Auditory verbal hallucination(AVH)is emphasized as a pathological hallmark of schizophrenia.Neuroimaging studies provide evidence linking AVH to overlapping functional abnormalities in distributed networks.However,no ...Auditory verbal hallucination(AVH)is emphasized as a pathological hallmark of schizophrenia.Neuroimaging studies provide evidence linking AVH to overlapping functional abnormalities in distributed networks.However,no clear conclusion has still been reached.This study aimed to further explore the brain activity of patients with schizophrenia having AVH from both local activity(LA)and functional connectivity(FC)insights,while excluding confounding factors from other positive symptoms.A total of 42 patients with AVH(AVH patients group,APG),26 without AVH(non-AVH patients group,NPG),and 82 normal controls(NC)underwent resting-state functional magnetic resonance imaging(fMRI).LA measures,including regional homogeneity(ReHo)and fractional amplitude of low-frequency fluctuations(fALFF),and FC measures were evaluated to understand the neuroimaging mechanism of AVH.APG showed increased ReHo and fALFF in the bilateral putamen(Put)compared with NPG and NC.FC analysis(using bilateral putamen as seeds)revealed that all patients showed abnormal FC of multiple resting state network regions,including the anterior and post cingulate cortex,middle frontal gyrus,inferior parietal gyrus,and left angular gyrus.Interestingly,APG showed significantly decreased FC of insula extending to the superior temporal gyrus and inferior frontal gyrus compared with NPG and NC.The present findings suggested a significant correlation of abnormal LA and dysfunctional putamen-auditory cortical connectivity with the neuropathological mechanism of AVH,providing evidence for the functional disconnection hypothesis of schizophrenia.展开更多
The theorems for testing the local in one-port cellular neural/inear network (CNN) cells with four local state variables are presented. Using the theorems computes the bifurcation diagrams of the cardiac Purkinje f...The theorems for testing the local in one-port cellular neural/inear network (CNN) cells with four local state variables are presented. Using the theorems computes the bifurcation diagrams of the cardiac Purkinje fiber (CPE) equations Which describethe long-lasting action and pace-maker potentials of the Purkinje fiber of the heart. The computer simulation shows that periodic trajectories or convergent trajectories of the CPF Equations can be foun if the cormsponing cell Parameters are located in a positive domainbut nearby edge of chaos. In particular a heart with approximate normal frequency of heartbeat but non-normal electrocardiogram maysuddenly stop by slightly perturbing the parameters of the corresponding CPF Equations when the Paramders are located nearby the edge of chaos in the bifurcation diagrams. This research seems to interpret reasonbly the phenomena that patients with cardiac diseases might suddenly die without warning.展开更多
Presents analytic criteria for the local activity theory in two-port cellularneural network (CNN) cells with four local state variables, and gives the application to a smoothedChua's circuit (SCC) CNN with two-por...Presents analytic criteria for the local activity theory in two-port cellularneural network (CNN) cells with four local state variables, and gives the application to a smoothedChua's circuit (SCC) CNN with two-port and I 5 S 15 arrays. The bifurcation diagrams of the SCC CNNshow that they are completely the same as those of an SCC CNN with one-port calculated earlier;which do not exist locally passive domain. The evolution of the patterns of the state variables ofthe SCC CNN is stimulated. Oscillatory patterns, chaotic patterns, or divergent patterns may emergeif the selected cell parameters are located in the locally active unstable domains but nearby theedge of chaos domain.展开更多
The analytic criteria for the local activity theory in one-port cellularneural network (CNN) with five local state variables are presented. The application to a Hyper-chaossynchronization Chua's circuit (HCSCC) CN...The analytic criteria for the local activity theory in one-port cellularneural network (CNN) with five local state variables are presented. The application to a Hyper-chaossynchronization Chua's circuit (HCSCC) CNN with 1125 variables is studied. The bifurcation diagramsof the HCSCC CNN show that they are slightly different from the smoothed CNN with one or two portsand four state variables calculated earlier. The evolution of the patterns of the state variables ofthe HCSCC CNN is stimulated. Oscillatory patterns, chaotic patterns, convergent or divergentpatterns may emerge if the selected cell parameters are located in the locally active domains butnearby or in the edge of chaos domain.展开更多
Complexity and abundant dynamics may arise in locally-active systems only, in which locally-active elements are essential to amplify infinitesimal fluctuation signals and maintain oscillating. It has been recently fou...Complexity and abundant dynamics may arise in locally-active systems only, in which locally-active elements are essential to amplify infinitesimal fluctuation signals and maintain oscillating. It has been recently found that some memristors may act as locally-active elements under suitable biasing. A number of important engineering applications would benefit from locally-active memristors. The aim of this paper is to show that locally-active memristor-based circuits can generate periodic and chaotic oscillations. To this end, we propose a non-volatile locally-active memristor, which has two asymptotically stable equilibrium points(or two non-volatile memristances) and globally-passive but locally-active characteristic. At an operating point in the locally-active region, a small-signal equivalent circuit is derived for describing the characteristics of the memristor near the operating point. By using the small-signal equivalent circuit, we show that the memristor possesses an edge of chaos in a voltage range, and that the memristor, when connected in series with an inductor,can oscillate about a locally-active operating point in the edge of chaos. And the oscillating frequency and the external inductance are determined by the small-signal admittance Y(iω). Furthermore, if the parasitic capacitor in parallel with the memristor is considered in the periodic oscillating circuit, the circuit generates chaotic oscillations.展开更多
Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-...Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-CA1),as well as to investigate the mechanism of acupuncture in the treatment of gynecological diseases.Methods Twenty-two healthy female subjects were stimulated by electroacupuncture at bilateral uterine acupoints;rs-f MRI data of the brain were acquired and standardized.Degree centrality(DC),amplitude of low-frequency fluctuation(ALFF),and regional homogeneity(ReHo)were used to analyze local spontaneous brain activity via acupuncture.An independent component analysis was used to evaluate the functional connectivity of the resting brain networks after acupuncture.Results Analytical results showed that the neural activity intensity of the precuneus lobe,orbitofrontal cortex,lingual gyrus,amygdala,and posterior central gyrus decreased after acupuncture(voxel P<0.001,cluster P<0.05).Functional connectivity analysis revealed weakened auditory and right frontal-parietal networks(voxel P<0.001,cluster P<0.05),enhanced visual network(voxel P<0.001,cluster P<0.05),and synergistic auditory network and hypothalamic-pituitary system.Conclusion Significant differences in neural activity and functional connectivity in specific brain regions were observed after acupuncture intervention at uterine acupoints;the hypothalamic-pituitary system also showed various active states in different brain regions.It is speculated that the effective mechanism of acupuncture at uterine acupoints is related to the regulation of reproductive hormones,emotional changes,and somatic sensations.Therefore,the methods used in this study could clarify the neural mechanism of uterine-point acupuncture in the treatment of gynecological diseases and may serve as a reference for other studies pertaining to acupuncture.展开更多
In order to make the peak and offset of the signal meet the requirements of artificial equipment,dynamical analysis and geometric control of the laser system have become indispensable.In this paper,a locally active me...In order to make the peak and offset of the signal meet the requirements of artificial equipment,dynamical analysis and geometric control of the laser system have become indispensable.In this paper,a locally active memristor with non-volatile memory is introduced into a complex-valued Lorenz laser system.By using numerical measures,complex dynamical behaviors of the memristive laser system are uncovered.It appears the alternating appearance of quasi-periodic and chaotic oscillations.The mechanism of transformation from a quasi-periodic pattern to a chaotic one is revealed from the perspective of Hamilton energy.Interestingly,initial-values-oriented extreme multi-stability patterns are found,where the coexisting attractors have the same Lyapunov exponents.In addition,the introduction of a memristor greatly improves the complexity of the laser system.Moreover,to control the amplitude and offset of the chaotic signal,two kinds of geometric control methods including amplitude control and rotation control are designed.The results show that these two geometric control methods have revised the size and position of the chaotic signal without changing the chaotic dynamics.Finally,a digital hardware device is developed and the experiment outputs agree fairly well with those of the numerical simulations.展开更多
At present, many neuron models have been proposed, which can be divided into discrete neuron models and continuous neuron models. Discrete neuron models have the advantage of faster simulation speed and the ease of un...At present, many neuron models have been proposed, which can be divided into discrete neuron models and continuous neuron models. Discrete neuron models have the advantage of faster simulation speed and the ease of understanding complex dynamic phenomena. Due to the properties of memorability, nonvolatility, and local activity, locally active discrete memristors(LADMs) are also suitable for simulating synapses. In this paper, we use an LADM to mimic synapses and establish a Rulkov neural network model. It is found that the change of coupling strength and the initial state of the LADM leads to multiple firing patterns of the neural network. In addition, considering the influence of neural network parameters and the initial state of the LADM, numerical analysis methods such as phase diagram and timing diagram are used to study the phase synchronization. As the system parameters and the initial states of the LADM change, the LADM coupled Rulkov neural network exhibits synchronization transition and synchronization coexistence.展开更多
The number of foreign students studying in Wenzhou, China has increased dramatically as a result of the Belt and Road Initiative. Learning the motivations and leisure constraints of foreign students' participation...The number of foreign students studying in Wenzhou, China has increased dramatically as a result of the Belt and Road Initiative. Learning the motivations and leisure constraints of foreign students' participation in local cultural and folk activities in Wenzhou is beneficial to promoting cultural adaptation, strengthening Chinese cultural self-confidence, and improving Wenzhou's international image. Based on the hierarchical model of leisure constraints (personal constraints, interpersonal constraints, and structural constraints), this study has tended to focus on the leisure constraints for foreign students participating in local folk and cultural activities in Wenzhou. A total of seven participants were included in the analysis.展开更多
By considering the heterogeneity of geomechanical materials, the source development of earthquake under compression boundary conditions is studied with a newly developed numerical method, Rock Failure Process Analysis...By considering the heterogeneity of geomechanical materials, the source development of earthquake under compression boundary conditions is studied with a newly developed numerical method, Rock Failure Process Analysis code (RFPA2D). The process of fault forming and associated micro seismicities in a rectangle area with a inclusion but without any clear structural features of original fault is modeled. The modeling demonstrates the whole process of source development of earthquake from deformation, micro failure to collapse and the behavior of temporal spatial distribution of micro seismicities. The stress, strain and the temporal spatial distribution of micro seismicities vividly depict the phenomena of localization, temporal transitions, dilatation or rise, elastic rebound and conjugate (X type) deformation zone.展开更多
The crystallization kinetics of Pd-Cu-Si glass was studied by means of diferential scanning calorimetry-Ⅱ.According to Kissinger peak shift methd and Arrhenius equation,the apparent activation energy was calculated.T...The crystallization kinetics of Pd-Cu-Si glass was studied by means of diferential scanning calorimetry-Ⅱ.According to Kissinger peak shift methd and Arrhenius equation,the apparent activation energy was calculated.The crystallization kinetics follows Johnson- Mehl-Avrami equation with n=3.0 within 0.15<x<0.85.In isothermal treatment,the concepts of local Avrami exponent and local activation energy have been introduced into Pd-Cu-Si system for understanding the isothermal crystallization process.展开更多
By precisely controlling both active sites and their surrounding microenvironments,enzymes catalyze complex transformations with remarkable efficiency and selectivity.This intricate interplay of structure and function...By precisely controlling both active sites and their surrounding microenvironments,enzymes catalyze complex transformations with remarkable efficiency and selectivity.This intricate interplay of structure and function in natural enzymes has inspired the emerging field of precision catalysis,which seeks to similarly modify active site architecture and local environments to enhance catalytic activity and selectivity in nonenzymaticsystems.Precision catalysis aims to enhance activity and selectivity,rivaling natural enzymes while achieving greater atom economy in catalyst design.Among various material platforms,metal-organic frame-works(MOFs)are uniquely positioned to advance precision catalysis due to their modular construction,structural regularity,and synthetic tunability.MOFs are porous crystalline molecular materials built from metal clusters and organic linkers.Their reticular nature enables the rational synthesis of hundreds of thousands of MOFs with diverse topologies and compositions.2 Unlike conventional homogeneous or heterogeneous catalysts,MOFs allow for atomic-level spatial control over the placement of catalytic sites.展开更多
The current targeting drug delivery mainly relies on cancer cell surface receptors.However,in many cases,binding affinities between protein receptors and homing ligands is relatively low and the expression level betwe...The current targeting drug delivery mainly relies on cancer cell surface receptors.However,in many cases,binding affinities between protein receptors and homing ligands is relatively low and the expression level between cancer and normal cells is not significant.Distinct from conventional targeting strategies,we have developed a general cancer targeting platform by building artificial receptor on cancer cell surface via a chemical remodeling of cell surface glycans.A new tetrazine(Tz)functionalized chemical receptor has been designed and efficiently installed on cancer cell surface as“overexpressed”biomarker through a metabolic glycan engineering.Different from the reported bioconjugation for drug targeting,the tetrazine labeled cancer cells not only locally activate TCO-caged prodrugs but also release active drugs via the unique bioorthogonal Tz-TCO click-release reaction.The studies have demonstrated that the new drug targeting strategy enables local activation of prodrug,which ultimately leads to effective and safe cancer therapy.展开更多
Can WiFi signals be used for sensing purpose？ The growing PHY layer capabilities of WiFi has made it possible to reuse WiFi signals for both communication and sensing. Sensing via WiFi would enable remote sensing wit...Can WiFi signals be used for sensing purpose？ The growing PHY layer capabilities of WiFi has made it possible to reuse WiFi signals for both communication and sensing. Sensing via WiFi would enable remote sensing without wearable sensors, simultaneous perception and data transmission without extra communication infrastructure, and contactless sensing in privacy-preserving mode. Due to the popularity of WiFi devices and the ubiquitous deployment of WiFi networks, WiFi-based sensing networks, if fully connected, would potentially rank as one of the world＇s largest wireless sensor networks. Yet the concept of wireless and sensorless sensing is not the simple combination of WiFi and radar. It seeks breakthroughs from dedicated radar systems, and aims to balance between low cost and high accuracy, to meet the rising demand for pervasive environment perception in everyday life. Despite increasing research interest, wireless sensing is still in its infancy. Through introductions on basic principles and working prototypes, we review the feasibilities and limitations of wireless, sensorless, and contactless sensing via WiFi. We envision this article as a brief primer on wireless sensing for interested readers to explore this open and largely unexplored field and create next-generation wireless and mobile computing applications.展开更多
Although presurgical evaluation of patients with pharamacoresistent focal epilepsies provides essential information for successful epilepsy surgery,there is still a need for further improvement.Developments of noninva...Although presurgical evaluation of patients with pharamacoresistent focal epilepsies provides essential information for successful epilepsy surgery,there is still a need for further improvement.Developments of noninvasive electrophysiological recording and analysis techniques offer additional information based on interictal and ictal epileptic activities.In this review,we provide an overview on the application of ictal magnetoencephalography(MEG).The results of a literature research for published interictal/ictal MEG findings and experiences with own cases are demonstrated and discussed.Ictal MEG may provide added value in comparison to interictal recordings.The results may be more focal and closer to the invasively determined seizure onset zone.In some patients without clear interictal findings,ictal MEG could provide correct localization.Novel recording and analysis techniques facilitate ictal recordings.However,extended recording durations,movement and artifacts still represent practical limitations.Ictal MEG may provide added value regarding the localization of the seizure onset zone but depends on the selection of patients and the application of optimal analysis techniques.展开更多
Background:The pathogenesis of neck pain in the brain,which is the fourth most common cause of disability,remains unclear.Furthermore,little is known about the characteristics of dynamic local functional brain activit...Background:The pathogenesis of neck pain in the brain,which is the fourth most common cause of disability,remains unclear.Furthermore,little is known about the characteristics of dynamic local functional brain activity in cervical pain.Objective:The present study aimed to investigate the changes of local brain activity caused by chronic neck pain and the factors leading to neck pain.Methods:Using the amplitude of low-frequency fluctuations(ALFF)method combined with sliding window approach,we compared local brain activity that was measured by the functional magnetic resonance imaging(fMRI)of 107 patients with chronic neck pain(CNP)with that of 57 healthy control participants.Five pathogenic factors were selected for correlation analysis.Results:The group comparison results of dynamic amplitude of low-frequency fluctuation(dALFF)variability showed that patients with CNP exhibited decreased dALFF variability in the left inferior temporal gyrus,the middle temporal gyrus,the angular gyrus,the inferior parietal marginal angular gyrus,and the middle occipital gyrus.The abnormal dALFF variability of the left inferior temporal gyrus was negatively correlated with the average daily working hours of patients with neck pain.Conclusions:The findings indicated that the brain regions of patients with CNP responsible for audition,vision,memory,and emotion were subjected to temporal variability of abnormal regional brain activity.Moreover,the dALFF variability in the left inferior temporal gyrus might be a risk factor for neck pain.This study revealed the brain dysfunction of patients with CNP from the perspective of dynamic local brain activity,and highlighted the important role of dALFF variability in understanding the neural mechanism of CNP.展开更多
基金'This study was supported by grants from the National 973 Program of China(No.201 lCB707805)the National Natural Science Foundation of China(No.91132301)the Natural Science Foundation of Hubei Province(No.2014CFB732).
文摘Auditory verbal hallucination(AVH)is emphasized as a pathological hallmark of schizophrenia.Neuroimaging studies provide evidence linking AVH to overlapping functional abnormalities in distributed networks.However,no clear conclusion has still been reached.This study aimed to further explore the brain activity of patients with schizophrenia having AVH from both local activity(LA)and functional connectivity(FC)insights,while excluding confounding factors from other positive symptoms.A total of 42 patients with AVH(AVH patients group,APG),26 without AVH(non-AVH patients group,NPG),and 82 normal controls(NC)underwent resting-state functional magnetic resonance imaging(fMRI).LA measures,including regional homogeneity(ReHo)and fractional amplitude of low-frequency fluctuations(fALFF),and FC measures were evaluated to understand the neuroimaging mechanism of AVH.APG showed increased ReHo and fALFF in the bilateral putamen(Put)compared with NPG and NC.FC analysis(using bilateral putamen as seeds)revealed that all patients showed abnormal FC of multiple resting state network regions,including the anterior and post cingulate cortex,middle frontal gyrus,inferior parietal gyrus,and left angular gyrus.Interestingly,APG showed significantly decreased FC of insula extending to the superior temporal gyrus and inferior frontal gyrus compared with NPG and NC.The present findings suggested a significant correlation of abnormal LA and dysfunctional putamen-auditory cortical connectivity with the neuropathological mechanism of AVH,providing evidence for the functional disconnection hypothesis of schizophrenia.
文摘The theorems for testing the local in one-port cellular neural/inear network (CNN) cells with four local state variables are presented. Using the theorems computes the bifurcation diagrams of the cardiac Purkinje fiber (CPE) equations Which describethe long-lasting action and pace-maker potentials of the Purkinje fiber of the heart. The computer simulation shows that periodic trajectories or convergent trajectories of the CPF Equations can be foun if the cormsponing cell Parameters are located in a positive domainbut nearby edge of chaos. In particular a heart with approximate normal frequency of heartbeat but non-normal electrocardiogram maysuddenly stop by slightly perturbing the parameters of the corresponding CPF Equations when the Paramders are located nearby the edge of chaos in the bifurcation diagrams. This research seems to interpret reasonbly the phenomena that patients with cardiac diseases might suddenly die without warning.
基金This project is jointly supported by the National Nature Science Foundation of China (Grant No. 60074034) and the Foundation for
文摘Presents analytic criteria for the local activity theory in two-port cellularneural network (CNN) cells with four local state variables, and gives the application to a smoothedChua's circuit (SCC) CNN with two-port and I 5 S 15 arrays. The bifurcation diagrams of the SCC CNNshow that they are completely the same as those of an SCC CNN with one-port calculated earlier;which do not exist locally passive domain. The evolution of the patterns of the state variables ofthe SCC CNN is stimulated. Oscillatory patterns, chaotic patterns, or divergent patterns may emergeif the selected cell parameters are located in the locally active unstable domains but nearby theedge of chaos domain.
基金the National Natural Science Foundation of China (Grant No. 60074034) and the Foundation forUniversity Key Teacher by the Ministry of Education of China.
文摘The analytic criteria for the local activity theory in one-port cellularneural network (CNN) with five local state variables are presented. The application to a Hyper-chaossynchronization Chua's circuit (HCSCC) CNN with 1125 variables is studied. The bifurcation diagramsof the HCSCC CNN show that they are slightly different from the smoothed CNN with one or two portsand four state variables calculated earlier. The evolution of the patterns of the state variables ofthe HCSCC CNN is stimulated. Oscillatory patterns, chaotic patterns, convergent or divergentpatterns may emerge if the selected cell parameters are located in the locally active domains butnearby or in the edge of chaos domain.
基金Project supported by the National Natural Science Foundation of China(Grant No.61771176)。
文摘Complexity and abundant dynamics may arise in locally-active systems only, in which locally-active elements are essential to amplify infinitesimal fluctuation signals and maintain oscillating. It has been recently found that some memristors may act as locally-active elements under suitable biasing. A number of important engineering applications would benefit from locally-active memristors. The aim of this paper is to show that locally-active memristor-based circuits can generate periodic and chaotic oscillations. To this end, we propose a non-volatile locally-active memristor, which has two asymptotically stable equilibrium points(or two non-volatile memristances) and globally-passive but locally-active characteristic. At an operating point in the locally-active region, a small-signal equivalent circuit is derived for describing the characteristics of the memristor near the operating point. By using the small-signal equivalent circuit, we show that the memristor possesses an edge of chaos in a voltage range, and that the memristor, when connected in series with an inductor,can oscillate about a locally-active operating point in the edge of chaos. And the oscillating frequency and the external inductance are determined by the small-signal admittance Y(iω). Furthermore, if the parasitic capacitor in parallel with the memristor is considered in the periodic oscillating circuit, the circuit generates chaotic oscillations.
基金National Nature Science Foundation of China(61872225)Natural Science Foundation of Shandong Province(ZR2020KF013,ZR2020ZD44,ZR2019ZD04,and ZR2020QF043)+1 种基金Introduction and Cultivation Program for Young Creative Talents in Colleges and Universities of Shandong Province(2019-173)Special Fund of Qilu Health and Health Leading Talents Training Project。
文摘Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-CA1),as well as to investigate the mechanism of acupuncture in the treatment of gynecological diseases.Methods Twenty-two healthy female subjects were stimulated by electroacupuncture at bilateral uterine acupoints;rs-f MRI data of the brain were acquired and standardized.Degree centrality(DC),amplitude of low-frequency fluctuation(ALFF),and regional homogeneity(ReHo)were used to analyze local spontaneous brain activity via acupuncture.An independent component analysis was used to evaluate the functional connectivity of the resting brain networks after acupuncture.Results Analytical results showed that the neural activity intensity of the precuneus lobe,orbitofrontal cortex,lingual gyrus,amygdala,and posterior central gyrus decreased after acupuncture(voxel P<0.001,cluster P<0.05).Functional connectivity analysis revealed weakened auditory and right frontal-parietal networks(voxel P<0.001,cluster P<0.05),enhanced visual network(voxel P<0.001,cluster P<0.05),and synergistic auditory network and hypothalamic-pituitary system.Conclusion Significant differences in neural activity and functional connectivity in specific brain regions were observed after acupuncture intervention at uterine acupoints;the hypothalamic-pituitary system also showed various active states in different brain regions.It is speculated that the effective mechanism of acupuncture at uterine acupoints is related to the regulation of reproductive hormones,emotional changes,and somatic sensations.Therefore,the methods used in this study could clarify the neural mechanism of uterine-point acupuncture in the treatment of gynecological diseases and may serve as a reference for other studies pertaining to acupuncture.
基金Project supported by the National Natural Science Foundation of China(Grant No.61773010)Taishan Scholar Foundation of Shandong Province of China(Grant No.ts20190938)。
文摘In order to make the peak and offset of the signal meet the requirements of artificial equipment,dynamical analysis and geometric control of the laser system have become indispensable.In this paper,a locally active memristor with non-volatile memory is introduced into a complex-valued Lorenz laser system.By using numerical measures,complex dynamical behaviors of the memristive laser system are uncovered.It appears the alternating appearance of quasi-periodic and chaotic oscillations.The mechanism of transformation from a quasi-periodic pattern to a chaotic one is revealed from the perspective of Hamilton energy.Interestingly,initial-values-oriented extreme multi-stability patterns are found,where the coexisting attractors have the same Lyapunov exponents.In addition,the introduction of a memristor greatly improves the complexity of the laser system.Moreover,to control the amplitude and offset of the chaotic signal,two kinds of geometric control methods including amplitude control and rotation control are designed.The results show that these two geometric control methods have revised the size and position of the chaotic signal without changing the chaotic dynamics.Finally,a digital hardware device is developed and the experiment outputs agree fairly well with those of the numerical simulations.
基金the Natural Science Foundation of Hunan Province, China (Grant Nos. 2022JJ30572, 2022JJ30160, and 2021JJ30671)the National Natural Science Foundations of China (Grant No. 62171401)the Key Project of Science and Technology of Shunde District (Grant No. 2130218002544)。
文摘At present, many neuron models have been proposed, which can be divided into discrete neuron models and continuous neuron models. Discrete neuron models have the advantage of faster simulation speed and the ease of understanding complex dynamic phenomena. Due to the properties of memorability, nonvolatility, and local activity, locally active discrete memristors(LADMs) are also suitable for simulating synapses. In this paper, we use an LADM to mimic synapses and establish a Rulkov neural network model. It is found that the change of coupling strength and the initial state of the LADM leads to multiple firing patterns of the neural network. In addition, considering the influence of neural network parameters and the initial state of the LADM, numerical analysis methods such as phase diagram and timing diagram are used to study the phase synchronization. As the system parameters and the initial states of the LADM change, the LADM coupled Rulkov neural network exhibits synchronization transition and synchronization coexistence.
基金the research“A Study on Foreign Students’Participation in Wenzhou Folk Activities and Their Culture Identity”(the Special Research Project of Zhejiang Foreign Languages Association,Project No.ZWYB 20211004.)。
文摘The number of foreign students studying in Wenzhou, China has increased dramatically as a result of the Belt and Road Initiative. Learning the motivations and leisure constraints of foreign students' participation in local cultural and folk activities in Wenzhou is beneficial to promoting cultural adaptation, strengthening Chinese cultural self-confidence, and improving Wenzhou's international image. Based on the hierarchical model of leisure constraints (personal constraints, interpersonal constraints, and structural constraints), this study has tended to focus on the leisure constraints for foreign students participating in local folk and cultural activities in Wenzhou. A total of seven participants were included in the analysis.
文摘By considering the heterogeneity of geomechanical materials, the source development of earthquake under compression boundary conditions is studied with a newly developed numerical method, Rock Failure Process Analysis code (RFPA2D). The process of fault forming and associated micro seismicities in a rectangle area with a inclusion but without any clear structural features of original fault is modeled. The modeling demonstrates the whole process of source development of earthquake from deformation, micro failure to collapse and the behavior of temporal spatial distribution of micro seismicities. The stress, strain and the temporal spatial distribution of micro seismicities vividly depict the phenomena of localization, temporal transitions, dilatation or rise, elastic rebound and conjugate (X type) deformation zone.
文摘The crystallization kinetics of Pd-Cu-Si glass was studied by means of diferential scanning calorimetry-Ⅱ.According to Kissinger peak shift methd and Arrhenius equation,the apparent activation energy was calculated.The crystallization kinetics follows Johnson- Mehl-Avrami equation with n=3.0 within 0.15<x<0.85.In isothermal treatment,the concepts of local Avrami exponent and local activation energy have been introduced into Pd-Cu-Si system for understanding the isothermal crystallization process.
文摘By precisely controlling both active sites and their surrounding microenvironments,enzymes catalyze complex transformations with remarkable efficiency and selectivity.This intricate interplay of structure and function in natural enzymes has inspired the emerging field of precision catalysis,which seeks to similarly modify active site architecture and local environments to enhance catalytic activity and selectivity in nonenzymaticsystems.Precision catalysis aims to enhance activity and selectivity,rivaling natural enzymes while achieving greater atom economy in catalyst design.Among various material platforms,metal-organic frame-works(MOFs)are uniquely positioned to advance precision catalysis due to their modular construction,structural regularity,and synthetic tunability.MOFs are porous crystalline molecular materials built from metal clusters and organic linkers.Their reticular nature enables the rational synthesis of hundreds of thousands of MOFs with diverse topologies and compositions.2 Unlike conventional homogeneous or heterogeneous catalysts,MOFs allow for atomic-level spatial control over the placement of catalytic sites.
基金financial support from NIH 5R01GM130772R.Ken Coit College of PharmacyArizona Center for Drug Discovery at the University of Arizona,USA。
文摘The current targeting drug delivery mainly relies on cancer cell surface receptors.However,in many cases,binding affinities between protein receptors and homing ligands is relatively low and the expression level between cancer and normal cells is not significant.Distinct from conventional targeting strategies,we have developed a general cancer targeting platform by building artificial receptor on cancer cell surface via a chemical remodeling of cell surface glycans.A new tetrazine(Tz)functionalized chemical receptor has been designed and efficiently installed on cancer cell surface as“overexpressed”biomarker through a metabolic glycan engineering.Different from the reported bioconjugation for drug targeting,the tetrazine labeled cancer cells not only locally activate TCO-caged prodrugs but also release active drugs via the unique bioorthogonal Tz-TCO click-release reaction.The studies have demonstrated that the new drug targeting strategy enables local activation of prodrug,which ultimately leads to effective and safe cancer therapy.
文摘Can WiFi signals be used for sensing purpose？ The growing PHY layer capabilities of WiFi has made it possible to reuse WiFi signals for both communication and sensing. Sensing via WiFi would enable remote sensing without wearable sensors, simultaneous perception and data transmission without extra communication infrastructure, and contactless sensing in privacy-preserving mode. Due to the popularity of WiFi devices and the ubiquitous deployment of WiFi networks, WiFi-based sensing networks, if fully connected, would potentially rank as one of the world＇s largest wireless sensor networks. Yet the concept of wireless and sensorless sensing is not the simple combination of WiFi and radar. It seeks breakthroughs from dedicated radar systems, and aims to balance between low cost and high accuracy, to meet the rising demand for pervasive environment perception in everyday life. Despite increasing research interest, wireless sensing is still in its infancy. Through introductions on basic principles and working prototypes, we review the feasibilities and limitations of wireless, sensorless, and contactless sensing via WiFi. We envision this article as a brief primer on wireless sensing for interested readers to explore this open and largely unexplored field and create next-generation wireless and mobile computing applications.
文摘Although presurgical evaluation of patients with pharamacoresistent focal epilepsies provides essential information for successful epilepsy surgery,there is still a need for further improvement.Developments of noninvasive electrophysiological recording and analysis techniques offer additional information based on interictal and ictal epileptic activities.In this review,we provide an overview on the application of ictal magnetoencephalography(MEG).The results of a literature research for published interictal/ictal MEG findings and experiences with own cases are demonstrated and discussed.Ictal MEG may provide added value in comparison to interictal recordings.The results may be more focal and closer to the invasively determined seizure onset zone.In some patients without clear interictal findings,ictal MEG could provide correct localization.Novel recording and analysis techniques facilitate ictal recordings.However,extended recording durations,movement and artifacts still represent practical limitations.Ictal MEG may provide added value regarding the localization of the seizure onset zone but depends on the selection of patients and the application of optimal analysis techniques.
基金supported by the Science and Technology Support Program of Sichuan Province(2018JY0562)the National Natural Science Foundation of China(81722050,81973962 and U1808204)the Key Project of Research and Development of Ministry of Science and Technology(2018AAA0100705).
文摘Background:The pathogenesis of neck pain in the brain,which is the fourth most common cause of disability,remains unclear.Furthermore,little is known about the characteristics of dynamic local functional brain activity in cervical pain.Objective:The present study aimed to investigate the changes of local brain activity caused by chronic neck pain and the factors leading to neck pain.Methods:Using the amplitude of low-frequency fluctuations(ALFF)method combined with sliding window approach,we compared local brain activity that was measured by the functional magnetic resonance imaging(fMRI)of 107 patients with chronic neck pain(CNP)with that of 57 healthy control participants.Five pathogenic factors were selected for correlation analysis.Results:The group comparison results of dynamic amplitude of low-frequency fluctuation(dALFF)variability showed that patients with CNP exhibited decreased dALFF variability in the left inferior temporal gyrus,the middle temporal gyrus,the angular gyrus,the inferior parietal marginal angular gyrus,and the middle occipital gyrus.The abnormal dALFF variability of the left inferior temporal gyrus was negatively correlated with the average daily working hours of patients with neck pain.Conclusions:The findings indicated that the brain regions of patients with CNP responsible for audition,vision,memory,and emotion were subjected to temporal variability of abnormal regional brain activity.Moreover,the dALFF variability in the left inferior temporal gyrus might be a risk factor for neck pain.This study revealed the brain dysfunction of patients with CNP from the perspective of dynamic local brain activity,and highlighted the important role of dALFF variability in understanding the neural mechanism of CNP.
