1《The Unbearable Lightness of Being》简介
《The Unbearable Lightness of Being》是捷克作家米兰·昆德拉的作品，发表于1984年。其被我国读者所了解应在1987年韩少功和韩刚合译该书之后。自此，专家学者们对小说又有了一系...1《The Unbearable Lightness of Being》简介
《The Unbearable Lightness of Being》是捷克作家米兰·昆德拉的作品，发表于1984年。其被我国读者所了解应在1987年韩少功和韩刚合译该书之后。自此，专家学者们对小说又有了一系列的重译和解读。本文讨论所使用的是Michael Henry Heim所翻译的英文电子版.展开更多
A perceptual lightness anchoring model based on visual cognition is proposed. It can recover absolute lightness of natural images using filling-in mechanism from single-scale boundaries. First, it adapts the response ...A perceptual lightness anchoring model based on visual cognition is proposed. It can recover absolute lightness of natural images using filling-in mechanism from single-scale boundaries. First, it adapts the response of retinal photoreceptors to varying levels of illumination. Then luminance-correlated contrast information can be obtained through multiplex encoding without additional luminance channel. Dynamic normalization is used to get smooth and continuous boundary contours. Different boundaries are used for ON and OFF channel diffusion layers. Theoretical analysis and simulation results indicate that the model could recover natural images under varying illumination, and solve the trapping, blurring and fogging problems to some extent.展开更多
This paper proposed a new algorithm to separate leukocytes from cytological image by setting parameters of lightness transformation based on the RGB color space, which can make the targets’ color in different areas. ...This paper proposed a new algorithm to separate leukocytes from cytological image by setting parameters of lightness transformation based on the RGB color space, which can make the targets’ color in different areas. In our procedure, an operator is employed in using color features. According to their histogram distribution of hue component in HSL color space after enhancing the contrast of image in RGB color space, the threshold of segmentation between leukocyte and erythrocyte could be achieved well. Especially, this algorithm is more efficient than monochrome for leukocyte segmentation, and the results of experiments show that it provides a good tool for cytological image, which can increase accuracy of segmentation of leukocyte.展开更多
Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewa...Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.展开更多
Cellulose frameworks have emerged as promising materials for light management due to their exceptional light-scattering capabilities and sustainable nature.Conventional biomass-derived cellulose frameworks face a fund...Cellulose frameworks have emerged as promising materials for light management due to their exceptional light-scattering capabilities and sustainable nature.Conventional biomass-derived cellulose frameworks face a fundamental trade-off between haze and transparency,coupled with impractical thicknesses(≥1 mm).Inspired by squid’s skin-peeling mechanism,this work develops a peroxyformic acid(HCOOOH)-enabled precision peeling strategy to isolate intact 10-μm-thick bamboo green(BG)frameworks—100×thinner than wood-based counterparts while achieving an unprecedented optical performance(88%haze with 80%transparency).This performance surpasses delignified biomass(transparency<40%at 1 mm)and matches engineered cellulose composites,yet requires no energy-intensive nanofibrillation.The preserved native cellulose I crystalline structure(64.76%crystallinity)and wax-coated uniaxial fibril alignment(Hermans factor:0.23)contribute to high mechanical strength(903 MPa modulus)and broadband light scattering.As a light-management layer in polycrystalline silicon solar cells,the BG framework boosts photoelectric conversion efficiency by 0.41%absolute(18.74%→19.15%),outperforming synthetic anti-reflective coatings.The work establishes a scalable,waste-to-wealth route for optical-grade cellulose materials in next-generation optoelectronics.展开更多
Mise en abyme, according to Gregory Minissale's definition, is "a process of representation within representation". It is a narrative technique characterised by eternal extension of repetitive images. Un...Mise en abyme, according to Gregory Minissale's definition, is "a process of representation within representation". It is a narrative technique characterised by eternal extension of repetitive images. Under Paul Ricoeur's framework of narrative-metaphor analogy, mise en abyme can be regarded not as a blank intertextuality, but as an allegorical infinity structurally performed by textual arrangement. Following his discussion, it is important to explore the functions of allegory from the connection of text and reality to the integration of different elements of text, such as plots, rhetoric usage, ideas, personal characters, etc. As both narrative and the reality imitated by narrative are bound with time, the temporality of mise en abyme enables narrative to be more internally referable. This referability is significant to understand how narrative constitutes reader reception. Structured with this central idea, this paper examines Nietzsche's "eternal recurrence" mentioned in Milan Kundera's novel The Unbearable Lightness of Being and the Sisyphusian life mode in the enclosed communist countryside shown in Ah Cheng's novella "The King of Children".展开更多
Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss.Ferroptosis has been demonstrated to be associated with retinal deg...Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss.Ferroptosis has been demonstrated to be associated with retinal degenerative diseases.However,the molecular mechanisms underlying ferroptosis and photoreceptor cell death in age-related macular degeneration remain largely unexplored.Bioinformatics and biochemical analyses in this study revealed xC^(–),solute carrier family 7 member 11-regulated ferroptosis as the predominant pathological process of photoreceptor cell degeneration in a light-induced dry age-related macular degeneration mouse model.This process involves the nuclear factor-erythroid factor 2-related factor 2-solute carrier family 7 member 11-glutathione peroxidase 4 signaling pathway,through which cystine depletion,iron ion accumulation,and enhanced lipid peroxidation ultimately lead to photoreceptor cell death and subsequent visual function impairment.We demonstrated that solute carrier family 7 member 11 overexpression blocked this process by inhibiting oxidative stress in vitro and in vivo.Conversely,solute carrier family 7 member 11 knockdown or the solute carrier family 7 member 11 inhibitor sulfasalazine and ferroptosis-inducing agent erastin aggravated H_(2)O_(2)-induced ferroptosis of 661W cells.These findings indicate solute carrier family 7 member 11 may be a potential therapeutic target for patients with retinal degenerative diseases including age-related macular degeneration.展开更多
Biti’s is one of the largest footwear manufacturers in Vietnam.Made from homegrown high-quality natural rubber,Biti’s slippers are known for their slip-resistance,durability,lightness,and breathability.In addition t...Biti’s is one of the largest footwear manufacturers in Vietnam.Made from homegrown high-quality natural rubber,Biti’s slippers are known for their slip-resistance,durability,lightness,and breathability.In addition to practicality and comfort,the products come in diverse styles at affordable prices.展开更多
The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically revie...The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically reviewed.Here,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion injury.We further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple mechanisms.Inhibition of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.展开更多
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely limited.The principal pathological alterations of the disease include the selective d...Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely limited.The principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial cells.The biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even urine.Among these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and muscles.Neurofilament light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and sensitivity.However,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal injury.Glial fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration rate.TAR DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related research.Evidence is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease prognosis.Despite the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable challenge.This review summarizes the latest research achievements concerning blood biomarkers in amyotrophic lateral sclerosis that can provide a more direct basis for the differential diagnosis and prognostic assessment of the disease beyond a reliance on clinical manifestations and electromyography findings.展开更多
Glucose molecules are of great significance being one of the most important molecules in metabolic chain.However,due to the small Raman scattering cross-section and weak/non-adsorption on bare metals,accurately obtain...Glucose molecules are of great significance being one of the most important molecules in metabolic chain.However,due to the small Raman scattering cross-section and weak/non-adsorption on bare metals,accurately obtaining their"fingerprint information"remains a huge obstacle.Herein,we developed a tip-enhanced Raman scattering(TERS)technique to address this challenge.Adopting an optical fiber radial vector mode internally illuminates the plasmonic fiber tip to effectively suppress the background noise while generating a strong electric-field enhanced tip hotspot.Furthermore,the tip hotspot approaching the glucose molecules was manipulated via the shear-force feedback to provide more freedom for selecting substrates.Consequently,our TERS technique achieves the visualization of all Raman modes of glucose molecules within spectral window of 400-3200 cm^(-1),which is not achievable through the far-field/surface-enhanced Raman,or the existing TERS techniques.Our TERS technique offers a powerful tool for accurately identifying Raman scattering of molecules,paving the way for biomolecular analysis.展开更多
Carbon emissions resulting from energy consumption have become a pressing issue for governments worldwide.Accurate estimation of carbon emissions using satellite remote sensing data has become a crucial research probl...Carbon emissions resulting from energy consumption have become a pressing issue for governments worldwide.Accurate estimation of carbon emissions using satellite remote sensing data has become a crucial research problem.Previous studies relied on statistical regression models that failed to capture the complex nonlinear relationships between carbon emissions and characteristic variables.In this study,we propose a machine learning algorithm for carbon emissions,a Bayesian optimized XGboost regression model,using multi-year energy carbon emission data and nighttime lights(NTL)remote sensing data from Shaanxi Province,China.Our results demonstrate that the XGboost algorithm outperforms linear regression and four other machine learning models,with an R^(2)of 0.906 and RMSE of 5.687.We observe an annual increase in carbon emissions,with high-emission counties primarily concentrated in northern and central Shaanxi Province,displaying a shift from discrete,sporadic points to contiguous,extended spatial distribution.Spatial autocorrelation clustering reveals predominantly high-high and low-low clustering patterns,with economically developed counties showing high-emission clustering and economically relatively backward counties displaying low-emission clustering.Our findings show that the use of NTL data and the XGboost algorithm can estimate and predict carbon emissionsmore accurately and provide a complementary reference for satellite remote sensing image data to serve carbon emission monitoring and assessment.This research provides an important theoretical basis for formulating practical carbon emission reduction policies and contributes to the development of techniques for accurate carbon emission estimation using remote sensing data.展开更多
The unmanned aerial vehicle(UAV)images captured under low-light conditions are often suffering from noise and uneven illumination.To address these issues,we propose a low-light image enhancement algorithm for UAV imag...The unmanned aerial vehicle(UAV)images captured under low-light conditions are often suffering from noise and uneven illumination.To address these issues,we propose a low-light image enhancement algorithm for UAV images,which is inspired by the Retinex theory and guided by a light weighted map.Firstly,we propose a new network for reflectance component processing to suppress the noise in images.Secondly,we construct an illumination enhancement module that uses a light weighted map to guide the enhancement process.Finally,the processed reflectance and illumination components are recombined to obtain the enhancement results.Experimental results show that our method can suppress the noise in images while enhancing image brightness,and prevent over enhancement in bright regions.Code and data are available at https://gitee.com/baixiaotong2/uav-images.git.展开更多
Hydrogen partitioning between liquid iron alloys and silicate melts governs its distribution and cycling in Earth’s deep interior.Existing models based on simplified Fe-H systems predict strong hydrogen sequestration...Hydrogen partitioning between liquid iron alloys and silicate melts governs its distribution and cycling in Earth’s deep interior.Existing models based on simplified Fe-H systems predict strong hydrogen sequestration into the core.However,these models do not account for the modulating effects of major light elements such as oxygen and silicon in the core during Earth’s primordial differentiation.In this study,we use first-principles molecular dynamics simulations,augmented by machine learning techniques,to quantify hydrogen chemical potentials in quaternary Fe-O-Si-H systems under early core-mantle boundary conditions(135 GPa,5000 K).Our results demonstrate that the presence of 5.2 wt%oxygen and 4.8 wt%silicon reduces the siderophile affinity of hydrogen by 35%,decreasing its alloy-silicate partition coefficient from 18.2(in the case of Fe-H)to 11.8(in the case of Fe-O-Si-H).These findings suggest that previous estimates of the core hydrogen content derived from binary system models require downward revision.Our study underscores the critical role of multicomponent interactions in core formation models and provides first-principles-derived constraints to reconcile Earth’s present-day hydrogen reservoirs with its accretionary history.展开更多
The removal of ammonia nitrogen(NH_(4)^(+)-N)and bacteria from aquaculture wastewater holds paramount ecological and production significance.In this study,Pt/RuO_(2)/g-C_(3)N_(4)photocatalysts were prepared by deposit...The removal of ammonia nitrogen(NH_(4)^(+)-N)and bacteria from aquaculture wastewater holds paramount ecological and production significance.In this study,Pt/RuO_(2)/g-C_(3)N_(4)photocatalysts were prepared by depositing Pt and RuO_(2)particles onto g-C_(3)N_(4).The physicochemical properties of photocatalysts were explored by X-ray photoelectron spectroscopy(XPS),scanning electron microscopy(SEM),X-ray diffraction(XRD),and UV–vis diffuse reflectance spectrometer(UV–vis DRS).The photocatalysts were then applied to the removal of both NH_(4)^(+)-N and bacteria from simulated mariculture wastewater.The results clarified that the removals of both NH_(4)^(+)-N and bacteria were in the sequence of g-C_(3)N_(4)<RuO_(2)/g-C_(3)N_(4)<Pt/g-C_(3)N_(4)<Pt/RuO_(2)/g-C_(3)N_(4).This magnificent photocatalytic ability of Pt/RuO_(2)/g-C_(3)N_(4)can be interpreted by the transfer of holes from g-C_(3)N_(4)to RuO_(2)to facilitate the in situ generation of HClO from Cl^(−)in wastewater,while Pt extracts photogenerated electrons for H_(2)formation to enhance the reaction.The removal of NH_(4)^(+)-N and disinfection effect were more pronounced in simulated seawater than in purewater.The removal efficiency ofNH_(4)^(+)-N increases with an increase in pH of wastewater,while the bactericidal effect was more significant under a lower pH in a pH range of 6–9.In actual seawater aquaculture wastewater,Pt/RuO_(2)/g-C_(3)N_(4)still exhibits effective removal efficiency of NH_(4)^(+)-N and bactericidal performance under sunlight.This study provides an alternative avenue for removement of NH_(4)^(+)-N and bacteria from saline waters under sunlight.展开更多
文摘1《The Unbearable Lightness of Being》简介
《The Unbearable Lightness of Being》是捷克作家米兰·昆德拉的作品，发表于1984年。其被我国读者所了解应在1987年韩少功和韩刚合译该书之后。自此，专家学者们对小说又有了一系列的重译和解读。本文讨论所使用的是Michael Henry Heim所翻译的英文电子版.
文摘A perceptual lightness anchoring model based on visual cognition is proposed. It can recover absolute lightness of natural images using filling-in mechanism from single-scale boundaries. First, it adapts the response of retinal photoreceptors to varying levels of illumination. Then luminance-correlated contrast information can be obtained through multiplex encoding without additional luminance channel. Dynamic normalization is used to get smooth and continuous boundary contours. Different boundaries are used for ON and OFF channel diffusion layers. Theoretical analysis and simulation results indicate that the model could recover natural images under varying illumination, and solve the trapping, blurring and fogging problems to some extent.
文摘This paper proposed a new algorithm to separate leukocytes from cytological image by setting parameters of lightness transformation based on the RGB color space, which can make the targets’ color in different areas. In our procedure, an operator is employed in using color features. According to their histogram distribution of hue component in HSL color space after enhancing the contrast of image in RGB color space, the threshold of segmentation between leukocyte and erythrocyte could be achieved well. Especially, this algorithm is more efficient than monochrome for leukocyte segmentation, and the results of experiments show that it provides a good tool for cytological image, which can increase accuracy of segmentation of leukocyte.
基金supported by the Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences(CI2021A04013)the National Natural Science Foundation of China(82204610)+1 种基金the Qihang Talent Program(L2022046)the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-041 and L2021029).
文摘Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.
基金supported by National Natural Science Foundation of China(32494793).
文摘Cellulose frameworks have emerged as promising materials for light management due to their exceptional light-scattering capabilities and sustainable nature.Conventional biomass-derived cellulose frameworks face a fundamental trade-off between haze and transparency,coupled with impractical thicknesses(≥1 mm).Inspired by squid’s skin-peeling mechanism,this work develops a peroxyformic acid(HCOOOH)-enabled precision peeling strategy to isolate intact 10-μm-thick bamboo green(BG)frameworks—100×thinner than wood-based counterparts while achieving an unprecedented optical performance(88%haze with 80%transparency).This performance surpasses delignified biomass(transparency<40%at 1 mm)and matches engineered cellulose composites,yet requires no energy-intensive nanofibrillation.The preserved native cellulose I crystalline structure(64.76%crystallinity)and wax-coated uniaxial fibril alignment(Hermans factor:0.23)contribute to high mechanical strength(903 MPa modulus)and broadband light scattering.As a light-management layer in polycrystalline silicon solar cells,the BG framework boosts photoelectric conversion efficiency by 0.41%absolute(18.74%→19.15%),outperforming synthetic anti-reflective coatings.The work establishes a scalable,waste-to-wealth route for optical-grade cellulose materials in next-generation optoelectronics.
文摘Mise en abyme, according to Gregory Minissale's definition, is "a process of representation within representation". It is a narrative technique characterised by eternal extension of repetitive images. Under Paul Ricoeur's framework of narrative-metaphor analogy, mise en abyme can be regarded not as a blank intertextuality, but as an allegorical infinity structurally performed by textual arrangement. Following his discussion, it is important to explore the functions of allegory from the connection of text and reality to the integration of different elements of text, such as plots, rhetoric usage, ideas, personal characters, etc. As both narrative and the reality imitated by narrative are bound with time, the temporality of mise en abyme enables narrative to be more internally referable. This referability is significant to understand how narrative constitutes reader reception. Structured with this central idea, this paper examines Nietzsche's "eternal recurrence" mentioned in Milan Kundera's novel The Unbearable Lightness of Being and the Sisyphusian life mode in the enclosed communist countryside shown in Ah Cheng's novella "The King of Children".
基金supported by the National Natural Science Foundation of China,Nos.82171076(to XS)and U22A20311(to XS),82101168(to TL)Shanghai Science and technology Innovation Action Plan,No.23Y11901300(to JS)+1 种基金Science and Technology Commission of Shanghai Municipality,No.21ZR1451500(to TL)Shanghai Pujiang Program,No.22PJ1412200(to BY)。
文摘Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss.Ferroptosis has been demonstrated to be associated with retinal degenerative diseases.However,the molecular mechanisms underlying ferroptosis and photoreceptor cell death in age-related macular degeneration remain largely unexplored.Bioinformatics and biochemical analyses in this study revealed xC^(–),solute carrier family 7 member 11-regulated ferroptosis as the predominant pathological process of photoreceptor cell degeneration in a light-induced dry age-related macular degeneration mouse model.This process involves the nuclear factor-erythroid factor 2-related factor 2-solute carrier family 7 member 11-glutathione peroxidase 4 signaling pathway,through which cystine depletion,iron ion accumulation,and enhanced lipid peroxidation ultimately lead to photoreceptor cell death and subsequent visual function impairment.We demonstrated that solute carrier family 7 member 11 overexpression blocked this process by inhibiting oxidative stress in vitro and in vivo.Conversely,solute carrier family 7 member 11 knockdown or the solute carrier family 7 member 11 inhibitor sulfasalazine and ferroptosis-inducing agent erastin aggravated H_(2)O_(2)-induced ferroptosis of 661W cells.These findings indicate solute carrier family 7 member 11 may be a potential therapeutic target for patients with retinal degenerative diseases including age-related macular degeneration.
文摘Biti’s is one of the largest footwear manufacturers in Vietnam.Made from homegrown high-quality natural rubber,Biti’s slippers are known for their slip-resistance,durability,lightness,and breathability.In addition to practicality and comfort,the products come in diverse styles at affordable prices.
基金supported by Yuan Du Scholars,Clinical Research Center of Affiliated Hospital of Shandong Second Medical University,No.2022WYFYLCYJ02Weifang Key Laboratory,Weifang Science and Technology Development Plan Project Medical Category,No.2022YX093.
文摘The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically reviewed.Here,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion injury.We further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple mechanisms.Inhibition of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.
文摘Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely limited.The principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial cells.The biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even urine.Among these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and muscles.Neurofilament light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and sensitivity.However,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal injury.Glial fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration rate.TAR DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related research.Evidence is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease prognosis.Despite the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable challenge.This review summarizes the latest research achievements concerning blood biomarkers in amyotrophic lateral sclerosis that can provide a more direct basis for the differential diagnosis and prognostic assessment of the disease beyond a reliance on clinical manifestations and electromyography findings.
基金supported by National Natural Science Foundation of China(12374358,91950207)Guangdong Basic and Applied Basic Research Foundation(2024A1515010420).
文摘Glucose molecules are of great significance being one of the most important molecules in metabolic chain.However,due to the small Raman scattering cross-section and weak/non-adsorption on bare metals,accurately obtaining their"fingerprint information"remains a huge obstacle.Herein,we developed a tip-enhanced Raman scattering(TERS)technique to address this challenge.Adopting an optical fiber radial vector mode internally illuminates the plasmonic fiber tip to effectively suppress the background noise while generating a strong electric-field enhanced tip hotspot.Furthermore,the tip hotspot approaching the glucose molecules was manipulated via the shear-force feedback to provide more freedom for selecting substrates.Consequently,our TERS technique achieves the visualization of all Raman modes of glucose molecules within spectral window of 400-3200 cm^(-1),which is not achievable through the far-field/surface-enhanced Raman,or the existing TERS techniques.Our TERS technique offers a powerful tool for accurately identifying Raman scattering of molecules,paving the way for biomolecular analysis.
基金supported by the Key Research and Development Program in Shaanxi Province,China(No.2022ZDLSF07-05)the Fundamental Research Funds for the Central Universities,CHD(No.300102352901)。
文摘Carbon emissions resulting from energy consumption have become a pressing issue for governments worldwide.Accurate estimation of carbon emissions using satellite remote sensing data has become a crucial research problem.Previous studies relied on statistical regression models that failed to capture the complex nonlinear relationships between carbon emissions and characteristic variables.In this study,we propose a machine learning algorithm for carbon emissions,a Bayesian optimized XGboost regression model,using multi-year energy carbon emission data and nighttime lights(NTL)remote sensing data from Shaanxi Province,China.Our results demonstrate that the XGboost algorithm outperforms linear regression and four other machine learning models,with an R^(2)of 0.906 and RMSE of 5.687.We observe an annual increase in carbon emissions,with high-emission counties primarily concentrated in northern and central Shaanxi Province,displaying a shift from discrete,sporadic points to contiguous,extended spatial distribution.Spatial autocorrelation clustering reveals predominantly high-high and low-low clustering patterns,with economically developed counties showing high-emission clustering and economically relatively backward counties displaying low-emission clustering.Our findings show that the use of NTL data and the XGboost algorithm can estimate and predict carbon emissionsmore accurately and provide a complementary reference for satellite remote sensing image data to serve carbon emission monitoring and assessment.This research provides an important theoretical basis for formulating practical carbon emission reduction policies and contributes to the development of techniques for accurate carbon emission estimation using remote sensing data.
基金supported by the National Natural Science Foundation of China(Nos.62201454 and 62306235)the Xi’an Science and Technology Program of Xi’an Science and Technology Bureau(No.23SFSF0004)。
文摘The unmanned aerial vehicle(UAV)images captured under low-light conditions are often suffering from noise and uneven illumination.To address these issues,we propose a low-light image enhancement algorithm for UAV images,which is inspired by the Retinex theory and guided by a light weighted map.Firstly,we propose a new network for reflectance component processing to suppress the noise in images.Secondly,we construct an illumination enhancement module that uses a light weighted map to guide the enhancement process.Finally,the processed reflectance and illumination components are recombined to obtain the enhancement results.Experimental results show that our method can suppress the noise in images while enhancing image brightness,and prevent over enhancement in bright regions.Code and data are available at https://gitee.com/baixiaotong2/uav-images.git.
基金supported by the National Key R&D Program of China(Grant No.2022YFF0503203)National Natural Science Foundation of China(NSFC)projects(Grant Nos.42441826 and 42173041)+1 种基金the Key Research Program of the Institute of Geology and Geophysics,Chinese Academy of Sciences(Grant No.IGGCAS-202204)the computational facilities of the Computer Simulation Laboratory at IGGCAS and the Beijing Super Cloud Computing Center(BSCC).
文摘Hydrogen partitioning between liquid iron alloys and silicate melts governs its distribution and cycling in Earth’s deep interior.Existing models based on simplified Fe-H systems predict strong hydrogen sequestration into the core.However,these models do not account for the modulating effects of major light elements such as oxygen and silicon in the core during Earth’s primordial differentiation.In this study,we use first-principles molecular dynamics simulations,augmented by machine learning techniques,to quantify hydrogen chemical potentials in quaternary Fe-O-Si-H systems under early core-mantle boundary conditions(135 GPa,5000 K).Our results demonstrate that the presence of 5.2 wt%oxygen and 4.8 wt%silicon reduces the siderophile affinity of hydrogen by 35%,decreasing its alloy-silicate partition coefficient from 18.2(in the case of Fe-H)to 11.8(in the case of Fe-O-Si-H).These findings suggest that previous estimates of the core hydrogen content derived from binary system models require downward revision.Our study underscores the critical role of multicomponent interactions in core formation models and provides first-principles-derived constraints to reconcile Earth’s present-day hydrogen reservoirs with its accretionary history.
基金supported by the Science and Technology Planning Project of Fujian Province(No.2023Y4015)the Marine and Fishery Development Special Fund of Xiamen(No.23YYST064QCB36)the Natural Science Foundation of Fujian Province(No.2021J011210).
文摘The removal of ammonia nitrogen(NH_(4)^(+)-N)and bacteria from aquaculture wastewater holds paramount ecological and production significance.In this study,Pt/RuO_(2)/g-C_(3)N_(4)photocatalysts were prepared by depositing Pt and RuO_(2)particles onto g-C_(3)N_(4).The physicochemical properties of photocatalysts were explored by X-ray photoelectron spectroscopy(XPS),scanning electron microscopy(SEM),X-ray diffraction(XRD),and UV–vis diffuse reflectance spectrometer(UV–vis DRS).The photocatalysts were then applied to the removal of both NH_(4)^(+)-N and bacteria from simulated mariculture wastewater.The results clarified that the removals of both NH_(4)^(+)-N and bacteria were in the sequence of g-C_(3)N_(4)<RuO_(2)/g-C_(3)N_(4)<Pt/g-C_(3)N_(4)<Pt/RuO_(2)/g-C_(3)N_(4).This magnificent photocatalytic ability of Pt/RuO_(2)/g-C_(3)N_(4)can be interpreted by the transfer of holes from g-C_(3)N_(4)to RuO_(2)to facilitate the in situ generation of HClO from Cl^(−)in wastewater,while Pt extracts photogenerated electrons for H_(2)formation to enhance the reaction.The removal of NH_(4)^(+)-N and disinfection effect were more pronounced in simulated seawater than in purewater.The removal efficiency ofNH_(4)^(+)-N increases with an increase in pH of wastewater,while the bactericidal effect was more significant under a lower pH in a pH range of 6–9.In actual seawater aquaculture wastewater,Pt/RuO_(2)/g-C_(3)N_(4)still exhibits effective removal efficiency of NH_(4)^(+)-N and bactericidal performance under sunlight.This study provides an alternative avenue for removement of NH_(4)^(+)-N and bacteria from saline waters under sunlight.
