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Numerical studies for plasmas of a linear plasma device HIT-PSI with geometry modified SOLPS-ITER
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作者 王敏 聂秋月 +2 位作者 黄韬 王晓钢 张彦杰 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期503-508,共6页
The HIT-PSI is a linear plasma device built for physically simulating the high heat flux environment of future reactor divertors to test/develop advanced target plate materials.In this study,the geometry-modified SOLP... The HIT-PSI is a linear plasma device built for physically simulating the high heat flux environment of future reactor divertors to test/develop advanced target plate materials.In this study,the geometry-modified SOLPS-ITER program is employed to examine the effects of the magnetic field strength and neutral pressure in the device on the heat flux experienced by the target plate of the HIT-PSI device.The findings of the numerical simulation indicate a positive correlation between the magnetic field strength and the heat flux density.Conversely,there is a negative correlation observed between the heat flux density and the neutral pressure.When the magnetic field strength at the axis exceeds 1 tesla and the neutral pressure falls below 10 Pa,the HIT-PSI has the capability to attain a heat flux of 10 MW·m-2 at the target plate.The simulation results offer a valuable point of reference for subsequent experiments at HIT-PSI. 展开更多
关键词 HIT-PSI heat flux linear plasma SOLPS-ITER device
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Linear Plasma Sources for Large Area Film Deposition:A Brief Review 被引量:1
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作者 魏钰 左潇 +4 位作者 陈龙威 孟月东 方世东 沈洁 舒兴胜 《Plasma Science and Technology》 SCIE EI CAS CSCD 2014年第4期356-362,共7页
By utilization of different excitation power sources, linear plasma sources can be differentiated into DC, RF, VHF, microwave and dual frequency types. Through installing several linear plasma sources in parallel or a... By utilization of different excitation power sources, linear plasma sources can be differentiated into DC, RF, VHF, microwave and dual frequency types. Through installing several linear plasma sources in parallel or adopting the so-called roll-to-roll (air-to-air) process, scale uniform linear plasma sources were realized and successfully applied to the deposition of large area uniform dielectric thin films, Furthermore, the magnetic field system can effectively reduce the recombination losses on the wall of the vacuum chamber and enhance the plasma density. Linear plasma sources with approximately one square meter deposition area with the plasma density of 1011 cm 3 have been developed, some of which have been used for the deposition of dielectric layers and large area plasma etching. 展开更多
关键词 linear plasma sources large area UNIFORM high density
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Experimental investigation on high heat flux plasma parameters of HIT-PSI device in argon discharges
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作者 Tao HUANG Qiuyue NIE +7 位作者 Cheng CHEN Lin NIE Wei ZHAO Tao JIANG Yang LIU Xu ZHAO Feng LI Xiaogang WANG 《Plasma Science and Technology》 2025年第1期118-127,共10页
Researches on plasma-facing materials/components(PFMs/PFCs)have become a focus in magnetic confinement fusion studies,particularly for advanced tokamak operation scenarios.Similarly,spacecraft surface materials must m... Researches on plasma-facing materials/components(PFMs/PFCs)have become a focus in magnetic confinement fusion studies,particularly for advanced tokamak operation scenarios.Similarly,spacecraft surface materials must maintain stable performance under relatively high temperatures and other harsh plasma conditions,making studies of their thermal and ablation resistance critical.Recently,a low-cost,low-energy-storage for superconducting magnets,and compact linear device,HIT-PSI,has been designed and constructed at Harbin Institute of Technology(HIT)to investigate the interaction between stable high heat flux plasma and PFMs/PFCs in scrape-off-layer(SOL)and divertor regions,as well as spacecraft surface materials.The parameters of the argon plasma beam of HIT-PSI are diagnosed using a water-cooled planar Langmuir probe and emission spectroscopy.As magnetic field rises to 2 T,the argon plasma beam generated by a cascaded arc source achieves high density exceeding 1.2×10^(21)m^(-3)at a distance of 25 cm from the source with electron temperature surpassing 4 eV,where the particle flux reaches 10^(24)m^(-2)s^(-1),and the heat flux loaded on the graphite target measured by infrared camera reaches 4 MW/m^(2).Combined with probe and emission spectroscopy data,the transport characteristics of the argon plasma beam are analyzed. 展开更多
关键词 linear plasma device plasma-material interaction high heat flux high particle flux
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Recent studies of tungsten-based plasma-facing materials in the linear plasma device STEP 被引量:4
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作者 Hao Yin Jun Wang +3 位作者 Wangguo Guo Long Cheng Yue Yuan Guanghong Lu 《Tungsten》 2019年第2期132-140,共9页
This contribution summarized the recent studies of tungsten-based plasma-facing materials in the linear plasma device like the simulator for tokamak edge plasma(STEP),focusing on the examination of newly developed tun... This contribution summarized the recent studies of tungsten-based plasma-facing materials in the linear plasma device like the simulator for tokamak edge plasma(STEP),focusing on the examination of newly developed tungsten(W)-based materi-als and plasma-induced defects in pure W.Pure W,W-V,W-Y_(2)O_(3)and W-ZrC samples were exposed to a high-flux plasma of~1021-1022 m^(−2)s^(−1) with a fluence up to 1026 m^(−2) at a surface temperature below 500 K.The investigation of fundamental evolution of plasma-induced defects in pure W indicated a critical role of hydrogen-dislocation interactions.Suppressed surface blistering was observed in all W-based materials,but deuterium desorption behavior and retention were distinct with respect to different materials.The studies showed that the linear plasma device like the STEP was indispensable in the understanding of plasma-material interactions and the qualification of new materials for future fusion reactors. 展开更多
关键词 linear plasma device plasma irradiation TUNGSTEN plasma-facing materials STEP
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Piecewise linear recursive convolution FDTD method for magnetized plasmas 被引量:4
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作者 Liu Song Zhong Shuangying Liu Shaobin 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2006年第2期290-295,共6页
The piecewise linear recursive convolution (PLRC) finite-different time-domain (FDTD) method greatly improves accuracy over the original recursive convolution (RC) FDTD approach but retains its speed and efficie... The piecewise linear recursive convolution (PLRC) finite-different time-domain (FDTD) method greatly improves accuracy over the original recursive convolution (RC) FDTD approach but retains its speed and efficiency advantages. A PLRC-FDTD formulation for magnetized plasma which incorporates both anisotropy and frequency dispersion at the same time is presented, enabled the transient analysis of magnetized plasma media. The technique is illustrated by numerical simulations the reflection and transmission coefficients through a magnetized plasma layer. The results show that the PLRC-FDTD method has significantly improved the accuracy over the original RC method. 展开更多
关键词 electromagnetic wave FDTD methods piecewise linear recursive convolution magnetized plasma.
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Characteristics of a radio-frequency cold atmospheric plasma jet produced with a hybrid cross-linear-field electrode configuration 被引量:1
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作者 Jing LI Heping LI 《Plasma Science and Technology》 SCIE EI CAS CSCD 2019年第5期102-112,共11页
Cold atmospheric plasma(CAP)jet has wide applications in various fields including advanced materials synthesis and modifications,biomedicine,environmental protection and energy saving,etc.Appropriate control on the vo... Cold atmospheric plasma(CAP)jet has wide applications in various fields including advanced materials synthesis and modifications,biomedicine,environmental protection and energy saving,etc.Appropriate control on the volume,temperature and chemically reactive species concentratio ns of the CAP jet is of great importance in actual applications.In this paper,an radio-frequency atmospheric-pressure glow discharge(RF-APGD)plasma generator with a hybrid cross-linear-field electrode configuration is proposed.The experimental results show that,with the aid of the copper mesh located at the downstream of the traditional co-axial-type plasma generator with a cross-field electrode configuration,a linear field between the inner powered electrode of the traditional plasma generator and the copper mesh can be established.This linerfield can,to some extent,enhance the discharges at the upstream of the copper mesh,resulting in small increments(all less than 12.5%)of the species emission intensities,electron excitation temperatures and gas temperatures by keeping other parameters being unchanged.And due to the intrinsic transparent and conducting features of the grounded copper mesh to the gas flowing,electric current and heat flux of the plasma plumes,a plasma region with higher concentrations of chemically reactive species and larger plasma plume diameters is obtained at the downstream of the grounded copper mesh on the same level of the gas temperature and electron excitation temperature compared to those of the plasma free jet.In addition,the charged particle number densities at the same downstream axial location of the grounded copper mesh decrease significantly compared to those of the plasma free jet.This means that the copper mesh is also,to some extent,helpful for separating the chemically reactive neutral species from the charged particles in side a plasma environment.The preceding results indicate that the cross-linear-field electrode configuration of the plasma generator is an effective approach for tuning the characteristics of the RF-APGD plasma jet in order to obtain an appropriate combination of the plasma jet properties with higher chemically reactive species concentrations,especially relative higher number densities of neutral species,larger plasma volumes and lower gas temperatures. 展开更多
关键词 COLD ATMOSPHERIC plasma hybrid-cross-linear-field electrode configuration grounded copper mesh plasma jet CHARACTERISTICS modulation
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An investigation on improving the homogeneity of plasma generated by linear microwave plasma source with a length of 1550 mm
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作者 Jicheng ZHOU Wei XU Techao CHEN 《Plasma Science and Technology》 SCIE EI CAS CSCD 2021年第2期7-16,共10页
To develop a larger in-line plasma enhanced chemical vapor deposition(PECVD)device,the length of the linear microwave plasma source needs to be increased to 1550 mm.This paper proposes a solution to the problem of pla... To develop a larger in-line plasma enhanced chemical vapor deposition(PECVD)device,the length of the linear microwave plasma source needs to be increased to 1550 mm.This paper proposes a solution to the problem of plasma inhomogeneity caused by increasing device length.Based on the COMSOL Multiphysics,a multi-physics field coupling model for in-line PECVD device is developed and validated.The effects of microwave power,chamber pressure,and magnetic flux density on the plasma distribution are investigated,respectively,and their corresponding optimized values are obtained.This paper also presents a new strategy to optimize the wafer position to achieve the balance between deposition rate and film quality.Numerical results have indicated that increasing microwave power and magnetic flux density or decreasing chamber pressure all play positive roles in improving plasma homogeneity,and among them,the microwave power is the most decisive influencing factor.It is found that the plasma homogeneity is optimal under the condition of microwave power at 2000 W,chamber pressure at 15 Pa,and magnetic field strength at 45 mT.The relative deviation is within−3.7%to 3.9%,which fully satisfies the process requirements of the equipment.The best position for the wafer is 88 mm from the copper antenna.The results are very valuable for improving the quality of the in-line PECVD device. 展开更多
关键词 in-line PECVD linear microwave plasma source multi-physics field COMSOL simulation HOMOGENEITY
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A Revised Piecewise Linear Recursive Convolution FDTD Method for Magnetized Plasmas 被引量:1
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作者 刘崧 钟双英 刘少斌 《Plasma Science and Technology》 SCIE EI CAS CSCD 2005年第6期3122-3126,共5页
The piecewise linear recursive convolution (PLRC) finite-different time-domain (FDTD) method improves accuracy over the original recursive convolution (RC) FDTD approach and current density convolution (JEC) b... The piecewise linear recursive convolution (PLRC) finite-different time-domain (FDTD) method improves accuracy over the original recursive convolution (RC) FDTD approach and current density convolution (JEC) but retains their advantages in speed and efficiency. This paper describes a revised piecewise linear recursive convolution PLRC-FDTD formulation for magnetized plasma which incorporates both anisotropy and frequency dispersion at the same time, enabling the transient analysis of magnetized plasma media. The technique is illustrated by numerical simulations of the reflection and transmission coefficients through a magnetized plasma layer. The results show that the revised PLRC-FDTD method has improved the accuracy over the original RC FDTD method and JEC FDTD method. 展开更多
关键词 Electromagnetic wave finite-different time-domain (FDTD) methods piecewise linear recursive convolution magnetized plasma
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Dispersion Relation of Linear Waves in Quantum Magnetoplasmas
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作者 祝俊 《Plasma Science and Technology》 SCIE EI CAS CSCD 2016年第7期703-707,共5页
The quantum magnetohydrodynamic (QMHD) model is applied in investigating the propagation of linear waves in quantum magnetoplasmas. Using the QMHD model, the dispersion equation for quantum magnetoplasmas and the di... The quantum magnetohydrodynamic (QMHD) model is applied in investigating the propagation of linear waves in quantum magnetoplasmas. Using the QMHD model, the dispersion equation for quantum magnetoplasmas and the dispersion relations of linear waves are deduced. Results show that quantum effects affect the propagation of electron plasma waves and extraordinary waves (X waves). When we select the plasma parameters of the laser-based plasma compression (LBPC) schemes for calculation, the quantum correction cannot be neglected. Meanwhile, the corrections produced by the Fermi degeneracy pressure and Bohm potential are compared under different plasma parameter conditions. 展开更多
关键词 quantum plasmas dispersion relation QMHD linear waves
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Onset of Linear Instability in a Complex Plasma with Cairns Distributed Electrons
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作者 I. Habumugisha S. K. Anguma +1 位作者 E. Jurua N. Noreen 《International Journal of Astronomy and Astrophysics》 2016年第1期1-7,共7页
A rigorous theoretical investigation of linear dust ion acoustic (DIA) solitary waves in an unmagnetized complex plasma consisting of ion and ion beam fluids, nonthermal electrons that are Cairns distributed and immob... A rigorous theoretical investigation of linear dust ion acoustic (DIA) solitary waves in an unmagnetized complex plasma consisting of ion and ion beam fluids, nonthermal electrons that are Cairns distributed and immobile dust particles were undertaken. It was found out that, for large beam speeds, three stable modes propagated as solitary waves in the beam plasma. These were the “Fast”, “Slow” and “Ion-acoustic” modes. For two stream instability to occur between ion and ion beam, it is shown that or when . 展开更多
关键词 linear Instability Complex plasma Cairns Distributed Electrons
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利用直线等离子体装置STEP中的朗缪探针测量氘等离子体参数
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作者 程龙 崔家铜 +7 位作者 蒋韫哲 宋汉丰 于倩楠 彭加官 胡地 袁悦 金硕 吕广宏 《物理实验》 2025年第7期1-8,共8页
直线等离子体装置能够产生高于1022 m^(-2)·s^(-1)的高通量等离子体,是模拟聚变堆边界等离子体与材料相互作用的重要实验手段,而朗缪探针是测量等离子体通量等参数的重要技术方法.本文介绍了基于北京航空航天大学直线等离子体装置S... 直线等离子体装置能够产生高于1022 m^(-2)·s^(-1)的高通量等离子体,是模拟聚变堆边界等离子体与材料相互作用的重要实验手段,而朗缪探针是测量等离子体通量等参数的重要技术方法.本文介绍了基于北京航空航天大学直线等离子体装置STEP中朗缪探针系统开展的实验测量工作:基础实验部分,可以完成等离子体的电子温度、电子密度、通量的测量;扩展实验部分,可以获得电子温度、电子密度和通量随磁场、等离子体源等外界参数的变化关系.通过分析上述外界条件和等离子体参数的关系,使学生掌握基于朗缪探针的高通量等离子体参数实验测量方法. 展开更多
关键词 核聚变 直线等离子体 朗缪探针 等离子体与材料相互作用
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微波等离子体线性离子阱质谱测定水中锆元素方法应用研究
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作者 张天睿 王洁 +4 位作者 蒋涛 颜妍 刘春红 朱健铭 崔建勇 《世界核地质科学》 2025年第3期640-646,共7页
微波等离子体炬(MPT)是由国内科研团队研发的新型等离子体激发源,是一种软电离技术,具备常压电离特性,多用于有机物的分析。与电感耦合等离子体(ICP)电离源相比,MPT电离能量低,难将待测元素电离成金属离子,限制了在无机检测领域的应用... 微波等离子体炬(MPT)是由国内科研团队研发的新型等离子体激发源,是一种软电离技术,具备常压电离特性,多用于有机物的分析。与电感耦合等离子体(ICP)电离源相比,MPT电离能量低,难将待测元素电离成金属离子,限制了在无机检测领域的应用。为拓宽MPT源的应用范围,将其与线性离子阱质谱(LTQ-MS)联用,以锆元素为研究对象,建立定量分析方法,应用于环境监测领域。将锆溶液导入MPT-LTQ-MS实验装置,通过气动雾化产生气溶胶,经浓硫酸干燥,干燥后的气溶胶在微波等离子体矩产生的等离子体火焰中形成阴离子,在负离子模式下被LTQ-MS检测,通过碰撞诱导解离实验对锆的质谱图进行分析。实验结果表明:被激发的部分锆离子基本可以确认以[ZrO(NO_(3))_(3)]^(-)的形式存在,该复合阴离子可以作为检测水样中锆的特征信号,并通过多级质谱的特征谱峰进行定量分析。m/z 292的质谱特征信号(^(90)Zr),在5~100μg·L^(-1)浓度区间内,质谱特征峰强度与锆浓度呈现良好的线性相关性(R^(2)=0.998 8),方法检出限(LOD)为2.6μg·L^(-1),精密度(RSD)良好,优于8.9%。采用MPT-LTQ-MS方法测定地表水中锆含量,范围介于0.34~3.22μg·L^(-1)之间,加标回收率介于94%~105%之间。实验结果表明:MPT-LTQ-MS方法可以作为锆元素的一种简便的检测方法,可在环境监控、饮用水检验等方面得到应用。 展开更多
关键词 微波等离子体炬 线性离子阱质谱 负离子模式
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Particle flux characteristics of a compact high-field cascaded arc plasma device
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作者 Xiaogang YUAN Haishan ZHOU +7 位作者 Haodong LIU Bo LI Yong WANG Lei CHANG Xin YANG Chuang WANG Lupeng ZHANG Guangnan LUO 《Plasma Science and Technology》 SCIE EI CAS CSCD 2021年第11期59-65,共7页
A new compact cascaded arc device for plasma-wall interaction study is developed at the Institute of Plasma Physics,Chinese Academy of Sciences.A magnetic field up to 0.8 T is achieved to confine plasmas in a 1.2 m lo... A new compact cascaded arc device for plasma-wall interaction study is developed at the Institute of Plasma Physics,Chinese Academy of Sciences.A magnetic field up to 0.8 T is achieved to confine plasmas in a 1.2 m long and 0.1 m diameter vacuum chamber.Gas fluid type analysis in this compact vacuum system was done under high particle flux condition.The gas pressure obtained by calculation was consistent with the measurement result.Continuous argon plasma discharge with ion flux of~0.5×10^(24)m^(-2)s^(-1)is successfully sustained for more than 1h.The effects of magnetic field configuration,gas flow rate,and discharge arc current on the ion flux to target were studied in detail. 展开更多
关键词 cascaded arc plasma plasma-wall interaction ion flux vacuum design linear plasma device
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血浆纤维蛋白原水平对脓毒性休克患者院内死亡的预测价值
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作者 周力 韩勇 +6 位作者 庞婷 雷景恒 曾珊 王静静 周岳杰 李舒雅 邓哲 《实用医学杂志》 北大核心 2025年第12期1840-1845,共6页
目的探讨脓毒性休克患者血浆纤维蛋白原(fibrinogen,FBG)水平与院内死亡的关系及其预测价值。方法回顾性分析2018年8月1日至2020年12月31日在深圳市第二人民医院ICU诊断为脓毒性休克的563例患者的临床资料。收集患者人口统计学信息,入... 目的探讨脓毒性休克患者血浆纤维蛋白原(fibrinogen,FBG)水平与院内死亡的关系及其预测价值。方法回顾性分析2018年8月1日至2020年12月31日在深圳市第二人民医院ICU诊断为脓毒性休克的563例患者的临床资料。收集患者人口统计学信息,入院时的基本生命体征、血常规和生化指标,并计算急性生理学和慢性健康状况评估Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分。采用二元logistic回归分析探讨血浆FBG与脓毒性休克患者院内死亡的相关性,广义相加模型(generalized additive model,GAM)模型和平滑曲线拟合探讨非线性关系,分段式logistic线性回归进行量化。绘制FBG和APACHEⅡ评分对脓毒性休克患者院内死亡的受试者工作特征曲线(receiver operating characteristic,ROC),计算曲线下面积(area under curve,AUC),比较两者的预测效能。采用亚组分析来探讨不同人群的异质性。结果二元logistic回归分析提示血浆FBG与脓毒性休克患者院内死亡之间存在显著负相关(P<0.05)。GAM模型和平滑曲线拟合确定脓毒性休克患者血浆FBG水平与院内死亡之间存在非线性关系,拐点为5.54 g/L。分段式线性回归模型提示拐点左侧(FBG≤5.54 g/L),血浆FBG每降低1 g/L,死亡风险增加24.5%(OR=0.755,P=0.003);而拐点右侧(FBG>5.54 g/L),两者关系无统计学意义(OR=1.049,P=0.685)。亚组分析结果显示,各亚组特征对FBG与院内死亡之间的关系无修饰作用。结论脓毒性休克患者FBG水平与院内死亡之间存在非线性关系,对脓毒性休克患者院内死亡风险有一定的预测价值。 展开更多
关键词 脓毒性休克 血浆纤维蛋白原 院内死亡 非线性关系
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基于多级碎裂的纸喷雾原位质谱法测定血浆中他克莫司
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作者 潘菲 杨爽 +9 位作者 屈子裕 张谛 王春霞 甄宏斌 叶子弘 戴新华 方向 姜海迪 谢洁 江游 《质谱学报》 北大核心 2025年第4期453-463,共11页
本研究采用自主研制的四极杆-线形离子阱串联质谱系统,建立了纸喷雾原位质谱快速检测血浆中他克莫司的方法。为了缩短检测时间,使用有机溶剂对血浆样本进行沉淀,然后吸取上清液进行检测。由于样品基质复杂,采用他克莫司三级碎裂离子进... 本研究采用自主研制的四极杆-线形离子阱串联质谱系统,建立了纸喷雾原位质谱快速检测血浆中他克莫司的方法。为了缩短检测时间,使用有机溶剂对血浆样本进行沉淀,然后吸取上清液进行检测。由于样品基质复杂,采用他克莫司三级碎裂离子进行定量分析。通过优化纸喷雾离子源和质谱条件,显著提高了检测灵敏度。结果表明,他克莫司在5.00~1 000.00μg/L范围内的线性关系良好,相关系数(R^(2))为0.998,检出限和定量限分别为1.00、5.00μg/L,准确度在95.23%~102.39%之间,日内和日间精密度范围分别为6.17%~11.90%和5.30%~13.39%,基质效应归一化因子(RSD)≤8.88%。采用该方法检测20例血浆样本中他克莫司的含量范围为5.62~36.75μg/L,RSD在1.75%~14.41%之间,表明精密度良好。该方法有望成为一种快速检测血药的替代方案。 展开更多
关键词 纸喷雾原位质谱 四极杆-线形离子阱 三级离子定量分析 他克莫司 血浆
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PDRK:A General Kinetic Dispersion Relation Solver for Magnetized Plasma 被引量:1
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作者 谢华生 肖湧 《Plasma Science and Technology》 SCIE EI CAS CSCD 2016年第2期97-107,共11页
A general,fast,and effective approach is developed for numerical calculation of kinetic plasma linear dispersion relations.The plasma dispersion function is approximated by J-pole expansion.Subsequently,the dispersion... A general,fast,and effective approach is developed for numerical calculation of kinetic plasma linear dispersion relations.The plasma dispersion function is approximated by J-pole expansion.Subsequently,the dispersion relation is transformed to a standard matrix eigenvalue problem of an equivalent linear system.Numerical solutions for the least damped or fastest growing modes using an 8-pole expansion are generally accurate;more strongly damped modes are less accurate,but are less likely to be of physical interest.In contrast to conventional approaches,such as Newton's iterative method,this approach can give either all the solutions in the system or a few solutions around the initial guess.It is also free from convergence problems.The approach is demonstrated for electrostatic dispersion equations with one-dimensional and twodimensional wavevectors,and for electromagnetic kinetic magnetized plasma dispersion relation for bi-Maxwellian distribution with relative parallel velocity flows between species. 展开更多
关键词 plasma physics dispersion relation kinetic waves instabilities linear system matrix eigenvalue
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地榆皂苷Ⅰ在正常和急性肾损伤大鼠体内的药代动力学分析 被引量:1
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作者 张允惠 刘艳丽 +4 位作者 许琼明 孙淑仃 朱泓锦 赵迪 冯素香 《中国实验方剂学杂志》 北大核心 2025年第5期203-210,共8页
目的:基于超高效液相色谱-四极杆-静电场轨道阱-线性离子阱质谱法(UPLC-Orbitrap Fusion Lumos Tribrid-MS),测定口服给药后不同时间点地榆皂苷Ⅰ的血药浓度,对比分析其在正常大鼠与急性肾损伤大鼠体内的药代动力学特征。方法:将48只雄... 目的:基于超高效液相色谱-四极杆-静电场轨道阱-线性离子阱质谱法(UPLC-Orbitrap Fusion Lumos Tribrid-MS),测定口服给药后不同时间点地榆皂苷Ⅰ的血药浓度,对比分析其在正常大鼠与急性肾损伤大鼠体内的药代动力学特征。方法:将48只雄性SD大鼠随机分为正常组和模型组,模型组腹腔注射顺铂(10 mg·kg^(-1))建立急性肾损伤模型,正常组给予等体积生理盐水。造模成功后,正常组及模型组大鼠随机分为正常低、中、高剂量组(2.5、5、7.5 mg·kg^(-1))和模型低、中、高剂量组(2.5、5、7.5 mg·kg^(-1)),每组6只,分别灌胃相应剂量的地榆皂苷Ⅰ后收集不同时间点的血浆,采用UPLC-Orbitrap Fusion Lumos Tribrid-MS测定大鼠血浆中地榆皂苷Ⅰ的质量浓度,绘制药-时曲线,利用Kinetica 5.1软件计算药代动力学参数,以SPSS 22.0进行独立样本t检验比较不同给药组间药代动力学参数的差异。结果:药代动力学结果显示,灌胃不同剂量的地榆皂苷Ⅰ后,其浓度均表现为先增大后减小,且均在0.5 h左右达到最大血药浓度;正常大鼠和模型大鼠药时曲线下面积(AUC_(0-t))、平均滞留时间(MRT_(0-t))随给药剂量增加而增多,清除率(CL)随给药剂量增加而减少。与正常组比较,不同给药剂量下模型组大鼠的AUC_(0-t)均显著增加(P<0.01)、达峰浓度(C_(max))均升高、CL均降低,表明动物的生理状态会影响地榆皂苷Ⅰ在体内的吸收与消除。结论:地榆皂苷Ⅰ在正常大鼠体内和急性肾损伤模型大鼠体内药代动力学特征存在较大差异,可能为病理状态下体内环境变化,进而导致吸收和代谢过程发生变化。 展开更多
关键词 地榆皂苷Ⅰ 急性肾损伤 顺铂 超高效液相色谱-四极杆-静电场轨道阱-线性离子阱质谱法(UPLCOrbitrap Fusion Lumos Tribrid-MS) 血药浓度 药代动力学
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Interactions of Microwave with Plasmas 被引量:1
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作者 张海峰 邵福球 王龙 《Plasma Science and Technology》 SCIE EI CAS CSCD 2003年第3期1773-1778,共6页
When plasma size scale is comparable with the wavelength of electromagnetic waves, W.K.B. solution isn't applicable. In this paper a new numerical solution technique to investigate interactions of microwave with p... When plasma size scale is comparable with the wavelength of electromagnetic waves, W.K.B. solution isn't applicable. In this paper a new numerical solution technique to investigate interactions of microwave with plasmas is presented by using Runge-Kutta method. The results of numerical solution coincide with that of analytical solution while the model is linear electron density profile in calculated accuracy. 展开更多
关键词 MICROWAVE plasma analytical solution numerical solution linear
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The Dispersion Characteristics of a One Dimensional Plasma Photonic Crystal Having Inhomogeneous Plasma Density Profiles
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作者 Surendra Prasad Vivek Singh A. K. Singh 《Optics and Photonics Journal》 2012年第3期222-229,共8页
The dispersion characteristics of binary 1D-PPCs having inhomogeneous plasma in the unit cell are studied. Using the transfer matrix method the required dispersion relations are obtained. Here the linear and exponenti... The dispersion characteristics of binary 1D-PPCs having inhomogeneous plasma in the unit cell are studied. Using the transfer matrix method the required dispersion relations are obtained. Here the linear and exponential plasma density profiles are considered and compared with the homogeneous plasma having uniform density profile. It is observed that the inhomogeneity in plasma layer highly affect dispersion curves. By comparing the dispersion curves obtained in all considered cases, it is found that the widths of band gaps and phase velocities are always larger for exponential density profile than the linear uniform density profiles in the considered frequency range. 展开更多
关键词 plasma PHOTONIC Crystal INHOMOGENEOUS plasma DENSITY Dispersion Characteristics linear plasma DENSITY PROFILE EXPONENTIALLY plasma DENSITY PROFILE
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Experimental Study of Parameters of a Plasma Antenna 被引量:3
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作者 Rajneesh KUMAR Dhiraj BORA 《Plasma Science and Technology》 SCIE EI CAS CSCD 2010年第5期592-600,共9页
A plasma column excited by a surface wave can act as a plasma antenna. Experiments are carried out to study the current and conductivity distributions, field, power patterns, directivity and efficiency of such a plasm... A plasma column excited by a surface wave can act as a plasma antenna. Experiments are carried out to study the current and conductivity distributions, field, power patterns, directivity and efficiency of such a plasma antenna. In addition, an equivalent metallic copper antenna is built up and its antenna parameters are compared with that of the plasma antenna. Our findings indicate that the power content in the harmonics of the plasma antenna is more prominent as compared to the copper antenna (which only generates a fundamental frequency). However, the power patterns for both antennae are quite similar. To provide a more qualitative understanding regarding the generation of harmonics in the field of the plasma antenna, a bi-spectral analysis is performed to study the nonlinear interactions in the current fluctuations. Some specific features of the plasma antenna are investigated in our study, which may enhance the application prospect of the plasma antenna with respect to the conventional metallic antenna. 展开更多
关键词 plasma column antenna parameters plasma antenna metallic copper antenna non-linear interactions
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