Diabetes mellitus has emerged as a widespread global health concern,contributing significantly to morbidity and mortality rates.The metabolic disturbances associated with diabetes can adversely impact the male reprodu...Diabetes mellitus has emerged as a widespread global health concern,contributing significantly to morbidity and mortality rates.The metabolic disturbances associated with diabetes can adversely impact the male reproductive system,leading to reduced fertility.This review offers an in-depth evaluation of recent global research exploring the impact of diabetes on male reproductive health.Relevant experimental and clinical studies were identified,with a focus on diabetes-related effects on reproductive organs,hormones,and sexual function.The review highlights that insulin deficiency and resistance in diabetic conditions disrupt the hypothalamic-pituitary-gonadal axis,reducing levels of key reproductive hormones such as gonadotropin releasing hormone,luteinizing hormone,follicle stimulating hormone,and testosterone.These hormonal disruptions lead to structural and functional damage in reproductive organs including the testes,Sertoli cells,epididymis,sperm,and accessory glands.Moreover,diabetes contributes to erectile and ejaculatory dysfunctions.Various pathophysiological mechanisms such as oxidative stress,hormonal imbalances,germ cell apoptosis,autophagy,mitochondrial dysfunction,and endoplasmic reticulum stress are identified as underlying contributors to diabetes-induced male infertility.The findings of this review provide valuable insights into the complex mechanisms by which diabetes affects the male reproductive function.By integrating current research,it highlights the critical need for further studies and the development of targeted therapies to effectively address diabetes-induced infertility.展开更多
Background:The male reproductive system consists of the testes,epididymis,accessory gonads,and genital ducts.The physiological integrity of the testicles is essential for successful sperm production,but the testes are...Background:The male reproductive system consists of the testes,epididymis,accessory gonads,and genital ducts.The physiological integrity of the testicles is essential for successful sperm production,but the testes are susceptible to a variety of exogenous and endogenous toxins,which can lead to structural damage to tissues and sperm abnormalities.Spermatogenesis is always in a homeostatic process and is sensitive to changes in the external environment.Huperzia serrata flavonoids(HSF)have a variety of pharmacological effects,including the treatment of bruises,strains,etc.HSF can improve the reproductive function of male mice,so the purpose of this experiment is to explore whether huperzine flavonoids are involved in and regulate the male reproductive process.Methods:Our experimental animals were ICR mice,and samples were collected after 28 days of HSF treatment,and verified by a series of experimental methods such as immunofluorescence,immunohistochemistry,HE staining,protein hybridization,and screening of related genes.Results:RNA sequencing results showed that HSF up-regulated genes related to sperm development and differentiation in testes and promoted spermatogenesis.HSF is effective in promoting steroid hormone synthesis by modulating STAR,CYP11A1,and CYP17A1.Conclusion:Thus,HSF can regulate testicular gene expression,stabilize the gut microbiome,alter serum metabolites,and regulate steroid homeostasis.展开更多
Background： Soybean isoflavones are structurally similar to mammalian estrogens and therefore may act as estrogen agonists or antagonists. However, it has not been determined if they have any negative effects on repr...Background： Soybean isoflavones are structurally similar to mammalian estrogens and therefore may act as estrogen agonists or antagonists. However, it has not been determined if they have any negative effects on reproductive parameters in male livestock. Therefore, the objective of this study was to evaluate the effects of soybean isofiavones on male reproduction using Chinese mini-pig boars as a model. Fifty Xiang boars were randomly divided into five groups and fed diets containing 0, 125, 250, or 500 ppm soybean isoflavones or 0.5 ppm diethylstilbestrol for 60 days. Results： Dietary supplementation with 250 ppm of soy isoflavones markedly increased the testis index （P 〈 0.05）, fructose content （P 〈 0.05）, and o-glycosidase content in testicular tissue （P 〈 0.01）, as well as increased the number of viable germ cells （P 〈 0.01） and the level of Bcl-2 protein （P 〈 0.01）. However, 500 ppm of soybean isoflavones significantly reduced both testis and epididymis indexes （P 〈 0.0S） and lactate dehydrogenase levels （P 〈 0.01）, as well as reduced serum LH and testosterone levels （P 〈 0.05）. High levels of soybean isoflavones also increased malondialdehyde levels （P 〈 0.05）, as well as increased the numbers of early and late apoptotic germ cells （P 〈 0.01） and the level of Bax proteins （P 〈 0.05） in the testis. Conclusions： The results of this study indicate that consumption of soy isoflavones at dietary levels up to 250 ppm did not adversely affect reproductive parameters in Chinese mini-pig boars whereas higher levels of soy isoflavones may adversely affect male reproduction.展开更多
文摘Diabetes mellitus has emerged as a widespread global health concern,contributing significantly to morbidity and mortality rates.The metabolic disturbances associated with diabetes can adversely impact the male reproductive system,leading to reduced fertility.This review offers an in-depth evaluation of recent global research exploring the impact of diabetes on male reproductive health.Relevant experimental and clinical studies were identified,with a focus on diabetes-related effects on reproductive organs,hormones,and sexual function.The review highlights that insulin deficiency and resistance in diabetic conditions disrupt the hypothalamic-pituitary-gonadal axis,reducing levels of key reproductive hormones such as gonadotropin releasing hormone,luteinizing hormone,follicle stimulating hormone,and testosterone.These hormonal disruptions lead to structural and functional damage in reproductive organs including the testes,Sertoli cells,epididymis,sperm,and accessory glands.Moreover,diabetes contributes to erectile and ejaculatory dysfunctions.Various pathophysiological mechanisms such as oxidative stress,hormonal imbalances,germ cell apoptosis,autophagy,mitochondrial dysfunction,and endoplasmic reticulum stress are identified as underlying contributors to diabetes-induced male infertility.The findings of this review provide valuable insights into the complex mechanisms by which diabetes affects the male reproductive function.By integrating current research,it highlights the critical need for further studies and the development of targeted therapies to effectively address diabetes-induced infertility.
基金supported by a high-level talent research fund project of Qingdao Agricultural University in China(1120043).
文摘Background:The male reproductive system consists of the testes,epididymis,accessory gonads,and genital ducts.The physiological integrity of the testicles is essential for successful sperm production,but the testes are susceptible to a variety of exogenous and endogenous toxins,which can lead to structural damage to tissues and sperm abnormalities.Spermatogenesis is always in a homeostatic process and is sensitive to changes in the external environment.Huperzia serrata flavonoids(HSF)have a variety of pharmacological effects,including the treatment of bruises,strains,etc.HSF can improve the reproductive function of male mice,so the purpose of this experiment is to explore whether huperzine flavonoids are involved in and regulate the male reproductive process.Methods:Our experimental animals were ICR mice,and samples were collected after 28 days of HSF treatment,and verified by a series of experimental methods such as immunofluorescence,immunohistochemistry,HE staining,protein hybridization,and screening of related genes.Results:RNA sequencing results showed that HSF up-regulated genes related to sperm development and differentiation in testes and promoted spermatogenesis.HSF is effective in promoting steroid hormone synthesis by modulating STAR,CYP11A1,and CYP17A1.Conclusion:Thus,HSF can regulate testicular gene expression,stabilize the gut microbiome,alter serum metabolites,and regulate steroid homeostasis.
文摘Background： Soybean isoflavones are structurally similar to mammalian estrogens and therefore may act as estrogen agonists or antagonists. However, it has not been determined if they have any negative effects on reproductive parameters in male livestock. Therefore, the objective of this study was to evaluate the effects of soybean isofiavones on male reproduction using Chinese mini-pig boars as a model. Fifty Xiang boars were randomly divided into five groups and fed diets containing 0, 125, 250, or 500 ppm soybean isoflavones or 0.5 ppm diethylstilbestrol for 60 days. Results： Dietary supplementation with 250 ppm of soy isoflavones markedly increased the testis index （P 〈 0.05）, fructose content （P 〈 0.05）, and o-glycosidase content in testicular tissue （P 〈 0.01）, as well as increased the number of viable germ cells （P 〈 0.01） and the level of Bcl-2 protein （P 〈 0.01）. However, 500 ppm of soybean isoflavones significantly reduced both testis and epididymis indexes （P 〈 0.0S） and lactate dehydrogenase levels （P 〈 0.01）, as well as reduced serum LH and testosterone levels （P 〈 0.05）. High levels of soybean isoflavones also increased malondialdehyde levels （P 〈 0.05）, as well as increased the numbers of early and late apoptotic germ cells （P 〈 0.01） and the level of Bax proteins （P 〈 0.05） in the testis. Conclusions： The results of this study indicate that consumption of soy isoflavones at dietary levels up to 250 ppm did not adversely affect reproductive parameters in Chinese mini-pig boars whereas higher levels of soy isoflavones may adversely affect male reproduction.
