From viewpoint of nonlinear dynamics, the model reduction and its influence on the long-term behaviours of a class of nonlinear dissipative autonomous dynamical system with higher dimension are investigated theoretica...From viewpoint of nonlinear dynamics, the model reduction and its influence on the long-term behaviours of a class of nonlinear dissipative autonomous dynamical system with higher dimension are investigated theoretically under some assumptions. The system is analyzed in the state space with an introduction of a distance definition which can be used to describe the distance between the full system and the reduced system, and the solution of the full system is then projected onto the complete space spanned by the eigenvectors of the linear operator of the governing equations. As a result, the influence of mode series truncation on the long-term behaviours and the error estimate are derived, showing that the error is dependent on the first products of frequencies and damping ratios in the subspace spanned by the eigenvectors with higher modal damping. Furthermore, the fundamental understanding for the topological change of the solution due to the application of different model reduction is interpreted in a mathematically precise way, using the qualitative theory of nonlinear dynamics.展开更多
Investigations into the long-term creep behavior of Beishan granite in uniaxial compression were conducted.Four levels of axial stress(60,70,87,and 95 MPa)were applied to rock specimens.Contrasting with earlier resear...Investigations into the long-term creep behavior of Beishan granite in uniaxial compression were conducted.Four levels of axial stress(60,70,87,and 95 MPa)were applied to rock specimens.Contrasting with earlier research,the long-term creep data in this work present a substantial advancement in the time dimension.Except for the sample subjected to 60 MPa axial loading,which did not fail after a loading duration of 1650 d,the specimens under the other three stresses all failed after sustained constant loading durations of 1204,1023,and 839 d,respectively.A lower envelope of driving stress-ratio for crystalline rocks was obtained,tending towards approximately 0.45 over an infinite time scale.According to the experimental results,as axial stress increases,both the axial strain accumulated in the transient creep process and the strain rate associated with steady-state creep deformation increase exponentially;however,the share of steady-state creep strain remains nearly constant at about82.53%.A novel damage-based creep model was put forward.It provides an enhanced depiction of the comprehensive creep process in rocks,notably improving the accuracy in forecasting the accelerated creep phase,which significantly impacts the long-term stability of engineering structures.展开更多
Globally,mealtimes provide key insights into cultural and social values and practices.We examine mealtime environments and eating practices in two different African settings using quantitative observational and questi...Globally,mealtimes provide key insights into cultural and social values and practices.We examine mealtime environments and eating practices in two different African settings using quantitative observational and questionnaire data.Participating families(N=80)were recruited from two rural locations in Zambia and Kenya.Results following descriptive analysis showed that meals are typically taken as a family in a sociable context,providing opportunities to nurture children’s positive behaviours.In both communities,mothers(71.25%)were most likely to be present and typically prepared meals and provided the food.We observed a few distractions being used during mealtimes,and children finished their food with little to no conflict.Plate sharing varied across the two sites and was more common in Zambia,where we also observed more traditional practices such as eating with hands(as opposed to cutlery)and sitting on mats on the ground(as opposed to seated on chairs or sofas).Overall,our findings suggest more similarities in the cultural and social values across the two African contexts despite slight differences in mealtime practices.In particular,positive mealtime behaviours(little food refusal,lack of conflict)were common across all contexts,regardless of the extent to which traditional practices(such as plate-sharing and sitting on the floor)were used.Findings align with Family Systems theory,which states that the family is understood best by conceptualizing it as a complex,dynamic,and changing collection of parts,subsystems,and family members.展开更多
While oceanic and coastal acidification has gained increased attention,long-term pH trends and their drivers in large freshwater systems remain poorly understood.The Laurentian Great Lakes are the world’s largest fre...While oceanic and coastal acidification has gained increased attention,long-term pH trends and their drivers in large freshwater systems remain poorly understood.The Laurentian Great Lakes are the world’s largest freshwater system,and in many ways resemble marine ecosystems.However,unlike the open ocean and coastal waters where pH has declined due to rising atmospheric CO_(2),no significant pH trends have been observed in the Laurentian Great Lakes,despite significant ecosystem changes driven partly by the invasion of dreissenid mussels.This study examined 41 years of field observations from Lake Michigan to investigate the long-term carbonate chemistry dynamics.Observational results revealed substantial declines in both total alkalinity(TA)and dissolved inorganic carbon(DIC)over the four decades.Mussel shell calcification emerged as the primary mechanism behind these declines,accounting for 97%and 47%of the observed changes in TA and DIC,respectively,lowering water column pH by 0.24 units.Elevated carbon accumulation in soft mussel tissues,coupled with long-term changes in the air-water pCO_(2)gradient during summer,significantly contributed to long-term DIC variations,explaining 18%and 28%of the lake-wide DIC loss.These two mechanisms also resulted in an overall pH increase of 0.09 and 0.12 units,largely offsetting the calcification-driven pH decrease.These findings bridge a gap in acidification research for large freshwater systems and provide valuable insights for comprehensive lake-wide management strategies.展开更多
Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a referen...Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a reference for the selection of clinical treatment plans.Methods:A retrospective analysis was conducted on the clinical data of 68 patients with early-stage breast cancer admitted from January 2022 to December 2025.Based on the surgical approach,patients were divided into an observation group(breast-conserving surgery+sentinel lymph node biopsy)and a control group(other surgical methods such as modified radical mastectomy/total mastectomy).Clinical and pathological characteristics,incidence of postoperative complications,follow-up prognosis,and satisfaction with cosmetic outcomes were compared between the two groups.Results:Among the 68 patients,41 were in the observation group and 27 in the control group.The average age of patients in the observation group was(54.32±8.15)years,while that in the control group was(62.45±9.76)years.The average tumor size in the observation group was(1.86±0.72)cm,compared to(3.21±1.45)cm in the control group.The incidence of postoperative complications in the observation group was 9.76%,significantly lower than that in the control group at 33.33%(P<0.05).The 6-month disease-free survival rate was 95.12%in the observation group and 88.89%in the control group,with no statistically significant difference between the two groups(P>0.05).The excellent and good rate of cosmetic outcomes in the observation group was 87.80%,significantly higher than that in the control group at 29.63%(P<0.05).Conclusion:Breast-conserving surgery combined with sentinel lymph node biopsy for early-stage breast cancer can achieve long-term prognostic outcomes comparable to those of traditional radical surgery,with the advantages of fewer postoperative complications and superior cosmetic results.This approach is worthy of clinical promotion and application,particularly for early-stage breast cancer patients who have a demand for preserving breast morphology.展开更多
AIM:To investigate the long-term outcomes in acute primary angle closure(APAC)patients treated with lens extraction(LE)surgery and to identify risk factors for glaucomatous optic neuropathy(GON).METHODS:In this longit...AIM:To investigate the long-term outcomes in acute primary angle closure(APAC)patients treated with lens extraction(LE)surgery and to identify risk factors for glaucomatous optic neuropathy(GON).METHODS:In this longitudinal observational study,detailed medical histories of APAC patients and comprehensive ophthalmic examinations at final followup were collected.Logistic regression analysis was performed to identify predictors of blindness.Univariate and multivariate linear regression analyses were conducted to determine risk factors associated with visual outcomes.RESULTS:This study included 39 affected eyes of 31 subjects(26 females)with an average age of 74.1±8.0y.At 6.7±4.2y after APAC attack,2(5.7%)eyes had bestcorrected visual acuity(VA)worse than 3/60.Advanced glaucomatous visual field loss was observed in 15(39.5%)affected eyes and 5(25.0%)fellow eyes.Nine affected eyes(23.7%)had GON,and 11(28.9%)were blind.Six(15.4%)affected eyes and 2(9.1%)fellow eyes had suspicious progression.A significantly higher blindness rate in factory workers compared to office workers.Logistic regression identified that worse VA at attack(OR 10.568,95%CI 1.288-86.695;P=0.028)and worse early postoperative VA(OR 13.214,95%CI 1.157-150.881;P=0.038)were risk factors for blindness.Multivariate regression showed that longer duration of elevated intraocular pressure(P=0.004)and worse early postoperative VA(P=0.009)were associated with worse visual outcomes.CONCLUSION:Despite LE surgery,some APAC patients experience continued visual function deterioration.Lifelong monitoring is necessary.Target pressure and progression rates should be re-evaluated during follow-up.展开更多
Taking the rural low-income population of Zhejiang Province as its subject, this paper examines how to build a sustainable income-growth mechanism and identify feasible implementation paths within the context of the c...Taking the rural low-income population of Zhejiang Province as its subject, this paper examines how to build a sustainable income-growth mechanism and identify feasible implementation paths within the context of the common prosperity strategy. The research identifies key obstacles to income expansion, including an undiversified industrial structure, insufficient human capital, and a lack of robust social protection. These call for systemic solutions featuring institutional innovation, resource consolidation, and capability enhancement. Building on Zhejiang's experience as a common prosperity demonstration zone, the article constructs an integrated framework centered on four pillars: industrial empowerment, education upgrading, social security reinforcement, and digital coordination. It further offers concrete policy proposals involving the cultivation of localized industries, vocational skill training, enhanced safety nets, and the adoption of digital tools. The study thus offers both theoretical insights and practical paradigms for tackling the challenge of raising incomes in low-income rural areas.展开更多
Long-term manure application has the potential to alleviate soil acidification, and increase carbon sequestration and nutrient availability, thus improving cropland fertility. However, the mechanisms behind greenhouse...Long-term manure application has the potential to alleviate soil acidification, and increase carbon sequestration and nutrient availability, thus improving cropland fertility. However, the mechanisms behind greenhouse gas N_(2)O emissions from acidic soil mediated by long-term manure application remain poorly understood. Herein, we investigated N_(2)O emission and its linkage with gross N mineralization and nitrification rates, as well as nitrifying and denitrifying microbes in an acidic upland soil subjected to 36-year fertilization treatments, including an unfertilized control(CK), inorganic fertilizer(F), 2× rate of inorganic fertilizer(2F), manure(M), and the combination of inorganic fertilizer and manure(FM) treatments. Compared to the CK treatment(1.34 μg N kg^(-1) d^(-1)), fertilization strongly increased N_(2)O emissions by 34-fold on average, with more pronounced increases in the manure-amendment(10.6-169 μg N kg^(-1) d^(-1)) than those in the inorganic fertilizer treatments(3.26-5.51 μg N kg^(-1) d^(-1)). The manure amendment-stimulated N_(2)O emissions were highly associated with increased soil pH, mean weight diameter of soil aggregates, substrate availability(e.g., particulate organic carbon, NO_(3)^(-)and available phosphorus), gross N mineralization rates, denitrifier abundances and the(nirK+nirS)/nosZ ratio. These findings suggest that the increased N_(2)O emissions primarily resulted from alleviated acidification, increased substrate availability and improved soil structure, thus enhancing microbial N mineralization and favoring N_(2)O^(-)producing denitrifiers over N_(2)O consumers. Moreover, ammonia-oxidizing bacteria(AOB) rather than ammonia-oxidizing archaea(AOA) positively correlated with soil NO_(3)^(-)concentration and N_(2)O emissions, indicating that nitrification indirectly contributed to N_(2)O production by supplying NO_(3)^(-)for denitrification. Collectively, manure amendment potentially stimulates N_(2)O emissions, primarily resulting from alleviated soil acidification and increased substrate availability, thus enhancing N mineralization and denitrifier-mediated N_(2)O production. Our findings suggest that consideration should be given to the greenhouse gas budgets of agricultural ecosystems when applying manure for managing the pH and fertility of acidic soils.展开更多
Waterborne acrylic coatings are widely utilized due to their cost-effectiveness,high transparency,strong resistance to weather and chemicals,impressive mechanical properties,and excellent adhesion to various substrate...Waterborne acrylic coatings are widely utilized due to their cost-effectiveness,high transparency,strong resistance to weather and chemicals,impressive mechanical properties,and excellent adhesion to various substrates.In these coatings,a reactive emulsifier containing phosphate groups can be integrated into the molecular chain during polymerization,which enhances the coating's compactness and corrosion resistance.This work focuses on the synthesis of styrene-butyl acrylate(St-BA)latex and methyl methacrylate-butyl acrylate(MMA-BA)latex using the reactive phosphate emulsifier ANPEO_(10)-P_(1) through seed emulsion polymerization,achieving a conversion rate of approximately 99%and a solid content close to 50%.The resulting coatings from St-BA and MMA-BA latexes demonstrated long-term corrosion protection for carbon steel and aluminum alloy due to in-situ phosphatization,effectively preventing flash rust.Notably,the MMA-BA coating exhibited remarkable durability,enduring immersion for up to 1224 h(51 d)on Q 235 carbon steel before reaching the failure threshold(|Z|0.01 Hz£106Ω·cm^(2))on Q 235 carbon steel.On 5052 aluminum alloy,the St-BA coating maintained|Z|0.01 Hz>10^(8)Ω·cm^(2) for 480 h(20 d).Furthermore,the corrosion resistance of St-BA and MMA BA coatings on Q 235 steel sheet and 5052 aluminum alloy surpassed that of commercially available MMA-BA and St BA coatings after immersion in a 3.5 wt%NaCl aqueous solution.This work also delves into the anticorrosion mechanism of MMA-BA and St-BA coatings.展开更多
Creep is an important characteristic of bamboo and wood materials under long-term loading.This paper aims to study the long-term bending beha-viour of prestressed glulam bamboo-wood beam(GBWB).For this,14 pre-stressed...Creep is an important characteristic of bamboo and wood materials under long-term loading.This paper aims to study the long-term bending beha-viour of prestressed glulam bamboo-wood beam(GBWB).For this,14 pre-stressed GBWBs were selected and subjected to a long-term loading test for 60 days.Then,a comparative analysis was performed for the effects of pre-tension values,the number of pre-stressed wires,and long-term load on the stress variation of the steel wire and the long-term deflection of the beam midspan.The test results showed that with the number of prestressed wires increasing,the total stress of the steel wire in the beam midspan and the ratio of the long-term deflec-tion to the total deflection decreases decreased,but when the number of steel wires exceeded 4,the total stress and long-term deflection was less infuenced;with the pre-tension value increasing,the ratio of the total stress of the steel wire in the beam midspan and the ratio of the long-temm deflection to the total deflec-tion also decreased,but when the prestress force was greater than 3.975 kN,the:total stress and long-term deflection were less affected;with the other parameters unchanged,when the value of the long-term load increased,the total stress of the steel wire decreased,and the long-temm deflection of the beam midspan increased,which shall be more significant with the long-term load greater than 30%of the standard ultimate bearing capacity.After the test,the experimental data were fitted,and the creep coefficient was given.Finally,the long-term stiffness calcula-tion fommula of the pre-stressed GBWB based on creep effect was proposed.The research findings have certain theoretical significance and engineering value.展开更多
Polyurethane-fluorinated polysiloxane(PU-^(F)PDMS)with high-strength,high-bonding and low surface en-ergy is synthesized as the matrix,and the PU-^(F)PDMS/MCs/Ag marine anti-fouling coating on the sur-face of imitatio...Polyurethane-fluorinated polysiloxane(PU-^(F)PDMS)with high-strength,high-bonding and low surface en-ergy is synthesized as the matrix,and the PU-^(F)PDMS/MCs/Ag marine anti-fouling coating on the sur-face of imitation crab shells is constructed by assembling butenolide@1,1-stilbene-modified hydrolyzed polyglycidyl methacrylate/graphene oxide microcapsules(Bu@PGMAm/GO MCs)with compact multi-shell structure and Ag nanoparticles(AgNPs)step by step on the PU-^(F)PDMS matrix.The PU-^(F)PDMS/MCs/Ag bionic anti-fouling coatings achieve long-term and stable anti-fouling effect under the combination of robust low-surface-energy PU-^(F)PDMS matrix,steady-state sustained release of butenolide encapsulated by the compact multi-shell,bionic surface formed by the microcapsules and AgNPs,and the release of Ag^(+).The shear strength,tensile strength,and elongation at break of the PU-^(F)PDMS/MCs/Ag are 3.53 MPa,6.7 MPa,and 192.83%,respectively.Its static contact angle and sliding angle are 161.8°and 3.6°,respectively.The antibacterial rate of PU-^(F)PDMS/MCs/Ag against Escherichia coli,Staphylococcus aureus,and Candida albicans can reach 100%.Compared with glass blank,PU,PU-^(F)PDMS,PU-^(F)PDMS/Ag,and PU-^(F)PDMS/MCs,both the adhesion number and coverage percentage of chlorella adhere to PU-^(F)PDMS/MCs/Ag are the minimum values,which are 600 cell mm^(-2) and 1.53%,respectively.After 6 months of marine field test,the primer blank,PU,PU-^(F)PDMS all show different degrees of attachment by shellfish,spirorbis,al-gae and other biofouling,while the PU-^(F)PDMS/MCs/Ag coating is still not covered with biofouling,while the PU-^(F)PDMS/MCs/Ag coatings still exhibit little attachment of marine fouling.The PU-^(F)PDMS/MCs/Ag bionic anti-fouling coatings are expected to be widely used in the fields of anti-fouling,anti-icing,anti-fogging,drag reduction,self-cleaning,and antibacterial.展开更多
To enhance the anti-corrosion performance of TC4 alloy across a wide temperature range for modern aircrafts operating in increasingly harsh environments, the (TiB+TiC) hybrid reinforced TC4 composites were prepared by...To enhance the anti-corrosion performance of TC4 alloy across a wide temperature range for modern aircrafts operating in increasingly harsh environments, the (TiB+TiC) hybrid reinforced TC4 composites were prepared by laser melting deposition (LMD) via the in-situ reaction between B_(4)C reinforcement and molten TC4 alloy. The effect of B_(4)C content (0, 0.5, 1.5, wt%) on the microstructure and room/high-temperature corrosion behaviour of the composites was investigated. Microstructural analysis revealed that the microstructure of the composites was significantly influenced by the B_(4)C content. The composite containing 0.5 wt% B_(4)C exhibited an optimal microstructure characterized by refined grains, equiaxed α-Ti transformed from lath-shaped α-Ti, well-distributed (TiB+TiC) phases with a proper amount and reduced pore/dislocation defects. This composite also demonstrated the best corrosion resistance at both room temperature (25 ℃) and high temperature (800 ℃), which was primarily attributed to its comprehensive advantages including a favorable microstructure, a uniform dispersion of thermally stable (TiB+TiC) phases and a stable passivation film.展开更多
Superhydrophobic surface is a promising strategy for antibacterial and corrosion protection.However,the use of harmful fluorine-containing materials,poor mechano-chemical stability,the addition of fungicides and poor ...Superhydrophobic surface is a promising strategy for antibacterial and corrosion protection.However,the use of harmful fluorine-containing materials,poor mechano-chemical stability,the addition of fungicides and poor corrosion resistance often limit its practical application.In this paper,a high-robustness pho-tothermal self-healing superhydrophobic coating is prepared by simply spraying a mixture of hydropho-bically modified epoxy resin and two kinds of modified nanofillers(carbon nanotubes and SiO2)for long-term anticorrosion and antibacterial applications.Multi-scale network and lubrication structures formed by cross-linking of modified carbon nanotubes and repeatable roughness endow coating with high ro-bustness,so that the coating maintains superhydrophobicity even after 100 Taber abrasion cycles,20 m sandpaper abrasion and 100 tape peeling cycles.The synergistic effect of antibacterial adhesion and pho-tothermal bactericidal activity endows coating with excellent antibacterial efficiency,which against Es-cherichia coli(E.coli)and Staphylococcus aureus(S.aureus)separately reaches 99.6% and 99.8%.Moreover,the influence of modified epoxy resin,superhydrophobicity,organic coating and coating thicknesses on the anticorrosion of magnesium(Mg)alloy is systematically studied and analyzed.More importantly,the prepared coating still exhibits excellent self-cleaning,anticorrosion and antibacterial abilities after 20 m abrasion.Furthermore,the coating exhibits excellent adhesion(level 4B),chemical stability,UV radiation resistance,high-low temperature alternation resistance,stable heat production capacity and photother-mal self-healing ability.All these excellent performances can promote its application in a wider range of fields.展开更多
Objective:Triple-negative breast cancer(TNBC)is a highly aggressive subtype that lacks targeted therapies,leading to a poorer prognosis.However,some patients achieve long-term recurrence-free survival(RFS),offering va...Objective:Triple-negative breast cancer(TNBC)is a highly aggressive subtype that lacks targeted therapies,leading to a poorer prognosis.However,some patients achieve long-term recurrence-free survival(RFS),offering valuable insights into tumor biology and potential treatment strategies.Methods:We conducted a comprehensive multi-omics analysis of 132 patients with American Joint Committee on Cancer(AJCC)stage III TNBC,comprising 36 long-term survivors(RFS≥8 years),62 moderate-term survivors(RFS:3-8 years),and 34 short-term survivors(RFS<3 years).Analyses investigated clinicopathological factors,whole-exome sequencing,germline mutations,copy number alterations(CNAs),RNA sequences,and metabolomic profiles.Results:Long-term survivors exhibited fewer metastatic regional lymph nodes,along with tumors showing reduced stromal fibrosis and lower Ki67 index.Molecularly,these tumors exhibited multiple alterations in genes related to homologous recombination repair,with higher frequencies of germline mutations and somatic CNAs.Additionally,tumors from long-term survivors demonstrated significant downregulation of the RTK-RAS signaling pathway.Metabolomic profiling revealed decreased levels of lipids and carbohydrate,particularly those involved in glycerophospholipid,fructose,and mannose metabolism,in long-term survival group.Multivariate Cox analysis identified fibrosis[hazard ratio(HR):12.70,95%confidence interval(95%CI):2.19-73.54,P=0.005]and RAC1copy number loss/deletion(HR:0.22,95%CI:0.06-0.83,P=0.026)as independent predictors of RFS.Higher fructose/mannose metabolism was associated with worse overall survival(HR:1.30,95%CI:1.01-1.68,P=0.045).Our findings emphasize the association between biological determinants and prolonged survival in patients with TNBC.Conclusions:Our study systematically identified the key molecular and metabolic features associated with prolonged survival in AJCC stage III TNBC,suggesting potential therapeutic targets to improve patient outcomes.展开更多
Road traffic flow forecasting provides critical information for the operational management of road mobility challenges, and models are used to generate the forecast. This paper uses a random process to present a novel...Road traffic flow forecasting provides critical information for the operational management of road mobility challenges, and models are used to generate the forecast. This paper uses a random process to present a novel traffic modelling framework for aggregate traffic on urban roads. The main idea is that road traffic flow is random, even for the recurrent flow, such as rush hour traffic, which is predisposed to congestion. Therefore, the structure of the aggregate traffic flow model for urban roads should correlate well with the essential variables of the observed random dynamics of the traffic flow phenomena. The novelty of this paper is the developed framework, based on the Poisson process, the kinematics of urban road traffic flow, and the intermediate modelling approach, which were combined to formulate the model. Empirical data from an urban road in Ghana was used to explore the model’s fidelity. The results show that the distribution from the model correlates well with that of the empirical traffic, providing a strong validation of the new framework and instilling confidence in its potential for significantly improved forecasts and, hence, a more hopeful outlook for real-world traffic management.展开更多
Background:Mitochondrial dysfunction plays a critical role in the pathogenesis of Alzheimer’s disease(AD).Resveratrol is a promising compound for the treatment of various neurodegenerative diseases,including AD.Aims:...Background:Mitochondrial dysfunction plays a critical role in the pathogenesis of Alzheimer’s disease(AD).Resveratrol is a promising compound for the treatment of various neurodegenerative diseases,including AD.Aims:To investigate mitochondrial damage and the effects of resveratrol on inflammation,cognitive function,and mitochondrial quality control in APP/PS1 mice.Methods:Comparative analysis of mitochondrial DNA(mtDNA)damage was conducted between 10-month-old APP/PS1 mice and age-matched C57BL/6 mice.Assessments included measurement of amyloid-βlevels,inflammatory markers,swimming distance in the Morris water maze,and gut microbiome composition.Resveratrol’s effects on cytokine expression,mtDNA levels in plasma,and activation of Nuclear factor erythroid 2-related factor 2/Antioxidant response element(Nrf2/ARE)and phosphoinositide 3-kinase/protein kinase B(also known as Akt)/mechanistic target of rapamycin complex 1(PI3K/Akt/mTORC1)signaling pathways were also evaluated.Results:APP/PS1 mice exhibited significantly increased mtDNA damage in the prefrontal cortex,midbrain,and cerebellum,alongside higher amyloid-βlevels and inflammatory markers.Resveratrol treatment led to reduced expression of pro-inflammatory cytokines,a decrease in Proteobacteria levels,and lower cell-free mtDNA in plasma.Partial improvement in long-term spatial memory was observed in APP/PS1 mice following resveratrol treatment,likely due to its anti-inflammatory properties.Activation of the Nrf2/ARE signaling pathway and markers of PI3K/Akt/mTORC1 axis activation were noted,with the latter regulating long-term potentiation.Conclusion:Resveratrol demonstrates potential in mitigating inflammation and improving mitochondrial quality control in APP/PS1 mice,but it does not reduce amyloid-βlevels,highlighting the complexity of AD pathology and the need for further research.展开更多
Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery complications.Despite the effectiveness of initial treatments,such as intravenous immunoglobulin,KD pat...Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery complications.Despite the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical Cases.This editorial emphasizes the critical need for long-term management and regular surveillance to prevent such complications.By drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.展开更多
The functionally graded materials(FGMs)are obtained by various processes.Although a few FGMs are obtained naturally,such as oyster,pearl,and bamboo,additive manufacturing(AM),known as 3D printing,is a net-shaped manuf...The functionally graded materials(FGMs)are obtained by various processes.Although a few FGMs are obtained naturally,such as oyster,pearl,and bamboo,additive manufacturing(AM),known as 3D printing,is a net-shaped manufacturing process employed to manufacture complex 3D objects without tools,molds,assembly,and joining.Currently,commercial AM techniques mostly use homogeneous composition with simplified geometric descriptions,employing a single material across the entire component to achieve functional graded additive manufacturing(FGAM),in contrast to multi-material FGAM with heterogeneous structures.FGMs are widely used in various fields due to their mechanical property advantages.Because FGM plays a significant role in the industrial production,the characteristics and mechanical behaviour of FGMs prepared by AM were reviewed.In this review,the research on FGMs and AM over the past 30 years was reviewed,suggesting that future researchers should focus on the application of artificial intelligence and machine learning technologies in industry to optimize the process parameters of different gradient systems.展开更多
Aqueous sodium-ion batteries(ASIBs) offer significant advantages for energy storage on a large scale,attributed to their economical cost,secure operatio n,and eco-friend ly natu re.Among the leading cathode materials ...Aqueous sodium-ion batteries(ASIBs) offer significant advantages for energy storage on a large scale,attributed to their economical cost,secure operatio n,and eco-friend ly natu re.Among the leading cathode materials for ASIBs,Na_(3)V_(2)(PO_(4))_(3)(NVP) exhibits excellent structural stability and a high Na+diffusion coefficient,making it a promising option.However,the high solubility of vanadium-based materials in aqueous electrolytes engenders suboptimal cycling stability for Na_(3)V_(2)(PO_(4))_(3),constraining its application in ASIBs.Herein,the Cr-substituted Na_(3)V_(1.3)Cr_(0.7)(PO_(4))3@C(NV_(1.3)Cr_(0.7)P) cathode material was synthesized via a simple sol-gel method.It is found that Cr substitution reduces the cell parameters of NV_(1.3)Cr_(0.7)P,effectively reinforcing the crystal structure.Furthermore,NV_(1.3)Cr_(0.7)P alters the Na^(+)insertion/extraction mechanism,transforming the typical two-phase reaction between Na_(1)V_(2)(PO_(4))_(3)and Na_(3)V_(2)(PO_(4))3into continuous solid-solution reactions with stable intermediates.The Cr substitution diminishes the sodium-ion diffusion energy barrier in NV_(1.3)Cr_(0.7)P,leading to smoother Na+insertion and extraction processes.Consequently,NV_(1.3)Cr_(0.7)P exhibits impressive cycling stability,retaining 74.8% of its capacity after 5,000 cycles at a current density of 5 A g^(-1),along with an outstanding rate performance of 79,2% at 10 A g^(-1).This work elucidates the stable Na^(+)insertion/extraction processes in Cr-substituted NV_(1.3)Cr_(0.7)P,offering insights into the application of vanadium-based materials in aqueous sodium-ion batteries.展开更多
Extensive spatiotemporal analyses of long-trend surface ozone in the Yangtze River Delta(YRD)region and itsmeteorology-related and emission-related have not been systematically analyzed.In this study,by using 8-year-l...Extensive spatiotemporal analyses of long-trend surface ozone in the Yangtze River Delta(YRD)region and itsmeteorology-related and emission-related have not been systematically analyzed.In this study,by using 8-year-long(2015–2022)surface ozone observation data,we attempted to reveal the variation ofmultiple timescale components using the Kolmogorov–Zurbenko filter,and the effects of meteorology and emissions were quantitatively isolated using multiple linear regression with meteorological variables.The results showed that the short-term,seasonal,and long-term components accounted for daily maximum 8-hr average O_(3)(O_(3–8)hr)concentration,46.4%,45.9%,and 1.0%,respectively.The meteorological impacts account for an average of 71.8%of O_(3–8)hr,and the YRD’s eastern and northern sections aremeteorology-sensitive areas.Based on statistical analysis technology with empirical orthogonal function,the contribution of meteorology,local emission,and transport in the long-term component of O_(3–8)hr were 0.21%,0.12%,and 0.6%,respectively.The spatiotemporal analysis indicated that a distinct decreasing spatial pattern could be observed from coastal cities towards the northwest,influenced by the monsoon and synoptic conditions.The central urban agglomeration north and south of the YRD was particularly susceptible to local pollution.Among the cities studied,Shanghai,Anqing,and Xuancheng,located at similar latitudes,were significantly impacted by atmospheric transmission—the contribution of Shanghai,the maximum accounting for 3.6%.展开更多
文摘From viewpoint of nonlinear dynamics, the model reduction and its influence on the long-term behaviours of a class of nonlinear dissipative autonomous dynamical system with higher dimension are investigated theoretically under some assumptions. The system is analyzed in the state space with an introduction of a distance definition which can be used to describe the distance between the full system and the reduced system, and the solution of the full system is then projected onto the complete space spanned by the eigenvectors of the linear operator of the governing equations. As a result, the influence of mode series truncation on the long-term behaviours and the error estimate are derived, showing that the error is dependent on the first products of frequencies and damping ratios in the subspace spanned by the eigenvectors with higher modal damping. Furthermore, the fundamental understanding for the topological change of the solution due to the application of different model reduction is interpreted in a mathematically precise way, using the qualitative theory of nonlinear dynamics.
基金financially supported by the China Atomic Energy Authority(CAEA)through the Geological Disposal Programthe National Natural Science Foundation of China(No.42307258)the China National Nuclear Corporation Fundamental Research Project(No.CNNC-JCYJ-202307)。
文摘Investigations into the long-term creep behavior of Beishan granite in uniaxial compression were conducted.Four levels of axial stress(60,70,87,and 95 MPa)were applied to rock specimens.Contrasting with earlier research,the long-term creep data in this work present a substantial advancement in the time dimension.Except for the sample subjected to 60 MPa axial loading,which did not fail after a loading duration of 1650 d,the specimens under the other three stresses all failed after sustained constant loading durations of 1204,1023,and 839 d,respectively.A lower envelope of driving stress-ratio for crystalline rocks was obtained,tending towards approximately 0.45 over an infinite time scale.According to the experimental results,as axial stress increases,both the axial strain accumulated in the transient creep process and the strain rate associated with steady-state creep deformation increase exponentially;however,the share of steady-state creep strain remains nearly constant at about82.53%.A novel damage-based creep model was put forward.It provides an enhanced depiction of the comprehensive creep process in rocks,notably improving the accuracy in forecasting the accelerated creep phase,which significantly impacts the long-term stability of engineering structures.
基金funded by UKRI Global Challenges Research Fund through the Economic and Social Research Council(grant reference:ES/T004959/1)with additional partial support from the National Research Foundation of South Africa(grant CSUR230503101533)。
文摘Globally,mealtimes provide key insights into cultural and social values and practices.We examine mealtime environments and eating practices in two different African settings using quantitative observational and questionnaire data.Participating families(N=80)were recruited from two rural locations in Zambia and Kenya.Results following descriptive analysis showed that meals are typically taken as a family in a sociable context,providing opportunities to nurture children’s positive behaviours.In both communities,mothers(71.25%)were most likely to be present and typically prepared meals and provided the food.We observed a few distractions being used during mealtimes,and children finished their food with little to no conflict.Plate sharing varied across the two sites and was more common in Zambia,where we also observed more traditional practices such as eating with hands(as opposed to cutlery)and sitting on mats on the ground(as opposed to seated on chairs or sofas).Overall,our findings suggest more similarities in the cultural and social values across the two African contexts despite slight differences in mealtime practices.In particular,positive mealtime behaviours(little food refusal,lack of conflict)were common across all contexts,regardless of the extent to which traditional practices(such as plate-sharing and sitting on the floor)were used.Findings align with Family Systems theory,which states that the family is understood best by conceptualizing it as a complex,dynamic,and changing collection of parts,subsystems,and family members.
基金Supported by the National Natural Science Foundation of China(No.43277051)the Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education(No.B230203006).
文摘While oceanic and coastal acidification has gained increased attention,long-term pH trends and their drivers in large freshwater systems remain poorly understood.The Laurentian Great Lakes are the world’s largest freshwater system,and in many ways resemble marine ecosystems.However,unlike the open ocean and coastal waters where pH has declined due to rising atmospheric CO_(2),no significant pH trends have been observed in the Laurentian Great Lakes,despite significant ecosystem changes driven partly by the invasion of dreissenid mussels.This study examined 41 years of field observations from Lake Michigan to investigate the long-term carbonate chemistry dynamics.Observational results revealed substantial declines in both total alkalinity(TA)and dissolved inorganic carbon(DIC)over the four decades.Mussel shell calcification emerged as the primary mechanism behind these declines,accounting for 97%and 47%of the observed changes in TA and DIC,respectively,lowering water column pH by 0.24 units.Elevated carbon accumulation in soft mussel tissues,coupled with long-term changes in the air-water pCO_(2)gradient during summer,significantly contributed to long-term DIC variations,explaining 18%and 28%of the lake-wide DIC loss.These two mechanisms also resulted in an overall pH increase of 0.09 and 0.12 units,largely offsetting the calcification-driven pH decrease.These findings bridge a gap in acidification research for large freshwater systems and provide valuable insights for comprehensive lake-wide management strategies.
文摘Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a reference for the selection of clinical treatment plans.Methods:A retrospective analysis was conducted on the clinical data of 68 patients with early-stage breast cancer admitted from January 2022 to December 2025.Based on the surgical approach,patients were divided into an observation group(breast-conserving surgery+sentinel lymph node biopsy)and a control group(other surgical methods such as modified radical mastectomy/total mastectomy).Clinical and pathological characteristics,incidence of postoperative complications,follow-up prognosis,and satisfaction with cosmetic outcomes were compared between the two groups.Results:Among the 68 patients,41 were in the observation group and 27 in the control group.The average age of patients in the observation group was(54.32±8.15)years,while that in the control group was(62.45±9.76)years.The average tumor size in the observation group was(1.86±0.72)cm,compared to(3.21±1.45)cm in the control group.The incidence of postoperative complications in the observation group was 9.76%,significantly lower than that in the control group at 33.33%(P<0.05).The 6-month disease-free survival rate was 95.12%in the observation group and 88.89%in the control group,with no statistically significant difference between the two groups(P>0.05).The excellent and good rate of cosmetic outcomes in the observation group was 87.80%,significantly higher than that in the control group at 29.63%(P<0.05).Conclusion:Breast-conserving surgery combined with sentinel lymph node biopsy for early-stage breast cancer can achieve long-term prognostic outcomes comparable to those of traditional radical surgery,with the advantages of fewer postoperative complications and superior cosmetic results.This approach is worthy of clinical promotion and application,particularly for early-stage breast cancer patients who have a demand for preserving breast morphology.
文摘AIM:To investigate the long-term outcomes in acute primary angle closure(APAC)patients treated with lens extraction(LE)surgery and to identify risk factors for glaucomatous optic neuropathy(GON).METHODS:In this longitudinal observational study,detailed medical histories of APAC patients and comprehensive ophthalmic examinations at final followup were collected.Logistic regression analysis was performed to identify predictors of blindness.Univariate and multivariate linear regression analyses were conducted to determine risk factors associated with visual outcomes.RESULTS:This study included 39 affected eyes of 31 subjects(26 females)with an average age of 74.1±8.0y.At 6.7±4.2y after APAC attack,2(5.7%)eyes had bestcorrected visual acuity(VA)worse than 3/60.Advanced glaucomatous visual field loss was observed in 15(39.5%)affected eyes and 5(25.0%)fellow eyes.Nine affected eyes(23.7%)had GON,and 11(28.9%)were blind.Six(15.4%)affected eyes and 2(9.1%)fellow eyes had suspicious progression.A significantly higher blindness rate in factory workers compared to office workers.Logistic regression identified that worse VA at attack(OR 10.568,95%CI 1.288-86.695;P=0.028)and worse early postoperative VA(OR 13.214,95%CI 1.157-150.881;P=0.038)were risk factors for blindness.Multivariate regression showed that longer duration of elevated intraocular pressure(P=0.004)and worse early postoperative VA(P=0.009)were associated with worse visual outcomes.CONCLUSION:Despite LE surgery,some APAC patients experience continued visual function deterioration.Lifelong monitoring is necessary.Target pressure and progression rates should be re-evaluated during follow-up.
文摘Taking the rural low-income population of Zhejiang Province as its subject, this paper examines how to build a sustainable income-growth mechanism and identify feasible implementation paths within the context of the common prosperity strategy. The research identifies key obstacles to income expansion, including an undiversified industrial structure, insufficient human capital, and a lack of robust social protection. These call for systemic solutions featuring institutional innovation, resource consolidation, and capability enhancement. Building on Zhejiang's experience as a common prosperity demonstration zone, the article constructs an integrated framework centered on four pillars: industrial empowerment, education upgrading, social security reinforcement, and digital coordination. It further offers concrete policy proposals involving the cultivation of localized industries, vocational skill training, enhanced safety nets, and the adoption of digital tools. The study thus offers both theoretical insights and practical paradigms for tackling the challenge of raising incomes in low-income rural areas.
基金financially supported by the National Science & Technology Fundamental Resources Investigation Project of China (2021FY100501)the Youth Innovation of Chinese Academy of Agricultural Sciences (Y2023QC16)。
文摘Long-term manure application has the potential to alleviate soil acidification, and increase carbon sequestration and nutrient availability, thus improving cropland fertility. However, the mechanisms behind greenhouse gas N_(2)O emissions from acidic soil mediated by long-term manure application remain poorly understood. Herein, we investigated N_(2)O emission and its linkage with gross N mineralization and nitrification rates, as well as nitrifying and denitrifying microbes in an acidic upland soil subjected to 36-year fertilization treatments, including an unfertilized control(CK), inorganic fertilizer(F), 2× rate of inorganic fertilizer(2F), manure(M), and the combination of inorganic fertilizer and manure(FM) treatments. Compared to the CK treatment(1.34 μg N kg^(-1) d^(-1)), fertilization strongly increased N_(2)O emissions by 34-fold on average, with more pronounced increases in the manure-amendment(10.6-169 μg N kg^(-1) d^(-1)) than those in the inorganic fertilizer treatments(3.26-5.51 μg N kg^(-1) d^(-1)). The manure amendment-stimulated N_(2)O emissions were highly associated with increased soil pH, mean weight diameter of soil aggregates, substrate availability(e.g., particulate organic carbon, NO_(3)^(-)and available phosphorus), gross N mineralization rates, denitrifier abundances and the(nirK+nirS)/nosZ ratio. These findings suggest that the increased N_(2)O emissions primarily resulted from alleviated acidification, increased substrate availability and improved soil structure, thus enhancing microbial N mineralization and favoring N_(2)O^(-)producing denitrifiers over N_(2)O consumers. Moreover, ammonia-oxidizing bacteria(AOB) rather than ammonia-oxidizing archaea(AOA) positively correlated with soil NO_(3)^(-)concentration and N_(2)O emissions, indicating that nitrification indirectly contributed to N_(2)O production by supplying NO_(3)^(-)for denitrification. Collectively, manure amendment potentially stimulates N_(2)O emissions, primarily resulting from alleviated soil acidification and increased substrate availability, thus enhancing N mineralization and denitrifier-mediated N_(2)O production. Our findings suggest that consideration should be given to the greenhouse gas budgets of agricultural ecosystems when applying manure for managing the pH and fertility of acidic soils.
基金Project(52373065)supported by the National Natural Science Foundation of ChinaProject(2220004002898)supported by the Zhuhai Industry University Research Cooperation and Basic and Applied Research Projects,China。
文摘Waterborne acrylic coatings are widely utilized due to their cost-effectiveness,high transparency,strong resistance to weather and chemicals,impressive mechanical properties,and excellent adhesion to various substrates.In these coatings,a reactive emulsifier containing phosphate groups can be integrated into the molecular chain during polymerization,which enhances the coating's compactness and corrosion resistance.This work focuses on the synthesis of styrene-butyl acrylate(St-BA)latex and methyl methacrylate-butyl acrylate(MMA-BA)latex using the reactive phosphate emulsifier ANPEO_(10)-P_(1) through seed emulsion polymerization,achieving a conversion rate of approximately 99%and a solid content close to 50%.The resulting coatings from St-BA and MMA-BA latexes demonstrated long-term corrosion protection for carbon steel and aluminum alloy due to in-situ phosphatization,effectively preventing flash rust.Notably,the MMA-BA coating exhibited remarkable durability,enduring immersion for up to 1224 h(51 d)on Q 235 carbon steel before reaching the failure threshold(|Z|0.01 Hz£106Ω·cm^(2))on Q 235 carbon steel.On 5052 aluminum alloy,the St-BA coating maintained|Z|0.01 Hz>10^(8)Ω·cm^(2) for 480 h(20 d).Furthermore,the corrosion resistance of St-BA and MMA BA coatings on Q 235 steel sheet and 5052 aluminum alloy surpassed that of commercially available MMA-BA and St BA coatings after immersion in a 3.5 wt%NaCl aqueous solution.This work also delves into the anticorrosion mechanism of MMA-BA and St-BA coatings.
基金In the process,this project was supported by the Fundamental Research Funds for the Central Universities(2572017DB02)the natural science foundation of heilongjiang province(LH2019E005)Harbin science and technology innovation talent fund project(2017RAQXJ086).
文摘Creep is an important characteristic of bamboo and wood materials under long-term loading.This paper aims to study the long-term bending beha-viour of prestressed glulam bamboo-wood beam(GBWB).For this,14 pre-stressed GBWBs were selected and subjected to a long-term loading test for 60 days.Then,a comparative analysis was performed for the effects of pre-tension values,the number of pre-stressed wires,and long-term load on the stress variation of the steel wire and the long-term deflection of the beam midspan.The test results showed that with the number of prestressed wires increasing,the total stress of the steel wire in the beam midspan and the ratio of the long-term deflec-tion to the total deflection decreases decreased,but when the number of steel wires exceeded 4,the total stress and long-term deflection was less infuenced;with the pre-tension value increasing,the ratio of the total stress of the steel wire in the beam midspan and the ratio of the long-temm deflection to the total deflec-tion also decreased,but when the prestress force was greater than 3.975 kN,the:total stress and long-term deflection were less affected;with the other parameters unchanged,when the value of the long-term load increased,the total stress of the steel wire decreased,and the long-temm deflection of the beam midspan increased,which shall be more significant with the long-term load greater than 30%of the standard ultimate bearing capacity.After the test,the experimental data were fitted,and the creep coefficient was given.Finally,the long-term stiffness calcula-tion fommula of the pre-stressed GBWB based on creep effect was proposed.The research findings have certain theoretical significance and engineering value.
基金supported by the National Natural Science Foundation of China(Nos.52003148 and 52261045)the State Key Laboratory of Marine Resource Utilization in South China Sea,Hainan University(No.MRUKF2021023)+3 种基金the Key Research and Development Project of Shaanxi Province(No.2023-YBGY-475)the Key Scientific Research Project of Education Department of Shaanxi Province(No.22JS003)the Industrialization Project of the State Key Laboratory of Biological Resources and Ecological Environment(Cultivation)of Qinba Region(No.SXC-2310)the key cultivation project funds of Shaanxi University of Technology(No.SLGKYXM2201).
文摘Polyurethane-fluorinated polysiloxane(PU-^(F)PDMS)with high-strength,high-bonding and low surface en-ergy is synthesized as the matrix,and the PU-^(F)PDMS/MCs/Ag marine anti-fouling coating on the sur-face of imitation crab shells is constructed by assembling butenolide@1,1-stilbene-modified hydrolyzed polyglycidyl methacrylate/graphene oxide microcapsules(Bu@PGMAm/GO MCs)with compact multi-shell structure and Ag nanoparticles(AgNPs)step by step on the PU-^(F)PDMS matrix.The PU-^(F)PDMS/MCs/Ag bionic anti-fouling coatings achieve long-term and stable anti-fouling effect under the combination of robust low-surface-energy PU-^(F)PDMS matrix,steady-state sustained release of butenolide encapsulated by the compact multi-shell,bionic surface formed by the microcapsules and AgNPs,and the release of Ag^(+).The shear strength,tensile strength,and elongation at break of the PU-^(F)PDMS/MCs/Ag are 3.53 MPa,6.7 MPa,and 192.83%,respectively.Its static contact angle and sliding angle are 161.8°and 3.6°,respectively.The antibacterial rate of PU-^(F)PDMS/MCs/Ag against Escherichia coli,Staphylococcus aureus,and Candida albicans can reach 100%.Compared with glass blank,PU,PU-^(F)PDMS,PU-^(F)PDMS/Ag,and PU-^(F)PDMS/MCs,both the adhesion number and coverage percentage of chlorella adhere to PU-^(F)PDMS/MCs/Ag are the minimum values,which are 600 cell mm^(-2) and 1.53%,respectively.After 6 months of marine field test,the primer blank,PU,PU-^(F)PDMS all show different degrees of attachment by shellfish,spirorbis,al-gae and other biofouling,while the PU-^(F)PDMS/MCs/Ag coating is still not covered with biofouling,while the PU-^(F)PDMS/MCs/Ag coatings still exhibit little attachment of marine fouling.The PU-^(F)PDMS/MCs/Ag bionic anti-fouling coatings are expected to be widely used in the fields of anti-fouling,anti-icing,anti-fogging,drag reduction,self-cleaning,and antibacterial.
基金supported by the Tianjin Municipal Natural Science Foundation(No.23JCYBJC00040)the National Nat-ural Science Foundation of China(No.52175369)the Tian-jin Research Innovation Project for Postgraduate Students(No.2022SKY134).
文摘To enhance the anti-corrosion performance of TC4 alloy across a wide temperature range for modern aircrafts operating in increasingly harsh environments, the (TiB+TiC) hybrid reinforced TC4 composites were prepared by laser melting deposition (LMD) via the in-situ reaction between B_(4)C reinforcement and molten TC4 alloy. The effect of B_(4)C content (0, 0.5, 1.5, wt%) on the microstructure and room/high-temperature corrosion behaviour of the composites was investigated. Microstructural analysis revealed that the microstructure of the composites was significantly influenced by the B_(4)C content. The composite containing 0.5 wt% B_(4)C exhibited an optimal microstructure characterized by refined grains, equiaxed α-Ti transformed from lath-shaped α-Ti, well-distributed (TiB+TiC) phases with a proper amount and reduced pore/dislocation defects. This composite also demonstrated the best corrosion resistance at both room temperature (25 ℃) and high temperature (800 ℃), which was primarily attributed to its comprehensive advantages including a favorable microstructure, a uniform dispersion of thermally stable (TiB+TiC) phases and a stable passivation film.
基金the National Natural Science Foundation of China(Nos.U2106226,52105297)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.52021003)the Science and Technology Development Project of Jilin Province(Nos.20210203022SF,20210508029RQ).
文摘Superhydrophobic surface is a promising strategy for antibacterial and corrosion protection.However,the use of harmful fluorine-containing materials,poor mechano-chemical stability,the addition of fungicides and poor corrosion resistance often limit its practical application.In this paper,a high-robustness pho-tothermal self-healing superhydrophobic coating is prepared by simply spraying a mixture of hydropho-bically modified epoxy resin and two kinds of modified nanofillers(carbon nanotubes and SiO2)for long-term anticorrosion and antibacterial applications.Multi-scale network and lubrication structures formed by cross-linking of modified carbon nanotubes and repeatable roughness endow coating with high ro-bustness,so that the coating maintains superhydrophobicity even after 100 Taber abrasion cycles,20 m sandpaper abrasion and 100 tape peeling cycles.The synergistic effect of antibacterial adhesion and pho-tothermal bactericidal activity endows coating with excellent antibacterial efficiency,which against Es-cherichia coli(E.coli)and Staphylococcus aureus(S.aureus)separately reaches 99.6% and 99.8%.Moreover,the influence of modified epoxy resin,superhydrophobicity,organic coating and coating thicknesses on the anticorrosion of magnesium(Mg)alloy is systematically studied and analyzed.More importantly,the prepared coating still exhibits excellent self-cleaning,anticorrosion and antibacterial abilities after 20 m abrasion.Furthermore,the coating exhibits excellent adhesion(level 4B),chemical stability,UV radiation resistance,high-low temperature alternation resistance,stable heat production capacity and photother-mal self-healing ability.All these excellent performances can promote its application in a wider range of fields.
基金supported by grants from the Medical Engineering Jiont Fund of the Fudan University(No.IDH2310117)。
文摘Objective:Triple-negative breast cancer(TNBC)is a highly aggressive subtype that lacks targeted therapies,leading to a poorer prognosis.However,some patients achieve long-term recurrence-free survival(RFS),offering valuable insights into tumor biology and potential treatment strategies.Methods:We conducted a comprehensive multi-omics analysis of 132 patients with American Joint Committee on Cancer(AJCC)stage III TNBC,comprising 36 long-term survivors(RFS≥8 years),62 moderate-term survivors(RFS:3-8 years),and 34 short-term survivors(RFS<3 years).Analyses investigated clinicopathological factors,whole-exome sequencing,germline mutations,copy number alterations(CNAs),RNA sequences,and metabolomic profiles.Results:Long-term survivors exhibited fewer metastatic regional lymph nodes,along with tumors showing reduced stromal fibrosis and lower Ki67 index.Molecularly,these tumors exhibited multiple alterations in genes related to homologous recombination repair,with higher frequencies of germline mutations and somatic CNAs.Additionally,tumors from long-term survivors demonstrated significant downregulation of the RTK-RAS signaling pathway.Metabolomic profiling revealed decreased levels of lipids and carbohydrate,particularly those involved in glycerophospholipid,fructose,and mannose metabolism,in long-term survival group.Multivariate Cox analysis identified fibrosis[hazard ratio(HR):12.70,95%confidence interval(95%CI):2.19-73.54,P=0.005]and RAC1copy number loss/deletion(HR:0.22,95%CI:0.06-0.83,P=0.026)as independent predictors of RFS.Higher fructose/mannose metabolism was associated with worse overall survival(HR:1.30,95%CI:1.01-1.68,P=0.045).Our findings emphasize the association between biological determinants and prolonged survival in patients with TNBC.Conclusions:Our study systematically identified the key molecular and metabolic features associated with prolonged survival in AJCC stage III TNBC,suggesting potential therapeutic targets to improve patient outcomes.
文摘Road traffic flow forecasting provides critical information for the operational management of road mobility challenges, and models are used to generate the forecast. This paper uses a random process to present a novel traffic modelling framework for aggregate traffic on urban roads. The main idea is that road traffic flow is random, even for the recurrent flow, such as rush hour traffic, which is predisposed to congestion. Therefore, the structure of the aggregate traffic flow model for urban roads should correlate well with the essential variables of the observed random dynamics of the traffic flow phenomena. The novelty of this paper is the developed framework, based on the Poisson process, the kinematics of urban road traffic flow, and the intermediate modelling approach, which were combined to formulate the model. Empirical data from an urban road in Ghana was used to explore the model’s fidelity. The results show that the distribution from the model correlates well with that of the empirical traffic, providing a strong validation of the new framework and instilling confidence in its potential for significantly improved forecasts and, hence, a more hopeful outlook for real-world traffic management.
基金supported by the Russian science foundation(grant#22-74-00115 to A.P.G.).
文摘Background:Mitochondrial dysfunction plays a critical role in the pathogenesis of Alzheimer’s disease(AD).Resveratrol is a promising compound for the treatment of various neurodegenerative diseases,including AD.Aims:To investigate mitochondrial damage and the effects of resveratrol on inflammation,cognitive function,and mitochondrial quality control in APP/PS1 mice.Methods:Comparative analysis of mitochondrial DNA(mtDNA)damage was conducted between 10-month-old APP/PS1 mice and age-matched C57BL/6 mice.Assessments included measurement of amyloid-βlevels,inflammatory markers,swimming distance in the Morris water maze,and gut microbiome composition.Resveratrol’s effects on cytokine expression,mtDNA levels in plasma,and activation of Nuclear factor erythroid 2-related factor 2/Antioxidant response element(Nrf2/ARE)and phosphoinositide 3-kinase/protein kinase B(also known as Akt)/mechanistic target of rapamycin complex 1(PI3K/Akt/mTORC1)signaling pathways were also evaluated.Results:APP/PS1 mice exhibited significantly increased mtDNA damage in the prefrontal cortex,midbrain,and cerebellum,alongside higher amyloid-βlevels and inflammatory markers.Resveratrol treatment led to reduced expression of pro-inflammatory cytokines,a decrease in Proteobacteria levels,and lower cell-free mtDNA in plasma.Partial improvement in long-term spatial memory was observed in APP/PS1 mice following resveratrol treatment,likely due to its anti-inflammatory properties.Activation of the Nrf2/ARE signaling pathway and markers of PI3K/Akt/mTORC1 axis activation were noted,with the latter regulating long-term potentiation.Conclusion:Resveratrol demonstrates potential in mitigating inflammation and improving mitochondrial quality control in APP/PS1 mice,but it does not reduce amyloid-βlevels,highlighting the complexity of AD pathology and the need for further research.
文摘Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery complications.Despite the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical Cases.This editorial emphasizes the critical need for long-term management and regular surveillance to prevent such complications.By drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.
文摘The functionally graded materials(FGMs)are obtained by various processes.Although a few FGMs are obtained naturally,such as oyster,pearl,and bamboo,additive manufacturing(AM),known as 3D printing,is a net-shaped manufacturing process employed to manufacture complex 3D objects without tools,molds,assembly,and joining.Currently,commercial AM techniques mostly use homogeneous composition with simplified geometric descriptions,employing a single material across the entire component to achieve functional graded additive manufacturing(FGAM),in contrast to multi-material FGAM with heterogeneous structures.FGMs are widely used in various fields due to their mechanical property advantages.Because FGM plays a significant role in the industrial production,the characteristics and mechanical behaviour of FGMs prepared by AM were reviewed.In this review,the research on FGMs and AM over the past 30 years was reviewed,suggesting that future researchers should focus on the application of artificial intelligence and machine learning technologies in industry to optimize the process parameters of different gradient systems.
基金financially supported by the Scientific and Technological Plan Project of Guizhou Province ([2024]054)Additional support came from the Industry and Education Combination Innovation Platform of Intelligent Manufacturing and Graduate Joint Training Base at Guizhou University (2020-520000-83-01324061)the Guizhou Engineering Research Center for Smart Services (2203-520102-04-04-298868)。
文摘Aqueous sodium-ion batteries(ASIBs) offer significant advantages for energy storage on a large scale,attributed to their economical cost,secure operatio n,and eco-friend ly natu re.Among the leading cathode materials for ASIBs,Na_(3)V_(2)(PO_(4))_(3)(NVP) exhibits excellent structural stability and a high Na+diffusion coefficient,making it a promising option.However,the high solubility of vanadium-based materials in aqueous electrolytes engenders suboptimal cycling stability for Na_(3)V_(2)(PO_(4))_(3),constraining its application in ASIBs.Herein,the Cr-substituted Na_(3)V_(1.3)Cr_(0.7)(PO_(4))3@C(NV_(1.3)Cr_(0.7)P) cathode material was synthesized via a simple sol-gel method.It is found that Cr substitution reduces the cell parameters of NV_(1.3)Cr_(0.7)P,effectively reinforcing the crystal structure.Furthermore,NV_(1.3)Cr_(0.7)P alters the Na^(+)insertion/extraction mechanism,transforming the typical two-phase reaction between Na_(1)V_(2)(PO_(4))_(3)and Na_(3)V_(2)(PO_(4))3into continuous solid-solution reactions with stable intermediates.The Cr substitution diminishes the sodium-ion diffusion energy barrier in NV_(1.3)Cr_(0.7)P,leading to smoother Na+insertion and extraction processes.Consequently,NV_(1.3)Cr_(0.7)P exhibits impressive cycling stability,retaining 74.8% of its capacity after 5,000 cycles at a current density of 5 A g^(-1),along with an outstanding rate performance of 79,2% at 10 A g^(-1).This work elucidates the stable Na^(+)insertion/extraction processes in Cr-substituted NV_(1.3)Cr_(0.7)P,offering insights into the application of vanadium-based materials in aqueous sodium-ion batteries.
基金supported by the National Natural Science Foundation of China(No.42075177)the National Key Research and Development Program of China(No.2017YFC0210003).
文摘Extensive spatiotemporal analyses of long-trend surface ozone in the Yangtze River Delta(YRD)region and itsmeteorology-related and emission-related have not been systematically analyzed.In this study,by using 8-year-long(2015–2022)surface ozone observation data,we attempted to reveal the variation ofmultiple timescale components using the Kolmogorov–Zurbenko filter,and the effects of meteorology and emissions were quantitatively isolated using multiple linear regression with meteorological variables.The results showed that the short-term,seasonal,and long-term components accounted for daily maximum 8-hr average O_(3)(O_(3–8)hr)concentration,46.4%,45.9%,and 1.0%,respectively.The meteorological impacts account for an average of 71.8%of O_(3–8)hr,and the YRD’s eastern and northern sections aremeteorology-sensitive areas.Based on statistical analysis technology with empirical orthogonal function,the contribution of meteorology,local emission,and transport in the long-term component of O_(3–8)hr were 0.21%,0.12%,and 0.6%,respectively.The spatiotemporal analysis indicated that a distinct decreasing spatial pattern could be observed from coastal cities towards the northwest,influenced by the monsoon and synoptic conditions.The central urban agglomeration north and south of the YRD was particularly susceptible to local pollution.Among the cities studied,Shanghai,Anqing,and Xuancheng,located at similar latitudes,were significantly impacted by atmospheric transmission—the contribution of Shanghai,the maximum accounting for 3.6%.
