Primary lymphoepithelioma-like carcinoma in the liver is extremely rare. A few cases of lymphoepithelioma-like cholangiocarcinoma have been reported, but few radiologic features were described. We reviewed 23 cases of...Primary lymphoepithelioma-like carcinoma in the liver is extremely rare. A few cases of lymphoepithelioma-like cholangiocarcinoma have been reported, but few radiologic features were described. We reviewed 23 cases of lymphoepithelioma-like cholangiocarcinoma reported between 1996 and 2014 and describe a rare case of a 35-year-old woman in our hospital who was diagnosed with lymphoepithelioma-like cholangiocarcinoma of the liver and was a hepatitis B carrier. The tumor(1.6 cm) in our patient appeared to be hypoechoic in sonographic images and hypodense in computed tomography(CT) images. In addition, it was homogeneous hypointense in T1-weighted magnetic resonance(MR) images(MRI) and hyperintense in T2-weighted MRI. Dynamic gadolinium-enhanced MRI showed typical image pattern of hepatocellular carcinoma(HCC). The patient underwent a laparoscopic left hepatic lobectomy, and the resected tumor consisted of well-differentiated glandular cells with extensive lymphocytic infiltration that were immunoreactive to CK(AE1/AE3), CD3, and CD20. In addition, the tumor was positive for Epstein-Barr virus-encoded RNA in situ hybridization. Finally, lymphoepithelioma-like cholangiocarcinoma was diagnosed. In previous studies, the incidence is highest among middle-aged people. Most tumors appeared to be hypodense with either hypovascular or hypervascular patterns in CT images. This case report is the first study to address sonography, CT, and MRI observations and delineate pathologic correlations. We suggest that the imaging pattern of lymphoepithelioma-like cholangiocarcinoma, either the typical cholangiocarcinoma pattern or a mimic of HCC, should be considered in the differential lists for HCC.展开更多
To the Editor:Post-transplant lymphoproliferative disorder（PTLD）is a rare and potentially fatal complication occurring after all types of solid organ transplantation.;PTLD accounts for 20%of all de novo post-transpl...To the Editor:Post-transplant lymphoproliferative disorder（PTLD）is a rare and potentially fatal complication occurring after all types of solid organ transplantation.;PTLD accounts for 20%of all de novo post-transplant tumors.;The most important risk factors for PTLD are prolonged intense immunosuppression and Epstein-Barr virus（EBV）展开更多
The purpose of this study is to check the effect ofDiabetes mellitus on DNA repair of peripheral lympho-cytes.With liquid scintillation counting,the valueof lymphocytes unscheduled ~3H-TdR incorporation in-dex in the ...The purpose of this study is to check the effect ofDiabetes mellitus on DNA repair of peripheral lympho-cytes.With liquid scintillation counting,the valueof lymphocytes unscheduled ~3H-TdR incorporation in-dex in the aged patients with diabetes mellitus grou-展开更多
The frequencies of chromosomal aberrationsof the peripheral blood lymphocytes from 40workers chronically exposed to sulphurdioxide (SO2) at a sulphuric acid factory inTaiyuan city,North China,were studied.It was shown...The frequencies of chromosomal aberrationsof the peripheral blood lymphocytes from 40workers chronically exposed to sulphurdioxide (SO2) at a sulphuric acid factory inTaiyuan city,North China,were studied.It was shown that the mean frequencies ofchromosomal aberrations or lymphocytes展开更多
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants have caused>5oo million confirmed cases and>6 million deaths.Apart from the common clinical manifestations,63% of admitted coronavirus ...Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants have caused>5oo million confirmed cases and>6 million deaths.Apart from the common clinical manifestations,63% of admitted coronavirus disease 2019(COvID-19)patients had lymphopenia,increasingto 85% in patients with severe disease(Huang et al.,2020).展开更多
Since the outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 6 million cases are confirmed and over 300,000 cases are dead after infection.Dys...Since the outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 6 million cases are confirmed and over 300,000 cases are dead after infection.Dysfunction of immunity in COVID-19 patients has been considered as one of the fatal factors for patients,especially cytokine release syndrome and lymphopenia.1,2,3 The reduced number and increased exhaustion level of lymphocyte are associated with elevated inflammatory cytokines in COVID-19 patients.4,5 However,the mechanism of cytokine-induced lymphopenia in COVID-19 is very unclear.IL-2 is critical for the proliferation,differentiation,and function of T cells,including Tregs,CD4+,and CD8+effector cells.6 Here,we reported the negative relationship between the concentration of soluble IL-2 receptor(sIL-2R)and T-cell number in blood from COVID-19 patients.In vitro addition of recombinant CD25 could inhibit the proliferation and function of T cells from PBMC after stimulated with TCR signaling,which could be rescued by strong IL-2 signaling.Our data suggested the importance of IL-2 signaling in lymphopenia of COVID-19 patients.展开更多
Objective To investigate the clinicopathological features of primary gastrointestinal non-Hodgkin’s lymphomas (PGI-NHL) and their prognostic values.Methods The clinical and pathological data of 216 patients diagnosed...Objective To investigate the clinicopathological features of primary gastrointestinal non-Hodgkin’s lymphomas (PGI-NHL) and their prognostic values.Methods The clinical and pathological data of 216 patients diagnosed as PGI-NHL from Zhejiang Cancer Hospital展开更多
Objective To investigate the influence of microcystin-LR (MC-LR) on monocytes and lymphocytes in blood of mice and to find a sensitive index of toxic effects.Methods Specific pathogen free Kunming male mice,aging 1 mo...Objective To investigate the influence of microcystin-LR (MC-LR) on monocytes and lymphocytes in blood of mice and to find a sensitive index of toxic effects.Methods Specific pathogen free Kunming male mice,aging 1 month-old,were randomly divided into 5 groups展开更多
Objective To observe the effect of cisplatin alone or combined with anti-programmed death ligand 1 monoclonal antibody(anti-PD-L1 mA b)on the co-culture system of lung adenocarcinoma SPCA-1 cells and T lymphocytes,and...Objective To observe the effect of cisplatin alone or combined with anti-programmed death ligand 1 monoclonal antibody(anti-PD-L1 mA b)on the co-culture system of lung adenocarcinoma SPCA-1 cells and T lymphocytes,and therefore to study the immunotherapeutic effect of anti-PD-L1 mA b on lung cancer.Methods Human adenocarcinoma SPCA-1 cell line was selected展开更多
目的探讨重症支原体肺炎患儿合并肺部真菌感染的病原学特征及T淋巴细胞免疫特征。方法回顾性纳入2022年7月—2024年7月收治于太原市中心医院儿科的37例重症支原体肺炎合并真菌感染的患儿为A组;另纳入同期无任何并发症的50例重症支原体...目的探讨重症支原体肺炎患儿合并肺部真菌感染的病原学特征及T淋巴细胞免疫特征。方法回顾性纳入2022年7月—2024年7月收治于太原市中心医院儿科的37例重症支原体肺炎合并真菌感染的患儿为A组;另纳入同期无任何并发症的50例重症支原体肺炎患儿为B组,同时随机选取50例健康体检儿童为C组。分析A组的病原学特征;对比3组儿童的炎症指标[中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、淀粉样蛋白A(serumamyloid A,SAA)、红细胞沉降率(erythrocyte sedimentation Rate,ESR)]、肺功能指标[呼气峰流速(peak expiratory flow,PEF)、最大通气量(maximum voluntary ventilation VCMax,MVV)、第1秒用力呼气量占所有呼气量的比例(forced expiratory volume in one second to forced vital capacity ratio,FEV1/FVC)]、T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))及营养状况指标(维生素A、维生素D)。结果A组37例重症支原体肺炎合并肺部真菌感染的患儿共检出39株真菌,其中白念珠菌最多,其余依次为烟曲霉、毛霉、近平滑念珠菌和肺孢子菌。A、B两组患儿NLR、SAA、ESR、CD8^(+)水平均显著高于C组儿童,且A组显著高于B组,均存在显著差异(P<0.05);A、B两组患儿PEF、MVV、FEV1/FVC、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、维生素A、维生素D水平均显著低于C组儿童,且A组显著低于B组,差异均有统计学意义(P<0.05)。ROC结果显示:NLR、SAA、ESR、PEF、MVV、FEV1/FVC、CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、维生素A、维生素D预测重症支原体肺炎患儿合并肺部真菌感染均具有统计学意义(P<0.05)。结论重症支原体肺炎合并肺部真菌感染以白念珠菌感染为主,患儿体内存在较强的炎症反应与免疫功能紊乱,肺功能差且营养状况不佳。因此临床治疗需早期监测各项指标,尽早采取减轻炎症及调节免疫等综合治疗措施,重视真菌防治,改善患儿预后。展开更多
目的:对比肺癌患者与健康者之间淋巴细胞亚群差异,评估肺癌患者外周血T淋巴细胞亚群及自然杀伤细胞(NK)之基线值与预后的关系。方法:收集2006年2月至2013年3月就诊于天津医科大学肿瘤医院病例资料完整的肺癌患者105例,其中非小细胞肺癌(...目的:对比肺癌患者与健康者之间淋巴细胞亚群差异,评估肺癌患者外周血T淋巴细胞亚群及自然杀伤细胞(NK)之基线值与预后的关系。方法:收集2006年2月至2013年3月就诊于天津医科大学肿瘤医院病例资料完整的肺癌患者105例,其中非小细胞肺癌(NSCLC)86例、小细胞肺癌(SCLC)19例,另选健康对照35例,对比接受治疗前肺癌患者和健康对照者外周血中的CD3+T细胞、CD4+T细胞、CD8+T细胞及NK细胞所占百分比,并回顾性分析86例NSCLC患者初治时外周血淋巴细胞亚群与预后的关系。结果:肺癌患者外周血CD3+T细胞、CD4+T细胞、NK细胞及CD4/CD8比值均明显低于健康对照组(P=0.011,P=0.007,P<0.001,P=0.025),而CD8+T细胞比例高于健康对照组(P=0.013)。当CD8+T≥31.8%及CD4/CD8<1.28时NSCLC患者可以获得一个更长的OS(中位OS分别为36.2 m vs.20.0 m,P=0.010;30.8 m vs.20.0 m,P=0.035)。而CD3+T细胞、CD4+T细胞及NK细胞百分比对NSCLC患者预后无显著影响。结论:外周血CD8+T细胞基线水平较高的NSCLC患者生存较长,此基线水平可能对NSCLC患者预后有指示作用。展开更多
文摘Primary lymphoepithelioma-like carcinoma in the liver is extremely rare. A few cases of lymphoepithelioma-like cholangiocarcinoma have been reported, but few radiologic features were described. We reviewed 23 cases of lymphoepithelioma-like cholangiocarcinoma reported between 1996 and 2014 and describe a rare case of a 35-year-old woman in our hospital who was diagnosed with lymphoepithelioma-like cholangiocarcinoma of the liver and was a hepatitis B carrier. The tumor(1.6 cm) in our patient appeared to be hypoechoic in sonographic images and hypodense in computed tomography(CT) images. In addition, it was homogeneous hypointense in T1-weighted magnetic resonance(MR) images(MRI) and hyperintense in T2-weighted MRI. Dynamic gadolinium-enhanced MRI showed typical image pattern of hepatocellular carcinoma(HCC). The patient underwent a laparoscopic left hepatic lobectomy, and the resected tumor consisted of well-differentiated glandular cells with extensive lymphocytic infiltration that were immunoreactive to CK(AE1/AE3), CD3, and CD20. In addition, the tumor was positive for Epstein-Barr virus-encoded RNA in situ hybridization. Finally, lymphoepithelioma-like cholangiocarcinoma was diagnosed. In previous studies, the incidence is highest among middle-aged people. Most tumors appeared to be hypodense with either hypovascular or hypervascular patterns in CT images. This case report is the first study to address sonography, CT, and MRI observations and delineate pathologic correlations. We suggest that the imaging pattern of lymphoepithelioma-like cholangiocarcinoma, either the typical cholangiocarcinoma pattern or a mimic of HCC, should be considered in the differential lists for HCC.
文摘To the Editor:Post-transplant lymphoproliferative disorder（PTLD）is a rare and potentially fatal complication occurring after all types of solid organ transplantation.;PTLD accounts for 20%of all de novo post-transplant tumors.;The most important risk factors for PTLD are prolonged intense immunosuppression and Epstein-Barr virus（EBV）
文摘The purpose of this study is to check the effect ofDiabetes mellitus on DNA repair of peripheral lympho-cytes.With liquid scintillation counting,the valueof lymphocytes unscheduled ~3H-TdR incorporation in-dex in the aged patients with diabetes mellitus grou-
文摘The frequencies of chromosomal aberrationsof the peripheral blood lymphocytes from 40workers chronically exposed to sulphurdioxide (SO2) at a sulphuric acid factory inTaiyuan city,North China,were studied.It was shown that the mean frequencies ofchromosomal aberrations or lymphocytes
文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants have caused>5oo million confirmed cases and>6 million deaths.Apart from the common clinical manifestations,63% of admitted coronavirus disease 2019(COvID-19)patients had lymphopenia,increasingto 85% in patients with severe disease(Huang et al.,2020).
文摘Since the outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 6 million cases are confirmed and over 300,000 cases are dead after infection.Dysfunction of immunity in COVID-19 patients has been considered as one of the fatal factors for patients,especially cytokine release syndrome and lymphopenia.1,2,3 The reduced number and increased exhaustion level of lymphocyte are associated with elevated inflammatory cytokines in COVID-19 patients.4,5 However,the mechanism of cytokine-induced lymphopenia in COVID-19 is very unclear.IL-2 is critical for the proliferation,differentiation,and function of T cells,including Tregs,CD4+,and CD8+effector cells.6 Here,we reported the negative relationship between the concentration of soluble IL-2 receptor(sIL-2R)and T-cell number in blood from COVID-19 patients.In vitro addition of recombinant CD25 could inhibit the proliferation and function of T cells from PBMC after stimulated with TCR signaling,which could be rescued by strong IL-2 signaling.Our data suggested the importance of IL-2 signaling in lymphopenia of COVID-19 patients.
文摘Objective To investigate the clinicopathological features of primary gastrointestinal non-Hodgkin’s lymphomas (PGI-NHL) and their prognostic values.Methods The clinical and pathological data of 216 patients diagnosed as PGI-NHL from Zhejiang Cancer Hospital
文摘Objective To investigate the influence of microcystin-LR (MC-LR) on monocytes and lymphocytes in blood of mice and to find a sensitive index of toxic effects.Methods Specific pathogen free Kunming male mice,aging 1 month-old,were randomly divided into 5 groups
文摘Objective To observe the effect of cisplatin alone or combined with anti-programmed death ligand 1 monoclonal antibody(anti-PD-L1 mA b)on the co-culture system of lung adenocarcinoma SPCA-1 cells and T lymphocytes,and therefore to study the immunotherapeutic effect of anti-PD-L1 mA b on lung cancer.Methods Human adenocarcinoma SPCA-1 cell line was selected
文摘目的探讨重症支原体肺炎患儿合并肺部真菌感染的病原学特征及T淋巴细胞免疫特征。方法回顾性纳入2022年7月—2024年7月收治于太原市中心医院儿科的37例重症支原体肺炎合并真菌感染的患儿为A组;另纳入同期无任何并发症的50例重症支原体肺炎患儿为B组,同时随机选取50例健康体检儿童为C组。分析A组的病原学特征;对比3组儿童的炎症指标[中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、淀粉样蛋白A(serumamyloid A,SAA)、红细胞沉降率(erythrocyte sedimentation Rate,ESR)]、肺功能指标[呼气峰流速(peak expiratory flow,PEF)、最大通气量(maximum voluntary ventilation VCMax,MVV)、第1秒用力呼气量占所有呼气量的比例(forced expiratory volume in one second to forced vital capacity ratio,FEV1/FVC)]、T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))及营养状况指标(维生素A、维生素D)。结果A组37例重症支原体肺炎合并肺部真菌感染的患儿共检出39株真菌,其中白念珠菌最多,其余依次为烟曲霉、毛霉、近平滑念珠菌和肺孢子菌。A、B两组患儿NLR、SAA、ESR、CD8^(+)水平均显著高于C组儿童,且A组显著高于B组,均存在显著差异(P<0.05);A、B两组患儿PEF、MVV、FEV1/FVC、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、维生素A、维生素D水平均显著低于C组儿童,且A组显著低于B组,差异均有统计学意义(P<0.05)。ROC结果显示:NLR、SAA、ESR、PEF、MVV、FEV1/FVC、CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、维生素A、维生素D预测重症支原体肺炎患儿合并肺部真菌感染均具有统计学意义(P<0.05)。结论重症支原体肺炎合并肺部真菌感染以白念珠菌感染为主,患儿体内存在较强的炎症反应与免疫功能紊乱,肺功能差且营养状况不佳。因此临床治疗需早期监测各项指标,尽早采取减轻炎症及调节免疫等综合治疗措施,重视真菌防治,改善患儿预后。
文摘目的:对比肺癌患者与健康者之间淋巴细胞亚群差异,评估肺癌患者外周血T淋巴细胞亚群及自然杀伤细胞(NK)之基线值与预后的关系。方法:收集2006年2月至2013年3月就诊于天津医科大学肿瘤医院病例资料完整的肺癌患者105例,其中非小细胞肺癌(NSCLC)86例、小细胞肺癌(SCLC)19例,另选健康对照35例,对比接受治疗前肺癌患者和健康对照者外周血中的CD3+T细胞、CD4+T细胞、CD8+T细胞及NK细胞所占百分比,并回顾性分析86例NSCLC患者初治时外周血淋巴细胞亚群与预后的关系。结果:肺癌患者外周血CD3+T细胞、CD4+T细胞、NK细胞及CD4/CD8比值均明显低于健康对照组(P=0.011,P=0.007,P<0.001,P=0.025),而CD8+T细胞比例高于健康对照组(P=0.013)。当CD8+T≥31.8%及CD4/CD8<1.28时NSCLC患者可以获得一个更长的OS(中位OS分别为36.2 m vs.20.0 m,P=0.010;30.8 m vs.20.0 m,P=0.035)。而CD3+T细胞、CD4+T细胞及NK细胞百分比对NSCLC患者预后无显著影响。结论:外周血CD8+T细胞基线水平较高的NSCLC患者生存较长,此基线水平可能对NSCLC患者预后有指示作用。
