More than 200 years after Parkinson's disease was first described by the English surgeon whose name would eventually be given to the condition,available treatments remain purely symptomatic,leaving a critical unme...More than 200 years after Parkinson's disease was first described by the English surgeon whose name would eventually be given to the condition,available treatments remain purely symptomatic,leaving a critical unmet clinical need for a diseasemodifying therapy.展开更多
Laterally loaded piles,which are commonly used in sandy stratum foundations,are particularly susceptible to necking defects during cast-in-place installation due to borehole collapse risks.These construction-induced g...Laterally loaded piles,which are commonly used in sandy stratum foundations,are particularly susceptible to necking defects during cast-in-place installation due to borehole collapse risks.These construction-induced geometric imperfections substantially compromise pile safety under lateral loading conditions.To address this critical design challenge,we develop a reliability-based multi-objective optimization framework that simultaneously accounts for structural safety,construction economy,and design robustness.The proposed methodology integrates the p-y curve(where p is the soil pressure per unit length,and y is the lateral deflection of the pile)analysis with stochastic modeling,enabling efficient evaluation of pile performance considering uncertainties in soil parameters and depth and size variations of necking defects.A systematic design framework is implemented and validated through experimental case studies,successfully generating optimal designs along the Pareto front.The identified knee-point configurations serve as practical compromise solutions for engineering decisions.Parametric investigations further elucidate the influence of necking defect depth and sand friction angle variations on optimal design outcomes,offering insights into risk mitigation for pile construction.展开更多
Tooth cracks may occur in spiral bevel gear transmission system of the aerospace equipment.In this study,an accurate and efficient loaded tooth contact analysis(LTCA)model is developed to predict the contact behavior ...Tooth cracks may occur in spiral bevel gear transmission system of the aerospace equipment.In this study,an accurate and efficient loaded tooth contact analysis(LTCA)model is developed to predict the contact behavior and time-varying meshing stiffness(TVMS)of spiral bevel gear pair with cracked tooth.The tooth is sliced,and the contact points on slices are computed using roll angle surfaces.Considering the geometric complexity of crack surface,a set of procedures is formulated to generate spatial crack and determine crack parameters for contact points.According to the positional relationship between contact point and crack path,each sliced tooth is modeled as a non-uniform cantilever beam with varying reduced effective load-bearing tooth thickness.Then the compliance model of the cracked tooth is established to perform contact analysis,along with TVMS calculations utilizing three different models.By employing spiral bevel gear pairs with distinct types of cracks as examples,the accuracy and efficiency of the developed approach are validated via comparative analyses with finite element analysis(FEA)outcomes.Furthermore,the investigation on effects of cracks shows that tooth cracks can induce alterations in meshing performance of both entire gear pair and individual tooth pairs,including not only cracked tooth pair but also adjacent non-cracked tooth pairs.Hence,the proposed model can serve as a useful tool for analyzing the variations in contact behavior and meshing stiffness of spiral bevel gears due to different cracks.展开更多
Skin sensitization is a common adverse effect of a wide range of small reactive chemicals,leading to allergic contact dermatitis(ACD),the most frequent manifestation of immunotoxicity in humans.The prevalence of ACD i...Skin sensitization is a common adverse effect of a wide range of small reactive chemicals,leading to allergic contact dermatitis(ACD),the most frequent manifestation of immunotoxicity in humans.The prevalence of ACD is increasing,affecting up to 20%of the Western European population.This trend was particularly pronounced in high-risk occupational sectors,including healthcare,food services,metal and construction workers,and hairdressers[1].The skin sensitization adverse outcome pathway(AOP)comprises 11 elements,with four designated key events(KEs):formation of proteinhapten complexes(KE-1),inflammatory keratinocyte response(KE-2),dendritic cell(DC)activation(KE-3),and T-cell proliferation(KE-4)[2].As there is no cure for ACD,preventive strategies are of great relevance.In addition to avoiding exposure,preventive measures,such as the use of latex gloves,barrier creams,emollients,and moisturizers,often have limited effectiveness[3].展开更多
Clay deposits typically exhibit significant degrees of heterogeneity and anisotropy in their strength and stiffness properties.Such non-monotonic responses can significantly impact the stability analysis and design of...Clay deposits typically exhibit significant degrees of heterogeneity and anisotropy in their strength and stiffness properties.Such non-monotonic responses can significantly impact the stability analysis and design of overlying shallow foundations.In this study,the undrained bearing capacity of shallow foundations resting on inhomogeneous and anisotropic clay layers subjected to oblique-eccentric combined loading is investigated through a comprehensive series of finite element limit analysis(FELA)based on the well-established lower-bound theorem and second-order cone programming(SOCP).The heterogeneity of normally consolidated(NC)clays is simulated by adopting a well-known general model of undrained shear strength increasing linearly with depth.In contrast,for overconsolidated(OC)clays,the variation of undrained shear strength with depth is considered to follow a bilinear trend.Furthermore,the inherent anisotropy is accounted for by adopting different values of undrained shear strength along different directions within the soil medium,employing an iterative-based algorithm.The results of numerical simulations are utilized to investigate the influences of natural soil heterogeneity and inherent anisotropy on the ultimate bearing capacity,failure envelope,and failure mechanism of shallow foundations subjected to the various combinations of vertical-horizontal(V-H)and vertical-moment(V-M)loads.展开更多
A coal-loaded charge induction monitoring system is developed to effectively forecast the dynamic disasters caused by coal failure.Specifically,a digital finite impulse response(FIR)filter is designed to denoise and f...A coal-loaded charge induction monitoring system is developed to effectively forecast the dynamic disasters caused by coal failure.Specifically,a digital finite impulse response(FIR)filter is designed to denoise and filter the signal,and the time-frequency domain evolution of induced charge signals is analyzed during coal failure experiments.The quantitative relationships between the induced electric charge and stress-strain energy,and ultimately,between induced electric charge and coal deformation/failure,are revealed.Ultimately,the electric charge sensor exhibits high signal collection frequency and high sensitivity,and the FIR low-pass filter constructed in MATLAB effectively denoises and filters induced charge signals.The main frequency range of the white noise is 50-500 Hz,and the main frequency of the charge signal induced by coal deformation and failure is concentrated in the range of 0-50 Hz.The optimal distances for monitoring cubic and cylindrical raw coal samples using this sensor are 9 mm and 11 mm,respectively.Notably,strain energy is released faster when it can dissipate more readily,and induced charge pulses become denser when more intense signals produce large fluctuations.A method is proposed to identify coal deformation and failure based on changes in the induced electric charge.This study provides a new means of monitoring the early warning signs of dynamic coal mine disasters.Based on our experimental results and conclusions,a new method is proposed to identify coal deformation and failure based on changes in the induced electric charge.The precursor to the moment of coal failure can be identified by monitoring the amplitude of the induced charge,the dynamic trend of fluctuation,and the cumulative number of induced electric charge pulses during the process of coal deformation.展开更多
Borehole pressure relief helps prevent rock bursts.However,this may change the physical and mechan-ical properties of the surrounding rock,affect the variation of the plastic zone of the roadway,and lead to the failur...Borehole pressure relief helps prevent rock bursts.However,this may change the physical and mechan-ical properties of the surrounding rock,affect the variation of the plastic zone of the roadway,and lead to the failure of roadway support,thus threatening the safety of the roadway.In this paper,the variable angle shear test of drilled specimens under the action of static and dynamic loads is used to study the evolution of mechanical parameters of the specimens and their influence on the plastic zone of the sur-rounding rock.The shear strength decreases linearly with the increase of drilling diameter.With the increase of pre-static load level and dynamic load amplitude,the cohesion first increases and then decreases,and the internal friction angle decreases.Moreover,the shear failure surface changes from rough to smooth.The reasons include that the static load enhances the tooth cutting effect and the repeated friction of cracks caused by the dynamic load.Borehole pressure relief leads to an increase in the radius of the plastic zone of the surrounding rock following a quadratic function.The research results of this paper provide a theoretical basis for designing drilling unloading parameters and supporting parameters for rock burst roadways.展开更多
Metal(oxide)-zeolite bifunctional catalysts have been the subject of considerable attention from researchers in both academic and industry,due to their superior activity and stability in various heterogeneous catalyti...Metal(oxide)-zeolite bifunctional catalysts have been the subject of considerable attention from researchers in both academic and industry,due to their superior activity and stability in various heterogeneous catalytic processes[1–3].Based on the different metal loading sites,these bifunctional catalysts can be categorized as follows:(a)metal species loaded on the outer surface of zeolite crystals,(b)metal species encapsulated within the channels or cavities of zeolites,and(c)metal species incorporated into the zeolite framework(Fig.1).Metal species in type(b)and(c)samples are stabilized by the zeolite frameworks,resulting in excellent thermal and hydrothermal stability during catalytic reactions,especially under harsh conditions,as well as unique shape-selectivity.However,the complex synthesis procedures make large-scale preparation of these catalysts impractical.In contrast,a type(a)sample can be achieved via the simple impregnation;nevertheless,migration of metal species and their aggregation into larger particles often occur during the calcination and reduction processes.展开更多
This article experimentally studies the effects of air injection near the blade trailing edge on flow separation and losses in a highly loaded linear compressor cascade. Aerodynamic parameters of eight cascades with d...This article experimentally studies the effects of air injection near the blade trailing edge on flow separation and losses in a highly loaded linear compressor cascade. Aerodynamic parameters of eight cascades with different air injection slot configura- tions are measured by using a five-hole probe at the cascade outlets. Ink-trace flow visualization is performed to obtain the flow details around the air injection slots. The static pressure distribution is clarified with pressure taps on the endwalls. The...展开更多
There is still no effective therapy for muscle atrophy.It found that miR-194 was significantlydownregulated in muscle atrophy model.miR-194 could promote muscle differentiation,and also inhibit ubiquitin ligases.miR-1...There is still no effective therapy for muscle atrophy.It found that miR-194 was significantlydownregulated in muscle atrophy model.miR-194 could promote muscle differentiation,and also inhibit ubiquitin ligases.miR-194 loaded in gelatin nanosphere were injected into the muscle atrophy model to realize controlled release.展开更多
The stress minimization multi-material topology optimization(MMTO)approach has recently attracted significant attention because of its applications in aerospace and mechanical engineering.Nonetheless,the stress minimi...The stress minimization multi-material topology optimization(MMTO)approach has recently attracted significant attention because of its applications in aerospace and mechanical engineering.Nonetheless,the stress minimization MMTO approach may result in stress surpassing the material's tolerance limit,potentially culminating in failure.This research proposes a novel way for imposing stress constraints on each material to regulate their respective stress levels.The fundamental concept is that each material possesses its own interpolation function for the stress model.The maximum von Mises stress for each material can be established with the definition of an upper limit,ensuring that the materials will perform safely and effectively.This aids topological structures in resisting failure and augmenting strength.A multi-physics system including thermoelastic and self-weight loads is concurrently examined alongside stress limitations.The global stress constraint utilizes the p-norm function,and the adjoint method is used to derive sensitivity.This work employs a three-field strategy utilizing density filtering and Heaviside projection functions to mitigate the artificial stress in low density.The technique is assessed through two-dimensional(2D)and three-dimensional(3D)examples,illustrating the influence of stress limits on the compliance minimization under heat and self-weight loads.The optimized results indicate a substantial decrease in the stress levels accompanied by a minor gain in compliance,while maintaining the stress within the specified range for all materials.展开更多
LEO satellite communication systems have the characteristics of high-speed and periodic movement.The handover of user link occurs frequently,which has a serious impact on user terminal application and system capacity....LEO satellite communication systems have the characteristics of high-speed and periodic movement.The handover of user link occurs frequently,which has a serious impact on user terminal application and system capacity.To address this issue,we propose a handover strategy of LEO satellite user terminal based on multi-attribute and multi-point(MAMP)cooperation.Firstly,the satellite-user-time matrix is established by using the satellite constellation coverage and handover model.Then,combined with the visual time and signal quality,the user access matrix and satellite load matrix are extracted to determine the weight equation of the handover strategy with the channel reservation.According to the system modeling simulation,the algorithm improves the handover success rate by 2.5%,the lasted call access success rate by 3.2%,the load balancing degree by 20%,and the robustness by two orders of magnitude.展开更多
The contact deformation and buckling of elastic rods against rigid surfaces represent a prevalent phenomenon in applications such as oil drilling,arterial stents,and energy harvesting.This has attracted widespread att...The contact deformation and buckling of elastic rods against rigid surfaces represent a prevalent phenomenon in applications such as oil drilling,arterial stents,and energy harvesting.This has attracted widespread attention from researchers.In this paper,the deformation and buckling behaviors of a circular arch subject to compression by a rigid plate are investigated with a planar elastic rod model that incorporates tension,shearing,and bending.In comparison with the existing models that solely consider the bending energy,the deflection curve,the internal force distribution,and the critical load of the present model show good agreement with the finite element results.Through the dimensional analysis and order-of-magnitude estimation,we examine the factors influencing the critical load.The study reveals that the semi-central angle of the arch has the most significant effect.The dimensionless geometric parameter describing arch slenderness becomes prominent when the semi-central angle is less than 30°,while Poisson's ratio and the cross-sectional shear correction factor exhibit negligible influence.Furthermore,the variation in the proportions of strain energy components during critical buckling is presented with respect to the semi-central angle and the geometric parameter,thereby delineating the applicable ranges of both the original model(OM)and the modified model(MM).展开更多
Invasive pests and pathogens cause immense damage globally,costing an estimated US$248 billion to the agricultural industry alone.Vehicles,such as farming and timber harvesting machinery and transportation trucks,can ...Invasive pests and pathogens cause immense damage globally,costing an estimated US$248 billion to the agricultural industry alone.Vehicles,such as farming and timber harvesting machinery and transportation trucks,can facilitate the rapid spread of biological invaders over distances far greater and more quickly than their natural dispersal ability.Understanding how frequent trips by these vehicles increase the spread of invasive agricultural and forestry pests can help inform effective biosecurity procedures before,during,or after an incursion.We used a case study of timber transport trucks in Aotearoa New Zealand to examine whether and how vehicles facilitate the spread of soil-borne pathogens between commercial forest plantations.Our results show that long-distance dispersal associated with truck movement facilitated the introduction of oomycete-like pathogens in 97% of forest sites within only one year,with pathogen loads within infected sites predicted at 84%of the sites’carrying capacity.Implementing preventative management strategies to reduce the transportation of infected soil by logging trucks,however,can reduce the spread by up to 50% after one year and reduce the pathogen load within infested sites by more than three times.Mitigating other human-assisted dispersal pathways can also help reduce spread.Reducing movement of forest visitors not involved in forestry activities,for instance,by closing forest sites to the public,can help to further reduce spread in addition to management related to harvesting activities.These results highlight the benefits of preventative management strategies in reducing the spread rate of novel soil pathogens through a high-intensity commercial forestry network but show that pest spread is still likely even with significant investment.展开更多
Drill string vibration during drilling plays a vital and potentially decisive role in maintaining wellbore stability,as repeated impacts may lead to fatigue and borehole collapse.While drilling through geological laye...Drill string vibration during drilling plays a vital and potentially decisive role in maintaining wellbore stability,as repeated impacts may lead to fatigue and borehole collapse.While drilling through geological layers,a material contrast may act as a localization point for wellbore damage.The hypothesis tested in this paper is that wellbore instability is focused on the boundary between the layers and that mechanical contrasts accelerate the wellbore collapse.In this study,an elastic-plastic damage model was employed to investigate the effects of repeated mechanical impacts on wellbore stability.A 2-dimensional(2D)model of a wellbore surrounded by contrasting materials was developed,and the accumulated damage caused by repeated lateral impacts was monitored.It was found that damage develops not only around the wall of the wellbore but also along the material boundaries.A sensitivity analysis was carried out to identify the impact of contrasts in both elastic(Young's modulus and Poisson's ratio)and plastic(cohesion,friction angle,and dilation angle)parameters between layers.Four damage patterns were identifiedin the simulated models.The results also suggested that the number of impacts required to reach the critical damage was highly affected by the contrast in elastic parameters,while cohesion and friction angle contrasts had a lesser effect.Additionally,increasing the contrast in the dilation angle localized the damage,thus reducing the number of impacts required to trigger wellbore failure.展开更多
Natural hybridization is known to play a vital role in speciation;however,the mechanisms underlying the early stages of natural hybridization remain unclear.Where two plant species come into contact,two driving forces...Natural hybridization is known to play a vital role in speciation;however,the mechanisms underlying the early stages of natural hybridization remain unclear.Where two plant species come into contact,two driving forces may balance the dynamic consequences of hybridization:fusion by hybridization-mediated gene flow,and separation by reproductive isolation(RI)(Ma et al.,2010a,b;Chang et al.,2022).展开更多
Studies of wave-current interactions are vital for the safe design of structures.Regular waves in the presence of uniform,linear shear,and quadratic shear currents are explored by the High-Level Green-Naghdi model in ...Studies of wave-current interactions are vital for the safe design of structures.Regular waves in the presence of uniform,linear shear,and quadratic shear currents are explored by the High-Level Green-Naghdi model in this paper.The five-point central difference method is used for spatial discretization,and the fourth-order Adams predictor-corrector scheme is employed for marching in time.The domain-decomposition method is applied for the wave-current generation and absorption.The effects of currents on the wave profile and velocity field are examined under two conditions:the same velocity of currents at the still-water level and the constant flow volume of currents.Wave profiles and velocity fields demonstrate substantial differences in three types of currents owing to the diverse vertical distribution of current velocity and vorticity.Then,loads on small-scale vertical cylinders subjected to regular waves and three types of background currents with the same flow volume are investigated.The maximum load intensity and load fluctuation amplitude in uniform,linear shear,and quadratic shear currents increase sequentially.The stretched superposition method overestimates the maximum load intensity and load fluctuation amplitude in opposing currents and underestimates these values in following currents.The stretched superposition method obtains a poor approximation for strong nonlinear waves,particularly in the case of the opposing quadratic shear current.展开更多
Based on the split hopkinson pressure bar(SHPB)tests results,the cubic specimens have been numerically modeled in this paper to investigate the impact of key factors,such as the rise time,duration,and incident pulse s...Based on the split hopkinson pressure bar(SHPB)tests results,the cubic specimens have been numerically modeled in this paper to investigate the impact of key factors,such as the rise time,duration,and incident pulse shape,on achieving stress uniformity.After analysis,the paper provides actionable methods aimed at optimizing the conditions for stress uniformity within the cubic specimen.Finally,the lateral inertia effect of cubic specimen has been scrutinized to address the existing gap in this academic area.展开更多
Freeze-thaw(F-T)cycle is receiving increasing attention as a primary threat to the long-term stability of rock engineering in high-elevation regions.In this study,artificial F-T cycle tests are first conducted on pre-...Freeze-thaw(F-T)cycle is receiving increasing attention as a primary threat to the long-term stability of rock engineering in high-elevation regions.In this study,artificial F-T cycle tests are first conducted on pre-flawed sandstone specimens with real-time frost heave pressure(FHP)monitoring,followed by subsequent cyclic loading tests with different maximum stresses.Given the water-ice-sandstone interaction,the evolution process of FHP in flaws can be divided into six phases,i.e.initial,silence,eruption,reduction,second-arising,and dissipation phases.Its magnitude exhibits an exponential decrease with increasing F-T cycle number.The influences of F-T cycles and the maximum stress on the fatigue mechanical characteristics of flawed sandstone are revealed.Subjected to higher F-T cycles and maximum stress,larger irreversible strain and less dissipated energy are accumulated inside flawed sandstone specimens,leading to faster damage and lower fatigue life.The three-stage evolution characters of irreversible strain and dissipated energy are both weakened by repeated F-T treatment,i.e.the prolonged initial and accelerated stages and shortened stable stage.In addition,the repeated F-T cycles diminish the impact of prefabricated flaws on cracking behavior of flawed sandstone specimens,and the fatigue failure pattern changes from shear-dominated failure with a transfixion shear band to tensile-dominated failure with massive tensile cracks as the F-T cycle number increases.Employing the scanning electron microscopy(SEM),the underlying damage mechanisms of flawed rocks under the coupling effect of F-T treatment and cyclic loading are discussed.Finally,an F-T-fatigue damage model is proposed based on FHP evolution and irreversible strain,which possesses distinct physical significance and reasonably quantifies the F-T deterioration and fatigue damage accumulation of flawed rocks.展开更多
Large-scale geological energy storage plays a crucial role in balancing the intermittency of renewable energy.As an energy storage medium,soaked sandstone has a wide range of applications in geological energy storage....Large-scale geological energy storage plays a crucial role in balancing the intermittency of renewable energy.As an energy storage medium,soaked sandstone has a wide range of applications in geological energy storage.Understanding the damage characteristics in soaked sandstones is essential for ensuring the stability and longevity of these energy storage systems.This study involved multi-stage cyclic loading tests conducted on soaked sandstone to explore the damage evolution throughout the loading process.The findingsreveal several important insights:(1)The plastic hysteresis loops observed during multi-stage cyclic loading evolved from dense to sparse.An increase in stress level led to greater damage in the rock,as evidenced by an increase in accumulated peak/plastic strains.(2)Energy density and stress level are related by quadratic polynomial relationships.The elastic and dissipated energy densities are related by a linear law.The average energy storage coefficientdecreased by up to 24.1%with increasing stress amplitude,reflectingchanges in energy dynamics within the samples.(3)AE counts,amplitude,and frequency provided critical insights into rock damage and fracture patterns.The greater the loading rate and stress amplitude,the lower the proportion of high-amplitude,high-peak frequency,and shear-type fractures.Increasing stress amplitude caused a maximum 16.63%reduction in the AE bvalue,indicating shifts in fracture behavior under varying stress conditions.(4)The increase in loading rate and stress amplitude promotes the transformation of micropores and mesopores to macropores/microcracks.(5)Damage variables,definedin terms of cumulative dissipation energy,aligned closely with the fatigue damage model under multi-stage cyclic loading.Accelerated damage primarily occurred during the finalstages of fatigue loading,highlighting critical periods in the degradation of soaked sandstones.This study can offer guidance for designing operational parameters for energy storage geological bodies dominated by soaked sandstones.展开更多
基金funded by The Michael J.Fox Foundation for Parkinson’s Research(grant numbers:17244 and 023410)Science Foundation Ireland(grant number:19/FFP/6554)(to ED)。
文摘More than 200 years after Parkinson's disease was first described by the English surgeon whose name would eventually be given to the condition,available treatments remain purely symptomatic,leaving a critical unmet clinical need for a diseasemodifying therapy.
基金supported by the Fundamental Research Funds for the Central Universities of China(No.226-2024-00197)the National Natural Science Foundation of China(No.42277129)+1 种基金the Key R&D Project of Zhejiang Province(No.2021C03159)the Natural Science Foundation of Zhejiang Province(No.LR24E080004),China.
文摘Laterally loaded piles,which are commonly used in sandy stratum foundations,are particularly susceptible to necking defects during cast-in-place installation due to borehole collapse risks.These construction-induced geometric imperfections substantially compromise pile safety under lateral loading conditions.To address this critical design challenge,we develop a reliability-based multi-objective optimization framework that simultaneously accounts for structural safety,construction economy,and design robustness.The proposed methodology integrates the p-y curve(where p is the soil pressure per unit length,and y is the lateral deflection of the pile)analysis with stochastic modeling,enabling efficient evaluation of pile performance considering uncertainties in soil parameters and depth and size variations of necking defects.A systematic design framework is implemented and validated through experimental case studies,successfully generating optimal designs along the Pareto front.The identified knee-point configurations serve as practical compromise solutions for engineering decisions.Parametric investigations further elucidate the influence of necking defect depth and sand friction angle variations on optimal design outcomes,offering insights into risk mitigation for pile construction.
基金co-supported by the National Natural Science Foundation of China (No. 52175104)the Postdoctoral Fellowship Program of CPSF (No. GZC20233008)
文摘Tooth cracks may occur in spiral bevel gear transmission system of the aerospace equipment.In this study,an accurate and efficient loaded tooth contact analysis(LTCA)model is developed to predict the contact behavior and time-varying meshing stiffness(TVMS)of spiral bevel gear pair with cracked tooth.The tooth is sliced,and the contact points on slices are computed using roll angle surfaces.Considering the geometric complexity of crack surface,a set of procedures is formulated to generate spatial crack and determine crack parameters for contact points.According to the positional relationship between contact point and crack path,each sliced tooth is modeled as a non-uniform cantilever beam with varying reduced effective load-bearing tooth thickness.Then the compliance model of the cracked tooth is established to perform contact analysis,along with TVMS calculations utilizing three different models.By employing spiral bevel gear pairs with distinct types of cracks as examples,the accuracy and efficiency of the developed approach are validated via comparative analyses with finite element analysis(FEA)outcomes.Furthermore,the investigation on effects of cracks shows that tooth cracks can induce alterations in meshing performance of both entire gear pair and individual tooth pairs,including not only cracked tooth pair but also adjacent non-cracked tooth pairs.Hence,the proposed model can serve as a useful tool for analyzing the variations in contact behavior and meshing stiffness of spiral bevel gears due to different cracks.
基金support was provided by the European Regional Development Fund(ERDF),through the Centro 2020 Regional Operational Programme,Portugal(Project No.:CENTRO-01-0145-FEDER-000012(HealthyAging2020))through the COMPETE 2020-Operational Programme for Competitiveness and Internationalisation and Portuguese National Funds via Fundaçao para a Ciencia e a Tecnologia,Portugal(Project Nos.:POCI-01-0145-FEDER-029369 UIDB/04539/2020,iBiMED UIDB/04501/2020,DOI identifier https://doi.org/10.54499/UIDB/04501/2020 and project reference UIDP/04501/2020,DOI identifier https://doi.org/10.54499/UIDP/04501/2020,and LA/P/0058/2020)supported by Fundaçao para a Ciencia e a Tecnologia through the individual PhD fellowships,Portugal(Grant Nos.:PD/BDE/142926/2018 and SFRH/BD/110717/2015)。
文摘Skin sensitization is a common adverse effect of a wide range of small reactive chemicals,leading to allergic contact dermatitis(ACD),the most frequent manifestation of immunotoxicity in humans.The prevalence of ACD is increasing,affecting up to 20%of the Western European population.This trend was particularly pronounced in high-risk occupational sectors,including healthcare,food services,metal and construction workers,and hairdressers[1].The skin sensitization adverse outcome pathway(AOP)comprises 11 elements,with four designated key events(KEs):formation of proteinhapten complexes(KE-1),inflammatory keratinocyte response(KE-2),dendritic cell(DC)activation(KE-3),and T-cell proliferation(KE-4)[2].As there is no cure for ACD,preventive strategies are of great relevance.In addition to avoiding exposure,preventive measures,such as the use of latex gloves,barrier creams,emollients,and moisturizers,often have limited effectiveness[3].
文摘Clay deposits typically exhibit significant degrees of heterogeneity and anisotropy in their strength and stiffness properties.Such non-monotonic responses can significantly impact the stability analysis and design of overlying shallow foundations.In this study,the undrained bearing capacity of shallow foundations resting on inhomogeneous and anisotropic clay layers subjected to oblique-eccentric combined loading is investigated through a comprehensive series of finite element limit analysis(FELA)based on the well-established lower-bound theorem and second-order cone programming(SOCP).The heterogeneity of normally consolidated(NC)clays is simulated by adopting a well-known general model of undrained shear strength increasing linearly with depth.In contrast,for overconsolidated(OC)clays,the variation of undrained shear strength with depth is considered to follow a bilinear trend.Furthermore,the inherent anisotropy is accounted for by adopting different values of undrained shear strength along different directions within the soil medium,employing an iterative-based algorithm.The results of numerical simulations are utilized to investigate the influences of natural soil heterogeneity and inherent anisotropy on the ultimate bearing capacity,failure envelope,and failure mechanism of shallow foundations subjected to the various combinations of vertical-horizontal(V-H)and vertical-moment(V-M)loads.
基金supported by the National Key Research and Development Project of the National Natural Science Foundation(Grant No.2022YFC3004605)the National Natural Science Foundation of China Youth Science Fund(Grant No.52104087).
文摘A coal-loaded charge induction monitoring system is developed to effectively forecast the dynamic disasters caused by coal failure.Specifically,a digital finite impulse response(FIR)filter is designed to denoise and filter the signal,and the time-frequency domain evolution of induced charge signals is analyzed during coal failure experiments.The quantitative relationships between the induced electric charge and stress-strain energy,and ultimately,between induced electric charge and coal deformation/failure,are revealed.Ultimately,the electric charge sensor exhibits high signal collection frequency and high sensitivity,and the FIR low-pass filter constructed in MATLAB effectively denoises and filters induced charge signals.The main frequency range of the white noise is 50-500 Hz,and the main frequency of the charge signal induced by coal deformation and failure is concentrated in the range of 0-50 Hz.The optimal distances for monitoring cubic and cylindrical raw coal samples using this sensor are 9 mm and 11 mm,respectively.Notably,strain energy is released faster when it can dissipate more readily,and induced charge pulses become denser when more intense signals produce large fluctuations.A method is proposed to identify coal deformation and failure based on changes in the induced electric charge.This study provides a new means of monitoring the early warning signs of dynamic coal mine disasters.Based on our experimental results and conclusions,a new method is proposed to identify coal deformation and failure based on changes in the induced electric charge.The precursor to the moment of coal failure can be identified by monitoring the amplitude of the induced charge,the dynamic trend of fluctuation,and the cumulative number of induced electric charge pulses during the process of coal deformation.
基金supported by the National Natural Science Foundation of China(Nos.52374100,52525401,and 52304150)Outstanding Young Talent Project of Shanxi Province(No.SJYC2024301)Research Project Supported by Shanxi Scholarship Council of China(No.2023-041).
文摘Borehole pressure relief helps prevent rock bursts.However,this may change the physical and mechan-ical properties of the surrounding rock,affect the variation of the plastic zone of the roadway,and lead to the failure of roadway support,thus threatening the safety of the roadway.In this paper,the variable angle shear test of drilled specimens under the action of static and dynamic loads is used to study the evolution of mechanical parameters of the specimens and their influence on the plastic zone of the sur-rounding rock.The shear strength decreases linearly with the increase of drilling diameter.With the increase of pre-static load level and dynamic load amplitude,the cohesion first increases and then decreases,and the internal friction angle decreases.Moreover,the shear failure surface changes from rough to smooth.The reasons include that the static load enhances the tooth cutting effect and the repeated friction of cracks caused by the dynamic load.Borehole pressure relief leads to an increase in the radius of the plastic zone of the surrounding rock following a quadratic function.The research results of this paper provide a theoretical basis for designing drilling unloading parameters and supporting parameters for rock burst roadways.
基金financially supported by the National Key R&D Program of China(2024YFE0101100)the National Natural Science Foundation of China(22475112,22305132,22305155)+1 种基金the China Postdoctoral Science Foundation(2023M732323)the Postdoctoral Fellowship Program of CPSF(GZC20231679).
文摘Metal(oxide)-zeolite bifunctional catalysts have been the subject of considerable attention from researchers in both academic and industry,due to their superior activity and stability in various heterogeneous catalytic processes[1–3].Based on the different metal loading sites,these bifunctional catalysts can be categorized as follows:(a)metal species loaded on the outer surface of zeolite crystals,(b)metal species encapsulated within the channels or cavities of zeolites,and(c)metal species incorporated into the zeolite framework(Fig.1).Metal species in type(b)and(c)samples are stabilized by the zeolite frameworks,resulting in excellent thermal and hydrothermal stability during catalytic reactions,especially under harsh conditions,as well as unique shape-selectivity.However,the complex synthesis procedures make large-scale preparation of these catalysts impractical.In contrast,a type(a)sample can be achieved via the simple impregnation;nevertheless,migration of metal species and their aggregation into larger particles often occur during the calcination and reduction processes.
基金National Natural Science Foundation of China (50876023)Chinese Specialized Research Fund for the Doctoral Pro-gram of Higher Education (20060213007)National Basic Research Program of China (2007CB210100)
文摘This article experimentally studies the effects of air injection near the blade trailing edge on flow separation and losses in a highly loaded linear compressor cascade. Aerodynamic parameters of eight cascades with different air injection slot configura- tions are measured by using a five-hole probe at the cascade outlets. Ink-trace flow visualization is performed to obtain the flow details around the air injection slots. The static pressure distribution is clarified with pressure taps on the endwalls. The...
文摘There is still no effective therapy for muscle atrophy.It found that miR-194 was significantlydownregulated in muscle atrophy model.miR-194 could promote muscle differentiation,and also inhibit ubiquitin ligases.miR-194 loaded in gelatin nanosphere were injected into the muscle atrophy model to realize controlled release.
基金Project supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.RS-2025-02303676)。
文摘The stress minimization multi-material topology optimization(MMTO)approach has recently attracted significant attention because of its applications in aerospace and mechanical engineering.Nonetheless,the stress minimization MMTO approach may result in stress surpassing the material's tolerance limit,potentially culminating in failure.This research proposes a novel way for imposing stress constraints on each material to regulate their respective stress levels.The fundamental concept is that each material possesses its own interpolation function for the stress model.The maximum von Mises stress for each material can be established with the definition of an upper limit,ensuring that the materials will perform safely and effectively.This aids topological structures in resisting failure and augmenting strength.A multi-physics system including thermoelastic and self-weight loads is concurrently examined alongside stress limitations.The global stress constraint utilizes the p-norm function,and the adjoint method is used to derive sensitivity.This work employs a three-field strategy utilizing density filtering and Heaviside projection functions to mitigate the artificial stress in low density.The technique is assessed through two-dimensional(2D)and three-dimensional(3D)examples,illustrating the influence of stress limits on the compliance minimization under heat and self-weight loads.The optimized results indicate a substantial decrease in the stress levels accompanied by a minor gain in compliance,while maintaining the stress within the specified range for all materials.
基金supported by the Innovation Funding of ICT,CAS under Grant(No.E261020)Jiangsu Key Research and Development Program of China(No.BE2021013-2)Zhejiang Key Research and Development Program(No.2021C01040).
文摘LEO satellite communication systems have the characteristics of high-speed and periodic movement.The handover of user link occurs frequently,which has a serious impact on user terminal application and system capacity.To address this issue,we propose a handover strategy of LEO satellite user terminal based on multi-attribute and multi-point(MAMP)cooperation.Firstly,the satellite-user-time matrix is established by using the satellite constellation coverage and handover model.Then,combined with the visual time and signal quality,the user access matrix and satellite load matrix are extracted to determine the weight equation of the handover strategy with the channel reservation.According to the system modeling simulation,the algorithm improves the handover success rate by 2.5%,the lasted call access success rate by 3.2%,the load balancing degree by 20%,and the robustness by two orders of magnitude.
基金Project supported by the National Natural Science Foundation of China(Nos.124B2043,U2241267,12172155,and 12302278)the Science and Technology Leading Talent Project of Gansu Province of China(No.23ZDKA0009)the Natural Science Foundation of Gansu Province of China(Nos.24JRRA473 and 24JRRA489)。
文摘The contact deformation and buckling of elastic rods against rigid surfaces represent a prevalent phenomenon in applications such as oil drilling,arterial stents,and energy harvesting.This has attracted widespread attention from researchers.In this paper,the deformation and buckling behaviors of a circular arch subject to compression by a rigid plate are investigated with a planar elastic rod model that incorporates tension,shearing,and bending.In comparison with the existing models that solely consider the bending energy,the deflection curve,the internal force distribution,and the critical load of the present model show good agreement with the finite element results.Through the dimensional analysis and order-of-magnitude estimation,we examine the factors influencing the critical load.The study reveals that the semi-central angle of the arch has the most significant effect.The dimensionless geometric parameter describing arch slenderness becomes prominent when the semi-central angle is less than 30°,while Poisson's ratio and the cross-sectional shear correction factor exhibit negligible influence.Furthermore,the variation in the proportions of strain energy components during critical buckling is presented with respect to the semi-central angle and the geometric parameter,thereby delineating the applicable ranges of both the original model(OM)and the modified model(MM).
基金supported by the Forest Growers Levy Trust(QT-10353)the Ministry for Primary Industries and the Sustainable Food and Fibre Futures fund(SFFF22023)the Strategic Science Investment Fund(CO4X1703)for funding this research.
文摘Invasive pests and pathogens cause immense damage globally,costing an estimated US$248 billion to the agricultural industry alone.Vehicles,such as farming and timber harvesting machinery and transportation trucks,can facilitate the rapid spread of biological invaders over distances far greater and more quickly than their natural dispersal ability.Understanding how frequent trips by these vehicles increase the spread of invasive agricultural and forestry pests can help inform effective biosecurity procedures before,during,or after an incursion.We used a case study of timber transport trucks in Aotearoa New Zealand to examine whether and how vehicles facilitate the spread of soil-borne pathogens between commercial forest plantations.Our results show that long-distance dispersal associated with truck movement facilitated the introduction of oomycete-like pathogens in 97% of forest sites within only one year,with pathogen loads within infected sites predicted at 84%of the sites’carrying capacity.Implementing preventative management strategies to reduce the transportation of infected soil by logging trucks,however,can reduce the spread by up to 50% after one year and reduce the pathogen load within infested sites by more than three times.Mitigating other human-assisted dispersal pathways can also help reduce spread.Reducing movement of forest visitors not involved in forestry activities,for instance,by closing forest sites to the public,can help to further reduce spread in addition to management related to harvesting activities.These results highlight the benefits of preventative management strategies in reducing the spread rate of novel soil pathogens through a high-intensity commercial forestry network but show that pest spread is still likely even with significant investment.
基金support from the Research Council of Norway,Equinor,and Sekal with NFR project(Grant No.308826).
文摘Drill string vibration during drilling plays a vital and potentially decisive role in maintaining wellbore stability,as repeated impacts may lead to fatigue and borehole collapse.While drilling through geological layers,a material contrast may act as a localization point for wellbore damage.The hypothesis tested in this paper is that wellbore instability is focused on the boundary between the layers and that mechanical contrasts accelerate the wellbore collapse.In this study,an elastic-plastic damage model was employed to investigate the effects of repeated mechanical impacts on wellbore stability.A 2-dimensional(2D)model of a wellbore surrounded by contrasting materials was developed,and the accumulated damage caused by repeated lateral impacts was monitored.It was found that damage develops not only around the wall of the wellbore but also along the material boundaries.A sensitivity analysis was carried out to identify the impact of contrasts in both elastic(Young's modulus and Poisson's ratio)and plastic(cohesion,friction angle,and dilation angle)parameters between layers.Four damage patterns were identifiedin the simulated models.The results also suggested that the number of impacts required to reach the critical damage was highly affected by the contrast in elastic parameters,while cohesion and friction angle contrasts had a lesser effect.Additionally,increasing the contrast in the dilation angle localized the damage,thus reducing the number of impacts required to trigger wellbore failure.
基金supported by the National Natural Science Foundation of China(U23A20160,32360336)Guizhou Provincial Key Technology R&D Program(Qian KeHe ZhiCheng[2023]YiBan035).
文摘Natural hybridization is known to play a vital role in speciation;however,the mechanisms underlying the early stages of natural hybridization remain unclear.Where two plant species come into contact,two driving forces may balance the dynamic consequences of hybridization:fusion by hybridization-mediated gene flow,and separation by reproductive isolation(RI)(Ma et al.,2010a,b;Chang et al.,2022).
基金Supported by the Development and Application Project of Ship CAE Software.
文摘Studies of wave-current interactions are vital for the safe design of structures.Regular waves in the presence of uniform,linear shear,and quadratic shear currents are explored by the High-Level Green-Naghdi model in this paper.The five-point central difference method is used for spatial discretization,and the fourth-order Adams predictor-corrector scheme is employed for marching in time.The domain-decomposition method is applied for the wave-current generation and absorption.The effects of currents on the wave profile and velocity field are examined under two conditions:the same velocity of currents at the still-water level and the constant flow volume of currents.Wave profiles and velocity fields demonstrate substantial differences in three types of currents owing to the diverse vertical distribution of current velocity and vorticity.Then,loads on small-scale vertical cylinders subjected to regular waves and three types of background currents with the same flow volume are investigated.The maximum load intensity and load fluctuation amplitude in uniform,linear shear,and quadratic shear currents increase sequentially.The stretched superposition method overestimates the maximum load intensity and load fluctuation amplitude in opposing currents and underestimates these values in following currents.The stretched superposition method obtains a poor approximation for strong nonlinear waves,particularly in the case of the opposing quadratic shear current.
基金Funded by the National Natural Science Foundation of China(Nos.52278518 and 51938011)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.24KJB560021)。
文摘Based on the split hopkinson pressure bar(SHPB)tests results,the cubic specimens have been numerically modeled in this paper to investigate the impact of key factors,such as the rise time,duration,and incident pulse shape,on achieving stress uniformity.After analysis,the paper provides actionable methods aimed at optimizing the conditions for stress uniformity within the cubic specimen.Finally,the lateral inertia effect of cubic specimen has been scrutinized to address the existing gap in this academic area.
基金support from the National Natural Science Foundation of China(Grant Nos.42377144,52225904 and 52039007)supported by the New Cornerstone Science Foundation through the XPLORER PRIZE.
文摘Freeze-thaw(F-T)cycle is receiving increasing attention as a primary threat to the long-term stability of rock engineering in high-elevation regions.In this study,artificial F-T cycle tests are first conducted on pre-flawed sandstone specimens with real-time frost heave pressure(FHP)monitoring,followed by subsequent cyclic loading tests with different maximum stresses.Given the water-ice-sandstone interaction,the evolution process of FHP in flaws can be divided into six phases,i.e.initial,silence,eruption,reduction,second-arising,and dissipation phases.Its magnitude exhibits an exponential decrease with increasing F-T cycle number.The influences of F-T cycles and the maximum stress on the fatigue mechanical characteristics of flawed sandstone are revealed.Subjected to higher F-T cycles and maximum stress,larger irreversible strain and less dissipated energy are accumulated inside flawed sandstone specimens,leading to faster damage and lower fatigue life.The three-stage evolution characters of irreversible strain and dissipated energy are both weakened by repeated F-T treatment,i.e.the prolonged initial and accelerated stages and shortened stable stage.In addition,the repeated F-T cycles diminish the impact of prefabricated flaws on cracking behavior of flawed sandstone specimens,and the fatigue failure pattern changes from shear-dominated failure with a transfixion shear band to tensile-dominated failure with massive tensile cracks as the F-T cycle number increases.Employing the scanning electron microscopy(SEM),the underlying damage mechanisms of flawed rocks under the coupling effect of F-T treatment and cyclic loading are discussed.Finally,an F-T-fatigue damage model is proposed based on FHP evolution and irreversible strain,which possesses distinct physical significance and reasonably quantifies the F-T deterioration and fatigue damage accumulation of flawed rocks.
基金sponsored by National Natural Science Foundation of China(Grant Nos.U22B6003 and 52304070)Key Laboratory of Geomechanics and Geotechnical Engineering Safety,Chinese Academy of Sciences(Grant No.SKLGME-JBGS2404).
文摘Large-scale geological energy storage plays a crucial role in balancing the intermittency of renewable energy.As an energy storage medium,soaked sandstone has a wide range of applications in geological energy storage.Understanding the damage characteristics in soaked sandstones is essential for ensuring the stability and longevity of these energy storage systems.This study involved multi-stage cyclic loading tests conducted on soaked sandstone to explore the damage evolution throughout the loading process.The findingsreveal several important insights:(1)The plastic hysteresis loops observed during multi-stage cyclic loading evolved from dense to sparse.An increase in stress level led to greater damage in the rock,as evidenced by an increase in accumulated peak/plastic strains.(2)Energy density and stress level are related by quadratic polynomial relationships.The elastic and dissipated energy densities are related by a linear law.The average energy storage coefficientdecreased by up to 24.1%with increasing stress amplitude,reflectingchanges in energy dynamics within the samples.(3)AE counts,amplitude,and frequency provided critical insights into rock damage and fracture patterns.The greater the loading rate and stress amplitude,the lower the proportion of high-amplitude,high-peak frequency,and shear-type fractures.Increasing stress amplitude caused a maximum 16.63%reduction in the AE bvalue,indicating shifts in fracture behavior under varying stress conditions.(4)The increase in loading rate and stress amplitude promotes the transformation of micropores and mesopores to macropores/microcracks.(5)Damage variables,definedin terms of cumulative dissipation energy,aligned closely with the fatigue damage model under multi-stage cyclic loading.Accelerated damage primarily occurred during the finalstages of fatigue loading,highlighting critical periods in the degradation of soaked sandstones.This study can offer guidance for designing operational parameters for energy storage geological bodies dominated by soaked sandstones.
