Fast radio bursts(FRBs)are extremely energetic,millisecond-duration flashes of radio waves that represent one of the most intriguing phenomena in astronomy.Their cosmological distances,immense energy outputs,and poten...Fast radio bursts(FRBs)are extremely energetic,millisecond-duration flashes of radio waves that represent one of the most intriguing phenomena in astronomy.Their cosmological distances,immense energy outputs,and potential links to other high-energy astrophysical events make them particularly valuable for probing a wide range of fundamental physics(e.g.,ref.[1]).展开更多
目的评价符合入排条件的接受EFV+3TC+TDF方案的HIV-1感染者转换为艾诺米替(艾诺韦林/拉米夫定/替诺福韦,ANV/3TC/TDF)治疗144周,以及EFV+3TC+TDF转换艾考恩丙替(艾维雷韦/考比司他/恩曲他滨/丙酚替诺福韦,EVG/c/FTC/TAF)治疗48周后,继...目的评价符合入排条件的接受EFV+3TC+TDF方案的HIV-1感染者转换为艾诺米替(艾诺韦林/拉米夫定/替诺福韦,ANV/3TC/TDF)治疗144周,以及EFV+3TC+TDF转换艾考恩丙替(艾维雷韦/考比司他/恩曲他滨/丙酚替诺福韦,EVG/c/FTC/TAF)治疗48周后,继续转换为ANV/3TC/TDF治疗至144周的有效性和代谢安全性。方法本研究为SPRINT(Switching people with HIV to receive innovative NNRTI-based therapy)研究的拓展性用药研究,将研究对象分为即刻转换组(指ANV/3TC/TDF自基线治疗至第144周)和延迟转换组(指EVG/c/FTC/TAF自基线治疗48周后,转换为ANV/3TC/TDF治疗至第144周)。研究的有效性终点为治疗144周时HIV-1病毒得到抑制的研究对象百分比,代谢安全性结局包括低密度脂蛋白胆固醇(LDL-C)、动脉粥样硬化性心血管疾病(ASCVD)风险相关LDL-C分层,估计肾小球滤过率(eGFR)用于评估肾功能安全性。结果研究共纳入731例研究对象,其中即刻转换组370例,延迟转换组361例。治疗144周时,即刻转换组与延迟转换组的研究对象病毒学抑制百分比分别为95.3%与95%,两组的CD4细胞计数自48周到144周分别上升(70.9±8.7)与(64.4±9.7)个/μL。延迟转换组的LDL-C值由于经历了0到48周上升过程,在48到144周时的降幅显著大于即刻转换组(-0.44±0.03 vs.-0.06±0.03 mmol/L,P<0.001),两组LDL-C高风险分层百分比自基线到144周分别下降60.0%和78.1%。治疗144周时两组eGFR值分别为(109.1±20.4)mL/min/1.73 m^(2)与(106.3±13.9)mL/min/1.73 m^(2),组间差异无统计学意义(P>0.05)。结论EFV为核心的cART方案以及含TAF的整合酶抑制剂(INSTIs)方案转换为ANV/3TC/TDF均可实现持续病毒学抑制,同时持续改善LDL-C水平及ASCVD风险分层。由含TAF的INSTIs方案转换为ANV/3TC/TDF方案后,可显著降低LDL-C异常的研究对象比例。展开更多
BACKGROUND The concept of“duodenal-type follicular lymphoma(FL)”has already been established as a disease entity.On the other hand,because FL that develops in the colorectum is a rare disease,its clinical characteri...BACKGROUND The concept of“duodenal-type follicular lymphoma(FL)”has already been established as a disease entity.On the other hand,because FL that develops in the colorectum is a rare disease,its clinical characteristics,including its treatment and outcome,are poorly understood.AIM To clarify the characteristic clinical features of colorectal FL.METHODS We identified 5 patients with FL from December 2010 to July 2022 whose colorectal lesions were confirmed by endoscopic biopsy at our hospital and retrospectively examined their clinical features,including endoscopic findings,treatment,and long-term outcomes.RESULTS The median age of the patients was 70 years(range 62-74 years,3 males and 2 females),and 2 patients were considered to have systemic FL lesions.Endoscopic findings revealed elavated lesions in all 5 patients(polypoid 3,flat elavated 1,papular 1).Only 1 patient underwent therapeutic intervention,and 4 patients chose watchful waiting.Except for 1 patient in which the lesion spontaneously regressed,the disease recurred or progressed in 4 patients,3 of whom eventually achieved near complete remission with the administration of rituximab and bendamustine(±polatuzumab vedotin).The 5 patients in this study were still alive or exhibited long-term survival before death;the survival time ranged from 8-29 years after the onset of lymphoma.CONCLUSION In the present study,colorectal FL progressed slowly,and overall survival was good because it was sensitive to anticancer drugs even after the disease progressed without initial therapeutic intervention.展开更多
BACKGROUND Serous carcinoma of the uterine cervix(USCC)represents a rare subtype of cervical adenocarcinoma,classified into human papillomavirus(HPV)-independent and HPV-associated types.It is characterized by high in...BACKGROUND Serous carcinoma of the uterine cervix(USCC)represents a rare subtype of cervical adenocarcinoma,classified into human papillomavirus(HPV)-independent and HPV-associated types.It is characterized by high invasiveness and poor prognosis,with limited global reports on this condition.CASE SUMMARY A 58-year-old Chinese woman presented with painless vaginal bleeding after sexual intercourse,which appeared as droplets.HPV testing and histopathological analysis confirmed the diagnosis of HPV-associated primary serous carcinoma of the USCC.The patient underwent radical hysterectomy and was diagnosed with primary serous carcinoma of the uterine cervix,stage III C2(FIGO 2018).A multimodal treatment approach,including surgery,radiotherapy,and chemotherapy,was administered.After additional concurrent chemoradiotherapy and three cycles of chemotherapy,the patient showed no evidence of disease progression and achieved long-term survival for 53 months.CONCLUSION USCC is a rare and aggressive malignancy.Upon diagnosis,multimodal treatment strategies,including surgery,radiotherapy,and chemotherapy,can effectively prolong patient survival and improve prognosis.展开更多
Introduction:In recent years,significant advancements in the treatment of metastatic renal cell carcinoma(mRCC)have notably extended overall survival(OS)times,particularly with the introduction of tyrosine kinase inhi...Introduction:In recent years,significant advancements in the treatment of metastatic renal cell carcinoma(mRCC)have notably extended overall survival(OS)times,particularly with the introduction of tyrosine kinase inhibitors(TKIs)and combination immunotherapy.However,survival outcomes in mRCC remain highly variable.Materials and Methods:This study retrospectively analyzed clinical and demographic factors at diagnosis in patients treated for mRCC to identify predictors of long-term survival(defined as OS≥48 months).Patients were categorized into long-term survivors(LTS)and non-long-term survivors(nLTS).Results:The analysis revealed that factors such as better Karnofsky Performance Status(KPS),normal baseline laboratory values(e.g.,hemoglobin,calcium),and the presence of lung-only metastases were significantly associated with longer survival.Conversely,comorbid conditions like hypertension and dyslipidemia,poorer KPS,and certain adverse laboratory findings were more common in the nLTS group.Conclusion:These findings underscore the importance of baseline prognostic factors in predicting survival outcomes and emphasize the need for personalized treatment strategies in mRCC.展开更多
有机-无机杂化钙钛矿太阳能电池(perovskite solar cell, PSC)具有光电转换效率潜力高、成本低、可叠层、可柔性四大核心优势,已成为当前光伏领域的研究热点。经过十余年发展,其认证光电转换效率已达27.0%。围绕有机-无机杂化钙钛矿太...有机-无机杂化钙钛矿太阳能电池(perovskite solar cell, PSC)具有光电转换效率潜力高、成本低、可叠层、可柔性四大核心优势,已成为当前光伏领域的研究热点。经过十余年发展,其认证光电转换效率已达27.0%。围绕有机-无机杂化钙钛矿太阳能电池的大面积制备工艺、柔性钙钛矿电池、钙钛矿/晶硅叠层电池的研究进展,以及有机-无机钙钛矿太阳能电池的稳定性提升策略展开讨论,旨在为有机-无机杂化钙钛矿太阳能电池的产业化发展提供有益的参考。展开更多
文摘Fast radio bursts(FRBs)are extremely energetic,millisecond-duration flashes of radio waves that represent one of the most intriguing phenomena in astronomy.Their cosmological distances,immense energy outputs,and potential links to other high-energy astrophysical events make them particularly valuable for probing a wide range of fundamental physics(e.g.,ref.[1]).
文摘目的评价符合入排条件的接受EFV+3TC+TDF方案的HIV-1感染者转换为艾诺米替(艾诺韦林/拉米夫定/替诺福韦,ANV/3TC/TDF)治疗144周,以及EFV+3TC+TDF转换艾考恩丙替(艾维雷韦/考比司他/恩曲他滨/丙酚替诺福韦,EVG/c/FTC/TAF)治疗48周后,继续转换为ANV/3TC/TDF治疗至144周的有效性和代谢安全性。方法本研究为SPRINT(Switching people with HIV to receive innovative NNRTI-based therapy)研究的拓展性用药研究,将研究对象分为即刻转换组(指ANV/3TC/TDF自基线治疗至第144周)和延迟转换组(指EVG/c/FTC/TAF自基线治疗48周后,转换为ANV/3TC/TDF治疗至第144周)。研究的有效性终点为治疗144周时HIV-1病毒得到抑制的研究对象百分比,代谢安全性结局包括低密度脂蛋白胆固醇(LDL-C)、动脉粥样硬化性心血管疾病(ASCVD)风险相关LDL-C分层,估计肾小球滤过率(eGFR)用于评估肾功能安全性。结果研究共纳入731例研究对象,其中即刻转换组370例,延迟转换组361例。治疗144周时,即刻转换组与延迟转换组的研究对象病毒学抑制百分比分别为95.3%与95%,两组的CD4细胞计数自48周到144周分别上升(70.9±8.7)与(64.4±9.7)个/μL。延迟转换组的LDL-C值由于经历了0到48周上升过程,在48到144周时的降幅显著大于即刻转换组(-0.44±0.03 vs.-0.06±0.03 mmol/L,P<0.001),两组LDL-C高风险分层百分比自基线到144周分别下降60.0%和78.1%。治疗144周时两组eGFR值分别为(109.1±20.4)mL/min/1.73 m^(2)与(106.3±13.9)mL/min/1.73 m^(2),组间差异无统计学意义(P>0.05)。结论EFV为核心的cART方案以及含TAF的整合酶抑制剂(INSTIs)方案转换为ANV/3TC/TDF均可实现持续病毒学抑制,同时持续改善LDL-C水平及ASCVD风险分层。由含TAF的INSTIs方案转换为ANV/3TC/TDF方案后,可显著降低LDL-C异常的研究对象比例。
文摘BACKGROUND The concept of“duodenal-type follicular lymphoma(FL)”has already been established as a disease entity.On the other hand,because FL that develops in the colorectum is a rare disease,its clinical characteristics,including its treatment and outcome,are poorly understood.AIM To clarify the characteristic clinical features of colorectal FL.METHODS We identified 5 patients with FL from December 2010 to July 2022 whose colorectal lesions were confirmed by endoscopic biopsy at our hospital and retrospectively examined their clinical features,including endoscopic findings,treatment,and long-term outcomes.RESULTS The median age of the patients was 70 years(range 62-74 years,3 males and 2 females),and 2 patients were considered to have systemic FL lesions.Endoscopic findings revealed elavated lesions in all 5 patients(polypoid 3,flat elavated 1,papular 1).Only 1 patient underwent therapeutic intervention,and 4 patients chose watchful waiting.Except for 1 patient in which the lesion spontaneously regressed,the disease recurred or progressed in 4 patients,3 of whom eventually achieved near complete remission with the administration of rituximab and bendamustine(±polatuzumab vedotin).The 5 patients in this study were still alive or exhibited long-term survival before death;the survival time ranged from 8-29 years after the onset of lymphoma.CONCLUSION In the present study,colorectal FL progressed slowly,and overall survival was good because it was sensitive to anticancer drugs even after the disease progressed without initial therapeutic intervention.
基金Supported by the Sichuan Science and Technology Program,No.2022NSFSC0797.
文摘BACKGROUND Serous carcinoma of the uterine cervix(USCC)represents a rare subtype of cervical adenocarcinoma,classified into human papillomavirus(HPV)-independent and HPV-associated types.It is characterized by high invasiveness and poor prognosis,with limited global reports on this condition.CASE SUMMARY A 58-year-old Chinese woman presented with painless vaginal bleeding after sexual intercourse,which appeared as droplets.HPV testing and histopathological analysis confirmed the diagnosis of HPV-associated primary serous carcinoma of the USCC.The patient underwent radical hysterectomy and was diagnosed with primary serous carcinoma of the uterine cervix,stage III C2(FIGO 2018).A multimodal treatment approach,including surgery,radiotherapy,and chemotherapy,was administered.After additional concurrent chemoradiotherapy and three cycles of chemotherapy,the patient showed no evidence of disease progression and achieved long-term survival for 53 months.CONCLUSION USCC is a rare and aggressive malignancy.Upon diagnosis,multimodal treatment strategies,including surgery,radiotherapy,and chemotherapy,can effectively prolong patient survival and improve prognosis.
文摘Introduction:In recent years,significant advancements in the treatment of metastatic renal cell carcinoma(mRCC)have notably extended overall survival(OS)times,particularly with the introduction of tyrosine kinase inhibitors(TKIs)and combination immunotherapy.However,survival outcomes in mRCC remain highly variable.Materials and Methods:This study retrospectively analyzed clinical and demographic factors at diagnosis in patients treated for mRCC to identify predictors of long-term survival(defined as OS≥48 months).Patients were categorized into long-term survivors(LTS)and non-long-term survivors(nLTS).Results:The analysis revealed that factors such as better Karnofsky Performance Status(KPS),normal baseline laboratory values(e.g.,hemoglobin,calcium),and the presence of lung-only metastases were significantly associated with longer survival.Conversely,comorbid conditions like hypertension and dyslipidemia,poorer KPS,and certain adverse laboratory findings were more common in the nLTS group.Conclusion:These findings underscore the importance of baseline prognostic factors in predicting survival outcomes and emphasize the need for personalized treatment strategies in mRCC.
文摘有机-无机杂化钙钛矿太阳能电池(perovskite solar cell, PSC)具有光电转换效率潜力高、成本低、可叠层、可柔性四大核心优势,已成为当前光伏领域的研究热点。经过十余年发展,其认证光电转换效率已达27.0%。围绕有机-无机杂化钙钛矿太阳能电池的大面积制备工艺、柔性钙钛矿电池、钙钛矿/晶硅叠层电池的研究进展,以及有机-无机钙钛矿太阳能电池的稳定性提升策略展开讨论,旨在为有机-无机杂化钙钛矿太阳能电池的产业化发展提供有益的参考。
