Organic fluorescent materials with multistimuli-responsive behaviors have attracted much attention because of their promising applications in diverse fields.Most chromophores exhibit bright emission in either dilute s...Organic fluorescent materials with multistimuli-responsive behaviors have attracted much attention because of their promising applications in diverse fields.Most chromophores exhibit bright emission in either dilute solutions or aggregation states,which inevitably suffer from the aggregation-caused quenching(ACQ)problem or encounter serious energy loss at low concentration.To overcome these limitations,dual-state emissive(DSE)materials with bright emission in both solution and solid states have been developed.However,most DSE materials only involve one or two stimulus-responsive behaviors.Herein,through combining characteristics of imidazopyridine N1 as well as manipulation of electronic structure and intermolecular interaction,DSE molecule TPA-IPBA with four multistimuli-responsive behaviors has been rationally and accurately prepared,which could be easily converted to ACQ(TPA-IPB)and AIE(aggregation-induced emission)(TPA-IPBCN)molecules.Under external stimuli,four types of multistimuli-responsive behaviors have been successfully achieved,including solvatochromism(redshift of 124 nm),mechanofluorochromism(redshift of 6 or 30 nm),reversible tricolor acidichromism(redshift of 148 nm)and solidphase polymorphism with solvent-dependent solid emission(from B-state to G-state,redshift of 52 nm).We explained four types of multistimuli-responsive behaviors in detail through nuclear magnetic resonance spectroscopies,theoretical calculations,single crystal analysis,and PXRD characterization.In addition,on the basis of our biological research on imidazo[1,2-α]-pyridines,we found that TPA-IPBA serves as a fluorescent probe to dynamically detect biological lipid droplets with high co-localization ability(PC=0.95).These results provide new insight into developing DSE materials via a delicate manipulation of molecular structure with acceptor-dependent tunable multistimuli-responsive properties and bioimaging applications.展开更多
Non-alcoholic fatty liver disease （NAFLD） is an epidemic metabolic condition driven by an underlying lipid homeostasis disorder. The lipid droplet （LD）, the main organelle involved in neutral lipid storage and hyd...Non-alcoholic fatty liver disease （NAFLD） is an epidemic metabolic condition driven by an underlying lipid homeostasis disorder. The lipid droplet （LD）, the main organelle involved in neutral lipid storage and hydrolysis, is a potential target for NAFLD therapeutic treat- ment. In this review, we summarize recent progress elucidating the connections between LD-associated proteins and NAFLD found by genome-wide association studies （GWAS）, genomic and proteomic studies. Finally, we discuss a possible mechanism by which the protein 17β-hydroxysteroid dehydrogenase 13 （17β- HSD13） may promote the development of NAFLD.展开更多
基金supported by the National Natural Science Foundation of China(21803059,22401267)the Training Program for Young Backbone Teachers in Higher Education Institutions of Henan Province(2024GGJS011)the Natural Science Foundation of Henan Province(252300421282)。
文摘Organic fluorescent materials with multistimuli-responsive behaviors have attracted much attention because of their promising applications in diverse fields.Most chromophores exhibit bright emission in either dilute solutions or aggregation states,which inevitably suffer from the aggregation-caused quenching(ACQ)problem or encounter serious energy loss at low concentration.To overcome these limitations,dual-state emissive(DSE)materials with bright emission in both solution and solid states have been developed.However,most DSE materials only involve one or two stimulus-responsive behaviors.Herein,through combining characteristics of imidazopyridine N1 as well as manipulation of electronic structure and intermolecular interaction,DSE molecule TPA-IPBA with four multistimuli-responsive behaviors has been rationally and accurately prepared,which could be easily converted to ACQ(TPA-IPB)and AIE(aggregation-induced emission)(TPA-IPBCN)molecules.Under external stimuli,four types of multistimuli-responsive behaviors have been successfully achieved,including solvatochromism(redshift of 124 nm),mechanofluorochromism(redshift of 6 or 30 nm),reversible tricolor acidichromism(redshift of 148 nm)and solidphase polymorphism with solvent-dependent solid emission(from B-state to G-state,redshift of 52 nm).We explained four types of multistimuli-responsive behaviors in detail through nuclear magnetic resonance spectroscopies,theoretical calculations,single crystal analysis,and PXRD characterization.In addition,on the basis of our biological research on imidazo[1,2-α]-pyridines,we found that TPA-IPBA serves as a fluorescent probe to dynamically detect biological lipid droplets with high co-localization ability(PC=0.95).These results provide new insight into developing DSE materials via a delicate manipulation of molecular structure with acceptor-dependent tunable multistimuli-responsive properties and bioimaging applications.
基金The authors thank Dr. John Zehmer for his critical reading and useful suggestions. This work was supported by the National Natural Science Foundation of China （Grant No. 31100854 and U 1402225）, the Ministry of Science and Technology of China （Grant No. 2016YFA0500100）, the Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions （CIT＆TCD201504086）.
文摘Non-alcoholic fatty liver disease （NAFLD） is an epidemic metabolic condition driven by an underlying lipid homeostasis disorder. The lipid droplet （LD）, the main organelle involved in neutral lipid storage and hydrolysis, is a potential target for NAFLD therapeutic treat- ment. In this review, we summarize recent progress elucidating the connections between LD-associated proteins and NAFLD found by genome-wide association studies （GWAS）, genomic and proteomic studies. Finally, we discuss a possible mechanism by which the protein 17β-hydroxysteroid dehydrogenase 13 （17β- HSD13） may promote the development of NAFLD.
