Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability worldwide.Although PTH is often accompanied by neurological disorders,the exact...Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability worldwide.Although PTH is often accompanied by neurological disorders,the exact underlying mechanism remains largely unknown.Identifying potential biomarkers may prompt the diagnosis and development of effective treatments for mTBI-induced PTH.In this study,a mouse model of mTBI-induced PTH was established to investigate its effects on cerebral structure and function during short-term recovery.Results indicated that mice with mTBI-induced PTH exhibited balance deficits during the early post-injury stage.Metabolic kinetics revealed that variations in neurotransmitters were most prominent in the cerebellum,temporal lobe/cortex,and hippocampal regions during the early stages of PTH.Additionally,variations in brain functional activities and connectivity were further detected in the early stage of PTH,particularly in the cerebellum and temporal cortex,suggesting that these regions play central roles in the mechanism underlying PTH.Moreover,our results suggested that GABA and glutamate may serve as potential diagnostic or prognostic biomarkers for PTH.Future studies should explore the specific neural circuits involved in the regulation of PTH by the cerebellum and temporal cortex,with these two regions potentially utilized as targets for non-invasive stimulation in future clinical treatment.展开更多
Sport-related concussion is a common neurological injury that occurs in all levels of athletic participation.Concussions may actually go undiagnosed,as they do not always display outward signs and athletes may fail to...Sport-related concussion is a common neurological injury that occurs in all levels of athletic participation.Concussions may actually go undiagnosed,as they do not always display outward signs and athletes may fail to report symptoms of concussion,either because they do not know the symptoms,or for fear of removal from play.Inappropriate management of concussion can lead to increased risk of subsequent injury.This article outlines various aspects of sport-related concussion management,including preparation/planning,education,evaluation,management,return to play decisions,and long term effects of concussion.Preparation and education are the first steps that must be taken to minimize the potentially negative consequences of concussion.If a concussion is suspected,it must be stressed that the evaluation should include a multifaceted approach,with a physical examination and assessment of signs and symptoms,neurocognition and balance.The management of concussion should include both physical and cognitive rest and factors such as transportation,sleep,work,and academics should be taken into consideration.Return to play following concussion should follow a graduated return to play protocol,with careful monitoring of symptoms.Sports medicine clinicians should stay up to date with information regarding concussion management and take a conservative approach,because there are recent reports of various cumulative effects of multiple concussions.展开更多
In this clinical practice review, the controversies and difficulties managing post concussion symptoms following mild traumatic brain injury are discussed. Based on considerable clinical experience in a designated Con...In this clinical practice review, the controversies and difficulties managing post concussion symptoms following mild traumatic brain injury are discussed. Based on considerable clinical experience in a designated Concussion Clinic, the authors (a neuropsychologist, a psychiatrist, and a neurologist) review relevant literature and issues for clinical practice, particularly with respect to understanding risk factors for and vulnerability to, development of chronic post-concussion symptoms. We contend it is not just the kind of head that matters but also the kind of complications, the kind of outcomes and the kind of management that can influence injury recovery. Given these complexities, a bio-psychosocial conceptualization of chronic post-concussion syndrome is appropriate. Though understanding is still elusive, management should not be biased by physiogenic or psychogenic aetiological theories for management needs to address patient reported outcomes regardless of underpinning aetiology.展开更多
基金supported by the Natural Science Foundation of Guangdong Province,China(2021A1515010897)Discipline Construction Fund of Central People’s Hospital of Zhanjiang(2020A01,2020A02)+1 种基金National Natural Science Foundation of China(31970973,21921004,32271148)Biosecurity Research Project(23SWAQ24)。
文摘Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability worldwide.Although PTH is often accompanied by neurological disorders,the exact underlying mechanism remains largely unknown.Identifying potential biomarkers may prompt the diagnosis and development of effective treatments for mTBI-induced PTH.In this study,a mouse model of mTBI-induced PTH was established to investigate its effects on cerebral structure and function during short-term recovery.Results indicated that mice with mTBI-induced PTH exhibited balance deficits during the early post-injury stage.Metabolic kinetics revealed that variations in neurotransmitters were most prominent in the cerebellum,temporal lobe/cortex,and hippocampal regions during the early stages of PTH.Additionally,variations in brain functional activities and connectivity were further detected in the early stage of PTH,particularly in the cerebellum and temporal cortex,suggesting that these regions play central roles in the mechanism underlying PTH.Moreover,our results suggested that GABA and glutamate may serve as potential diagnostic or prognostic biomarkers for PTH.Future studies should explore the specific neural circuits involved in the regulation of PTH by the cerebellum and temporal cortex,with these two regions potentially utilized as targets for non-invasive stimulation in future clinical treatment.
文摘Sport-related concussion is a common neurological injury that occurs in all levels of athletic participation.Concussions may actually go undiagnosed,as they do not always display outward signs and athletes may fail to report symptoms of concussion,either because they do not know the symptoms,or for fear of removal from play.Inappropriate management of concussion can lead to increased risk of subsequent injury.This article outlines various aspects of sport-related concussion management,including preparation/planning,education,evaluation,management,return to play decisions,and long term effects of concussion.Preparation and education are the first steps that must be taken to minimize the potentially negative consequences of concussion.If a concussion is suspected,it must be stressed that the evaluation should include a multifaceted approach,with a physical examination and assessment of signs and symptoms,neurocognition and balance.The management of concussion should include both physical and cognitive rest and factors such as transportation,sleep,work,and academics should be taken into consideration.Return to play following concussion should follow a graduated return to play protocol,with careful monitoring of symptoms.Sports medicine clinicians should stay up to date with information regarding concussion management and take a conservative approach,because there are recent reports of various cumulative effects of multiple concussions.
文摘In this clinical practice review, the controversies and difficulties managing post concussion symptoms following mild traumatic brain injury are discussed. Based on considerable clinical experience in a designated Concussion Clinic, the authors (a neuropsychologist, a psychiatrist, and a neurologist) review relevant literature and issues for clinical practice, particularly with respect to understanding risk factors for and vulnerability to, development of chronic post-concussion symptoms. We contend it is not just the kind of head that matters but also the kind of complications, the kind of outcomes and the kind of management that can influence injury recovery. Given these complexities, a bio-psychosocial conceptualization of chronic post-concussion syndrome is appropriate. Though understanding is still elusive, management should not be biased by physiogenic or psychogenic aetiological theories for management needs to address patient reported outcomes regardless of underpinning aetiology.
