Objective To investigate the efficacy of lightroom therapy on depressive mood and sleep problemssin patients with depression,and the potential effects on physiological indices related to circadian rhythms.Methods From...Objective To investigate the efficacy of lightroom therapy on depressive mood and sleep problemssin patients with depression,and the potential effects on physiological indices related to circadian rhythms.Methods From October 2021 to July 2023,54 patients with acute-phase depression hospitalized in the Mental Health Center of the First Hospital of Hebei Medical Universityywererecruited.Theparticipants were randomly assigned to either medication combined with the bright light therapy group(bright light group,n=36)or medication combined with the dim light therapy group(dim light group,n=18).Both groups received light therapy for 2 weeks,at 10000 lx in the bright light group and 300 Ix in the dim light group.Both groups received 30 minutes of light therapy from 7:30-8:00 a.m daily over two weeks,followed up for 1 week posttreatment.TThe Hamilton Depression Rating Scale(HAMDi7)was used to assess patients'depressive symptoms,and the Pittsburgh Sleep Quality Index(PSQI)was used to assess patients’sleep quality at baseline,at the end of every week.The 32-Item Hypomania Checklist(HCL-32)was used at the end of week 2 to assess the risk of manic switching after treatment.Daily measurements of body temperature,heart rate,and blood pressure were taken before and after light therapy,along with recording adverse events related to the therapy.Paired t-tests were used to compare changes in physiological indicators before and after treatment,and repeated measures ANOVA was applied to compare clinical symptom changes between the two groups.Results Thirty-one and fifteen patients completed this study in the bright light and dim light groups,respectively,with no statistically significant difference in dropout rates(P>0.05).There were significant interaction effects between the time and group for HAMD_(17) and PSQI score(F=5.51,4.11,both P<0.05).Both groups showed significant reductions in HAMD_(17) and PSQI scores at baseline,week 1,week 2,and week 3(P<0.001).In the bright light group,body temperature increased significantly post-treatment on days 1-4,day 7,and day 12(all P<0.05).Heart rate elevated on day 5(P<0.05).Systolic blood pressure decreased on days 4,5,11,and 12 compared to the pre-treatment baseline(all P<0.05).In the dim light group,systolic blood pressure increased on day 11(P<0.05).Diastolic blood pressure in the bright light group decreased on days 1,5,and 6(P<0.05).No serious adverse events,vision loss,ocular structural changes occurred in either group.No hypomania or mania episodes were observed.The incidence of adverse events did not differ significantly(P>0.05).Conclusion Medication combined with indoor bright light is more effective than the combination of dim light for depressive symptomssandsleepproblems inpatients with depression.Patients receiving bright light alsomay exhibit a higher body temperature,accelerated heart rate,and reduced blood pressure.展开更多
文摘Objective To investigate the efficacy of lightroom therapy on depressive mood and sleep problemssin patients with depression,and the potential effects on physiological indices related to circadian rhythms.Methods From October 2021 to July 2023,54 patients with acute-phase depression hospitalized in the Mental Health Center of the First Hospital of Hebei Medical Universityywererecruited.Theparticipants were randomly assigned to either medication combined with the bright light therapy group(bright light group,n=36)or medication combined with the dim light therapy group(dim light group,n=18).Both groups received light therapy for 2 weeks,at 10000 lx in the bright light group and 300 Ix in the dim light group.Both groups received 30 minutes of light therapy from 7:30-8:00 a.m daily over two weeks,followed up for 1 week posttreatment.TThe Hamilton Depression Rating Scale(HAMDi7)was used to assess patients'depressive symptoms,and the Pittsburgh Sleep Quality Index(PSQI)was used to assess patients’sleep quality at baseline,at the end of every week.The 32-Item Hypomania Checklist(HCL-32)was used at the end of week 2 to assess the risk of manic switching after treatment.Daily measurements of body temperature,heart rate,and blood pressure were taken before and after light therapy,along with recording adverse events related to the therapy.Paired t-tests were used to compare changes in physiological indicators before and after treatment,and repeated measures ANOVA was applied to compare clinical symptom changes between the two groups.Results Thirty-one and fifteen patients completed this study in the bright light and dim light groups,respectively,with no statistically significant difference in dropout rates(P>0.05).There were significant interaction effects between the time and group for HAMD_(17) and PSQI score(F=5.51,4.11,both P<0.05).Both groups showed significant reductions in HAMD_(17) and PSQI scores at baseline,week 1,week 2,and week 3(P<0.001).In the bright light group,body temperature increased significantly post-treatment on days 1-4,day 7,and day 12(all P<0.05).Heart rate elevated on day 5(P<0.05).Systolic blood pressure decreased on days 4,5,11,and 12 compared to the pre-treatment baseline(all P<0.05).In the dim light group,systolic blood pressure increased on day 11(P<0.05).Diastolic blood pressure in the bright light group decreased on days 1,5,and 6(P<0.05).No serious adverse events,vision loss,ocular structural changes occurred in either group.No hypomania or mania episodes were observed.The incidence of adverse events did not differ significantly(P>0.05).Conclusion Medication combined with indoor bright light is more effective than the combination of dim light for depressive symptomssandsleepproblems inpatients with depression.Patients receiving bright light alsomay exhibit a higher body temperature,accelerated heart rate,and reduced blood pressure.
