Addressing the limitations of inadequate stochastic disturbance characterization during wind turbine degradation processes that result in constrained modeling accuracy,replacement-based maintenance practices that devi...Addressing the limitations of inadequate stochastic disturbance characterization during wind turbine degradation processes that result in constrained modeling accuracy,replacement-based maintenance practices that deviate from actual operational conditions,and static maintenance strategies that fail to adapt to accelerated deterioration trends leading to suboptimal remaining useful life utilization,this study proposes a Time-Based Incomplete Maintenance(TBIM)strategy incorporating reliability constraints through stochastic differential equations(SDE).By quantifying stochastic interference via Brownian motion terms and characterizing nonlinear degradation features through state influence rate functions,a high-precision SDE degradation model is constructed,achieving 16%residual reduction compared to conventional ordinary differential equation(ODE)methods.The introduction of age reduction factors and failure rate growth factors establishes an incomplete maintenance mechanism that transcends traditional“as-good-as-new”assumptions,with the TBIM model demonstrating an additional 8.5%residual reduction relative to baseline SDE approaches.A dynamic maintenance interval optimization model driven by dual parameters—preventive maintenance threshold R_(p) and replacement threshold R_(r)—is designed to achieve synergistic optimization of equipment reliability and maintenance economics.Experimental validation demonstrates that the optimized TBIM extends equipment lifespan by 4.4%and reducesmaintenance costs by 4.16%at R_(p)=0.80,while achieving 17.2%lifespan enhancement and 14.6%cost reduction at R_(p)=0.90.This methodology provides a solution for wind turbine preventive maintenance that integrates condition sensitivity with strategic foresight.展开更多
Hangers play a crucial role in transferring loads in suspension bridges,yet their condition often deteriorates faster than expected due to corrosion and fatigue effects.Premature hanger failure poses serious risks to ...Hangers play a crucial role in transferring loads in suspension bridges,yet their condition often deteriorates faster than expected due to corrosion and fatigue effects.Premature hanger failure poses serious risks to bridge safety and results in significant economic loss due to frequent replacement and traffic interruption.To address these challenges,this study proposes an integrated framework to evaluate the life-cycle safety and operational cost of bridge hangers.Traffic data obtained from Weigh-in-Motion(WIM)systems are used to simulate dynamic hanger responses.A wire-to-hanger deterioration model is then employed to capture the time-dependent interaction between corrosion and fatigue under varying environmental conditions.The failure probability of hangers is incorporated into a cost model that accounts for inspection,maintenance,replacement,and traffic disruptions associated with failure.A case study of the Jiangyin Yangtze River Bridge is conducted based on its WIM data and inspection records.The simulation results showthat corrosion-fatigue interaction significantly accelerates hanger degradation.However,timely and effective maintenance measures including anchorage dehumidification can extend service life and reduce total operational costs.The proposed framework provides a practical tool for designing cost-effectivemaintenance strategies and improving the long-term performance of suspension bridge hangers.展开更多
This paper presents an artificial intelligence(AI)-based observer that combines fuzzy logic and neural networks to detect abnormalities in sensors embedded in an electrolyser.Electrolysers are hydrogen production plan...This paper presents an artificial intelligence(AI)-based observer that combines fuzzy logic and neural networks to detect abnormalities in sensors embedded in an electrolyser.Electrolysers are hydrogen production plants that require effective maintenance to guarantee suitable operation,prevent degradation,and avoid loss of efficiency.In this sense,predictive maintenance arises as one of the most advisable techniques for maintenance in electrolysers by using sensor data to predict potential abnormalities.However,if the sensor fails,there will be an incorrect forecasting of abnormalities.Among the different types of operational faults that sensors can present are drift-related faults,which are probably the most difficult to detect due to a slow but progressive loss of accuracy in measurements.Another problem with predictive maintenance is that it often requires enormous training data,which is not available at the early stage of plant operation.The developed fuzzy system is responsible for detecting faulty readings arising from drift sensor signals,while the neural network complements the function of the fuzzy system by predicting sensor signals when enough training data are available.The AI-based observer and the fuzzy rules are validated in an experimental case study with a 1 Nm^(3)/h electrolyser.The selected variables are electrolyser temperature and efficiency.Experimental results show that the rules of the fuzzy component of the AI-based observer guarantee an accuracy of±0.25 within the range of 0 to 1,and the neural network component predicted correct sensor values with a root mean square error(RMSE)as low as 0.0016.The authors’approach helps to determine drift faults without additional sensors or components installed in the plant.展开更多
Modern industrial environments require uninterrupted machinery operation to maintain productivity standards while ensuring safety and minimizing costs.Conventional maintenance methods,such as reactive maintenance(i.e....Modern industrial environments require uninterrupted machinery operation to maintain productivity standards while ensuring safety and minimizing costs.Conventional maintenance methods,such as reactive maintenance(i.e.,run to failure)or time-based preventive maintenance(i.e.,scheduled servicing),prove ineffective for complex systems with many Internet of Things(IoT)devices and sensors because they fall short in detecting faults at early stages when it is most crucial.This paper presents a predictive maintenance framework based on a hybrid deep learning model that integrates the capabilities of Long Short-Term Memory(LSTM)Networks and Convolutional Neural Networks(CNNs).The framework integrates spatial feature extraction and temporal sequence modeling to accurately classify the health state of industrial equipment into three categories,including Normal,Require Maintenance,and Failed.The framework uses a modular pipeline that includes IoT-enabled data collection along with secure transmission methods to manage cloud storage and provide real-time fault classification.The FD004 subset of the NASA C-MAPSS dataset,containing multivariate sensor readings from aircraft engines,serves as the training and evaluation data for the model.Experimental results show that the LSTM-CNN model outperforms baseline models such as LSTM-SVM and LSTM-RNN,achieving an overall average accuracy of 86.66%,precision of 86.00%,recall of 86.33%,and F1-score of 86.33%.Contrary to the previous LSTM-CNN-based predictive maintenance models that either provide a binary classification or rely on synthetically balanced data,our paper provides a three-class maintenance state(i.e.,Normal,Require Maintenance,and Failed)along with threshold-based labeling that retains the true nature of the degradation.In addition,our work also provides an IoT-to-cloud-based modular architecture for deployment.It offers Computerized Maintenance Management System(CMMS)integration,making our proposed solution not only technically sound but also practical and innovative.The solution achieves real-world industrial deployment readiness through its reliable performance alongside its scalable system design.展开更多
With the increasing complexity of industrial automation,planetary gearboxes play a vital role in largescale equipment transmission systems,directly impacting operational efficiency and safety.Traditional maintenance s...With the increasing complexity of industrial automation,planetary gearboxes play a vital role in largescale equipment transmission systems,directly impacting operational efficiency and safety.Traditional maintenance strategies often struggle to accurately predict the degradation process of equipment,leading to excessive maintenance costs or potential failure risks.However,existing prediction methods based on statistical models are difficult to adapt to nonlinear degradation processes.To address these challenges,this study proposes a novel condition-based maintenance framework for planetary gearboxes.A comprehensive full-lifecycle degradation experiment was conducted to collect raw vibration signals,which were then processed using a temporal convolutional network autoencoder with multi-scale perception capability to extract deep temporal degradation features,enabling the collaborative extraction of longperiod meshing frequencies and short-term impact features from the vibration signals.Kernel principal component analysis was employed to fuse and normalize these features,enhancing the characterization of degradation progression.A nonlinear Wiener process was used to model the degradation trajectory,with a threshold decay function introduced to dynamically adjust maintenance strategies,and model parameters optimized through maximum likelihood estimation.Meanwhile,the maintenance strategy was optimized to minimize costs per unit time,determining the optimal maintenance timing and preventive maintenance threshold.The comprehensive indicator of degradation trends extracted by this method reaches 0.756,which is 41.2%higher than that of traditional time-domain features;the dynamic threshold strategy reduces the maintenance cost per unit time to 55.56,which is 8.9%better than that of the static threshold optimization.Experimental results demonstrate significant reductions in maintenance costs while enhancing system reliability and safety.This study realizes the organic integration of deep learning and reliability theory in the maintenance of planetary gearboxes,provides an interpretable solution for the predictive maintenance of complex mechanical systems,and promotes the development of condition-based maintenance strategies for planetary gearboxes.展开更多
Scientific and technological advancements are rapidly transforming underground engineering,shifting from labor-intensive,time-consuming methods to automated,real-time systems.This timely and comprehensive review cover...Scientific and technological advancements are rapidly transforming underground engineering,shifting from labor-intensive,time-consuming methods to automated,real-time systems.This timely and comprehensive review covers in-situ testing,intelligent monitoring,and geophysical testing methods,highlighting fundamental principles,testing apparatuses,data processing techniques,and engineering applications.The state-of-the-art summary emphasizes not only cutting-edge innovations for complex and harsh environments but also the transformative role of artificial intelligence and machine learning in data interpretations.The integration of big data and advanced algorithms is particularly impactful,enabling the identification,prediction,and mitigation of potential risks in underground projects.Key aspects of the discussion include detection capabilities,method integration,and data convergence of intelligent technologies to drive enhanced safety,operational efficiency,and predictive reliability.The review also examines future trends in intelligent technologies,emphasizing unified platforms that combine multiple methods,real-time data,and predictive analytics.These advancements are shaping the evolution of underground construction and maintenance,aiming for risk-free,high-efficiency underground engineering.展开更多
Preventive maintenance(PM)enhances the reliability of an ultra-high-voltage DC(UHVDC)line.However,it introduces new states and complicates the task of determining the reliability parameters of the component with PM.Th...Preventive maintenance(PM)enhances the reliability of an ultra-high-voltage DC(UHVDC)line.However,it introduces new states and complicates the task of determining the reliability parameters of the component with PM.The hierarchical connection(HC)of the inverter improves the flexibility of UHVDC,but the state spaces of the inverter and UHVDC-HC are determined by capacity distribution between the high terminal(HT)and low terminal(LT),which has not been studied yet.In this paper,the reliability of UHVDC-HC with the PM is studied.First,with the impact of PM described by a nonlinear coefficient,the state space of the components with PM is aggregated.It is the same size as without PM.The only difference is the transition rate.Second,considering power distribution between the HT/LT and its dependence on the state of the rectifier,new capacity levels of HT/LT,e.g.,75%/2,50%/3,are defined.Third,with capacity levels of the HT/LT differentiated,2 existing reliability indices are extended,and 2 are newly defined.Finally,a sensitivity model of the reliability of the UHVDC-HC to its parameters and the PM period is proposed.展开更多
BACKGROUND Research examining the relationships among anxiety,depression,self-perceived burden(SPB),and psychological resilience(PR),along with the determinants of PR,in patients with chronic renal failure(CRF)receivi...BACKGROUND Research examining the relationships among anxiety,depression,self-perceived burden(SPB),and psychological resilience(PR),along with the determinants of PR,in patients with chronic renal failure(CRF)receiving maintenance hemodia-lysis(MHD)is limited.AIM To investigate the correlation between anxiety,depression,SPB,and PR in pati-ents with CRF on MHD.METHODS This study included 225 patients with CRF on MHD who were admitted between June 2021 and June 2024.The anxiety level was evaluated using the Self-Rating Anxiety Scale(SAS);the depression status was assessed using the Self-Rating Depression Scale(SDS);the SPB was measured using the SPB Scale(SPBS);and the PR was determined using the Connor–Davidson Resilience Scale(CD-RISC).The correlations among the SAS,SDS,SPB,and CD-RISC were analyzed using Pearson’s correlation coefficients.Univariate and multivariate analyses were performed to identify the factors that influence the PR of patients with CRF on MHD.RESULTS The SAS,SDS,SPB,and CD-RISC scores of the 225 patients were 45.25±15.36,54.81±14.68,32.31±11.52,and 66.48±9.18,respectively.Significant negative correlations were observed between SAS,SDS,SPB,and CD-RISC.Furthermore,longer dialysis vintage(P=0.015),the absence of religious beliefs(P=0.020),lower monthly income(P=0.008),higher SAS score(P=0.013),and higher SDS score(P=0.006)were all independent factors that adversely affected the PR of patients with CRF on MHD.CONCLUSION Patients with CRF on MHD present with varying degrees of anxiety,depression,and SPB,all of which exhibit a significant negative correlation with their PR.Moreover,longer dialysis vintage,the absence of religious beliefs,lower monthly income,higher SAS score,and higher SDS score were factors that negatively affected the PR of patients with CRF on MHD.展开更多
As an essential part of the urban infrastructure,underground utility tunnels have a long service life,complex structural performance evolution and dynamic changes both inside and outside the tunnel.These combined fact...As an essential part of the urban infrastructure,underground utility tunnels have a long service life,complex structural performance evolution and dynamic changes both inside and outside the tunnel.These combined factors result in a wide variety of disaster risks during the operation and maintenance phase,which make risk management and control particularly challenging.This work first reviews three common representative disaster factors during the operation and maintenance period:settlement,earthquakes,and explosions.It summarizes the causes of disasters,key technologies,and research methods.Then,it delves into the research on the intelligent operation and maintenance architecture for utility tunnels.Additionally,it explores the data challenges,monitoring technologies,and management platform architectures faced during the operation and maintenance process.This work provides new research perspectives for the long-term,healthy,and sustainable development of utility tunnels,which serve as the underground arteries of cities.展开更多
This study proposes a novel visual maintenance method for photovoltaic(PV)modules based on a two-stage Wiener degradation model,addressing the limitations of traditional PV maintenance strategies that often result in ...This study proposes a novel visual maintenance method for photovoltaic(PV)modules based on a two-stage Wiener degradation model,addressing the limitations of traditional PV maintenance strategies that often result in insufficient or excessive maintenance.The approach begins by constructing a two-stage Wiener process performance degradation model and a remaining life prediction model under perfect maintenance conditions using historical degradation data of PV modules.This enables accurate determination of the optimal timing for postfailure corrective maintenance.To optimize the maintenance strategy,the study establishes a comprehensive cost model aimed at minimizing the long-term average cost rate.The model considers multiple cost factors,including inspection costs,preventive maintenance costs,restorative maintenance costs,and penalty costs associated with delayed fault detection.Through this optimization framework,the method determines both the optimal maintenance threshold and the ideal timing for predictive maintenance actions.Comparative analysis demonstrates that the twostage Wiener model provides superior fitting performance compared to conventional linear and nonlinear degradation models.When evaluated against traditional maintenance approaches,including Wiener process-based corrective maintenance strategies and static periodic maintenance strategies,the proposed method demonstrates significant advantages in reducing overall operational costs while extending the effective service life of PV components.The method achieves these improvements through effective coordination between reliability optimization and economic benefit maximization,leading to enhanced power generation performance.These results indicate that the proposed approach offers a more balanced and efficient solution for PV system maintenance.展开更多
This paper presents a project aimed at developing a trilingual visual dictionary for aircraft maintenance professionals and students.The project addresses the growing demand for accurate communication and technical te...This paper presents a project aimed at developing a trilingual visual dictionary for aircraft maintenance professionals and students.The project addresses the growing demand for accurate communication and technical terminology in the aviation industry,particularly in Brazil and China.The study employs a corpus-driven approach,analyzing a large corpus of aircraft maintenance manuals to extract key technical terms and their collocates.Using specialized subcorpora and a comparative analysis,this paper demonstrates challenges and solutions into the identification of high-frequency keywords and explores their contextual use in aviation documentation,emphasizing the need for clear and accurate technical communication.By incorporating these findings into a trilingual visual dictionary,the project aims to enhance the understanding and usage of aviation terminology.展开更多
Tunnel facility management(FM)is crucial for ensuring safety,efficiency,and resilience of tunnel infrastructure.Current FM practices,such as reactive and preventive maintenance,have limitations-reactive maintenance ca...Tunnel facility management(FM)is crucial for ensuring safety,efficiency,and resilience of tunnel infrastructure.Current FM practices,such as reactive and preventive maintenance,have limitations-reactive maintenance can't prevent failures,and preventive maintenance can't predict asset maintenance needs,leading to costly and inefficient processes.In addition,existing computerized tunnel FM systems face various challenges,including the lack of integrated real-time monitoring information,visualization of assets in a three-dimensional(3D)environment,supporting predictive maintenance,and scaling into long infrastructure with complicated spatiotemporal relationships.This study addresses these limitations by proposing a data-driven digital twin(DT)-based framework that supports predictive maintenance to improve tunnel FM processes and enhance resilience.The proposed framework consists of six layers,allowing the integration of data from monitoring system,FM system,and building information modeling(BIM)models.The framework proposes a flexible tunnel data model and classification system that hierarchically divides the tunnel models,ensuring an efficient data connection from the physical twin to the DT.The system was implemented in a tunnel case study that generates maintenance plans and work orders using historical and current condition monitoring data,and the 3D visualization technology suggests maintenance and repair processes,making the FM decision process more effective.The proposed system detected and predicted the twin state based on a data-driven analysis,and the prediction accuracy of the machine learning models was sufficiently high for use in real scenarios to make FM plans in advance and prevent asset failures.The proposed framework is contributing to the infrastructure resilience by enhancing the tunnel system ability to predict the maintenance tasks and prevent failures using data-driven DT technology.展开更多
BACKGROUND Eosinophilic esophagitis(EoE)is a chronic inflammatory disorder presenting as symptoms of dysphagia,esophageal food impaction,chest pain,and heartburn.After an initial trial of proton pump inhibitor(PPI)the...BACKGROUND Eosinophilic esophagitis(EoE)is a chronic inflammatory disorder presenting as symptoms of dysphagia,esophageal food impaction,chest pain,and heartburn.After an initial trial of proton pump inhibitor(PPI)therapy,swallowed topical corticosteroids(STC)are effective as induction therapy for EoE.However,out-come data for STC as a maintenance strategy is limited.RESULTS Three randomized control trials and one observational study were included,involving 303 patients(189 in the STC group,114 in the placebo-controlled group).Analysis showed that histologic recurrence was significantly lower with STC(OR:0.04,95%CI:0.01-0.28,P<0.00001,I^(2)=78%).Overall symptom recurrence was similar between groups(OR:0.23,95%CI:0.02-3.54,P=0.29,I^(2)=92%).On sensitivity analysis,symptom recurrence was significantly lower in the STC group(OR:0.05,95%CI:0.02-0.17,P=0.00001,I^(2)=39%).Odds of repeat dilation were significantly lower in the STC group(OR:0.14,95%CI:0.02-0.91,P=0.04,I^(2)=0%).Candida infection rates were similar between groups(OR:6.13,95%CI:0.85-44.26,P=0.07,I^(2)=24%).Proportion of concomitant PPI use was similar between groups(OR:1.64,95%CI:0.83-3.21,P=0.15,I^(2)=0%).CONCLUSION For patients who successfully achieved remission of EoE with STC induction therapy,maintaining treatment is effective in sustaining histologic remission,while newer regimens may be effective in preventing symptom recurrence compared to placebo.We found no significant difference for oropharyngeal/esophageal candidiasis with STC maintenance therapy.Future studies with longer follow-up periods are needed.展开更多
The fractionating tower bottom in fluid catalytic cracking Unit (FCCU) is highly susceptible to coking due to the interplay of complex external operating conditions and internal physical properties. Consequently, quan...The fractionating tower bottom in fluid catalytic cracking Unit (FCCU) is highly susceptible to coking due to the interplay of complex external operating conditions and internal physical properties. Consequently, quantitative risk assessment (QRA) and predictive maintenance (PdM) are essential to effectively manage coking risks influenced by multiple factors. However, the inherent uncertainties of the coking process, combined with the mixed-frequency nature of distributed control systems (DCS) and laboratory information management systems (LIMS) data, present significant challenges for the application of data-driven methods and their practical implementation in industrial environments. This study proposes a hierarchical framework that integrates deep learning and fuzzy logic inference, leveraging data and domain knowledge to monitor the coking condition and inform prescriptive maintenance planning. The framework proposes the multi-layer fuzzy inference system to construct the coking risk index, utilizes multi-label methods to select the optimal feature dataset across the reactor-regenerator and fractionation system using coking risk factors as label space, and designs the parallel encoder-integrated decoder architecture to address mixed-frequency data disparities and enhance adaptation capabilities through extracting the operation state and physical properties information. Additionally, triple attention mechanisms, whether in parallel or temporal modules, adaptively aggregate input information and enhance intrinsic interpretability to support the disposal decision-making. Applied in the 2.8 million tons FCCU under long-period complex operating conditions, enabling precise coking risk management at the fractionating tower bottom.展开更多
Objective:To investigate the differential effects of different rivaroxaban dosing regimens on symptom relief,fluctuations in laboratory parameters,and medication safety in patients with stable pulmonary embolism(PE).M...Objective:To investigate the differential effects of different rivaroxaban dosing regimens on symptom relief,fluctuations in laboratory parameters,and medication safety in patients with stable pulmonary embolism(PE).Methods:This study enrolled 100 patients in the maintenance phase of PE who were treated at our hospital between January 2022 and December 2023.They were randomly divided into a control group and an observation group using a random number table,with 50 subjects in each group.The treatment period was uniformly set at 6 months.The control group received oral rivaroxaban 10 mg once daily,while the observation group received oral rivaroxaban 5 mg once daily.The study focused on comparing the two groups regarding the degree of clinical symptom relief,coagulation function parameters(including D-dimer levels,PT,and APTT),cardiac function markers(NT-proBNP),and drug-related adverse events.All data were processed using SPSS 26.0 statistical software.Measurement data are presented as mean±standard deviation,intergroup differences were verified by t-test,categorical variables were analyzed by chi-square test,and the statistical significance level was set at P<0.05.Results:After six months of treatment intervention,there was no significant difference in the overall relief of core clinical symptoms such as dyspnea and chest pain between the two groups.Regarding laboratory indicators,post-treatment D-dimer levels,prothrombin time,activated partial thromboplastin time,and NT-proBNP values were significantly optimized compared to baseline in both groups(P<0.05),but intergroup comparisons did not reach statistical significance.Notably,the overall incidence of bleeding events in the observation group was significantly lower than that in the control group(P<0.05),while there were no significant differences in the incidence rates of other adverse events between the two groups.Conclusion:In the maintenance phase treatment of pulmonary embolism,rivaroxaban 5 mg and 10 mg doses are equivalent in efficacy regarding improvement of clinical symptoms and blood indicators.However,the 5 mg dose significantly reduces the risk of bleeding,offers better safety,and is more suitable for long-term anticoagulation management in some high-risk populations.展开更多
Preventing the recurrence of lung oligometastases after local therapy in patients with colorectal cancer is an area requiring investigation.A recent article demonstrated that adding capecitabine maintenance therapy af...Preventing the recurrence of lung oligometastases after local therapy in patients with colorectal cancer is an area requiring investigation.A recent article demonstrated that adding capecitabine maintenance therapy after radiofrequency ablation improved the 5-year overall survival(88.7%vs 69.1%)and reduced local tumor progression(22.7%vs 49.0%)compared with radiofrequency ablation alone.Although progression-free survival did not differ significantly between the two treatments,multivariate analysis confirmed a robust survival benefit.These findings support the use of systemic maintenance to eradicate micrometastases after locoregional control and warrant validation in prospective randomized trials.展开更多
BACKGROUND No clear guidelines for long-term postoperative maintenance therapy have been established for patients with lung oligometastases from colorectal cancer(CRC)who achieve radiological no evidence of disease af...BACKGROUND No clear guidelines for long-term postoperative maintenance therapy have been established for patients with lung oligometastases from colorectal cancer(CRC)who achieve radiological no evidence of disease after radiofrequency ablation(RFA)treatment.We compared the outcomes of patients with lung oligometa-stases from CRC after RFA plus maintenance capecitabine with RFA alone.AIM To determine whether adding capecitabine to RFA improves prognosis compared with RFA alone.METHODS This multicenter retrospective study included consecutive patients from two tertiary cancer centers treated for pulmonary oligometastases from CRC between 2016 and 2023.Subjects were assigned to RFA plus capecitabine(combined)or RFA alone(only RFA)groups.Primary outcomes included overall survival(OS)and progression-free survival(PFS)survival and the secondary outcome was local tumor progression(LTP).The OS,PFS,and LTP rates were compared between the two groups.In addition,prognostic factors were identified using univariate and multivariate analyses.RESULTS Combination therapy(RFA+capecitabine,n=148)and RFA monotherapy(n=99)were compared in patients with CRC and lung metastases.The median OS was 37.8 months(22.4,50.3),the PFS was 18.7 months(13.0,36.5),and the LTP was 31.5 months(20.0,52.4)in the Only RFA group.The OS increased significantly(P=0.011)and the LTP decreased at all time points(P<0.001)in the combined group.The multivariate cox analysis revealed that combined chemotherapy significantly improved OS,with hazard ratios ranging from 0.29 to 0.35(all P<0.015)after adjusting for demographic,tumor,and treatment-related factors.The risk of death was consistently lower in the combination therapy group compared to RFA monotherapy.CONCLUSION RFA prolongs survival and local control in patients with CRC pulmonary oligometastases.Adjuvant capecitabine increases OS and reduces LTP compared to RFA alone,but PFS did not significantly change.展开更多
This study focuses on the management of maintenance hemodialysis(MHD)patients,with a specific emphasis on the practical application effect of the network information management model including its impact on patients’...This study focuses on the management of maintenance hemodialysis(MHD)patients,with a specific emphasis on the practical application effect of the network information management model including its impact on patients’compliance.A network information management model for MHD patients was constructed around three management schemes:“software reminders+follow-up guidance”,“dietary records+self-management reminders”,and“dialysis plan+precise weight management”.These schemes were respectively used to optimize anemia management,control the risk of hyperphosphatemia,and improve toxin clearance efficiency.A controlled experiment was conducted,with an experimental group and a control group set up for comparative practice.The results showed that the network information management model can effectively improve patients’anemia,help alleviate mineral metabolism disorders and the accumulation of small-molecule toxins,and exert a positive impact on patients’treatment compliance.展开更多
This paper investigates the selective maintenance o systems that perform multi-mission in succession. Selective maintenance is performed on systems with limited break time to improve the success of the next mission. I...This paper investigates the selective maintenance o systems that perform multi-mission in succession. Selective maintenance is performed on systems with limited break time to improve the success of the next mission. In general, the duration of the mission is stochastic. However, existing studies rarely take into account system availability and the repairpersons with different skill levels. To solve this problem, a new multi-mission selective maintenance and repairpersons assignment model with stochastic duration of the mission are developed. To maximize the minimum phase-mission reliability while meeting the minimum system availability, the model is transformed into an optimization problem subject to limited maintenance resources. The optimization is then realized using an analytical method based on a self-programming function and a Monte Carlo simulation method, respectively. Finally, the validity of the model and solution method approaches are verified by numerical arithmetic examples. Comparative and sensitivity analyses are made to provide proven recommendations for decision-makers.展开更多
The “3·31” severe squall line event in eastern China was notable for its exceptional intensity and persistence,posing significant challenges to forecast accuracy. This study analyzed the maintenance stage of th...The “3·31” severe squall line event in eastern China was notable for its exceptional intensity and persistence,posing significant challenges to forecast accuracy. This study analyzed the maintenance stage of this event using highresolution convection-permitting numerical simulations, with a focus on vorticity budgets of the environmental flow, multiscale synoptic diagnostics, and Rotunno-Klemp-Weisman(RKW) theory. These analyses aimed to elucidate the mechanisms governing the morphological transition, the generation of associated convective gales, and the prolonged maintenance of the squall line event. The results show that the numerical simulation accurately reproduced the development and evolution of the squall line, particularly its location, with surface wind errors remaining within a reasonable range. The development of a mesoscale vortex modulated the dynamic and water vapor fields, providing favorable mesoscale environmental conditions for the organization and maintenance of the squall line. Vorticity budget analysis indicates that the divergence and tilting terms were the primary contributors to vorticity tendency. After the squall line entered Jiangxi Province, it exhibited a sharper leading edge and enhanced upward motion. Dry intrusion from the mid-toupper troposphere led to rapid downward momentum transfer at the meso-γ scale, thereby generating convective gales. In addition, the enhancement of the rear-inflow jet(RIJ) was related to the pressure difference between the interior and exterior of system, which resulted from the phase change of condensate within tilted updrafts. The RIJ was orthogonal to the squall line, causing it to transform from a linear into a bowing shape. Diagnosis based on the RKW theory underscore the important roles in both low-level and deep vertical wind shear in maintenaning the squall line. The ratios of the cold pool propagation velocity to the vertical wind shear were close to 1, which balanced with the ambient horizontal vorticity that allowed the convection to remain upright, thus sustaining the squall line's intensity for an extended period. In summary, the squall line event was sustained by a favorable environment created by the environmental vortex. The dry intrusion from the mid-to-upper troposphere and intensified RIJ resulted in the severe convective winds, while the balance between cold pool and ambient vertical wind shear promoted the system's prolonged maintenance. These findings provide an effective reference for the short-range forecasting of squall lines throughout their lifecycle.展开更多
基金supported in part by the National Natural Science Foundation of China(No.52467008)Gansu Provincial Depatment of Education Youth Doctoral Suppo Project(2024QB-051).
文摘Addressing the limitations of inadequate stochastic disturbance characterization during wind turbine degradation processes that result in constrained modeling accuracy,replacement-based maintenance practices that deviate from actual operational conditions,and static maintenance strategies that fail to adapt to accelerated deterioration trends leading to suboptimal remaining useful life utilization,this study proposes a Time-Based Incomplete Maintenance(TBIM)strategy incorporating reliability constraints through stochastic differential equations(SDE).By quantifying stochastic interference via Brownian motion terms and characterizing nonlinear degradation features through state influence rate functions,a high-precision SDE degradation model is constructed,achieving 16%residual reduction compared to conventional ordinary differential equation(ODE)methods.The introduction of age reduction factors and failure rate growth factors establishes an incomplete maintenance mechanism that transcends traditional“as-good-as-new”assumptions,with the TBIM model demonstrating an additional 8.5%residual reduction relative to baseline SDE approaches.A dynamic maintenance interval optimization model driven by dual parameters—preventive maintenance threshold R_(p) and replacement threshold R_(r)—is designed to achieve synergistic optimization of equipment reliability and maintenance economics.Experimental validation demonstrates that the optimized TBIM extends equipment lifespan by 4.4%and reducesmaintenance costs by 4.16%at R_(p)=0.80,while achieving 17.2%lifespan enhancement and 14.6%cost reduction at R_(p)=0.90.This methodology provides a solution for wind turbine preventive maintenance that integrates condition sensitivity with strategic foresight.
基金supported by the Academician Project Foundation of CCCC(YSZX-01-2022-01-B,YSZX-03-2025-02-B).
文摘Hangers play a crucial role in transferring loads in suspension bridges,yet their condition often deteriorates faster than expected due to corrosion and fatigue effects.Premature hanger failure poses serious risks to bridge safety and results in significant economic loss due to frequent replacement and traffic interruption.To address these challenges,this study proposes an integrated framework to evaluate the life-cycle safety and operational cost of bridge hangers.Traffic data obtained from Weigh-in-Motion(WIM)systems are used to simulate dynamic hanger responses.A wire-to-hanger deterioration model is then employed to capture the time-dependent interaction between corrosion and fatigue under varying environmental conditions.The failure probability of hangers is incorporated into a cost model that accounts for inspection,maintenance,replacement,and traffic disruptions associated with failure.A case study of the Jiangyin Yangtze River Bridge is conducted based on its WIM data and inspection records.The simulation results showthat corrosion-fatigue interaction significantly accelerates hanger degradation.However,timely and effective maintenance measures including anchorage dehumidification can extend service life and reduce total operational costs.The proposed framework provides a practical tool for designing cost-effectivemaintenance strategies and improving the long-term performance of suspension bridge hangers.
基金support of(1)Grant Ref.PID2023-148456OB-C41 and(2)Grant Ref.RED2022-134588-T found by MICIU/AEI/10.13039/501100011033。
文摘This paper presents an artificial intelligence(AI)-based observer that combines fuzzy logic and neural networks to detect abnormalities in sensors embedded in an electrolyser.Electrolysers are hydrogen production plants that require effective maintenance to guarantee suitable operation,prevent degradation,and avoid loss of efficiency.In this sense,predictive maintenance arises as one of the most advisable techniques for maintenance in electrolysers by using sensor data to predict potential abnormalities.However,if the sensor fails,there will be an incorrect forecasting of abnormalities.Among the different types of operational faults that sensors can present are drift-related faults,which are probably the most difficult to detect due to a slow but progressive loss of accuracy in measurements.Another problem with predictive maintenance is that it often requires enormous training data,which is not available at the early stage of plant operation.The developed fuzzy system is responsible for detecting faulty readings arising from drift sensor signals,while the neural network complements the function of the fuzzy system by predicting sensor signals when enough training data are available.The AI-based observer and the fuzzy rules are validated in an experimental case study with a 1 Nm^(3)/h electrolyser.The selected variables are electrolyser temperature and efficiency.Experimental results show that the rules of the fuzzy component of the AI-based observer guarantee an accuracy of±0.25 within the range of 0 to 1,and the neural network component predicted correct sensor values with a root mean square error(RMSE)as low as 0.0016.The authors’approach helps to determine drift faults without additional sensors or components installed in the plant.
文摘Modern industrial environments require uninterrupted machinery operation to maintain productivity standards while ensuring safety and minimizing costs.Conventional maintenance methods,such as reactive maintenance(i.e.,run to failure)or time-based preventive maintenance(i.e.,scheduled servicing),prove ineffective for complex systems with many Internet of Things(IoT)devices and sensors because they fall short in detecting faults at early stages when it is most crucial.This paper presents a predictive maintenance framework based on a hybrid deep learning model that integrates the capabilities of Long Short-Term Memory(LSTM)Networks and Convolutional Neural Networks(CNNs).The framework integrates spatial feature extraction and temporal sequence modeling to accurately classify the health state of industrial equipment into three categories,including Normal,Require Maintenance,and Failed.The framework uses a modular pipeline that includes IoT-enabled data collection along with secure transmission methods to manage cloud storage and provide real-time fault classification.The FD004 subset of the NASA C-MAPSS dataset,containing multivariate sensor readings from aircraft engines,serves as the training and evaluation data for the model.Experimental results show that the LSTM-CNN model outperforms baseline models such as LSTM-SVM and LSTM-RNN,achieving an overall average accuracy of 86.66%,precision of 86.00%,recall of 86.33%,and F1-score of 86.33%.Contrary to the previous LSTM-CNN-based predictive maintenance models that either provide a binary classification or rely on synthetically balanced data,our paper provides a three-class maintenance state(i.e.,Normal,Require Maintenance,and Failed)along with threshold-based labeling that retains the true nature of the degradation.In addition,our work also provides an IoT-to-cloud-based modular architecture for deployment.It offers Computerized Maintenance Management System(CMMS)integration,making our proposed solution not only technically sound but also practical and innovative.The solution achieves real-world industrial deployment readiness through its reliable performance alongside its scalable system design.
基金funded by scientific research projects under Grant JY2024B011.
文摘With the increasing complexity of industrial automation,planetary gearboxes play a vital role in largescale equipment transmission systems,directly impacting operational efficiency and safety.Traditional maintenance strategies often struggle to accurately predict the degradation process of equipment,leading to excessive maintenance costs or potential failure risks.However,existing prediction methods based on statistical models are difficult to adapt to nonlinear degradation processes.To address these challenges,this study proposes a novel condition-based maintenance framework for planetary gearboxes.A comprehensive full-lifecycle degradation experiment was conducted to collect raw vibration signals,which were then processed using a temporal convolutional network autoencoder with multi-scale perception capability to extract deep temporal degradation features,enabling the collaborative extraction of longperiod meshing frequencies and short-term impact features from the vibration signals.Kernel principal component analysis was employed to fuse and normalize these features,enhancing the characterization of degradation progression.A nonlinear Wiener process was used to model the degradation trajectory,with a threshold decay function introduced to dynamically adjust maintenance strategies,and model parameters optimized through maximum likelihood estimation.Meanwhile,the maintenance strategy was optimized to minimize costs per unit time,determining the optimal maintenance timing and preventive maintenance threshold.The comprehensive indicator of degradation trends extracted by this method reaches 0.756,which is 41.2%higher than that of traditional time-domain features;the dynamic threshold strategy reduces the maintenance cost per unit time to 55.56,which is 8.9%better than that of the static threshold optimization.Experimental results demonstrate significant reductions in maintenance costs while enhancing system reliability and safety.This study realizes the organic integration of deep learning and reliability theory in the maintenance of planetary gearboxes,provides an interpretable solution for the predictive maintenance of complex mechanical systems,and promotes the development of condition-based maintenance strategies for planetary gearboxes.
基金supported by Ministry of Education of Singapore,under Academic Research Fund Tier 1(Grant Number RG143/23).
文摘Scientific and technological advancements are rapidly transforming underground engineering,shifting from labor-intensive,time-consuming methods to automated,real-time systems.This timely and comprehensive review covers in-situ testing,intelligent monitoring,and geophysical testing methods,highlighting fundamental principles,testing apparatuses,data processing techniques,and engineering applications.The state-of-the-art summary emphasizes not only cutting-edge innovations for complex and harsh environments but also the transformative role of artificial intelligence and machine learning in data interpretations.The integration of big data and advanced algorithms is particularly impactful,enabling the identification,prediction,and mitigation of potential risks in underground projects.Key aspects of the discussion include detection capabilities,method integration,and data convergence of intelligent technologies to drive enhanced safety,operational efficiency,and predictive reliability.The review also examines future trends in intelligent technologies,emphasizing unified platforms that combine multiple methods,real-time data,and predictive analytics.These advancements are shaping the evolution of underground construction and maintenance,aiming for risk-free,high-efficiency underground engineering.
基金supported by the National Natural Science Foundation of China(51877061).
文摘Preventive maintenance(PM)enhances the reliability of an ultra-high-voltage DC(UHVDC)line.However,it introduces new states and complicates the task of determining the reliability parameters of the component with PM.The hierarchical connection(HC)of the inverter improves the flexibility of UHVDC,but the state spaces of the inverter and UHVDC-HC are determined by capacity distribution between the high terminal(HT)and low terminal(LT),which has not been studied yet.In this paper,the reliability of UHVDC-HC with the PM is studied.First,with the impact of PM described by a nonlinear coefficient,the state space of the components with PM is aggregated.It is the same size as without PM.The only difference is the transition rate.Second,considering power distribution between the HT/LT and its dependence on the state of the rectifier,new capacity levels of HT/LT,e.g.,75%/2,50%/3,are defined.Third,with capacity levels of the HT/LT differentiated,2 existing reliability indices are extended,and 2 are newly defined.Finally,a sensitivity model of the reliability of the UHVDC-HC to its parameters and the PM period is proposed.
基金Supported by Key Research Fund of Wannan Medical College,No.WK2021ZF15Research Foundation for Advanced Talents of Wannan Medical College,No.YR202213+3 种基金Foundation of Anhui Educational Committee,No.2023AH051759Excellent Youth Research Project of Anhui UniversitiesNo.2023AH030107Horizontal Project of Wannan Medical College,No.622202504003 and No.662202404013.
文摘BACKGROUND Research examining the relationships among anxiety,depression,self-perceived burden(SPB),and psychological resilience(PR),along with the determinants of PR,in patients with chronic renal failure(CRF)receiving maintenance hemodia-lysis(MHD)is limited.AIM To investigate the correlation between anxiety,depression,SPB,and PR in pati-ents with CRF on MHD.METHODS This study included 225 patients with CRF on MHD who were admitted between June 2021 and June 2024.The anxiety level was evaluated using the Self-Rating Anxiety Scale(SAS);the depression status was assessed using the Self-Rating Depression Scale(SDS);the SPB was measured using the SPB Scale(SPBS);and the PR was determined using the Connor–Davidson Resilience Scale(CD-RISC).The correlations among the SAS,SDS,SPB,and CD-RISC were analyzed using Pearson’s correlation coefficients.Univariate and multivariate analyses were performed to identify the factors that influence the PR of patients with CRF on MHD.RESULTS The SAS,SDS,SPB,and CD-RISC scores of the 225 patients were 45.25±15.36,54.81±14.68,32.31±11.52,and 66.48±9.18,respectively.Significant negative correlations were observed between SAS,SDS,SPB,and CD-RISC.Furthermore,longer dialysis vintage(P=0.015),the absence of religious beliefs(P=0.020),lower monthly income(P=0.008),higher SAS score(P=0.013),and higher SDS score(P=0.006)were all independent factors that adversely affected the PR of patients with CRF on MHD.CONCLUSION Patients with CRF on MHD present with varying degrees of anxiety,depression,and SPB,all of which exhibit a significant negative correlation with their PR.Moreover,longer dialysis vintage,the absence of religious beliefs,lower monthly income,higher SAS score,and higher SDS score were factors that negatively affected the PR of patients with CRF on MHD.
基金financially supported by the Scientific Research Projects of the Education Department of Zhejiang Province(Grant No.Y202454744)the Ningbo Public Welfare Science and Technology Project(Grant Nos.2023S007 and 2023S165)the Key Research and Development Program of Zhejiang(Grant No.2023C03183).
文摘As an essential part of the urban infrastructure,underground utility tunnels have a long service life,complex structural performance evolution and dynamic changes both inside and outside the tunnel.These combined factors result in a wide variety of disaster risks during the operation and maintenance phase,which make risk management and control particularly challenging.This work first reviews three common representative disaster factors during the operation and maintenance period:settlement,earthquakes,and explosions.It summarizes the causes of disasters,key technologies,and research methods.Then,it delves into the research on the intelligent operation and maintenance architecture for utility tunnels.Additionally,it explores the data challenges,monitoring technologies,and management platform architectures faced during the operation and maintenance process.This work provides new research perspectives for the long-term,healthy,and sustainable development of utility tunnels,which serve as the underground arteries of cities.
基金supported by the National Natural Science Foundation of China(51767017)the Basic Research Innovation Group Project of Gansu Province(18JR3RA133)the Industrial Support and Guidance Project of Universities in Gansu Province(2022CYZC-22).
文摘This study proposes a novel visual maintenance method for photovoltaic(PV)modules based on a two-stage Wiener degradation model,addressing the limitations of traditional PV maintenance strategies that often result in insufficient or excessive maintenance.The approach begins by constructing a two-stage Wiener process performance degradation model and a remaining life prediction model under perfect maintenance conditions using historical degradation data of PV modules.This enables accurate determination of the optimal timing for postfailure corrective maintenance.To optimize the maintenance strategy,the study establishes a comprehensive cost model aimed at minimizing the long-term average cost rate.The model considers multiple cost factors,including inspection costs,preventive maintenance costs,restorative maintenance costs,and penalty costs associated with delayed fault detection.Through this optimization framework,the method determines both the optimal maintenance threshold and the ideal timing for predictive maintenance actions.Comparative analysis demonstrates that the twostage Wiener model provides superior fitting performance compared to conventional linear and nonlinear degradation models.When evaluated against traditional maintenance approaches,including Wiener process-based corrective maintenance strategies and static periodic maintenance strategies,the proposed method demonstrates significant advantages in reducing overall operational costs while extending the effective service life of PV components.The method achieves these improvements through effective coordination between reliability optimization and economic benefit maximization,leading to enhanced power generation performance.These results indicate that the proposed approach offers a more balanced and efficient solution for PV system maintenance.
文摘This paper presents a project aimed at developing a trilingual visual dictionary for aircraft maintenance professionals and students.The project addresses the growing demand for accurate communication and technical terminology in the aviation industry,particularly in Brazil and China.The study employs a corpus-driven approach,analyzing a large corpus of aircraft maintenance manuals to extract key technical terms and their collocates.Using specialized subcorpora and a comparative analysis,this paper demonstrates challenges and solutions into the identification of high-frequency keywords and explores their contextual use in aviation documentation,emphasizing the need for clear and accurate technical communication.By incorporating these findings into a trilingual visual dictionary,the project aims to enhance the understanding and usage of aviation terminology.
文摘Tunnel facility management(FM)is crucial for ensuring safety,efficiency,and resilience of tunnel infrastructure.Current FM practices,such as reactive and preventive maintenance,have limitations-reactive maintenance can't prevent failures,and preventive maintenance can't predict asset maintenance needs,leading to costly and inefficient processes.In addition,existing computerized tunnel FM systems face various challenges,including the lack of integrated real-time monitoring information,visualization of assets in a three-dimensional(3D)environment,supporting predictive maintenance,and scaling into long infrastructure with complicated spatiotemporal relationships.This study addresses these limitations by proposing a data-driven digital twin(DT)-based framework that supports predictive maintenance to improve tunnel FM processes and enhance resilience.The proposed framework consists of six layers,allowing the integration of data from monitoring system,FM system,and building information modeling(BIM)models.The framework proposes a flexible tunnel data model and classification system that hierarchically divides the tunnel models,ensuring an efficient data connection from the physical twin to the DT.The system was implemented in a tunnel case study that generates maintenance plans and work orders using historical and current condition monitoring data,and the 3D visualization technology suggests maintenance and repair processes,making the FM decision process more effective.The proposed system detected and predicted the twin state based on a data-driven analysis,and the prediction accuracy of the machine learning models was sufficiently high for use in real scenarios to make FM plans in advance and prevent asset failures.The proposed framework is contributing to the infrastructure resilience by enhancing the tunnel system ability to predict the maintenance tasks and prevent failures using data-driven DT technology.
文摘BACKGROUND Eosinophilic esophagitis(EoE)is a chronic inflammatory disorder presenting as symptoms of dysphagia,esophageal food impaction,chest pain,and heartburn.After an initial trial of proton pump inhibitor(PPI)therapy,swallowed topical corticosteroids(STC)are effective as induction therapy for EoE.However,out-come data for STC as a maintenance strategy is limited.RESULTS Three randomized control trials and one observational study were included,involving 303 patients(189 in the STC group,114 in the placebo-controlled group).Analysis showed that histologic recurrence was significantly lower with STC(OR:0.04,95%CI:0.01-0.28,P<0.00001,I^(2)=78%).Overall symptom recurrence was similar between groups(OR:0.23,95%CI:0.02-3.54,P=0.29,I^(2)=92%).On sensitivity analysis,symptom recurrence was significantly lower in the STC group(OR:0.05,95%CI:0.02-0.17,P=0.00001,I^(2)=39%).Odds of repeat dilation were significantly lower in the STC group(OR:0.14,95%CI:0.02-0.91,P=0.04,I^(2)=0%).Candida infection rates were similar between groups(OR:6.13,95%CI:0.85-44.26,P=0.07,I^(2)=24%).Proportion of concomitant PPI use was similar between groups(OR:1.64,95%CI:0.83-3.21,P=0.15,I^(2)=0%).CONCLUSION For patients who successfully achieved remission of EoE with STC induction therapy,maintaining treatment is effective in sustaining histologic remission,while newer regimens may be effective in preventing symptom recurrence compared to placebo.We found no significant difference for oropharyngeal/esophageal candidiasis with STC maintenance therapy.Future studies with longer follow-up periods are needed.
基金financially supported by the Innovative Research Group Project of the National Natural Science Foundation of China (22021004)Sinopec Major Science and Technology Projects (321123-1)
文摘The fractionating tower bottom in fluid catalytic cracking Unit (FCCU) is highly susceptible to coking due to the interplay of complex external operating conditions and internal physical properties. Consequently, quantitative risk assessment (QRA) and predictive maintenance (PdM) are essential to effectively manage coking risks influenced by multiple factors. However, the inherent uncertainties of the coking process, combined with the mixed-frequency nature of distributed control systems (DCS) and laboratory information management systems (LIMS) data, present significant challenges for the application of data-driven methods and their practical implementation in industrial environments. This study proposes a hierarchical framework that integrates deep learning and fuzzy logic inference, leveraging data and domain knowledge to monitor the coking condition and inform prescriptive maintenance planning. The framework proposes the multi-layer fuzzy inference system to construct the coking risk index, utilizes multi-label methods to select the optimal feature dataset across the reactor-regenerator and fractionation system using coking risk factors as label space, and designs the parallel encoder-integrated decoder architecture to address mixed-frequency data disparities and enhance adaptation capabilities through extracting the operation state and physical properties information. Additionally, triple attention mechanisms, whether in parallel or temporal modules, adaptively aggregate input information and enhance intrinsic interpretability to support the disposal decision-making. Applied in the 2.8 million tons FCCU under long-period complex operating conditions, enabling precise coking risk management at the fractionating tower bottom.
文摘Objective:To investigate the differential effects of different rivaroxaban dosing regimens on symptom relief,fluctuations in laboratory parameters,and medication safety in patients with stable pulmonary embolism(PE).Methods:This study enrolled 100 patients in the maintenance phase of PE who were treated at our hospital between January 2022 and December 2023.They were randomly divided into a control group and an observation group using a random number table,with 50 subjects in each group.The treatment period was uniformly set at 6 months.The control group received oral rivaroxaban 10 mg once daily,while the observation group received oral rivaroxaban 5 mg once daily.The study focused on comparing the two groups regarding the degree of clinical symptom relief,coagulation function parameters(including D-dimer levels,PT,and APTT),cardiac function markers(NT-proBNP),and drug-related adverse events.All data were processed using SPSS 26.0 statistical software.Measurement data are presented as mean±standard deviation,intergroup differences were verified by t-test,categorical variables were analyzed by chi-square test,and the statistical significance level was set at P<0.05.Results:After six months of treatment intervention,there was no significant difference in the overall relief of core clinical symptoms such as dyspnea and chest pain between the two groups.Regarding laboratory indicators,post-treatment D-dimer levels,prothrombin time,activated partial thromboplastin time,and NT-proBNP values were significantly optimized compared to baseline in both groups(P<0.05),but intergroup comparisons did not reach statistical significance.Notably,the overall incidence of bleeding events in the observation group was significantly lower than that in the control group(P<0.05),while there were no significant differences in the incidence rates of other adverse events between the two groups.Conclusion:In the maintenance phase treatment of pulmonary embolism,rivaroxaban 5 mg and 10 mg doses are equivalent in efficacy regarding improvement of clinical symptoms and blood indicators.However,the 5 mg dose significantly reduces the risk of bleeding,offers better safety,and is more suitable for long-term anticoagulation management in some high-risk populations.
文摘Preventing the recurrence of lung oligometastases after local therapy in patients with colorectal cancer is an area requiring investigation.A recent article demonstrated that adding capecitabine maintenance therapy after radiofrequency ablation improved the 5-year overall survival(88.7%vs 69.1%)and reduced local tumor progression(22.7%vs 49.0%)compared with radiofrequency ablation alone.Although progression-free survival did not differ significantly between the two treatments,multivariate analysis confirmed a robust survival benefit.These findings support the use of systemic maintenance to eradicate micrometastases after locoregional control and warrant validation in prospective randomized trials.
基金Supported by the National Natural Science Foundation of China,No.82072034。
文摘BACKGROUND No clear guidelines for long-term postoperative maintenance therapy have been established for patients with lung oligometastases from colorectal cancer(CRC)who achieve radiological no evidence of disease after radiofrequency ablation(RFA)treatment.We compared the outcomes of patients with lung oligometa-stases from CRC after RFA plus maintenance capecitabine with RFA alone.AIM To determine whether adding capecitabine to RFA improves prognosis compared with RFA alone.METHODS This multicenter retrospective study included consecutive patients from two tertiary cancer centers treated for pulmonary oligometastases from CRC between 2016 and 2023.Subjects were assigned to RFA plus capecitabine(combined)or RFA alone(only RFA)groups.Primary outcomes included overall survival(OS)and progression-free survival(PFS)survival and the secondary outcome was local tumor progression(LTP).The OS,PFS,and LTP rates were compared between the two groups.In addition,prognostic factors were identified using univariate and multivariate analyses.RESULTS Combination therapy(RFA+capecitabine,n=148)and RFA monotherapy(n=99)were compared in patients with CRC and lung metastases.The median OS was 37.8 months(22.4,50.3),the PFS was 18.7 months(13.0,36.5),and the LTP was 31.5 months(20.0,52.4)in the Only RFA group.The OS increased significantly(P=0.011)and the LTP decreased at all time points(P<0.001)in the combined group.The multivariate cox analysis revealed that combined chemotherapy significantly improved OS,with hazard ratios ranging from 0.29 to 0.35(all P<0.015)after adjusting for demographic,tumor,and treatment-related factors.The risk of death was consistently lower in the combination therapy group compared to RFA monotherapy.CONCLUSION RFA prolongs survival and local control in patients with CRC pulmonary oligometastases.Adjuvant capecitabine increases OS and reduces LTP compared to RFA alone,but PFS did not significantly change.
文摘This study focuses on the management of maintenance hemodialysis(MHD)patients,with a specific emphasis on the practical application effect of the network information management model including its impact on patients’compliance.A network information management model for MHD patients was constructed around three management schemes:“software reminders+follow-up guidance”,“dietary records+self-management reminders”,and“dialysis plan+precise weight management”.These schemes were respectively used to optimize anemia management,control the risk of hyperphosphatemia,and improve toxin clearance efficiency.A controlled experiment was conducted,with an experimental group and a control group set up for comparative practice.The results showed that the network information management model can effectively improve patients’anemia,help alleviate mineral metabolism disorders and the accumulation of small-molecule toxins,and exert a positive impact on patients’treatment compliance.
文摘This paper investigates the selective maintenance o systems that perform multi-mission in succession. Selective maintenance is performed on systems with limited break time to improve the success of the next mission. In general, the duration of the mission is stochastic. However, existing studies rarely take into account system availability and the repairpersons with different skill levels. To solve this problem, a new multi-mission selective maintenance and repairpersons assignment model with stochastic duration of the mission are developed. To maximize the minimum phase-mission reliability while meeting the minimum system availability, the model is transformed into an optimization problem subject to limited maintenance resources. The optimization is then realized using an analytical method based on a self-programming function and a Monte Carlo simulation method, respectively. Finally, the validity of the model and solution method approaches are verified by numerical arithmetic examples. Comparative and sensitivity analyses are made to provide proven recommendations for decision-makers.
基金Jiangxi Meteorological Bureau Project (JXCX202304,JX2024Y01)Geological Disaster Prevention and Control Project of Jiangxi Provincial Department of Natural Resources(B360000030004)+1 种基金Key Research and Development Project of Jiangxi Province (20243BBH81005)Weather Review Project of China Meteorological Administration (FPZJ2025-066)。
文摘The “3·31” severe squall line event in eastern China was notable for its exceptional intensity and persistence,posing significant challenges to forecast accuracy. This study analyzed the maintenance stage of this event using highresolution convection-permitting numerical simulations, with a focus on vorticity budgets of the environmental flow, multiscale synoptic diagnostics, and Rotunno-Klemp-Weisman(RKW) theory. These analyses aimed to elucidate the mechanisms governing the morphological transition, the generation of associated convective gales, and the prolonged maintenance of the squall line event. The results show that the numerical simulation accurately reproduced the development and evolution of the squall line, particularly its location, with surface wind errors remaining within a reasonable range. The development of a mesoscale vortex modulated the dynamic and water vapor fields, providing favorable mesoscale environmental conditions for the organization and maintenance of the squall line. Vorticity budget analysis indicates that the divergence and tilting terms were the primary contributors to vorticity tendency. After the squall line entered Jiangxi Province, it exhibited a sharper leading edge and enhanced upward motion. Dry intrusion from the mid-toupper troposphere led to rapid downward momentum transfer at the meso-γ scale, thereby generating convective gales. In addition, the enhancement of the rear-inflow jet(RIJ) was related to the pressure difference between the interior and exterior of system, which resulted from the phase change of condensate within tilted updrafts. The RIJ was orthogonal to the squall line, causing it to transform from a linear into a bowing shape. Diagnosis based on the RKW theory underscore the important roles in both low-level and deep vertical wind shear in maintenaning the squall line. The ratios of the cold pool propagation velocity to the vertical wind shear were close to 1, which balanced with the ambient horizontal vorticity that allowed the convection to remain upright, thus sustaining the squall line's intensity for an extended period. In summary, the squall line event was sustained by a favorable environment created by the environmental vortex. The dry intrusion from the mid-to-upper troposphere and intensified RIJ resulted in the severe convective winds, while the balance between cold pool and ambient vertical wind shear promoted the system's prolonged maintenance. These findings provide an effective reference for the short-range forecasting of squall lines throughout their lifecycle.
