Low-level laser therapy(LLLT) may have an effect on the pain associated with orthodontic treatment. The aim of this study was to evaluate the effect of LLLT on pain and somatosensory sensitization induced by orthodont...Low-level laser therapy(LLLT) may have an effect on the pain associated with orthodontic treatment. The aim of this study was to evaluate the effect of LLLT on pain and somatosensory sensitization induced by orthodontic treatment. Forty individuals(12–33 years old; mean ± standard deviations: 20.8 ± 5.9 years) scheduled to receive orthodontic treatment were randomly divided into a laser group(LG) or a placebo group(PG)(1:1). The LG received LLLT(810-nm gallium-aluminium-arsenic diode laser in continuous mode with the power set at 400 mW, 2 J·cm–2) at 0 h, 2 h, 24 h, 4 d, and 7 d after treatment, and the PG received inactive treatment at the same time points. In both groups, the non-treated side served as a control. A numerical rating scale(NRS) of pain, pressure pain thresholds(PPTs), cold detection thresholds(CDTs), warmth detection thresholds(WDTs), cold pain thresholds(CPTs), and heat pain thresholds(HPTs) were tested on both sides at the gingiva and canine tooth and on the hand. The data were analysed by a repeated measures analysis of variance(ANOVA). The NRS pain scores were significantly lower in the LG group(P = 0.01). The CDTs,CPTs, WDTs, HPTs, and PPTs at the gingiva and the PPTs at the canine tooth were significantly less sensitive on the treatment side of the LG compared with that of the PG(P < 0.033). The parameters tested also showed significantly less sensitivity on the nontreatment side of the LG compared to that of the PG(P < 0.043). There were no differences between the groups for any quantitative sensory testing(QST) measures of the hand. The application of LLLT appears to reduce the pain and sensitivity of the tooth and gingiva associated with orthodontic treatment and may have contralateral effects within the trigeminal system but no generalized QST effects. Thus, the present study indicated a significant analgesia effect of LLLT application during orthodontic treatment.Further clinical applications are suggested.展开更多
Objective:To investigate the effect of Kangfuxin Solution(康复新液)combined with low-level laser therapy(LLLT)on cytokines and immune function in patients with radiation-induced oral mucositis.Methods:There were 84 na...Objective:To investigate the effect of Kangfuxin Solution(康复新液)combined with low-level laser therapy(LLLT)on cytokines and immune function in patients with radiation-induced oral mucositis.Methods:There were 84 nasopharyngeal carcinoma patients with oral mucositis after intensity-modulated radiation therapy(IMRT)were randomly divided into the control group(CG)and the observation group(OG),with 42 cases in each group.The CG was given LLLT,and the OG was treated with Kangfuxin Solution in addition to LLLT for 10 consecutive days.The healing time of oral mucosa,mucositis grading,oral pain scores,cytokines(interleukin-6,interleukin-1βand tumor necrosis factor-α)and T lymphocyte subsets were compared between the 2 groups before and after treatment.Results:The healing time of oral mucosa in the OG was(6.8±1.4)d,which was significantly shorter than(8.6±1.9)d in the CG(t=4.943,P<0.01).After treatment,the grading of oral mucositis in the OG was better than that in the CG,with a statistically significant difference(Z=2.942,P<0.05).The oral pain scores of the OG was lower than that in the CG at different time points after treatment,and the difference was statistically significant(t=8.207,11.017,P<0.01).After treatment,the levels of IL-6,IL-1βand TNF-αin peripheral blood of the OG were significantly lower than those in the CG(t=5.217,2.775,4.053,P<0.01).There were statistically significant differences in CD4+,CD8+and CD4+/CD8+between the OG and the CG after treatment(t=5.692,6.093,3.658,P<0.01).Conclusion:Kangfuxin Solution combined with LLLT can significantly shorten the healing time of oral mucosal,reduce the grading of oral mucositis,relieve oral pain,reduce inflammatory response and improve the immune function of patients.展开更多
Infants portray suggestive unique cries while sick, having belly pain, discomfort, tiredness, attention and desire for a change of diapers among other needs. There exists limited knowledge in accessing the infants’ n...Infants portray suggestive unique cries while sick, having belly pain, discomfort, tiredness, attention and desire for a change of diapers among other needs. There exists limited knowledge in accessing the infants’ needs as they only relay information through suggestive cries. Many teenagers tend to give birth at an early age, thereby exposing them to be the key monitors of their own babies. They tend not to have sufficient skills in monitoring the infant’s dire needs, more so during the early stages of infant development. Artificial intelligence has shown promising efficient predictive analytics from supervised, and unsupervised to reinforcement learning models. This study, therefore, seeks to develop an android app that could be used to discriminate the infant audio cries by leveraging the strength of convolution neural networks as a classifier model. Audio analytics from many kinds of literature is an untapped area by researchers as it’s attributed to messy and huge data generation. This study, therefore, strongly leverages convolution neural networks, a deep learning model that is capable of handling more than one-dimensional datasets. To achieve this, the audio data in form of a wave was converted to images through Mel spectrum frequencies which were classified using the computer vision CNN model. The Librosa library was used to convert the audio to Mel spectrum which was then presented as pixels serving as the input for classifying the audio classes such as sick, burping, tired, and hungry. The study goal was to incorporate the model as an android tool that can be utilized at the domestic level and hospital facilities for surveillance of the infant’s health and social needs status all time round.展开更多
目的探究视听语言智能康复技术联合治疗性游戏对语言发育迟缓(delayed language development,DLD)患儿言语功能的影响。方法纳入2022年2月~2023年1月我院收治的LDD患儿86例,随机分为观察组和对照组各43例。对照组行常规语言训练,观察组...目的探究视听语言智能康复技术联合治疗性游戏对语言发育迟缓(delayed language development,DLD)患儿言语功能的影响。方法纳入2022年2月~2023年1月我院收治的LDD患儿86例,随机分为观察组和对照组各43例。对照组行常规语言训练,观察组在对照组基础上使用视听语言智能康复技术联合治疗性游戏进行干预,均干预3个月。干预前后分别采用Gesell发育量表(gesell developmental schedules,GDS)、普通话听觉理解和表达能力标准化评估表(diagnostic receptive and expressive assessment of mandarin-comprehensive,DREAM-C)、口部运动量表评估两组患儿的发育商(developmental quotient,DQ)、语言发育水平、口部运动功能。结果干预后,观察组Gesell发育评分(语言行为、适应性行为、个人-社交行为)、DREAM-C评分(总体语言、听力理解、语言表达、语义、句法)、唇部、下颌和舌部功能均显著高于对照组(P<0.05)。结论视听语言智能康复技术联合治疗性游戏可促进DLD患儿智力发育,改善言语和口部运动功能。展开更多
三维(Three-dimension,3D)多媒体技术,尤其是和3D视频相比有所差距的3D音频技术受到了广泛的关注。当前三维音频技术研究可分为基于物理声场重建的多声道音频技术和基于感知的声音场景重建的多声道音频技术两大类。物理声场重建技术的...三维(Three-dimension,3D)多媒体技术,尤其是和3D视频相比有所差距的3D音频技术受到了广泛的关注。当前三维音频技术研究可分为基于物理声场重建的多声道音频技术和基于感知的声音场景重建的多声道音频技术两大类。物理声场重建技术的重要代表是基于球谐分解的声重放技术和波场合成技术(Wave field synthesis,WFS),基于感知的声音场景重建技术主要包括幅度平移技术(Amplitude panning,AP)和基于头相关传输函数的双耳重建技术(Head related transfer function,HRTF)。本文对上述4类三维音频技术及其对应的典型系统进行了介绍及对比分析,并对三维音频技术当前3大主要研究热点:空间听觉机制、三维音频压缩编码以及三维音频系统精简的现状与前沿技术进行了介绍。展开更多
基金funded by the Priority Academic Program Development of Jiangsu Higher Education Institution(Grant No.2014-37)the Jiangsu Provincial Health and Family Planning Commission(No.H201535)Orofacial Pain and TMD Research Unit,Institute of Stomatology,Affiliated Hospital of Stomatology,Nanjing Medical University,for their support
文摘Low-level laser therapy(LLLT) may have an effect on the pain associated with orthodontic treatment. The aim of this study was to evaluate the effect of LLLT on pain and somatosensory sensitization induced by orthodontic treatment. Forty individuals(12–33 years old; mean ± standard deviations: 20.8 ± 5.9 years) scheduled to receive orthodontic treatment were randomly divided into a laser group(LG) or a placebo group(PG)(1:1). The LG received LLLT(810-nm gallium-aluminium-arsenic diode laser in continuous mode with the power set at 400 mW, 2 J·cm–2) at 0 h, 2 h, 24 h, 4 d, and 7 d after treatment, and the PG received inactive treatment at the same time points. In both groups, the non-treated side served as a control. A numerical rating scale(NRS) of pain, pressure pain thresholds(PPTs), cold detection thresholds(CDTs), warmth detection thresholds(WDTs), cold pain thresholds(CPTs), and heat pain thresholds(HPTs) were tested on both sides at the gingiva and canine tooth and on the hand. The data were analysed by a repeated measures analysis of variance(ANOVA). The NRS pain scores were significantly lower in the LG group(P = 0.01). The CDTs,CPTs, WDTs, HPTs, and PPTs at the gingiva and the PPTs at the canine tooth were significantly less sensitive on the treatment side of the LG compared with that of the PG(P < 0.033). The parameters tested also showed significantly less sensitivity on the nontreatment side of the LG compared to that of the PG(P < 0.043). There were no differences between the groups for any quantitative sensory testing(QST) measures of the hand. The application of LLLT appears to reduce the pain and sensitivity of the tooth and gingiva associated with orthodontic treatment and may have contralateral effects within the trigeminal system but no generalized QST effects. Thus, the present study indicated a significant analgesia effect of LLLT application during orthodontic treatment.Further clinical applications are suggested.
文摘Objective:To investigate the effect of Kangfuxin Solution(康复新液)combined with low-level laser therapy(LLLT)on cytokines and immune function in patients with radiation-induced oral mucositis.Methods:There were 84 nasopharyngeal carcinoma patients with oral mucositis after intensity-modulated radiation therapy(IMRT)were randomly divided into the control group(CG)and the observation group(OG),with 42 cases in each group.The CG was given LLLT,and the OG was treated with Kangfuxin Solution in addition to LLLT for 10 consecutive days.The healing time of oral mucosa,mucositis grading,oral pain scores,cytokines(interleukin-6,interleukin-1βand tumor necrosis factor-α)and T lymphocyte subsets were compared between the 2 groups before and after treatment.Results:The healing time of oral mucosa in the OG was(6.8±1.4)d,which was significantly shorter than(8.6±1.9)d in the CG(t=4.943,P<0.01).After treatment,the grading of oral mucositis in the OG was better than that in the CG,with a statistically significant difference(Z=2.942,P<0.05).The oral pain scores of the OG was lower than that in the CG at different time points after treatment,and the difference was statistically significant(t=8.207,11.017,P<0.01).After treatment,the levels of IL-6,IL-1βand TNF-αin peripheral blood of the OG were significantly lower than those in the CG(t=5.217,2.775,4.053,P<0.01).There were statistically significant differences in CD4+,CD8+and CD4+/CD8+between the OG and the CG after treatment(t=5.692,6.093,3.658,P<0.01).Conclusion:Kangfuxin Solution combined with LLLT can significantly shorten the healing time of oral mucosal,reduce the grading of oral mucositis,relieve oral pain,reduce inflammatory response and improve the immune function of patients.
文摘Infants portray suggestive unique cries while sick, having belly pain, discomfort, tiredness, attention and desire for a change of diapers among other needs. There exists limited knowledge in accessing the infants’ needs as they only relay information through suggestive cries. Many teenagers tend to give birth at an early age, thereby exposing them to be the key monitors of their own babies. They tend not to have sufficient skills in monitoring the infant’s dire needs, more so during the early stages of infant development. Artificial intelligence has shown promising efficient predictive analytics from supervised, and unsupervised to reinforcement learning models. This study, therefore, seeks to develop an android app that could be used to discriminate the infant audio cries by leveraging the strength of convolution neural networks as a classifier model. Audio analytics from many kinds of literature is an untapped area by researchers as it’s attributed to messy and huge data generation. This study, therefore, strongly leverages convolution neural networks, a deep learning model that is capable of handling more than one-dimensional datasets. To achieve this, the audio data in form of a wave was converted to images through Mel spectrum frequencies which were classified using the computer vision CNN model. The Librosa library was used to convert the audio to Mel spectrum which was then presented as pixels serving as the input for classifying the audio classes such as sick, burping, tired, and hungry. The study goal was to incorporate the model as an android tool that can be utilized at the domestic level and hospital facilities for surveillance of the infant’s health and social needs status all time round.
文摘目的探究视听语言智能康复技术联合治疗性游戏对语言发育迟缓(delayed language development,DLD)患儿言语功能的影响。方法纳入2022年2月~2023年1月我院收治的LDD患儿86例,随机分为观察组和对照组各43例。对照组行常规语言训练,观察组在对照组基础上使用视听语言智能康复技术联合治疗性游戏进行干预,均干预3个月。干预前后分别采用Gesell发育量表(gesell developmental schedules,GDS)、普通话听觉理解和表达能力标准化评估表(diagnostic receptive and expressive assessment of mandarin-comprehensive,DREAM-C)、口部运动量表评估两组患儿的发育商(developmental quotient,DQ)、语言发育水平、口部运动功能。结果干预后,观察组Gesell发育评分(语言行为、适应性行为、个人-社交行为)、DREAM-C评分(总体语言、听力理解、语言表达、语义、句法)、唇部、下颌和舌部功能均显著高于对照组(P<0.05)。结论视听语言智能康复技术联合治疗性游戏可促进DLD患儿智力发育,改善言语和口部运动功能。
文摘三维(Three-dimension,3D)多媒体技术,尤其是和3D视频相比有所差距的3D音频技术受到了广泛的关注。当前三维音频技术研究可分为基于物理声场重建的多声道音频技术和基于感知的声音场景重建的多声道音频技术两大类。物理声场重建技术的重要代表是基于球谐分解的声重放技术和波场合成技术(Wave field synthesis,WFS),基于感知的声音场景重建技术主要包括幅度平移技术(Amplitude panning,AP)和基于头相关传输函数的双耳重建技术(Head related transfer function,HRTF)。本文对上述4类三维音频技术及其对应的典型系统进行了介绍及对比分析,并对三维音频技术当前3大主要研究热点:空间听觉机制、三维音频压缩编码以及三维音频系统精简的现状与前沿技术进行了介绍。
