Bacteria have the ability to inhibit the growth of competitors by using contact-dependent killing devices,such as the bacterial-killing type IV secretion system(T4SS).A recent publication in The ISME Journal by Wang e...Bacteria have the ability to inhibit the growth of competitors by using contact-dependent killing devices,such as the bacterial-killing type IV secretion system(T4SS).A recent publication in The ISME Journal by Wang et al.(ISME J,2023.https://doi.org/10.1038/s41396-023-01533-7)uncovered that T4SS could deliver a unique“non-toxic”effector protein,LtaE,into interspecies bacterial cells.The delivery of LtaE by the bacteria Lysobacter enzymogenes induces the antifungal antibiotic 2,4-DAPG production by binding to the transcriptional repressor PhlF in another bacterial species,Pseudomonas protegens.As a result,P.protegens regains the capacity to protect plants from nearby fungal infections.This finding uncovered a novel role of T4SS in mediating interactions of interkingdom cooperation to kill microbial competitors in soil microbiomes.展开更多
文摘Bacteria have the ability to inhibit the growth of competitors by using contact-dependent killing devices,such as the bacterial-killing type IV secretion system(T4SS).A recent publication in The ISME Journal by Wang et al.(ISME J,2023.https://doi.org/10.1038/s41396-023-01533-7)uncovered that T4SS could deliver a unique“non-toxic”effector protein,LtaE,into interspecies bacterial cells.The delivery of LtaE by the bacteria Lysobacter enzymogenes induces the antifungal antibiotic 2,4-DAPG production by binding to the transcriptional repressor PhlF in another bacterial species,Pseudomonas protegens.As a result,P.protegens regains the capacity to protect plants from nearby fungal infections.This finding uncovered a novel role of T4SS in mediating interactions of interkingdom cooperation to kill microbial competitors in soil microbiomes.
