Through a simple review of low-frequency variation of blocking pattern and diagnoses of observational data and combining some experience in forecast practice,we put forward some thought about the mechanism of formatio...Through a simple review of low-frequency variation of blocking pattern and diagnoses of observational data and combining some experience in forecast practice,we put forward some thought about the mechanism of formation and maintenance of the blocking flow pattern from the synoptic/climatological point of view,It is emphasized that eastward moving and deepening of troughs in the upstream of the blocking high,the SST anomalies and topography effect are the main factors of impelling the variation of the blocking high.During the maintenance of Ural blocking high wave-flow interactions are studied through disposition of baroclinic trough(transient wave)and the blocking flow.This study will offer a primary basis for the further theoretical study on the formation mechanism of the blocking high.展开更多
AIM:To study the relationships between amplitude of low-frequency fluctuations(ALFF)changes and clinical ophthalmic parameters in patients with primary open angle glaucoma(POAG)and analyze the diagnostic value of ALFF...AIM:To study the relationships between amplitude of low-frequency fluctuations(ALFF)changes and clinical ophthalmic parameters in patients with primary open angle glaucoma(POAG)and analyze the diagnostic value of ALFF.METHODS:Twenty-four POAG patients and 24 healthy controls(HCs)underwent resting-state functional magnetic resonance imaging(rs-fMRI).Nonparametric rank-sum tests were used to compare the ALFF values in the slow-4 and slow-5 bands,and Spearman or Pearson correlation analysis was used to assess the correlation between ALFF changes and clinical ophthalmic parameters in POAG patients.Receiver operating characteristic(ROC)curves were used to evaluate the diagnostic performance of the ALFF.RESULTS:There were 16 males in POAG patients(median age 48y)and 12 males in HCs(median age 39y).Compared with HCs,POAG patients presented increased or decreased ALFF values in different brain regions,and similar changes were observed in mild POAG patients.The ALFF values were correlated with retinal nerve fiber layer(RNFL)thickness,inner limiting membrane-retinal pigment epithelium thickness changes and the degree of visual field defects.Analysis of the diagnostic value of the ALFF via ROC curves revealed that the right medial frontal gyrus[area under the curve(AUC)=0.9063]and superior frontal gyrus(AUC=0.9097)had better diagnostic value than did the optic disc area(AUC=0.8019),visual field index(VFI%,AUC=0.8988)and macular parameters.CONCLUSION:POAG patients present altered cortical function that is significantly correlated with the optic nerve and retinal thickness and had good diagnostic value,which may reflect the underlying neuropathological mechanism of POAG.展开更多
Cirrus clouds play a crucial role in the energy balance of the Earth-atmosphere system.We investigated the spatiotemporal variations of cirrus over the South China Sea(SCS)using satellite data(MOD08,MYD08,CALIPSO)and ...Cirrus clouds play a crucial role in the energy balance of the Earth-atmosphere system.We investigated the spatiotemporal variations of cirrus over the South China Sea(SCS)using satellite data(MOD08,MYD08,CALIPSO)and reanalysis data(MERRA-2)from March 2007 to February 2015(eight years).The horizontal distribution reveals lower cirrus fraction values in the northern SCS and higher values in the southern region,with minima observed in March and April and maxima sequentially occurring in August(northern SCS,NSCS),September(middle SCS,MSCS),and December(southern SCS,SSCS).Vertically,the cirrus fraction peaks in summer and reaches its lowest levels in spring.Opaque cirrus dominates during summer in the NSCS and MSCS,comprising 53.6%and 55.9%,respectively,while the SSCS exhibits a higher frequency of opaque cirrus relative to other cloud types.Subvisible cirrus clouds have the lowest frequency year-round,whereas thin cirrus is most prominent in winter in the NSCS(46.3%)and in spring in the MSCS(45.3%).A case study from September 2021 further explores the influence of ice crystal habits on brightness temperature(BT)over the SCS.Simulations utilizing five ice crystal shapes from the ARTS DDA(Atmospheric Radiative Transfer Simulator Discrete Dipole Approximation)database and the RTTOV 12.4 radiative transfer model reveal that the 8-column-aggregate shape best represents BT in the NSCS and SSCS,while the large-block-aggregate shape performs better in the SSCS.展开更多
The National Geophysical Data Center(NGDC)of the United States has collected aeromagnetic data for input into a series of geomagnetic models to improve model resolution;however,in the Tibetan Plateau region,ground-bas...The National Geophysical Data Center(NGDC)of the United States has collected aeromagnetic data for input into a series of geomagnetic models to improve model resolution;however,in the Tibetan Plateau region,ground-based observations remain insufficient to clearly reflect the characteristics of the region’s lithospheric magnetism.In this study,we evaluate the lithospheric magnetism of the Tibetan Plateau by using a 3D surface spline model based on observations from>200 newly constructed repeat stations(portable stations)to determine the spatial distribution of plateau geomagnetism,as well as its correlation with the tectonic features of the region.We analyze the relationships between M≥5 earthquakes and lithospheric magnetic field variations on the Tibetan Plateau and identify regions susceptible to strong earthquakes.We compare the geomagnetic results with those from an enhanced magnetic model(EMM2015)developed by the NGDC and provide insights into improving lithospheric magnetic field calculations in the Tibetan Plateau region.Further research reveals that these magnetic anomalies exhibit distinct differences from the magnetic-seismic correlation mechanisms observed in other tectonic settings;here,they are governed primarily by the combined effects of compressional magnetism,thermal magnetism,and deep thermal stress.This study provides new evidence of geomagnetic anomalies on the Tibetan Plateau,interprets them physically,and demonstrates their potential for identifying seismic hazard zones on the Plateau.展开更多
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive degeneration of upper and lower motor neurons in the brainstem and spinal cord,leading to muscle weakness,para...Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive degeneration of upper and lower motor neurons in the brainstem and spinal cord,leading to muscle weakness,paralysis,and respiratory failure (Morgan and Orrell,2016).展开更多
The wave rays and their seasonal variation of stationary and low-frequency Rossby waves are studied by using the Runge-Kutta scheme. The results show that for stationary waves the rays can reach lower latitudes in win...The wave rays and their seasonal variation of stationary and low-frequency Rossby waves are studied by using the Runge-Kutta scheme. The results show that for stationary waves the rays can reach lower latitudes in winter, and are limited in higher latitudes in summer. The main differences between the stationary and low-frequency wave rays are that low-frequency waves can propagate across the equator and the easterlies will not be an obstacle on their propagation. It explained to some extent the interaction of disturbances between the Northern and Southern Hemispheres. The lower wave frequencies and the stronger easterly flow are, the more difficult low-frequency waves will be to propagate across the equator. The waves with 20-day period are easier to propagate across the equator than that with 50-day period. The winter is the most favorable season for low-frequency waves to propagate into another hemisphere.展开更多
Pulse excitation or vibration stimulation was imposed on the low permeable formation with cracks to enhance the production or injection capacity.During that process,a coupling of wave-induced flow and initial flow in ...Pulse excitation or vibration stimulation was imposed on the low permeable formation with cracks to enhance the production or injection capacity.During that process,a coupling of wave-induced flow and initial flow in dual-porous media was involved.Researchers had done much work on the rule of wave propagation in fractured porous media,whereas attentions on the variation law of flow in developing low permeable formation with cracks under vibration stimulation were not paid.In this study,the effect of low-frequency vibration on the seepage in dual-porous media was examined for the application of wave stimulation technology in developing reservoirs with natural cracks.A model for seepage of single-phase liquid in porous media with cracks under low-frequency vibration excitation was built by combining wave propagating theory for porous media with cracks and dual-porous media seepage mechanics.A governing equation group for the model,which was expressed by dimensionless fluid and solid displacements,was derived and solved with a numerical method.Variable physical properties were simulated to check the applicability of external low-frequency vibration load on dual-porous media and a parametric study for various vibration parameters.Stimulation of low-frequency vibration affected flow velocities of crack and rock matrix fluids.Compared with that in single-porous media,the stimulation effect on the fluid inner matrix of dual-porous media was relatively weakened.Different optimal vibration parameters were needed to increase the channeling flow between the crack and rock matrix or to only promote the flow velocity in the rock matrix.The theoretical study examines wave-coupled seepage field in fractured porous media with results that are applicable for low-frequency stimulation technology.展开更多
Halocarbons play a vital role in ozone depletion and global warming,and are regulated by the Montreal Protocol(MP)and its amendments.China has been identified as an important contributor to the halocarbon emissions,bu...Halocarbons play a vital role in ozone depletion and global warming,and are regulated by the Montreal Protocol(MP)and its amendments.China has been identified as an important contributor to the halocarbon emissions,but the regional sources of halocarbons in China are not yet well comprehended.To investigate the characteristics,emissions,and source profiles,this study conducted a field campaign in Xiamen,a coastal city in southeastern China.Higher enhancements were found in the unregulated halocarbons(CH_(3)Cl,CH_(2)Cl_(2),CHCl_(3))than in the MP eliminated species(CCl_(4),CH_(3)Br)and theMP controlled species(HCFCs,HFCs).Many of the measured halocarbons varied seasonally and regionally,depending on the anthropogenic sources and atmospheric transport.Backward trajectory analysis showed that the air masses from inland were polluted over Shandong,Hebei,and northern Fujian in the cold season,while the air masses fromthe sea in the warm season were clean.Different air masses in two seasons were associated with the halocarbon patterns in the study area.Industrial activities,especially solvent usage,were the primary sources of halocarbons.The emission hot spots in Fujian Province were concentrated in Sanming,Fuzhou,and Xiamen,and the unregulated halocarbons made the largest contribution.This study provides an insight for a deep understanding of the characteristics and potential sources of halocarbons,and for strengthened management of halocarbons in China.展开更多
Epigenetics-mediated breeding(epibreeding)involves engineering crop traits and stress responses through the targeted manipulation of key epigenetic features to enhance agricultural productivity.While conventional bree...Epigenetics-mediated breeding(epibreeding)involves engineering crop traits and stress responses through the targeted manipulation of key epigenetic features to enhance agricultural productivity.While conventional breeding methods raise concerns about reduced genetic diversity,epibreeding propels crop improvement through epigenetic variations that regulate gene expression,ultimately impacting crop yield.Epigenetic regulation in crops encompasses various modes,including histone modification,DNA modification,RNA modification,non-coding RNA,and chromatin remodeling.This review summarizes the epigenetic mechanisms underlying major agronomic traits in maize and identifies candidate epigenetic landmarks in the maize breeding process.We propose a valuable strategy for improving maize yield through epibreeding,combining CRISPR/Cas-based epigenome editing technology and Synthetic Epigenetics(SynEpi).Finally,we discuss the challenges and opportunities associated with maize trait improvement through epibreeding.展开更多
In this paper,an advanced satellite navigation filter design,referred to as the Variational Bayesian Maximum Correntropy Extended Kalman Filter(VBMCEKF),is introduced to enhance robustness and adaptability in scenario...In this paper,an advanced satellite navigation filter design,referred to as the Variational Bayesian Maximum Correntropy Extended Kalman Filter(VBMCEKF),is introduced to enhance robustness and adaptability in scenarios with non-Gaussian noise and heavy-tailed outliers.The proposed design modifies the extended Kalman filter(EKF)for the global navigation satellite system(GNSS),integrating the maximum correntropy criterion(MCC)and the variational Bayesian(VB)method.This adaptive algorithm effectively reduces non-line-of-sight(NLOS)reception contamination and improves estimation accuracy,particularly in time-varying GNSS measurements.Experimental results show that the proposed method significantly outperforms conventional approaches in estimation accuracy under heavy-tailed outliers and non-Gaussian noise.By combining MCC with VB approximation for real-time noise covariance estimation using fixed-point iteration,the VBMCEKF achieves superior filtering performance in challenging GNSS conditions.The method’s adaptability and precision make it ideal for improving satellite navigation performance in stochastic environments.展开更多
Southerly moisture surges over the central South China Sea(SCS)are characterized by the strengthening of lowlevel southerlies that transport moisture northward from the Pacific or Indian Oceans to South China.These su...Southerly moisture surges over the central South China Sea(SCS)are characterized by the strengthening of lowlevel southerlies that transport moisture northward from the Pacific or Indian Oceans to South China.These surge events typically occur for days in the early-summer season(from April to June)and can lead to heavy rains in South China.This study categorizes surge events into three types of flow patterns and examines their multiscale variations and impacts on rainfall.The first type occurs mainly in April,with the southeasterlies enhanced by a deepening trough in South China and the western Pacific subtropical high established over the SCS.The second type of surge events mostly appears in June,featuring the prevailing southwesterlies of summer monsoon from the Indian Ocean during the active phases of intraseasonal oscillations.Most surge events exhibit semi-diurnal variations with morning and afternoon peaks of northward moisture fluxes.Specifically,the first type features a dominant afternoon peak,while the second type shows a dominant early-morning peak,which is induced by thermal contrast between the Indochina Peninsula and the SCS.In general,the surge events enhance moisture convergence and increase rainfall downstream in South China,but they show some regional differences.The second type strengthens moisture convergence and rainfall in coastal regions with a morning peak.In contrast,the first type enhances inland rainfall with a morning peak,while moisture divergence dominates coastal regions.The third type of surge events denotes transitional conditions between the first two types,in terms of atmospheric circulations,diurnal cycles,and rainfall patterns.These results highlight a diversity of regional moisture surges and related rainfall ranging from diurnal to sub-seasonal scales.展开更多
Subtropical evergreen broad-leaved trees are usually vulnerable to freezing stress,while hexaploid wild Camellia oleifera shows strong freezing tolerance.As a valuable genetic resource of woody oil crop C.oleifera,wil...Subtropical evergreen broad-leaved trees are usually vulnerable to freezing stress,while hexaploid wild Camellia oleifera shows strong freezing tolerance.As a valuable genetic resource of woody oil crop C.oleifera,wild C.oleifera can serve as a case for studying the molecular bases of adaptive evolution to freezing stress.Here,47 wild C.oleifera from 11 natural distribution sites in China and 4 relative species of C.oleifera were selected for genome sequencing.“Min Temperature of Coldest Month”(BIO6)had the highest comprehensive contribution to wild C.oleifera distribution.The population genetic structure of wild C.oleifera could be divided into two groups:in cold winter(BIO6≤0℃)and warm winter(BIO6>0℃)areas.Wild C.oleifera in cold winter areas might have experienced stronger selection pressures and population bottlenecks with lower N_(e) than those in warm winter areas.155 singlenucleotide polymorphisms(SNPs)were significantly correlated with the key bioclimatic variables(106 SNPs significantly correlated with BIO6).Twenty key SNPs and 15 key copy number variation regions(CNVRs)were found with genotype differentiation>50%between the two groups of wild C.oleifera.Key SNPs in cis-regulatory elements might affect the expression of key genes associated with freezing tolerance,and they were also found within a CNVR suggesting interactions between them.Some key CNVRs in the exon regions were closely related to the differentially expressed genes under freezing stress.The findings suggest that rich SNPs and CNVRs in polyploid trees may contribute to the adaptive evolution to freezing stress.展开更多
BACKGROUND Various stone factors can affect the net results of shock wave lithotripsy(SWL).Recently a new factor called variation coefficient of stone density(VCSD)is being considered to have an impact on stone free r...BACKGROUND Various stone factors can affect the net results of shock wave lithotripsy(SWL).Recently a new factor called variation coefficient of stone density(VCSD)is being considered to have an impact on stone free rates.AIM To assess the role of VCSD in determining success of SWL in urinary calculi.METHODS Charts review was utilized for collection of data variables.The patients were subjected to SWL,using an electromagnetic lithotripter.Mean stone density(MSD),stone heterogeneity index(SHI),and VCSD were calculated by generating regions of interest on computed tomography(CT)images.Role of these factors were determined by applying the relevant statistical tests for continuous and categorical variables and a P value of<0.05 was gauged to be statistically significant.RESULTS There were a total of 407 patients included in the analysis.The mean age of the subjects in this study was 38.89±14.61 years.In total,165 out of the 407 patients could not achieve stone free status.The successful group had a significantly lower stone volume as compared to the unsuccessful group(P<0.0001).Skin to stone distance was not dissimilar among the two groups(P=0.47).MSD was significantly lower in the successful group(P<0.0001).SHI and VCSD were both significantly higher in the successful group(P<0.0001).CONCLUSION VCSD,a useful CT based parameter,can be utilized to gauge stone fragility and hence the prediction of SWL outcomes.展开更多
In this paper,we use the solution of the even functional Minkowski problem to show that there is a minimizing affine Minkowski total variation of the function of bounded variation.Moreover,for the Minkowski total vari...In this paper,we use the solution of the even functional Minkowski problem to show that there is a minimizing affine Minkowski total variation of the function of bounded variation.Moreover,for the Minkowski total variation,we use the method of convexation to establish the same conclusion as the convex body space.展开更多
The purpose of this article is to introduce a new method with a self-adaptive stepsize for approximating a common solution of monotone inclusion problems and variational inequality problems in reflexive Banach spaces....The purpose of this article is to introduce a new method with a self-adaptive stepsize for approximating a common solution of monotone inclusion problems and variational inequality problems in reflexive Banach spaces.The strong convergence result for our method is established under some standard assumptions without any requirement of the knowledge of the Lipschitz constant of the mapping.Several numerical experiments are provided to verify the advantages and efficiency of proposed algorithms.展开更多
Nonlinear variations in the coordinate time series of global navigation satellite system(GNSS) reference stations are strongly correlated with surface displacements caused by environmental loading effects,including at...Nonlinear variations in the coordinate time series of global navigation satellite system(GNSS) reference stations are strongly correlated with surface displacements caused by environmental loading effects,including atmospheric, hydrological, and nontidal ocean loading. Continuous improvements in the accuracy of surface mass loading products, performance of Earth models, and precise data-processing technologies have significantly advanced research on the effects of environmental loading on nonlinear variations in GNSS coordinate time series. However, owing to theoretical limitations, the lack of high spatiotemporal resolution surface mass observations, and the coupling of GNSS technology-related systematic errors, environmental loading and nonlinear GNSS reference station displacements remain inconsistent. The applicability and capability of these loading products across different regions also require further evaluation. This paper outlines methods for modeling environmental loading, surface mass loading products, and service organizations. In addition, it summarizes recent advances in applying environmental loading to address nonlinear variations in global and regional GNSS coordinate time series. Moreover, the scientific questions of existing studies are summarized, and insights into future research directions are provided. The complex nonlinear motion of reference stations is a major factor limiting the accuracy of the current terrestrial reference frame. Further refining the environmental load modeling method, establishing a surface mass distribution model with high spatiotemporal resolution and reliability, exploring other environmental load factors such as ice sheet and artificial mass-change effects, and developing an optimal data-processing model and strategy for reprocessing global reference station data consistently could contribute to the development of a millimeter-level nonlinear motion model for GNSS reference stations with actual physical significance and provide theoretical support for establishing a terrestrial reference frame with 1 mm accuracy by 2050.展开更多
In order to obtain a lower frequency band gap,this paper proposes a novel locally resonant meta-beam incorporating a softening nonlinear factor.An improved camroller structure is designed in this meta-beam to achieve ...In order to obtain a lower frequency band gap,this paper proposes a novel locally resonant meta-beam incorporating a softening nonlinear factor.An improved camroller structure is designed in this meta-beam to achieve the softening nonlinear stiffness of the local oscillators.Firstly,based on Hamilton's principle and the Galerkin method,the control equations for the coupled system are established.The theoretical band gap boundary is then derived with the modal analysis method.The theoretical results reveal that the band gap of the meta-beam shifts towards lower frequencies due to the presence of a softening nonlinear factor,distinguishing it from both linear metamaterials and those with hardening nonlinear characteristics.Then,the vibration attenuation characteristics of a finite size meta-beam are investigated through numerical calculation,and are verified by the theoretical results.Furthermore,parameter studies indicate that the reasonable design of the local oscillator parameters based on lightweight principles helps to achieve further broadband and efficient vibration reduction in the low-frequency region.Finally,a prototype of the meta-beam is fabricated and assembled,and the formations of the low-frequency band gap and the amplitude-induced band gap phenomenon are verified through experiments.展开更多
Low-frequency vibroseis acquisition has become a routine operation in land seismic surveys,given the advantages of low-frequency signals in characterizing geological structures and enhancing the imaging of deep explor...Low-frequency vibroseis acquisition has become a routine operation in land seismic surveys,given the advantages of low-frequency signals in characterizing geological structures and enhancing the imaging of deep exploration targets.The two key points of low-frequency sweep design techniques include controlling the distortion and improving the output energy during the low-frequency stage.However,the vibrators are limited by the maximum fl ow provided by the hydraulic systems at the low-frequency stage,causing difficulty in satisfying exploration energy requirements.Initially,a theoretical analysis of the low-frequency acquisition performance of vibrators is conducted.A theoretical maximum output force below 10 Hz is obtained by guiding through theoretical formulas and combining actual vibrator parameters.Then,the signal is optimized according to the surface characteristics of the operation area.Finally,detailed application quality control and operational procedures are established.The new low-frequency sweep design method has overcome the maximum flow limitations of the hydraulic system,increased the low-frequency energy,and achieved broadband acquisition.The designed signal has been tested and applied on various types of ground surfaces in the Middle East desert region,yielding good performance.The proposed low-frequency sweep design method holds considerable value for the application of conventional vibroseis in low-frequency acquisition.展开更多
Controlling low-frequency noise presents a significant challenge for traditional sound absorption materials,such as foams and fibrous substances.Recently developed acoustic absorption metamaterials,which rely on local...Controlling low-frequency noise presents a significant challenge for traditional sound absorption materials,such as foams and fibrous substances.Recently developed acoustic absorption metamaterials,which rely on local resonance can effectively balance the volume occupation and low-frequency absorption performance.However,these materials often exhibit a very narrow and fixed absorption band.Inspired by Helmholtz resonators and bistable structures,we propose bistable reconfigurable acoustic metamaterials(BRAMs)that offer multiband low-frequency absorption.These BRAMs are fabricated using shape-memory polylactic acid(SM-PLA)via four-dimension(4D)printing technology.Consequently,the geometry and absorption performance of the BRAMs can be adjusted by applying thermal stimuli(at 55℃)to switch between two stable states.The BRAMs demonstrate excellent low-frequency absorption with multiband characteristics,achieving an absorption coefficient of 0.981 at 136 Hz and 0.998 at 230 Hz for stable state I,and coefficients of 0.984 at 156 Hz and 0.961 at 542 Hz for stable state II.It was found that the BRAMs with different inclined plate angles had linear recovery stages,and the recovery speeds range from 0.75 mm/s to 1.1 mm/s.By combining a rational structural design and 4D printing,the reported reconfigurable acoustic metamaterials will inspire further studies on the design of dynamic and broadband absorption devices.展开更多
Metamaterials can control and manipulate acoustic/elastic waves on a subwavelength scale using cavities or additional components.However,the large cavity and weak stiffness components of traditional metamaterials may ...Metamaterials can control and manipulate acoustic/elastic waves on a subwavelength scale using cavities or additional components.However,the large cavity and weak stiffness components of traditional metamaterials may cause a conflict between vibroacoustic reduction and load-bearing capacity,and thus limit their application.Here,we propose a lightweight multifunctional metamaterial that can simultaneously achieve low-frequency sound insulation,broadband vibration reduction,and excellent load-bearing performance,named as vibroacoustic isolation and bearing metamaterial(VIBM).The advent of additive manufacturing technology provides a convenient and reliable method for the fabrication of VIBM samples.The results show that the compressive strength of the VIBM is as high as 9.71 MPa,which is nearly 87.81%higher than that of the conventional grid structure(CGS)under the same volume fraction.Moreover,the vibration and sound transmission are significantly reduced over a low and wide frequency range,which agrees well with the experimental data,and the reduction degree is obviously larger than that obtained by the CGS.The design strategy can effectively realize the key components of metamaterials and improve their application scenarios.展开更多
基金National Natural Science Foundation of China under Grant No.49675257.
文摘Through a simple review of low-frequency variation of blocking pattern and diagnoses of observational data and combining some experience in forecast practice,we put forward some thought about the mechanism of formation and maintenance of the blocking flow pattern from the synoptic/climatological point of view,It is emphasized that eastward moving and deepening of troughs in the upstream of the blocking high,the SST anomalies and topography effect are the main factors of impelling the variation of the blocking high.During the maintenance of Ural blocking high wave-flow interactions are studied through disposition of baroclinic trough(transient wave)and the blocking flow.This study will offer a primary basis for the further theoretical study on the formation mechanism of the blocking high.
基金Supported by National Natural Science Foundation of China(No.82260203).
文摘AIM:To study the relationships between amplitude of low-frequency fluctuations(ALFF)changes and clinical ophthalmic parameters in patients with primary open angle glaucoma(POAG)and analyze the diagnostic value of ALFF.METHODS:Twenty-four POAG patients and 24 healthy controls(HCs)underwent resting-state functional magnetic resonance imaging(rs-fMRI).Nonparametric rank-sum tests were used to compare the ALFF values in the slow-4 and slow-5 bands,and Spearman or Pearson correlation analysis was used to assess the correlation between ALFF changes and clinical ophthalmic parameters in POAG patients.Receiver operating characteristic(ROC)curves were used to evaluate the diagnostic performance of the ALFF.RESULTS:There were 16 males in POAG patients(median age 48y)and 12 males in HCs(median age 39y).Compared with HCs,POAG patients presented increased or decreased ALFF values in different brain regions,and similar changes were observed in mild POAG patients.The ALFF values were correlated with retinal nerve fiber layer(RNFL)thickness,inner limiting membrane-retinal pigment epithelium thickness changes and the degree of visual field defects.Analysis of the diagnostic value of the ALFF via ROC curves revealed that the right medial frontal gyrus[area under the curve(AUC)=0.9063]and superior frontal gyrus(AUC=0.9097)had better diagnostic value than did the optic disc area(AUC=0.8019),visual field index(VFI%,AUC=0.8988)and macular parameters.CONCLUSION:POAG patients present altered cortical function that is significantly correlated with the optic nerve and retinal thickness and had good diagnostic value,which may reflect the underlying neuropathological mechanism of POAG.
基金supported by the National Natural Science Foundation of China(Grant Nos.42027804,41775026,and 41075012)。
文摘Cirrus clouds play a crucial role in the energy balance of the Earth-atmosphere system.We investigated the spatiotemporal variations of cirrus over the South China Sea(SCS)using satellite data(MOD08,MYD08,CALIPSO)and reanalysis data(MERRA-2)from March 2007 to February 2015(eight years).The horizontal distribution reveals lower cirrus fraction values in the northern SCS and higher values in the southern region,with minima observed in March and April and maxima sequentially occurring in August(northern SCS,NSCS),September(middle SCS,MSCS),and December(southern SCS,SSCS).Vertically,the cirrus fraction peaks in summer and reaches its lowest levels in spring.Opaque cirrus dominates during summer in the NSCS and MSCS,comprising 53.6%and 55.9%,respectively,while the SSCS exhibits a higher frequency of opaque cirrus relative to other cloud types.Subvisible cirrus clouds have the lowest frequency year-round,whereas thin cirrus is most prominent in winter in the NSCS(46.3%)and in spring in the MSCS(45.3%).A case study from September 2021 further explores the influence of ice crystal habits on brightness temperature(BT)over the SCS.Simulations utilizing five ice crystal shapes from the ARTS DDA(Atmospheric Radiative Transfer Simulator Discrete Dipole Approximation)database and the RTTOV 12.4 radiative transfer model reveal that the 8-column-aggregate shape best represents BT in the NSCS and SSCS,while the large-block-aggregate shape performs better in the SSCS.
基金supported by the CAS Pioneer Hundred Talents Program and Second Tibetan Plateau Scientific Expedition Research Program(2019QZKK0708)as well as the Basic Research Program of Qinghai Province:Lithospheric Geomagnetic Field of the Qinghai‒Tibet Plateau and the Relationship with Strong Earthquakes(2021-ZJ-969Q).
文摘The National Geophysical Data Center(NGDC)of the United States has collected aeromagnetic data for input into a series of geomagnetic models to improve model resolution;however,in the Tibetan Plateau region,ground-based observations remain insufficient to clearly reflect the characteristics of the region’s lithospheric magnetism.In this study,we evaluate the lithospheric magnetism of the Tibetan Plateau by using a 3D surface spline model based on observations from>200 newly constructed repeat stations(portable stations)to determine the spatial distribution of plateau geomagnetism,as well as its correlation with the tectonic features of the region.We analyze the relationships between M≥5 earthquakes and lithospheric magnetic field variations on the Tibetan Plateau and identify regions susceptible to strong earthquakes.We compare the geomagnetic results with those from an enhanced magnetic model(EMM2015)developed by the NGDC and provide insights into improving lithospheric magnetic field calculations in the Tibetan Plateau region.Further research reveals that these magnetic anomalies exhibit distinct differences from the magnetic-seismic correlation mechanisms observed in other tectonic settings;here,they are governed primarily by the combined effects of compressional magnetism,thermal magnetism,and deep thermal stress.This study provides new evidence of geomagnetic anomalies on the Tibetan Plateau,interprets them physically,and demonstrates their potential for identifying seismic hazard zones on the Plateau.
文摘Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive degeneration of upper and lower motor neurons in the brainstem and spinal cord,leading to muscle weakness,paralysis,and respiratory failure (Morgan and Orrell,2016).
文摘The wave rays and their seasonal variation of stationary and low-frequency Rossby waves are studied by using the Runge-Kutta scheme. The results show that for stationary waves the rays can reach lower latitudes in winter, and are limited in higher latitudes in summer. The main differences between the stationary and low-frequency wave rays are that low-frequency waves can propagate across the equator and the easterlies will not be an obstacle on their propagation. It explained to some extent the interaction of disturbances between the Northern and Southern Hemispheres. The lower wave frequencies and the stronger easterly flow are, the more difficult low-frequency waves will be to propagate across the equator. The waves with 20-day period are easier to propagate across the equator than that with 50-day period. The winter is the most favorable season for low-frequency waves to propagate into another hemisphere.
基金the Scientific and Technological Research Project of Higher Education Institutions in Hebei Province(QN2019163)China Postdoctoral Science Foundation(2018M631765)+1 种基金the Doctoral Funds of Yanshan University(BL17024)a grant from Hebei Province Postdoctoral Advanced Programs(B2018003011).
文摘Pulse excitation or vibration stimulation was imposed on the low permeable formation with cracks to enhance the production or injection capacity.During that process,a coupling of wave-induced flow and initial flow in dual-porous media was involved.Researchers had done much work on the rule of wave propagation in fractured porous media,whereas attentions on the variation law of flow in developing low permeable formation with cracks under vibration stimulation were not paid.In this study,the effect of low-frequency vibration on the seepage in dual-porous media was examined for the application of wave stimulation technology in developing reservoirs with natural cracks.A model for seepage of single-phase liquid in porous media with cracks under low-frequency vibration excitation was built by combining wave propagating theory for porous media with cracks and dual-porous media seepage mechanics.A governing equation group for the model,which was expressed by dimensionless fluid and solid displacements,was derived and solved with a numerical method.Variable physical properties were simulated to check the applicability of external low-frequency vibration load on dual-porous media and a parametric study for various vibration parameters.Stimulation of low-frequency vibration affected flow velocities of crack and rock matrix fluids.Compared with that in single-porous media,the stimulation effect on the fluid inner matrix of dual-porous media was relatively weakened.Different optimal vibration parameters were needed to increase the channeling flow between the crack and rock matrix or to only promote the flow velocity in the rock matrix.The theoretical study examines wave-coupled seepage field in fractured porous media with results that are applicable for low-frequency stimulation technology.
基金supported by the National Natural Science Foundation of China(Nos.42030707,72394404)the International Partnership Program of the Chinese Academy of Sciences(No.121311KYSB20190029)the Fundamental Research Fund for the Central Universities(Nos.20720210083,20720210082).
文摘Halocarbons play a vital role in ozone depletion and global warming,and are regulated by the Montreal Protocol(MP)and its amendments.China has been identified as an important contributor to the halocarbon emissions,but the regional sources of halocarbons in China are not yet well comprehended.To investigate the characteristics,emissions,and source profiles,this study conducted a field campaign in Xiamen,a coastal city in southeastern China.Higher enhancements were found in the unregulated halocarbons(CH_(3)Cl,CH_(2)Cl_(2),CHCl_(3))than in the MP eliminated species(CCl_(4),CH_(3)Br)and theMP controlled species(HCFCs,HFCs).Many of the measured halocarbons varied seasonally and regionally,depending on the anthropogenic sources and atmospheric transport.Backward trajectory analysis showed that the air masses from inland were polluted over Shandong,Hebei,and northern Fujian in the cold season,while the air masses fromthe sea in the warm season were clean.Different air masses in two seasons were associated with the halocarbon patterns in the study area.Industrial activities,especially solvent usage,were the primary sources of halocarbons.The emission hot spots in Fujian Province were concentrated in Sanming,Fuzhou,and Xiamen,and the unregulated halocarbons made the largest contribution.This study provides an insight for a deep understanding of the characteristics and potential sources of halocarbons,and for strengthened management of halocarbons in China.
基金supported by funding from the National Key R&D Program of China(2023ZD0407304)the Sci-Tech Innovation 2030 Agenda(2022ZD0115703)Fundamental Research Funds for Central Non-Profit of Chinese Academy of Agricultural Sciences(Y2023PT20).
文摘Epigenetics-mediated breeding(epibreeding)involves engineering crop traits and stress responses through the targeted manipulation of key epigenetic features to enhance agricultural productivity.While conventional breeding methods raise concerns about reduced genetic diversity,epibreeding propels crop improvement through epigenetic variations that regulate gene expression,ultimately impacting crop yield.Epigenetic regulation in crops encompasses various modes,including histone modification,DNA modification,RNA modification,non-coding RNA,and chromatin remodeling.This review summarizes the epigenetic mechanisms underlying major agronomic traits in maize and identifies candidate epigenetic landmarks in the maize breeding process.We propose a valuable strategy for improving maize yield through epibreeding,combining CRISPR/Cas-based epigenome editing technology and Synthetic Epigenetics(SynEpi).Finally,we discuss the challenges and opportunities associated with maize trait improvement through epibreeding.
基金supported by the National Science and Technology Council,Taiwan under grants NSTC 111-2221-E-019-047 and NSTC 112-2221-E-019-030.
文摘In this paper,an advanced satellite navigation filter design,referred to as the Variational Bayesian Maximum Correntropy Extended Kalman Filter(VBMCEKF),is introduced to enhance robustness and adaptability in scenarios with non-Gaussian noise and heavy-tailed outliers.The proposed design modifies the extended Kalman filter(EKF)for the global navigation satellite system(GNSS),integrating the maximum correntropy criterion(MCC)and the variational Bayesian(VB)method.This adaptive algorithm effectively reduces non-line-of-sight(NLOS)reception contamination and improves estimation accuracy,particularly in time-varying GNSS measurements.Experimental results show that the proposed method significantly outperforms conventional approaches in estimation accuracy under heavy-tailed outliers and non-Gaussian noise.By combining MCC with VB approximation for real-time noise covariance estimation using fixed-point iteration,the VBMCEKF achieves superior filtering performance in challenging GNSS conditions.The method’s adaptability and precision make it ideal for improving satellite navigation performance in stochastic environments.
基金Guangdong Major Project of Basic and Applied Basic Research(2020B0301030004)National Natural Science Foundation of China(42475003)Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(SML2023SP209)。
文摘Southerly moisture surges over the central South China Sea(SCS)are characterized by the strengthening of lowlevel southerlies that transport moisture northward from the Pacific or Indian Oceans to South China.These surge events typically occur for days in the early-summer season(from April to June)and can lead to heavy rains in South China.This study categorizes surge events into three types of flow patterns and examines their multiscale variations and impacts on rainfall.The first type occurs mainly in April,with the southeasterlies enhanced by a deepening trough in South China and the western Pacific subtropical high established over the SCS.The second type of surge events mostly appears in June,featuring the prevailing southwesterlies of summer monsoon from the Indian Ocean during the active phases of intraseasonal oscillations.Most surge events exhibit semi-diurnal variations with morning and afternoon peaks of northward moisture fluxes.Specifically,the first type features a dominant afternoon peak,while the second type shows a dominant early-morning peak,which is induced by thermal contrast between the Indochina Peninsula and the SCS.In general,the surge events enhance moisture convergence and increase rainfall downstream in South China,but they show some regional differences.The second type strengthens moisture convergence and rainfall in coastal regions with a morning peak.In contrast,the first type enhances inland rainfall with a morning peak,while moisture divergence dominates coastal regions.The third type of surge events denotes transitional conditions between the first two types,in terms of atmospheric circulations,diurnal cycles,and rainfall patterns.These results highlight a diversity of regional moisture surges and related rainfall ranging from diurnal to sub-seasonal scales.
基金funded by the National Natural Science Foundation of China(grant no.32270238 and 31870311).
文摘Subtropical evergreen broad-leaved trees are usually vulnerable to freezing stress,while hexaploid wild Camellia oleifera shows strong freezing tolerance.As a valuable genetic resource of woody oil crop C.oleifera,wild C.oleifera can serve as a case for studying the molecular bases of adaptive evolution to freezing stress.Here,47 wild C.oleifera from 11 natural distribution sites in China and 4 relative species of C.oleifera were selected for genome sequencing.“Min Temperature of Coldest Month”(BIO6)had the highest comprehensive contribution to wild C.oleifera distribution.The population genetic structure of wild C.oleifera could be divided into two groups:in cold winter(BIO6≤0℃)and warm winter(BIO6>0℃)areas.Wild C.oleifera in cold winter areas might have experienced stronger selection pressures and population bottlenecks with lower N_(e) than those in warm winter areas.155 singlenucleotide polymorphisms(SNPs)were significantly correlated with the key bioclimatic variables(106 SNPs significantly correlated with BIO6).Twenty key SNPs and 15 key copy number variation regions(CNVRs)were found with genotype differentiation>50%between the two groups of wild C.oleifera.Key SNPs in cis-regulatory elements might affect the expression of key genes associated with freezing tolerance,and they were also found within a CNVR suggesting interactions between them.Some key CNVRs in the exon regions were closely related to the differentially expressed genes under freezing stress.The findings suggest that rich SNPs and CNVRs in polyploid trees may contribute to the adaptive evolution to freezing stress.
文摘BACKGROUND Various stone factors can affect the net results of shock wave lithotripsy(SWL).Recently a new factor called variation coefficient of stone density(VCSD)is being considered to have an impact on stone free rates.AIM To assess the role of VCSD in determining success of SWL in urinary calculi.METHODS Charts review was utilized for collection of data variables.The patients were subjected to SWL,using an electromagnetic lithotripter.Mean stone density(MSD),stone heterogeneity index(SHI),and VCSD were calculated by generating regions of interest on computed tomography(CT)images.Role of these factors were determined by applying the relevant statistical tests for continuous and categorical variables and a P value of<0.05 was gauged to be statistically significant.RESULTS There were a total of 407 patients included in the analysis.The mean age of the subjects in this study was 38.89±14.61 years.In total,165 out of the 407 patients could not achieve stone free status.The successful group had a significantly lower stone volume as compared to the unsuccessful group(P<0.0001).Skin to stone distance was not dissimilar among the two groups(P=0.47).MSD was significantly lower in the successful group(P<0.0001).SHI and VCSD were both significantly higher in the successful group(P<0.0001).CONCLUSION VCSD,a useful CT based parameter,can be utilized to gauge stone fragility and hence the prediction of SWL outcomes.
基金Supported in part by NSFC(No.11971005)the Fundamental Research Funds for the Central Universities(Nos.GK202101008,GK202102012)。
文摘In this paper,we use the solution of the even functional Minkowski problem to show that there is a minimizing affine Minkowski total variation of the function of bounded variation.Moreover,for the Minkowski total variation,we use the method of convexation to establish the same conclusion as the convex body space.
基金Supported by NSFC(No.12171062)the Natural Science Foundation of Chongqing(No.CSTB2022NSCQ-JQX0004)+1 种基金the Chongqing Talent Support Program(No.cstc2024ycjh-bgzxm0121)Science and Technology Project of Chongqing Education Committee(No.KJZD-M202300503)。
文摘The purpose of this article is to introduce a new method with a self-adaptive stepsize for approximating a common solution of monotone inclusion problems and variational inequality problems in reflexive Banach spaces.The strong convergence result for our method is established under some standard assumptions without any requirement of the knowledge of the Lipschitz constant of the mapping.Several numerical experiments are provided to verify the advantages and efficiency of proposed algorithms.
基金supported by the Basic Science Center Project of the National Natural Science Foundation of China(42388102)the National Natural Science Foundation of China(42174030)+2 种基金the Special Fund of Hubei Luojia Laboratory(220100020)the Major Science and Technology Program for Hubei Province(2022AAA002)the Fundamental Research Funds for the Central Universities of China(2042022dx0001 and 2042023kfyq01)。
文摘Nonlinear variations in the coordinate time series of global navigation satellite system(GNSS) reference stations are strongly correlated with surface displacements caused by environmental loading effects,including atmospheric, hydrological, and nontidal ocean loading. Continuous improvements in the accuracy of surface mass loading products, performance of Earth models, and precise data-processing technologies have significantly advanced research on the effects of environmental loading on nonlinear variations in GNSS coordinate time series. However, owing to theoretical limitations, the lack of high spatiotemporal resolution surface mass observations, and the coupling of GNSS technology-related systematic errors, environmental loading and nonlinear GNSS reference station displacements remain inconsistent. The applicability and capability of these loading products across different regions also require further evaluation. This paper outlines methods for modeling environmental loading, surface mass loading products, and service organizations. In addition, it summarizes recent advances in applying environmental loading to address nonlinear variations in global and regional GNSS coordinate time series. Moreover, the scientific questions of existing studies are summarized, and insights into future research directions are provided. The complex nonlinear motion of reference stations is a major factor limiting the accuracy of the current terrestrial reference frame. Further refining the environmental load modeling method, establishing a surface mass distribution model with high spatiotemporal resolution and reliability, exploring other environmental load factors such as ice sheet and artificial mass-change effects, and developing an optimal data-processing model and strategy for reprocessing global reference station data consistently could contribute to the development of a millimeter-level nonlinear motion model for GNSS reference stations with actual physical significance and provide theoretical support for establishing a terrestrial reference frame with 1 mm accuracy by 2050.
基金supported by the National Natural Science Foundation of China(Nos.12172014,U224126412332001)。
文摘In order to obtain a lower frequency band gap,this paper proposes a novel locally resonant meta-beam incorporating a softening nonlinear factor.An improved camroller structure is designed in this meta-beam to achieve the softening nonlinear stiffness of the local oscillators.Firstly,based on Hamilton's principle and the Galerkin method,the control equations for the coupled system are established.The theoretical band gap boundary is then derived with the modal analysis method.The theoretical results reveal that the band gap of the meta-beam shifts towards lower frequencies due to the presence of a softening nonlinear factor,distinguishing it from both linear metamaterials and those with hardening nonlinear characteristics.Then,the vibration attenuation characteristics of a finite size meta-beam are investigated through numerical calculation,and are verified by the theoretical results.Furthermore,parameter studies indicate that the reasonable design of the local oscillator parameters based on lightweight principles helps to achieve further broadband and efficient vibration reduction in the low-frequency region.Finally,a prototype of the meta-beam is fabricated and assembled,and the formations of the low-frequency band gap and the amplitude-induced band gap phenomenon are verified through experiments.
基金The authors would like to express their sincere appreciation to the research project of CNPC Geophysical Key Lab(2022DQ0604-4)National Natural Science Foundation of China(Grant No.42074141).
文摘Low-frequency vibroseis acquisition has become a routine operation in land seismic surveys,given the advantages of low-frequency signals in characterizing geological structures and enhancing the imaging of deep exploration targets.The two key points of low-frequency sweep design techniques include controlling the distortion and improving the output energy during the low-frequency stage.However,the vibrators are limited by the maximum fl ow provided by the hydraulic systems at the low-frequency stage,causing difficulty in satisfying exploration energy requirements.Initially,a theoretical analysis of the low-frequency acquisition performance of vibrators is conducted.A theoretical maximum output force below 10 Hz is obtained by guiding through theoretical formulas and combining actual vibrator parameters.Then,the signal is optimized according to the surface characteristics of the operation area.Finally,detailed application quality control and operational procedures are established.The new low-frequency sweep design method has overcome the maximum flow limitations of the hydraulic system,increased the low-frequency energy,and achieved broadband acquisition.The designed signal has been tested and applied on various types of ground surfaces in the Middle East desert region,yielding good performance.The proposed low-frequency sweep design method holds considerable value for the application of conventional vibroseis in low-frequency acquisition.
基金financially supported by National Key Research and Development Program of China(Grant No.2023YFB4604800)National Natural Science Foundation of China(Grant No.52275331)financial support from the Hong Kong Scholars Program(Grant No.XJ2022014).
文摘Controlling low-frequency noise presents a significant challenge for traditional sound absorption materials,such as foams and fibrous substances.Recently developed acoustic absorption metamaterials,which rely on local resonance can effectively balance the volume occupation and low-frequency absorption performance.However,these materials often exhibit a very narrow and fixed absorption band.Inspired by Helmholtz resonators and bistable structures,we propose bistable reconfigurable acoustic metamaterials(BRAMs)that offer multiband low-frequency absorption.These BRAMs are fabricated using shape-memory polylactic acid(SM-PLA)via four-dimension(4D)printing technology.Consequently,the geometry and absorption performance of the BRAMs can be adjusted by applying thermal stimuli(at 55℃)to switch between two stable states.The BRAMs demonstrate excellent low-frequency absorption with multiband characteristics,achieving an absorption coefficient of 0.981 at 136 Hz and 0.998 at 230 Hz for stable state I,and coefficients of 0.984 at 156 Hz and 0.961 at 542 Hz for stable state II.It was found that the BRAMs with different inclined plate angles had linear recovery stages,and the recovery speeds range from 0.75 mm/s to 1.1 mm/s.By combining a rational structural design and 4D printing,the reported reconfigurable acoustic metamaterials will inspire further studies on the design of dynamic and broadband absorption devices.
基金Project supported by the National Natural Science Foundation of China(Nos.11991032 and 52241103)the Hunan Province Graduate Research Innovation Project of China(No.KY0409052440)。
文摘Metamaterials can control and manipulate acoustic/elastic waves on a subwavelength scale using cavities or additional components.However,the large cavity and weak stiffness components of traditional metamaterials may cause a conflict between vibroacoustic reduction and load-bearing capacity,and thus limit their application.Here,we propose a lightweight multifunctional metamaterial that can simultaneously achieve low-frequency sound insulation,broadband vibration reduction,and excellent load-bearing performance,named as vibroacoustic isolation and bearing metamaterial(VIBM).The advent of additive manufacturing technology provides a convenient and reliable method for the fabrication of VIBM samples.The results show that the compressive strength of the VIBM is as high as 9.71 MPa,which is nearly 87.81%higher than that of the conventional grid structure(CGS)under the same volume fraction.Moreover,the vibration and sound transmission are significantly reduced over a low and wide frequency range,which agrees well with the experimental data,and the reduction degree is obviously larger than that obtained by the CGS.The design strategy can effectively realize the key components of metamaterials and improve their application scenarios.
