Background Sow longevity and reproductivity are essential in the modern swine industry.Although many studies have focused on the genetic and genomic factors for selection,little is known about the associations between...Background Sow longevity and reproductivity are essential in the modern swine industry.Although many studies have focused on the genetic and genomic factors for selection,little is known about the associations between the microbiome and sows with longevity in reproduction.Results In this study,we collected and sequenced rectal and vaginal swabs from 48 sows,nine of which completed up to four parities(U4P group),exhibiting reproductive longevity.We first identified predictors of sow longevity in the rectum(e.g.,Akkermansia)and vagina(e.g.,Lactobacillus)of the U4P group using RandomForest in the early breeding stage of the first parity.Interestingly,these bacteria in the U4P group showed decreased predicted KEGG gene abundance involved in the biosynthesis of amino acids.Then,we tracked the longitudinal changes of the micro-biome over four parities in the U4P sows.LEfSe analysis revealed parity-associated bacteria that existed in both the rectum and vagina(e.g.,Streptococcus in Parity 1,Lactobacillus in Parity 2,Veillonella in Parity 4).We also identi-fied patterns of bacterial change between the early breeding stage(d 0)and d 110,such as Streptococcus,which was decreased in all four parties.Furthermore,sows in the U4P group with longevity potential also showed better reproductive performance.Finally,we discovered bacterial predictors(e.g.,Prevotellaceae NK3B31 group)for the total number of piglets born throughout the four parities in both the rectum and vagina.Conclusions This study highlights how the rectal and vaginal microbiome in sows with longevity in reproduc-tion changes within four parities.The identification of parity-associated,pregnancy-related,and reproductive performance-correlated bacteria provides the foundation for targeted microbiome modulation to improve animal production.展开更多
Since ancient times,humanity has yearned for longevity,viewing health and long life as enduring aspirations.Research has shown that longevity genes may be passed down through certain populations(Costa D,2019).However,...Since ancient times,humanity has yearned for longevity,viewing health and long life as enduring aspirations.Research has shown that longevity genes may be passed down through certain populations(Costa D,2019).However,genetics alone is not the decisive factor-environmental conditions also play a vital role in achieving a long life(Selinus O,2013).展开更多
Landslide dam failures can cause significant damage to both society and ecosystems.Predicting the failure of these dams in advance enables early preventive measures,thereby minimizing potential harm.This paper aims to...Landslide dam failures can cause significant damage to both society and ecosystems.Predicting the failure of these dams in advance enables early preventive measures,thereby minimizing potential harm.This paper aims to propose a fast and accurate model for predicting the longevity of landslide dams while also addressing the issue of missing data.Given the wide variation in the survival times of landslide dams—from mere minutes to several thousand years—predicting their longevity presents a considerable challenge.The study develops predictive models by considering key factors such as dam geometry,hydrodynamic conditions,materials,and triggering parameters.A dataset of 1045 landslide dam cases is analyzed,categorizing their longevity into three distinct groups:C1(<1 month),C2(1 month to 1 year),and C3(>1 year).Multiple imputation and knearest neighbor algorithms are used to handle missing data on geometric size,hydrodynamic conditions,materials,and triggers.Based on the imputed data,two predictive models are developed:a classification model for dam longevity categories and a regression model for precise longevity predictions.The classification model achieves an accuracy of 88.38%while the regression model outperforms existing models with an R^(2) value of 0.966.Two real-life landslide dam cases are used to validate the models,which show correct classification and small prediction errors.The longevity of landslide dams is jointly influenced by factors such as geometric size,hydrodynamic conditions,materials,and triggering events.Among these,geometric size has the greatest impact,followed by hydrodynamic conditions,materials,and triggers,as confirmed by variable importance in the model development.展开更多
Guangxi Zhuang Autonomous Region is one of the most densely clustered regions of“Longevity County”in China,and Bama County is a typical representative of mountainous and hilly longevity villages in the country.In re...Guangxi Zhuang Autonomous Region is one of the most densely clustered regions of“Longevity County”in China,and Bama County is a typical representative of mountainous and hilly longevity villages in the country.In recent years,the local government and residents have actively embraced the United Nations Sustainable Development Goals(SDGs)and the Healthy China Initiative,striving to implement the scientific principle that“lucid waters and lush mountains are invaluable assets.”展开更多
The object of study selected for this paper is the Longevity Preface of the more controversially evaluated and less studied ancient writings of Qui Youguang.These essays are also the most included in the collection of...The object of study selected for this paper is the Longevity Preface of the more controversially evaluated and less studied ancient writings of Qui Youguang.These essays are also the most included in the collection of Qui Youguang’s writings,with differentiated content tendencies and a gradual convergence in the genre’s style.The artistic value embedded in the creation of Longevity Preface is rich in research value.The topic of this study is to analyze the innovations in the artistic characteristics of Longevity Preface by focusing on the specific breakthroughs in the image of the preface master,the expression of values,and the stylistic paradigm of Longevity Preface,so as to examine the contribution of Longevity Preface in the development of the genre.展开更多
With the ongoing advancement of human civilization,China is increasingly prioritizing the preservation and transmission of its architectural heritage.This study examines the historical development of the Longevity Pag...With the ongoing advancement of human civilization,China is increasingly prioritizing the preservation and transmission of its architectural heritage.This study examines the historical development of the Longevity Pagoda in Jingzhou,synthesizing its architectural and artistic characteristics as well as its cultural heritage value.In light of contemporary challenges,the paper proposes strategies for the protection and preservation of the Longevity Pagoda.The aim is to ensure that the Longevity Pagoda continues to realize its distinctive historical,cultural,and social significance in the future.展开更多
In this paper,we propose a simple dynamic mortality model to fit and forecast mortality rates for measuring longevity and mortality risks.This proposal is based on a methodology for modelling interest rates,which assu...In this paper,we propose a simple dynamic mortality model to fit and forecast mortality rates for measuring longevity and mortality risks.This proposal is based on a methodology for modelling interest rates,which assumes that changes in spot interest rates depend linearly on a small number of factors.These factors are identified as interest rates with a given maturity.Similarly,we assume that changes in mortality rates depend linearly on changes in a specific mortality rate,which we call the key mortality rate.One of the main advantages of this model is that it allows the development of an easy to implement methodology to measure longevity and mortality risks using simulation techniques.Particularly,we employ the model to calculate the Value-at-Risk and Conditional-Value-at-Risk of an insurance product testing the accuracy and robustness of our proposal using out-of-sample data from six different populations.展开更多
Anti-aging research has become a popular scientific field with the increasing prominence of population aging.Rare ginsenoside Compound K(CK)has attracted widespread attention as an emerging anti-aging active ingredien...Anti-aging research has become a popular scientific field with the increasing prominence of population aging.Rare ginsenoside Compound K(CK)has attracted widespread attention as an emerging anti-aging active ingredient.The anti-aging effect of ginsenosides is considered to be one of the important roles of ginsenosides,and Compound K,as the main deglycosylated metabolite of ginsenosides,has a comprehensive anti-aging effect as a highly active ingredient obtained by transformation under the action of microbiota.Recent studies have shown that ginsenosides have anti-photo-oxidation,anti-skin aging,free radical scavenging and immunostimulatory effects,which can effectively prevent skin photoaging.With the progress of modern natural medicine extraction technology and the deepening of the research on the anti-skin aging of ginsenosides'high active ingredients,it will promote the development and application of natural product protective skin photoaging preparations.The rare ginsenoside Compound K plays an important role in the improvement of skin health and anti-aging,which is mainly realized by increasing the activity of antioxidant enzymes,inducing the expression of related genes,reducing the content of oxidative damage substances,regulating the immune system,and influencing the expression of cell-cycle regulators and aging genes.A more comprehensive and in-depth study of the molecular mechanism of the anti-aging effect of rare ginsenoside Compound K will be one of the focuses of future research.展开更多
基金funded by the National Key Research and Development Program of China (2023YFE0124400)the Specific university discipline construction project (2023B10564001)+1 种基金grants administered by the Arkansas Biosciences Institute and the USDAa core grant (P20GM121293, proteogenomics core)。
文摘Background Sow longevity and reproductivity are essential in the modern swine industry.Although many studies have focused on the genetic and genomic factors for selection,little is known about the associations between the microbiome and sows with longevity in reproduction.Results In this study,we collected and sequenced rectal and vaginal swabs from 48 sows,nine of which completed up to four parities(U4P group),exhibiting reproductive longevity.We first identified predictors of sow longevity in the rectum(e.g.,Akkermansia)and vagina(e.g.,Lactobacillus)of the U4P group using RandomForest in the early breeding stage of the first parity.Interestingly,these bacteria in the U4P group showed decreased predicted KEGG gene abundance involved in the biosynthesis of amino acids.Then,we tracked the longitudinal changes of the micro-biome over four parities in the U4P sows.LEfSe analysis revealed parity-associated bacteria that existed in both the rectum and vagina(e.g.,Streptococcus in Parity 1,Lactobacillus in Parity 2,Veillonella in Parity 4).We also identi-fied patterns of bacterial change between the early breeding stage(d 0)and d 110,such as Streptococcus,which was decreased in all four parties.Furthermore,sows in the U4P group with longevity potential also showed better reproductive performance.Finally,we discovered bacterial predictors(e.g.,Prevotellaceae NK3B31 group)for the total number of piglets born throughout the four parities in both the rectum and vagina.Conclusions This study highlights how the rectal and vaginal microbiome in sows with longevity in reproduc-tion changes within four parities.The identification of parity-associated,pregnancy-related,and reproductive performance-correlated bacteria provides the foundation for targeted microbiome modulation to improve animal production.
文摘Since ancient times,humanity has yearned for longevity,viewing health and long life as enduring aspirations.Research has shown that longevity genes may be passed down through certain populations(Costa D,2019).However,genetics alone is not the decisive factor-environmental conditions also play a vital role in achieving a long life(Selinus O,2013).
基金support of the National Natural Science Foundation of China(U42107189,20A20111).
文摘Landslide dam failures can cause significant damage to both society and ecosystems.Predicting the failure of these dams in advance enables early preventive measures,thereby minimizing potential harm.This paper aims to propose a fast and accurate model for predicting the longevity of landslide dams while also addressing the issue of missing data.Given the wide variation in the survival times of landslide dams—from mere minutes to several thousand years—predicting their longevity presents a considerable challenge.The study develops predictive models by considering key factors such as dam geometry,hydrodynamic conditions,materials,and triggering parameters.A dataset of 1045 landslide dam cases is analyzed,categorizing their longevity into three distinct groups:C1(<1 month),C2(1 month to 1 year),and C3(>1 year).Multiple imputation and knearest neighbor algorithms are used to handle missing data on geometric size,hydrodynamic conditions,materials,and triggers.Based on the imputed data,two predictive models are developed:a classification model for dam longevity categories and a regression model for precise longevity predictions.The classification model achieves an accuracy of 88.38%while the regression model outperforms existing models with an R^(2) value of 0.966.Two real-life landslide dam cases are used to validate the models,which show correct classification and small prediction errors.The longevity of landslide dams is jointly influenced by factors such as geometric size,hydrodynamic conditions,materials,and triggering events.Among these,geometric size has the greatest impact,followed by hydrodynamic conditions,materials,and triggers,as confirmed by variable importance in the model development.
文摘Guangxi Zhuang Autonomous Region is one of the most densely clustered regions of“Longevity County”in China,and Bama County is a typical representative of mountainous and hilly longevity villages in the country.In recent years,the local government and residents have actively embraced the United Nations Sustainable Development Goals(SDGs)and the Healthy China Initiative,striving to implement the scientific principle that“lucid waters and lush mountains are invaluable assets.”
文摘The object of study selected for this paper is the Longevity Preface of the more controversially evaluated and less studied ancient writings of Qui Youguang.These essays are also the most included in the collection of Qui Youguang’s writings,with differentiated content tendencies and a gradual convergence in the genre’s style.The artistic value embedded in the creation of Longevity Preface is rich in research value.The topic of this study is to analyze the innovations in the artistic characteristics of Longevity Preface by focusing on the specific breakthroughs in the image of the preface master,the expression of values,and the stylistic paradigm of Longevity Preface,so as to examine the contribution of Longevity Preface in the development of the genre.
文摘With the ongoing advancement of human civilization,China is increasingly prioritizing the preservation and transmission of its architectural heritage.This study examines the historical development of the Longevity Pagoda in Jingzhou,synthesizing its architectural and artistic characteristics as well as its cultural heritage value.In light of contemporary challenges,the paper proposes strategies for the protection and preservation of the Longevity Pagoda.The aim is to ensure that the Longevity Pagoda continues to realize its distinctive historical,cultural,and social significance in the future.
文摘In this paper,we propose a simple dynamic mortality model to fit and forecast mortality rates for measuring longevity and mortality risks.This proposal is based on a methodology for modelling interest rates,which assumes that changes in spot interest rates depend linearly on a small number of factors.These factors are identified as interest rates with a given maturity.Similarly,we assume that changes in mortality rates depend linearly on changes in a specific mortality rate,which we call the key mortality rate.One of the main advantages of this model is that it allows the development of an easy to implement methodology to measure longevity and mortality risks using simulation techniques.Particularly,we employ the model to calculate the Value-at-Risk and Conditional-Value-at-Risk of an insurance product testing the accuracy and robustness of our proposal using out-of-sample data from six different populations.
文摘Anti-aging research has become a popular scientific field with the increasing prominence of population aging.Rare ginsenoside Compound K(CK)has attracted widespread attention as an emerging anti-aging active ingredient.The anti-aging effect of ginsenosides is considered to be one of the important roles of ginsenosides,and Compound K,as the main deglycosylated metabolite of ginsenosides,has a comprehensive anti-aging effect as a highly active ingredient obtained by transformation under the action of microbiota.Recent studies have shown that ginsenosides have anti-photo-oxidation,anti-skin aging,free radical scavenging and immunostimulatory effects,which can effectively prevent skin photoaging.With the progress of modern natural medicine extraction technology and the deepening of the research on the anti-skin aging of ginsenosides'high active ingredients,it will promote the development and application of natural product protective skin photoaging preparations.The rare ginsenoside Compound K plays an important role in the improvement of skin health and anti-aging,which is mainly realized by increasing the activity of antioxidant enzymes,inducing the expression of related genes,reducing the content of oxidative damage substances,regulating the immune system,and influencing the expression of cell-cycle regulators and aging genes.A more comprehensive and in-depth study of the molecular mechanism of the anti-aging effect of rare ginsenoside Compound K will be one of the focuses of future research.
