Long non-coding RNAs(lncRNAs)are a family of non-protein-coding RNAs that span a length of over 200 nucleotides.Research reports have illustrated that lncRNAs are involved in various cellular processes and that their ...Long non-coding RNAs(lncRNAs)are a family of non-protein-coding RNAs that span a length of over 200 nucleotides.Research reports have illustrated that lncRNAs are involved in various cellular processes and that their abnormal expression leads to the occurrence and development of various tumors.Colon cancer-associated transcript 2(CCAT2)was first reported as an oncogene in colon cancer.LncRNA CCAT2 is abnormally expressed in hepatocellular carcinoma,cholangiocarcinoma,lung cancer,breast cancer,ovarian cancer,glioma,and other tumors.In tumor tissues,abnormally overexpressed CCAT2 can affect cell proliferation,migration,epithelial-mesenchymal transition,apoptosis,and other biological behaviors through endogenous RNAs mechanisms,various signaling pathways,transcriptional regulation,and other complex mechanisms.Additionally,the overexpression of CCAT2 is also closely related to the tumor size,tumor node metastasis(TNM)stage,survival time,and other prognostic factors,suggesting that it is a potential prognostic indicator.This article reviews the biological functions of CCAT2 and its mechanisms of action in tumors from previous studies.In this review,we attempt to provide a molecular basis for future clinical applications of lncRNA CCAT2.展开更多
Prostate cancer remains a major health problem,with its incidence ranking second among male malignancies worldwide.Recent studies have highlighted the critical role of the SOX family transcription factors,especially S...Prostate cancer remains a major health problem,with its incidence ranking second among male malignancies worldwide.Recent studies have highlighted the critical role of the SOX family transcription factors,especially SOX2,in prostate cancer pathogenesis.SOX2 regulates the fate of cancer stem/progenitor cells,contributing to tumor initiation,development,and metastasis.Elevated SOX2 levels have been detected in prostate cancer tissues and are associated with higher tumor grade,aggressive phenotype,and poor prognosis.SOX2 also impacts various tumor biological behaviors,including cell proliferation,invasion,metastasis,resistance to apoptosis,and treatment resistance.This review highlights the role of SOX proteins in prostate cancer,focusing on the molecular mechanisms by which SOX2 drives cancer progression,elucidating the mechanisms controlling its activity,and emphasizing its potential as a therapeutic target.展开更多
基金Anhui Province Science Foundation(No.2008085MH256).
文摘Long non-coding RNAs(lncRNAs)are a family of non-protein-coding RNAs that span a length of over 200 nucleotides.Research reports have illustrated that lncRNAs are involved in various cellular processes and that their abnormal expression leads to the occurrence and development of various tumors.Colon cancer-associated transcript 2(CCAT2)was first reported as an oncogene in colon cancer.LncRNA CCAT2 is abnormally expressed in hepatocellular carcinoma,cholangiocarcinoma,lung cancer,breast cancer,ovarian cancer,glioma,and other tumors.In tumor tissues,abnormally overexpressed CCAT2 can affect cell proliferation,migration,epithelial-mesenchymal transition,apoptosis,and other biological behaviors through endogenous RNAs mechanisms,various signaling pathways,transcriptional regulation,and other complex mechanisms.Additionally,the overexpression of CCAT2 is also closely related to the tumor size,tumor node metastasis(TNM)stage,survival time,and other prognostic factors,suggesting that it is a potential prognostic indicator.This article reviews the biological functions of CCAT2 and its mechanisms of action in tumors from previous studies.In this review,we attempt to provide a molecular basis for future clinical applications of lncRNA CCAT2.
基金supported by National Natural Science Foundation of China(No.81860524)Zunyi Municipal Bureau of Industry,Science and Technology[Zun shi ke he HZ zi(2024)No.216]。
文摘Prostate cancer remains a major health problem,with its incidence ranking second among male malignancies worldwide.Recent studies have highlighted the critical role of the SOX family transcription factors,especially SOX2,in prostate cancer pathogenesis.SOX2 regulates the fate of cancer stem/progenitor cells,contributing to tumor initiation,development,and metastasis.Elevated SOX2 levels have been detected in prostate cancer tissues and are associated with higher tumor grade,aggressive phenotype,and poor prognosis.SOX2 also impacts various tumor biological behaviors,including cell proliferation,invasion,metastasis,resistance to apoptosis,and treatment resistance.This review highlights the role of SOX proteins in prostate cancer,focusing on the molecular mechanisms by which SOX2 drives cancer progression,elucidating the mechanisms controlling its activity,and emphasizing its potential as a therapeutic target.
