L1范数约束是目前稀疏地震反演比较常用的正则化方法,但利用L1范数并不能得到最优的稀疏解。为了进一步的得到更稀疏的结果,引入了一种基于Lp稀疏约束和交替方向乘子算法的波阻抗反演方法。从正则化方法出发,采用了比L1范数更为稀疏的L...L1范数约束是目前稀疏地震反演比较常用的正则化方法,但利用L1范数并不能得到最优的稀疏解。为了进一步的得到更稀疏的结果,引入了一种基于Lp稀疏约束和交替方向乘子算法的波阻抗反演方法。从正则化方法出发,采用了比L1范数更为稀疏的Lp范数对目标函数稀疏约束,在此基础上,加入了初始模型约束,旨在得到具有较高精度以及稳定性的反演结果。为了对Lp拟范数这类非凸优化问题进行求解,选择使用交替方向乘子算法(Alternating Direction Method of Multipliers),将目标函数分解为多个可以求解的子目标函数。为了验证反演方法的稳定性和实用性,分别选择了理论模型和实际数据对反演方法进行了测试,得到了较高精度的缝洞型储层预测结果。展开更多
目的:由连梅汤(LMD)对脂多糖(LPS)诱导的脓毒症小鼠回肠屏障及肝肺损伤的保护作用的研究。方法:采用随机方式,将C57/6J雄性小鼠分为对照组(CON组)、LPS模型组(LPS组)和连梅汤治疗组(LMD组),每组各6只。适应性喂养7天后,分别经口给予生...目的:由连梅汤(LMD)对脂多糖(LPS)诱导的脓毒症小鼠回肠屏障及肝肺损伤的保护作用的研究。方法:采用随机方式,将C57/6J雄性小鼠分为对照组(CON组)、LPS模型组(LPS组)和连梅汤治疗组(LMD组),每组各6只。适应性喂养7天后,分别经口给予生理盐水与治疗剂量的连梅汤(LMD) 21天。第22天,PBS注入对照组腹腔,另两组LPS注入5 mg/kg腹腔,建立脓毒症模型小鼠。腹腔注射24小时后进行回肠和肝、肺组织的收集。用HE染色组织病理鉴定;通过RT-qPCR检测回肠屏障因子水平(ZO-1, Occludin)和肝肺组织炎性因子(IL-1α, IL-8, TNF-α)。结果LPS组与CON相比,体重下降明显(n = 6;P β、IL-8、TNF-α)水平(n = 6;P Objective: The protective effect of Lianmei Decoction on the intestine was studied to the intestinal barrier, liver, and lung damage caused by lipopolysaccharide (LPS) in septic mice. Methods: C57/6J male mice were randomly assigned to the control group (CON group), LPS model group (LPS group), and Lianmei Decoction treatment group (LMD group), with 6 mice in each group. After 7 days of adaptive feeding, normal saline and a therapeutic dose of LMD were given orally for 21 days. In the 22 days of the study, PBS was injected intraperitoneally into the CON group, and 5 mg/kg LPS was administered intraperitoneally to the remaining two groups to create a sepsis mouse model. Ileum, liver, and lung tissues were gathered 24 hours after intraperitoneal injection. Histopathological examination was done using HE staining;the amounts of ileal barrier factors (ZO-1, Occludin) and inflammatory factors (IL-1β, IL-8, TNF-α) in liver and lung tissues were detected by RT-qPCR. Results: Compared with the CON group, the body weight of the LPS group decreased dramatically (n = 6;P β, IL-8, TNF-a) in liver and lung tissues (n = 6;P < 0.05), reduce the pathological damage of liver and pulmonary tissue. Conclusion: Lianmei Decoction can effectively improve ileal barrier damage, liver and lung injury, and inflammatory imbalance in LPS-induced sepsis mice.展开更多
背景:脂蛋白a(Lp(a))是急性心肌梗死(AMI)患者发生不良心血管事件的独立危险因素,与AMI后心脏重构密切相关。目的:本研究旨在探讨Lp(a)与急性前壁ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入(PCI)术后心室重构的关系以及对心肌梗死...背景:脂蛋白a(Lp(a))是急性心肌梗死(AMI)患者发生不良心血管事件的独立危险因素,与AMI后心脏重构密切相关。目的:本研究旨在探讨Lp(a)与急性前壁ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入(PCI)术后心室重构的关系以及对心肌梗死后心室重构的预测价值。方法:纳入本院行冠状动脉介入治疗的前壁STEMI患者218例,在心肌梗死后1周和6个月通过心脏超声评估左心室功能和体积。不良心室重构(VR)的定义是基于心肌梗死后6个月左室舒张末期容积增加≥20%。根据患者左心室重构情况分为心室重构组和非心室重构组。比较两组患者的Lp(a)及临床资料,采用多因素Logistic回归法分析影响前壁STEMI患者PCI术后左心室重构的相关因素;将独立危险因素创建受试者工作特征曲线(ROC),分析Lp(a)对心肌梗死后心室重构的预测价值。结果:6个月后,218例前壁STEMI患者中,58例患者出现心室重构。根据患者左心室重构情况分为心室重构组(160例)和非心室重构组(58例)。与非心室重构组比较,心室重构组年龄、糖尿病史、糖化血红蛋白、肌钙蛋白I、肌酸激酶同工酶、C反应蛋白、NT-proBNP、低密度脂蛋白胆固醇、Lp(a)、Gensini评分、室壁运动记分指数(WMSI)均显著升高,左心室射血分数(LVEF)显著下降,差异具有统计学意义;心室重构组LVEF显著降低,差异具有统计学意义;二元Logistic回归分析显示肌钙蛋白I、C反应蛋白、Lp(a)、LVEF是前壁STEMI患者PCI手术心室重构的独立危险因素。高Lp(a)是VR的独立预测因子(OR = 1.006, P Background: Lipoprotein a (Lp(a)) is an independent risk factor for adverse cardiovascular events in patients with acute myocardial infarction (AMI) and is closely related to cardiac remodeling after AMI. Objective: The purpose of this study was to investigate the relationship between Lp(a) and ventricular remodeling after percutaneous coronary intervention (PCI) in patients with acute anterior ST-elevation myocardial infarction (STEMI) and its predictive value after myocardial infarction. Methods: A total of 218 patients with anterior STEMI undergoing coronary intervention in our hospital were enrolled in our hospital, and left ventricular function and volume were evaluated by cardiac ultrasound at 1 week and 6 months after myocardial infarction. Poor ventricular remodeling (VR) is defined as a ≥ 20% increase in left ventricular end-diastolic volume 6 months after myocardial infarction. According to the left ventricular remodeling, the patients were divided into ventricular remodeling group and non-ventricular remodeling group. The Lp(a) and clinical data of the two groups were compared, and the multivariate logistic regression method was used to analyze the relevant factors affecting left ventricular remodeling after PCI in patients with anterior STEMI. The receiver operating characteristic curve (ROC) was created for independent risk factors, and the predictive value of Lp(a) in ventricular remodeling after myocardial infarction was analyzed. Results: After 6 months, ventricular remodeling occurred in 58 of the 218 patients with anterior STEMI. According to the left ventricular remodeling, the patients were divided into ventricular remodeling group (160 cases) and non-ventricular remodeling group (58 cases). Compared with the non-ventricular remodeling group, the age, diabetes history, glycosylated hemoglobin, troponin I, creatine kinase isoenzyme, C-reactive protein, NT-proBNP, low-density lipoprotein cholesterol, Lp(a), Gensini score, and wall motion scoring index (WMSI) in the ventricular remodeling group were significantly increased, and the left ventricular ejection fraction (LVEF) was significantly decreased, and the difference was statistically significant. LVEF was significantly reduced in the ventricular remodeling group, and the difference was statistically significant. Binary logistic regression analysis showed that troponin I, C-reactive protein, Lp(a) and LVEF were independent risk factors for ventricular remodeling after PCI in patients with anterior STEMI. High Lp(a) was an independent predictor of VR (OR = 1.006, P < 0.001). The optimal cut-off value of Lp(a) for predicting VR was 342, with a sensitivity of 82.6% and a specificity of 81.6% (AUC = 0.842, P < 0.001). Conclusion: Lp(a) is associated with left ventricular remodeling after percutaneous coronary intervention (PCI) in patients with anterior STEMI, and Lp(a) is a useful tool for predicting the risk of ventricular remodeling after myocardial infarction, and early clinical intervention is recommended.展开更多
文摘L1范数约束是目前稀疏地震反演比较常用的正则化方法,但利用L1范数并不能得到最优的稀疏解。为了进一步的得到更稀疏的结果,引入了一种基于Lp稀疏约束和交替方向乘子算法的波阻抗反演方法。从正则化方法出发,采用了比L1范数更为稀疏的Lp范数对目标函数稀疏约束,在此基础上,加入了初始模型约束,旨在得到具有较高精度以及稳定性的反演结果。为了对Lp拟范数这类非凸优化问题进行求解,选择使用交替方向乘子算法(Alternating Direction Method of Multipliers),将目标函数分解为多个可以求解的子目标函数。为了验证反演方法的稳定性和实用性,分别选择了理论模型和实际数据对反演方法进行了测试,得到了较高精度的缝洞型储层预测结果。
文摘目的:由连梅汤(LMD)对脂多糖(LPS)诱导的脓毒症小鼠回肠屏障及肝肺损伤的保护作用的研究。方法:采用随机方式,将C57/6J雄性小鼠分为对照组(CON组)、LPS模型组(LPS组)和连梅汤治疗组(LMD组),每组各6只。适应性喂养7天后,分别经口给予生理盐水与治疗剂量的连梅汤(LMD) 21天。第22天,PBS注入对照组腹腔,另两组LPS注入5 mg/kg腹腔,建立脓毒症模型小鼠。腹腔注射24小时后进行回肠和肝、肺组织的收集。用HE染色组织病理鉴定;通过RT-qPCR检测回肠屏障因子水平(ZO-1, Occludin)和肝肺组织炎性因子(IL-1α, IL-8, TNF-α)。结果LPS组与CON相比,体重下降明显(n = 6;P β、IL-8、TNF-α)水平(n = 6;P Objective: The protective effect of Lianmei Decoction on the intestine was studied to the intestinal barrier, liver, and lung damage caused by lipopolysaccharide (LPS) in septic mice. Methods: C57/6J male mice were randomly assigned to the control group (CON group), LPS model group (LPS group), and Lianmei Decoction treatment group (LMD group), with 6 mice in each group. After 7 days of adaptive feeding, normal saline and a therapeutic dose of LMD were given orally for 21 days. In the 22 days of the study, PBS was injected intraperitoneally into the CON group, and 5 mg/kg LPS was administered intraperitoneally to the remaining two groups to create a sepsis mouse model. Ileum, liver, and lung tissues were gathered 24 hours after intraperitoneal injection. Histopathological examination was done using HE staining;the amounts of ileal barrier factors (ZO-1, Occludin) and inflammatory factors (IL-1β, IL-8, TNF-α) in liver and lung tissues were detected by RT-qPCR. Results: Compared with the CON group, the body weight of the LPS group decreased dramatically (n = 6;P β, IL-8, TNF-a) in liver and lung tissues (n = 6;P < 0.05), reduce the pathological damage of liver and pulmonary tissue. Conclusion: Lianmei Decoction can effectively improve ileal barrier damage, liver and lung injury, and inflammatory imbalance in LPS-induced sepsis mice.
文摘背景:脂蛋白a(Lp(a))是急性心肌梗死(AMI)患者发生不良心血管事件的独立危险因素,与AMI后心脏重构密切相关。目的:本研究旨在探讨Lp(a)与急性前壁ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入(PCI)术后心室重构的关系以及对心肌梗死后心室重构的预测价值。方法:纳入本院行冠状动脉介入治疗的前壁STEMI患者218例,在心肌梗死后1周和6个月通过心脏超声评估左心室功能和体积。不良心室重构(VR)的定义是基于心肌梗死后6个月左室舒张末期容积增加≥20%。根据患者左心室重构情况分为心室重构组和非心室重构组。比较两组患者的Lp(a)及临床资料,采用多因素Logistic回归法分析影响前壁STEMI患者PCI术后左心室重构的相关因素;将独立危险因素创建受试者工作特征曲线(ROC),分析Lp(a)对心肌梗死后心室重构的预测价值。结果:6个月后,218例前壁STEMI患者中,58例患者出现心室重构。根据患者左心室重构情况分为心室重构组(160例)和非心室重构组(58例)。与非心室重构组比较,心室重构组年龄、糖尿病史、糖化血红蛋白、肌钙蛋白I、肌酸激酶同工酶、C反应蛋白、NT-proBNP、低密度脂蛋白胆固醇、Lp(a)、Gensini评分、室壁运动记分指数(WMSI)均显著升高,左心室射血分数(LVEF)显著下降,差异具有统计学意义;心室重构组LVEF显著降低,差异具有统计学意义;二元Logistic回归分析显示肌钙蛋白I、C反应蛋白、Lp(a)、LVEF是前壁STEMI患者PCI手术心室重构的独立危险因素。高Lp(a)是VR的独立预测因子(OR = 1.006, P Background: Lipoprotein a (Lp(a)) is an independent risk factor for adverse cardiovascular events in patients with acute myocardial infarction (AMI) and is closely related to cardiac remodeling after AMI. Objective: The purpose of this study was to investigate the relationship between Lp(a) and ventricular remodeling after percutaneous coronary intervention (PCI) in patients with acute anterior ST-elevation myocardial infarction (STEMI) and its predictive value after myocardial infarction. Methods: A total of 218 patients with anterior STEMI undergoing coronary intervention in our hospital were enrolled in our hospital, and left ventricular function and volume were evaluated by cardiac ultrasound at 1 week and 6 months after myocardial infarction. Poor ventricular remodeling (VR) is defined as a ≥ 20% increase in left ventricular end-diastolic volume 6 months after myocardial infarction. According to the left ventricular remodeling, the patients were divided into ventricular remodeling group and non-ventricular remodeling group. The Lp(a) and clinical data of the two groups were compared, and the multivariate logistic regression method was used to analyze the relevant factors affecting left ventricular remodeling after PCI in patients with anterior STEMI. The receiver operating characteristic curve (ROC) was created for independent risk factors, and the predictive value of Lp(a) in ventricular remodeling after myocardial infarction was analyzed. Results: After 6 months, ventricular remodeling occurred in 58 of the 218 patients with anterior STEMI. According to the left ventricular remodeling, the patients were divided into ventricular remodeling group (160 cases) and non-ventricular remodeling group (58 cases). Compared with the non-ventricular remodeling group, the age, diabetes history, glycosylated hemoglobin, troponin I, creatine kinase isoenzyme, C-reactive protein, NT-proBNP, low-density lipoprotein cholesterol, Lp(a), Gensini score, and wall motion scoring index (WMSI) in the ventricular remodeling group were significantly increased, and the left ventricular ejection fraction (LVEF) was significantly decreased, and the difference was statistically significant. LVEF was significantly reduced in the ventricular remodeling group, and the difference was statistically significant. Binary logistic regression analysis showed that troponin I, C-reactive protein, Lp(a) and LVEF were independent risk factors for ventricular remodeling after PCI in patients with anterior STEMI. High Lp(a) was an independent predictor of VR (OR = 1.006, P < 0.001). The optimal cut-off value of Lp(a) for predicting VR was 342, with a sensitivity of 82.6% and a specificity of 81.6% (AUC = 0.842, P < 0.001). Conclusion: Lp(a) is associated with left ventricular remodeling after percutaneous coronary intervention (PCI) in patients with anterior STEMI, and Lp(a) is a useful tool for predicting the risk of ventricular remodeling after myocardial infarction, and early clinical intervention is recommended.
