Nanotechnology has provided thousands of novel nano-antimicrobials possessing features uncommon in clinically available antimicrobials.Here,nanocarriers loaded with conventional antimicrobials and responding to enviro...Nanotechnology has provided thousands of novel nano-antimicrobials possessing features uncommon in clinically available antimicrobials.Here,nanocarriers loaded with conventional antimicrobials and responding to environmental changes upon entry into oral biofilms are reviewed.Supra-gingival biofilms are characterized by acidic pH,the presence of bacterial enzymes,and the development of hypoxia in deeper layers.Sub-gingival biofilms are slightly alkaline,with hypoxia occurring over their entire depth.Upon entering biofilms,negatively charged,pH-and/or hypoxia-responsive nanocarriers become positively charged.This charge reversal leads to electrostatic double-layer attraction between positively charged nanocarriers towards negatively charged,waterfilled channel walls in biofilms,enhancing their accumulation in a biofilm.Degradation of bacterial enzyme-responsive nanocarriers causes in-biofilm release of antimicrobial cargo,yielding higher local antimicrobial concentrations than can be achieved through their direct,oral administration without harming soft tissues.Enhanced antibiofilm activity after in-biofilm antimicrobial release from biofilm-responsive micelles and liposomes has been demonstrated in vitro towards single-species Streptococcus mutans and Staphylococcus aureus biofilms or in vivo using specific-pathogen-free rodents inoculated with selected pathogens.This preferential antibacterial activity regulated the microbial composition of ex vivo human oral biofilm towards a more healthy microbiome composition.Although clinical confirmation is limited,the potential benefits of stimuli-responsive,antimicrobial-loaded nanocarriers for oral biofilm control and microbiome restoration are worth further investigation towards clinical translation.展开更多
More than 200 years after Parkinson's disease was first described by the English surgeon whose name would eventually be given to the condition,available treatments remain purely symptomatic,leaving a critical unme...More than 200 years after Parkinson's disease was first described by the English surgeon whose name would eventually be given to the condition,available treatments remain purely symptomatic,leaving a critical unmet clinical need for a diseasemodifying therapy.展开更多
A coal-loaded charge induction monitoring system is developed to effectively forecast the dynamic disasters caused by coal failure.Specifically,a digital finite impulse response(FIR)filter is designed to denoise and f...A coal-loaded charge induction monitoring system is developed to effectively forecast the dynamic disasters caused by coal failure.Specifically,a digital finite impulse response(FIR)filter is designed to denoise and filter the signal,and the time-frequency domain evolution of induced charge signals is analyzed during coal failure experiments.The quantitative relationships between the induced electric charge and stress-strain energy,and ultimately,between induced electric charge and coal deformation/failure,are revealed.Ultimately,the electric charge sensor exhibits high signal collection frequency and high sensitivity,and the FIR low-pass filter constructed in MATLAB effectively denoises and filters induced charge signals.The main frequency range of the white noise is 50-500 Hz,and the main frequency of the charge signal induced by coal deformation and failure is concentrated in the range of 0-50 Hz.The optimal distances for monitoring cubic and cylindrical raw coal samples using this sensor are 9 mm and 11 mm,respectively.Notably,strain energy is released faster when it can dissipate more readily,and induced charge pulses become denser when more intense signals produce large fluctuations.A method is proposed to identify coal deformation and failure based on changes in the induced electric charge.This study provides a new means of monitoring the early warning signs of dynamic coal mine disasters.Based on our experimental results and conclusions,a new method is proposed to identify coal deformation and failure based on changes in the induced electric charge.The precursor to the moment of coal failure can be identified by monitoring the amplitude of the induced charge,the dynamic trend of fluctuation,and the cumulative number of induced electric charge pulses during the process of coal deformation.展开更多
Tooth cracks may occur in spiral bevel gear transmission system of the aerospace equipment.In this study,an accurate and efficient loaded tooth contact analysis(LTCA)model is developed to predict the contact behavior ...Tooth cracks may occur in spiral bevel gear transmission system of the aerospace equipment.In this study,an accurate and efficient loaded tooth contact analysis(LTCA)model is developed to predict the contact behavior and time-varying meshing stiffness(TVMS)of spiral bevel gear pair with cracked tooth.The tooth is sliced,and the contact points on slices are computed using roll angle surfaces.Considering the geometric complexity of crack surface,a set of procedures is formulated to generate spatial crack and determine crack parameters for contact points.According to the positional relationship between contact point and crack path,each sliced tooth is modeled as a non-uniform cantilever beam with varying reduced effective load-bearing tooth thickness.Then the compliance model of the cracked tooth is established to perform contact analysis,along with TVMS calculations utilizing three different models.By employing spiral bevel gear pairs with distinct types of cracks as examples,the accuracy and efficiency of the developed approach are validated via comparative analyses with finite element analysis(FEA)outcomes.Furthermore,the investigation on effects of cracks shows that tooth cracks can induce alterations in meshing performance of both entire gear pair and individual tooth pairs,including not only cracked tooth pair but also adjacent non-cracked tooth pairs.Hence,the proposed model can serve as a useful tool for analyzing the variations in contact behavior and meshing stiffness of spiral bevel gears due to different cracks.展开更多
Skin sensitization is a common adverse effect of a wide range of small reactive chemicals,leading to allergic contact dermatitis(ACD),the most frequent manifestation of immunotoxicity in humans.The prevalence of ACD i...Skin sensitization is a common adverse effect of a wide range of small reactive chemicals,leading to allergic contact dermatitis(ACD),the most frequent manifestation of immunotoxicity in humans.The prevalence of ACD is increasing,affecting up to 20%of the Western European population.This trend was particularly pronounced in high-risk occupational sectors,including healthcare,food services,metal and construction workers,and hairdressers[1].The skin sensitization adverse outcome pathway(AOP)comprises 11 elements,with four designated key events(KEs):formation of proteinhapten complexes(KE-1),inflammatory keratinocyte response(KE-2),dendritic cell(DC)activation(KE-3),and T-cell proliferation(KE-4)[2].As there is no cure for ACD,preventive strategies are of great relevance.In addition to avoiding exposure,preventive measures,such as the use of latex gloves,barrier creams,emollients,and moisturizers,often have limited effectiveness[3].展开更多
Clay deposits typically exhibit significant degrees of heterogeneity and anisotropy in their strength and stiffness properties.Such non-monotonic responses can significantly impact the stability analysis and design of...Clay deposits typically exhibit significant degrees of heterogeneity and anisotropy in their strength and stiffness properties.Such non-monotonic responses can significantly impact the stability analysis and design of overlying shallow foundations.In this study,the undrained bearing capacity of shallow foundations resting on inhomogeneous and anisotropic clay layers subjected to oblique-eccentric combined loading is investigated through a comprehensive series of finite element limit analysis(FELA)based on the well-established lower-bound theorem and second-order cone programming(SOCP).The heterogeneity of normally consolidated(NC)clays is simulated by adopting a well-known general model of undrained shear strength increasing linearly with depth.In contrast,for overconsolidated(OC)clays,the variation of undrained shear strength with depth is considered to follow a bilinear trend.Furthermore,the inherent anisotropy is accounted for by adopting different values of undrained shear strength along different directions within the soil medium,employing an iterative-based algorithm.The results of numerical simulations are utilized to investigate the influences of natural soil heterogeneity and inherent anisotropy on the ultimate bearing capacity,failure envelope,and failure mechanism of shallow foundations subjected to the various combinations of vertical-horizontal(V-H)and vertical-moment(V-M)loads.展开更多
Borehole pressure relief helps prevent rock bursts.However,this may change the physical and mechan-ical properties of the surrounding rock,affect the variation of the plastic zone of the roadway,and lead to the failur...Borehole pressure relief helps prevent rock bursts.However,this may change the physical and mechan-ical properties of the surrounding rock,affect the variation of the plastic zone of the roadway,and lead to the failure of roadway support,thus threatening the safety of the roadway.In this paper,the variable angle shear test of drilled specimens under the action of static and dynamic loads is used to study the evolution of mechanical parameters of the specimens and their influence on the plastic zone of the sur-rounding rock.The shear strength decreases linearly with the increase of drilling diameter.With the increase of pre-static load level and dynamic load amplitude,the cohesion first increases and then decreases,and the internal friction angle decreases.Moreover,the shear failure surface changes from rough to smooth.The reasons include that the static load enhances the tooth cutting effect and the repeated friction of cracks caused by the dynamic load.Borehole pressure relief leads to an increase in the radius of the plastic zone of the surrounding rock following a quadratic function.The research results of this paper provide a theoretical basis for designing drilling unloading parameters and supporting parameters for rock burst roadways.展开更多
Metal(oxide)-zeolite bifunctional catalysts have been the subject of considerable attention from researchers in both academic and industry,due to their superior activity and stability in various heterogeneous catalyti...Metal(oxide)-zeolite bifunctional catalysts have been the subject of considerable attention from researchers in both academic and industry,due to their superior activity and stability in various heterogeneous catalytic processes[1–3].Based on the different metal loading sites,these bifunctional catalysts can be categorized as follows:(a)metal species loaded on the outer surface of zeolite crystals,(b)metal species encapsulated within the channels or cavities of zeolites,and(c)metal species incorporated into the zeolite framework(Fig.1).Metal species in type(b)and(c)samples are stabilized by the zeolite frameworks,resulting in excellent thermal and hydrothermal stability during catalytic reactions,especially under harsh conditions,as well as unique shape-selectivity.However,the complex synthesis procedures make large-scale preparation of these catalysts impractical.In contrast,a type(a)sample can be achieved via the simple impregnation;nevertheless,migration of metal species and their aggregation into larger particles often occur during the calcination and reduction processes.展开更多
This article experimentally studies the effects of air injection near the blade trailing edge on flow separation and losses in a highly loaded linear compressor cascade. Aerodynamic parameters of eight cascades with d...This article experimentally studies the effects of air injection near the blade trailing edge on flow separation and losses in a highly loaded linear compressor cascade. Aerodynamic parameters of eight cascades with different air injection slot configura- tions are measured by using a five-hole probe at the cascade outlets. Ink-trace flow visualization is performed to obtain the flow details around the air injection slots. The static pressure distribution is clarified with pressure taps on the endwalls. The...展开更多
There is still no effective therapy for muscle atrophy.It found that miR-194 was significantlydownregulated in muscle atrophy model.miR-194 could promote muscle differentiation,and also inhibit ubiquitin ligases.miR-1...There is still no effective therapy for muscle atrophy.It found that miR-194 was significantlydownregulated in muscle atrophy model.miR-194 could promote muscle differentiation,and also inhibit ubiquitin ligases.miR-194 loaded in gelatin nanosphere were injected into the muscle atrophy model to realize controlled release.展开更多
Articular cartilage maintains joint homeostasis by adapting to mechanical loading,but both insufficient and excessive loading can impair cartilage integrity.Whether mechanical activity should be restricted in early os...Articular cartilage maintains joint homeostasis by adapting to mechanical loading,but both insufficient and excessive loading can impair cartilage integrity.Whether mechanical activity should be restricted in early osteoarthritis(OA),particularly among exercise enthusiasts,remains controversial.Here,we established in vitro and in vivo models of prolonged moderate mechanical loading(7.5%strain,1 Hz)and analyzed human cartilage from weight-bearing and non-weight-bearing regions using RNA sequencing.Prolonged exposure(≥12 h)significantly increased chondrocyte apoptosis(2.3-fold),reduced expression of the chondrogenic transcription factor SOX9 and the matrix markers COL2A1,and elevated nerve growth factor(NGF)expression(1.8-fold),accompanied by enrichment of neural sensitization and inflammatory pathways.Immunofluorescence staining revealed NGF accumulation in mechanically stressed cartilage.Unlike high-intensity stress,which led to immediate apoptosis,moderate loading induced a delayed pro-apoptotic response after 12 h.These findings indicate that prolonged moderate mechanical loading may promote chondrocyte apoptosis through an NGFmediated inflammatory microenvironment and provide mechanistic evidence suggesting that patients with early OA may benefit from limiting high-impact or prolonged moderate-intensity exercise sessions to prevent cartilage damage and guide rehabilitation.展开更多
The stress minimization multi-material topology optimization(MMTO)approach has recently attracted significant attention because of its applications in aerospace and mechanical engineering.Nonetheless,the stress minimi...The stress minimization multi-material topology optimization(MMTO)approach has recently attracted significant attention because of its applications in aerospace and mechanical engineering.Nonetheless,the stress minimization MMTO approach may result in stress surpassing the material's tolerance limit,potentially culminating in failure.This research proposes a novel way for imposing stress constraints on each material to regulate their respective stress levels.The fundamental concept is that each material possesses its own interpolation function for the stress model.The maximum von Mises stress for each material can be established with the definition of an upper limit,ensuring that the materials will perform safely and effectively.This aids topological structures in resisting failure and augmenting strength.A multi-physics system including thermoelastic and self-weight loads is concurrently examined alongside stress limitations.The global stress constraint utilizes the p-norm function,and the adjoint method is used to derive sensitivity.This work employs a three-field strategy utilizing density filtering and Heaviside projection functions to mitigate the artificial stress in low density.The technique is assessed through two-dimensional(2D)and three-dimensional(3D)examples,illustrating the influence of stress limits on the compliance minimization under heat and self-weight loads.The optimized results indicate a substantial decrease in the stress levels accompanied by a minor gain in compliance,while maintaining the stress within the specified range for all materials.展开更多
Load frequency control(LFC)is a critical function to balance the power consumption and generation.Thegrid frequency is a crucial indicator for maintaining balance.However,the widely used information and communication ...Load frequency control(LFC)is a critical function to balance the power consumption and generation.Thegrid frequency is a crucial indicator for maintaining balance.However,the widely used information and communication infrastructure for LFC increases the risk of being attacked by malicious actors.The dynamic load altering attack(DLAA)is a typical attack that can destabilize the power system,causing the grid frequency to deviate fromits nominal value.Therefore,in this paper,we mathematically analyze the impact of DLAA on the stability of the grid frequency and propose the network parameter regulation(NPR)to mitigate the impact.To begin with,the dynamic LFC model is constructed by highlighting the importance of the network parameter.Then,we model the DLAA and analyze its impact on LFC using the theory of second-order dynamic systems.Finally,we model the NPR and prove its effect in mitigating the DLAA.Besides,we construct a least-effort NPR considering its infrastructure cost and aim to reduce the operation cost.Finally,we carry out extensive simulations to demonstrate the impact of the DLAA and evaluate the mitigation performance of NPR.The proposed cost-benefit NPR approach can not only mitigate the impact of DLAA with 100%and also save 41.18$/MWh in terms of the operation cost.展开更多
This paper studies the structural response of high-speed train wipers under the combined action of complex flow fields and scraping actions.The stress concentration areas are determined through simulation analysis,and...This paper studies the structural response of high-speed train wipers under the combined action of complex flow fields and scraping actions.The stress concentration areas are determined through simulation analysis,and the stress and aerodynamic load measurement points are reasonably arranged accordingly.The actual measurement is carried out in combination with the operating conditions of the existing lines.The stress variations and spectral characteristics of the train under different speed levels(80,160,180,200 km/h),tunnel entry and exit,and scraper action conditions were compared and analyzed.The stress amplification factors under tunnel intersection and scraper action were obtained,providing boundary conditions for the design of wipers for highspeed s.The research results show that the maximum stress of the wiper structure obtained through simulation calculation is concentrated at the connection of the wiper arm.Structural stress increases with the rise of speed grade.The stress increases by 1.11 times when the tunnel meets.When the scraper operates,the stress on the scraper arm increases by 4.1–7.6 times.Due to the broadband excitation effect of the aerodynamic load,the spectral energy of the structure is relatively high at the natural frequency,which excites the natural mode of the wiper.展开更多
Conventionally,foundations have been classified as shallow or deep in routine civil engineering practice.However,due to recent developments,two other approaches,semi-deep and ground modification foundations,are now av...Conventionally,foundations have been classified as shallow or deep in routine civil engineering practice.However,due to recent developments,two other approaches,semi-deep and ground modification foundations,are now available,complicating foundation categorization.Accordingly,a new concept for foundation categorization is introduced in this paper based on insights into the theory of structure analysis.Based on the form aspect,foundation systems can be categorized as one-dimensional(linear),two-dimensional(planar),and threedimensional(volumetric).Based on the load transfer aspect,foundations can also be categorized as vector-acting(piles),section or surface-acting(rafts and shells),and block-acting(piled rafts).As a step toward implementing this new categorization scheme,a database of 22 cases has been compiled,symbolizing novel introduced foundation systems.This compilation involves structures such as offshore jackets,high-rise buildings,towers and storages,and diverse geomaterials.Among them,a few have been selected for detailed evaluation,emphasizing influential factors in foundation selection,comprising superstructure,subsoil condition,foundation system,circumferential conditions,and supplementary considerations,that is,constructional and sustainability-based issues.Lessons learned from experience and these knowledge-based cases have described for foundation selection and implementation.Geotechnical and practical aspects with critical components have been realized as major performance assessment and comparison factors.Foundation systems have been compared and ranked using the improved analytic hierarchy process approach.Finally,four categories of buildings,from low-rise to towers and four prevailing levels of soil strength,from soft to very hard,have been considered to propose a perspective for building substructure implementation,adapted via relevant cases.Overall,the introduced categorization is recognized as an efficient algorithm for the experimentation of appropriate foundations for specific structures and subsoil conditions.展开更多
LEO satellite communication systems have the characteristics of high-speed and periodic movement.The handover of user link occurs frequently,which has a serious impact on user terminal application and system capacity....LEO satellite communication systems have the characteristics of high-speed and periodic movement.The handover of user link occurs frequently,which has a serious impact on user terminal application and system capacity.To address this issue,we propose a handover strategy of LEO satellite user terminal based on multi-attribute and multi-point(MAMP)cooperation.Firstly,the satellite-user-time matrix is established by using the satellite constellation coverage and handover model.Then,combined with the visual time and signal quality,the user access matrix and satellite load matrix are extracted to determine the weight equation of the handover strategy with the channel reservation.According to the system modeling simulation,the algorithm improves the handover success rate by 2.5%,the lasted call access success rate by 3.2%,the load balancing degree by 20%,and the robustness by two orders of magnitude.展开更多
The contact deformation and buckling of elastic rods against rigid surfaces represent a prevalent phenomenon in applications such as oil drilling,arterial stents,and energy harvesting.This has attracted widespread att...The contact deformation and buckling of elastic rods against rigid surfaces represent a prevalent phenomenon in applications such as oil drilling,arterial stents,and energy harvesting.This has attracted widespread attention from researchers.In this paper,the deformation and buckling behaviors of a circular arch subject to compression by a rigid plate are investigated with a planar elastic rod model that incorporates tension,shearing,and bending.In comparison with the existing models that solely consider the bending energy,the deflection curve,the internal force distribution,and the critical load of the present model show good agreement with the finite element results.Through the dimensional analysis and order-of-magnitude estimation,we examine the factors influencing the critical load.The study reveals that the semi-central angle of the arch has the most significant effect.The dimensionless geometric parameter describing arch slenderness becomes prominent when the semi-central angle is less than 30°,while Poisson's ratio and the cross-sectional shear correction factor exhibit negligible influence.Furthermore,the variation in the proportions of strain energy components during critical buckling is presented with respect to the semi-central angle and the geometric parameter,thereby delineating the applicable ranges of both the original model(OM)and the modified model(MM).展开更多
The variation laws of runoff and sediment load under different climate,vegetation,and human activity scenarios are significantly different.Exploring the impacts of climate change and human activities on runoff and sed...The variation laws of runoff and sediment load under different climate,vegetation,and human activity scenarios are significantly different.Exploring the impacts of climate change and human activities on runoff and sediment load dynamics can provide a profound understanding of the mechanism of runoff and sediment load variability in basins,which is crucial for the sustainable development of regional ecosystems.This study investigates the Tao River Basin(TRB)on the Tibetan Plateau,as well as the Zuli River Basin(ZRB)and Jing River Basin(JRB)on the Loess Plateau,to differentiate the impacts of climate change and human activities on runoff and sediment load dynamics.The runoff and sediment load of the three watersheds have shown a decreasing trend over the past 40 years,and combined with the DMC(Dual mass curve)method,it was found that the slope of the runoff sediment gradually tends to flatten out.After the time period was divided,the CA(Cumulative anomaly)method was used for verification,which revealed good correspondence between the two before 2000 and then gradual deviations.The power function best represents the relationship between runoff and sediment load.During the initial period,climate had a significant impact on runoff variation in the TRB and JRB,with contribution rates of-54.93%and-63.02%,respectively.In the later period,human activities became the dominant influence,contributing more than-60%of the runoff variation.In the ZRB,human activities consistently dominated runoff variation,with contribution rates of-72.72%and-55.66%during both periods.In the early stages of research,the impact of climate change on sediment load was more severe in the TRB and JRB,and human activities played a significant role in the later stages.However,in the ZRB,human activities have always been the main contributor.Based on the actual local situation,runoff and sediment load in the TRB are influenced primarily by engineering measures,and vegetation and check dams exert greater impacts on the ZRB and JRB.This study explores the attribution of water and sediment load changes in different ecological geographic regions from a comparative perspective,providing a valuable theoretical basis and reference for understanding global runoff and sediment transport changes in similar areas.展开更多
The synergistic effects of corrosion and impact loading on the microstructure evolution and dynamic mechanical properties of ultrahigh-strength AerMet 100 steel are investigated.Through integrated experiments and mode...The synergistic effects of corrosion and impact loading on the microstructure evolution and dynamic mechanical properties of ultrahigh-strength AerMet 100 steel are investigated.Through integrated experiments and modeling,the result reveals that the corrosion leads to grain refinement and a reduction in the proportion of low-angle grain boundaries.Notably,corrosion promotes austenite enrichment(increasing from 1.8%to 13.9%)through selective dissolution of the martensitic matrix,while repetitive impacts reverse this trend(reducing to 0.1%)through stress-induced martensitic transformation.Fracture analysis demonstrates corrosion-induced ductile-to-brittle transition,with quasi-cleavage features dominating after prolonged corrosion.A physics-based dynamic yield strength model with<3%prediction error relative to impact tests is developed.These findings establish microstructure-property relationships of AerMet 100 steel under multi-field coupling,providing critical guidance for designing corrosion-resistant ultrahigh-strength steels in marine-impact environments.展开更多
基金supported by the National Science Fund for Excellent Young Scholars (32322044)the CQMU Program for Youth Innovation in Future Medicine (W0077)+1 种基金the Program for Scientific and Technological Innovation Leader of Chongqing (CQYC20220303655)the Young Scientists Fund of the National Natural Science Foundation of China (82301144)。
文摘Nanotechnology has provided thousands of novel nano-antimicrobials possessing features uncommon in clinically available antimicrobials.Here,nanocarriers loaded with conventional antimicrobials and responding to environmental changes upon entry into oral biofilms are reviewed.Supra-gingival biofilms are characterized by acidic pH,the presence of bacterial enzymes,and the development of hypoxia in deeper layers.Sub-gingival biofilms are slightly alkaline,with hypoxia occurring over their entire depth.Upon entering biofilms,negatively charged,pH-and/or hypoxia-responsive nanocarriers become positively charged.This charge reversal leads to electrostatic double-layer attraction between positively charged nanocarriers towards negatively charged,waterfilled channel walls in biofilms,enhancing their accumulation in a biofilm.Degradation of bacterial enzyme-responsive nanocarriers causes in-biofilm release of antimicrobial cargo,yielding higher local antimicrobial concentrations than can be achieved through their direct,oral administration without harming soft tissues.Enhanced antibiofilm activity after in-biofilm antimicrobial release from biofilm-responsive micelles and liposomes has been demonstrated in vitro towards single-species Streptococcus mutans and Staphylococcus aureus biofilms or in vivo using specific-pathogen-free rodents inoculated with selected pathogens.This preferential antibacterial activity regulated the microbial composition of ex vivo human oral biofilm towards a more healthy microbiome composition.Although clinical confirmation is limited,the potential benefits of stimuli-responsive,antimicrobial-loaded nanocarriers for oral biofilm control and microbiome restoration are worth further investigation towards clinical translation.
基金funded by The Michael J.Fox Foundation for Parkinson’s Research(grant numbers:17244 and 023410)Science Foundation Ireland(grant number:19/FFP/6554)(to ED)。
文摘More than 200 years after Parkinson's disease was first described by the English surgeon whose name would eventually be given to the condition,available treatments remain purely symptomatic,leaving a critical unmet clinical need for a diseasemodifying therapy.
基金supported by the National Key Research and Development Project of the National Natural Science Foundation(Grant No.2022YFC3004605)the National Natural Science Foundation of China Youth Science Fund(Grant No.52104087).
文摘A coal-loaded charge induction monitoring system is developed to effectively forecast the dynamic disasters caused by coal failure.Specifically,a digital finite impulse response(FIR)filter is designed to denoise and filter the signal,and the time-frequency domain evolution of induced charge signals is analyzed during coal failure experiments.The quantitative relationships between the induced electric charge and stress-strain energy,and ultimately,between induced electric charge and coal deformation/failure,are revealed.Ultimately,the electric charge sensor exhibits high signal collection frequency and high sensitivity,and the FIR low-pass filter constructed in MATLAB effectively denoises and filters induced charge signals.The main frequency range of the white noise is 50-500 Hz,and the main frequency of the charge signal induced by coal deformation and failure is concentrated in the range of 0-50 Hz.The optimal distances for monitoring cubic and cylindrical raw coal samples using this sensor are 9 mm and 11 mm,respectively.Notably,strain energy is released faster when it can dissipate more readily,and induced charge pulses become denser when more intense signals produce large fluctuations.A method is proposed to identify coal deformation and failure based on changes in the induced electric charge.This study provides a new means of monitoring the early warning signs of dynamic coal mine disasters.Based on our experimental results and conclusions,a new method is proposed to identify coal deformation and failure based on changes in the induced electric charge.The precursor to the moment of coal failure can be identified by monitoring the amplitude of the induced charge,the dynamic trend of fluctuation,and the cumulative number of induced electric charge pulses during the process of coal deformation.
基金co-supported by the National Natural Science Foundation of China (No. 52175104)the Postdoctoral Fellowship Program of CPSF (No. GZC20233008)
文摘Tooth cracks may occur in spiral bevel gear transmission system of the aerospace equipment.In this study,an accurate and efficient loaded tooth contact analysis(LTCA)model is developed to predict the contact behavior and time-varying meshing stiffness(TVMS)of spiral bevel gear pair with cracked tooth.The tooth is sliced,and the contact points on slices are computed using roll angle surfaces.Considering the geometric complexity of crack surface,a set of procedures is formulated to generate spatial crack and determine crack parameters for contact points.According to the positional relationship between contact point and crack path,each sliced tooth is modeled as a non-uniform cantilever beam with varying reduced effective load-bearing tooth thickness.Then the compliance model of the cracked tooth is established to perform contact analysis,along with TVMS calculations utilizing three different models.By employing spiral bevel gear pairs with distinct types of cracks as examples,the accuracy and efficiency of the developed approach are validated via comparative analyses with finite element analysis(FEA)outcomes.Furthermore,the investigation on effects of cracks shows that tooth cracks can induce alterations in meshing performance of both entire gear pair and individual tooth pairs,including not only cracked tooth pair but also adjacent non-cracked tooth pairs.Hence,the proposed model can serve as a useful tool for analyzing the variations in contact behavior and meshing stiffness of spiral bevel gears due to different cracks.
基金support was provided by the European Regional Development Fund(ERDF),through the Centro 2020 Regional Operational Programme,Portugal(Project No.:CENTRO-01-0145-FEDER-000012(HealthyAging2020))through the COMPETE 2020-Operational Programme for Competitiveness and Internationalisation and Portuguese National Funds via Fundaçao para a Ciencia e a Tecnologia,Portugal(Project Nos.:POCI-01-0145-FEDER-029369 UIDB/04539/2020,iBiMED UIDB/04501/2020,DOI identifier https://doi.org/10.54499/UIDB/04501/2020 and project reference UIDP/04501/2020,DOI identifier https://doi.org/10.54499/UIDP/04501/2020,and LA/P/0058/2020)supported by Fundaçao para a Ciencia e a Tecnologia through the individual PhD fellowships,Portugal(Grant Nos.:PD/BDE/142926/2018 and SFRH/BD/110717/2015)。
文摘Skin sensitization is a common adverse effect of a wide range of small reactive chemicals,leading to allergic contact dermatitis(ACD),the most frequent manifestation of immunotoxicity in humans.The prevalence of ACD is increasing,affecting up to 20%of the Western European population.This trend was particularly pronounced in high-risk occupational sectors,including healthcare,food services,metal and construction workers,and hairdressers[1].The skin sensitization adverse outcome pathway(AOP)comprises 11 elements,with four designated key events(KEs):formation of proteinhapten complexes(KE-1),inflammatory keratinocyte response(KE-2),dendritic cell(DC)activation(KE-3),and T-cell proliferation(KE-4)[2].As there is no cure for ACD,preventive strategies are of great relevance.In addition to avoiding exposure,preventive measures,such as the use of latex gloves,barrier creams,emollients,and moisturizers,often have limited effectiveness[3].
文摘Clay deposits typically exhibit significant degrees of heterogeneity and anisotropy in their strength and stiffness properties.Such non-monotonic responses can significantly impact the stability analysis and design of overlying shallow foundations.In this study,the undrained bearing capacity of shallow foundations resting on inhomogeneous and anisotropic clay layers subjected to oblique-eccentric combined loading is investigated through a comprehensive series of finite element limit analysis(FELA)based on the well-established lower-bound theorem and second-order cone programming(SOCP).The heterogeneity of normally consolidated(NC)clays is simulated by adopting a well-known general model of undrained shear strength increasing linearly with depth.In contrast,for overconsolidated(OC)clays,the variation of undrained shear strength with depth is considered to follow a bilinear trend.Furthermore,the inherent anisotropy is accounted for by adopting different values of undrained shear strength along different directions within the soil medium,employing an iterative-based algorithm.The results of numerical simulations are utilized to investigate the influences of natural soil heterogeneity and inherent anisotropy on the ultimate bearing capacity,failure envelope,and failure mechanism of shallow foundations subjected to the various combinations of vertical-horizontal(V-H)and vertical-moment(V-M)loads.
基金supported by the National Natural Science Foundation of China(Nos.52374100,52525401,and 52304150)Outstanding Young Talent Project of Shanxi Province(No.SJYC2024301)Research Project Supported by Shanxi Scholarship Council of China(No.2023-041).
文摘Borehole pressure relief helps prevent rock bursts.However,this may change the physical and mechan-ical properties of the surrounding rock,affect the variation of the plastic zone of the roadway,and lead to the failure of roadway support,thus threatening the safety of the roadway.In this paper,the variable angle shear test of drilled specimens under the action of static and dynamic loads is used to study the evolution of mechanical parameters of the specimens and their influence on the plastic zone of the sur-rounding rock.The shear strength decreases linearly with the increase of drilling diameter.With the increase of pre-static load level and dynamic load amplitude,the cohesion first increases and then decreases,and the internal friction angle decreases.Moreover,the shear failure surface changes from rough to smooth.The reasons include that the static load enhances the tooth cutting effect and the repeated friction of cracks caused by the dynamic load.Borehole pressure relief leads to an increase in the radius of the plastic zone of the surrounding rock following a quadratic function.The research results of this paper provide a theoretical basis for designing drilling unloading parameters and supporting parameters for rock burst roadways.
基金financially supported by the National Key R&D Program of China(2024YFE0101100)the National Natural Science Foundation of China(22475112,22305132,22305155)+1 种基金the China Postdoctoral Science Foundation(2023M732323)the Postdoctoral Fellowship Program of CPSF(GZC20231679).
文摘Metal(oxide)-zeolite bifunctional catalysts have been the subject of considerable attention from researchers in both academic and industry,due to their superior activity and stability in various heterogeneous catalytic processes[1–3].Based on the different metal loading sites,these bifunctional catalysts can be categorized as follows:(a)metal species loaded on the outer surface of zeolite crystals,(b)metal species encapsulated within the channels or cavities of zeolites,and(c)metal species incorporated into the zeolite framework(Fig.1).Metal species in type(b)and(c)samples are stabilized by the zeolite frameworks,resulting in excellent thermal and hydrothermal stability during catalytic reactions,especially under harsh conditions,as well as unique shape-selectivity.However,the complex synthesis procedures make large-scale preparation of these catalysts impractical.In contrast,a type(a)sample can be achieved via the simple impregnation;nevertheless,migration of metal species and their aggregation into larger particles often occur during the calcination and reduction processes.
基金National Natural Science Foundation of China (50876023)Chinese Specialized Research Fund for the Doctoral Pro-gram of Higher Education (20060213007)National Basic Research Program of China (2007CB210100)
文摘This article experimentally studies the effects of air injection near the blade trailing edge on flow separation and losses in a highly loaded linear compressor cascade. Aerodynamic parameters of eight cascades with different air injection slot configura- tions are measured by using a five-hole probe at the cascade outlets. Ink-trace flow visualization is performed to obtain the flow details around the air injection slots. The static pressure distribution is clarified with pressure taps on the endwalls. The...
文摘There is still no effective therapy for muscle atrophy.It found that miR-194 was significantlydownregulated in muscle atrophy model.miR-194 could promote muscle differentiation,and also inhibit ubiquitin ligases.miR-194 loaded in gelatin nanosphere were injected into the muscle atrophy model to realize controlled release.
基金supported by the Zhejiang Medical and Health Innovation Talent Support Project(Grant No.2021RC128 to S.S.)Zhejiang Medicine and Health Science and Technology Project(2025KY1540 to J.J.L.)+3 种基金Zhejiang Province Health Science and Technology Project(2024KY409 and 2021KY1086 to J.Y.L.)Huzhou Science and Technology Planning Project(2020GY10 to W.L.,2022GZ65 to J.Y.L.)Huzhou Basic and Clinical Translation of Orthopedics Key Laboratory(Grant No.HZGKSYS01Y to S.S.)South Taihu Lake Outstanding Young Health Talents Cultivation Program(Grant No.rsk2023001 to S.S.).
文摘Articular cartilage maintains joint homeostasis by adapting to mechanical loading,but both insufficient and excessive loading can impair cartilage integrity.Whether mechanical activity should be restricted in early osteoarthritis(OA),particularly among exercise enthusiasts,remains controversial.Here,we established in vitro and in vivo models of prolonged moderate mechanical loading(7.5%strain,1 Hz)and analyzed human cartilage from weight-bearing and non-weight-bearing regions using RNA sequencing.Prolonged exposure(≥12 h)significantly increased chondrocyte apoptosis(2.3-fold),reduced expression of the chondrogenic transcription factor SOX9 and the matrix markers COL2A1,and elevated nerve growth factor(NGF)expression(1.8-fold),accompanied by enrichment of neural sensitization and inflammatory pathways.Immunofluorescence staining revealed NGF accumulation in mechanically stressed cartilage.Unlike high-intensity stress,which led to immediate apoptosis,moderate loading induced a delayed pro-apoptotic response after 12 h.These findings indicate that prolonged moderate mechanical loading may promote chondrocyte apoptosis through an NGFmediated inflammatory microenvironment and provide mechanistic evidence suggesting that patients with early OA may benefit from limiting high-impact or prolonged moderate-intensity exercise sessions to prevent cartilage damage and guide rehabilitation.
基金Project supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.RS-2025-02303676)。
文摘The stress minimization multi-material topology optimization(MMTO)approach has recently attracted significant attention because of its applications in aerospace and mechanical engineering.Nonetheless,the stress minimization MMTO approach may result in stress surpassing the material's tolerance limit,potentially culminating in failure.This research proposes a novel way for imposing stress constraints on each material to regulate their respective stress levels.The fundamental concept is that each material possesses its own interpolation function for the stress model.The maximum von Mises stress for each material can be established with the definition of an upper limit,ensuring that the materials will perform safely and effectively.This aids topological structures in resisting failure and augmenting strength.A multi-physics system including thermoelastic and self-weight loads is concurrently examined alongside stress limitations.The global stress constraint utilizes the p-norm function,and the adjoint method is used to derive sensitivity.This work employs a three-field strategy utilizing density filtering and Heaviside projection functions to mitigate the artificial stress in low density.The technique is assessed through two-dimensional(2D)and three-dimensional(3D)examples,illustrating the influence of stress limits on the compliance minimization under heat and self-weight loads.The optimized results indicate a substantial decrease in the stress levels accompanied by a minor gain in compliance,while maintaining the stress within the specified range for all materials.
基金supported by the project Major Scientific and Technological Special Project of Guizhou Province([2024]014).
文摘Load frequency control(LFC)is a critical function to balance the power consumption and generation.Thegrid frequency is a crucial indicator for maintaining balance.However,the widely used information and communication infrastructure for LFC increases the risk of being attacked by malicious actors.The dynamic load altering attack(DLAA)is a typical attack that can destabilize the power system,causing the grid frequency to deviate fromits nominal value.Therefore,in this paper,we mathematically analyze the impact of DLAA on the stability of the grid frequency and propose the network parameter regulation(NPR)to mitigate the impact.To begin with,the dynamic LFC model is constructed by highlighting the importance of the network parameter.Then,we model the DLAA and analyze its impact on LFC using the theory of second-order dynamic systems.Finally,we model the NPR and prove its effect in mitigating the DLAA.Besides,we construct a least-effort NPR considering its infrastructure cost and aim to reduce the operation cost.Finally,we carry out extensive simulations to demonstrate the impact of the DLAA and evaluate the mitigation performance of NPR.The proposed cost-benefit NPR approach can not only mitigate the impact of DLAA with 100%and also save 41.18$/MWh in terms of the operation cost.
文摘This paper studies the structural response of high-speed train wipers under the combined action of complex flow fields and scraping actions.The stress concentration areas are determined through simulation analysis,and the stress and aerodynamic load measurement points are reasonably arranged accordingly.The actual measurement is carried out in combination with the operating conditions of the existing lines.The stress variations and spectral characteristics of the train under different speed levels(80,160,180,200 km/h),tunnel entry and exit,and scraper action conditions were compared and analyzed.The stress amplification factors under tunnel intersection and scraper action were obtained,providing boundary conditions for the design of wipers for highspeed s.The research results show that the maximum stress of the wiper structure obtained through simulation calculation is concentrated at the connection of the wiper arm.Structural stress increases with the rise of speed grade.The stress increases by 1.11 times when the tunnel meets.When the scraper operates,the stress on the scraper arm increases by 4.1–7.6 times.Due to the broadband excitation effect of the aerodynamic load,the spectral energy of the structure is relatively high at the natural frequency,which excites the natural mode of the wiper.
文摘Conventionally,foundations have been classified as shallow or deep in routine civil engineering practice.However,due to recent developments,two other approaches,semi-deep and ground modification foundations,are now available,complicating foundation categorization.Accordingly,a new concept for foundation categorization is introduced in this paper based on insights into the theory of structure analysis.Based on the form aspect,foundation systems can be categorized as one-dimensional(linear),two-dimensional(planar),and threedimensional(volumetric).Based on the load transfer aspect,foundations can also be categorized as vector-acting(piles),section or surface-acting(rafts and shells),and block-acting(piled rafts).As a step toward implementing this new categorization scheme,a database of 22 cases has been compiled,symbolizing novel introduced foundation systems.This compilation involves structures such as offshore jackets,high-rise buildings,towers and storages,and diverse geomaterials.Among them,a few have been selected for detailed evaluation,emphasizing influential factors in foundation selection,comprising superstructure,subsoil condition,foundation system,circumferential conditions,and supplementary considerations,that is,constructional and sustainability-based issues.Lessons learned from experience and these knowledge-based cases have described for foundation selection and implementation.Geotechnical and practical aspects with critical components have been realized as major performance assessment and comparison factors.Foundation systems have been compared and ranked using the improved analytic hierarchy process approach.Finally,four categories of buildings,from low-rise to towers and four prevailing levels of soil strength,from soft to very hard,have been considered to propose a perspective for building substructure implementation,adapted via relevant cases.Overall,the introduced categorization is recognized as an efficient algorithm for the experimentation of appropriate foundations for specific structures and subsoil conditions.
基金supported by the Innovation Funding of ICT,CAS under Grant(No.E261020)Jiangsu Key Research and Development Program of China(No.BE2021013-2)Zhejiang Key Research and Development Program(No.2021C01040).
文摘LEO satellite communication systems have the characteristics of high-speed and periodic movement.The handover of user link occurs frequently,which has a serious impact on user terminal application and system capacity.To address this issue,we propose a handover strategy of LEO satellite user terminal based on multi-attribute and multi-point(MAMP)cooperation.Firstly,the satellite-user-time matrix is established by using the satellite constellation coverage and handover model.Then,combined with the visual time and signal quality,the user access matrix and satellite load matrix are extracted to determine the weight equation of the handover strategy with the channel reservation.According to the system modeling simulation,the algorithm improves the handover success rate by 2.5%,the lasted call access success rate by 3.2%,the load balancing degree by 20%,and the robustness by two orders of magnitude.
基金Project supported by the National Natural Science Foundation of China(Nos.124B2043,U2241267,12172155,and 12302278)the Science and Technology Leading Talent Project of Gansu Province of China(No.23ZDKA0009)the Natural Science Foundation of Gansu Province of China(Nos.24JRRA473 and 24JRRA489)。
文摘The contact deformation and buckling of elastic rods against rigid surfaces represent a prevalent phenomenon in applications such as oil drilling,arterial stents,and energy harvesting.This has attracted widespread attention from researchers.In this paper,the deformation and buckling behaviors of a circular arch subject to compression by a rigid plate are investigated with a planar elastic rod model that incorporates tension,shearing,and bending.In comparison with the existing models that solely consider the bending energy,the deflection curve,the internal force distribution,and the critical load of the present model show good agreement with the finite element results.Through the dimensional analysis and order-of-magnitude estimation,we examine the factors influencing the critical load.The study reveals that the semi-central angle of the arch has the most significant effect.The dimensionless geometric parameter describing arch slenderness becomes prominent when the semi-central angle is less than 30°,while Poisson's ratio and the cross-sectional shear correction factor exhibit negligible influence.Furthermore,the variation in the proportions of strain energy components during critical buckling is presented with respect to the semi-central angle and the geometric parameter,thereby delineating the applicable ranges of both the original model(OM)and the modified model(MM).
基金funding from the Natural Science Foundation of Shanxi Province(202403021222245,20240302121217)。
文摘The variation laws of runoff and sediment load under different climate,vegetation,and human activity scenarios are significantly different.Exploring the impacts of climate change and human activities on runoff and sediment load dynamics can provide a profound understanding of the mechanism of runoff and sediment load variability in basins,which is crucial for the sustainable development of regional ecosystems.This study investigates the Tao River Basin(TRB)on the Tibetan Plateau,as well as the Zuli River Basin(ZRB)and Jing River Basin(JRB)on the Loess Plateau,to differentiate the impacts of climate change and human activities on runoff and sediment load dynamics.The runoff and sediment load of the three watersheds have shown a decreasing trend over the past 40 years,and combined with the DMC(Dual mass curve)method,it was found that the slope of the runoff sediment gradually tends to flatten out.After the time period was divided,the CA(Cumulative anomaly)method was used for verification,which revealed good correspondence between the two before 2000 and then gradual deviations.The power function best represents the relationship between runoff and sediment load.During the initial period,climate had a significant impact on runoff variation in the TRB and JRB,with contribution rates of-54.93%and-63.02%,respectively.In the later period,human activities became the dominant influence,contributing more than-60%of the runoff variation.In the ZRB,human activities consistently dominated runoff variation,with contribution rates of-72.72%and-55.66%during both periods.In the early stages of research,the impact of climate change on sediment load was more severe in the TRB and JRB,and human activities played a significant role in the later stages.However,in the ZRB,human activities have always been the main contributor.Based on the actual local situation,runoff and sediment load in the TRB are influenced primarily by engineering measures,and vegetation and check dams exert greater impacts on the ZRB and JRB.This study explores the attribution of water and sediment load changes in different ecological geographic regions from a comparative perspective,providing a valuable theoretical basis and reference for understanding global runoff and sediment transport changes in similar areas.
基金supported by the National Natural Science Foundation of China(12522203,12532003 and U2267252)National Technological Basic Research Program of China,the Development and Application Project of Ship CAE Softwarethe Science and Technology Innovation 2035 Major Project of Yongjiang under Grant(2025Z009).
文摘The synergistic effects of corrosion and impact loading on the microstructure evolution and dynamic mechanical properties of ultrahigh-strength AerMet 100 steel are investigated.Through integrated experiments and modeling,the result reveals that the corrosion leads to grain refinement and a reduction in the proportion of low-angle grain boundaries.Notably,corrosion promotes austenite enrichment(increasing from 1.8%to 13.9%)through selective dissolution of the martensitic matrix,while repetitive impacts reverse this trend(reducing to 0.1%)through stress-induced martensitic transformation.Fracture analysis demonstrates corrosion-induced ductile-to-brittle transition,with quasi-cleavage features dominating after prolonged corrosion.A physics-based dynamic yield strength model with<3%prediction error relative to impact tests is developed.These findings establish microstructure-property relationships of AerMet 100 steel under multi-field coupling,providing critical guidance for designing corrosion-resistant ultrahigh-strength steels in marine-impact environments.
