Since ancient times,humanity has yearned for longevity,viewing health and long life as enduring aspirations.Research has shown that longevity genes may be passed down through certain populations(Costa D,2019).However,...Since ancient times,humanity has yearned for longevity,viewing health and long life as enduring aspirations.Research has shown that longevity genes may be passed down through certain populations(Costa D,2019).However,genetics alone is not the decisive factor-environmental conditions also play a vital role in achieving a long life(Selinus O,2013).展开更多
Butterflies are diverse in virtually all aspects of their ontogeny,including morphology,life history,and behavior.However,the developmental regulatory mechanisms underlying the important phenotypic traits of butterfli...Butterflies are diverse in virtually all aspects of their ontogeny,including morphology,life history,and behavior.However,the developmental regulatory mechanisms underlying the important phenotypic traits of butterflies at different developmental stages remain unknown.Here,we investigated the developmental regulatory profiles of butterflies based on transposase accessible chromatin sequencing(ATAC-seq)at three developmental stages in two representative species(Papilio xuthus and Kallima inachus).展开更多
GaN-based continuous-wave operated blue-violet laser diodes(LDs) with long lifetime are demonstrated, which are grown on a c-plane GaN substrate by metal organic chemical vapor deposition with a 10 × 600 μm^2 ri...GaN-based continuous-wave operated blue-violet laser diodes(LDs) with long lifetime are demonstrated, which are grown on a c-plane GaN substrate by metal organic chemical vapor deposition with a 10 × 600 μm^2 ridge waveguide structure.The electrical and optical characteristics of a blue-violet LD are investigated under direct-current injection at room temperature(25 °C). The stimulated emission wavelength and peak optical power of the LD are around 413 nm and over 600 mW, respectively.In addition, the threshold current density and voltage are as small as 1.46 kA/cm^2 and 4.1 V, respectively. Moreover, the lifetime is longer than 1000 hours under room-temperature continuous-wave operation.展开更多
Prolongation of the QT interval is associated with adverse cardiac events specifically Torsades de pointes(TdP).There are multiple mediations that have a known,possible,or conditional risk for prolonged QT interval,bu...Prolongation of the QT interval is associated with adverse cardiac events specifically Torsades de pointes(TdP).There are multiple mediations that have a known,possible,or conditional risk for prolonged QT interval,but general practitioners’knowledge of these medications is unknown.We conducted a survey to assess internal medicine(IM)providers’knowledge of risk factors and medications associated with prolonged QT as well as provider experience and comfort when treating patients with prolonged QT.A 17-question,anonymous survey was constructed in 2019 and distributed to IM providers and residents at a tertiary care center.Questions included demographic information,6 Likert-scale questions gauging provider experience with prolonged QT,and 10 multiple choice clinical vignettes to assess clinical knowledge.Data was analyzed descriptively.Knowledge was assessed via clinical vignettes and compared by level of training.Forty-one responses were received out of a total of 87 possible respondents(47.1%response rate).About 70%of respondents see patients with acquired prolonged QT once monthly or more.95%rarely see congenital prolonged QT.When presented with QTc drug issues,73%of providers seldom or sometimes consulted pharmacy,but about half used online resources.The average correct score on the clinical vignettes was 5.59/10,with the highest scores seen in attending physicians in their first five years of practice(6.96/10).Our survey suggests that IM providers commonly encounter QT prolonging drugs.Educational efforts to improve knowledge of drug and patient risk factors for TdP may be needed.展开更多
Baosteel No. 3 BF has been running smoothly and stably for more than 18 years and has become China＇ s longest-life blast furnace, producing many advanced economical and technical indexes. Comprehensive longevity tech...Baosteel No. 3 BF has been running smoothly and stably for more than 18 years and has become China＇ s longest-life blast furnace, producing many advanced economical and technical indexes. Comprehensive longevity technology has been developed in terms of the design, operation, and maintenance of the No. 3 BF during the prolonged period of research and practice. To obtain stable and smooth operation and to prolong the campaign life, the following measures have been taken： appropriate designing of the furnace profile and cooling system; improving raw material quality and optimizing the operating system; improving the cooling intensity and water quality;and adopting various longevity maintenance measures to ensure the safety of the body and the hearth temperature.展开更多
BACKGROUND The Coronavirus Disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 virus is an international health concern with substantial morbidity and mortality.COVID-associated cystiti...BACKGROUND The Coronavirus Disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 virus is an international health concern with substantial morbidity and mortality.COVID-associated cystitis(CAC),presents as new onset or exacerbated urinary symptoms,resembling overactive bladder(OAB)symptoms.AIM To examines the long-term outcomes of patients with CAC in the context of Long COVID.METHODS A cohort of 350 patients admitted to Detroit Hospitals with COVID-19 between May and December 2020,displaying CAC symptoms following discharge,was prospectively followed.Initial urologic evaluations occurred at 10-14 wk and were repeated at 21-28 mo postdischarge.Symptoms were managed conservatively,employing behavioral modifications and standard OAB medications.Participants completed surveys assessing urinary symptoms and quality of life(QoL)at both time points.The primary outcome was the Urology Care Foundation Overactive Bladder Assessment Tool.RESULTS 87%of the final cohort(n=310)reported symptom improvement at 21-28 mo post-discharge.Patients with new onset CAC symptoms showed a median decrease of 9-10 points in OAB and QoL scores,while those with existing symptoms experienced a decrease of 6 points.Overall,95.4%of patients with new onset symptoms reported symptom improvement at follow-up,contrasting with 60.7%among those with existing symptoms.CONCLUSION This study presents the first long-term follow-up of adult patients with CAC,revealing a promising prognosis with conservative management measures in the context of Long COVID.These findings provide reassurance to patients regarding symptom resolution and underscore the need for further research into this evolving aspect of COVID-19's impact on urological health.展开更多
Aim:?To explore the longer term blood glucose self-monitoring outcomes and frequency of monitoring for outpatients with diabetes type 1 after completion of the Dose Adjustment for Normal Eating (DAFNE) course. The hyp...Aim:?To explore the longer term blood glucose self-monitoring outcomes and frequency of monitoring for outpatients with diabetes type 1 after completion of the Dose Adjustment for Normal Eating (DAFNE) course. The hypothesis was that DAFNE outcomes would differ according to frequency of glucose monitoring.Methods:?A?sequential data-triangulation design using existing?baseline (T0) and 12-months (T12)?DAFNE course data and interview data from 12 randomly selected participants who had completed the course two years ago.?Results: Age range was 23 to 70 years with HbA1c 6.1% to 12.6% at T0?and 6.1% to 11.4% at T12. Comparisons of HbA1c, PAID, HAD subscales?anxiety?and?depression,?and covariate data between T0?and T12indicatedsignificant reductions in the mean depression and PAID scores (both?P?< 0.001) for the whole group. For the two groups who recorded their blood glucose less than three times or three or more times per day, changes were not significantly different. For both groups, the trend between T0?and T12?was downwards for change in mean blood glucose level and all survey scales. The proportion of all participants with T12?HbA1c at or below their T0?value was greater than 50% (Proportion = 69%, 95% CI: 56% - 79%) but only the highest HbA1c tertile group showed a significant difference (P?= 0.003). There was an average decrease in the incidence of hypoglycaemic events of 0.6 overall: The greatest change was for the high HbA1c tertile with a mean decrease of 0.8. The interview data suggested that DAFNE graduates experimented more with food, exercise, and insulin;gained knowledge;learnt personal body needs;increased awareness of blood glucose level;gained confidence and improved their quality of life. Conclusions: There was insufficient evidence to conclude that frequency of blood glucose monitoring influenced metabolic control. However, people with type 1 diabetes who undertake the less restricted DAFNE approach to diabetes self-management can improve their quality of life and glycaemic control.展开更多
The exploration of human life and health is advancing with the changes of the times.With the growth of age,the occurrence of chronic diseases of human immunity and organ system is frequent,which has a serious impact o...The exploration of human life and health is advancing with the changes of the times.With the growth of age,the occurrence of chronic diseases of human immunity and organ system is frequent,which has a serious impact on human health.Genes,environment and other random factors determine the outcome of longevity,and intestinal flora is considered to be a decisive factor affecting human health and longevity,mainly because of its huge impact on human immunity,growth and development.The study of the relationship between intestinal flora and longevity is beneficial to improve the health status of the elderly and improve the overall life level of human beings,which has great scientific research value.This review will review the role of intestinal flora in longevity.展开更多
During long-term evolution,plants have signified a shift in their life-history strategy from perenniality to annuality to rapidly complete their reproduction in variable climatic environments.However,as the human popu...During long-term evolution,plants have signified a shift in their life-history strategy from perenniality to annuality to rapidly complete their reproduction in variable climatic environments.However,as the human population is rapidly increasing and fossil fuels are being increasingly consumed,it becomes essential to develop low-carbon agriculture and sustainable industries.Therefore,it is important to improve plant perennial flowering behavior to upgrade biomass production and maintain biodiversity as a green revolution and carbon neutralization strategy[1].展开更多
Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathologica...Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.展开更多
Herein,manganese(Mn)‑doped poly(1,5‑diaminonaphthalene)(PN)electrode material(Mn@PN)was synthesized via chemical oxidative polymerization.The material′s distinctive vesicular architecture enables rapid ion transport ...Herein,manganese(Mn)‑doped poly(1,5‑diaminonaphthalene)(PN)electrode material(Mn@PN)was synthesized via chemical oxidative polymerization.The material′s distinctive vesicular architecture enables rapid ion transport while maintaining the structural stability of the electrode under continuous charge‑discharge cycles.Electrochemical characterization under a three‑electrode system revealed exceptional rate capability:Mn@PN delivered an ultrahigh specific capacitance of 10318 F·g^(-1) at a low current density of 3 A·g^(-1) and retained 9415 F·g^(-1)(91.2%retention compared to the value at 3 A·g^(-1))even at an ultrahigh current density of 50 A·g^(-1).Moreover,the material exhibited 97.4%capacitance retention after 9000 cycles at 30 A·g^(-1),corresponding with a low capacitance decay rate of 0.003‰per cycle,significantly outperforming conventional conductive polymers like polyaniline(PANI).An asymmetric supercapacitor assembled with Mn@PN as the positive electrode(Mn@PN||AC)achieved an energy density of 328 Wh·kg^(-1) at 15 A·g^(-1) and retained 80.7%of its initial specific capacitance after 4000 cycles at 20 A·g^(-1).展开更多
Genomic destabilization and defective DNA repair are the most prominent features of tumour cells and are exploited by various chemotherapy drugs for cancer therapy.Long non-coding RNA(lncR-NAs)have emerged as powerful...Genomic destabilization and defective DNA repair are the most prominent features of tumour cells and are exploited by various chemotherapy drugs for cancer therapy.Long non-coding RNA(lncR-NAs)have emerged as powerful regulators of gene expression and are thus involved in diverse biological processes.Recent studies have demonstrated that several lncRNAs play critical roles in DNA repair.Nonetheless,the relationship between DNA damage-responsive lncRNAs and chemoresistance remains poorly defined.In this study,we established four different DNA damage models triggered by cisplatin(DDP),H2O2,neocarzinostatin(NCS)or ultraviolet(UV)irradiation and identified a specific upregu-lated lncRNA(lnc-DUSP6)involved in the cisplatin-induced DNA damage response.Furthermore,loss-or gain-of-function experiments confirmed that lnc-DUSP6 enhanced DNA repair and cell survival under cisplatin treatment,thus promoting cisplatin resistance.Mechanistically,an RNA immunoprecipitation(RIP)assay revealed that lnc-DUSP6 directly interacts with DUSP6(Dual Specificity Phosphatase 6),which is closely associated with cisplatin sensitivity.Additionally,overexpression of DUSP6 significantly rescued the effects of lnc-DUSP6 silencing on DNA repair and cell survival under cisplatin treatment.O-verall,our results show the effect and underlying mechanism of lnc-DUSP6 in cisplatin resistance:lnc-DUSP6 promotes cisplatin-induced DNA damage repair and cisplatin resistance by stabilizing DUSP6,which is highly clinically important for enhancing the efficacy of cisplatin for cancers.展开更多
In a recent paper published in a special issue of Integrative Zoology on‘Paleontology and evolution–part I.’(Palombo 2014),the author(van der Geer 2014)takes a review of the derived traits observed in endemic fossi...In a recent paper published in a special issue of Integrative Zoology on‘Paleontology and evolution–part I.’(Palombo 2014),the author(van der Geer 2014)takes a review of the derived traits observed in endemic fossil insular mammals,including body size variation,cranial and postcranial changes,and modifications in dentition.At one point in the discussion,the author misinterprets and seriously distorts statements by Jordana et al.(2012)on the relationship between hypsodonty and longevity in the fossil insular bovid Myotragus balearicus Bate,1909.展开更多
Introduction The pursuit of optimal health and longevity is a long-standing human aspiration[1,2].Advances in public health policies and population medicine have significantly extended life expectancy,which has triple...Introduction The pursuit of optimal health and longevity is a long-standing human aspiration[1,2].Advances in public health policies and population medicine have significantly extended life expectancy,which has tripled from 20–30 years a century and a half ago.However,this has also led to an increase in age-related diseases.As we age,stem cells,the foundation of every organ and tissue in our body,lose their regenerative capacity,leading to tissue decline and age-related diseases.Environmental conditions and disease treatments can also negatively impact the quality of life and health span[3].展开更多
Long-afterglow photocatalytic technology offers promising potential fo r all-weather pollutant treatment,yet its efficiency is often constrained by competition between afterglow emission and photocatalytic reactions.T...Long-afterglow photocatalytic technology offers promising potential fo r all-weather pollutant treatment,yet its efficiency is often constrained by competition between afterglow emission and photocatalytic reactions.To address this,we developed a Pr^(3+)-doped Ca_(2)Al_(2)SiO_(7)(CASO)photocatalyst enriched with oxygen vacancies(V_(O)).The introduction of oxygen vacancies significantly increases trap concentration,enhancing both the intensity and du ration of the afterglow emission.A persulfate-assisted photo-Fenton system was designed based on V_(O)-CASO:Pr^(3+)enabling the self-activated degradation of tetracycline hydrochloride(TC)under ultraviolet afterglow.The photo-Fenton reaction consumes excess holes accumulated during the afterglow process,improving carrier utilization efficiency and mitigating rapid recombination.Additionally,persulfate addition can enrich reactive species and facilitate the Fe^(2+)/Fe^(3+)cycle.Benefiting from these synergistic effects,V_(O)-CASO:Pr^(3+)has achieved 75%TC degradation within1 h,significantly outperforming traditional systems.This study provides a new strategy for enhancing long-afterglow photocatalytic performance,paving the way for sustainable pollutant degradation technologies.展开更多
Long COVID is characterized by a group of persistent symptoms following the acute SARS-COV2 infection, which presented a multifaceted challenge to the healthcare systems all over the globe. The long COVID symptoms spa...Long COVID is characterized by a group of persistent symptoms following the acute SARS-COV2 infection, which presented a multifaceted challenge to the healthcare systems all over the globe. The long COVID symptoms span various organ systems including the respiratory, cardiovascular, gastrointestinal, and neurological manifestations. Mitochondrial dysfunction and immune dysregulation play crucial roles in the long COVID pathophysiology. Recently nutritional intervention gained much attention in managing post-viral syndromes. Effective interventions like supplementation of omega-3 fatty acid, macro and micro nutrients, and vitamins help to reduce systemic inflammation and counteract muscle wasting. Other approaches like nutritional recovery, dietetic interventions, continuous nutritional care post-hospital discharge, nutritional rehabilitation programs,whole-diet approaches like Mediterranean diet, plant-based diet, and caloric optimization, improve overall functional recovery. Physical activity and exercise regimes have been shown to improve fatigue, dyspnea, and cognitive function. Tailored exercise regimes may promote safe rehabilitation. Certain ineffective interventions,such as non-personalized approaches, high dose of antioxidants, use of herbal products that are not clinically validated need to be addressed. Dietary interventions such as personalized nutritional counseling have been demonstrated to improve physical performance in long COVID patients. Further research is needed to refine protocols and identify optimal combinations of dietary and movement-based therapies to support the recovery of long-COVID patients. This narrative review focuses on the ongoing researches that reveals the intricate relationship between nutrition and long COVID recovery and also establishes effective protocols for nutritional care.展开更多
Objective:The contribution of long non-coding RNAs(lncRNAs)associated with protein palmitoylation to the progression of hepatocellular carcinoma(HCC)remains largely unclear.This study sought to establish a prognostic ...Objective:The contribution of long non-coding RNAs(lncRNAs)associated with protein palmitoylation to the progression of hepatocellular carcinoma(HCC)remains largely unclear.This study sought to establish a prognostic signature based on palmitoylation-related lncRNAs and explore their functional implications in HCC.Methods:RNA sequencing and clinical data for HCC and normal tissues were sourced from the Cancer Genome Atlas(TCGA).Pearson correlation analysis was used to identify lncRNAs that were co-expressed with palmitoylation-related genes.Univariate Cox regression was applied to select lncRNAs with prognostic value,followed by the construction of a predictive model using the least absolute shrinkage and selection operator(LASSO)regression.A focused analysis was performed on one key lncRNA,AC009403.1.Expression levels of the final nine lncRNAs included in the model were further validated by reverse transcription quantitative polymerase chain reaction(RT-qPCR).Results:A prognostic model for HCC was developed using nine palmitoylation-associated lncRNAs:AC009403.1,AC010789.1,AC026402.2,AC107021.2,AC135050.6,AL353572.4,MKLN1-AS,PRRT3-AS1,and ZNF582-AS1.This model effectively stratified patients into high-and low-risk groups exhibiting significantly different overall survival(OS)and progression-free survival(PFS),with the low-risk group showing more favorable outcomes.The high-risk group was associated with an immunosuppressive microenvironment,higher tumor mutation burden(TMB),and increased sensitivity to certain chemotherapeutic drugs(e.g.,Sorafenib).Finally,RT-qPCR validation revealed that all nine lncRNAs were significantly upregulated in HCC tissues.Conclusion:The nine-lncRNA signature exhibits robust predictive power for HCC prognosis and provides novel insights into the mechanisms of lncRNA-regulated palmitoylation in HCC development.展开更多
Structural variations(SVs≥50 bp)are a critical but underexplored source of genetic diversity in cattle,shaping traits vital for productivity,adaptability,and health.Advances in long-read sequencing,pangenome graph co...Structural variations(SVs≥50 bp)are a critical but underexplored source of genetic diversity in cattle,shaping traits vital for productivity,adaptability,and health.Advances in long-read sequencing,pangenome graph construction,and near-complete genome assemblies now allow accurate SV detection and genotyping.These innovations overcome the limitations of single-reference genomes,enabling the discovery of complex SVs,including nested and overlapping variants,and providing access to previously inaccessible genomic regions such as centromeres and telomeres.This review highlights the current landscape of cattle SV research,with emphasis on integrating longread sequencing and pangenome frameworks to uncover breed-specific and population-level variation.While many SVs are linked to economically important traits such as feed efficiency and disease resistance,their broader regulatory impacts remain an active area of investigation.Emerging functional genomics approaches,including transcriptomics,epigenomics,and genome editing,will clarify how SVs influence gene regulation and phenotype.Looking forward,the integration of SV catalogs with multi-omics data,imputation resources,and artificial intelligence-driven models will be essential for translating discoveries into breeding and conservation applications.Integrating structural variants into breeding pipelines promises to revolutionize livestock genomics,enabling precision selection and sustainable agriculture despite challenges in cost,data sharing,and functional validation.展开更多
文摘Since ancient times,humanity has yearned for longevity,viewing health and long life as enduring aspirations.Research has shown that longevity genes may be passed down through certain populations(Costa D,2019).However,genetics alone is not the decisive factor-environmental conditions also play a vital role in achieving a long life(Selinus O,2013).
基金supported by the National Natural Science Foundation of China(31621062 to W.W.,32070482 to X.Y.L.)Chinese Academy of Sciences(“Light of West China”to X.Y.L.,XDB13000000 to W.W.)。
文摘Butterflies are diverse in virtually all aspects of their ontogeny,including morphology,life history,and behavior.However,the developmental regulatory mechanisms underlying the important phenotypic traits of butterflies at different developmental stages remain unknown.Here,we investigated the developmental regulatory profiles of butterflies based on transposase accessible chromatin sequencing(ATAC-seq)at three developmental stages in two representative species(Papilio xuthus and Kallima inachus).
基金supported by the National Key R&D Program of China (Nos. 2016YFB0401801, 2016YFB0400803)the Science Challenge Project (No. TZ2016003)+1 种基金the National Natural Science Foundation of China (Nos. 61674138, 61674139, 61604145, 61574135, 61574134, 61474142, 61474110)the Beijing Municipal Science and Technology Project (No. Z161100002116037)
文摘GaN-based continuous-wave operated blue-violet laser diodes(LDs) with long lifetime are demonstrated, which are grown on a c-plane GaN substrate by metal organic chemical vapor deposition with a 10 × 600 μm^2 ridge waveguide structure.The electrical and optical characteristics of a blue-violet LD are investigated under direct-current injection at room temperature(25 °C). The stimulated emission wavelength and peak optical power of the LD are around 413 nm and over 600 mW, respectively.In addition, the threshold current density and voltage are as small as 1.46 kA/cm^2 and 4.1 V, respectively. Moreover, the lifetime is longer than 1000 hours under room-temperature continuous-wave operation.
文摘Prolongation of the QT interval is associated with adverse cardiac events specifically Torsades de pointes(TdP).There are multiple mediations that have a known,possible,or conditional risk for prolonged QT interval,but general practitioners’knowledge of these medications is unknown.We conducted a survey to assess internal medicine(IM)providers’knowledge of risk factors and medications associated with prolonged QT as well as provider experience and comfort when treating patients with prolonged QT.A 17-question,anonymous survey was constructed in 2019 and distributed to IM providers and residents at a tertiary care center.Questions included demographic information,6 Likert-scale questions gauging provider experience with prolonged QT,and 10 multiple choice clinical vignettes to assess clinical knowledge.Data was analyzed descriptively.Knowledge was assessed via clinical vignettes and compared by level of training.Forty-one responses were received out of a total of 87 possible respondents(47.1%response rate).About 70%of respondents see patients with acquired prolonged QT once monthly or more.95%rarely see congenital prolonged QT.When presented with QTc drug issues,73%of providers seldom or sometimes consulted pharmacy,but about half used online resources.The average correct score on the clinical vignettes was 5.59/10,with the highest scores seen in attending physicians in their first five years of practice(6.96/10).Our survey suggests that IM providers commonly encounter QT prolonging drugs.Educational efforts to improve knowledge of drug and patient risk factors for TdP may be needed.
文摘Baosteel No. 3 BF has been running smoothly and stably for more than 18 years and has become China＇ s longest-life blast furnace, producing many advanced economical and technical indexes. Comprehensive longevity technology has been developed in terms of the design, operation, and maintenance of the No. 3 BF during the prolonged period of research and practice. To obtain stable and smooth operation and to prolong the campaign life, the following measures have been taken： appropriate designing of the furnace profile and cooling system; improving raw material quality and optimizing the operating system; improving the cooling intensity and water quality;and adopting various longevity maintenance measures to ensure the safety of the body and the hearth temperature.
基金The study was reviewed and approved by the Wayne State University Institutional Review Board(Protocol Number:IRB-20-04-2126).
文摘BACKGROUND The Coronavirus Disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 virus is an international health concern with substantial morbidity and mortality.COVID-associated cystitis(CAC),presents as new onset or exacerbated urinary symptoms,resembling overactive bladder(OAB)symptoms.AIM To examines the long-term outcomes of patients with CAC in the context of Long COVID.METHODS A cohort of 350 patients admitted to Detroit Hospitals with COVID-19 between May and December 2020,displaying CAC symptoms following discharge,was prospectively followed.Initial urologic evaluations occurred at 10-14 wk and were repeated at 21-28 mo postdischarge.Symptoms were managed conservatively,employing behavioral modifications and standard OAB medications.Participants completed surveys assessing urinary symptoms and quality of life(QoL)at both time points.The primary outcome was the Urology Care Foundation Overactive Bladder Assessment Tool.RESULTS 87%of the final cohort(n=310)reported symptom improvement at 21-28 mo post-discharge.Patients with new onset CAC symptoms showed a median decrease of 9-10 points in OAB and QoL scores,while those with existing symptoms experienced a decrease of 6 points.Overall,95.4%of patients with new onset symptoms reported symptom improvement at follow-up,contrasting with 60.7%among those with existing symptoms.CONCLUSION This study presents the first long-term follow-up of adult patients with CAC,revealing a promising prognosis with conservative management measures in the context of Long COVID.These findings provide reassurance to patients regarding symptom resolution and underscore the need for further research into this evolving aspect of COVID-19's impact on urological health.
文摘Aim:?To explore the longer term blood glucose self-monitoring outcomes and frequency of monitoring for outpatients with diabetes type 1 after completion of the Dose Adjustment for Normal Eating (DAFNE) course. The hypothesis was that DAFNE outcomes would differ according to frequency of glucose monitoring.Methods:?A?sequential data-triangulation design using existing?baseline (T0) and 12-months (T12)?DAFNE course data and interview data from 12 randomly selected participants who had completed the course two years ago.?Results: Age range was 23 to 70 years with HbA1c 6.1% to 12.6% at T0?and 6.1% to 11.4% at T12. Comparisons of HbA1c, PAID, HAD subscales?anxiety?and?depression,?and covariate data between T0?and T12indicatedsignificant reductions in the mean depression and PAID scores (both?P?< 0.001) for the whole group. For the two groups who recorded their blood glucose less than three times or three or more times per day, changes were not significantly different. For both groups, the trend between T0?and T12?was downwards for change in mean blood glucose level and all survey scales. The proportion of all participants with T12?HbA1c at or below their T0?value was greater than 50% (Proportion = 69%, 95% CI: 56% - 79%) but only the highest HbA1c tertile group showed a significant difference (P?= 0.003). There was an average decrease in the incidence of hypoglycaemic events of 0.6 overall: The greatest change was for the high HbA1c tertile with a mean decrease of 0.8. The interview data suggested that DAFNE graduates experimented more with food, exercise, and insulin;gained knowledge;learnt personal body needs;increased awareness of blood glucose level;gained confidence and improved their quality of life. Conclusions: There was insufficient evidence to conclude that frequency of blood glucose monitoring influenced metabolic control. However, people with type 1 diabetes who undertake the less restricted DAFNE approach to diabetes self-management can improve their quality of life and glycaemic control.
文摘The exploration of human life and health is advancing with the changes of the times.With the growth of age,the occurrence of chronic diseases of human immunity and organ system is frequent,which has a serious impact on human health.Genes,environment and other random factors determine the outcome of longevity,and intestinal flora is considered to be a decisive factor affecting human health and longevity,mainly because of its huge impact on human immunity,growth and development.The study of the relationship between intestinal flora and longevity is beneficial to improve the health status of the elderly and improve the overall life level of human beings,which has great scientific research value.This review will review the role of intestinal flora in longevity.
基金supported by the National Natural Science Foundation of China(32101701,32470273,32170268)Hubei Provincial Natural Science Foundation of China for Excellent Young Scientists(2024 AFA100)+1 种基金National 111 Project of the Ministry of Education of China(BP0820035)an Initiative Grant of Hubei University of Technology for High-level Talents(GCC20230001).
文摘During long-term evolution,plants have signified a shift in their life-history strategy from perenniality to annuality to rapidly complete their reproduction in variable climatic environments.However,as the human population is rapidly increasing and fossil fuels are being increasingly consumed,it becomes essential to develop low-carbon agriculture and sustainable industries.Therefore,it is important to improve plant perennial flowering behavior to upgrade biomass production and maintain biodiversity as a green revolution and carbon neutralization strategy[1].
文摘Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.
文摘Herein,manganese(Mn)‑doped poly(1,5‑diaminonaphthalene)(PN)electrode material(Mn@PN)was synthesized via chemical oxidative polymerization.The material′s distinctive vesicular architecture enables rapid ion transport while maintaining the structural stability of the electrode under continuous charge‑discharge cycles.Electrochemical characterization under a three‑electrode system revealed exceptional rate capability:Mn@PN delivered an ultrahigh specific capacitance of 10318 F·g^(-1) at a low current density of 3 A·g^(-1) and retained 9415 F·g^(-1)(91.2%retention compared to the value at 3 A·g^(-1))even at an ultrahigh current density of 50 A·g^(-1).Moreover,the material exhibited 97.4%capacitance retention after 9000 cycles at 30 A·g^(-1),corresponding with a low capacitance decay rate of 0.003‰per cycle,significantly outperforming conventional conductive polymers like polyaniline(PANI).An asymmetric supercapacitor assembled with Mn@PN as the positive electrode(Mn@PN||AC)achieved an energy density of 328 Wh·kg^(-1) at 15 A·g^(-1) and retained 80.7%of its initial specific capacitance after 4000 cycles at 20 A·g^(-1).
基金Supported by the National Natural Science Foundation of China(No.82071571)the Natural Science Foundation of Guangdong Province(No.2021A1515010601)+3 种基金Guangdong Provincial Basic and Applied Basic Research Foundation-Dongguan Joint Fund(No.2024A1515140121)the“Climbing”Program of Guangdong Province(No.pdjh2021b0226)the Innovation and Entrepreneurship Program for College Students(No.GDMU2022038,202310571038,ZZDC002,S202510571041)Guangdong Medical University Undergraduate Innovation and Entrepreneurship Education Base Project(No.JDXM2024039,JDXM2025046)。
文摘Genomic destabilization and defective DNA repair are the most prominent features of tumour cells and are exploited by various chemotherapy drugs for cancer therapy.Long non-coding RNA(lncR-NAs)have emerged as powerful regulators of gene expression and are thus involved in diverse biological processes.Recent studies have demonstrated that several lncRNAs play critical roles in DNA repair.Nonetheless,the relationship between DNA damage-responsive lncRNAs and chemoresistance remains poorly defined.In this study,we established four different DNA damage models triggered by cisplatin(DDP),H2O2,neocarzinostatin(NCS)or ultraviolet(UV)irradiation and identified a specific upregu-lated lncRNA(lnc-DUSP6)involved in the cisplatin-induced DNA damage response.Furthermore,loss-or gain-of-function experiments confirmed that lnc-DUSP6 enhanced DNA repair and cell survival under cisplatin treatment,thus promoting cisplatin resistance.Mechanistically,an RNA immunoprecipitation(RIP)assay revealed that lnc-DUSP6 directly interacts with DUSP6(Dual Specificity Phosphatase 6),which is closely associated with cisplatin sensitivity.Additionally,overexpression of DUSP6 significantly rescued the effects of lnc-DUSP6 silencing on DNA repair and cell survival under cisplatin treatment.O-verall,our results show the effect and underlying mechanism of lnc-DUSP6 in cisplatin resistance:lnc-DUSP6 promotes cisplatin-induced DNA damage repair and cisplatin resistance by stabilizing DUSP6,which is highly clinically important for enhancing the efficacy of cisplatin for cancers.
文摘In a recent paper published in a special issue of Integrative Zoology on‘Paleontology and evolution–part I.’(Palombo 2014),the author(van der Geer 2014)takes a review of the derived traits observed in endemic fossil insular mammals,including body size variation,cranial and postcranial changes,and modifications in dentition.At one point in the discussion,the author misinterprets and seriously distorts statements by Jordana et al.(2012)on the relationship between hypsodonty and longevity in the fossil insular bovid Myotragus balearicus Bate,1909.
基金supported by grants from the National Natural Science Foundation of China(No.81771748)the Shenzhen Science and Technology Project(No.JCYJ20180504170414637)+1 种基金Futian Healthcare Research Project(No.FTWS2021005)the Sanming Project of Medicine in Shenzhen(No.SZSM201602087)to Yue Zhang.
文摘Introduction The pursuit of optimal health and longevity is a long-standing human aspiration[1,2].Advances in public health policies and population medicine have significantly extended life expectancy,which has tripled from 20–30 years a century and a half ago.However,this has also led to an increase in age-related diseases.As we age,stem cells,the foundation of every organ and tissue in our body,lose their regenerative capacity,leading to tissue decline and age-related diseases.Environmental conditions and disease treatments can also negatively impact the quality of life and health span[3].
基金Project supported by the National Natural Science Foundation of China(12374181)Fundamental Research Funds for Public Universities in Liaoning(LJ212410140035,LJ212410140037,LJ212410140048)+2 种基金Shenyang Science and Technology Bureau(22-315-6-06)General Project of the Department of Education of Liaoning Province(LJKZ0084)Liaoning Province Science and Technology Plan Joint Program(Natural Science Foundation General Project,2024-MSLH-188)。
文摘Long-afterglow photocatalytic technology offers promising potential fo r all-weather pollutant treatment,yet its efficiency is often constrained by competition between afterglow emission and photocatalytic reactions.To address this,we developed a Pr^(3+)-doped Ca_(2)Al_(2)SiO_(7)(CASO)photocatalyst enriched with oxygen vacancies(V_(O)).The introduction of oxygen vacancies significantly increases trap concentration,enhancing both the intensity and du ration of the afterglow emission.A persulfate-assisted photo-Fenton system was designed based on V_(O)-CASO:Pr^(3+)enabling the self-activated degradation of tetracycline hydrochloride(TC)under ultraviolet afterglow.The photo-Fenton reaction consumes excess holes accumulated during the afterglow process,improving carrier utilization efficiency and mitigating rapid recombination.Additionally,persulfate addition can enrich reactive species and facilitate the Fe^(2+)/Fe^(3+)cycle.Benefiting from these synergistic effects,V_(O)-CASO:Pr^(3+)has achieved 75%TC degradation within1 h,significantly outperforming traditional systems.This study provides a new strategy for enhancing long-afterglow photocatalytic performance,paving the way for sustainable pollutant degradation technologies.
基金Chung Shan Medical University, Taichung city, Taiwan China, for its support。
文摘Long COVID is characterized by a group of persistent symptoms following the acute SARS-COV2 infection, which presented a multifaceted challenge to the healthcare systems all over the globe. The long COVID symptoms span various organ systems including the respiratory, cardiovascular, gastrointestinal, and neurological manifestations. Mitochondrial dysfunction and immune dysregulation play crucial roles in the long COVID pathophysiology. Recently nutritional intervention gained much attention in managing post-viral syndromes. Effective interventions like supplementation of omega-3 fatty acid, macro and micro nutrients, and vitamins help to reduce systemic inflammation and counteract muscle wasting. Other approaches like nutritional recovery, dietetic interventions, continuous nutritional care post-hospital discharge, nutritional rehabilitation programs,whole-diet approaches like Mediterranean diet, plant-based diet, and caloric optimization, improve overall functional recovery. Physical activity and exercise regimes have been shown to improve fatigue, dyspnea, and cognitive function. Tailored exercise regimes may promote safe rehabilitation. Certain ineffective interventions,such as non-personalized approaches, high dose of antioxidants, use of herbal products that are not clinically validated need to be addressed. Dietary interventions such as personalized nutritional counseling have been demonstrated to improve physical performance in long COVID patients. Further research is needed to refine protocols and identify optimal combinations of dietary and movement-based therapies to support the recovery of long-COVID patients. This narrative review focuses on the ongoing researches that reveals the intricate relationship between nutrition and long COVID recovery and also establishes effective protocols for nutritional care.
基金supported by the Science and Technology Program in Guangxi Province(2023JJD140004).
文摘Objective:The contribution of long non-coding RNAs(lncRNAs)associated with protein palmitoylation to the progression of hepatocellular carcinoma(HCC)remains largely unclear.This study sought to establish a prognostic signature based on palmitoylation-related lncRNAs and explore their functional implications in HCC.Methods:RNA sequencing and clinical data for HCC and normal tissues were sourced from the Cancer Genome Atlas(TCGA).Pearson correlation analysis was used to identify lncRNAs that were co-expressed with palmitoylation-related genes.Univariate Cox regression was applied to select lncRNAs with prognostic value,followed by the construction of a predictive model using the least absolute shrinkage and selection operator(LASSO)regression.A focused analysis was performed on one key lncRNA,AC009403.1.Expression levels of the final nine lncRNAs included in the model were further validated by reverse transcription quantitative polymerase chain reaction(RT-qPCR).Results:A prognostic model for HCC was developed using nine palmitoylation-associated lncRNAs:AC009403.1,AC010789.1,AC026402.2,AC107021.2,AC135050.6,AL353572.4,MKLN1-AS,PRRT3-AS1,and ZNF582-AS1.This model effectively stratified patients into high-and low-risk groups exhibiting significantly different overall survival(OS)and progression-free survival(PFS),with the low-risk group showing more favorable outcomes.The high-risk group was associated with an immunosuppressive microenvironment,higher tumor mutation burden(TMB),and increased sensitivity to certain chemotherapeutic drugs(e.g.,Sorafenib).Finally,RT-qPCR validation revealed that all nine lncRNAs were significantly upregulated in HCC tissues.Conclusion:The nine-lncRNA signature exhibits robust predictive power for HCC prognosis and provides novel insights into the mechanisms of lncRNA-regulated palmitoylation in HCC development.
基金supported in part by AFRI grant numbers 2019-7015-29321 and 2021-67015-33409 from the USDA National Institute of Food and Agriculture(NIFA)the SCINet project of the USDA ARS project number 0500-00093-001-00-D。
文摘Structural variations(SVs≥50 bp)are a critical but underexplored source of genetic diversity in cattle,shaping traits vital for productivity,adaptability,and health.Advances in long-read sequencing,pangenome graph construction,and near-complete genome assemblies now allow accurate SV detection and genotyping.These innovations overcome the limitations of single-reference genomes,enabling the discovery of complex SVs,including nested and overlapping variants,and providing access to previously inaccessible genomic regions such as centromeres and telomeres.This review highlights the current landscape of cattle SV research,with emphasis on integrating longread sequencing and pangenome frameworks to uncover breed-specific and population-level variation.While many SVs are linked to economically important traits such as feed efficiency and disease resistance,their broader regulatory impacts remain an active area of investigation.Emerging functional genomics approaches,including transcriptomics,epigenomics,and genome editing,will clarify how SVs influence gene regulation and phenotype.Looking forward,the integration of SV catalogs with multi-omics data,imputation resources,and artificial intelligence-driven models will be essential for translating discoveries into breeding and conservation applications.Integrating structural variants into breeding pipelines promises to revolutionize livestock genomics,enabling precision selection and sustainable agriculture despite challenges in cost,data sharing,and functional validation.
