frequent primary tumors were uterine(35%)and breast cancer(20%).Median operative time was 405 minutes,and 75%of patients required perioperative transfusions.Major complications(Clavien-Dindo≥3)occurred in 21.6%of patients,and 90-day mortality was 1.6%.Median OS for the entire cohort was 28 months.Kaplan-Meier analysis showed that breast cancer patients achieved the longest survival(median OS=75 months)compared with uterine cancer(32 months)and other primaries(17 months).Multivariate analysis confirmed tumor origin as the strongest independent predictor of OS(C-index=0.81;likelihood ratio test=40.07;P<0.001).CONCLUSION Our findings suggest that CRS+HIPEC can be performed safely in highly selected patients with PM from uncommon primary tumors,achieving meaningful long-term survival in subsets such as breast and uterine cancers.Tumor biology,rather than clinical factors,emerged as the key determinant of survival.Given the rarity and heterogeneity of these malignancies,collaborative multicenter efforts and prospective registries are essential to establish standardized selection criteria and optimize outcomes.
文摘Objective:To explore the epidemiological trends and clinical presentations of brucellosis in patients diagnosed with different types of cancer.Methods:A systematic review was performed utilizing PubMed,Embase,Scopus,Web of Science,and Google Scholar following PRISMA guidelines until September 2022.An update in December 2023 was conducted to ensure thorough coverage of the literature.Results:A total of 28 articles met the eligibility criteria,reporting 38 cases of brucellosis in patients with cancer.Among these cases,hematological cancers were the most common,comprising 66%of the cases,and B.melitensis was identified as the predominant species.The primary clinical manifestations of brucellosis infection included constitutional symptoms in a notable 60.5%of cases and febrile neutropenia in 21%.Additionally,six cases(15.8%)experienced relapse or recurrence of brucellosis,all of which were managed using a combination therapy of rifampin and doxycycline.While 28 patients successfully achieved remission from both brucellosis and their underlying neoplastic conditions,unfortunately,nine cases resulted in mortality attributed to septic shock,progressive liver failure,and massive embolism;no deaths directly related to brucellosis were reported.Among the non-surviving cases,hematologic malignancies were the most prevalent neoplastic conditions(77.7%).Conclusions:Brucellosis-cancer co-occurrence is rare but is not related to increasing mortality.The risk of relapse is higher in cancer patients,especially with hematologic malignancies.Screening,monitoring,and judicious antibiotic use can mitigate brucellosis risks in neoplastic patients.
基金funded by the Jiangsu Graduate Student Practice and Innovation Program(No.SJCX23_0665).
文摘Objective:To analyze body composition measurements and explore their correlation with the nutritional risk screening score and neutrophil-to-lymphocyte ratio(NLR;an index of inflammation)to provide a basis for the perioperative and nutritional management of patients with gynecologic malignancy.Methods:This study included 77 patients with gynecologic malignancies confirmed by surgical pathology between December 2021 and January 2023.Preoperative body composition data were obtained using bioelectrical impedance analysis.Nutritional risk screening and assessment were performed.Differences in body composition by age,nutritional status,International Federation of Gynecology and Obstetrics(FIGO)stage,systemic inflammatory response,and type of gynecologic malignancy were compared.Results:The extracellular water ratio was significantly higher in patients with a high FIGO stage than in those with a low FIGO stage(t=4.047,P<0.001).Other body composition parameters were lower in patients with a high FIGO stage than in those with a low FIGO stage(P<0.05).Regarding the NLR,the extracellular water ratio was significantly higher in patients with a high NLR than in those with a low NLR(t=2.929,P=0.005).As the nutritional condition worsened,the extracellular water ratio increased(H=12.291,P=0.002),with no significant difference in other body composition parameters between patients with different nutritional conditions(H=5.118,P=0.077).Other body composition parameters decreased with the nutritional condition,which was statistically significant(P<0.05).Conclusions:Bioelectrical impedance analysis is an easy-to-perform,noninvasive,and reproducible measurement technique that can assess changes in body composition.Body composition analysis can effectively determine an individual’s nutritional and metabolic status,providing a reference for the management of patients with gynecologic malignancy,and potentially providing predictive biomarkers to stratify these patients.
文摘BACKGROUND Hepatobiliary and pancreatic malignancies,with their aggressiveness and poor prognosis,often trigger anxiety and depression in patients,but the roles of disease stage and psychosocial factors in this remain unclear.AIM To explore the clinical characteristics and factors influencing comorbid anxiety and depression in patients with malignant liver,gallbladder,and pancreatic tumors.METHODS This study enrolled 150 participants,including 48 patients with early stage(IA-IB)hepatobiliary and pancreatic malignancies(Control Group 1),52 patients with middle-stage(IIA-IIIA)tumors(Observation Group),and 50 healthy individuals undergoing physical examination(Control Group 2).Anxiety and depression detection rates,and scores on the Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS),and Life Event Scale were compared across groups.The factors influencing emotion of each patient were collected and analyzed by group.RESULTS Anxiety and depression detection rates were significantly higher in the Observation Group(82.69%and 92.31%,respectively;P<0.05)than those in Control Groups 1(62.50%and 66.67%,respectively)and 2(10.00%and 8.00%,respectively).SAS and SDS scores showed similar trends.Life event stress scores and the presence of influencing factors,such as treatment side effects,pain,and economic burden,were also significantly elevated in the Observation Group.These findings suggest that psychological distress worsens as the disease progresses.CONCLUSION Patients with hepatobiliary and pancreatic malignancies are prone to comorbid anxiety and depression,with increasing severity in the later disease stages.Despite the relatively small sample size,our findings suggest the need for psychological assessments and interventions in comprehensive cancer care.Future studies should consider expanding the sample size to enhance generalizability.Strengthening psychosocial support may improve patient outcomes and quality of life.
基金supported by grants from the Key Scientific and Technological Projects of Ningbo(No.2021Z133)Ningbo Top Medical and Health Research Program(No.2023020612)+2 种基金National Natural Science Foundation of China(No.81702367)the Medical and Health Research Project of Zhejiang Province(No.2024KY319)the Youth Medical Backbone Talents Training Program of Ningbo.
文摘Circular RNAs(circRNAs)are formed by splicing of precursor RNAs and covalently linked at the 5′and 3′ends.Dysregulated circRNAs are closely related to the epithelial-mesenchymal transition(EMT)of gastrointestinal malignancies.CircRNAs,including circRNA_0008717,circGOT1,circ-DOCK5,circVPS33B,circPVT1,circMET,circ-OXCT1,circ_67835,circRTN4,circ_0087502,circFNDC38,circ_PTEN1,circPGPEP1,and circ-E-Cad are involved in the EMT process of gastrointestinal malignancies through a variety of mechanisms,such as regulating EMT-inducing transcription factors,signaling pathways,and tumor microenvironments.Gastrointestinal(GI)malignancies are common malignant tumors worldwide,and the heterogeneity and easy metastasis of gastrointestinal malignancies limit the effectiveness of medical treatments.Therefore,investigating the molecular mechanisms involved in the pathogenesis of gastrointestinal malignancies is essential for clinical treatment.This article summarizes the biological roles and molecular mechanism of circRNAs in EMT of gastrointestinal malignancies,providing a theoretical basis for applying EMT-related circRNAs in targeted therapy.
基金supported by a grant of the Deutsche Forschungsgemeinschaft(DFG)to G.B.(#405833349).
文摘Background:Patients with hemato-oncological malignancies may respond insufficiently to vaccination,especially in terms of antibody titer.The antibody response depends on the type of malignancy as well as the type and timing of treatment.We intended to evaluate this using real-world data from patients of our regional hospital.This study also considers the role of immune status,including T-cell activation markers,in predicting vaccination success.Methods:Seventeen patients of our hospital having a hematological malignancy were included in this study,including myeloma,lymphoma,as well as acute myeloid leukemia(AML)and chronic lymphoid leukemia(CLL).All patients were vaccinated against Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)using Tozinameran following current recommendations.Circulating antibodies directed against the spike protein of SARS-CoV-2 were determined by a commercial immune assay.Immune status was determined from peripheral blood by flow cytometry.Both parameters were followed in fifteen patients who provided sufficient follow-up data for up to one year.Patients were categorized as responders or non-responders,and differences in diagnosis,treatment,and immune status were analyzed.Results:Antibody response depended on both diagnosis and treatment.Active treatment directed against B-cells,such as anti-Cluster of Differentiation 20(CD20)therapy,was associated with weak seroconversion.For CD38-as well as proteasome-directed therapies,the data suggest that responders as well as non-responders exist.Notably,low peripheral B-cell numbers and high CD3+HLADR+cell counts correlated withweak seroconversion upon vaccination.Conclusions:We suggest that peripheral immune status can be applied as a predictive biomarker for seroconversion upon vaccinations.
文摘Immuno-positron emission tomography(immuno-PET)is an innovative medical imaging technique that combines antibodies(Abs)or other immune-targeting molecules with positron-emitting radionuclides.By targeting antigens that are highly expressed in hematologic malignancies,immuno-PET has transformed diagnostic capabilities and enables precise monitoring of therapeutic responses through highly sensitive and specific tumor cell detection.Additionally,it plays a critical role in advancing therapeutic approaches by seamlessly linking diagnostic imaging with personalized treatment strategies.Its non-invasive nature and ability to provide whole-body imaging offer significant advantages over traditional diagnostic methods,especially for detecting minimal residual disease and guiding adaptive therapeutic interventions.In Ab-based immuno-PET,positronemitting radionuclides must have a half-life sufficient for slower pharmacokinetics and blood clearance of Abs.Recent studies have highlighted the advantages of long-lived radionuclides,such as 89Zr,which exhibit low positron energy and enable high sensitivity and resolution,making them particularly effective for tumor visualization and characterization.This review explores the current applications,recent advancements,and potential of immuno-PET for hematologic malignancies,emphasizing its pivotal role in improving patient outcomes and advancing precision medicine.
基金2024 Technological Innovation Project of Shapingba District,Chongqing(2024174)。
文摘Objective To evaluate the clinical efficacy of Traditional Chinese Medicine(TCM)hot-pack therapy in treating postoperative gastrointestinal dysfunction in patients undergoing surgery for gastrointestinal malignancies.Method 60 postoperative patients with gastrointestinal malignancies were randomized into a treatment group(n=30)and a control group(n=30).Both groups received standard postoperative supportive care,including oral mosapride citrate(5 mg,three times daily,starting 6 h post-op,for 3 days).The treatment group additionally received external abdominal application of a TCM hot-pack twice daily(20-30 min each)for 3 days.Primary endpoints were time to first flatus,first defecation,and first oral intake.Secondary endpoints included numeric scores for abdominal pain and distension at 24 h and 72 h post-op,and overall clinical efficacy.Result Compared with controls,the treatment group showed significantly faster recovery:time to first flatus(50.3±7.8 h vs.62.5±9.4 h),first defecation(72.1±11.3 h vs.85.2±13.6 h),and first oral intake(48.0±9.5 h vs.62.5±12.4 h)(all P<0.01).At 24 h and 72 h,the treatment group reported lower abdominal pain and distension scores(24 h pain 5.1±1.3 vs.6.0±1.4,distension 2.3±0.5 vs.2.8±0.6;72 h pain 3.9±0.8 vs.4.7±0.9,distension 1.9±0.5 vs.2.3±0.6;P<0.05 to P<0.01).Total effective rate was higher in the treatment group(96.7%vs.90.0%,χ^(2)=6.96,P=0.031).Conclusion TCM hot-pack therapy combined with routine care significantly accelerates recovery of gastrointestinal function,shortens duration of postoperative dysfunction,and alleviates abdominal pain and distension in patients after gastrointestinal malignancy surgery,demonstrating notable clinical benefit.
基金supported by National Natural Science Foundation of China(No.82370215,82020108003,and 82330008)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),Jiangsu Provincial Medical Innovation Center(No.CXZX202201)Science and Technology Program of Suzhou(No.SKY2023047)。
文摘With the advances in allogeneic hematopoietic cell transplantation(allo-HCT)and supportive care,the number of allo-HCT for elderly patients has been increasing in recent years.However,the advanced donor age limits the availability of human leukocyte antigen(HLA)-matched sibling donors(MSD)for elderly individuals.
文摘Since 1968 when the first successful hematopoietic stem cell transplantation(HSCT) was performed, transplant technique has developed rapidly for more than 50 years. In the past 20 years, the significant breakthroughs and widely use of haploidentical-related donor HSCT(e.g. Beijing Protocol) make everyone can have a donor(1), and the novel, reduced-toxicity transplant regimens help elderly patients receive HSCT safely(2).
