Background Disturbed circadian rhythm is a potential cause of delirium and is linked to disorganisation of the circadian rhythmicity. Dynamic light （DL） could reset the circadian rhythm by activation of the suprachi...Background Disturbed circadian rhythm is a potential cause of delirium and is linked to disorganisation of the circadian rhythmicity. Dynamic light （DL） could reset the circadian rhythm by activation of the suprachiasmatic nucleus to prevent delirium. Evidence regarding the effects of light therapy is predominantly focused on psychiatric disorders and circadian rhythm sleep disorders. In this study, we investi- gated the effect of DL on the total hospital length of stay （LOS） and occurrence of delirium in patients admitted to the Coronary Care Unit （CCU）. Methods This was a retrospective cohort study. Patients older than 18 years, who were hospitalized longer than 12 h at the CCU and had a total hospital LOS for at least 24 h, were included. Patients were assigned to a room with DL （n = 369） or regular lighting condi- tions （n = 379）. DL was administered at the CCU by two ceiling-mounted light panels delivering light with a colour temperature between 2700 and 6500 degrees Kelvin. Reported outcome data were： total hospital LOS, delirium incidence, consultation of a geriatrician and the amount of prescripted antipsychotics. Results Between May 2015 and May 2016, data from 748 patients were collected. Baseline charac- teristics, including risk factors provoking delirium, were equal in both groups. Median total hospital LOS in the DL group was 100.5 （70.8-186.0） and 101.0 （73.0-176.4） h in the control group （P = 0.935）. The incidence of delirium in the DL and control group was 5.4% （20/369） and 5.0% （19/379）, respectively （P = 0.802）. No significant differences between the DL and control group were observed in secon- dary endpoints. Subgroup analysis based on age and CCU LOS also showed no differences. Conclusion Our study suggests exposure to DL as an early single approach does not result in a reduction of total hospital LOS or reduced incidence of delirium. When delirium was diagnosed, it was associated with poor hospital outcome.展开更多
In this work,on-chip three-dimensional(3D)photonic integrated optical sources based on active fluorescent polymer waveguide microdisks are proposed for light display application.Fluorescent green and red oligomers wit...In this work,on-chip three-dimensional(3D)photonic integrated optical sources based on active fluorescent polymer waveguide microdisks are proposed for light display application.Fluorescent green and red oligomers with high-efficiency photoluminescence are doped into epoxy crosslinking SU-8 polymer as the waveguide gain medium.The microdisk-based on-chip optically pumping light sources are designed and fabricated using the organic functionalized materials by direct UV written process.The promising stacking dual-microdisk structures with double gain layers could provide white signal light source generated perpendicular to the chip,and green signal light source stimulated in the chip.The approach could realize the monolithically on-chip assembled vertical and horizontal bright emitters.The optical pumping threshold power is obtained as 50 mW with continuous-wave(CW)pumping.The average gain coefficient of a white light source is measured by vertical fiber coupling as 112 dB/W,and that of green light source by horizontal fiber coupling as 137 dB/W,respectively.The rising and falling response time of the on-chip optical sources are 60 and 80μs under modulating pulsed pumping.This technique is very promising for achieving 3D integrated light display application,including photonic circuits and optical information encryption.展开更多
1. An overall judgment on the situation 2006 saw the rapid growth of passenger vehicles, with the production capacity putting into use rose from less than 70 percent to around 80 percent. That with light commercial ve...1. An overall judgment on the situation 2006 saw the rapid growth of passenger vehicles, with the production capacity putting into use rose from less than 70 percent to around 80 percent. That with light commercial vehicles was similar too. The situation in 2005 and 2006 showed that there are no evidential overdone production capacity.展开更多
文摘Background Disturbed circadian rhythm is a potential cause of delirium and is linked to disorganisation of the circadian rhythmicity. Dynamic light （DL） could reset the circadian rhythm by activation of the suprachiasmatic nucleus to prevent delirium. Evidence regarding the effects of light therapy is predominantly focused on psychiatric disorders and circadian rhythm sleep disorders. In this study, we investi- gated the effect of DL on the total hospital length of stay （LOS） and occurrence of delirium in patients admitted to the Coronary Care Unit （CCU）. Methods This was a retrospective cohort study. Patients older than 18 years, who were hospitalized longer than 12 h at the CCU and had a total hospital LOS for at least 24 h, were included. Patients were assigned to a room with DL （n = 369） or regular lighting condi- tions （n = 379）. DL was administered at the CCU by two ceiling-mounted light panels delivering light with a colour temperature between 2700 and 6500 degrees Kelvin. Reported outcome data were： total hospital LOS, delirium incidence, consultation of a geriatrician and the amount of prescripted antipsychotics. Results Between May 2015 and May 2016, data from 748 patients were collected. Baseline charac- teristics, including risk factors provoking delirium, were equal in both groups. Median total hospital LOS in the DL group was 100.5 （70.8-186.0） and 101.0 （73.0-176.4） h in the control group （P = 0.935）. The incidence of delirium in the DL and control group was 5.4% （20/369） and 5.0% （19/379）, respectively （P = 0.802）. No significant differences between the DL and control group were observed in secon- dary endpoints. Subgroup analysis based on age and CCU LOS also showed no differences. Conclusion Our study suggests exposure to DL as an early single approach does not result in a reduction of total hospital LOS or reduced incidence of delirium. When delirium was diagnosed, it was associated with poor hospital outcome.
基金National Key Research and Development(R&D)Program of China(2019YFB2203001)National Natural Science Foundation of China(NSFC,No.62171195).
文摘In this work,on-chip three-dimensional(3D)photonic integrated optical sources based on active fluorescent polymer waveguide microdisks are proposed for light display application.Fluorescent green and red oligomers with high-efficiency photoluminescence are doped into epoxy crosslinking SU-8 polymer as the waveguide gain medium.The microdisk-based on-chip optically pumping light sources are designed and fabricated using the organic functionalized materials by direct UV written process.The promising stacking dual-microdisk structures with double gain layers could provide white signal light source generated perpendicular to the chip,and green signal light source stimulated in the chip.The approach could realize the monolithically on-chip assembled vertical and horizontal bright emitters.The optical pumping threshold power is obtained as 50 mW with continuous-wave(CW)pumping.The average gain coefficient of a white light source is measured by vertical fiber coupling as 112 dB/W,and that of green light source by horizontal fiber coupling as 137 dB/W,respectively.The rising and falling response time of the on-chip optical sources are 60 and 80μs under modulating pulsed pumping.This technique is very promising for achieving 3D integrated light display application,including photonic circuits and optical information encryption.
文摘1. An overall judgment on the situation 2006 saw the rapid growth of passenger vehicles, with the production capacity putting into use rose from less than 70 percent to around 80 percent. That with light commercial vehicles was similar too. The situation in 2005 and 2006 showed that there are no evidential overdone production capacity.
