Objective To investigate the prevalence and possible factors influencing metabolic syndrome in people from Guizhou Province and to explore the predictive value of the fat-to-muscle ratio in diagnosing metabolic syndro...Objective To investigate the prevalence and possible factors influencing metabolic syndrome in people from Guizhou Province and to explore the predictive value of the fat-to-muscle ratio in diagnosing metabolic syndrome. Methods A multistage stratified sampling method was used in this cross-sectional study of 20-80 years old Han and Bouyei populations from Guizhou Province, southwestern China, from October-December 2012. The study included 4,553 cases of metabolic syndrome, that was defined according to 2005 International Diabetes Federation criteria. The receiver operating characteristic curve was used for determining the sensitivity, specificity, and predictive ability of the fat-to-muscle ratio for the diagnosis of metabolic syndrome. Results The age-standardized prevalence of metabolic syndrome was 11.38%（men： 9.76%; women： 12.72%） for Han and 4.78%（men： 4.43%; women： 5.30%） for Bouyei populations. In Guizhou Province, the cut-off value for the men fat-to-muscle ratio was 0.34, the area under the curve was 0.95, and the sensitivity and specificity were 0.94 and 0.85, respectively. The cut-off value for the women fat-to-muscle ratio was 0.55, the area under the curve was 0.91, and the sensitivity and specificity were 0.93 and 0.79, respectively. Conclusion The fat-to-muscle ratio is highly predictive of metabolic syndrome in Guizhou Province, and a useful reference indicator.展开更多
Background: The lifestyle modification remains the fundamental approach for the obesity treatment. The aim of this study is to demonstrate the effect of the multimodal lifestyle intervention on the estimated visceral ...Background: The lifestyle modification remains the fundamental approach for the obesity treatment. The aim of this study is to demonstrate the effect of the multimodal lifestyle intervention on the estimated visceral fat area versus changes in musculoskeletal mass in a cohort of adult men with obesity. Subjects and Methods: A retrospective cohort study in which the file of eighty-two male subjects, aged 20 - 60 years, was studied for three months. Patients had been instructed to follow a balanced-hypocaloric diet, physical activity plan and general advice for combating the unhealthy lifestyle habits through the study period. Those who succeeded to loss > 5% of their body weight were classified as weight loser (WL) group, while others as weight resistant (WR) group. The results of In Body-720 bioelectric impedance analysis were used to report the fat mass (FM), visceral fat area (VFA), skeletal muscle mass (SMM), SMM/VFA ratio, osseous mass (OM), and basal metabolic rate (BMR) before and after the study period. Anthropometric measures, glucose, and lipid profile were also analyzed. Paired t-test was used to detect the significance of change between before and after measures, independent sample t-test was used to compare WL vs. WR groups. Results: There were significant decreases in weight, FM (p 0.05) and VFA (p 0.001), in addition to a significant rise of SMM/VFA ratio (p 0.05), together with insignificant changes of osseous mass, SMM and BMR after 3 months. Additionally, total cholesterol, low-density lipoprotein, and triglycerides were significantly reduced (P 0.05). The percentages of reduction in weight, FM and VFA in WL vs. WR groups were highly significant (p 0.001), while the percentages of change in SMM, SMM/VFA ratio and BMR were significant (p 0.05). Conclusion: Lifestyle modification might be effective in production of positive changes in the body composition of patients with obesity. These changes were more significant in weight losers.展开更多
Modern human has different body proportion from early hominids and great apes.Comparing with others,in general,modern human adults have relatively long lower limb and heavier body weight.Since the lower limbs provide ...Modern human has different body proportion from early hominids and great apes.Comparing with others,in general,modern human adults have relatively long lower limb and heavier body weight.Since the lower limbs provide support to the whole body and play an important role in walking,it is proposed that the ratio of the lower limb to the whole body for modern human could be beneficial to bipedal walking.This study tried to estimate the muscle parameters of the lower limb in walking for the subjects with various body proportions.Using a simplified musculoskeletal model,some muscle parameters of the lower limb,e.g.muscle force,stress,work and power,were estimated for modern human adult,child,AL 288-1(the fossil specimens of Australopithecus afarensis,3.18 million years old)and apes.The results show that with the body proportion modern human adult spends less muscle work and power in walking than other subjects.The results imply that using the cost of transport(i.e.the muscle work of the lower limb per unit of displacement)as the criteria,the early hominids,if their body proportions were structurally similar to AL 288-1,could evolve towards what modern human adult looks like,in order to save energy during bipedal walking.展开更多
Background and Objectives:The effects of muscle meat and vegetable intake on body fat mass remain unclear in the general population.This study aimed to investigate the association of body fat mass and fat distribution...Background and Objectives:The effects of muscle meat and vegetable intake on body fat mass remain unclear in the general population.This study aimed to investigate the association of body fat mass and fat distribution with a muscle meat-vegetable intake(MMV)ratio.Methods and Study Design:In total,29,271 participants aged 18–80 years were recruited from the Shaanxi cohort of the Regional Ethnic Cohort Study in Northwest China.The associations of muscle meat,vegetable and MMV ratio,as the independent variable,with body mass index(BMI),waist circumference,total body fat percentage(TBF)and visceral fat(VF),as dependent variables were evaluated by gender-specific linear regression models.Results:There was 47.9%of men whose MMV ratio was greater than or equal to 1 and this figure was about 35.7%for women.For men,higher muscle meat intake was associated with higher TBF(standardized coefficient[ß],0.508;95%CI,0.187–0.829),higher vegetable intake was associated with lower VF(ß,-0.109;95%CI,-0.206–-0.011),and higher MMV ratio was associated with higher BMI(ß,0.195;95%CI,0.039–0.350)and VF(ß,0.523;95%CI,0.209–0.838).For women,both higher muscle meat consumption and MMV ratio were associated with all fat mass markers,but vegetable intake was not correlated with body fat mass markers.The positive association of MMV on body fat mass was more pronounced in higher MMV ratio group,with both men and women.The intake of pork,mutton and beef was associated positively with fat mass markers but no such association was observed for poultry or seafood.Conclusions:An increased intake of muscle meat or a higher MMV ratio was associated with increased body fat,especially among women,and such impact may mainly be attributed to increasing intake of pork,beef and mutton.The dietary MMV ratio could be thus a useful parameter for nutritional intervention.展开更多
目的探讨人体脂肪分布与颈动脉粥样硬化的相关性。方法以2020年1月—2023年1月于北京协和医院国际医疗部(西单院区)健康管理中心体检的成年健康人群为研究对象。收集其基线资料、实验室指标、Inbody人体成分分析及颈动脉超声检查结果。...目的探讨人体脂肪分布与颈动脉粥样硬化的相关性。方法以2020年1月—2023年1月于北京协和医院国际医疗部(西单院区)健康管理中心体检的成年健康人群为研究对象。收集其基线资料、实验室指标、Inbody人体成分分析及颈动脉超声检查结果。根据颈动脉超声检查结果将研究对象分为颈动脉粥样硬化组和对照组。比较两组基线资料、实验室指标及人体成分差异,并采用多元Logistic回归分析探究颈动脉粥样硬化与人体成分的相关性。为进一步探究脂肪分布与颈动脉粥样硬化的相关性,根据四分位数(Q1~Q4)将躯干脂肪与四肢脂肪的比值(躯干脂肪/四肢脂肪)、内脏脂肪面积、腰臀比进一步分为Q1组、Q2组、Q3组和Q4组(以Q1组为参照)。绘制森林图分析各亚组发生颈动脉粥样硬化的风险。结果本研究共纳入2221名受试者,其中男性1194名(53.76%),女性1027名(46.24%),平均年龄(50.28±10.93)岁。颈动脉粥样硬化组1049名,对照组1172名。基线资料分析结果显示,颈动脉粥样硬化组年龄、男性占比高于对照组(P均<0.001);颈动脉粥样硬化组体重、体质量指数(body mass index,BMI)、腰臀比、体脂肪量、躯干脂肪、躯干脂肪/四肢脂肪、内脏脂肪面积等指标均显著高于对照组(P均<0.05)。实验室检查结果显示,颈动脉粥样硬化组血糖、糖化血红蛋白、甘油三酯、尿酸等水平均显著高于对照组(P均<0.001)。多元Logistic回归分析结果显示,调整年龄、性别、吸烟史和饮酒史后,躯干脂肪/四肢脂肪、腰臀比均与颈动脉粥样硬化发生风险显著相关(P均<0.05)。与Q1组比较,Q4组动脉粥样硬化风险显著增加(OR=1.81,95%CI:1.26~2.61,P<0.05);腰臀比、内脏脂肪面积与颈动脉粥样硬化无显著相关性(P>0.05)。结论躯干脂肪/四肢脂肪与颈动脉粥样硬化的发生具有显著相关性。未来应扩大样本量并采用更精确的脂肪分布测量方法以验证本研究结论。展开更多
目的探讨老年2型糖尿病(type 2 diabetes mellitus,T2DM)患者骨骼肌质量与内脏脂肪面积比值(skeletal muscle mass to visceral fat area ratio,SVR)和心血管疾病(cardiovascular disease,CVD)风险之间的关系。方法选取2022年10月至2023...目的探讨老年2型糖尿病(type 2 diabetes mellitus,T2DM)患者骨骼肌质量与内脏脂肪面积比值(skeletal muscle mass to visceral fat area ratio,SVR)和心血管疾病(cardiovascular disease,CVD)风险之间的关系。方法选取2022年10月至2023年12月于苏州大学附属第一医院老年医学科就诊的144例T2DM患者,根据生物电阻抗测量对SVR进行评估。应用中国动脉粥样硬化性心血管疾病风险预测研究(prediction for ASCVD risk in China,China-PAR)风险模型对T2DM患者的心血管病风险进行评估。统计分析SVR与China-PAR风险评分之间的相关性。结果T2DM患者CVD风险评分随SVR的降低而升高(P<0.001)。高危组患者的SVR低于低危组,腰围高于低危组,差异有统计学意义(P<0.05)。两组患者的BMI比较差异无统计学意义(P=0.1229)。在校正混杂因素后,SVR与China-PAR风险评分之间存在独立相关性(β=-2.744,P=0.007)。结论SVR较低的T2DM患者患CVD的风险更高,SVR水平与老年T2DM患者CVD风险呈显著负相关,SVR可能是评估老年CVD风险的有价值的参数。展开更多
基金the National Science and Technology Pillar Program during the Twelfth Five-Year Plan Period sponsored by the Ministry of Science and Technology of China[grant number 2012BAI37B02]the National Natural Science Foundation of China[grant number 81673184]
文摘Objective To investigate the prevalence and possible factors influencing metabolic syndrome in people from Guizhou Province and to explore the predictive value of the fat-to-muscle ratio in diagnosing metabolic syndrome. Methods A multistage stratified sampling method was used in this cross-sectional study of 20-80 years old Han and Bouyei populations from Guizhou Province, southwestern China, from October-December 2012. The study included 4,553 cases of metabolic syndrome, that was defined according to 2005 International Diabetes Federation criteria. The receiver operating characteristic curve was used for determining the sensitivity, specificity, and predictive ability of the fat-to-muscle ratio for the diagnosis of metabolic syndrome. Results The age-standardized prevalence of metabolic syndrome was 11.38%（men： 9.76%; women： 12.72%） for Han and 4.78%（men： 4.43%; women： 5.30%） for Bouyei populations. In Guizhou Province, the cut-off value for the men fat-to-muscle ratio was 0.34, the area under the curve was 0.95, and the sensitivity and specificity were 0.94 and 0.85, respectively. The cut-off value for the women fat-to-muscle ratio was 0.55, the area under the curve was 0.91, and the sensitivity and specificity were 0.93 and 0.79, respectively. Conclusion The fat-to-muscle ratio is highly predictive of metabolic syndrome in Guizhou Province, and a useful reference indicator.
文摘Background: The lifestyle modification remains the fundamental approach for the obesity treatment. The aim of this study is to demonstrate the effect of the multimodal lifestyle intervention on the estimated visceral fat area versus changes in musculoskeletal mass in a cohort of adult men with obesity. Subjects and Methods: A retrospective cohort study in which the file of eighty-two male subjects, aged 20 - 60 years, was studied for three months. Patients had been instructed to follow a balanced-hypocaloric diet, physical activity plan and general advice for combating the unhealthy lifestyle habits through the study period. Those who succeeded to loss > 5% of their body weight were classified as weight loser (WL) group, while others as weight resistant (WR) group. The results of In Body-720 bioelectric impedance analysis were used to report the fat mass (FM), visceral fat area (VFA), skeletal muscle mass (SMM), SMM/VFA ratio, osseous mass (OM), and basal metabolic rate (BMR) before and after the study period. Anthropometric measures, glucose, and lipid profile were also analyzed. Paired t-test was used to detect the significance of change between before and after measures, independent sample t-test was used to compare WL vs. WR groups. Results: There were significant decreases in weight, FM (p 0.05) and VFA (p 0.001), in addition to a significant rise of SMM/VFA ratio (p 0.05), together with insignificant changes of osseous mass, SMM and BMR after 3 months. Additionally, total cholesterol, low-density lipoprotein, and triglycerides were significantly reduced (P 0.05). The percentages of reduction in weight, FM and VFA in WL vs. WR groups were highly significant (p 0.001), while the percentages of change in SMM, SMM/VFA ratio and BMR were significant (p 0.05). Conclusion: Lifestyle modification might be effective in production of positive changes in the body composition of patients with obesity. These changes were more significant in weight losers.
基金Supported in part by the grants fromthe BiotechnologyBiological Sciences Research Council,the Leverhulme Trustthe Natural Environment Research Council,U.K.
文摘Modern human has different body proportion from early hominids and great apes.Comparing with others,in general,modern human adults have relatively long lower limb and heavier body weight.Since the lower limbs provide support to the whole body and play an important role in walking,it is proposed that the ratio of the lower limb to the whole body for modern human could be beneficial to bipedal walking.This study tried to estimate the muscle parameters of the lower limb in walking for the subjects with various body proportions.Using a simplified musculoskeletal model,some muscle parameters of the lower limb,e.g.muscle force,stress,work and power,were estimated for modern human adult,child,AL 288-1(the fossil specimens of Australopithecus afarensis,3.18 million years old)and apes.The results show that with the body proportion modern human adult spends less muscle work and power in walking than other subjects.The results imply that using the cost of transport(i.e.the muscle work of the lower limb per unit of displacement)as the criteria,the early hominids,if their body proportions were structurally similar to AL 288-1,could evolve towards what modern human adult looks like,in order to save energy during bipedal walking.
基金supported by the National Key Research and Development Program of China[grant numbers 2017YFC0907200,2017YFC0907201,2017YFC0907202,2017YFC0907203,2017YFC0907204,and 2017YFC0907205].
文摘Background and Objectives:The effects of muscle meat and vegetable intake on body fat mass remain unclear in the general population.This study aimed to investigate the association of body fat mass and fat distribution with a muscle meat-vegetable intake(MMV)ratio.Methods and Study Design:In total,29,271 participants aged 18–80 years were recruited from the Shaanxi cohort of the Regional Ethnic Cohort Study in Northwest China.The associations of muscle meat,vegetable and MMV ratio,as the independent variable,with body mass index(BMI),waist circumference,total body fat percentage(TBF)and visceral fat(VF),as dependent variables were evaluated by gender-specific linear regression models.Results:There was 47.9%of men whose MMV ratio was greater than or equal to 1 and this figure was about 35.7%for women.For men,higher muscle meat intake was associated with higher TBF(standardized coefficient[ß],0.508;95%CI,0.187–0.829),higher vegetable intake was associated with lower VF(ß,-0.109;95%CI,-0.206–-0.011),and higher MMV ratio was associated with higher BMI(ß,0.195;95%CI,0.039–0.350)and VF(ß,0.523;95%CI,0.209–0.838).For women,both higher muscle meat consumption and MMV ratio were associated with all fat mass markers,but vegetable intake was not correlated with body fat mass markers.The positive association of MMV on body fat mass was more pronounced in higher MMV ratio group,with both men and women.The intake of pork,mutton and beef was associated positively with fat mass markers but no such association was observed for poultry or seafood.Conclusions:An increased intake of muscle meat or a higher MMV ratio was associated with increased body fat,especially among women,and such impact may mainly be attributed to increasing intake of pork,beef and mutton.The dietary MMV ratio could be thus a useful parameter for nutritional intervention.
文摘目的探讨人体脂肪分布与颈动脉粥样硬化的相关性。方法以2020年1月—2023年1月于北京协和医院国际医疗部(西单院区)健康管理中心体检的成年健康人群为研究对象。收集其基线资料、实验室指标、Inbody人体成分分析及颈动脉超声检查结果。根据颈动脉超声检查结果将研究对象分为颈动脉粥样硬化组和对照组。比较两组基线资料、实验室指标及人体成分差异,并采用多元Logistic回归分析探究颈动脉粥样硬化与人体成分的相关性。为进一步探究脂肪分布与颈动脉粥样硬化的相关性,根据四分位数(Q1~Q4)将躯干脂肪与四肢脂肪的比值(躯干脂肪/四肢脂肪)、内脏脂肪面积、腰臀比进一步分为Q1组、Q2组、Q3组和Q4组(以Q1组为参照)。绘制森林图分析各亚组发生颈动脉粥样硬化的风险。结果本研究共纳入2221名受试者,其中男性1194名(53.76%),女性1027名(46.24%),平均年龄(50.28±10.93)岁。颈动脉粥样硬化组1049名,对照组1172名。基线资料分析结果显示,颈动脉粥样硬化组年龄、男性占比高于对照组(P均<0.001);颈动脉粥样硬化组体重、体质量指数(body mass index,BMI)、腰臀比、体脂肪量、躯干脂肪、躯干脂肪/四肢脂肪、内脏脂肪面积等指标均显著高于对照组(P均<0.05)。实验室检查结果显示,颈动脉粥样硬化组血糖、糖化血红蛋白、甘油三酯、尿酸等水平均显著高于对照组(P均<0.001)。多元Logistic回归分析结果显示,调整年龄、性别、吸烟史和饮酒史后,躯干脂肪/四肢脂肪、腰臀比均与颈动脉粥样硬化发生风险显著相关(P均<0.05)。与Q1组比较,Q4组动脉粥样硬化风险显著增加(OR=1.81,95%CI:1.26~2.61,P<0.05);腰臀比、内脏脂肪面积与颈动脉粥样硬化无显著相关性(P>0.05)。结论躯干脂肪/四肢脂肪与颈动脉粥样硬化的发生具有显著相关性。未来应扩大样本量并采用更精确的脂肪分布测量方法以验证本研究结论。
文摘目的探讨老年2型糖尿病(type 2 diabetes mellitus,T2DM)患者骨骼肌质量与内脏脂肪面积比值(skeletal muscle mass to visceral fat area ratio,SVR)和心血管疾病(cardiovascular disease,CVD)风险之间的关系。方法选取2022年10月至2023年12月于苏州大学附属第一医院老年医学科就诊的144例T2DM患者,根据生物电阻抗测量对SVR进行评估。应用中国动脉粥样硬化性心血管疾病风险预测研究(prediction for ASCVD risk in China,China-PAR)风险模型对T2DM患者的心血管病风险进行评估。统计分析SVR与China-PAR风险评分之间的相关性。结果T2DM患者CVD风险评分随SVR的降低而升高(P<0.001)。高危组患者的SVR低于低危组,腰围高于低危组,差异有统计学意义(P<0.05)。两组患者的BMI比较差异无统计学意义(P=0.1229)。在校正混杂因素后,SVR与China-PAR风险评分之间存在独立相关性(β=-2.744,P=0.007)。结论SVR较低的T2DM患者患CVD的风险更高,SVR水平与老年T2DM患者CVD风险呈显著负相关,SVR可能是评估老年CVD风险的有价值的参数。
