Two new linear furocoumarins were isolated from Notopterygium incisum using silica gel,gel Sephadex LH-20 column chromatography,and preparative high-performance liquid chromatography.The structures of the new compound...Two new linear furocoumarins were isolated from Notopterygium incisum using silica gel,gel Sephadex LH-20 column chromatography,and preparative high-performance liquid chromatography.The structures of the new compounds were elucidated through analysis of spectroscopic evidence,including data obtained from high-resolution electrospray ionization mass spectrometry(HRESIMS)and nuclear magnetic resonance(NMR).The absolute configurations of Notoprenylate L(1)and Nototerprinol K(2)were further confirmed using electronic circular dichroism(ECD)calculations.Compound 1 demonstrated the ability to inhibit the expression of nitric oxide(NO),a pro-inflammatory factor,in lipopolysaccharide-induced RAW264.7 macrophages at a concentration of 7.5μmol/L,indicating its potential for anti-inflammatory activity.展开更多
Federated Learning(FL)enables joint training over distributed devices without data exchange but is highly vulnerable to attacks by adversaries in the form of model poisoning and malicious update injection.This work pr...Federated Learning(FL)enables joint training over distributed devices without data exchange but is highly vulnerable to attacks by adversaries in the form of model poisoning and malicious update injection.This work proposes Secured-FL,a blockchain-based defensive framework that combines smart contract-based authentication,clustering-driven outlier elimination,and dynamic threshold adjustment to defend against adversarial attacks.The framework was implemented on a private Ethereum network with a Proof-of-Authority consensus algorithm to ensure tamper-resistant and auditable model updates.Large-scale simulation on the Cyber Data dataset,under up to 50%malicious client settings,demonstrates Secured-FL achieves 6%-12%higher accuracy,9%-15%lower latency,and approximately 14%less computational expense compared to the PPSS benchmark framework.Additional tests,including confusion matrices,ROC and Precision-Recall curves,and ablation tests,confirm the interpretability and robustness of the defense.Tests for scalability also show consistent performance up to 500 clients,affirming appropriateness to reasonably large deployments.These results make Secured-FL a feasible,adversarially resilient FL paradigm with promising potential for application in smart cities,medicine,and other mission-critical IoT deployments.展开更多
The growing prevalence of exercise-induced tibial stress fractures demands wearable sensors capable of monitoring dynamic musculoskeletal loads with medical-grade precision.While flexible pressure-sensing insoles show...The growing prevalence of exercise-induced tibial stress fractures demands wearable sensors capable of monitoring dynamic musculoskeletal loads with medical-grade precision.While flexible pressure-sensing insoles show clinical potential,their development has been hindered by the intrinsic trade-off between high sensitivity and full-range linearity(R^(2)>0.99 up to 1 MPa)in conventional designs.Inspired by the tactile sensing mechanism of human skin,where dermal stratification enables wide-range pressure adaptation and ion-channelregulated signaling maintains linear electrical responses,we developed a dual-mechanism flexible iontronic pressure sensor(FIPS).This innovative design synergistically combines two bioinspired components:interdigitated fabric microstructures enabling pressure-proportional contact area expansion(αP1/3)and iontronic film facilitating self-adaptive ion concentration modulation(αP^(2/3)),which together generate a linear capacitance-pressure response(CαP).The FIPS achieves breakthrough performance:242 kPa^(-1)sensitivity with 0.997linearity across 0-1 MPa,yielding a record linear sensing factor(LSF=242,000).The design is validated across various substrates and ionic materials,demonstrating its versatility.Finally,the FIPS-driven design enables a smart insole demonstrating 1.8%error in tibial load assessment during gait analysis,outperforming nonlinear counterparts(6.5%error)in early fracture-risk prediction.The biomimetic design framework establishes a universal approach for developing high-performance linear sensors,establishing generalized principles for medical-grade wearable devices.展开更多
The equivalent linearization method （ELM） is modified to investigate the nonlinear flut- ter system of an airfoil with a cubic damping. After obtaining the linearization quantity of the cubic nonlinearity by the ELM...The equivalent linearization method （ELM） is modified to investigate the nonlinear flut- ter system of an airfoil with a cubic damping. After obtaining the linearization quantity of the cubic nonlinearity by the ELM, an equivalent system can be deduced and then investigated by linear flut- ter analysis methods. Different from the routine procedures of the ELM, the frequency rather than the amplitude of limit cycle oscillation （LCO） is chosen as an active increment to produce bifurca- tion charts. Numerical examples show that this modification makes the ELM much more efficient. Meanwhile, the LCOs obtained by the ELM are in good agreement with numerical solutions. The nonlinear damping can delay the occurrence of secondary bifurcation. On the other hand, it has marginal influence on bifurcation characteristics or LCOs.展开更多
This paper investigates the magnetohydrodynamic （MHD） boundary layer flow of an incompressible upper-convected Maxwell （UCM） fluid over a porous stretching surface. Similarity transformations are used to reduce th...This paper investigates the magnetohydrodynamic （MHD） boundary layer flow of an incompressible upper-convected Maxwell （UCM） fluid over a porous stretching surface. Similarity transformations are used to reduce the governing partial differential equations into a kind of nonlinear ordinary differential equations. The nonlinear prob- lem is solved by using the successive Taylor series linearization method （STSLM）. The computations for velocity components are carried out for the emerging parameters. The numerical values of the skin friction coefficient are presented and analyzed for various parameters of interest in the problem.展开更多
Linearized equations of fluid dynamics of cell two phase flow for one dimensional case are proposed. Based on the equations, an analytic solution is derived, in which the frequency of wave is observed. The frequency f...Linearized equations of fluid dynamics of cell two phase flow for one dimensional case are proposed. Based on the equations, an analytic solution is derived, in which the frequency of wave is observed. The frequency formula consists of all important parameters of the fluid dynamics. In our observation, the group velocity and phase velocity of the motion of wave propagation are explicitly exhibited as well.展开更多
The aim of our work is to formulate and demonstrate the results of the normality, the Lipschitz continuity, of a nonlinear feedback system described by the monotone maximal operators and hemicontinuous, defined on rea...The aim of our work is to formulate and demonstrate the results of the normality, the Lipschitz continuity, of a nonlinear feedback system described by the monotone maximal operators and hemicontinuous, defined on real reflexive Banach spaces, as well as the approximation in a neighborhood of zero, of solutions of a feedback system [A,B] assumed to be non-linear, by solutions of another linear, This approximation allows us to obtain appropriate estimates of the solutions. These estimates have a significant effect on the study of the robust stability and sensitivity of such a system see <a href="#ref1">[1]</a> <a href="#ref2">[2]</a> <a href="#ref3">[3]</a>. We then consider a linear FS <img src="Edit_4629d4d0-bbb2-478d-adde-391efde3d1e0.bmp" alt="" />, and prove that, if <img src="Edit_435aae08-e821-4b4d-99d2-e2a2b47609c1.bmp" alt="" />;<img src="Edit_4fa030bc-1f97-4726-8257-ca8d00657aac.bmp" alt="" /> , with <img src="Edit_63ab4faa-ba40-45fe-8b8a-7a6caef91794.bmp" alt="" />the respective solutions of FS’s [A,B] and <img src="Edit_e78e2e6d-8934-4011-93eb-8b7eb52fa856.bmp" alt="" /> corresponding to the given (u,v) in <img src="Edit_0e18433c-8c7a-454f-8eec-6eb9fb69469a.bmp" alt="" /> . There exists,<img src="Edit_3dcd8afc-8cea-4c06-a920-e4148a5f793e.bmp" alt="" />, positive real constants such that, <img src="Edit_edb88446-3e39-4fe0-865a-114de701e78e.bmp" alt="" />. These results are the subject of theorems 3.1, <span style="font-size:10.0pt;font-family:;" "="">... </span>, 3.3. The proofs of these theorems are based on our lemmas 3.2, <span style="font-size:10.0pt;font-family:;" "="">... </span>, 3.5, devoted according to the hypotheses on A and B, to the existence of the inverse of the operator <em>I+BA</em> and <img src="Edit_2db1326b-cb5b-44cf-8d1f-df22bd6da45f.bmp" alt="" />. The results obtained and demonstrated along this document, present an extension in general Banach space of those in <a href="#ref4">[4]</a> on a Hilbert space <em>H</em> and those in <a href="#ref5">[5]</a> on a extended Hilbert space <img src="Edit_b70ce337-1812-4d4b-ae7d-a24da7e5b3cf.bmp" alt="" />.展开更多
The flexible job shop scheduling problem(FJSP)is commonly encountered in practical manufacturing environments.A product is typically built by assembling multiple jobs during actual manufacturing.AGVs are normally used...The flexible job shop scheduling problem(FJSP)is commonly encountered in practical manufacturing environments.A product is typically built by assembling multiple jobs during actual manufacturing.AGVs are normally used to transport the jobs from the processing shop to the assembly shop,where they are assembled.Therefore,studying the integrated scheduling problem with its processing,transportation,and assembly stages is extremely beneficial and significant.This research studies the three-stage flexible job shop scheduling problem with assembly and AGV transportation(FJSP-T-A),which includes processing jobs,transporting them via AGVs,and assembling them.A mixed integer linear programming(MILP)model is established to obtain optimal solutions.As the MILP model is challenging for solving large-scale problems,a novel co-evolutionary algorithm(NCEA)with two different decoding methods is proposed.In NCEA,a restart operation is developed to improve the diversity of the population,and a multiple crossover strategy is designed to improve the quality of individuals.The validity of the MILP model is proven by analyzing its complexity.The effectiveness of the restart operator,multiple crossovers,and the proposed algorithm is demonstrated by calculating and analyzing the RPI values of each algorithm's results within the time limit and performing a paired t-test on the average values of each algorithm at the 95%confidence level.This paper studies FJSP-T-A by minimizing the makespan for the first time,and presents a MILP model and an NCEA with two different decoding methods.展开更多
文摘Two new linear furocoumarins were isolated from Notopterygium incisum using silica gel,gel Sephadex LH-20 column chromatography,and preparative high-performance liquid chromatography.The structures of the new compounds were elucidated through analysis of spectroscopic evidence,including data obtained from high-resolution electrospray ionization mass spectrometry(HRESIMS)and nuclear magnetic resonance(NMR).The absolute configurations of Notoprenylate L(1)and Nototerprinol K(2)were further confirmed using electronic circular dichroism(ECD)calculations.Compound 1 demonstrated the ability to inhibit the expression of nitric oxide(NO),a pro-inflammatory factor,in lipopolysaccharide-induced RAW264.7 macrophages at a concentration of 7.5μmol/L,indicating its potential for anti-inflammatory activity.
文摘Federated Learning(FL)enables joint training over distributed devices without data exchange but is highly vulnerable to attacks by adversaries in the form of model poisoning and malicious update injection.This work proposes Secured-FL,a blockchain-based defensive framework that combines smart contract-based authentication,clustering-driven outlier elimination,and dynamic threshold adjustment to defend against adversarial attacks.The framework was implemented on a private Ethereum network with a Proof-of-Authority consensus algorithm to ensure tamper-resistant and auditable model updates.Large-scale simulation on the Cyber Data dataset,under up to 50%malicious client settings,demonstrates Secured-FL achieves 6%-12%higher accuracy,9%-15%lower latency,and approximately 14%less computational expense compared to the PPSS benchmark framework.Additional tests,including confusion matrices,ROC and Precision-Recall curves,and ablation tests,confirm the interpretability and robustness of the defense.Tests for scalability also show consistent performance up to 500 clients,affirming appropriateness to reasonably large deployments.These results make Secured-FL a feasible,adversarially resilient FL paradigm with promising potential for application in smart cities,medicine,and other mission-critical IoT deployments.
基金supported by the National Natural Science Foundation of China(NSFC 52175281,52475315)Youth Innovation Promotion Association of CAS(2021382)。
文摘The growing prevalence of exercise-induced tibial stress fractures demands wearable sensors capable of monitoring dynamic musculoskeletal loads with medical-grade precision.While flexible pressure-sensing insoles show clinical potential,their development has been hindered by the intrinsic trade-off between high sensitivity and full-range linearity(R^(2)>0.99 up to 1 MPa)in conventional designs.Inspired by the tactile sensing mechanism of human skin,where dermal stratification enables wide-range pressure adaptation and ion-channelregulated signaling maintains linear electrical responses,we developed a dual-mechanism flexible iontronic pressure sensor(FIPS).This innovative design synergistically combines two bioinspired components:interdigitated fabric microstructures enabling pressure-proportional contact area expansion(αP1/3)and iontronic film facilitating self-adaptive ion concentration modulation(αP^(2/3)),which together generate a linear capacitance-pressure response(CαP).The FIPS achieves breakthrough performance:242 kPa^(-1)sensitivity with 0.997linearity across 0-1 MPa,yielding a record linear sensing factor(LSF=242,000).The design is validated across various substrates and ionic materials,demonstrating its versatility.Finally,the FIPS-driven design enables a smart insole demonstrating 1.8%error in tibial load assessment during gait analysis,outperforming nonlinear counterparts(6.5%error)in early fracture-risk prediction.The biomimetic design framework establishes a universal approach for developing high-performance linear sensors,establishing generalized principles for medical-grade wearable devices.
基金supported by the National Natural Science Foundation of China (Nos.:11002088,11172333,11272361)
文摘The equivalent linearization method （ELM） is modified to investigate the nonlinear flut- ter system of an airfoil with a cubic damping. After obtaining the linearization quantity of the cubic nonlinearity by the ELM, an equivalent system can be deduced and then investigated by linear flut- ter analysis methods. Different from the routine procedures of the ELM, the frequency rather than the amplitude of limit cycle oscillation （LCO） is chosen as an active increment to produce bifurca- tion charts. Numerical examples show that this modification makes the ELM much more efficient. Meanwhile, the LCOs obtained by the ELM are in good agreement with numerical solutions. The nonlinear damping can delay the occurrence of secondary bifurcation. On the other hand, it has marginal influence on bifurcation characteristics or LCOs.
文摘This paper investigates the magnetohydrodynamic （MHD） boundary layer flow of an incompressible upper-convected Maxwell （UCM） fluid over a porous stretching surface. Similarity transformations are used to reduce the governing partial differential equations into a kind of nonlinear ordinary differential equations. The nonlinear prob- lem is solved by using the successive Taylor series linearization method （STSLM）. The computations for velocity components are carried out for the emerging parameters. The numerical values of the skin friction coefficient are presented and analyzed for various parameters of interest in the problem.
基金Supported by the National Natural Science Foundation of China(10672022)
文摘Linearized equations of fluid dynamics of cell two phase flow for one dimensional case are proposed. Based on the equations, an analytic solution is derived, in which the frequency of wave is observed. The frequency formula consists of all important parameters of the fluid dynamics. In our observation, the group velocity and phase velocity of the motion of wave propagation are explicitly exhibited as well.
文摘The aim of our work is to formulate and demonstrate the results of the normality, the Lipschitz continuity, of a nonlinear feedback system described by the monotone maximal operators and hemicontinuous, defined on real reflexive Banach spaces, as well as the approximation in a neighborhood of zero, of solutions of a feedback system [A,B] assumed to be non-linear, by solutions of another linear, This approximation allows us to obtain appropriate estimates of the solutions. These estimates have a significant effect on the study of the robust stability and sensitivity of such a system see <a href="#ref1">[1]</a> <a href="#ref2">[2]</a> <a href="#ref3">[3]</a>. We then consider a linear FS <img src="Edit_4629d4d0-bbb2-478d-adde-391efde3d1e0.bmp" alt="" />, and prove that, if <img src="Edit_435aae08-e821-4b4d-99d2-e2a2b47609c1.bmp" alt="" />;<img src="Edit_4fa030bc-1f97-4726-8257-ca8d00657aac.bmp" alt="" /> , with <img src="Edit_63ab4faa-ba40-45fe-8b8a-7a6caef91794.bmp" alt="" />the respective solutions of FS’s [A,B] and <img src="Edit_e78e2e6d-8934-4011-93eb-8b7eb52fa856.bmp" alt="" /> corresponding to the given (u,v) in <img src="Edit_0e18433c-8c7a-454f-8eec-6eb9fb69469a.bmp" alt="" /> . There exists,<img src="Edit_3dcd8afc-8cea-4c06-a920-e4148a5f793e.bmp" alt="" />, positive real constants such that, <img src="Edit_edb88446-3e39-4fe0-865a-114de701e78e.bmp" alt="" />. These results are the subject of theorems 3.1, <span style="font-size:10.0pt;font-family:;" "="">... </span>, 3.3. The proofs of these theorems are based on our lemmas 3.2, <span style="font-size:10.0pt;font-family:;" "="">... </span>, 3.5, devoted according to the hypotheses on A and B, to the existence of the inverse of the operator <em>I+BA</em> and <img src="Edit_2db1326b-cb5b-44cf-8d1f-df22bd6da45f.bmp" alt="" />. The results obtained and demonstrated along this document, present an extension in general Banach space of those in <a href="#ref4">[4]</a> on a Hilbert space <em>H</em> and those in <a href="#ref5">[5]</a> on a extended Hilbert space <img src="Edit_b70ce337-1812-4d4b-ae7d-a24da7e5b3cf.bmp" alt="" />.
基金Supported by National Natural Science Foundation of China(Grant Nos.52205529 and 62303204)the Youth Innovation Team Program of Shandong Higher Education Institution(Grant No.2023KJ206)the Guangyue Youth Scholar Innovation Talent Program support received from Liaocheng University(Grant No.LCUGYTD2022-03)。
文摘The flexible job shop scheduling problem(FJSP)is commonly encountered in practical manufacturing environments.A product is typically built by assembling multiple jobs during actual manufacturing.AGVs are normally used to transport the jobs from the processing shop to the assembly shop,where they are assembled.Therefore,studying the integrated scheduling problem with its processing,transportation,and assembly stages is extremely beneficial and significant.This research studies the three-stage flexible job shop scheduling problem with assembly and AGV transportation(FJSP-T-A),which includes processing jobs,transporting them via AGVs,and assembling them.A mixed integer linear programming(MILP)model is established to obtain optimal solutions.As the MILP model is challenging for solving large-scale problems,a novel co-evolutionary algorithm(NCEA)with two different decoding methods is proposed.In NCEA,a restart operation is developed to improve the diversity of the population,and a multiple crossover strategy is designed to improve the quality of individuals.The validity of the MILP model is proven by analyzing its complexity.The effectiveness of the restart operator,multiple crossovers,and the proposed algorithm is demonstrated by calculating and analyzing the RPI values of each algorithm's results within the time limit and performing a paired t-test on the average values of each algorithm at the 95%confidence level.This paper studies FJSP-T-A by minimizing the makespan for the first time,and presents a MILP model and an NCEA with two different decoding methods.
