We developed L3SN, a scalable, longevous, adaptive, and internet accessible wireless sensor network system for agriculture information monitoring, which is meticulously designed to meet the requirement of thousands he...We developed L3SN, a scalable, longevous, adaptive, and internet accessible wireless sensor network system for agriculture information monitoring, which is meticulously designed to meet the requirement of thousands hectares coverage, years of time monitoring and the adverse environment. The system architecture, the agriculture sensor device, the mesh protocol, and the web-based information processing platform are introduced. We also presented some implementation experience. The mesh protocol (LayerMesh) is highlighted, in which “stair scheduling” and “distributed dynamic load-balancing” are proposed to response the scalability, longevity and adaptivity requirements. We believe the design of L3SN is useful to many other large-scale, longevous applications such as hydrologic monitoring, geological monitoring etc.展开更多
Spinel LiMn_(2)O_(4)(LMO)is deemed to be a promising cathode material for commercial lithium-ion batteries(LIBs)in prospect of its cost-effectiveness,nontoxicity,fabulous rate capability,and high energy density.Nevert...Spinel LiMn_(2)O_(4)(LMO)is deemed to be a promising cathode material for commercial lithium-ion batteries(LIBs)in prospect of its cost-effectiveness,nontoxicity,fabulous rate capability,and high energy density.Nevertheless,the LMO is inevitably confronted with sluggish diffusion kinetics and drastic capacity degradation triggered by multiple issues,including Jahn-Teller distortion,Mn dissolution,and structural attenuation.Thereinto,a metal-organic framework(MOF)chemistry engineering for hierarchical micro-/nano-structural F,O-dual-doped carbon embedded oxygen vacancy enriched LiMn_(2)O_(4)cathode(OV-LMO@FOC)is proposed for longevous LIBs.Bestowed by experimental and theoretical implementations,systematic investigations of OV-LMO@FOC endow that the meticulous integration of F,O-dual-doped carbon and oxygen vacancy in LMO-based cathode reconfigures the electronic structure,boosts electronic conductivity,expedites diffusion capability,facilitates energetically preferable Li^(+) adsorption,and suppresses Mn dissolution in the electrolyte,consequently achieving fabulous long-term cycling stability.As expected,the OV-LMO@FOC behaves with compelling electrochemical performance with prosperous reversible capacity(130.2 mAh g^(−1)at 0.2 C upon 200 cycles),exceptional rate capacity(93.7 mAh g^(−1) even at 20 C),and pronounced long-term cyclability(112.5 mAh g^(−1)after 1200 cycles with 77.6%capacity retention at 1 C).Even at the ultrahigh current density of 5 C,the OV-LMO@FOC bears a brilliant capacity of 96.9 mAh g^(−1)upon 1000 cycles with an extraordinary capacity retention of 90.7%,and maintains a discharge capacity of 70.9 mAh g^(−1)upon 4000 cycles.This work envisions the MOF-chemistry in surface modification and electronic modulation engineering of high-performance cathode materials towards industrialization in automotive market.展开更多
Background Sow longevity and reproductivity are essential in the modern swine industry.Although many studies have focused on the genetic and genomic factors for selection,little is known about the associations between...Background Sow longevity and reproductivity are essential in the modern swine industry.Although many studies have focused on the genetic and genomic factors for selection,little is known about the associations between the microbiome and sows with longevity in reproduction.Results In this study,we collected and sequenced rectal and vaginal swabs from 48 sows,nine of which completed up to four parities(U4P group),exhibiting reproductive longevity.We first identified predictors of sow longevity in the rectum(e.g.,Akkermansia)and vagina(e.g.,Lactobacillus)of the U4P group using RandomForest in the early breeding stage of the first parity.Interestingly,these bacteria in the U4P group showed decreased predicted KEGG gene abundance involved in the biosynthesis of amino acids.Then,we tracked the longitudinal changes of the micro-biome over four parities in the U4P sows.LEfSe analysis revealed parity-associated bacteria that existed in both the rectum and vagina(e.g.,Streptococcus in Parity 1,Lactobacillus in Parity 2,Veillonella in Parity 4).We also identi-fied patterns of bacterial change between the early breeding stage(d 0)and d 110,such as Streptococcus,which was decreased in all four parties.Furthermore,sows in the U4P group with longevity potential also showed better reproductive performance.Finally,we discovered bacterial predictors(e.g.,Prevotellaceae NK3B31 group)for the total number of piglets born throughout the four parities in both the rectum and vagina.Conclusions This study highlights how the rectal and vaginal microbiome in sows with longevity in reproduc-tion changes within four parities.The identification of parity-associated,pregnancy-related,and reproductive performance-correlated bacteria provides the foundation for targeted microbiome modulation to improve animal production.展开更多
Anti-aging research has become a popular scientific field with the increasing prominence of population aging.Rare ginsenoside Compound K(CK)has attracted widespread attention as an emerging anti-aging active ingredien...Anti-aging research has become a popular scientific field with the increasing prominence of population aging.Rare ginsenoside Compound K(CK)has attracted widespread attention as an emerging anti-aging active ingredient.The anti-aging effect of ginsenosides is considered to be one of the important roles of ginsenosides,and Compound K,as the main deglycosylated metabolite of ginsenosides,has a comprehensive anti-aging effect as a highly active ingredient obtained by transformation under the action of microbiota.Recent studies have shown that ginsenosides have anti-photo-oxidation,anti-skin aging,free radical scavenging and immunostimulatory effects,which can effectively prevent skin photoaging.With the progress of modern natural medicine extraction technology and the deepening of the research on the anti-skin aging of ginsenosides'high active ingredients,it will promote the development and application of natural product protective skin photoaging preparations.The rare ginsenoside Compound K plays an important role in the improvement of skin health and anti-aging,which is mainly realized by increasing the activity of antioxidant enzymes,inducing the expression of related genes,reducing the content of oxidative damage substances,regulating the immune system,and influencing the expression of cell-cycle regulators and aging genes.A more comprehensive and in-depth study of the molecular mechanism of the anti-aging effect of rare ginsenoside Compound K will be one of the focuses of future research.展开更多
Since ancient times,humanity has yearned for longevity,viewing health and long life as enduring aspirations.Research has shown that longevity genes may be passed down through certain populations(Costa D,2019).However,...Since ancient times,humanity has yearned for longevity,viewing health and long life as enduring aspirations.Research has shown that longevity genes may be passed down through certain populations(Costa D,2019).However,genetics alone is not the decisive factor-environmental conditions also play a vital role in achieving a long life(Selinus O,2013).展开更多
Ten Thousand Years of Life.Chief Director:Zhou Xiaomeng.Length:12 Episodes.Producers:Hunan TV,Mango TV,and OBM.Broadcasting Platforms:Mango TV,and bilibili.In the backdrop of China’s aging society,this film series fo...Ten Thousand Years of Life.Chief Director:Zhou Xiaomeng.Length:12 Episodes.Producers:Hunan TV,Mango TV,and OBM.Broadcasting Platforms:Mango TV,and bilibili.In the backdrop of China’s aging society,this film series focuses on the community of elderly people in China who have enjoyed longevity.展开更多
Secondary aging is characterized by nine cellular and molecular hallmarks including genomic instability,telomere attrition,epigenetic alterations,loss of proteostasis,deregulated nutrient sensing,mitochondrial dysfunc...Secondary aging is characterized by nine cellular and molecular hallmarks including genomic instability,telomere attrition,epigenetic alterations,loss of proteostasis,deregulated nutrient sensing,mitochondrial dysfunction,cellular senescence,stem cell exhaustion,and altered intercellular communication.Exercise might be a uniquely valid intervention that can effectively promote healthy aging and attenuate age-related diseases without any side effects.On the molecular mechanism,exercise can effectively arrest all of the nine hallmarks of aging mentioned above.This review describes the mechanisms by which exercise can ameliorate these processes of aging.展开更多
Landslide dam failures can cause significant damage to both society and ecosystems.Predicting the failure of these dams in advance enables early preventive measures,thereby minimizing potential harm.This paper aims to...Landslide dam failures can cause significant damage to both society and ecosystems.Predicting the failure of these dams in advance enables early preventive measures,thereby minimizing potential harm.This paper aims to propose a fast and accurate model for predicting the longevity of landslide dams while also addressing the issue of missing data.Given the wide variation in the survival times of landslide dams—from mere minutes to several thousand years—predicting their longevity presents a considerable challenge.The study develops predictive models by considering key factors such as dam geometry,hydrodynamic conditions,materials,and triggering parameters.A dataset of 1045 landslide dam cases is analyzed,categorizing their longevity into three distinct groups:C1(<1 month),C2(1 month to 1 year),and C3(>1 year).Multiple imputation and knearest neighbor algorithms are used to handle missing data on geometric size,hydrodynamic conditions,materials,and triggers.Based on the imputed data,two predictive models are developed:a classification model for dam longevity categories and a regression model for precise longevity predictions.The classification model achieves an accuracy of 88.38%while the regression model outperforms existing models with an R^(2) value of 0.966.Two real-life landslide dam cases are used to validate the models,which show correct classification and small prediction errors.The longevity of landslide dams is jointly influenced by factors such as geometric size,hydrodynamic conditions,materials,and triggering events.Among these,geometric size has the greatest impact,followed by hydrodynamic conditions,materials,and triggers,as confirmed by variable importance in the model development.展开更多
Emitting alarm calls may be costly,but few studies have asked whether calling increases a caller’s risk of predation and survival.Since observing animals calling and being killed is relatively rare,we capitalized on ...Emitting alarm calls may be costly,but few studies have asked whether calling increases a caller’s risk of predation and survival.Since observing animals calling and being killed is relatively rare,we capitalized on over 24,000 h of observations of marmot colonies and asked whether variation in the rate that yellow-bellied marmots(Marmota faviventer)alarm called was associated with the probability of summer mortality,a proxy for predation.Using a generalized mixed model that controlled for factors that infuenced the likelihood of survival,we found that marmots who called at higher rates were substantially more likely to die over the summer.Because virtually all summer mortality is due to predation,these results suggest that calling is indeed costly for marmots.Additionally,the results from a Cox survival analysis showed that marmots that called more lived signifcantly shorter lives.Prior studies have shown that marmots reduce the risk by emitting calls only when close to their burrows,but this newly quantifed survival cost suggests a constraint on eliminating risks.Quantifying the cost of alarm calling using a similar approach in other systems will help us better understand its true costs,which is an essential value for theoretical models of calling and social behavior.展开更多
In Chinese tradition,the term“耄耋”(Mào Dié)refers to those in their nineties,a stage of life associated with wisdom and longevity.As the Bank of China Singapore Branch(BOCSG)approaches its 90th anniversar...In Chinese tradition,the term“耄耋”(Mào Dié)refers to those in their nineties,a stage of life associated with wisdom and longevity.As the Bank of China Singapore Branch(BOCSG)approaches its 90th anniversary,this expression captures the spirit of an institution that has stood the test of time.Since its establishment in Singapore in 1936,the BOCSG has maintained a strong and enduring presence not only in Singapore but across Southeast Asia,serving as a bridge between China and Singapore,and more broadly,between China and the ASEAN region.Its continued growth has been underpinned by the mutual prosperity of both economies and the strength of their longstanding and harmonious ties.展开更多
The lining materials for blast furnaces have evolved from brick masonry to monolithic refractory materials.Monolithic castables are widely used in various industrial furnaces.The rapid development of silica sol materi...The lining materials for blast furnaces have evolved from brick masonry to monolithic refractory materials.Monolithic castables are widely used in various industrial furnaces.The rapid development of silica sol materials,combined with the commonly used construction methods of casting and spraying,offers greater flexibility,efficiency,environmental friendliness,and a longer lifespan.Typical monolithic refractory technologies,such as the integral casting technique for the furnace hearth,the pre-applied slag coating technique for the furnace belly and waist,and the inner lining gunning technique,are grounded in scientific theory and practice,thereby advancing the development of refractory materials and enhancing the operational quality of blast furnaces.展开更多
Over the past three decades,micro/nano science and technology have experienced rapid advancements as new materials and advanced devices have increasingly evolved towards high levels of integration and miniaturization....Over the past three decades,micro/nano science and technology have experienced rapid advancements as new materials and advanced devices have increasingly evolved towards high levels of integration and miniaturization.In this context,mechanical properties have emerged as critical parameters for evaluating the operational performance and longevity of materials and devices at the micro/nanoscale.展开更多
Blepharoplasty is a frequently performed aesthetic surgery today aimed at enhancing eyelid appearance and correcting age-related changes.The traditional method of subtraction blepharoplasty,which involved removing fat...Blepharoplasty is a frequently performed aesthetic surgery today aimed at enhancing eyelid appearance and correcting age-related changes.The traditional method of subtraction blepharoplasty,which involved removing fat and excess skin,is now considered outdated.This letter explores Gorgy et al's commentary on Miotti et al's study,highlighting a shift in upper eyelid blepharoplasty towards a more conservative,volume-preserving approach.The study systematically reviewed 10 publications,including three retrospective studies,five comparative studies,and two clinical trials.It emphasizes the trend towards preserving the patient's natural anatomy and focusing on enhancement rather than alteration.However,the study's limitations,such as the lack of long-term comparative re-search,a relatively small sample size,and a single-center design,indicate that further research with extended follow-up is necessary to validate the safety and effectiveness of these techniques.The focus is increasingly on preserving and augmenting volume in upper blepharoplasty rather than removing tissue.展开更多
Scientists have suspected for a while that Greenland sharks live extremely long lives,but they didnt have a way to determine how long.The age of other shark species can be estimated by counting growth bands on fin spi...Scientists have suspected for a while that Greenland sharks live extremely long lives,but they didnt have a way to determine how long.The age of other shark species can be estimated by counting growth bands on fin spines(鳍脊)or on the sharksvertebrae(脊椎),much like rings of a tree.Greenland sharks,however,have no fin spines and no hard tissues in their bodies.Their vertebrae are too soft to form the growth bands seen in other sharks.Scientists could only guess that the sharks lived a long time based on what they knew—the sharks grow at a very slow rate and they can reach 6 meters in size.展开更多
The object of study selected for this paper is the Longevity Preface of the more controversially evaluated and less studied ancient writings of Qui Youguang.These essays are also the most included in the collection of...The object of study selected for this paper is the Longevity Preface of the more controversially evaluated and less studied ancient writings of Qui Youguang.These essays are also the most included in the collection of Qui Youguang’s writings,with differentiated content tendencies and a gradual convergence in the genre’s style.The artistic value embedded in the creation of Longevity Preface is rich in research value.The topic of this study is to analyze the innovations in the artistic characteristics of Longevity Preface by focusing on the specific breakthroughs in the image of the preface master,the expression of values,and the stylistic paradigm of Longevity Preface,so as to examine the contribution of Longevity Preface in the development of the genre.展开更多
Intermittent fasting(IF)has emerged as a potential adjunctive strategy in cancer prevention,mitigation,and treatment.This narrative review synthesizes existing literature to explore the relationship between IF and can...Intermittent fasting(IF)has emerged as a potential adjunctive strategy in cancer prevention,mitigation,and treatment.This narrative review synthesizes existing literature to explore the relationship between IF and cancer across 3 dimensions:prevention,mitigation,and treatment.We examine the underlying mechanisms by which IF may reduce cancer risk,including its effects on insulin-like growth factor 1 suppression,autophagy induction,and chronic inflammation reduction.Furthermore,we discuss IF’s potential to enhance the efficacy of conventional cancer therapies by sensitizing cancer cells,promoting apoptosis,and reducing treatmentrelated side effects.While promising,the evidence is still limited,and further research is required to elucidate the long-term impact and optimal implementation of IF in cancer care.This review aims to provide health care professionals and patients with a comprehensive understanding of the potential benefits and risks associated with IF as a complementary approach in the oncology setting.展开更多
The“longevity protein”SIRT5 could hold the key to delaying age-related muscle decline.A study led by researchers from the Institute of Zoology(IOZ)of the Chinese Academy of Sciences and Capital Medical University in...The“longevity protein”SIRT5 could hold the key to delaying age-related muscle decline.A study led by researchers from the Institute of Zoology(IOZ)of the Chinese Academy of Sciences and Capital Medical University in Beijing reveals that SIRT5 mitigates skeletal muscle aging by blocking pro-inflammatory pathways.Published in Nature Metabolism on March 14,2025,the work identifies SIRT5’s interaction with protein kinase TBK1 as critical to preserving muscle mass and function.展开更多
Guangxi Zhuang Autonomous Region is one of the most densely clustered regions of“Longevity County”in China,and Bama County is a typical representative of mountainous and hilly longevity villages in the country.In re...Guangxi Zhuang Autonomous Region is one of the most densely clustered regions of“Longevity County”in China,and Bama County is a typical representative of mountainous and hilly longevity villages in the country.In recent years,the local government and residents have actively embraced the United Nations Sustainable Development Goals(SDGs)and the Healthy China Initiative,striving to implement the scientific principle that“lucid waters and lush mountains are invaluable assets.”展开更多
This editorial commentary critically examines the systematic review by Miotti et al,which discusses the evolving trends in upper lid blepharoplasty towards a conservative,volume-preserving approach.The review emphasiz...This editorial commentary critically examines the systematic review by Miotti et al,which discusses the evolving trends in upper lid blepharoplasty towards a conservative,volume-preserving approach.The review emphasizes the shift from traditional tissue resection to techniques that maintain anatomical integrity,paralleling broader trends in panfacial rejuvenation.Miotti et al delve into the nuances of fat pad management,advocating for conservation over reduction to sustain natural contours and improve long-term aesthetic outcomes.This perspective is supported by comparative studies and empirical data,such as those from Massry and Alghoul et al,highlighting the benefits of conservative approaches in terms of patient satisfaction and aesthetic longevity.The review also stresses the importance of surgeon discretion in adapting procedures to diverse patient demographics,particularly in addressing distinct features such as the Asian upper eyelid.However,it identifies a significant gap in long-term comparative research,underscoring the need for future studies to substantiate the safety and efficacy of these minimalist techniques.Overall,Miotti et al.'s work contributes profoundly to the discourse on personalized,conservative cosmetic surgery,urging ongoing research to refine and validate surgical best practices in upper eyelid blepharoplasty.展开更多
Bats,notable as the only flying mammals,serve as natural reservoir hosts for various highly pathogenic viruses in humans(e.g.,SARS-CoV and Ebola virus).Furthermore,bats exhibit an unparalleled longevity among mammals ...Bats,notable as the only flying mammals,serve as natural reservoir hosts for various highly pathogenic viruses in humans(e.g.,SARS-CoV and Ebola virus).Furthermore,bats exhibit an unparalleled longevity among mammals relative to their size,particularly the Myotis bats,which can live up to 40 years.However,the mechanisms underlying these distinctive traits remain incompletely understood.In our prior research,we demonstrated that bats exhibit dampened STING-interferon activation,potentially conferring upon them the capacity to mitigate virus-or aging-induced inflammation.To substantiate this hypothesis,we established the first in vivo bat-mouse model for aging studies by integrating Myotis davidii bat STING(MdSTING)into the mouse genome.We monitored the genotypes of these mice and performed a longitudinal comparative transcriptomic analysis on MdSTING and wild-type mice over a 3-year aging process.Blood transcriptomic analysis indicated a reduction in aging-related inflammation in female MdSTING mice,as evidenced by significantly lower levels of pro-inflammatory cytokines and chemokines,immunopathology,and neutrophil recruitment in aged female MdSTING mice compared to aged wild-type mice in vivo.These results indicated that MdSTING knock-in attenuates the aging-related inflammatory response and may also improve the healthspan in mice in a sex-dependent manner.Although the underlying mechanism awaits further study,this research has critical implications for bat longevity research,potentially contributing to our comprehension of healthy aging in humans.展开更多
文摘We developed L3SN, a scalable, longevous, adaptive, and internet accessible wireless sensor network system for agriculture information monitoring, which is meticulously designed to meet the requirement of thousands hectares coverage, years of time monitoring and the adverse environment. The system architecture, the agriculture sensor device, the mesh protocol, and the web-based information processing platform are introduced. We also presented some implementation experience. The mesh protocol (LayerMesh) is highlighted, in which “stair scheduling” and “distributed dynamic load-balancing” are proposed to response the scalability, longevity and adaptivity requirements. We believe the design of L3SN is useful to many other large-scale, longevous applications such as hydrologic monitoring, geological monitoring etc.
基金the financial support from the Open Fund of Energy and Materials Chemistry Joint Laboratory of SCNU and TINCI,China(SCNU-TINCI-202207)supported by the Natural Science Foundation of China(No.52302283).
文摘Spinel LiMn_(2)O_(4)(LMO)is deemed to be a promising cathode material for commercial lithium-ion batteries(LIBs)in prospect of its cost-effectiveness,nontoxicity,fabulous rate capability,and high energy density.Nevertheless,the LMO is inevitably confronted with sluggish diffusion kinetics and drastic capacity degradation triggered by multiple issues,including Jahn-Teller distortion,Mn dissolution,and structural attenuation.Thereinto,a metal-organic framework(MOF)chemistry engineering for hierarchical micro-/nano-structural F,O-dual-doped carbon embedded oxygen vacancy enriched LiMn_(2)O_(4)cathode(OV-LMO@FOC)is proposed for longevous LIBs.Bestowed by experimental and theoretical implementations,systematic investigations of OV-LMO@FOC endow that the meticulous integration of F,O-dual-doped carbon and oxygen vacancy in LMO-based cathode reconfigures the electronic structure,boosts electronic conductivity,expedites diffusion capability,facilitates energetically preferable Li^(+) adsorption,and suppresses Mn dissolution in the electrolyte,consequently achieving fabulous long-term cycling stability.As expected,the OV-LMO@FOC behaves with compelling electrochemical performance with prosperous reversible capacity(130.2 mAh g^(−1)at 0.2 C upon 200 cycles),exceptional rate capacity(93.7 mAh g^(−1) even at 20 C),and pronounced long-term cyclability(112.5 mAh g^(−1)after 1200 cycles with 77.6%capacity retention at 1 C).Even at the ultrahigh current density of 5 C,the OV-LMO@FOC bears a brilliant capacity of 96.9 mAh g^(−1)upon 1000 cycles with an extraordinary capacity retention of 90.7%,and maintains a discharge capacity of 70.9 mAh g^(−1)upon 4000 cycles.This work envisions the MOF-chemistry in surface modification and electronic modulation engineering of high-performance cathode materials towards industrialization in automotive market.
基金funded by the National Key Research and Development Program of China (2023YFE0124400)the Specific university discipline construction project (2023B10564001)+1 种基金grants administered by the Arkansas Biosciences Institute and the USDAa core grant (P20GM121293, proteogenomics core)。
文摘Background Sow longevity and reproductivity are essential in the modern swine industry.Although many studies have focused on the genetic and genomic factors for selection,little is known about the associations between the microbiome and sows with longevity in reproduction.Results In this study,we collected and sequenced rectal and vaginal swabs from 48 sows,nine of which completed up to four parities(U4P group),exhibiting reproductive longevity.We first identified predictors of sow longevity in the rectum(e.g.,Akkermansia)and vagina(e.g.,Lactobacillus)of the U4P group using RandomForest in the early breeding stage of the first parity.Interestingly,these bacteria in the U4P group showed decreased predicted KEGG gene abundance involved in the biosynthesis of amino acids.Then,we tracked the longitudinal changes of the micro-biome over four parities in the U4P sows.LEfSe analysis revealed parity-associated bacteria that existed in both the rectum and vagina(e.g.,Streptococcus in Parity 1,Lactobacillus in Parity 2,Veillonella in Parity 4).We also identi-fied patterns of bacterial change between the early breeding stage(d 0)and d 110,such as Streptococcus,which was decreased in all four parties.Furthermore,sows in the U4P group with longevity potential also showed better reproductive performance.Finally,we discovered bacterial predictors(e.g.,Prevotellaceae NK3B31 group)for the total number of piglets born throughout the four parities in both the rectum and vagina.Conclusions This study highlights how the rectal and vaginal microbiome in sows with longevity in reproduc-tion changes within four parities.The identification of parity-associated,pregnancy-related,and reproductive performance-correlated bacteria provides the foundation for targeted microbiome modulation to improve animal production.
文摘Anti-aging research has become a popular scientific field with the increasing prominence of population aging.Rare ginsenoside Compound K(CK)has attracted widespread attention as an emerging anti-aging active ingredient.The anti-aging effect of ginsenosides is considered to be one of the important roles of ginsenosides,and Compound K,as the main deglycosylated metabolite of ginsenosides,has a comprehensive anti-aging effect as a highly active ingredient obtained by transformation under the action of microbiota.Recent studies have shown that ginsenosides have anti-photo-oxidation,anti-skin aging,free radical scavenging and immunostimulatory effects,which can effectively prevent skin photoaging.With the progress of modern natural medicine extraction technology and the deepening of the research on the anti-skin aging of ginsenosides'high active ingredients,it will promote the development and application of natural product protective skin photoaging preparations.The rare ginsenoside Compound K plays an important role in the improvement of skin health and anti-aging,which is mainly realized by increasing the activity of antioxidant enzymes,inducing the expression of related genes,reducing the content of oxidative damage substances,regulating the immune system,and influencing the expression of cell-cycle regulators and aging genes.A more comprehensive and in-depth study of the molecular mechanism of the anti-aging effect of rare ginsenoside Compound K will be one of the focuses of future research.
文摘Since ancient times,humanity has yearned for longevity,viewing health and long life as enduring aspirations.Research has shown that longevity genes may be passed down through certain populations(Costa D,2019).However,genetics alone is not the decisive factor-environmental conditions also play a vital role in achieving a long life(Selinus O,2013).
文摘Ten Thousand Years of Life.Chief Director:Zhou Xiaomeng.Length:12 Episodes.Producers:Hunan TV,Mango TV,and OBM.Broadcasting Platforms:Mango TV,and bilibili.In the backdrop of China’s aging society,this film series focuses on the community of elderly people in China who have enjoyed longevity.
文摘Secondary aging is characterized by nine cellular and molecular hallmarks including genomic instability,telomere attrition,epigenetic alterations,loss of proteostasis,deregulated nutrient sensing,mitochondrial dysfunction,cellular senescence,stem cell exhaustion,and altered intercellular communication.Exercise might be a uniquely valid intervention that can effectively promote healthy aging and attenuate age-related diseases without any side effects.On the molecular mechanism,exercise can effectively arrest all of the nine hallmarks of aging mentioned above.This review describes the mechanisms by which exercise can ameliorate these processes of aging.
基金support of the National Natural Science Foundation of China(U42107189,20A20111).
文摘Landslide dam failures can cause significant damage to both society and ecosystems.Predicting the failure of these dams in advance enables early preventive measures,thereby minimizing potential harm.This paper aims to propose a fast and accurate model for predicting the longevity of landslide dams while also addressing the issue of missing data.Given the wide variation in the survival times of landslide dams—from mere minutes to several thousand years—predicting their longevity presents a considerable challenge.The study develops predictive models by considering key factors such as dam geometry,hydrodynamic conditions,materials,and triggering parameters.A dataset of 1045 landslide dam cases is analyzed,categorizing their longevity into three distinct groups:C1(<1 month),C2(1 month to 1 year),and C3(>1 year).Multiple imputation and knearest neighbor algorithms are used to handle missing data on geometric size,hydrodynamic conditions,materials,and triggers.Based on the imputed data,two predictive models are developed:a classification model for dam longevity categories and a regression model for precise longevity predictions.The classification model achieves an accuracy of 88.38%while the regression model outperforms existing models with an R^(2) value of 0.966.Two real-life landslide dam cases are used to validate the models,which show correct classification and small prediction errors.The longevity of landslide dams is jointly influenced by factors such as geometric size,hydrodynamic conditions,materials,and triggering events.Among these,geometric size has the greatest impact,followed by hydrodynamic conditions,materials,and triggers,as confirmed by variable importance in the model development.
基金National Geographic Society,UCLA(Faculty Senate and the Division of Life Sciences),a Rocky Mountain Biological Laboratory research fellowship,NSF IDBR-0754247,and DEB-1119660 and 1557130 all to D.T.B.DBI-0242960,0731346,1226713,and 1755522 to the RMBL.K.A.was a NSF GRFP fellow during the fnal preparation of this MS。
文摘Emitting alarm calls may be costly,but few studies have asked whether calling increases a caller’s risk of predation and survival.Since observing animals calling and being killed is relatively rare,we capitalized on over 24,000 h of observations of marmot colonies and asked whether variation in the rate that yellow-bellied marmots(Marmota faviventer)alarm called was associated with the probability of summer mortality,a proxy for predation.Using a generalized mixed model that controlled for factors that infuenced the likelihood of survival,we found that marmots who called at higher rates were substantially more likely to die over the summer.Because virtually all summer mortality is due to predation,these results suggest that calling is indeed costly for marmots.Additionally,the results from a Cox survival analysis showed that marmots that called more lived signifcantly shorter lives.Prior studies have shown that marmots reduce the risk by emitting calls only when close to their burrows,but this newly quantifed survival cost suggests a constraint on eliminating risks.Quantifying the cost of alarm calling using a similar approach in other systems will help us better understand its true costs,which is an essential value for theoretical models of calling and social behavior.
文摘In Chinese tradition,the term“耄耋”(Mào Dié)refers to those in their nineties,a stage of life associated with wisdom and longevity.As the Bank of China Singapore Branch(BOCSG)approaches its 90th anniversary,this expression captures the spirit of an institution that has stood the test of time.Since its establishment in Singapore in 1936,the BOCSG has maintained a strong and enduring presence not only in Singapore but across Southeast Asia,serving as a bridge between China and Singapore,and more broadly,between China and the ASEAN region.Its continued growth has been underpinned by the mutual prosperity of both economies and the strength of their longstanding and harmonious ties.
文摘The lining materials for blast furnaces have evolved from brick masonry to monolithic refractory materials.Monolithic castables are widely used in various industrial furnaces.The rapid development of silica sol materials,combined with the commonly used construction methods of casting and spraying,offers greater flexibility,efficiency,environmental friendliness,and a longer lifespan.Typical monolithic refractory technologies,such as the integral casting technique for the furnace hearth,the pre-applied slag coating technique for the furnace belly and waist,and the inner lining gunning technique,are grounded in scientific theory and practice,thereby advancing the development of refractory materials and enhancing the operational quality of blast furnaces.
文摘Over the past three decades,micro/nano science and technology have experienced rapid advancements as new materials and advanced devices have increasingly evolved towards high levels of integration and miniaturization.In this context,mechanical properties have emerged as critical parameters for evaluating the operational performance and longevity of materials and devices at the micro/nanoscale.
文摘Blepharoplasty is a frequently performed aesthetic surgery today aimed at enhancing eyelid appearance and correcting age-related changes.The traditional method of subtraction blepharoplasty,which involved removing fat and excess skin,is now considered outdated.This letter explores Gorgy et al's commentary on Miotti et al's study,highlighting a shift in upper eyelid blepharoplasty towards a more conservative,volume-preserving approach.The study systematically reviewed 10 publications,including three retrospective studies,five comparative studies,and two clinical trials.It emphasizes the trend towards preserving the patient's natural anatomy and focusing on enhancement rather than alteration.However,the study's limitations,such as the lack of long-term comparative re-search,a relatively small sample size,and a single-center design,indicate that further research with extended follow-up is necessary to validate the safety and effectiveness of these techniques.The focus is increasingly on preserving and augmenting volume in upper blepharoplasty rather than removing tissue.
文摘Scientists have suspected for a while that Greenland sharks live extremely long lives,but they didnt have a way to determine how long.The age of other shark species can be estimated by counting growth bands on fin spines(鳍脊)or on the sharksvertebrae(脊椎),much like rings of a tree.Greenland sharks,however,have no fin spines and no hard tissues in their bodies.Their vertebrae are too soft to form the growth bands seen in other sharks.Scientists could only guess that the sharks lived a long time based on what they knew—the sharks grow at a very slow rate and they can reach 6 meters in size.
文摘The object of study selected for this paper is the Longevity Preface of the more controversially evaluated and less studied ancient writings of Qui Youguang.These essays are also the most included in the collection of Qui Youguang’s writings,with differentiated content tendencies and a gradual convergence in the genre’s style.The artistic value embedded in the creation of Longevity Preface is rich in research value.The topic of this study is to analyze the innovations in the artistic characteristics of Longevity Preface by focusing on the specific breakthroughs in the image of the preface master,the expression of values,and the stylistic paradigm of Longevity Preface,so as to examine the contribution of Longevity Preface in the development of the genre.
文摘Intermittent fasting(IF)has emerged as a potential adjunctive strategy in cancer prevention,mitigation,and treatment.This narrative review synthesizes existing literature to explore the relationship between IF and cancer across 3 dimensions:prevention,mitigation,and treatment.We examine the underlying mechanisms by which IF may reduce cancer risk,including its effects on insulin-like growth factor 1 suppression,autophagy induction,and chronic inflammation reduction.Furthermore,we discuss IF’s potential to enhance the efficacy of conventional cancer therapies by sensitizing cancer cells,promoting apoptosis,and reducing treatmentrelated side effects.While promising,the evidence is still limited,and further research is required to elucidate the long-term impact and optimal implementation of IF in cancer care.This review aims to provide health care professionals and patients with a comprehensive understanding of the potential benefits and risks associated with IF as a complementary approach in the oncology setting.
文摘The“longevity protein”SIRT5 could hold the key to delaying age-related muscle decline.A study led by researchers from the Institute of Zoology(IOZ)of the Chinese Academy of Sciences and Capital Medical University in Beijing reveals that SIRT5 mitigates skeletal muscle aging by blocking pro-inflammatory pathways.Published in Nature Metabolism on March 14,2025,the work identifies SIRT5’s interaction with protein kinase TBK1 as critical to preserving muscle mass and function.
文摘Guangxi Zhuang Autonomous Region is one of the most densely clustered regions of“Longevity County”in China,and Bama County is a typical representative of mountainous and hilly longevity villages in the country.In recent years,the local government and residents have actively embraced the United Nations Sustainable Development Goals(SDGs)and the Healthy China Initiative,striving to implement the scientific principle that“lucid waters and lush mountains are invaluable assets.”
文摘This editorial commentary critically examines the systematic review by Miotti et al,which discusses the evolving trends in upper lid blepharoplasty towards a conservative,volume-preserving approach.The review emphasizes the shift from traditional tissue resection to techniques that maintain anatomical integrity,paralleling broader trends in panfacial rejuvenation.Miotti et al delve into the nuances of fat pad management,advocating for conservation over reduction to sustain natural contours and improve long-term aesthetic outcomes.This perspective is supported by comparative studies and empirical data,such as those from Massry and Alghoul et al,highlighting the benefits of conservative approaches in terms of patient satisfaction and aesthetic longevity.The review also stresses the importance of surgeon discretion in adapting procedures to diverse patient demographics,particularly in addressing distinct features such as the Asian upper eyelid.However,it identifies a significant gap in long-term comparative research,underscoring the need for future studies to substantiate the safety and efficacy of these minimalist techniques.Overall,Miotti et al.'s work contributes profoundly to the discourse on personalized,conservative cosmetic surgery,urging ongoing research to refine and validate surgical best practices in upper eyelid blepharoplasty.
基金supported by the China Natural Science Foundation for Outstanding Scholars(82325032)Self-Supporting Program of Guangzhou Laboratory(SRPG22-001)。
文摘Bats,notable as the only flying mammals,serve as natural reservoir hosts for various highly pathogenic viruses in humans(e.g.,SARS-CoV and Ebola virus).Furthermore,bats exhibit an unparalleled longevity among mammals relative to their size,particularly the Myotis bats,which can live up to 40 years.However,the mechanisms underlying these distinctive traits remain incompletely understood.In our prior research,we demonstrated that bats exhibit dampened STING-interferon activation,potentially conferring upon them the capacity to mitigate virus-or aging-induced inflammation.To substantiate this hypothesis,we established the first in vivo bat-mouse model for aging studies by integrating Myotis davidii bat STING(MdSTING)into the mouse genome.We monitored the genotypes of these mice and performed a longitudinal comparative transcriptomic analysis on MdSTING and wild-type mice over a 3-year aging process.Blood transcriptomic analysis indicated a reduction in aging-related inflammation in female MdSTING mice,as evidenced by significantly lower levels of pro-inflammatory cytokines and chemokines,immunopathology,and neutrophil recruitment in aged female MdSTING mice compared to aged wild-type mice in vivo.These results indicated that MdSTING knock-in attenuates the aging-related inflammatory response and may also improve the healthspan in mice in a sex-dependent manner.Although the underlying mechanism awaits further study,this research has critical implications for bat longevity research,potentially contributing to our comprehension of healthy aging in humans.
