Shannon channel capacity theorem poses highest bit-rate of error free transmission over additive white Gaussian noise channel.In addition,he proved that there exists channel code that can theoretically achieve the cha...Shannon channel capacity theorem poses highest bit-rate of error free transmission over additive white Gaussian noise channel.In addition,he proved that there exists channel code that can theoretically achieve the channel capacity.Indeed fortunately,the latter researchers found some practical channel codes approaching the channel capacity with insignificant losses of spectral efficiency under ignorable bit error rate(BER).The authors note,in general,that bits of the channel codes are not independent of each other in code space.Further,we note that the modulated symbols are not independent among them,as well,in Euclidean Space.By exploiting a usage of the dependencies jointly to signal design,we can transmit two independent signal streams through an additive white Gaussian channel and separate them in Euclidean space at the receiver.The capacity of this approach is found larger than that of Shannon capacity in the same channel assumptions.The numerical results confirm the theoretical procedures.展开更多
Biomolecular condensation, driven by multivalency, serves as a fundamental mechanism within cells, facilitating the formation of distinct compartments, including membraneless organelles that play essential roles in va...Biomolecular condensation, driven by multivalency, serves as a fundamental mechanism within cells, facilitating the formation of distinct compartments, including membraneless organelles that play essential roles in various cellular processes. Perturbations in the delicate equilibrium of condensation, whether resulting in gain or loss of phase separation, have robustly been associated with cellular dysfunction and physiological disorders. As ongoing research endeavors wholeheartedly embrace this newly acknowledged principle, a transformative shift is occurring in our comprehension of disease. Consequently, significant strides have been made in unraveling the profound relevance and potential causal connections between abnormal phase separation and various diseases. This comprehensive review presents compelling recent evidence that highlight the intricate associations between aberrant phase separation and neurodegenerative diseases, cancers, and infectious diseases. Additionally, we provide a succinct summary of current efforts and propose innovative solutions for the development of potential therapeutics to combat the pathological consequences attributed to aberrant phase separation.展开更多
Urban Air Mobility(UAM)is an emerging aviation sector which the goal is to transform air transportation with safe,on-demand air travel for both passengers and cargo.UAM flight planning strategically separates flows of...Urban Air Mobility(UAM)is an emerging aviation sector which the goal is to transform air transportation with safe,on-demand air travel for both passengers and cargo.UAM flight planning strategically separates flows of aircraft on intersecting routes vertically by allocating distinct flight levels to them,and aircraft are required to maintain the flight level when crossing the intersection.However,there is a possibility that an aircraft may fail to maintain the assigned flight level,leading to a potential conflict at intersections.This paper aims to address conflicts at intersections in the context of UAM,focusing on decentralized conflict detection and resolution.A novel approach is developed to facilitate information exchange among UAM components,including the provider of services to UAM,UAM operators,and the pilot in command.A receding horizon trajectory planning approach is proposed for the execution of conflict resolution,optimizing trajectory planning by eliminating potential problems and challenges associated with geometric approaches.The proposed trajectory planner considers the model and constraints of UAM aircraft,offering optimal solutions for safe separation at UAM airspace intersections.The significance of the proposed planning framework is demonstrated through simulations considering conflict at intersections by communicating the UAM components through request and replay services and generating resolution maneuvers on-the-fly for each aircraft involved in the conflict.展开更多
基金supported by two Programs of National Natural Science Foundation of China(No.61271203 and No.61531004)
文摘Shannon channel capacity theorem poses highest bit-rate of error free transmission over additive white Gaussian noise channel.In addition,he proved that there exists channel code that can theoretically achieve the channel capacity.Indeed fortunately,the latter researchers found some practical channel codes approaching the channel capacity with insignificant losses of spectral efficiency under ignorable bit error rate(BER).The authors note,in general,that bits of the channel codes are not independent of each other in code space.Further,we note that the modulated symbols are not independent among them,as well,in Euclidean Space.By exploiting a usage of the dependencies jointly to signal design,we can transmit two independent signal streams through an additive white Gaussian channel and separate them in Euclidean space at the receiver.The capacity of this approach is found larger than that of Shannon capacity in the same channel assumptions.The numerical results confirm the theoretical procedures.
基金National Key Research and Development Program of China(2019YFA0508403 to P.L.)National Natural Science Foundation of China(32330024 to P.L.,32100547 to M.R.,and 32100990 to W.F.).
文摘Biomolecular condensation, driven by multivalency, serves as a fundamental mechanism within cells, facilitating the formation of distinct compartments, including membraneless organelles that play essential roles in various cellular processes. Perturbations in the delicate equilibrium of condensation, whether resulting in gain or loss of phase separation, have robustly been associated with cellular dysfunction and physiological disorders. As ongoing research endeavors wholeheartedly embrace this newly acknowledged principle, a transformative shift is occurring in our comprehension of disease. Consequently, significant strides have been made in unraveling the profound relevance and potential causal connections between abnormal phase separation and various diseases. This comprehensive review presents compelling recent evidence that highlight the intricate associations between aberrant phase separation and neurodegenerative diseases, cancers, and infectious diseases. Additionally, we provide a succinct summary of current efforts and propose innovative solutions for the development of potential therapeutics to combat the pathological consequences attributed to aberrant phase separation.
基金support from the NASA University Leadership Initiative(ULI)under agreement number 2 CFR 200.514 Grant Number 80NSSC20M0161the U.S.Department of Transportation(USDOT)University Transportation Program(UTC)under Grant No.69A3552348304.
文摘Urban Air Mobility(UAM)is an emerging aviation sector which the goal is to transform air transportation with safe,on-demand air travel for both passengers and cargo.UAM flight planning strategically separates flows of aircraft on intersecting routes vertically by allocating distinct flight levels to them,and aircraft are required to maintain the flight level when crossing the intersection.However,there is a possibility that an aircraft may fail to maintain the assigned flight level,leading to a potential conflict at intersections.This paper aims to address conflicts at intersections in the context of UAM,focusing on decentralized conflict detection and resolution.A novel approach is developed to facilitate information exchange among UAM components,including the provider of services to UAM,UAM operators,and the pilot in command.A receding horizon trajectory planning approach is proposed for the execution of conflict resolution,optimizing trajectory planning by eliminating potential problems and challenges associated with geometric approaches.The proposed trajectory planner considers the model and constraints of UAM aircraft,offering optimal solutions for safe separation at UAM airspace intersections.The significance of the proposed planning framework is demonstrated through simulations considering conflict at intersections by communicating the UAM components through request and replay services and generating resolution maneuvers on-the-fly for each aircraft involved in the conflict.
