L1范数约束是目前稀疏地震反演比较常用的正则化方法,但利用L1范数并不能得到最优的稀疏解。为了进一步的得到更稀疏的结果,引入了一种基于Lp稀疏约束和交替方向乘子算法的波阻抗反演方法。从正则化方法出发,采用了比L1范数更为稀疏的L...L1范数约束是目前稀疏地震反演比较常用的正则化方法,但利用L1范数并不能得到最优的稀疏解。为了进一步的得到更稀疏的结果,引入了一种基于Lp稀疏约束和交替方向乘子算法的波阻抗反演方法。从正则化方法出发,采用了比L1范数更为稀疏的Lp范数对目标函数稀疏约束,在此基础上,加入了初始模型约束,旨在得到具有较高精度以及稳定性的反演结果。为了对Lp拟范数这类非凸优化问题进行求解,选择使用交替方向乘子算法(Alternating Direction Method of Multipliers),将目标函数分解为多个可以求解的子目标函数。为了验证反演方法的稳定性和实用性,分别选择了理论模型和实际数据对反演方法进行了测试,得到了较高精度的缝洞型储层预测结果。展开更多
[Objective]The paper was to study the effects of estradiol(E_(2))and progesterone(P4)on the expression of interleukin-1β(IL-1β)mRNA in lipopolysaccharide(LPS)-induced acute salpingitis in ovariectomized mice,and pre...[Objective]The paper was to study the effects of estradiol(E_(2))and progesterone(P4)on the expression of interleukin-1β(IL-1β)mRNA in lipopolysaccharide(LPS)-induced acute salpingitis in ovariectomized mice,and preliminarily explore the anti-inflammatory mechanism associated with estrogen and progesterone.[Method]Healthy female KM mice were randomly assigned to several groups:the sham operation group(LPS+SHAM),the ovarian removal group(LPS+OVX),the ovarian removal+estradiol group(LPS+OVX+E_(2)),the ovarian removal+progesterone group(LPS+OVX+P4),the LPS group and the control group(control).HE staining was conducted to assess the pathological changes in the fallopian tubes of each group.Additionally,the expression levels of IL-1βmRNA in the fallopian tubes of the mice were quantified using RT-qPCR.[Result]The histopathological changes in the fallopian tubes were examined.Estrogen and progesterone demonstrated a significant capacity to mitigate salpingitis induced by LPS.In comparison to the control group,the expression of IL-1βmRNA in the LPS group,LPS+SHAM group,and LPS+OVX+E_(2)group was significantly down-regulated(P<0.05).Furthermore,the expression of IL-1βmRNA in the LPS+OVX+P4 group exhibited an extremely significant down-regulation(P<0.01).When compared to the LPS+OVX group,the expression of IL-1βmRNA in the LPS+OVX+E_(2)group was significantly down-regulated(P<0.05),while the expression in the LPS+OVX+P4 group was extremely significantly down-regulated(P<0.01).[Conclusion]Estrogen and progesterone have the capacity to inhibit the expression of IL-1βmRNA in the inflammatory tissue of the fallopian tubes in mice,consequently diminishing the inflammatory response induced by LPS.展开更多
This study investigates the role of Interleukin 17(IL-17)in exacerbating periapical lesions caused by Porphyromonas gingivalis(Pg)lipopolysaccharides(LPS)in the context of metabolic disease and its potential impact on...This study investigates the role of Interleukin 17(IL-17)in exacerbating periapical lesions caused by Porphyromonas gingivalis(Pg)lipopolysaccharides(LPS)in the context of metabolic disease and its potential impact on glucose tolerance.Researchers developed a unique mouse model where mice were monocolonized with Pg to induce periapical lesions.After 1 month,they were fed a highfat diet(HFD)for 2 months to simulate metabolic disease and oral microbiota dysbiosis.To explore the role of LPS from Pg,wildtype(WT)mice were challenged with purified LPS from Porphyromonas gingivalis,as well as with LPS-depleted and non-depleted Pg bacteria;IL-17 knockout(KO)mice were also included to assess the role of IL-17 signaling.The impact on bone lysis,periapical injury,glucose intolerance,and immune response was assessed.Results showed that in WT mice,the presence of LPS significantly worsened bone lysis,Th17 cell recruitment,and periapical injury.IL-17 KO mice exhibited reduced bone loss,glucose intolerance,and immune cell infiltration.Additionally,inflammatory markers in adipose tissue were lower in IL-17 KO mice,despite increased dysbiosis.The findings suggest that IL-17 plays a critical role in amplifying Pg-induced periapical lesions and systemic metabolic disturbances.Targeting IL-17 recruitment could offer a novel approach to improving glycemic control and reducing type 2 diabetes(T2D)risk in individuals with periapical disease.展开更多
文摘L1范数约束是目前稀疏地震反演比较常用的正则化方法,但利用L1范数并不能得到最优的稀疏解。为了进一步的得到更稀疏的结果,引入了一种基于Lp稀疏约束和交替方向乘子算法的波阻抗反演方法。从正则化方法出发,采用了比L1范数更为稀疏的Lp范数对目标函数稀疏约束,在此基础上,加入了初始模型约束,旨在得到具有较高精度以及稳定性的反演结果。为了对Lp拟范数这类非凸优化问题进行求解,选择使用交替方向乘子算法(Alternating Direction Method of Multipliers),将目标函数分解为多个可以求解的子目标函数。为了验证反演方法的稳定性和实用性,分别选择了理论模型和实际数据对反演方法进行了测试,得到了较高精度的缝洞型储层预测结果。
基金Supported by Health Science and Technology Programme Project of Inner Mongolia Autonomous Region Health and Health Commission(202201194)General Program of Inner Mongolia Medical University(YKD2023MS032)+2 种基金Innovation and Entrepreneurship Training Program for College Students of Inner Mongolia Medical University(202210132059)Natural Science Foundation of Inner Mongolia Autonomous Region(2022LHMS03001)Talent Introduction Project of Inner Mongolia Autonomous Region in 2020.
文摘[Objective]The paper was to study the effects of estradiol(E_(2))and progesterone(P4)on the expression of interleukin-1β(IL-1β)mRNA in lipopolysaccharide(LPS)-induced acute salpingitis in ovariectomized mice,and preliminarily explore the anti-inflammatory mechanism associated with estrogen and progesterone.[Method]Healthy female KM mice were randomly assigned to several groups:the sham operation group(LPS+SHAM),the ovarian removal group(LPS+OVX),the ovarian removal+estradiol group(LPS+OVX+E_(2)),the ovarian removal+progesterone group(LPS+OVX+P4),the LPS group and the control group(control).HE staining was conducted to assess the pathological changes in the fallopian tubes of each group.Additionally,the expression levels of IL-1βmRNA in the fallopian tubes of the mice were quantified using RT-qPCR.[Result]The histopathological changes in the fallopian tubes were examined.Estrogen and progesterone demonstrated a significant capacity to mitigate salpingitis induced by LPS.In comparison to the control group,the expression of IL-1βmRNA in the LPS group,LPS+SHAM group,and LPS+OVX+E_(2)group was significantly down-regulated(P<0.05).Furthermore,the expression of IL-1βmRNA in the LPS+OVX+P4 group exhibited an extremely significant down-regulation(P<0.01).When compared to the LPS+OVX group,the expression of IL-1βmRNA in the LPS+OVX+E_(2)group was significantly down-regulated(P<0.05),while the expression in the LPS+OVX+P4 group was extremely significantly down-regulated(P<0.01).[Conclusion]Estrogen and progesterone have the capacity to inhibit the expression of IL-1βmRNA in the inflammatory tissue of the fallopian tubes in mice,consequently diminishing the inflammatory response induced by LPS.
基金supported by the Paul Calas Award from the French Society of Endodontics(SFE)。
文摘This study investigates the role of Interleukin 17(IL-17)in exacerbating periapical lesions caused by Porphyromonas gingivalis(Pg)lipopolysaccharides(LPS)in the context of metabolic disease and its potential impact on glucose tolerance.Researchers developed a unique mouse model where mice were monocolonized with Pg to induce periapical lesions.After 1 month,they were fed a highfat diet(HFD)for 2 months to simulate metabolic disease and oral microbiota dysbiosis.To explore the role of LPS from Pg,wildtype(WT)mice were challenged with purified LPS from Porphyromonas gingivalis,as well as with LPS-depleted and non-depleted Pg bacteria;IL-17 knockout(KO)mice were also included to assess the role of IL-17 signaling.The impact on bone lysis,periapical injury,glucose intolerance,and immune response was assessed.Results showed that in WT mice,the presence of LPS significantly worsened bone lysis,Th17 cell recruitment,and periapical injury.IL-17 KO mice exhibited reduced bone loss,glucose intolerance,and immune cell infiltration.Additionally,inflammatory markers in adipose tissue were lower in IL-17 KO mice,despite increased dysbiosis.The findings suggest that IL-17 plays a critical role in amplifying Pg-induced periapical lesions and systemic metabolic disturbances.Targeting IL-17 recruitment could offer a novel approach to improving glycemic control and reducing type 2 diabetes(T2D)risk in individuals with periapical disease.
