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Gamma-aminobutyric acid A receptors in Alzheimer's disease: highly localized remodeling of a complex and diverse signaling pathway 被引量:4
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作者 Andrea Kwakowsky Beatriz Calvo-Flores Guzman +2 位作者 Karan Govindpani Henry J. Waldvogel Richard L. Faull 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第8期1362-1363,共2页
Alzheimer's disease (AD), the predominant form of dementia, is a chronic, incurable neurodegenerative disorder presenting with symptoms includ- ing progressive memory loss and disturbed emotional state. It has been... Alzheimer's disease (AD), the predominant form of dementia, is a chronic, incurable neurodegenerative disorder presenting with symptoms includ- ing progressive memory loss and disturbed emotional state. It has been estimated that dementia affects over 47 million people worldwide (Prince et al., 2015), and with 60-80% of cases attributable to AD. 展开更多
关键词 AD highly localized remodeling of a complex and diverse signaling pathway Gamma-aminobutyric acid A receptors in Alzheimer’s disease
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The complex variable meshless local Petrov-Galerkin method of solving two-dimensional potential problems 被引量:1
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作者 杨秀丽 戴保东 张伟伟 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第10期49-55,共7页
Based on the complex variable moving least-square(CVMLS) approximation and a local symmetric weak form,the complex variable meshless local Petrov-Galerkin(CVMLPG) method of solving two-dimensional potential proble... Based on the complex variable moving least-square(CVMLS) approximation and a local symmetric weak form,the complex variable meshless local Petrov-Galerkin(CVMLPG) method of solving two-dimensional potential problems is presented in this paper.In the present formulation,the trial function of a two-dimensional problem is formed with a one-dimensional basis function.The number of unknown coefficients in the trial function of the CVMLS approximation is less than that in the trial function of the moving least-square(MLS) approximation.The essential boundary conditions are imposed by the penalty method.The main advantage of this approach over the conventional meshless local Petrov-Galerkin(MLPG) method is its computational efficiency.Several numerical examples are presented to illustrate the implementation and performance of the present CVMLPG method. 展开更多
关键词 meshless method complex variable moving least-square method complex variable meshless local Petrov-Galerkin method potential problems
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On the formation of shear bands in a metallic glass under tailored complex stress fields 被引量:2
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作者 S.H.Chen T.Li +6 位作者 W.J.Chang H.D.Yang J.C.Zhang H.H.Tang S.D.Feng F.F.Wu Y.C Wu 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2020年第18期112-117,共6页
The formation of shear bands in metallic glasses(MGs)was examined by tailoring localized complex stress fields(LCSFs).The findings have shown that the LCSFs in MGs can increase the localization of strained atoms and a... The formation of shear bands in metallic glasses(MGs)was examined by tailoring localized complex stress fields(LCSFs).The findings have shown that the LCSFs in MGs can increase the localization of strained atoms and accelerate the release of accumulated deformation energy for initiating a shear band in confined and thin-layered regions.The findings not only add more knowledge to the formation mechanisms of shear bands in MGs,but also provide possible rationale for the discrepancies in the mechanical properties of different-sized MGs.As compared with the bulk samples,the higher strength and larger elastic limits in nanoscaled MGs could be attributed to the elimination of stress-concentrators,which can serve as LCSFs. 展开更多
关键词 localized complex stress field Shear band Metallic glass Molecular dynamics simulation Size effect
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Software Analytics of Open Source Business Software
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作者 Charles W. Butler 《Journal of Software Engineering and Applications》 2022年第5期150-164,共15页
This paper applies software analytics to open source code. Open-source software gives both individuals and businesses the flexibility to work with different parts of available code to modify it or incorporate it into ... This paper applies software analytics to open source code. Open-source software gives both individuals and businesses the flexibility to work with different parts of available code to modify it or incorporate it into their own project. The open source software market is growing. Major companies such as AWS, Facebook, Google, IBM, Microsoft, Netflix, SAP, Cisco, Intel, and Tesla have joined the open source software community. In this study, a sample of 40 open source applications was selected. Traditional McCabe software metrics including cyclomatic and essential complexities were examined. An analytical comparison of this set of metrics and derived metrics for high risk software was utilized as a basis for addressing risk management in the adoption and integration decisions of open source software. From this comparison, refinements were added, and contemporary concepts of design and data metrics derived from cyclomatic complexity were integrated into a classification scheme for software quality. It was found that 84% of the sample open source applications were classified as moderate low risk or low risk indicating that open source software exhibits low risk characteristics. The 40 open source applications were the base data for the model resulting in a technique which is applicable to any open source code regardless of functionality, language, or size. 展开更多
关键词 Cyclomatic complexity Essential complexity Module Design complexity Design complexity Integration complexity local Data complexity Public Global Data complexity Parameter Data complexity Risk Application Risk Score Application Risk Classification
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Software Metric Analysis of Open-Source Business Software
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作者 Charles W. Butler 《Journal of Software Engineering and Applications》 2023年第5期144-153,共10页
Over the past decade, open-source software use has grown. Today, many companies including Google, Microsoft, Meta, RedHat, MongoDB, and Apache are major participants of open-source contributions. With the increased us... Over the past decade, open-source software use has grown. Today, many companies including Google, Microsoft, Meta, RedHat, MongoDB, and Apache are major participants of open-source contributions. With the increased use of open-source software or integration of open-source software into custom-developed software, the quality of this software component increases in importance. This study examined a sample of open-source applications from GitHub. Static software analytics were conducted, and each application was classified for its risk level. In the analyzed applications, it was found that 90% of the applications were classified as low risk or moderate low risk indicating a high level of quality for open-source applications. 展开更多
关键词 Open-Source Software Software Quality Software Risks Cyclomatic complexity Essential complexity Module Design complexity Design complexity Integration complexity local Data complexity Public Global Data complexity Parameter Data complexity Risk Score Risk Classification
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