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MAINTAINABLE MECHANISM OF MESO-β SCALE CONVECTIVE SYSTEM 被引量:1
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作者 彭加毅 伍荣生 王元 《Acta meteorologica Sinica》 SCIE 2002年第4期405-422,共18页
By means of the Penn State-NCAR Mesoscale Model Version 5(MM5)with a horizontal resolution of 20 km.the maintainable mechanism of Meso-β scale Convective System(Mβ CS)has been investigated on the basis of simulation... By means of the Penn State-NCAR Mesoscale Model Version 5(MM5)with a horizontal resolution of 20 km.the maintainable mechanism of Meso-β scale Convective System(Mβ CS)has been investigated on the basis of simulation of the temporal and spatial thermodynamics structure of the MβCS which occurred in Wuhan and its surroundings on 21 July 1998.The occurrence of the significant warm-core in the center of the MβCS happened in Changjiang River Basin between the Mufu Mountain and the Dabie Mountain.To the southern side of the MβCS,there exist the southwest low-level jet(LLJ)and the vertical secondary circulation in the low and middle troposphere respectively.In respect to the northern of the MβCS,the northwest jet emerges in the upper troposphere,accompanied with cold and dry atmosphere downdrafts,resulting in another secondary circulation.The foregoing mentioned vertical wind shear provides a favorable dynamical environment for the intensification and maintenance of the MβCS.Equally important,the latent heat release associated with the MβCS produces the warm center in the middle troposphere and the pressure falls.The pressure drop then accelerates air parcels toward the low leading to strong convergence as well as the intensified convection,establishing a positive feedback between the convection and the latent heat release,which is the thermodynamic mechanism of the development and maintenance of the MβCS. 展开更多
关键词 meso-β scale convective system(MβCS) warm center structure maintainable mechanism
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Cell therapy rejuvenates the neuroglial-vascular unit
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作者 Bandy Chen 《Neural Regeneration Research》 2026年第4期1542-1543,共2页
The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. Th... The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. The brain is made up of a complex network of different cell types that work in tandem to maintain systemic homeostasis. 展开更多
关键词 maintain systemic homeostasis prevent treat neurodegeneration cell therapy neurological disorders neuroglial vascular unit network different cell types NEURODEGENERATION aging population
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Specific dendritic spine modifications and dendritic transport:From in vitro to in vivo
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作者 Albert H.K.Fok Charlotte H.M.Lam Cora S.W.Lai 《Neural Regeneration Research》 2026年第2期665-666,共2页
Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for sign... Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for signal transduction.The plasticity of spine morphologies provides a tunable handle to regulate calcium signal dynamics,allowing rapid regulation of protein expression necessary to establish and maintain synapses(Cornejo et al.,2022).If excitatory inputs were to be located primarily on dendritic shafts,dendrites would frequently short-circuit,preventing voltage signals from propagating(Cornejo et al.,2022).It is thus not surprising that the structural plasticity of dendritic spines is closely linked to synaptic plasticity and memory formation(Berry and Nedivi,2017).While comprehensive in vitro studies have been conducted,in vivo studies that directly tackle the mechanism of dendritic transport and translation in regulating spine plasticity spatiotemporally are limited. 展开更多
关键词 excitatory synapses principal neuronsplaying compartmentalized environment establish maintain synapses cornejo dendritic spines regulate calcium signal dynamicsallowing regulation protein expression dendritic shaft
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面向实战的装备系统RMS综合仿真验证技术
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作者 张悦 张文良 +3 位作者 冯强 郭星 任羿 王自力 《系统仿真学报》 北大核心 2025年第7期1823-1835,共13页
针对现有装备系统的可靠性、维修性和保障性(reliability maintainability supportability,RMS)仿真验证通常基于典型条件开展,存在实战环境和任务建模能力弱的问题,提出了一种基于多智能体的RMS仿真验证框架。突破了复杂环境与多变任... 针对现有装备系统的可靠性、维修性和保障性(reliability maintainability supportability,RMS)仿真验证通常基于典型条件开展,存在实战环境和任务建模能力弱的问题,提出了一种基于多智能体的RMS仿真验证框架。突破了复杂环境与多变任务的智能体建模技术,构建了环境类智能体、任务类智能体与装备及保障系统的交互机制,给出了基于仿真的RMS综合评价方法。案例验证表明:所提出的RMS综合仿真验证方法能够实现复杂环境与多变任务建模,支持完成面向实战的仿真验证与设计方案综合评价,满足实战化研制需求。 展开更多
关键词 RMS(reliability maintainability supportability) 多智能体 仿真验证 复杂环境 多变任务
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Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis 被引量:1
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作者 Zhenyu Zhang Lulu Liu +12 位作者 Huibo Ti Minnan Chen Yuechun Chen Deyan Du Wenjing Zhan Tongtong Wang Xian Wu Junjie Wu Dong Mao Zhengdong Yuan Jingjing Ruan Genxiang Rong Feng-lai Yuan 《Bone Research》 2025年第4期968-986,共19页
Rheumatoid arthritis(RA)is a systemic autoimmune disease in which synovial fibroblasts(SFs)maintain chronic inflammation by secreting proinflammatory mediators,leading to joint destruction.While the role of proinflamm... Rheumatoid arthritis(RA)is a systemic autoimmune disease in which synovial fibroblasts(SFs)maintain chronic inflammation by secreting proinflammatory mediators,leading to joint destruction.While the role of proinflammatory mediators in this process is well-established,the contribution of non-inflammatory regulators in SFs to joint pathology remains poorly understood.In this study,we investigated the non-inflammatory role of SFs in RA using a co-culture model,and found that SFs from RA patients promote apoptosis of human chondrocytes.Mechanistic investigations reveal that SFs can secrete small extracellular vesicles(sEVs),which are taken up by chondrocytes and induce chondrocyte apoptosis in both normal chondrocytes and chondrocytes from patients with RA.sEV-derived miRNA 15-29148 are identified as key signaling molecules mediating the apoptosis effects of chondrocytes.Further studies reveal that SF-derived miRNA 15-29148 targeting CIAPIN1 results in increased chondrocyte apoptosis.We further demonstrate that SF-derived miRNA 15-29148 is transferred to chondrocytes,exacerbating cartilage damage in vivo.Moreover,chondrocyte-specific aptamer-modified polyamidoamine nanoparticles not only ameliorated RA but also prevented its onset.This study suggests that,in RA,the secretion of specific sEV-miRNAs from SFs plays a crucial role in promoting chondrocyte apoptosis,potentially through non-inflammatory regulation,and that sEV-miRNA inhibition in SFs may represent an early preventive treatment strategy for cartilage degradation in RA. 展开更多
关键词 Rheumatoid Arthritis rheumatoid arthritis ra Small Extracellular Vesicles miR proinflammatory mediators Synovial Fibroblasts synovial fibroblasts sfs maintain systemic autoimmune disease
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Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state
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作者 Elena Ambrosini Angela Lanciotti Maria Stefania Brignone 《Neural Regeneration Research》 SCIE CAS 2025年第7期2008-2010,共3页
Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental... Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult life.To maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner. 展开更多
关键词 alterations MODULATOR MAINTAIN
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Apolipoprotein E elicits targetdirected miRNA degradation to maintain neuronal integrity
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作者 Jiazi Tan Chin-Tong Ong 《Neural Regeneration Research》 SCIE CAS 2025年第9期2577-2578,共2页
Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous system.There are three predominant human ApoE pr... Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous system.There are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158. 展开更多
关键词 METABOLISM GLYCOPROTEIN MAINTAIN
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The Stage Set for 2025
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作者 Zhang Hui 《China Today》 2025年第1期2-2,共1页
As 2024 comes to an end,the pickup in consumption and robust growth in a range of sectors have bolstered confidence that the Chinese economy is right on track to meet the preset growth rate of around five percent.Bene... As 2024 comes to an end,the pickup in consumption and robust growth in a range of sectors have bolstered confidence that the Chinese economy is right on track to meet the preset growth rate of around five percent.Benefiting from a flurry of consumption-stimulating policies and measures,China’s online retail sales surpassed RMB 14 trillion in the January-November period,a year-on-year increase of 7.4 percent.Imports and exports maintained steady growth,climbing by 4.9 percent year-on-year in renminbi terms.Value-added industrial output also expanded 5.8 percent year-on-year.The volume of express delivery parcels reached a new high of 150 billion and is expected to grow higher still given the new-year festivities ahead. 展开更多
关键词 maintained expanded measures
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Positive mindset,bright future
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作者 李玉莲 《疯狂英语(新读写)》 2025年第8期71-72,80,共3页
In life,we are bound to encounter various difficulties and setbacks.However,it is of great significance to maintain a positive attitude when were facing these challenges.For me,this lesson was deeply impressed upon me... In life,we are bound to encounter various difficulties and setbacks.However,it is of great significance to maintain a positive attitude when were facing these challenges.For me,this lesson was deeply impressed upon me during a particularly tough period. 展开更多
关键词 bright future maintaining positivity DIFFICULTIES challenging period setbacks positive mindset
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A Chinese Festival for the World
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《ChinAfrica》 2025年第2期2-2,共1页
If you are to choose an event that can best represent China’s culture,undoubtedly,it will be the Spring Festival,or the Chinese Lunar New Year.It is a cherished occasion for families to get together,extend best wishe... If you are to choose an event that can best represent China’s culture,undoubtedly,it will be the Spring Festival,or the Chinese Lunar New Year.It is a cherished occasion for families to get together,extend best wishes to the people around them,and maintain friendships. 展开更多
关键词 DOUBT MAINTAIN CULTURE
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CHINA’S ECONOMIC OUTLOOK FOR 2025 The economic impact of tariff issues should be addressed properly
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作者 Dr.Tharakorn Wusatirakul 《China Report ASEAN》 2025年第2期76-77,共2页
China’s economy is expected to remain stable throughout 2025.According to projections by the Center for Forecasting Science of the Academy of Mathematics and Systems Science under the Chinese Academy of Sciences,Chin... China’s economy is expected to remain stable throughout 2025.According to projections by the Center for Forecasting Science of the Academy of Mathematics and Systems Science under the Chinese Academy of Sciences,China’s GDP(gross domestic product)growth should settle at around 4.8 percent this year and will likely hit 5 percent if the government’s stimulus package is effectively implemented.I personally believe that the Chinese economy will maintain growth of about 4.6 percent in 2025 with robust performance in the first and fourth quarters and slower economic activity in the second and third quarters. 展开更多
关键词 PROPERLY MAINTAIN LIKELY
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CHARTING STEADY GROWTH Proactive policies and innovation will drive China’s economic stability in 2025
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作者 He Weiwen 《China Report ASEAN》 2025年第1期60-61,共2页
The annual Central Economic Work Conference 2024,held on December 11-12,set the overall goal and policy framework for Chinese economy in 2025,a crucial year in China’s economic development as the final year of the 14... The annual Central Economic Work Conference 2024,held on December 11-12,set the overall goal and policy framework for Chinese economy in 2025,a crucial year in China’s economic development as the final year of the 14th Five-Year Plan(FYP)and the preparation for the 15th FYP.A series of incremental fiscal and monetary policies adopted since the end of September has seen their initial effects in stabilizing stock markets and boosting consumption and production and thus enhanced the confidence of meeting the GDP goal for 2024.In the face of complicated external challenges and domestic difficulties-inadequate effective demand,overcapacity in some sectors and weak expectations,it is crucial to maintain stable growth in 2025.The Central Economic Work Conference 2024 set the general goal of 2025 on maintaining stable growth,employment and consumer prices. 展开更多
关键词 MAINTAIN BOOSTING policy
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Forging Partners in Development
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《ChinAfrica》 2025年第1期2-2,共1页
China-Africa relations maintained their upward trajectory in 2024,with new plans for future cooperation taking shape.Chinese President Xi Jinping described the China-Africa partnership as being at its best in history.... China-Africa relations maintained their upward trajectory in 2024,with new plans for future cooperation taking shape.Chinese President Xi Jinping described the China-Africa partnership as being at its best in history.The Beijing Summit of the Forum on China-Africa Cooperation(FOCAC),held in September 2024,elevated bilateral ties between China and African countries with diplomatic relations with China to a strategic level.It also redefined China-Africa relations as an“all-weather China-Africa community with a shared future for the new era.”This signifies that China and Africa will remain steadfast friends and close development partners,regardless of changes in the international landscape. 展开更多
关键词 AFRICA maintained PARTNER
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Resilience in nursing research:current status and future prospects
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作者 An-Ni Wang 《Nursing Communications》 2025年第7期1-2,共2页
Resilience has emerged as a critical concept in nursing research,offering a lens through which to understand how individuals,families,and communities navigate adversity,maintain well-being,and thrive in the face of ch... Resilience has emerged as a critical concept in nursing research,offering a lens through which to understand how individuals,families,and communities navigate adversity,maintain well-being,and thrive in the face of challenges[1].As healthcare systems worldwide grapple with increasing demands,workforce shortages,and the lingering effects of global crises such as the COVID-19 pandemic,the study of resilience has never been more relevant.This editorial explores the current status of resilience in nursing research,focusing on individual,family,and social-ecological resilience,while also considering future directions for this vital field. 展开更多
关键词 NURSING offering MAINTAIN
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Harnessing the Power of Collaboration China,Zimbabwe celebrate 45 years of fruitful partnership,aiming to expand cooperation across all areas
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《ChinAfrica》 2025年第4期35-37,共3页
The year 2025 marks the 45th anniversary of the establishment of diplomatic relations between China and Zimbabwe.During this period,China-Zimbabwe economic cooperation has deepened,especially in the fields of infrastr... The year 2025 marks the 45th anniversary of the establishment of diplomatic relations between China and Zimbabwe.During this period,China-Zimbabwe economic cooperation has deepened,especially in the fields of infrastructure construction,mineral resource development,and agriculture.The two sides have maintained a high degree of political mutual trust and have cooperated closely in international affairs.Cultural exchanges and people-to-people contacts have expanded,and both nations continue to work together to further deepen their partnership. 展开更多
关键词 mutual maintained expanded
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Reviewer Acknowledgements
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《International Journal of Ophthalmology(English edition)》 2025年第1期193-198,共6页
The editors of International Journal of Ophthalmology gratefully acknowledge the members of IJO Editorial Board and reviewers from 54 countries and regions who participated in the peer-reviews and provided their valua... The editors of International Journal of Ophthalmology gratefully acknowledge the members of IJO Editorial Board and reviewers from 54 countries and regions who participated in the peer-reviews and provided their valuable comments between Nov.1st,2023 and Oct.31st,2024.They volunteer their valuable time and expertise,and without them we would not maintain the necessary quality expected of the journal.We apologize if we have inadvertently missed a reviewer’s name off this list. 展开更多
关键词 JOURNAL KNOWLEDGE MAINTAIN
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Unlocking the elasticity in ferroelectrics by slight crosslinking
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作者 Fangzhou Li Liang Gao +1 位作者 Linping Wang Ben-Lin Hu 《Chinese Journal of Structural Chemistry》 2025年第3期15-17,共3页
Elastic electronics are increasingly prevalent in information storage,smart sensing and health monitoring due to their softness,stretchability and portability.Wearable electronic devices should possess elasticity and ... Elastic electronics are increasingly prevalent in information storage,smart sensing and health monitoring due to their softness,stretchability and portability.Wearable electronic devices should possess elasticity and stretchability that align with biological tissues.Specifically,their materials should be capable of elastic strain up to 50–80%,while the devices themselves must maintain electric stability under strains that accommodate body movements[1]. 展开更多
关键词 biological tissuesspecificallytheir maintain electric stability FERROELECTRICS health monitoring ELASTICITY information storagesmart sensing elastic electronics CROSSLINKING
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EXCHANGE CENTER STAGE The past decade brought increasingly frequent China-Vietnam theatrical exchanges through multiple channels
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作者 Peng Shituan 《China Report ASEAN》 2025年第1期24-26,共3页
China and Vietnam have maintained close theatrical exchange.A group of Vietnamese students studied at the Central Academy of Drama and the National Academy of Chinese Theatre Arts(NACTA)of China in the 1950s and’60s.... China and Vietnam have maintained close theatrical exchange.A group of Vietnamese students studied at the Central Academy of Drama and the National Academy of Chinese Theatre Arts(NACTA)of China in the 1950s and’60s.The past decade has witnessed steadily improving relations between the two countries.Their cultural exchange,especially in theatrical arts,has become increasingly fruitful in three distinct ways. 展开更多
关键词 maintained VIETNAM frequent
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RULES,RESILIENCE,AND SHARED GROWTH China-ASEAN cooperation,guided by rules,inclusivity,and strategic pragmatism,aims to strengthen regional stability,shared growth,and mutual trust amid global uncertainties
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作者 Antony Hardi 《China Report ASEAN》 2025年第11期40-41,共2页
As the geopolitical and economic landscape of the Asia-Pacific continues to evolve,the partnership between China and ASEAN has reached a defining juncture.The dual imperatives of maintaining strategic autonomy while d... As the geopolitical and economic landscape of the Asia-Pacific continues to evolve,the partnership between China and ASEAN has reached a defining juncture.The dual imperatives of maintaining strategic autonomy while deepening economic interdependence have pushed regional actors to refine their approaches to cooperation.Among them,Singapore and Thailand o"er two distinct yet complementary perspectives on how Southeast Asia can sustain stability,inclusivity,and shared growth amid intensifying global uncertainties. 展开更多
关键词 thailand maintaining strategic autonomy china asean cooperation southeast asia RULES deepening economic interdependence geopolitical RESILIENCE
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Strengthening flyway conservation through NGOs'engagement:Case of Hanns Seidel foundation
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作者 Hyun-Ah Choi Bernhard Seliger 《Avian Research》 2025年第4期650-652,共3页
1.Need for coordinated flyways conservation Flyways are migratory routes that encompass breeding,stopover,and non-breeding habitats essential for the annual life cycles of migratory birds(Bamford et al.,2008;Newton,20... 1.Need for coordinated flyways conservation Flyways are migratory routes that encompass breeding,stopover,and non-breeding habitats essential for the annual life cycles of migratory birds(Bamford et al.,2008;Newton,2023).These routes are critical for maintaining global biodiversity by supporting seasonal movements across continents(Hua et al.,2015;Runge et al.,2015).Effective conservation of flyways,such as the East Asian-Australasian Flyway(EAAF)and Central Asian Flyway(CAF),requires international cooperation to protect key stopover sites(Yong et al.,2015;Kumar 2019;Schmaljohann et al.,2022). 展开更多
关键词 coordinated conservation BIODIVERSITY seasonal movements maintaining global biodiversity flyways conservation international cooperation migratory routes migratory birds bamford
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