An efficient method for the three-component azidopyridylation of unactivated alkenes to accessβ-pyridyl azides has been developed.The overall process involves a visible light-mediated radical-relay sequence that begi...An efficient method for the three-component azidopyridylation of unactivated alkenes to accessβ-pyridyl azides has been developed.The overall process involves a visible light-mediated radical-relay sequence that begins with an in situ generated methoxy radical,which may facilitate Si-N_(3) bond activation to generate azidyl radical under mild conditions.The ensuing azidyl radical adds to the alkenes to furnish the carbon-centered radicals which themselves add,in an intermolecular sense,to pyridinium salts.This three-component photocatalytic strategy is effective for a broad range of alkenes and N-heterocycles,and readily affords synthetically useful azidyl-and pyridyl-containing building blocks.This method provides new insights into methoxy radical-initiated relay reactions as well as access to a range of new molecular scaffolds.展开更多
基金Guangdong Basic and Applied Basic Research Foundation(Nos.2022A1515110367,and 2024A1515010884)the National Natural Science Foundation of China(No.22201104)the Science and Technology Projects in Guangzhou(No.2023A04J0079)for financial support.
文摘An efficient method for the three-component azidopyridylation of unactivated alkenes to accessβ-pyridyl azides has been developed.The overall process involves a visible light-mediated radical-relay sequence that begins with an in situ generated methoxy radical,which may facilitate Si-N_(3) bond activation to generate azidyl radical under mild conditions.The ensuing azidyl radical adds to the alkenes to furnish the carbon-centered radicals which themselves add,in an intermolecular sense,to pyridinium salts.This three-component photocatalytic strategy is effective for a broad range of alkenes and N-heterocycles,and readily affords synthetically useful azidyl-and pyridyl-containing building blocks.This method provides new insights into methoxy radical-initiated relay reactions as well as access to a range of new molecular scaffolds.
