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Study on the damage mechanism of high chromia refractory in the slag ta
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作者 PENG Baozi LIU Zhen +4 位作者 BAI Jin LI Huaizhu SUN Kaidi AN Haiquan LI Jun 《燃料化学学报(中英文)》 北大核心 2026年第3期170-179,共10页
The service life of refractory brick in the slag tapping hole of gasifiers is a significant concern for long-term and stable operation.This study examined the damage mechanism of high chromia refractory of four commer... The service life of refractory brick in the slag tapping hole of gasifiers is a significant concern for long-term and stable operation.This study examined the damage mechanism of high chromia refractory of four commercial coal-water slurry gasifiers with their corresponding gasification coal samples and the corroded refractory bricks in the slag tapping hole of the gasifier.The slag characteristic,including crystallization and viscosity-temperature of four gasification coal samples were analyzed.The results revealed that the low viscosity slag could lead to more severe damage to refractory bricks.Given the risk of slag crystallization,it is recommended to establish a safe slag tapping temperature range should be set as tICT(initial crystallization temperature)−t_(2.5) when tICT is higher than t_(25).Upon examining interior morphology of these corroded refractory bricks,some cracks were observed within them.The chemical composition of molten slag was analyzed using SEM-EDS.However,XRD results found no spinel containing zirconium in these cracks.This suggests that the emergence of these cracks are mainly attributed to the molten slag penetration and the subsequent reaction with the refractory material.The difference in thermal expansion between the newly formed substances and refractory material is critical in forming these cracks.Furthermore,SEM-EDS analysis was also conducted on the slag-aggregate and the slag-matrix interface.The results reveal that the reduction in Cr_(2)O_(3) content is the earliest characteristic of damage in high chromia refractories.A proposed damage mechanism of refractory brick suggests that the matrix and aggregate of high chromia refractory are initially compromised because of the reduced Cr_(2)O_(3) content.Subsequently,the molten slag penetrates the interior of the refractory brick,forming new substances,leading to damage caused by the difference in thermal expansion between the new substances and the refractory brick.Understanding and preventing the reduction of Cr_(2)O_(3) content is vital to prolonging the service life of refractory brick in the slag tapping hole of the gasifier based on this damage mechanism. 展开更多
关键词 GASIFICATION high chromia refractory SLAG damage mechanism corrosion
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Time-dependent behavior of deep roadway surrounding rock considering damage induced by excavation and mining disturbances:Experiments,modeling,and simulation
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作者 Qingzhe Cui Rongbin Hou +4 位作者 Zhenhua Li Feng Du Xu Chen Boyang Zhang Lielie Li 《International Journal of Mining Science and Technology》 2026年第2期439-456,共18页
In deep coal mining,surrounding rock is subjected to both high in-situ stress and intense mining disturbances,leading to significant time-dependent behavior.Accurately capturing this behavior is essential for predicti... In deep coal mining,surrounding rock is subjected to both high in-situ stress and intense mining disturbances,leading to significant time-dependent behavior.Accurately capturing this behavior is essential for predicting long-term roadway stability,necessitating the development of a reliable constitutive creep model and numerical simulation approach.In this study,creep experiments were conducted on pre-damaged rock with varying initial damage levels to investigate the time-dependent mechanical properties.Based on the experimental results,an accelerated-creep criterion was proposed,and an elastic-viscoplastic creep damage model(EVPCD)was established that simultaneously considers the effects of time-dependent damage and instantaneous damage caused by stress disturbances on rock creep behavior.Subsequently,the effectiveness of the proposed creep model was verified using experimental data,and the secondary development of the EVPCD model was completed based on the FLAC3D platform.Following this,a long-term stability analysis method of deep surrounding rock that accounts for excavation-and mining-induced disturbances was proposed.Using the main roadway of Xutuan Coal Mine as a case study,numerical simulations were carried out to investigate the time-dependent deformation and failure characteristics of the surrounding rock following excavation and mining disturbance.Combined with on-site monitoring of the surrounding rock damage areas,the results indicate that the EVPCD outperforms the CVISC and Nishihara models in predicting the time-dependent behavior of deep surrounding rock. 展开更多
关键词 Initial damage Time-dependent damage Creep model Numerical implementation damage evolution
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Damage evolution and constitutive model of limestone with horizontal fissure under the coupled effects of dry-wet cycling and precompression stress
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作者 Shunbo Zhang Zhongping Yang +2 位作者 Yang Gao Miao Liu Shanmeng Hou 《International Journal of Mining Science and Technology》 2026年第1期205-228,共24页
To reveal the influence of coupled effects of dry-wet cycling and precompression stress(CEDWCPS)on the damage evolution of limestone with horizontal fissure(LHF),a series of degradation and uniaxial compression tests ... To reveal the influence of coupled effects of dry-wet cycling and precompression stress(CEDWCPS)on the damage evolution of limestone with horizontal fissure(LHF),a series of degradation and uniaxial compression tests were conducted,and a corresponding piecewise damage constitutive model(PDCM)was established.We found that both dry-wet cycling and precompression stress deteriorate the physical properties,alter the microscopic characteristics,and reduce the mechanical properties of the LHF.These degradations are particularly pronounced under the CEDWCPS,although the magnitude of these changes gradually diminishes with the progression of dry-wet cycling.Meanwhile,they also reduce the deformation degree,prolong the micropore compaction stage,shorten the unstable crack propagation stage,lower the frequency and intensity of AE events,decrease the high-amplitude and high-frequency AE signals,enlarge crack scales,and shorten the crack initiation time.Among the changes of these indicators,the dry-wet cycling plays a dominant role.The crack types of LHF under the CEDWCPS(LHFCEDWCPS)are predominantly tensile cracks,supplemented by shear cracks.The failure mode can be defined as tensileshear composite failure.Finally,the established PDCM effectively captures the nonlinear deformation of micropore and the linear deformation of the matrix in LHFCEDWCPS,with all corresponding R^(2) consistently exceeding 0.97. 展开更多
关键词 Dry-wet cycling Precompression stress Coupled effect Fractured limestone damage evolution damage constitutive model
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Creep properties and acoustic emission characteristics of soft-hard interbedded rock masses with different initial damage
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作者 MIAO Shuai-sheng SU Li-jun +2 位作者 ZHANG Chong-lei PAN Yong-liang TIAN Hong-yan 《Journal of Central South University》 2026年第1期276-298,共23页
To investigate the long-term stability of soft-hard interbedded rock masses with initial damage induced by earthquakes and periodic drying and wetting,this study prepared samples with different initial damage through ... To investigate the long-term stability of soft-hard interbedded rock masses with initial damage induced by earthquakes and periodic drying and wetting,this study prepared samples with different initial damage through cyclic loading and unloading(CLU)experiments followed by cyclic drying and wetting(CDW)experiments,and finally conducted creep experiments.The study analyzed the effects of initial damage on creep mechanical behavior,crack evolution,and explored failure precursor information,revealing the damage failure mechanisms.The results show that the structural characteristics of the rock mass control its macroscopic failure mode.Initial damage promotes microcrack development,influences the fracture mode,and increases the proportion of high-frequency(200−280 kHz)acoustic emission events during creep.Meanwhile,initial damage exacerbates creep characteristics,increasing the creep rate,shortening total creep failure time,and reducing long-term strength.The damage failure is attributed to:the generation of internal cracks and pores in the rock caused by CLU;mineral hydrolysis and expansion-contraction due to CDW,resulting in weakened intergranular cementation;and full development of cracks and pores under creep stress.Additionally,the deformation difference coefficient and the coefficient of variation of RA/AF values can serve as precursor indicators for creep failure. 展开更多
关键词 creep properties initial damage soft-hard interbedded rock mass acoustic emission failure precursors damage failure mechanism
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The combination of Astragali Radix and Anemarrhenae Rhizoma in the treatment of ultraviolet skin damage by regulating the PI3K-AKT pathway
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作者 Jin-Sui He Jia-Yan Lin +6 位作者 Ding-Kang Sun Yi-Fan Zhao Pan Yang Li-Sha Ma Chun-Yan Diao Xue-Ying Liu Qing-Wei Wang 《Traditional Medicine Research》 2026年第3期1-11,共11页
Background:Human skin is affected by ultraviolet rays on a daily basis,and excessive ultraviolet radiation(UVR)can lead to sunburn erythema,tanning,photoaging,and skin tumors.The combination of Astragali Radix(AR)and ... Background:Human skin is affected by ultraviolet rays on a daily basis,and excessive ultraviolet radiation(UVR)can lead to sunburn erythema,tanning,photoaging,and skin tumors.The combination of Astragali Radix(AR)and Anemarrhenae Rhizoma(AAR)is a common pairing in traditional Chinese medicine(TCM).According to earlier studies,they possess properties capable of alleviating the adverse impacts of UVR on the skin.However,the specific actions and underlying mechanisms require further investigation.The study aims to analyze the efficacy of AR-AAR in preventing UVR-induced skin damage and to clarify the associated molecular mechanisms.Methods:Potential signaling pathways by which AR and AAR may protect against UVR-induced skin damage were identified with network pharmacology,molecular docking techniques and molecular dynamics(MD)simulation.Except the normal group,the back skin of SD rats was exposed to 1.1 mW/cm^(2) UVA combined with 0.1 mW/cm^(2) UVB daily,and the UVR skin damage model was established.Morphological features of skin tissues of different groups were discovered through Hematoxylin and Eosin(HE)staining,Masson staining,Weigert staining.ELISA was utilized to measure the levels of reactive oxygen species(ROS),Interleukin 6(IL-6),Interleukin 1β(IL-1β)and Tumor necrosis factos-α(TNF-α)in skin tissues.RT-PCR and Western blot were employed to quantify the mRNA and protein contents of PI3K,AKT,and MMP-9.Results:Network pharmacology analysis predicts that AR-AAR may improve skin damage induced by UVR through the PI3K/AKT signaling pathway.Histological staining shows that AR-AAR can significantly reduce inflammatory infiltration and fibrosis in damaged skin.Treatment with AR-AAR(2:1)significantly reduced the expression levels of IL-1β,IL-6,TNF-αand ROS in UVR-damaged rat skin.After treatment with AR-AAR(2:1),not only did the relative mRNA expression levels of PI3K and AKT and the protein expression levels of PI3K,AKT,P-PI3K,and P-AKT increase,but the mRNA and protein expression levels of MMP-9 decreased.Conclusion:The study indicate that the AR-AAR combination and its active components may mitigate UVR skin damage by modulating the PI3K/AKT signaling pathway. 展开更多
关键词 Astragali Radix Anemarrhenae Rhizoma COMBINATION ULTRAVIOLET skin damage
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Atomistic Simulation Study on Spall Failure and Damage Evolution in Single-Crystalline Ta at Elevated Temperatures
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作者 Yuntian Wang Taohua Liang +3 位作者 Yuan Zhou Weimei Shi Lijuan Huang Yuzhu Guo 《Computers, Materials & Continua》 2026年第2期355-380,共26页
This investigation utilizes non-equilibrium molecular dynamics(NEMD)simulations to explore shockinduced spallation in single-crystal tantalumacross shock velocities of 0.75–4 km/s and initial temperatures from300 to ... This investigation utilizes non-equilibrium molecular dynamics(NEMD)simulations to explore shockinduced spallation in single-crystal tantalumacross shock velocities of 0.75–4 km/s and initial temperatures from300 to 2000 K.Two spallation modes emerge:classical spallation for shock velocity below 1.5 km/s,with solid-state reversible Body-Centered Cubic(BCC)to Face-Centered Cubic(FCC)orHexagonal Close-Packed(HCP)phase transformations and discrete void nucleation-coalescence;micro-spallation for shock velocity above 3.0 km/s,featuring complete shock-induced melting and fragmentation,with a transitional regime(2.0-2.5 km/s)of partial melting.Spall strength decreases monotonically with temperature due to thermal softening.Elevated temperatures delay void nucleation but increase density,expanding spall regions and enhancing structural disorder with reduced BCC recovery.For microspallation,melting exacerbates damage,causing smaller voids and intensified atomic ejection,which increases with temperature.Free surface velocity profiles indicate damage:in classical spallation,first drop marks nucleation,and pullback signals spall layers.In micro-spallation,the first drop is irrelevant,but remains valid.Temperature delays pullback signals and weakens Hugoniot Elastic Limit.This study clarifies temperature-shock coupling in Ta spallation,aiding failure prediction in high-temperature shock environments. 展开更多
关键词 Single-crystal tantalum temperature effect shock-induced spallation damage evolution
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Deep learning-based method for damage identification and localization of the maglev track stator surface
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作者 Shihua Huang Tiange Wang Guofeng Zeng 《High-Speed Railway》 2026年第1期21-26,共6页
The stator of the maglev track plays a crucial role in the operation of the maglev system.Currently,the efficiency of maglev track inspection is limited by several factors,including the large span of elevated structur... The stator of the maglev track plays a crucial role in the operation of the maglev system.Currently,the efficiency of maglev track inspection is limited by several factors,including the large span of elevated structures,manual visual inspection,short inspection window times,and limited GPS positioning accuracy.To address these issues,this paper proposes a deep learning-based method for detecting and locating stator surface damage.This study establishes a maglev track stator surface image dataset,trains different object detection models,and compares their performance.Ultimately,YOLO and ByteTrack object tracking algorithms were chosen as the basic framework and enhanced to achieve automatic identification of high-speed maglev track stator surface damage images and track and count stator surface localization feature images.By matching the identified damaged images with their corresponding stator segment and beam segment sequence numbers,the location of the damage is pinpointed to the corresponding stator segment,enabling rapid and accurate identification and localization of complex damage to the maglev track stator surface. 展开更多
关键词 Maglev track damage recognition Precise localization Deep learning TRACKING
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Proposal,Promotion,and Practice and Application of Damage Control Surgery Concept in Trauma Treatment at Grassroots Hospitals
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作者 Jingcheng Chen Yongzhan Chen Jing Xu 《Journal of Clinical and Nursing Research》 2026年第1期366-372,共7页
The concept of Damage Control Surgery(DCS)emphasizes prioritizing hemorrhage control,preventing hypothermia,correcting coagulopathy,and acidosis in trauma treatment.The application of the DCS concept in trauma treatme... The concept of Damage Control Surgery(DCS)emphasizes prioritizing hemorrhage control,preventing hypothermia,correcting coagulopathy,and acidosis in trauma treatment.The application of the DCS concept in trauma treatment at grassroots hospitals faces numerous challenges such as limited resources,high technical difficulty,and insufficient multidisciplinary collaboration.Therefore,DCS strategies need to be adapted to simplified processes to create conditions for subsequent treatment.This paper retrieves relevant literature to discuss the proposal,promotion,and application of the DCS concept,aiming to provide evidence-based basis for optimizing trauma treatment outcomes at grassroots hospitals. 展开更多
关键词 damage control surgery Concept promotion Grassroots hospitals Trauma treatment
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Thermo-mechanical damage behavior of the interface between hybrid alkali-resistant glass fiber-reinforced concrete and rock under high and variable temperature conditions
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作者 Cong Zhang Zhen Xu +4 位作者 Shanyong Wang Chong Shi Hui Wang Yonggang Zhang Guoqing Chen 《International Journal of Mining Science and Technology》 2026年第2期399-421,共23页
Thermal-mechanical damage and deformation at the interface between shotcrete linings and the surrounding rock of tunnels under high-temperature and variable-temperature conditions are critical to the safe construction... Thermal-mechanical damage and deformation at the interface between shotcrete linings and the surrounding rock of tunnels under high-temperature and variable-temperature conditions are critical to the safe construction and operation of tunnel engineering.This study investigated the thermo-mechanical damage behavior of the composite interface between alkali-resistant glass fiber-reinforced concrete(ARGFRC)and granite,focusing on a plateau railway tunnel.Laboratory triaxial tests,laser scanning,XRD analysis,numerical simulations,and theoretical analyses were employed to investigate how different initial curing temperatures and joint roughness coefficient(JRC)influence interfacial damage behavior.The results indicate that an increase in interface roughness exacerbates the structural damage at the interface.At a JRC of 19.9 and a temperature of 70℃,crack initiation in granite was notably restrained when the confining pressure rose from 7 MPa to 10 MPa.Roughness-induced stress distribution at the interface was notably altered,although this effect became less pronounced under high confining pressure conditions.Additionally,during high-temperature curing,thermal stress concentration at the tips of micro-convex protrusions on the granite surface induced microcracks in the adjacent ARGFRC matrix,followed by deformation.These findings provide practical guidelines for designing concrete support systems to ensure tunnel structural safety in high-altitude regions with harsh thermal environments. 展开更多
关键词 High and variable temperature ARGFRC-granite INTERFACE Thermo-mechanical coupling damage evolution
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Experimental study on damage evolution and failure precursor characteristics of granite under thermal shock cycles
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作者 Zhenjiang Huang Mingxuan Shen +5 位作者 Yu Zhao Chaolin Wang Jing Bi Yongfa Zhang Shuang Dang Yuhang Zhao 《International Journal of Mining Science and Technology》 2026年第1期125-148,共24页
Investigating the damage evolution of surrounding rock under thermal shock cycles is crucial for ensuring the stability of engineering rock masses.This study performed Brazilian splitting tests on granite specimens un... Investigating the damage evolution of surrounding rock under thermal shock cycles is crucial for ensuring the stability of engineering rock masses.This study performed Brazilian splitting tests on granite specimens under varying temperature and cycle conditions,employing acoustic emission monitoring,digital image correlation,and three-dimensional scanning technology.A systematic analysis was conducted on the patterns of damage evolution,failure precursor,and response mechanisms under combined thermal and cyclic loading.Experimental results show that both P-wave velocity and tensile strength degrade significantly with increasing temperature and cycle count,with temperature having a more pronounced effect than cycle count.Notably,damage evolution exhibits a dual-threshold behavior in which degradation accelerates markedly above 400℃ and stabilizes after 5 thermal cycles.Fracture surfaces evolve from initially planar to rugged morphologies,with peak-valley height differences at 600℃ being approximately three times greater than those at 200℃.Furthermore,based on acoustic emission energy entropy analysis,we introduce a novel failure precursor indicator where the sustained increase and critical surge in average entropy serve as reliable early-warning signals for impending rock failure.These findings establish a solid theoretical basis and practical methodology for damage assessment and instability early-warning systems in high-temperature rock engineering. 展开更多
关键词 GRANITE Thermal shock cycles Acoustic emission Thermal damage Failure precursor
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Mechanical behavior and damage constitutive model of silty mudstone under thermo-hydro-mechanical interactions
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作者 ZENG Ling CHENG Hui +6 位作者 SONG Jianping XIONG Jianping ZHANG Hongri CHEN Jingcheng WANG Wenguang LI Youjun LIU Jie 《Journal of Mountain Science》 2026年第1期434-452,共19页
Understanding the deterioration behaviors and mechanisms of rocks under thermo-hydromechanical(THM)interactions is crucial for mitigating slope instability.In this study,the physicomechanical properties of silty mudst... Understanding the deterioration behaviors and mechanisms of rocks under thermo-hydromechanical(THM)interactions is crucial for mitigating slope instability.In this study,the physicomechanical properties of silty mudstone subjected to THM interactions were investigated by triaxial tests.The underlying micro-mechanisms were revealed using microscopic tests.The triaxial test results indicate that the strength parameters of silty mudstone decrease by 89.50%(deformation modulus),78.15%(peak strength),70.58%(cohesion),and 48.65%(friction angle)under 16 THM cycles,a load of 300 kPa,and alternating between 0℃water immersion and 60℃drying.The SEM test results indicate that the deterioration of silty mudstone strength primarily results from hydrothermal-expansion softening and cracking driven by the TLHM interactions.The specimens manifest shear failure under confining pressure exceeding 140 kPa.Furthermore,a new constitutive model considering hydrothermalexpansion strain and non-linear deformation characteristics was developed.The discrepancy between the experimentally measured peak strength and the damage constitutive model prediction remains below 5%.The proposed model is verified to be in satisfactory agreement with the experimental results.The self-designed THM apparatus overcomes the limitations of traditional investigations,enabling simultaneous consideration of thermal,hydraulic,and mechanical interactions. 展开更多
关键词 Silty mudstone THM interactions Mechanical properties damage constitutive model
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Study on chip formation and damage mechanism of micro-drilling nickel-based single crystal superalloy
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作者 Yunguang Zhou Chunxue Zhang +4 位作者 Ji Zou Yize Lu Lianjie Ma Ming Li Yadong Gong 《Chinese Journal of Mechanical Engineering》 2026年第1期199-210,共12页
Nickel-based single-crystal superalloy DD98M is widely used in high-temperature components such as aero-engines and gas turbines.Since it has only one crystal grain,the theory of slip deformation along the grain bound... Nickel-based single-crystal superalloy DD98M is widely used in high-temperature components such as aero-engines and gas turbines.Since it has only one crystal grain,the theory of slip deformation along the grain boundary of polycrystalline material is not suitable for the machining of a single crystal part.Therefore,micro-drilling of nickel-based single crystal superalloy still faces problems such as unclear cutting formation me-chanism and unclear surface/subsurface damage mechanism.In this paper,the formation mechanism and morphological characteristics of chips and burrs were studied by a single-factor experiment,and the plastic deformation rule and damage mechanism were investigated,combined with the changes of subsurface structure and grain type.Finally,the influence of the law and reason of tool wear condition on the hole wall and the drilled subsurface is analyzed.The experimental results indicate that drill chips mainly exhibit three morphologies.Their free surfaces feature a serrated appearance,while the contact surfaces are smooth.The entrance burrs are mainly flanging burrs.With the increase of spindle speed,the burr height decreases from 49.38 to 9.39μm.As the feed speed increases,the burr height increases from 6.50 to 63.87μm.The drilled subsurface can be divided into a white layer region,a plastic deformation region,and the matrix according to the microstructural change.As the depth from the machined surface increases,the degree of plastic deformation of the material decreases,the grain size gradually reduces,and the dislocation density decreases.Stacking fault and twinning mostly occur in the high-plastic deformation region,and recrystallization occurs on the machined surface.As the drilling length increases,the degree of tool wear increases,and the adhesion and ablation area on the hole wall surface increase.Moreover,the thickness of the white layer increases from 0 to 8.75μm,and the thickness of the plastic deformation layer increases from 1.28 to 11.31μm.The study has significant theoretical and practical implications for the efficient and low-damage machining of micro-holes in the nickel-based single crystal superalloy. 展开更多
关键词 Micro-drilling Nickel-based single crystal superalloy Subsurface damage mechanism Tool wear TEM
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Digital twin-driven structural damage monitoring via multilevel Lamb wave enhancement and transfer learning
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作者 Yuan Huang Xinlin Qing 《High-Speed Railway》 2026年第1期27-32,共6页
As structural damage patterns and service environments become more complex,digital twin-based structural health monitoring,with its unique advantages,can compensate for the limitations of data-driven methods regarding... As structural damage patterns and service environments become more complex,digital twin-based structural health monitoring,with its unique advantages,can compensate for the limitations of data-driven methods regarding data dependency and model interpretability.However,it still faces challenges in modeling complexity,simulation accuracy,and discrepancies between real and virtual features.This study proposes a balanced fidelity digital twin for structural damage monitoring based on Lamb wave multilevel feature enhancement and adaptive space interaction.Firstly,multilevel refined features are extracted from few-shot guided wave signals obtained in physical and digital space,and the adversarial synthetic balancing algorithm is proposed for feature enhancement.Additionally,the learning phase of the damage monitoring model based on the feature-mapping convolutional network is driven by virtual samples of readily accessible balanced fidelity in digital space.To reduce the feature distributional difference between the two spaces,an interactive transfer approach is introduced to establish a shared feature digital twin space.Overall,this study provides a feasible technique to enhance the accessibility and generalizability of digital twins for real engineering structures. 展开更多
关键词 Guided wave features Structural digital twin Interactive transfer damage monitoring
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Damage evolution mechanism of notch high-cycle fatigue in Ti-55531 alloy with multilevel lamellar microstructure
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作者 Zhong ZHANG Chao-wen HUANG +4 位作者 Chang-sheng TAN Jiang YANG Ming-pan WAN Fei LIU Song XIANG 《Transactions of Nonferrous Metals Society of China》 2026年第2期470-487,共18页
The interrupted fatigue test method was utilized to investigate the damage evolution mechanism of the notch high-cycle fatigue(NHCF)in Ti-55531 alloy with a multilevel lamellar microstructure.The results reveal that s... The interrupted fatigue test method was utilized to investigate the damage evolution mechanism of the notch high-cycle fatigue(NHCF)in Ti-55531 alloy with a multilevel lamellar microstructure.The results reveal that significant microvoids and microcracks predominantly initiate at α/β interfaces under various notch root radii(R).Notably,even under larger R(0.75 mm),mutual interactions of stacking faults(SFs)−deformation twins,twins−twins,and SFs−SFs are observed.Furthermore,with decreasing R(0.34 and 0.14 mm),the volume fraction of SFs escalates significantly and twins are almost absent.Moreover,activated prismatic slip system decreases with a decrease in Schmidt factor and with the further decrease in R.Finally,strain localization near α/β interfaces contributes to the initiation of fatigue microcracks. 展开更多
关键词 damage mechanism Ti alloy interrupted fatigue crack initiation stacking fault TWIN prismatic slip system
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αionizing particle radiation detection and damage compensation methods for CMOS active pixel sensors
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作者 Shou-Long Xu Cui-Yue Wei +4 位作者 Zhi-Wei Qin Shu-Liang Zou Yong-Chao Han Qing-Yang Wei You-Jun Huang 《Nuclear Science and Techniques》 2026年第4期115-126,共12页
In this study,the mechanism and characteristics of the responseαparticles and the damage caused by them in CMOS active pixel(APS)sensors were investigated.A detection and compensation algorithm for dead pixels caused... In this study,the mechanism and characteristics of the responseαparticles and the damage caused by them in CMOS active pixel(APS)sensors were investigated.A detection and compensation algorithm for dead pixels caused byαparticle ionizing radiation was proposed,and the effects of dead-pixel compensation algorithms were compared and analyzed under different parameter conditions.The experimental results show thatαparticle response signal has highest accuracy at 9 dB gain,with an obvious“target-ring”distribution.With increasing cumulative dose,the CMOS APS pedestal tends to saturation while dead pixels continue increasing.Though some pixel damage recovers through natural annealing,the dead-to-noise ratio increases with irradiation time,reaching 32.54%after 72 h.A hierarchical clustering dead-pixel detection method is proposed,categorizing pixels into two types:those within and outside the response event.A classification compensation strategy combining mean and majority filtering is proposed.This compensation algorithm can address dead-pixel interference without affectingαparticle radiation response data.When iterated multiple times and with integration time exceeding 6.31 ms,the number of dead pixels can be effectively reduced. 展开更多
关键词 CMOS active pixel sensor αparticles Response event Radiation damage Dead-pixel compensation
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Correction to:Engineered Extracellular Vesicles Loaded with MiR‑100-5p Antagonist Selectively Target the Lesioned Region to Promote Recovery from Brain Damage
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作者 Yahong Cheng Chengcheng Gai +8 位作者 Yijing Zhao Tingting Li Yan Song Qian Luo Danqing Xin Zige Jiang Wenqiang Chen Dexiang Liu Zhen Wang 《Neuroscience Bulletin》 2026年第2期490-490,共1页
In this article,the unit of total distance in Fig.2B was misused.In fact,the unit of total distance exported by the system was"pixels".After correction,the data in Fig.2B were not changed.The Fig.2B should h... In this article,the unit of total distance in Fig.2B was misused.In fact,the unit of total distance exported by the system was"pixels".After correction,the data in Fig.2B were not changed.The Fig.2B should have appeared as shown below. 展开更多
关键词 selective targeting engineered extracellular vesicles brain damage recovery mir p antagonist pixel unit
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Next Generation DNA Damage Response Inhibitors:Harnessing Nanocarriers and Tumor Microenvironment for Precision Cancer Therapy
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作者 Abhishikt David Solomon Himanshu Kumar Vats +6 位作者 Shivam Chowdhary Supriya Nandlal Kanoujiya Ajit Prakash Hina Sultana Sabyasachi Mohanty Billy W.Day Tarun Pant 《Oncology Research》 2026年第3期143-204,共62页
Tumor survival,genomic stability,and therapy resistance are dictated by the DNA damage response(DDR).Although poly(ADP-ribose)polymerase(PARP)inhibitors have established the DDR as a therapeutic target,many tumors eva... Tumor survival,genomic stability,and therapy resistance are dictated by the DNA damage response(DDR).Although poly(ADP-ribose)polymerase(PARP)inhibitors have established the DDR as a therapeutic target,many tumors evade first-generation drugs by rewiring their adaptive repair pathways and imposing microenvironmental constraints.This review synthesizes recent discoveries in key DDR pathways,such as PARP,ataxia telangiectasia and Rad3-related kinase(ATR),ataxia telangiectasia mutated kinase(ATM),checkpoint kinase 1(CHK1),WEE1 G2 checkpoint kinase(WEE1),and DNA-dependent protein kinase(DNA-PK),and describes the next-generation inhibitors designed to increase selectivity and circumvent resistance.We also analyze the role of hypoxia,stromal remodeling,inflammatory cytokines,and immune-cell plasticity in the tumor microenvironment in determining DDR dependency and response.Special attention is paid to cGAS-STING,immunogenic signaling via damage-associated molecular patterns(DAMPs),and mechanisms that convert a cold tumor into a hot one.Lastly,we touch upon the new nanocarrier-based delivery approaches that enhance pharmacokinetics,target resistant tumor niches,and expand the possibilities for combinatorics with immunotherapy and radiotherapy.Collectively,these findings provide a guide to the implementation of next-generation DDR inhibitors and nanomedicines to deliver a more accurate,durable,and context-specific cancer therapy. 展开更多
关键词 DNA damage response(DDR) DDR inhibitors(DDRis) tumor microenvironment
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Heavy-ions-induced failure mechanisms and structural damage in SiC MOSFETs under complex irradiation conditions
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作者 Yiping Xiao Chaoming Liu +4 位作者 Jiaming Zhou Le Gao Mingzheng Wang Tianqi Wang and Mingxue Huo 《Chinese Physics B》 2026年第1期599-606,共8页
The failure mechanisms and structural damage of SiC MOSFETs induced by heavy ion irradiation were demonstrated.The findings reveal three degradation modes,depending on the drain voltage.At a relatively low voltage,the... The failure mechanisms and structural damage of SiC MOSFETs induced by heavy ion irradiation were demonstrated.The findings reveal three degradation modes,depending on the drain voltage.At a relatively low voltage,the damage is triggered by the formation and activation of gate latent damage(LDs),with damage concentrated in the gate oxide.The second degradation mode involves permanent leakage current degradation,with damage progressively transitioning from the oxide to the SiC material as the drain voltage escalates.Ultimately,the device undergoes catastrophic burnout above certain voltages,characterized by the lattice temperature reaching the sublimation point of SiC,resulting in surface cavity and complete structural destruction.This paper presents a comprehensive investigation of SiC MOSFETs under heavy ion exposure,providing radiation resistance methods of SiC-based devices for aerospace applications. 展开更多
关键词 heavy ion irradiation silicon carbide(SiC)MOSFETs structural damage failure mechanism
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Seismic damage characteristics and restoration strategies of the Mandalay municipal water supply system following the 2025 M 7.9 Myanmar earthquake
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作者 Yan Peilei Guo Endong +3 位作者 Huang Yong Zhao Zhipeng A Lata Liu Jingyi 《Earthquake Engineering and Engineering Vibration》 2026年第1期13-25,共13页
Following a magnitude M 7.9 earthquake that struck near Mandalay,Myanmar in March 2025,this study investigates the seismic damage inflicted upon the city’s municipal water supply system.The analysis focuses on the fa... Following a magnitude M 7.9 earthquake that struck near Mandalay,Myanmar in March 2025,this study investigates the seismic damage inflicted upon the city’s municipal water supply system.The analysis focuses on the failure characteristics of water facilities and pipelines,examines cross-system cascading effects,and proposes corresponding recovery strategies.The main findings are as follows:(1)The damage to water plant facilities,concentrated in ancillary structures and connections due to insufficient seismic measures,demonstrated significant intensity-dependence.Increased seismic intensity not only aggravated structural damage but also compromised core treatment processes,leading to deteriorated water quality.(2)Within the same seismic intensity zone,high-density polyethylene(HDPE)pipes exhibited a significantly lower damage occurrence rate than ductile iron(DI)pipes,highlighting the material’s substantial influence on seismic performance.Moreover,a strong positive correlation was observed between the overall pipeline network damage and the seismic intensity.The average damage rate in IntensityⅨzones was 6.84 times that of IntensityⅧzones.(3)A cascading failure,initiated by a power outage,led to water supply disruption,loss of emergency response capability,and elevated secondary risks.This strongly coupled cross-system effect resulted in significant spatiotemporal propagation of disaster impacts.(4)The post-earthquake recovery adopted a phased strategy that prioritized critical facilities.Actions involved rapidly restoring the core supply zone with temporary points,reinstating the water plant’s power supply,and deploying targeted technologies for efficient pipeline repair.The outcomes of this study are expected to provide critical support and a valuable reference for developing earthquake-resilient urban water supply systems. 展开更多
关键词 M 7.9 Myanmar earthquake water supply system seismic damage characteristics cross-system cascading failure restoration strategies
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Damage evolution law under unloading confining pressure of cemented backfill based on energy dissipation
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作者 LIU Wei-zhen GONG Bin +3 位作者 NIU Shi-wei WANG Hui-qin LI Hong-rui HU Zhong-jing 《Journal of Central South University》 2026年第1期400-421,共22页
High ground temperature and unloading disturbance have emerged as critical factors impacting the property of cemented gauge-fly ash backfill(CGFB).The characteristics of energy and damage in CGFB were analyzed under c... High ground temperature and unloading disturbance have emerged as critical factors impacting the property of cemented gauge-fly ash backfill(CGFB).The characteristics of energy and damage in CGFB were analyzed under conditions of high ground temperature and unloading by conducting triaxial unloading tests with different initial confining pressures on CGFB that had been cured at various temperatures.Based on dissipative energy,triaxial unloading confining pressure damage constitutive model of CGFB was constructed.It has been demonstrated that the ratio of elastic strain energy in CGFB decreases and the ratio of dissipated energy increases at the end of unloading increases under higher curing temperature.The change in the elastic energy consumption ratio curve of CGFB,which shifts from a gradual increase to a swift rise at a certain"inflection point",can be utilized as a criterion for evaluating the failure of the unloading strength of CGFB.The triaxial unloading damage constitutive model for CGFB divides the damage progression into three distinct phases:initial damage stage,accelerated damage development stage,and rapid damage growth stage.The research findings offer a theoretical foundation for evaluating the extent of damage to CGFB caused by the combined influences of elevated ground temperature and unloading. 展开更多
关键词 curing temperature cemented gangue-fly ash backfill unloading confining pressure dissipated energy damage constitutive model
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