The common marmoset （Callithrix jacchus） has attracted extensive attention for use as a non-human primate model in biomedical research, especially in the study of neuropsychiatric disorders. However, behavioral test...The common marmoset （Callithrix jacchus） has attracted extensive attention for use as a non-human primate model in biomedical research, especially in the study of neuropsychiatric disorders. However, behavioral test methods are still limited in the field of marmoset research. The light-dark box is widely used for the evaluation of anxiety in rodents, but little is known about light-dark preference in marmosets. Here, we modified the light-dark test to study this behavior. The modified apparatus consisted of three compartments： one transparent open area and two closed opaque compartments. The closed compartments could be dark or light. We found that both adult and young marmosets liked to explore the open area, but the young animals showed more interest than adults. Furthermore, when one of the closed compartments was light and the other dark, the adult marmosets showed a preference for the dark compartment, but the young animals had no preference. These results suggest that the exploratory behavior and the light-dark preference in marmosets are age-dependent. Our study provides a new method to study exploration, anxiety, and fear in marmosets.展开更多
In the proposed light-dark dual universe, the light universe is the observable universe with light and kinetic energy that fueled the Big Bang, and the dark universe without light and kinetic energy has been observed ...In the proposed light-dark dual universe, the light universe is the observable universe with light and kinetic energy that fueled the Big Bang, and the dark universe without light and kinetic energy has been observed as dark energy since about 9 billion years after the Big Bang. The light-dark dual universe started from the zero-energy universe through the four-stage cyclic transformation. Emerging from the zero-energy universe, the four-stage transformation consists of the 11D (dimensional) positive-negative energy dual membrane universe, the 10D positive-negative energy dual string universe, the 10D positive-negative energy dual particle universe, and the 4D (light)-variable D (dark) positive-negative energy dual particle asymmetrical universe. The transformation can then be reversed back to the zero-energy universe through the reverse four-stage transformation. The light universe is an observable four-dimensional universe started with the inflation and the Big Bang, and the dark universe is a variable dimensional universe from 10D to 4D. The dark universe could be observed as dark energy only when the dark universe turned into a four-dimensional universe. The four-stage transformation explains the four force fields in our universe. The theoretical calculated percentages of dark energy, dark matter, and baryonic matter are 72.8. 22.7, and 4.53, respectively, in nearly complete agreement with observed 72.8, 22.7, and 4.56, respectively. According to the calculation, dark energy started in 4.47 billion years ago in agreement with the observed 4.71 ± 0.98 billion years ago. The zero-energy cyclic universe is based on the space-object structures.展开更多
基金supported by the Youth Innovation Promotion Association of the Chinese Academy of Sciences and an SA-SIBS scholarshipthe National Basic Research Development Program (973 Program) of China (2011CBA00400)the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020100)
文摘The common marmoset （Callithrix jacchus） has attracted extensive attention for use as a non-human primate model in biomedical research, especially in the study of neuropsychiatric disorders. However, behavioral test methods are still limited in the field of marmoset research. The light-dark box is widely used for the evaluation of anxiety in rodents, but little is known about light-dark preference in marmosets. Here, we modified the light-dark test to study this behavior. The modified apparatus consisted of three compartments： one transparent open area and two closed opaque compartments. The closed compartments could be dark or light. We found that both adult and young marmosets liked to explore the open area, but the young animals showed more interest than adults. Furthermore, when one of the closed compartments was light and the other dark, the adult marmosets showed a preference for the dark compartment, but the young animals had no preference. These results suggest that the exploratory behavior and the light-dark preference in marmosets are age-dependent. Our study provides a new method to study exploration, anxiety, and fear in marmosets.
文摘In the proposed light-dark dual universe, the light universe is the observable universe with light and kinetic energy that fueled the Big Bang, and the dark universe without light and kinetic energy has been observed as dark energy since about 9 billion years after the Big Bang. The light-dark dual universe started from the zero-energy universe through the four-stage cyclic transformation. Emerging from the zero-energy universe, the four-stage transformation consists of the 11D (dimensional) positive-negative energy dual membrane universe, the 10D positive-negative energy dual string universe, the 10D positive-negative energy dual particle universe, and the 4D (light)-variable D (dark) positive-negative energy dual particle asymmetrical universe. The transformation can then be reversed back to the zero-energy universe through the reverse four-stage transformation. The light universe is an observable four-dimensional universe started with the inflation and the Big Bang, and the dark universe is a variable dimensional universe from 10D to 4D. The dark universe could be observed as dark energy only when the dark universe turned into a four-dimensional universe. The four-stage transformation explains the four force fields in our universe. The theoretical calculated percentages of dark energy, dark matter, and baryonic matter are 72.8. 22.7, and 4.53, respectively, in nearly complete agreement with observed 72.8, 22.7, and 4.56, respectively. According to the calculation, dark energy started in 4.47 billion years ago in agreement with the observed 4.71 ± 0.98 billion years ago. The zero-energy cyclic universe is based on the space-object structures.
