Olfactory ensheathing cells （OECs） can promote axonal regeneration and remyelination for the treatment of spinal cord injury. OECs can also treat experimental allergic encephalomyelitis （EAE）, but it remains uncle...Olfactory ensheathing cells （OECs） can promote axonal regeneration and remyelination for the treatment of spinal cord injury. OECs can also treat experimental allergic encephalomyelitis （EAE）, but it remains unclear whether OECs might be rejected by the immune system in the brain including the destruction of the blood-brain barrier under inflammation, the release of inflammatory factors, the activation of local antigen-presenting cells （e.g., microglia cells） and antigen drainage. We found that OECs expressed major histocompatibility complex （MHC）-I molecules on the cell surface, barely expressed MHC-II, but MHC-II could be induced by interferon-v, suggesting that OECs have certain immunogenicity. When OECs were transplanted into normal animal brains, no OECs were phagocytosed by dendritic cells in the cervical lymph node, and OECs did not induce lymphocyte proliferation, which indicates that OECs share some immune privilege under normal conditions. However, OECs in the rat EAE brain were phagocytosed by dendritic cells in the cervical lymph node and enhanced lymphocyte proliferation. These findings suggest that OECs are rejected because of increased immunogenicity in EAE brain, and that brain inflammation, in particular activated dendritic cells, may be a prerequisite for rejecting OECs.展开更多
以OBE(Outcome Based Education)教育理念为核心,针对传统课程在教学模式、实践机会、设备与项目以及师资等方面存在的问题,提出了一种基于OBE理念的机电类实验课程改革方案,构建了WHHM实施框架,并以此搭建新工科视域下包含基础层、专...以OBE(Outcome Based Education)教育理念为核心,针对传统课程在教学模式、实践机会、设备与项目以及师资等方面存在的问题,提出了一种基于OBE理念的机电类实验课程改革方案,构建了WHHM实施框架,并以此搭建新工科视域下包含基础层、专业层、综合层和创新层的四层实验课程体系。结合地方产业需求的情境化实验教学实例设计过程,阐述其具体实践过程,提出加强校地交流、建立多渠道反馈机制、基于反馈持续改进教学等建议。展开更多
基金Young Talent Innovation Program of Fujian Province Department of Science and Technology,No.2006F3032
文摘Olfactory ensheathing cells （OECs） can promote axonal regeneration and remyelination for the treatment of spinal cord injury. OECs can also treat experimental allergic encephalomyelitis （EAE）, but it remains unclear whether OECs might be rejected by the immune system in the brain including the destruction of the blood-brain barrier under inflammation, the release of inflammatory factors, the activation of local antigen-presenting cells （e.g., microglia cells） and antigen drainage. We found that OECs expressed major histocompatibility complex （MHC）-I molecules on the cell surface, barely expressed MHC-II, but MHC-II could be induced by interferon-v, suggesting that OECs have certain immunogenicity. When OECs were transplanted into normal animal brains, no OECs were phagocytosed by dendritic cells in the cervical lymph node, and OECs did not induce lymphocyte proliferation, which indicates that OECs share some immune privilege under normal conditions. However, OECs in the rat EAE brain were phagocytosed by dendritic cells in the cervical lymph node and enhanced lymphocyte proliferation. These findings suggest that OECs are rejected because of increased immunogenicity in EAE brain, and that brain inflammation, in particular activated dendritic cells, may be a prerequisite for rejecting OECs.
文摘以OBE(Outcome Based Education)教育理念为核心,针对传统课程在教学模式、实践机会、设备与项目以及师资等方面存在的问题,提出了一种基于OBE理念的机电类实验课程改革方案,构建了WHHM实施框架,并以此搭建新工科视域下包含基础层、专业层、综合层和创新层的四层实验课程体系。结合地方产业需求的情境化实验教学实例设计过程,阐述其具体实践过程,提出加强校地交流、建立多渠道反馈机制、基于反馈持续改进教学等建议。
