Polyurethane-fluorinated polysiloxane(PU-^(F)PDMS)with high-strength,high-bonding and low surface en-ergy is synthesized as the matrix,and the PU-^(F)PDMS/MCs/Ag marine anti-fouling coating on the sur-face of imitatio...Polyurethane-fluorinated polysiloxane(PU-^(F)PDMS)with high-strength,high-bonding and low surface en-ergy is synthesized as the matrix,and the PU-^(F)PDMS/MCs/Ag marine anti-fouling coating on the sur-face of imitation crab shells is constructed by assembling butenolide@1,1-stilbene-modified hydrolyzed polyglycidyl methacrylate/graphene oxide microcapsules(Bu@PGMAm/GO MCs)with compact multi-shell structure and Ag nanoparticles(AgNPs)step by step on the PU-^(F)PDMS matrix.The PU-^(F)PDMS/MCs/Ag bionic anti-fouling coatings achieve long-term and stable anti-fouling effect under the combination of robust low-surface-energy PU-^(F)PDMS matrix,steady-state sustained release of butenolide encapsulated by the compact multi-shell,bionic surface formed by the microcapsules and AgNPs,and the release of Ag^(+).The shear strength,tensile strength,and elongation at break of the PU-^(F)PDMS/MCs/Ag are 3.53 MPa,6.7 MPa,and 192.83%,respectively.Its static contact angle and sliding angle are 161.8°and 3.6°,respectively.The antibacterial rate of PU-^(F)PDMS/MCs/Ag against Escherichia coli,Staphylococcus aureus,and Candida albicans can reach 100%.Compared with glass blank,PU,PU-^(F)PDMS,PU-^(F)PDMS/Ag,and PU-^(F)PDMS/MCs,both the adhesion number and coverage percentage of chlorella adhere to PU-^(F)PDMS/MCs/Ag are the minimum values,which are 600 cell mm^(-2) and 1.53%,respectively.After 6 months of marine field test,the primer blank,PU,PU-^(F)PDMS all show different degrees of attachment by shellfish,spirorbis,al-gae and other biofouling,while the PU-^(F)PDMS/MCs/Ag coating is still not covered with biofouling,while the PU-^(F)PDMS/MCs/Ag coatings still exhibit little attachment of marine fouling.The PU-^(F)PDMS/MCs/Ag bionic anti-fouling coatings are expected to be widely used in the fields of anti-fouling,anti-icing,anti-fogging,drag reduction,self-cleaning,and antibacterial.展开更多
The influence of the squeeze film between the tube and the support structure on flow-induced vibrations is a critical factor in tube bundles subjected to two-phase cross-flow.This aspect can significantly alter the th...The influence of the squeeze film between the tube and the support structure on flow-induced vibrations is a critical factor in tube bundles subjected to two-phase cross-flow.This aspect can significantly alter the threshold for fluidelastic instability and affect heat transfer efficiency.This paper presents a mathematical model incorporating the squeeze film force between the tube and the support structure.We aim to clarify the mechanisms underlying fluidelastic instability in tube bundle systems exposed to two-phase flow.Using a self-developed computer program,we performed numerical calculations to examine the influence of the squeeze film on the threshold of fluidelastic instability in the tube bundle system.Furthermore,we analyzed how the thickness and length of the squeeze film affect both the underlying mechanisms and the critical velocity of fluidelastic instability.展开更多
Objective:Triple-negative breast cancer(TNBC)is a highly aggressive subtype that lacks targeted therapies,leading to a poorer prognosis.However,some patients achieve long-term recurrence-free survival(RFS),offering va...Objective:Triple-negative breast cancer(TNBC)is a highly aggressive subtype that lacks targeted therapies,leading to a poorer prognosis.However,some patients achieve long-term recurrence-free survival(RFS),offering valuable insights into tumor biology and potential treatment strategies.Methods:We conducted a comprehensive multi-omics analysis of 132 patients with American Joint Committee on Cancer(AJCC)stage III TNBC,comprising 36 long-term survivors(RFS≥8 years),62 moderate-term survivors(RFS:3-8 years),and 34 short-term survivors(RFS<3 years).Analyses investigated clinicopathological factors,whole-exome sequencing,germline mutations,copy number alterations(CNAs),RNA sequences,and metabolomic profiles.Results:Long-term survivors exhibited fewer metastatic regional lymph nodes,along with tumors showing reduced stromal fibrosis and lower Ki67 index.Molecularly,these tumors exhibited multiple alterations in genes related to homologous recombination repair,with higher frequencies of germline mutations and somatic CNAs.Additionally,tumors from long-term survivors demonstrated significant downregulation of the RTK-RAS signaling pathway.Metabolomic profiling revealed decreased levels of lipids and carbohydrate,particularly those involved in glycerophospholipid,fructose,and mannose metabolism,in long-term survival group.Multivariate Cox analysis identified fibrosis[hazard ratio(HR):12.70,95%confidence interval(95%CI):2.19-73.54,P=0.005]and RAC1copy number loss/deletion(HR:0.22,95%CI:0.06-0.83,P=0.026)as independent predictors of RFS.Higher fructose/mannose metabolism was associated with worse overall survival(HR:1.30,95%CI:1.01-1.68,P=0.045).Our findings emphasize the association between biological determinants and prolonged survival in patients with TNBC.Conclusions:Our study systematically identified the key molecular and metabolic features associated with prolonged survival in AJCC stage III TNBC,suggesting potential therapeutic targets to improve patient outcomes.展开更多
We are intrigued by the issues of shock instability,with a particular emphasis on numerical schemes that address the carbuncle phenomenon by reducing dissipation rather than increasing it.For a specific class of plana...We are intrigued by the issues of shock instability,with a particular emphasis on numerical schemes that address the carbuncle phenomenon by reducing dissipation rather than increasing it.For a specific class of planar flow fields where the transverse direction exhibits vanishing but non-zero velocity components,such as a disturbed onedimensional(1D)steady shock wave,we conduct a formal asymptotic analysis for the Euler system and associated numerical methods.This analysis aims to illustrate the discrepancies among various low-dissipative numerical algorithms.Furthermore,a numerical stability analysis of steady shock is undertaken to identify the key factors underlying shock-stable algorithms.To verify the stability mechanism,a consistent,low-dissipation,and shock-stable HLLC-type Riemann solver is presented.展开更多
High microsatellite instability(MSI-H)colorectal cancer(CRC),caused by deficient mismatch repair,accounts for about 15%of all CRC cases and is more common in right-sided tumors.While early-stage MSI-H CRC has a relati...High microsatellite instability(MSI-H)colorectal cancer(CRC),caused by deficient mismatch repair,accounts for about 15%of all CRC cases and is more common in right-sided tumors.While early-stage MSI-H CRC has a relatively good prognosis,advanced cases often respond poorly to standard chemotherapy.Immune checkpoint inhibitors,such as pembrolizumab,have shown strong and lasting effects in MSI-H CRC.Pembrolizumab is now approved as a first-line treatment for metastatic MSI-H CRC due to its superior outcomes compared to traditional chemotherapy.CASE SUMMARY A 44-year-old male with MSI-H transverse colon cancer presented with hematochezia,abdominal pain,and significant weight loss.Imaging revealed a bulky tumor with invasion of adjacent structures and multiple liver lesions.A diverting ileostomy was performed followed by 36 cycles of pembrolizumab.The patient achieved a clinical and radiologic complete response.One month after completing the treatment,the patient underwent laparoscopic right hemicolectomy.A spontaneous transection of the colon at the original tumor site was unexpectedly identified.Final pathology confirmed pathological complete response(ypT0N0)with fibrosis.The patient recovered well after surgery,and follow-up showed no evidence of recurrence.CONCLUSION Immune checkpoint inhibitors may cause delayed structural damage to bowel tissue even after apparent complete tumor regression.展开更多
Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery complications.Despite the effectiveness of initial treatments,such as intravenous immunoglobulin,KD pat...Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery complications.Despite the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical Cases.This editorial emphasizes the critical need for long-term management and regular surveillance to prevent such complications.By drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.展开更多
Mechanical snap-through instability of bi-stable structures may find many practical applications such as state switching and energy transforming.Although there exist diverse bi-stable structures capable of snap-throug...Mechanical snap-through instability of bi-stable structures may find many practical applications such as state switching and energy transforming.Although there exist diverse bi-stable structures capable of snap-through instability,it is still difficult for a structure with high slenderness to undergo the axial snap-through instability with a large stroke.Here,an elastic structure with high slenderness is simply constructed by a finite number of identical,conventional bi-stable units with relatively low slenderness in series connection.For realizing the axial snap-through instability with a large stroke,common scissors mechanisms are further introduced as rigid constraints to guarantee the synchronous snap-through instability of these bi-stable units.The global feature of the large-stroke snap-through instability realized here is robust and even insusceptible to the local out-of-synchronization of individual units.The present design provides a simple and feasible way to achieve the large-stroke snap-through instability of slender structures,which is expected to be particularly useful for state switching and energy transforming in narrow spaces.展开更多
Extensive spatiotemporal analyses of long-trend surface ozone in the Yangtze River Delta(YRD)region and itsmeteorology-related and emission-related have not been systematically analyzed.In this study,by using 8-year-l...Extensive spatiotemporal analyses of long-trend surface ozone in the Yangtze River Delta(YRD)region and itsmeteorology-related and emission-related have not been systematically analyzed.In this study,by using 8-year-long(2015–2022)surface ozone observation data,we attempted to reveal the variation ofmultiple timescale components using the Kolmogorov–Zurbenko filter,and the effects of meteorology and emissions were quantitatively isolated using multiple linear regression with meteorological variables.The results showed that the short-term,seasonal,and long-term components accounted for daily maximum 8-hr average O_(3)(O_(3–8)hr)concentration,46.4%,45.9%,and 1.0%,respectively.The meteorological impacts account for an average of 71.8%of O_(3–8)hr,and the YRD’s eastern and northern sections aremeteorology-sensitive areas.Based on statistical analysis technology with empirical orthogonal function,the contribution of meteorology,local emission,and transport in the long-term component of O_(3–8)hr were 0.21%,0.12%,and 0.6%,respectively.The spatiotemporal analysis indicated that a distinct decreasing spatial pattern could be observed from coastal cities towards the northwest,influenced by the monsoon and synoptic conditions.The central urban agglomeration north and south of the YRD was particularly susceptible to local pollution.Among the cities studied,Shanghai,Anqing,and Xuancheng,located at similar latitudes,were significantly impacted by atmospheric transmission—the contribution of Shanghai,the maximum accounting for 3.6%.展开更多
The utilization of Inlet Guide Vane (IGV) plays a key factor in affecting the instability evolution. Existing literature mainly focuses on the effect of IGV on instability inception that occurs in the rotor region. Ho...The utilization of Inlet Guide Vane (IGV) plays a key factor in affecting the instability evolution. Existing literature mainly focuses on the effect of IGV on instability inception that occurs in the rotor region. However, with the emergence of compressor instability starting from the stator region, the mechanism of various instability inceptions that occurs in different blade rows due to the change of IGV angles should be further examined. In this study, experiments were focused on three types of instability inceptions observed previously in a 1.5-stage axial flow compressor. To analyze the conversion of stall evolutions, the compressor rotating speed was set to 17 160 r/min, at which both the blade loading in the stator hub region and rotor tip region were close to the critical value before final compressor stall. Meanwhile, the dynamic test points with high-response were placed to monitor the pressures both at the stator trailing edges and rotor tips. The results indicate that the variation of reaction determines the region where initial instability occurs. Indeed, negative pre-rotation of the inlet guide vane leads to high-reaction, initiating stall disturbance from the rotor region. Positive pre-rotation results in low-reaction, initiating stall disturbance from the stator region. Furthermore, the type of instability evolution is affected by the radial loading distribution under different IGV angles. Specifically, a spike-type inception occurs at the rotor blade tip with a large angle of attack at the rotor inlet (−2°, −4° and −6°). Meanwhile, the critical total pressure ratio at the rotor tip is 1.40 near stall. As the angle of attack decreases, the stator blade loading reaches its critical boundary, with a value of approximately 1.35. At this moment, if the rotor tip maintains high blade loading similar to the stator hub, the partial surge occurs (0° and +2°);otherwise, the hub instability occurs (+4° and +6°).展开更多
Rotating Instability (RI) is a typical unsteady flow phenomenon in compressors and may cause severe aerodynamic noise and even potential nonsynchronous vibration. Most studies of RI are based on the uniform inflow, ig...Rotating Instability (RI) is a typical unsteady flow phenomenon in compressors and may cause severe aerodynamic noise and even potential nonsynchronous vibration. Most studies of RI are based on the uniform inflow, ignoring the influence of inlet distortions. This study investigates the mechanism of RI in a transonic rotor through full-annulus unsteady simulations, with a particular focus on the effects of boundary layer ingesting distortions. The results show that at the uniform inflow, the RI fluctuations with the broadband hump can be observed over a relatively wide mass flow rate range, and its origin can be attributed to the coupling effect between the tip leakage flow and shear layer instability. At the inlet distortions, the broadband hump only occurs with partial circumferential locations. This kind of flow phenomenon is defined as Partial Rotating Instability (PRI). The PRI only occurs in a narrower mass flow rate range in which the circumferential range of strong shear is sufficiently large and the self-induced unsteady effects are strong enough. Further, this study confirms that the averaged tip leakage flow axial momentum at the onset of RI or PRI is close, so it can be used as the parameter to determine whether RI or PRI occurs.展开更多
A hydrodynamic model is used to study Kelvin-Helmholtz(KH)instability of the interface between two particle-laden inviscid fluids moving with two different uniform mean velocities.Explicit eigen-equation is derived to...A hydrodynamic model is used to study Kelvin-Helmholtz(KH)instability of the interface between two particle-laden inviscid fluids moving with two different uniform mean velocities.Explicit eigen-equation is derived to study the effect of suspended particles on the growth rate of KH instability.For dusty gases with negligible volume fraction of heavy particles and small particle-to-fluid mass ratio,the real and imaginary parts of leading-order asymptotic expression derived by the present model for the growth rate are shown to be identical to the earlier results derived by the classical Saffman model established for dusty gases.Beyond the known results,explicit leading-order asymptotic expressions for the effect of suspended particles on the growth rate are derived for several typical cases of basic interest.It is shown that the suspended particles can decrease or increase the growth rate of KH instability depending on the Stokes numbers of the particles and whether the particles are heavier or lighter than the clean fluid.Compared to the mass density of the clean fluid,our results based on leading-order asymptotic solutions show that heavier particles and lighter particles have opposite effects on the growth rate of KH instability,while the effect of neutrally buoyant particles on the growth rate of KH instability is negligible.展开更多
Slow-release phosphate materials were prepared by activating insoluble phosphate with organic acid to stabilize high concentrations of Cd and Zn in contaminated smelter soil.The results showed that oxalic acid(0.1 mol...Slow-release phosphate materials were prepared by activating insoluble phosphate with organic acid to stabilize high concentrations of Cd and Zn in contaminated smelter soil.The results showed that oxalic acid(0.1 mol/L)activated tricalcium phosphate(TO-0.1)provided the most efficient stabilization of Cd and Zn.After 30 d treatment,leaching concentrations of Cd and Zn in soil were decreased from 3.17 and 16.60 mg/L to 0.078 and 0.32 mg/L,respectively.The acid-soluble fractions of Cd and Zn were transformed into reducible,oxidizable,and residual fractions.Notably,As mobility in TO-0.1 treated soils did not increase.In addition,acid rain leaching and 150 d of natural aging revealed that the slow-release phosphate material provided long-term stability for the stabilization of Cd and Zn.This study verifies the potential application of slow-release phosphate materials for the remediation of heavy metal contaminated soil at smelting sites.展开更多
Objective: To analyze the clinical manifestations of intraocular lens (IOL) opacity after cataract surgery through case reports, and to explore its pathogenesis and diagnosis and treatment ideas, so as to provide a ba...Objective: To analyze the clinical manifestations of intraocular lens (IOL) opacity after cataract surgery through case reports, and to explore its pathogenesis and diagnosis and treatment ideas, so as to provide a basis for the early diagnosis and correct treatment of IOL opacity. Methods: The clinical data of one patient diagnosed with IOL opacity and underwent intraocular lens replacement in the Department of Ophthalmology, Affiliated Hospital of Youjiang Medical College for Nationalities in December 2023 were reported. The characteristics of IOL opacity were observed, and the research progress and pathogenesis of IOL opacity were understood by consulting the literature. Results: This patient is the first case of IOL opacity in our hospital. The specific reason is unclear. It is considered to be related to the IOL material. Conclusion: Hydrophilic acrylic IOL is widely used in clinic because of its good histocompatibility. However, due to its hydrophilicity, there are more cases of IOL opacity than other types of IOL. At present, there is no unified conclusion on the etiology and mechanism of IOL opacity. IOL opacity can seriously affect vision and is easily misdiagnosed as a posterior cataract. We should fully disperse the large pupil and carefully observe under the slit lamp. The most effective treatment for this disease is IOL replacement.展开更多
The Yangtze River Delta(YRD)region has witnessed a consistent decrease in NO_(2),CO,and PM_(2.5) from 2016 to 2023.However,ozone has exhibited fluctuating patterns.Quantifying ozone contributions from emissions,both w...The Yangtze River Delta(YRD)region has witnessed a consistent decrease in NO_(2),CO,and PM_(2.5) from 2016 to 2023.However,ozone has exhibited fluctuating patterns.Quantifying ozone contributions from emissions,both within and outside the YRD,is essential for understanding city-cluster-scale ozone pollution(CCSOP).To address these concerns,a comprehensive approach combining Kolmogorov-Zurbenko filtering,Empirical Orthogonal Function,Absolute Principal Component Score,andMultiple Linear Regression methods(KZ-EOF-APCs-MLR)was employed to quantify the impacts of meteorological factors,local and non-local emission contributions of ozone(LECO and NECO).Emission changes were identified as the predominant factor shaping annual fluctuations in ambient ozone.Notably,during the previous andmiddle stages of the COVID-19 pandemic(from2017 to 2021),emissions reductions led to a marked decrease in YRD ozone levels(-7.01μg/m^(3)),with a pronounced rebound post-pandemic(2022 to 2023)(+8.04μg/m^(3)).Seasonally,the emissioninduced ozone exhibited fluctuating upward trend during autumn and winter,suggesting a transition of ozone pollution towards colder seasons.Spatially,high LECO concentrated in the eastern YRD(EYRD)across spring,autumn,and winter,becoming prominent in the central YRD(CYRD)during summer.During CCSOP,the CYRD exhibited the highest LECO and exceedance frequency(20.82μg/m^(3) and 45.27%).LECO explained a large portion of ozone variability during CCSOP,particularly in the EYRD,while NECO showed less explanatory power but consistently high contributions(148.05±15.52μg/m^(3)).These findings offer valuable insights for a deeper understanding of the evolving patterns of ozone pollution and the issue of CCSOP in the YRD.展开更多
To better understand the spatial variations in phytoplankton abundance and community structure and their relationship with environmental parameters in Jiaozhou Bay,Yellow Sea,in Shandong,East China,observations were c...To better understand the spatial variations in phytoplankton abundance and community structure and their relationship with environmental parameters in Jiaozhou Bay,Yellow Sea,in Shandong,East China,observations were conducted to estimate abundance of net-phytoplankton and key groups along with environmental parameters in three typical sites in seasonal survey from 2004 to 2016 in the bay.The spatial patterns of phytoplankton abundance differed obviously between the inner and the outer bay.The abundance of total phytoplankton and diatoms increased obviously in the northern part of the bay,while decreased in the southern part and outer bay.An increase in dinoflagellate abundance was obvious in the outer bay.Variations in the dynamics of phytoplankton abundance could be largely explained by the succession of chain-forming diatoms and dinoflagellates.The key chain forming diatom groups Chaetoceros and Thalassiosira increased markedly,especially in winter in the northern part of the bay,while in the southern part and the outer bay,Chaetoceros declined.Besides,the key dinoflagellate groups Ceratium and Noctiluca increased noticeably,resulting in a significant increase in the dinoflagellate/diatom ratio in the outer bay.These variations has a significant correlation with environmental variables of surface seawater temperature,phosphorus,nitrogen,salinity,and N/Si ratio(P<0.05).For the key groups,temperature was the primary driver of dinoflagellate abundance,while the N/P ratio was critical for chain-forming diatoms.The abundance of phytoplankton showed a clear spatial pattern and associated obviously with environmental factors in the marine ecosystems,offering insights into coastal ecosystem management and conservation strategies.展开更多
This study was performed to investigate the changes in microbial communities and metabolites during the long-term fermentation of commercially manufactured anchovy sauce.Samples of commercial anchovy sauce were collec...This study was performed to investigate the changes in microbial communities and metabolites during the long-term fermentation of commercially manufactured anchovy sauce.Samples of commercial anchovy sauce were collected from large-scale fermentation tanks with fermentation periods of up to 7.87 years.The complex bacterial community was simplified to two genera,Tetragenococcus and Halanaerobium,after approximately 0.55 years of fermentation.Although genera,such as Saccharomyces,Cladosporium,Candida,and Aspergillus,were relatively dominant,no clear pattern was identified in fungal community analysis.The longitudinal metabolite profile demonstrated that approximately half(55.8%)of the metabolites present in anchovy sauce were produced within a year of fermentation due to rapid fermentation.Despite the static microbial community,the contents of several metabolites including amino acids and biogenic amines changed continuously during the long-term fermentation of anchovy sauce.This study provides novel insights into the changes in microbiota and metabolites in fish sauce produced without any starter inoculation.展开更多
Background:Long-term exposure to light has emerged as a novel risk factor for metabolic diseases.The whitening of brown adipose tissue(BAT)may play an important role in metabolic disorders caused by long-term continuo...Background:Long-term exposure to light has emerged as a novel risk factor for metabolic diseases.The whitening of brown adipose tissue(BAT)may play an important role in metabolic disorders caused by long-term continuous light exposure.This study aimed to investigate the morphological and functional alterations in BAT under continuous light conditions and to identify traditional Chinese medicine compounds capable of reversing these changes.Methods:A metabolic disorder model was established by subjecting mice to continuous light exposure for 5 weeks.During this period,body weight,food intake,and body fat percentage were monitored.Serum levels of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),and low density lipoprotein cholesterol(LDL-C)were measured to assess lipid metabolism.Histological changes in BAT were examined using H&E staining.The expression of the thermogenic marker uncoupling protein 1(UCP1)in BAT was determined by RT-qPCR and Western blot to evaluate thermogenic function.RNA sequencing(RNA-seq)was employed to identify differentially expressed genes(DEGs)involved in BAT whitening induced by prolonged continuous light exposure.DEGs were analyzed using the connectivity map(CMap)database to identify potential preventive and therapeutic compounds.The therapeutic efficacy of the selected compounds was subsequently evaluated using the above indicators,and key pathways were validated through western blot analysis.Results:After 5 weeks of continuous light exposure,mice exhibited increased body fat percentage and serum levels of TG,impaired mitochondrial function,reduced thermogenic capacity,and whitening of BAT.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)enrichment analyses indicated that BAT whitening was primarily associated with the adenosine 5'-monophosphate-activated protein kinase(AMPK)signaling pathway,fatty acid metabolism,and circadian rhythm.Ten hub genes identified using Cytoscape were mainly related to AMPK signaling and heat shock proteins.In vivo experiments showed that cordycepin significantly attenuated the increase in body fat percentage caused by prolonged light exposure.This effect was mediated by activation of the AMPK/PGC-1α/UCP1 signaling pathway,which restored the multilocular morphology and thermogenic function of BAT.Conclusion:Cordycepin mitigates continuous light-induced BAT whitening and metabolic disturbances by activating the AMPK signaling pathway.展开更多
BACKGROUND Gastric cancer is a major global health issue,and the perioperative period critic-ally influences patient outcomes.The different effects of sevoflurane inhalation anesthesia and propofol total intravenous a...BACKGROUND Gastric cancer is a major global health issue,and the perioperative period critic-ally influences patient outcomes.The different effects of sevoflurane inhalation anesthesia and propofol total intravenous anesthesia on intraoperative stability,postoperative complications,and long-term oncologic outcomes in patients with gastric cancer undergoing radical gastrectomy remain unclear.AIM To compare the effects of sevoflurane inhalation anesthesia and propofol total in-travenous anesthesia on clinical outcomes,including intraoperative indicators,postoperative complications,adverse effects,pain scores,and survival.METHODS This single-center retrospective cohort study included 204 patients who underw-ent radical gastrectomy for gastric cancer from February 2019 to December 2022.Patients were assigned to either the sevoflurane group(n=103)or the propofol group(n=101)based on intraoperative anesthetic regimen.Standardized protoc-ols for anesthesia management,intraoperative monitoring,and postoperative analgesia were applied.Baseline characteristics;intraoperative metrics;adverse events;complications;Visual Analog Scale(VAS)scores at 2,4,6,24,and 48 hours;and survival outcomes were retrospectively collected.Group comparisons were performed usingχ2 for categorical variables,t test for continuous variables,RESULTS Baseline demographic and clinical characteristics were similar between groups.No significant differences were observed in intraoperative indicators or most 30-day postoperative outcomes,including length of stay,emergency department visits,and readmission rates.The propofol group showed elevated mean VAS pain score at 24 hours postoperatively,but no differences were found at other time points.The propofol group also had significantly higher postoperative nausea incidence and transiently higher systolic/diastolic blood pressure and heart rate at the time of incision than the sevoflurane group.No significant differences were seen in overall rates or severity of postoperative complications,intraoperative adverse events,or in overall survival and progression-free survival.CONCLUSION In patients undergoing radical gastrectomy for gastric cancer,sevoflurane and propofol anesthesia demonstrated similar profiles regarding intraoperative safety,postoperative complications,adverse events,postoperative pain,and long-term survival.The selection of anesthesia can be personalized without significantly affecting periop-erative or oncologic outcomes.展开更多
Solar radiation data forecasting algorithms are important,especially in developing countries,as vast solar power plants cannot measure reliable and constant solar irradiance.The challenges of solar irradiance predicti...Solar radiation data forecasting algorithms are important,especially in developing countries,as vast solar power plants cannot measure reliable and constant solar irradiance.The challenges of solar irradiance prediction may be resolved by machine learning using weather datasets.This study emphasises the daily and monthly global solar radiation data predictions of three locations,Pretoria,Bloemfontein,and Vuwani,at different provinces in South Africa with various solar radiation distributions.The study evaluated five different machine learning models.Forecasting models were established to evaluate global solar radiation,focusing on input data.The selected forecast models are centered on their ability to perform with time series data.These models use five years of data from meteorological parameters,such as global horizontal irradiance(GHI),relative humidity,wind speed and ambient temperature between 1 January 2018 and 31 December 2022.The datasets from these meteorological parameters are utilised for training and testing the employed algorithms,which are examined using five statistical metrics.Moreover,the inconsistency of the solar irradiance time series was equally assessed using the clearness index.The results from this study demonstrate that the R2 value recording 0.866 datasets in Bloemfontein of random forest algorithm presents the highest performance during the training processes for all models studied,while the random tree in Vuwani showed the lowest performance of R2 of 0.210 with other algorithms in testing processes.Additionally,the maximum solar radiation was found in December for both Pretoria and Bloemfontein,recorded as 5.347 and 5.844 kWh/m2/day,respectively,while it was 4.692 kWh/m2/day at Vuwani in January.Similarly,the average clearness index of 0.605,0.657 and 0.533 are obtained at Pretoria,Bloemfontein,and Vuwani,respectively.Among the three sites under study,the solar radiation and clearness index are higher in Bloemfontein.Therefore,the proposed algorithms could be used conveniently for short-and long-term solar power plants in South Africa.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52003148 and 52261045)the State Key Laboratory of Marine Resource Utilization in South China Sea,Hainan University(No.MRUKF2021023)+3 种基金the Key Research and Development Project of Shaanxi Province(No.2023-YBGY-475)the Key Scientific Research Project of Education Department of Shaanxi Province(No.22JS003)the Industrialization Project of the State Key Laboratory of Biological Resources and Ecological Environment(Cultivation)of Qinba Region(No.SXC-2310)the key cultivation project funds of Shaanxi University of Technology(No.SLGKYXM2201).
文摘Polyurethane-fluorinated polysiloxane(PU-^(F)PDMS)with high-strength,high-bonding and low surface en-ergy is synthesized as the matrix,and the PU-^(F)PDMS/MCs/Ag marine anti-fouling coating on the sur-face of imitation crab shells is constructed by assembling butenolide@1,1-stilbene-modified hydrolyzed polyglycidyl methacrylate/graphene oxide microcapsules(Bu@PGMAm/GO MCs)with compact multi-shell structure and Ag nanoparticles(AgNPs)step by step on the PU-^(F)PDMS matrix.The PU-^(F)PDMS/MCs/Ag bionic anti-fouling coatings achieve long-term and stable anti-fouling effect under the combination of robust low-surface-energy PU-^(F)PDMS matrix,steady-state sustained release of butenolide encapsulated by the compact multi-shell,bionic surface formed by the microcapsules and AgNPs,and the release of Ag^(+).The shear strength,tensile strength,and elongation at break of the PU-^(F)PDMS/MCs/Ag are 3.53 MPa,6.7 MPa,and 192.83%,respectively.Its static contact angle and sliding angle are 161.8°and 3.6°,respectively.The antibacterial rate of PU-^(F)PDMS/MCs/Ag against Escherichia coli,Staphylococcus aureus,and Candida albicans can reach 100%.Compared with glass blank,PU,PU-^(F)PDMS,PU-^(F)PDMS/Ag,and PU-^(F)PDMS/MCs,both the adhesion number and coverage percentage of chlorella adhere to PU-^(F)PDMS/MCs/Ag are the minimum values,which are 600 cell mm^(-2) and 1.53%,respectively.After 6 months of marine field test,the primer blank,PU,PU-^(F)PDMS all show different degrees of attachment by shellfish,spirorbis,al-gae and other biofouling,while the PU-^(F)PDMS/MCs/Ag coating is still not covered with biofouling,while the PU-^(F)PDMS/MCs/Ag coatings still exhibit little attachment of marine fouling.The PU-^(F)PDMS/MCs/Ag bionic anti-fouling coatings are expected to be widely used in the fields of anti-fouling,anti-icing,anti-fogging,drag reduction,self-cleaning,and antibacterial.
基金financially supported by the National Natural Science Foundation of China(Grant No.12072336).
文摘The influence of the squeeze film between the tube and the support structure on flow-induced vibrations is a critical factor in tube bundles subjected to two-phase cross-flow.This aspect can significantly alter the threshold for fluidelastic instability and affect heat transfer efficiency.This paper presents a mathematical model incorporating the squeeze film force between the tube and the support structure.We aim to clarify the mechanisms underlying fluidelastic instability in tube bundle systems exposed to two-phase flow.Using a self-developed computer program,we performed numerical calculations to examine the influence of the squeeze film on the threshold of fluidelastic instability in the tube bundle system.Furthermore,we analyzed how the thickness and length of the squeeze film affect both the underlying mechanisms and the critical velocity of fluidelastic instability.
基金supported by grants from the Medical Engineering Jiont Fund of the Fudan University(No.IDH2310117)。
文摘Objective:Triple-negative breast cancer(TNBC)is a highly aggressive subtype that lacks targeted therapies,leading to a poorer prognosis.However,some patients achieve long-term recurrence-free survival(RFS),offering valuable insights into tumor biology and potential treatment strategies.Methods:We conducted a comprehensive multi-omics analysis of 132 patients with American Joint Committee on Cancer(AJCC)stage III TNBC,comprising 36 long-term survivors(RFS≥8 years),62 moderate-term survivors(RFS:3-8 years),and 34 short-term survivors(RFS<3 years).Analyses investigated clinicopathological factors,whole-exome sequencing,germline mutations,copy number alterations(CNAs),RNA sequences,and metabolomic profiles.Results:Long-term survivors exhibited fewer metastatic regional lymph nodes,along with tumors showing reduced stromal fibrosis and lower Ki67 index.Molecularly,these tumors exhibited multiple alterations in genes related to homologous recombination repair,with higher frequencies of germline mutations and somatic CNAs.Additionally,tumors from long-term survivors demonstrated significant downregulation of the RTK-RAS signaling pathway.Metabolomic profiling revealed decreased levels of lipids and carbohydrate,particularly those involved in glycerophospholipid,fructose,and mannose metabolism,in long-term survival group.Multivariate Cox analysis identified fibrosis[hazard ratio(HR):12.70,95%confidence interval(95%CI):2.19-73.54,P=0.005]and RAC1copy number loss/deletion(HR:0.22,95%CI:0.06-0.83,P=0.026)as independent predictors of RFS.Higher fructose/mannose metabolism was associated with worse overall survival(HR:1.30,95%CI:1.01-1.68,P=0.045).Our findings emphasize the association between biological determinants and prolonged survival in patients with TNBC.Conclusions:Our study systematically identified the key molecular and metabolic features associated with prolonged survival in AJCC stage III TNBC,suggesting potential therapeutic targets to improve patient outcomes.
基金Project supported by the National Natural Science Foundation of China(Nos.12471367 and12361076)the Research Program of Science and Technology at Universities of Inner Mongolia Autonomous Region(Nos.NJZY19186,NJZY22036,and NJZY23003)。
文摘We are intrigued by the issues of shock instability,with a particular emphasis on numerical schemes that address the carbuncle phenomenon by reducing dissipation rather than increasing it.For a specific class of planar flow fields where the transverse direction exhibits vanishing but non-zero velocity components,such as a disturbed onedimensional(1D)steady shock wave,we conduct a formal asymptotic analysis for the Euler system and associated numerical methods.This analysis aims to illustrate the discrepancies among various low-dissipative numerical algorithms.Furthermore,a numerical stability analysis of steady shock is undertaken to identify the key factors underlying shock-stable algorithms.To verify the stability mechanism,a consistent,low-dissipation,and shock-stable HLLC-type Riemann solver is presented.
文摘High microsatellite instability(MSI-H)colorectal cancer(CRC),caused by deficient mismatch repair,accounts for about 15%of all CRC cases and is more common in right-sided tumors.While early-stage MSI-H CRC has a relatively good prognosis,advanced cases often respond poorly to standard chemotherapy.Immune checkpoint inhibitors,such as pembrolizumab,have shown strong and lasting effects in MSI-H CRC.Pembrolizumab is now approved as a first-line treatment for metastatic MSI-H CRC due to its superior outcomes compared to traditional chemotherapy.CASE SUMMARY A 44-year-old male with MSI-H transverse colon cancer presented with hematochezia,abdominal pain,and significant weight loss.Imaging revealed a bulky tumor with invasion of adjacent structures and multiple liver lesions.A diverting ileostomy was performed followed by 36 cycles of pembrolizumab.The patient achieved a clinical and radiologic complete response.One month after completing the treatment,the patient underwent laparoscopic right hemicolectomy.A spontaneous transection of the colon at the original tumor site was unexpectedly identified.Final pathology confirmed pathological complete response(ypT0N0)with fibrosis.The patient recovered well after surgery,and follow-up showed no evidence of recurrence.CONCLUSION Immune checkpoint inhibitors may cause delayed structural damage to bowel tissue even after apparent complete tumor regression.
文摘Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery complications.Despite the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical Cases.This editorial emphasizes the critical need for long-term management and regular surveillance to prevent such complications.By drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.
基金supported by the National Natural Science Foundation of China(Grant Nos.11972027,12472093,and 11772272)the New Interdisciplinary Cultivation Fund of Southwest Jiaotong University(Grant No.2682022JX001)+1 种基金the Frontier Science and Technology Cultivation Project of Southwest Jiaotong University(Grant No.2682022KJ048)the Laboratory of Flexible Electronics Technology at Tsinghua University.
文摘Mechanical snap-through instability of bi-stable structures may find many practical applications such as state switching and energy transforming.Although there exist diverse bi-stable structures capable of snap-through instability,it is still difficult for a structure with high slenderness to undergo the axial snap-through instability with a large stroke.Here,an elastic structure with high slenderness is simply constructed by a finite number of identical,conventional bi-stable units with relatively low slenderness in series connection.For realizing the axial snap-through instability with a large stroke,common scissors mechanisms are further introduced as rigid constraints to guarantee the synchronous snap-through instability of these bi-stable units.The global feature of the large-stroke snap-through instability realized here is robust and even insusceptible to the local out-of-synchronization of individual units.The present design provides a simple and feasible way to achieve the large-stroke snap-through instability of slender structures,which is expected to be particularly useful for state switching and energy transforming in narrow spaces.
基金supported by the National Natural Science Foundation of China(No.42075177)the National Key Research and Development Program of China(No.2017YFC0210003).
文摘Extensive spatiotemporal analyses of long-trend surface ozone in the Yangtze River Delta(YRD)region and itsmeteorology-related and emission-related have not been systematically analyzed.In this study,by using 8-year-long(2015–2022)surface ozone observation data,we attempted to reveal the variation ofmultiple timescale components using the Kolmogorov–Zurbenko filter,and the effects of meteorology and emissions were quantitatively isolated using multiple linear regression with meteorological variables.The results showed that the short-term,seasonal,and long-term components accounted for daily maximum 8-hr average O_(3)(O_(3–8)hr)concentration,46.4%,45.9%,and 1.0%,respectively.The meteorological impacts account for an average of 71.8%of O_(3–8)hr,and the YRD’s eastern and northern sections aremeteorology-sensitive areas.Based on statistical analysis technology with empirical orthogonal function,the contribution of meteorology,local emission,and transport in the long-term component of O_(3–8)hr were 0.21%,0.12%,and 0.6%,respectively.The spatiotemporal analysis indicated that a distinct decreasing spatial pattern could be observed from coastal cities towards the northwest,influenced by the monsoon and synoptic conditions.The central urban agglomeration north and south of the YRD was particularly susceptible to local pollution.Among the cities studied,Shanghai,Anqing,and Xuancheng,located at similar latitudes,were significantly impacted by atmospheric transmission—the contribution of Shanghai,the maximum accounting for 3.6%.
基金support of the National Natural Science Foundation of China(No.52322603)the Science Center for Gas Turbine Project of China(Nos.P2022-B-II-004-001 and P2023-B-II-001-001)+1 种基金the Fundamental Research Funds for the Central Universities,Chinathe Beijing Nova Program of China(Nos.20220484074 and 20230484479).
文摘The utilization of Inlet Guide Vane (IGV) plays a key factor in affecting the instability evolution. Existing literature mainly focuses on the effect of IGV on instability inception that occurs in the rotor region. However, with the emergence of compressor instability starting from the stator region, the mechanism of various instability inceptions that occurs in different blade rows due to the change of IGV angles should be further examined. In this study, experiments were focused on three types of instability inceptions observed previously in a 1.5-stage axial flow compressor. To analyze the conversion of stall evolutions, the compressor rotating speed was set to 17 160 r/min, at which both the blade loading in the stator hub region and rotor tip region were close to the critical value before final compressor stall. Meanwhile, the dynamic test points with high-response were placed to monitor the pressures both at the stator trailing edges and rotor tips. The results indicate that the variation of reaction determines the region where initial instability occurs. Indeed, negative pre-rotation of the inlet guide vane leads to high-reaction, initiating stall disturbance from the rotor region. Positive pre-rotation results in low-reaction, initiating stall disturbance from the stator region. Furthermore, the type of instability evolution is affected by the radial loading distribution under different IGV angles. Specifically, a spike-type inception occurs at the rotor blade tip with a large angle of attack at the rotor inlet (−2°, −4° and −6°). Meanwhile, the critical total pressure ratio at the rotor tip is 1.40 near stall. As the angle of attack decreases, the stator blade loading reaches its critical boundary, with a value of approximately 1.35. At this moment, if the rotor tip maintains high blade loading similar to the stator hub, the partial surge occurs (0° and +2°);otherwise, the hub instability occurs (+4° and +6°).
基金supports of the National Natural Science Foundation of China(Nos.52076129,92360308,52376027)the Shanghai Municipal Education Commission of China(No.2023-02-4)+1 种基金the Fundamental Research Funds for the Central Universities of Chinathe United Innovation Center(UIC)of Aerothermal Technologies for Turbomachinery of China.
文摘Rotating Instability (RI) is a typical unsteady flow phenomenon in compressors and may cause severe aerodynamic noise and even potential nonsynchronous vibration. Most studies of RI are based on the uniform inflow, ignoring the influence of inlet distortions. This study investigates the mechanism of RI in a transonic rotor through full-annulus unsteady simulations, with a particular focus on the effects of boundary layer ingesting distortions. The results show that at the uniform inflow, the RI fluctuations with the broadband hump can be observed over a relatively wide mass flow rate range, and its origin can be attributed to the coupling effect between the tip leakage flow and shear layer instability. At the inlet distortions, the broadband hump only occurs with partial circumferential locations. This kind of flow phenomenon is defined as Partial Rotating Instability (PRI). The PRI only occurs in a narrower mass flow rate range in which the circumferential range of strong shear is sufficiently large and the self-induced unsteady effects are strong enough. Further, this study confirms that the averaged tip leakage flow axial momentum at the onset of RI or PRI is close, so it can be used as the parameter to determine whether RI or PRI occurs.
文摘A hydrodynamic model is used to study Kelvin-Helmholtz(KH)instability of the interface between two particle-laden inviscid fluids moving with two different uniform mean velocities.Explicit eigen-equation is derived to study the effect of suspended particles on the growth rate of KH instability.For dusty gases with negligible volume fraction of heavy particles and small particle-to-fluid mass ratio,the real and imaginary parts of leading-order asymptotic expression derived by the present model for the growth rate are shown to be identical to the earlier results derived by the classical Saffman model established for dusty gases.Beyond the known results,explicit leading-order asymptotic expressions for the effect of suspended particles on the growth rate are derived for several typical cases of basic interest.It is shown that the suspended particles can decrease or increase the growth rate of KH instability depending on the Stokes numbers of the particles and whether the particles are heavier or lighter than the clean fluid.Compared to the mass density of the clean fluid,our results based on leading-order asymptotic solutions show that heavier particles and lighter particles have opposite effects on the growth rate of KH instability,while the effect of neutrally buoyant particles on the growth rate of KH instability is negligible.
基金supported by the Natural Science Foundation of Hunan Province,China(No.2024JJ1012)the Postgraduate Innovative Project of Central South University,China(No.2023ZZTS0459)the National Key Research and Development Program of China(No.2019YFC1803605)。
文摘Slow-release phosphate materials were prepared by activating insoluble phosphate with organic acid to stabilize high concentrations of Cd and Zn in contaminated smelter soil.The results showed that oxalic acid(0.1 mol/L)activated tricalcium phosphate(TO-0.1)provided the most efficient stabilization of Cd and Zn.After 30 d treatment,leaching concentrations of Cd and Zn in soil were decreased from 3.17 and 16.60 mg/L to 0.078 and 0.32 mg/L,respectively.The acid-soluble fractions of Cd and Zn were transformed into reducible,oxidizable,and residual fractions.Notably,As mobility in TO-0.1 treated soils did not increase.In addition,acid rain leaching and 150 d of natural aging revealed that the slow-release phosphate material provided long-term stability for the stabilization of Cd and Zn.This study verifies the potential application of slow-release phosphate materials for the remediation of heavy metal contaminated soil at smelting sites.
文摘Objective: To analyze the clinical manifestations of intraocular lens (IOL) opacity after cataract surgery through case reports, and to explore its pathogenesis and diagnosis and treatment ideas, so as to provide a basis for the early diagnosis and correct treatment of IOL opacity. Methods: The clinical data of one patient diagnosed with IOL opacity and underwent intraocular lens replacement in the Department of Ophthalmology, Affiliated Hospital of Youjiang Medical College for Nationalities in December 2023 were reported. The characteristics of IOL opacity were observed, and the research progress and pathogenesis of IOL opacity were understood by consulting the literature. Results: This patient is the first case of IOL opacity in our hospital. The specific reason is unclear. It is considered to be related to the IOL material. Conclusion: Hydrophilic acrylic IOL is widely used in clinic because of its good histocompatibility. However, due to its hydrophilicity, there are more cases of IOL opacity than other types of IOL. At present, there is no unified conclusion on the etiology and mechanism of IOL opacity. IOL opacity can seriously affect vision and is easily misdiagnosed as a posterior cataract. We should fully disperse the large pupil and carefully observe under the slit lamp. The most effective treatment for this disease is IOL replacement.
基金supported by the National Natural Science Foundation of China(Nos.U19A2044,42105132,42030609,41975037)the National Key Research and Development Programof China(No.2022YFC3700303).
文摘The Yangtze River Delta(YRD)region has witnessed a consistent decrease in NO_(2),CO,and PM_(2.5) from 2016 to 2023.However,ozone has exhibited fluctuating patterns.Quantifying ozone contributions from emissions,both within and outside the YRD,is essential for understanding city-cluster-scale ozone pollution(CCSOP).To address these concerns,a comprehensive approach combining Kolmogorov-Zurbenko filtering,Empirical Orthogonal Function,Absolute Principal Component Score,andMultiple Linear Regression methods(KZ-EOF-APCs-MLR)was employed to quantify the impacts of meteorological factors,local and non-local emission contributions of ozone(LECO and NECO).Emission changes were identified as the predominant factor shaping annual fluctuations in ambient ozone.Notably,during the previous andmiddle stages of the COVID-19 pandemic(from2017 to 2021),emissions reductions led to a marked decrease in YRD ozone levels(-7.01μg/m^(3)),with a pronounced rebound post-pandemic(2022 to 2023)(+8.04μg/m^(3)).Seasonally,the emissioninduced ozone exhibited fluctuating upward trend during autumn and winter,suggesting a transition of ozone pollution towards colder seasons.Spatially,high LECO concentrated in the eastern YRD(EYRD)across spring,autumn,and winter,becoming prominent in the central YRD(CYRD)during summer.During CCSOP,the CYRD exhibited the highest LECO and exceedance frequency(20.82μg/m^(3) and 45.27%).LECO explained a large portion of ozone variability during CCSOP,particularly in the EYRD,while NECO showed less explanatory power but consistently high contributions(148.05±15.52μg/m^(3)).These findings offer valuable insights for a deeper understanding of the evolving patterns of ozone pollution and the issue of CCSOP in the YRD.
基金Supported by the Laoshan Laboratory(No.LSKJ202204005)the International Partnership Program of Chinese Academy of Sciences(No.121311KYSB20190029)+1 种基金the National Natural Science Foundation of China(Nos.U2006206,32371619)the International Partnership Program of Chinese Academy of Sciences(No.133137KYSB20200002)。
文摘To better understand the spatial variations in phytoplankton abundance and community structure and their relationship with environmental parameters in Jiaozhou Bay,Yellow Sea,in Shandong,East China,observations were conducted to estimate abundance of net-phytoplankton and key groups along with environmental parameters in three typical sites in seasonal survey from 2004 to 2016 in the bay.The spatial patterns of phytoplankton abundance differed obviously between the inner and the outer bay.The abundance of total phytoplankton and diatoms increased obviously in the northern part of the bay,while decreased in the southern part and outer bay.An increase in dinoflagellate abundance was obvious in the outer bay.Variations in the dynamics of phytoplankton abundance could be largely explained by the succession of chain-forming diatoms and dinoflagellates.The key chain forming diatom groups Chaetoceros and Thalassiosira increased markedly,especially in winter in the northern part of the bay,while in the southern part and the outer bay,Chaetoceros declined.Besides,the key dinoflagellate groups Ceratium and Noctiluca increased noticeably,resulting in a significant increase in the dinoflagellate/diatom ratio in the outer bay.These variations has a significant correlation with environmental variables of surface seawater temperature,phosphorus,nitrogen,salinity,and N/Si ratio(P<0.05).For the key groups,temperature was the primary driver of dinoflagellate abundance,while the N/P ratio was critical for chain-forming diatoms.The abundance of phytoplankton showed a clear spatial pattern and associated obviously with environmental factors in the marine ecosystems,offering insights into coastal ecosystem management and conservation strategies.
基金supported by the National Research Foundation of Korea(NRF)(RS-2024-00333618 and RS-2023-00240999)a Korea University Grantthe Institute of Biomedical Science&Food Safety,CJ-Korea University Food Safety Hall at Korea University,Republic of Korea。
文摘This study was performed to investigate the changes in microbial communities and metabolites during the long-term fermentation of commercially manufactured anchovy sauce.Samples of commercial anchovy sauce were collected from large-scale fermentation tanks with fermentation periods of up to 7.87 years.The complex bacterial community was simplified to two genera,Tetragenococcus and Halanaerobium,after approximately 0.55 years of fermentation.Although genera,such as Saccharomyces,Cladosporium,Candida,and Aspergillus,were relatively dominant,no clear pattern was identified in fungal community analysis.The longitudinal metabolite profile demonstrated that approximately half(55.8%)of the metabolites present in anchovy sauce were produced within a year of fermentation due to rapid fermentation.Despite the static microbial community,the contents of several metabolites including amino acids and biogenic amines changed continuously during the long-term fermentation of anchovy sauce.This study provides novel insights into the changes in microbiota and metabolites in fish sauce produced without any starter inoculation.
文摘Background:Long-term exposure to light has emerged as a novel risk factor for metabolic diseases.The whitening of brown adipose tissue(BAT)may play an important role in metabolic disorders caused by long-term continuous light exposure.This study aimed to investigate the morphological and functional alterations in BAT under continuous light conditions and to identify traditional Chinese medicine compounds capable of reversing these changes.Methods:A metabolic disorder model was established by subjecting mice to continuous light exposure for 5 weeks.During this period,body weight,food intake,and body fat percentage were monitored.Serum levels of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),and low density lipoprotein cholesterol(LDL-C)were measured to assess lipid metabolism.Histological changes in BAT were examined using H&E staining.The expression of the thermogenic marker uncoupling protein 1(UCP1)in BAT was determined by RT-qPCR and Western blot to evaluate thermogenic function.RNA sequencing(RNA-seq)was employed to identify differentially expressed genes(DEGs)involved in BAT whitening induced by prolonged continuous light exposure.DEGs were analyzed using the connectivity map(CMap)database to identify potential preventive and therapeutic compounds.The therapeutic efficacy of the selected compounds was subsequently evaluated using the above indicators,and key pathways were validated through western blot analysis.Results:After 5 weeks of continuous light exposure,mice exhibited increased body fat percentage and serum levels of TG,impaired mitochondrial function,reduced thermogenic capacity,and whitening of BAT.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)enrichment analyses indicated that BAT whitening was primarily associated with the adenosine 5'-monophosphate-activated protein kinase(AMPK)signaling pathway,fatty acid metabolism,and circadian rhythm.Ten hub genes identified using Cytoscape were mainly related to AMPK signaling and heat shock proteins.In vivo experiments showed that cordycepin significantly attenuated the increase in body fat percentage caused by prolonged light exposure.This effect was mediated by activation of the AMPK/PGC-1α/UCP1 signaling pathway,which restored the multilocular morphology and thermogenic function of BAT.Conclusion:Cordycepin mitigates continuous light-induced BAT whitening and metabolic disturbances by activating the AMPK signaling pathway.
文摘BACKGROUND Gastric cancer is a major global health issue,and the perioperative period critic-ally influences patient outcomes.The different effects of sevoflurane inhalation anesthesia and propofol total intravenous anesthesia on intraoperative stability,postoperative complications,and long-term oncologic outcomes in patients with gastric cancer undergoing radical gastrectomy remain unclear.AIM To compare the effects of sevoflurane inhalation anesthesia and propofol total in-travenous anesthesia on clinical outcomes,including intraoperative indicators,postoperative complications,adverse effects,pain scores,and survival.METHODS This single-center retrospective cohort study included 204 patients who underw-ent radical gastrectomy for gastric cancer from February 2019 to December 2022.Patients were assigned to either the sevoflurane group(n=103)or the propofol group(n=101)based on intraoperative anesthetic regimen.Standardized protoc-ols for anesthesia management,intraoperative monitoring,and postoperative analgesia were applied.Baseline characteristics;intraoperative metrics;adverse events;complications;Visual Analog Scale(VAS)scores at 2,4,6,24,and 48 hours;and survival outcomes were retrospectively collected.Group comparisons were performed usingχ2 for categorical variables,t test for continuous variables,RESULTS Baseline demographic and clinical characteristics were similar between groups.No significant differences were observed in intraoperative indicators or most 30-day postoperative outcomes,including length of stay,emergency department visits,and readmission rates.The propofol group showed elevated mean VAS pain score at 24 hours postoperatively,but no differences were found at other time points.The propofol group also had significantly higher postoperative nausea incidence and transiently higher systolic/diastolic blood pressure and heart rate at the time of incision than the sevoflurane group.No significant differences were seen in overall rates or severity of postoperative complications,intraoperative adverse events,or in overall survival and progression-free survival.CONCLUSION In patients undergoing radical gastrectomy for gastric cancer,sevoflurane and propofol anesthesia demonstrated similar profiles regarding intraoperative safety,postoperative complications,adverse events,postoperative pain,and long-term survival.The selection of anesthesia can be personalized without significantly affecting periop-erative or oncologic outcomes.
文摘Solar radiation data forecasting algorithms are important,especially in developing countries,as vast solar power plants cannot measure reliable and constant solar irradiance.The challenges of solar irradiance prediction may be resolved by machine learning using weather datasets.This study emphasises the daily and monthly global solar radiation data predictions of three locations,Pretoria,Bloemfontein,and Vuwani,at different provinces in South Africa with various solar radiation distributions.The study evaluated five different machine learning models.Forecasting models were established to evaluate global solar radiation,focusing on input data.The selected forecast models are centered on their ability to perform with time series data.These models use five years of data from meteorological parameters,such as global horizontal irradiance(GHI),relative humidity,wind speed and ambient temperature between 1 January 2018 and 31 December 2022.The datasets from these meteorological parameters are utilised for training and testing the employed algorithms,which are examined using five statistical metrics.Moreover,the inconsistency of the solar irradiance time series was equally assessed using the clearness index.The results from this study demonstrate that the R2 value recording 0.866 datasets in Bloemfontein of random forest algorithm presents the highest performance during the training processes for all models studied,while the random tree in Vuwani showed the lowest performance of R2 of 0.210 with other algorithms in testing processes.Additionally,the maximum solar radiation was found in December for both Pretoria and Bloemfontein,recorded as 5.347 and 5.844 kWh/m2/day,respectively,while it was 4.692 kWh/m2/day at Vuwani in January.Similarly,the average clearness index of 0.605,0.657 and 0.533 are obtained at Pretoria,Bloemfontein,and Vuwani,respectively.Among the three sites under study,the solar radiation and clearness index are higher in Bloemfontein.Therefore,the proposed algorithms could be used conveniently for short-and long-term solar power plants in South Africa.
