In recent years,deep learning has been introduced into the field of Single-pixel imaging(SPI),garnering significant attention.However,conventional networks still exhibit limitations in preserving image details.To addr...In recent years,deep learning has been introduced into the field of Single-pixel imaging(SPI),garnering significant attention.However,conventional networks still exhibit limitations in preserving image details.To address this issue,we integrate Large Kernel Convolution(LKconv)into the U-Net framework,proposing an enhanced network structure named U-LKconv network,which significantly enhances the capability to recover image details even under low sampling conditions.展开更多
目的:探讨玫瑰痤疮患者采用低能量Pixel调Q像束激光与米诺环素联合治疗后红斑情况及面部功能改善情况。方法:研究对象选自于2020年3月-2023年7月在上海交通大学医学院苏州九龙医院接受治疗的玫瑰痤疮患者110例,并分为对照组和观察组,每...目的:探讨玫瑰痤疮患者采用低能量Pixel调Q像束激光与米诺环素联合治疗后红斑情况及面部功能改善情况。方法:研究对象选自于2020年3月-2023年7月在上海交通大学医学院苏州九龙医院接受治疗的玫瑰痤疮患者110例,并分为对照组和观察组,每组例数均为55例,分组方法为随机数字表法。对照组给予盐酸米诺环素片,在对照组患者治疗的基础上,采用低能量Pixel调Q像束激光对观察组患者进行治疗。两组治疗时间均为6周。比较两组临床疗效(治疗6周后),玫瑰痤疮情况、整体病情、p38丝裂原活化蛋白激酶(p38 mitogen activated protein kinase,p38MAPK)通路蛋白、生活质量、红斑情况、面部功能、炎性因子(治疗前、治疗6周后),不良反应(治疗期间)。结果:治疗6周后,观察组总有效率高于对照组(76.36%vs.54.55%,P<0.05)。与治疗前比较,两组治疗6周后的玫瑰痤疮医师全球评分(Patient's global assessment,PGA)、整体病情评估(Investigator global assessment,IGA)、皮肤病生活质量量表(Dermatology life quality index,DLQI)评分、红斑评估量表(Clinician′s erythema assessment,CEA)评分、皮损区红斑指数(Erythema index,EI)、经皮水分丢失(Trans epidermal water loss,TEWL)、皮肤酸碱度(Pondus Hydrogenii,pH)值、炎性因子及p38MAPK通路蛋白相关因子水平均降低,且相比于对照组,观察组更低;两组角质层含水量均升高,且相比于对照组,观察组更高(P<0.05)。观察组和对照组治疗期间的不良反应发生率比较差异无统计学意义(P>0.05)。结论:玫瑰痤疮患者经低能量Pixel调Q像束激光联合米诺环素治疗后,其相关临床症状可得到有效缓解,炎症反应得以减轻,并可调节p38MAPK信号通路蛋白的表达,进一步可促进患者红斑情况及面部功能的改善,进而促使患者生活质量及临床疗效得以提高,且具有良好的安全性。展开更多
Visual cortical prostheses have the potential to restore partial vision. Still limited by the low-resolution visual percepts provided by visual cortical prostheses, implant wearers can currently only ＂see＂ pixelized...Visual cortical prostheses have the potential to restore partial vision. Still limited by the low-resolution visual percepts provided by visual cortical prostheses, implant wearers can currently only ＂see＂ pixelized images, and how to obtain the specific brain responses to different pixelized images in the primary visual cortex（the implant area） is still unknown. We conducted a functional magnetic resonance imaging experiment on normal human participants to investigate the brain activation patterns in response to 18 different pixelized images. There were 100 voxels in the brain activation pattern that were selected from the primary visual cortex, and voxel size was 4 mm × 4 mm × 4 mm. Multi-voxel pattern analysis was used to test if these 18 different brain activation patterns were specific. We chose a Linear Support Vector Machine（LSVM） as the classifier in this study. The results showed that the classification accuracies of different brain activation patterns were significantly above chance level, which suggests that the classifier can successfully distinguish the brain activation patterns. Our results suggest that the specific brain activation patterns to different pixelized images can be obtained in the primary visual cortex using a 4 mm × 4 mm × 4 mm voxel size and a 100-voxel pattern.展开更多
目的:观察低能量Pixel调Q像束激光联合盐酸米诺环素治疗玫瑰痤疮安全性和疗效。方法:选取某三甲医院门诊收治的玫瑰痤疮患者100例,按照随机数字法分为药物治疗组(32例)、激光治疗组(34例)与联合组(34例),药物治疗组采用单独盐酸米诺环...目的:观察低能量Pixel调Q像束激光联合盐酸米诺环素治疗玫瑰痤疮安全性和疗效。方法:选取某三甲医院门诊收治的玫瑰痤疮患者100例,按照随机数字法分为药物治疗组(32例)、激光治疗组(34例)与联合组(34例),药物治疗组采用单独盐酸米诺环素治疗,每晚1次,100 mg口服,连续治疗6周;激光治疗组采用低能量Pixel调Q像束激光治疗,2周1次,连续6周;联合组采用低能量Pixel调Q像束激光联合盐酸米诺环素100 mg口服每晚1次,连续6周治疗。治疗结束后比较3组患者整体病情的评估(investigator’s global assessment,IGA)。结果:治疗前3组患者IGA评分差异无统计学意义,治疗结束后,联合组患者整体病情评估IGA评分、症状积分均较2个对照组改善明显(P<0.01)。结论:低能量Pixel调Q像束激光联合米诺环素治疗玫瑰痤疮效果良好,不良反应少。展开更多
电子轰击型有源像素传感器(Electron Bombarded Active Pixel Sensor,EBAPS)作为一种数字化微光成像器件,以其成像系统具有小型化、低成本和低功耗的优势,以及在昼夜条件下连续拍摄时具备清晰成像的能力,成为微光成像领域的研究热点。...电子轰击型有源像素传感器(Electron Bombarded Active Pixel Sensor,EBAPS)作为一种数字化微光成像器件,以其成像系统具有小型化、低成本和低功耗的优势,以及在昼夜条件下连续拍摄时具备清晰成像的能力,成为微光成像领域的研究热点。文章基于国产某型EBAPS微光器件,利用FPGA作为核心处理器,完成了EBAPS器件驱动电路、图像处理和跟踪电路、显示电路的设计。同时,构建了满足昼夜复用的光学系统,搭建了一种小型化的手持成像跟踪系统。实验结果表明,该EBAPS昼夜成像系统可在1×10^(-4)~1×10^(4) lx照度条件下实现良好的成像和跟踪效果。展开更多
红外焦平面的数字读出是信息化发展的必然方向,其关键技术是数字读出电路。介绍了数字读出电路的发展现状和主要架构,重点分析了时间噪声和空间噪声的来源和影响,并给出低噪声设计指导。同时对线性度、动态范围和帧频等主要性能进行了讨...红外焦平面的数字读出是信息化发展的必然方向,其关键技术是数字读出电路。介绍了数字读出电路的发展现状和主要架构,重点分析了时间噪声和空间噪声的来源和影响,并给出低噪声设计指导。同时对线性度、动态范围和帧频等主要性能进行了讨论,设计了两款数字读出电路。采用列级ADC数字读出架构设计了640×512数字焦平面探测器读出电路,读出噪声测试结果为150μV,互连中波探测器测试NETD为13 m K。基于数字像元读出架构设计了384×288数字焦平面探测器读出电路,互连长波探测器测试NETD小于4 m K,动态范围超过90 dB,帧频达到1000 Hz。所设计的两款读出电路有效提升了红外焦平面的灵敏度、动态范围和帧频等性能,表明数字读出电路技术对红外探测器性能的提升具有重要作用。展开更多
文摘In recent years,deep learning has been introduced into the field of Single-pixel imaging(SPI),garnering significant attention.However,conventional networks still exhibit limitations in preserving image details.To address this issue,we integrate Large Kernel Convolution(LKconv)into the U-Net framework,proposing an enhanced network structure named U-LKconv network,which significantly enhances the capability to recover image details even under low sampling conditions.
文摘目的:探讨玫瑰痤疮患者采用低能量Pixel调Q像束激光与米诺环素联合治疗后红斑情况及面部功能改善情况。方法:研究对象选自于2020年3月-2023年7月在上海交通大学医学院苏州九龙医院接受治疗的玫瑰痤疮患者110例,并分为对照组和观察组,每组例数均为55例,分组方法为随机数字表法。对照组给予盐酸米诺环素片,在对照组患者治疗的基础上,采用低能量Pixel调Q像束激光对观察组患者进行治疗。两组治疗时间均为6周。比较两组临床疗效(治疗6周后),玫瑰痤疮情况、整体病情、p38丝裂原活化蛋白激酶(p38 mitogen activated protein kinase,p38MAPK)通路蛋白、生活质量、红斑情况、面部功能、炎性因子(治疗前、治疗6周后),不良反应(治疗期间)。结果:治疗6周后,观察组总有效率高于对照组(76.36%vs.54.55%,P<0.05)。与治疗前比较,两组治疗6周后的玫瑰痤疮医师全球评分(Patient's global assessment,PGA)、整体病情评估(Investigator global assessment,IGA)、皮肤病生活质量量表(Dermatology life quality index,DLQI)评分、红斑评估量表(Clinician′s erythema assessment,CEA)评分、皮损区红斑指数(Erythema index,EI)、经皮水分丢失(Trans epidermal water loss,TEWL)、皮肤酸碱度(Pondus Hydrogenii,pH)值、炎性因子及p38MAPK通路蛋白相关因子水平均降低,且相比于对照组,观察组更低;两组角质层含水量均升高,且相比于对照组,观察组更高(P<0.05)。观察组和对照组治疗期间的不良反应发生率比较差异无统计学意义(P>0.05)。结论:玫瑰痤疮患者经低能量Pixel调Q像束激光联合米诺环素治疗后,其相关临床症状可得到有效缓解,炎症反应得以减轻,并可调节p38MAPK信号通路蛋白的表达,进一步可促进患者红斑情况及面部功能的改善,进而促使患者生活质量及临床疗效得以提高,且具有良好的安全性。
基金supported by the National Natural Science Foundation of China,No.31070758,31271060the Natural Science Foundation of Chongqing in China,No.cstc2013jcyj A10085
文摘Visual cortical prostheses have the potential to restore partial vision. Still limited by the low-resolution visual percepts provided by visual cortical prostheses, implant wearers can currently only ＂see＂ pixelized images, and how to obtain the specific brain responses to different pixelized images in the primary visual cortex（the implant area） is still unknown. We conducted a functional magnetic resonance imaging experiment on normal human participants to investigate the brain activation patterns in response to 18 different pixelized images. There were 100 voxels in the brain activation pattern that were selected from the primary visual cortex, and voxel size was 4 mm × 4 mm × 4 mm. Multi-voxel pattern analysis was used to test if these 18 different brain activation patterns were specific. We chose a Linear Support Vector Machine（LSVM） as the classifier in this study. The results showed that the classification accuracies of different brain activation patterns were significantly above chance level, which suggests that the classifier can successfully distinguish the brain activation patterns. Our results suggest that the specific brain activation patterns to different pixelized images can be obtained in the primary visual cortex using a 4 mm × 4 mm × 4 mm voxel size and a 100-voxel pattern.
文摘目的:观察低能量Pixel调Q像束激光联合盐酸米诺环素治疗玫瑰痤疮安全性和疗效。方法:选取某三甲医院门诊收治的玫瑰痤疮患者100例,按照随机数字法分为药物治疗组(32例)、激光治疗组(34例)与联合组(34例),药物治疗组采用单独盐酸米诺环素治疗,每晚1次,100 mg口服,连续治疗6周;激光治疗组采用低能量Pixel调Q像束激光治疗,2周1次,连续6周;联合组采用低能量Pixel调Q像束激光联合盐酸米诺环素100 mg口服每晚1次,连续6周治疗。治疗结束后比较3组患者整体病情的评估(investigator’s global assessment,IGA)。结果:治疗前3组患者IGA评分差异无统计学意义,治疗结束后,联合组患者整体病情评估IGA评分、症状积分均较2个对照组改善明显(P<0.01)。结论:低能量Pixel调Q像束激光联合米诺环素治疗玫瑰痤疮效果良好,不良反应少。
文摘红外焦平面的数字读出是信息化发展的必然方向,其关键技术是数字读出电路。介绍了数字读出电路的发展现状和主要架构,重点分析了时间噪声和空间噪声的来源和影响,并给出低噪声设计指导。同时对线性度、动态范围和帧频等主要性能进行了讨论,设计了两款数字读出电路。采用列级ADC数字读出架构设计了640×512数字焦平面探测器读出电路,读出噪声测试结果为150μV,互连中波探测器测试NETD为13 m K。基于数字像元读出架构设计了384×288数字焦平面探测器读出电路,互连长波探测器测试NETD小于4 m K,动态范围超过90 dB,帧频达到1000 Hz。所设计的两款读出电路有效提升了红外焦平面的灵敏度、动态范围和帧频等性能,表明数字读出电路技术对红外探测器性能的提升具有重要作用。
