With the rapid development of DNA technologies, high throughput genomic data have become a powerful leverage to locate desirable genetic loci associated with traits of importance in various crop species. However, curr...With the rapid development of DNA technologies, high throughput genomic data have become a powerful leverage to locate desirable genetic loci associated with traits of importance in various crop species. However, current genetic association mapping analyses are focused on identifying individual QTLs. This study aimed to identify a set of QTLs or genetic markers, which can capture genetic variability for marker-assisted selection. Selecting a set with k loci that can maximize genetic variation out of high throughput genomic data is a challenging issue. In this study, we proposed an adaptive sequential replacement (ASR) method, which is considered a variant of the sequential replacement (SR) method. Through Monte Carlo simulation and comparing with four other selection methods: exhaustive, SR method, forward, and backward methods we found that the ASR method sustains consistent and repeatable results comparable to the exhaustive method with much reduced computational intensity.展开更多
In recent years, Japan, and especially rural areas have faced the growing problems of debt-ridden local railway lines along with the population decline and aging population. Therefore, it is best to consider the disco...In recent years, Japan, and especially rural areas have faced the growing problems of debt-ridden local railway lines along with the population decline and aging population. Therefore, it is best to consider the discontinuation of local railway lines and introduce replacement buses to secure the transportation methods of the local people especially in rural areas. Based on the above background, targeting local railway lines that may be discontinued in the near future, appropriate bus stops when provided with potential bus stops were selected, the present study proposed a method that introduces routes for railway replacement buses adopting ant colony optimization (ACO). The improved ACO was designed and developed based on the requirements set concerning the route length, number of turns, road width, accessibility of railway lines and zones without bus stops as well as the constraint conditions concerning the route length, number of turns and zones without bus stops. Original road network data were generated and processed adopting a geographic information systems (GIS), and these are used to search for the optimal route for railway replacement buses adopting the improved ACO concerning the 8 zones on the target railway line (JR Kakogawa line). By comparing the improved ACO with Dijkstra’s algorithm, its relevance was verified and areas needing further improvements were revealed.展开更多
High diffraction quality crystals of cucurmosin, a type I ribosome inactivating protein isolated from the sarcocarp of Cucurbita moschata (pumpkin), have been grown under newly optimised conditions. With in-house rota...High diffraction quality crystals of cucurmosin, a type I ribosome inactivating protein isolated from the sarcocarp of Cucurbita moschata (pumpkin), have been grown under newly optimised conditions. With in-house rotating anode X-ray source, these crystals diffract to 1.65 ?resolution which is much higher than that of the previously reported crystals that diffracted only to 3 ?resolution. The crystals belong to space group P212121 with cell parameters a = 41.5, b = 58.4 and c = 99.3 . Molecular replacement studies indicate that the cucurmosin structure is homologous to trichosanthin. The initial structural model has been obtained and the model fitting/ refinement is in progress.展开更多
In recent years,with the continuous improvement of people's health requirements,the awareness of participating in disease diagnosis and treatment has also been constantly enhanced.Patient’s participation has beco...In recent years,with the continuous improvement of people's health requirements,the awareness of participating in disease diagnosis and treatment has also been constantly enhanced.Patient’s participation has become a hot issue in medical care policies and research practices.This article intends to review the research background of patient participation and necessity,status,form,significance and existing problems of total hip replacement patients'participation in health care in order to provide reference for the promotion participation in practice.展开更多
Background Objective To summarize the nursing experience of 9 cases of double-hole thoracoscopic aortic valve replacement.Methods From February 2021 to February 2022,9 patientsdiagnosed with severe aortic valve diseas...Background Objective To summarize the nursing experience of 9 cases of double-hole thoracoscopic aortic valve replacement.Methods From February 2021 to February 2022,9 patientsdiagnosed with severe aortic valve disease were enrolled,including 6 males and 3 females,with an average age(50.89±5.3)years,all of whom used double-hole thoracoscopic aortic valve replacement.Implement targeted surgical nursing plans,strengthen condition monitoring,surgical nursing cooperation,and take effective nursing interventions to urgently respond to intraoperative complications.Results Among the 9 patients,7 patients underwent mechanical valve replacement and 2 patients underwent biovalve replacement,of which 2 patients underwent aortic root enlargement surgery at the same time,and none of the patients underwent intraoperative emergency transfer orthothoracotomy.The extracorporeal bypass time was(137.56±27.99)min,the aortic occlusion time was(95.33±17.96)min,and the surgical survival rate was 100%;All patients had well-placed aortic valves,and 2 had mild(<2 cm2)perivalvular leakage.The postoperative recovery time was short,the ventilation time was 6.13(4.43,19.99)h,of which 8 patients were extubated within24 hours,and the ICU length of stay was(2.68±1.3)days,and no deaths and complications occurred.Conclusion For patients with simple aortic valve disease,double-hole thoracoscopic aortic valve replacement is a safe and effective surgical treatment with good early clinical results.Implement a scientifically based nursing plan during surgery to effectively prevent complications,promote early recovery,and improve the quality of nursing.展开更多
文摘With the rapid development of DNA technologies, high throughput genomic data have become a powerful leverage to locate desirable genetic loci associated with traits of importance in various crop species. However, current genetic association mapping analyses are focused on identifying individual QTLs. This study aimed to identify a set of QTLs or genetic markers, which can capture genetic variability for marker-assisted selection. Selecting a set with k loci that can maximize genetic variation out of high throughput genomic data is a challenging issue. In this study, we proposed an adaptive sequential replacement (ASR) method, which is considered a variant of the sequential replacement (SR) method. Through Monte Carlo simulation and comparing with four other selection methods: exhaustive, SR method, forward, and backward methods we found that the ASR method sustains consistent and repeatable results comparable to the exhaustive method with much reduced computational intensity.
文摘In recent years, Japan, and especially rural areas have faced the growing problems of debt-ridden local railway lines along with the population decline and aging population. Therefore, it is best to consider the discontinuation of local railway lines and introduce replacement buses to secure the transportation methods of the local people especially in rural areas. Based on the above background, targeting local railway lines that may be discontinued in the near future, appropriate bus stops when provided with potential bus stops were selected, the present study proposed a method that introduces routes for railway replacement buses adopting ant colony optimization (ACO). The improved ACO was designed and developed based on the requirements set concerning the route length, number of turns, road width, accessibility of railway lines and zones without bus stops as well as the constraint conditions concerning the route length, number of turns and zones without bus stops. Original road network data were generated and processed adopting a geographic information systems (GIS), and these are used to search for the optimal route for railway replacement buses adopting the improved ACO concerning the 8 zones on the target railway line (JR Kakogawa line). By comparing the improved ACO with Dijkstra’s algorithm, its relevance was verified and areas needing further improvements were revealed.
基金Supported by the National Natural Science Foundation of China (39970872) NSF of Fujian province+1 种基金 and International Cooperation program of Fujian province to the State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Struct
文摘High diffraction quality crystals of cucurmosin, a type I ribosome inactivating protein isolated from the sarcocarp of Cucurbita moschata (pumpkin), have been grown under newly optimised conditions. With in-house rotating anode X-ray source, these crystals diffract to 1.65 ?resolution which is much higher than that of the previously reported crystals that diffracted only to 3 ?resolution. The crystals belong to space group P212121 with cell parameters a = 41.5, b = 58.4 and c = 99.3 . Molecular replacement studies indicate that the cucurmosin structure is homologous to trichosanthin. The initial structural model has been obtained and the model fitting/ refinement is in progress.
文摘In recent years,with the continuous improvement of people's health requirements,the awareness of participating in disease diagnosis and treatment has also been constantly enhanced.Patient’s participation has become a hot issue in medical care policies and research practices.This article intends to review the research background of patient participation and necessity,status,form,significance and existing problems of total hip replacement patients'participation in health care in order to provide reference for the promotion participation in practice.
基金supported by National Key Researchand Development Program of China(No.2022YFC2407406)2022 Stability Support for Innovative Capacity Building of Guangdong Provincial Scientific Research Institutions(No.KD022022015)Science and Technology Program of Guangzhou,China(No.202206010049).
文摘Background Objective To summarize the nursing experience of 9 cases of double-hole thoracoscopic aortic valve replacement.Methods From February 2021 to February 2022,9 patientsdiagnosed with severe aortic valve disease were enrolled,including 6 males and 3 females,with an average age(50.89±5.3)years,all of whom used double-hole thoracoscopic aortic valve replacement.Implement targeted surgical nursing plans,strengthen condition monitoring,surgical nursing cooperation,and take effective nursing interventions to urgently respond to intraoperative complications.Results Among the 9 patients,7 patients underwent mechanical valve replacement and 2 patients underwent biovalve replacement,of which 2 patients underwent aortic root enlargement surgery at the same time,and none of the patients underwent intraoperative emergency transfer orthothoracotomy.The extracorporeal bypass time was(137.56±27.99)min,the aortic occlusion time was(95.33±17.96)min,and the surgical survival rate was 100%;All patients had well-placed aortic valves,and 2 had mild(<2 cm2)perivalvular leakage.The postoperative recovery time was short,the ventilation time was 6.13(4.43,19.99)h,of which 8 patients were extubated within24 hours,and the ICU length of stay was(2.68±1.3)days,and no deaths and complications occurred.Conclusion For patients with simple aortic valve disease,double-hole thoracoscopic aortic valve replacement is a safe and effective surgical treatment with good early clinical results.Implement a scientifically based nursing plan during surgery to effectively prevent complications,promote early recovery,and improve the quality of nursing.
