Traffic intersections are incredibly dangerous for drivers and pedestrians. Statistics from both Canada and the U.S. show a high number of fatalities and serious injuries related to crashes at intersections. In Canada...Traffic intersections are incredibly dangerous for drivers and pedestrians. Statistics from both Canada and the U.S. show a high number of fatalities and serious injuries related to crashes at intersections. In Canada, during 2019, the National Collision Database shows that 28% of traffic fatalities and 42% of serious injuries occurred at intersections. Likewise, the U.S. National Highway Traffic Administration (NHTSA) found that about 40% of the estimated 5,811,000 accidents in the U.S. during the year studied were intersection-related crashes. In fact, a major survey by the car insurance industry found that nearly 85% of drivers could not identify the correct action to take when approaching a yellow traffic light at an intersection. One major reason for these accidents is the “yellow light dilemma,” the ambiguous situation where a driver should stop or proceed forward when unexpectedly faced with a yellow light. This situation is even further exacerbated by the tendency of aggressive drivers to inappropriately speed up on the yellow just to get through the traffic light. A survey of Canadian drivers conducted by the Traffic Injury Research Foundation found that 9% of drivers admitted to speeding up to get through a traffic light. Another reason for these accidents is the increased danger of making a left-hand turn on yellow. According to the National Highway Traffic Safety Association (NHTSA), left turns occur in approximately 22.2% of collisions—as opposed to just 1.2% for right turns. Moreover, a study by CNN found left turns are three times as likely to kill pedestrians than right turns. The reason left turns are so much more likely to cause an accident is because they take a driver against traffic and in the path of oncoming cars. Additionally, most of these left turns occur at the driver’s discretion—as opposed to the distressingly brief left-hand arrow at busy intersections. Drive Safe Now proposes a workable solution for reducing the number of accidents occurring during a yellow light at intersections. We believe this fairly simple solution will save lives, prevent injuries, reduce damage to public and private property, and decrease insurance costs.展开更多
This paper formulates the light timing calculations for each interferometer arm;one that is parallel to the direction of motion of the interferometer through space and the other that is perpendicular. The calculations...This paper formulates the light timing calculations for each interferometer arm;one that is parallel to the direction of motion of the interferometer through space and the other that is perpendicular. The calculations are done for a vacuum-mode interferometer and then for a gas-mode interferometer. The calculations show that no light timing difference is detectable in a vacuum-mode interferometer, but once an optical medium is present in the light path down the arms of the interferometer, this is no longer the case and a timing difference is detectable. Further to this, the timing equations obtained from the analysis are used to model the historical experiments of Michelson-Morley and Miller (Mt Wilson) and predictions are made by the model that accurately match the actual recorded results from those experiments. Thus, this timing analysis confirms that there is a light speed anisotropy in a reference frame that is moving through space, indicating the presence of a preferred Aether reference frame through which the Earth is moving.展开更多
Recently we have studied the instant-form quantization (IFQ) and the light-front quantization (LFQ) of the conformally gauge-fixed Polyakov D1 brane action using the Hamiltonian and path integral formulations. The IFQ...Recently we have studied the instant-form quantization (IFQ) and the light-front quantization (LFQ) of the conformally gauge-fixed Polyakov D1 brane action using the Hamiltonian and path integral formulations. The IFQ is studied in the equal world-sheet time framework on the hyperplanes defined by the world-sheet time σ0=τ=constant and the LFQ in the equal light-cone world-sheet time framework, on the hyperplanes of the light-front defined by the light-cone world-sheet time σ+= (τ+σ) =constant. The light-front theory is seen to be a constrained system in the sense of Dirac in contrast to the instant-form theory. However, owing to the gauge anomalous nature of these theories, both of these theories are seen to lack the usual string gauge symmetries defined by the world-sheet reparametrization invariance (WSRI) and the Weyl invariance (WI). In the present work we show that these theories when considered in the presence of background gauge fields such as the NSNS 2-form gauge field Bαβ(σ,τ) or in the presence of U(1) gauge field Aα(σ,τ) and the constant scalar axion field C(σ,τ), then they are seen to possess the usual string gauge symmetries (WSRI and WI). In fact, these background gauge fields are seen to behave as the Wess-Zumino or Stueckelberg fields and the terms containing these fields are seen to behave as Wess-Zumino or Stueckelberg terms for these theories.展开更多
BACKGROUND Pancreatic cancer is a highly invasive malignant tumor. Expression levels of the autophagy-related protein microtubule-associated protein 1 A/1 B-light chain 3(LC3) and perineural invasion(PNI) are closely ...BACKGROUND Pancreatic cancer is a highly invasive malignant tumor. Expression levels of the autophagy-related protein microtubule-associated protein 1 A/1 B-light chain 3(LC3) and perineural invasion(PNI) are closely related to its occurrence and development. Our previous results showed that the high expression of LC3 was positively correlated with PNI in the patients with pancreatic cancer. In this study, we further searched for differential genes involved in autophagy of pancreatic cancer by gene expression profiling and analyzed their biological functions in pancreatic cancer, which provides a theoretical basis for elucidating the pathophysiological mechanism of autophagy in pancreatic cancer and PNI.AIM To identify differentially expressed genes involved in pancreatic cancer autophagy and explore the pathogenesis at the molecular level.METHODS Two sets of gene expression profiles of pancreatic cancer/normal tissue(GSE16515 and GSE15471) were collected from the Gene Expression Omnibus.Significance analysis of microarrays algorithm was used to screen differentially expressed genes related to pancreatic cancer. Gene Ontology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis were used to analyze the functional enrichment of the differentially expressed genes. Protein interaction data containing only differentially expressed genes was downloaded from String database and screened. Module mining was carried out by Cytoscape software and ClusterOne plug-in. The interaction relationship between the modules was analyzed and the pivot nodes between the functional modules were determined according to the information of the functional modules and the data of reliable protein interaction network.RESULTS Based on the above two data sets of pancreatic tissue total gene expression, 6098 and 12928 differentially expressed genes were obtained by analysis of genes with higher phenotypic correlation. After extracting the intersection of the two differential gene sets, 4870 genes were determined. GO analysis showed that 14 significant functional items including negative regulation of protein ubiquitination were closely related to autophagy. A total of 986 differentially expressed genes were enriched in these functional items. After eliminating the autophagy related genes of human cancer cells which had been defined, 347 differentially expressed genes were obtained. KEGG pathway analysis showed that the pathways hsa04144 and hsa04020 were related to autophagy. In addition,65 clustering modules were screened after the protein interaction network was constructed based on String database, and module 32 contains the LC3 gene,which interacts with multiple autophagy-related genes. Moreover, ubiquitin C acts as a pivot node in functional modules to connect multiple modules related to pancreatic cancer and autophagy.CONCLUSION Three hundred and forty-seven genes associated with autophagy in human pancreatic cancer were concentrated, and a key gene ubiquitin C which is closely related to the occurrence of PNI was determined, suggesting that LC3 may influence the PNI and prognosis of pancreatic cancer through ubiquitin C.展开更多
Although multicrystalline Si photovoltaics have been extensively studied and applied in the collection of solar energy,the same systems suffer significant efficiency losses in indoor settings,where ambient light condi...Although multicrystalline Si photovoltaics have been extensively studied and applied in the collection of solar energy,the same systems suffer significant efficiency losses in indoor settings,where ambient light conditions are considerably smaller in intensity and possess greater components of non-normal incidence.Yet,indoor light-driven,stand-alone devices can offer sustainable advances in next-generation technologies such as the Internet of Things.Here,we present a non-invasive solution to aid in photovoltaic indoor light collection—radially distributed waveguide-encoded lattice(RDWEL)slim films(thickness 1.5 mm).Embedded with a monotonical radial array of cylindrical waveguides(±20°),the RDWEL demonstrates seamless light collection(FoV(fields of view)=74.5°)and imparts enhancements in JSC(short circuit current density)of 44%and 14%for indoor and outdoor lighting conditions,respectively,when coupled to a photovoltaic device and compared to an unstructured but otherwise identical slim film coating.展开更多
Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss.Ferroptosis has been demonstrated to be associated with retinal deg...Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss.Ferroptosis has been demonstrated to be associated with retinal degenerative diseases.However,the molecular mechanisms underlying ferroptosis and photoreceptor cell death in age-related macular degeneration remain largely unexplored.Bioinformatics and biochemical analyses in this study revealed xC^(–),solute carrier family 7 member 11-regulated ferroptosis as the predominant pathological process of photoreceptor cell degeneration in a light-induced dry age-related macular degeneration mouse model.This process involves the nuclear factor-erythroid factor 2-related factor 2-solute carrier family 7 member 11-glutathione peroxidase 4 signaling pathway,through which cystine depletion,iron ion accumulation,and enhanced lipid peroxidation ultimately lead to photoreceptor cell death and subsequent visual function impairment.We demonstrated that solute carrier family 7 member 11 overexpression blocked this process by inhibiting oxidative stress in vitro and in vivo.Conversely,solute carrier family 7 member 11 knockdown or the solute carrier family 7 member 11 inhibitor sulfasalazine and ferroptosis-inducing agent erastin aggravated H_(2)O_(2)-induced ferroptosis of 661W cells.These findings indicate solute carrier family 7 member 11 may be a potential therapeutic target for patients with retinal degenerative diseases including age-related macular degeneration.展开更多
To fully utilize the resources provided by optical fiber networks,a cross-band quantum light source generating photon pairs,where one photon in a pair is at C band and the other is at O band,is proposed in this work.T...To fully utilize the resources provided by optical fiber networks,a cross-band quantum light source generating photon pairs,where one photon in a pair is at C band and the other is at O band,is proposed in this work.This source is based on spontaneous four-wave mixing(SFWM)in a piece of shallow-ridge silicon waveguide.Theoretical analysis shows that the waveguide dispersion could be tailored by adjusting the ridge width,enabling broadband photon pair generation by SFWM across C band and O band.The spontaneous Raman scattering(SpRS)in silicon waveguides is also investigated experimentally.It shows that there are two regions in the spectrum of generated photons from SpRS,which could be used to achieve cross-band photon pair generation.A chip of shallow-ridge silicon waveguide samples with different ridge widths has been fabricated,through which cross-band photon pair generation is demonstrated experimentally.The experimental results show that the source can be achieved using dispersion-optimized shallow-ridge silicon waveguides.This cross-band quantum light source provides a way to develop new fiber-based quantum communication functions utilizing both C band and O band and extends applications of quantum networks.展开更多
The optical properties of N,N’-bis (Inaphthyl)N,N’-diphenyl-1,1’-biphenyl-4,4’-diamine (NPB) and tris (8-hydroxyquinolinato) aluminum (Alq3) organic materials used as hole transport and electron transport layers i...The optical properties of N,N’-bis (Inaphthyl)N,N’-diphenyl-1,1’-biphenyl-4,4’-diamine (NPB) and tris (8-hydroxyquinolinato) aluminum (Alq3) organic materials used as hole transport and electron transport layers in organic light-emitting devices (OLED) have been investigated. The NPB and Alq3 layers were prepared using thermal evaporation method. The results show that the energy band gap of Alq3 is thickness independence while the energy band gap of NPB decreases with the increasing of sample thickness. For the case of photoluminescence the Alq3 with thickness of 84 nm shows the highest relative intensity peak at 510 nm.展开更多
Aims: The paper explores the hypothesis that the speed of light c is decreasing over time at rate (dc/dt)=-H? c, H being the Hubble constant. This hypothesis differs from the so-called tired light, in which the veloci...Aims: The paper explores the hypothesis that the speed of light c is decreasing over time at rate (dc/dt)=-H? c, H being the Hubble constant. This hypothesis differs from the so-called tired light, in which the velocity c is supposed to vary during the journey of photons in the empty space for some frictional mechanism. In the hypothesis of the author the speed c, during this journey, is assumed constant. In this way the problems of the tired hypothesis are overcome. Methods: The paper links the variation dc/dt with the Hubble constant and infers a value of dc/dt from the difference between the value of the variation of the Earth-Moon distance measured by the Lunar Laser Ranging Experiment and the tidal effect. Results: Under the hypothesis c time varying, we explain: 1) The cosmological redshift. 2) The anomalous acceleration ap ≈ -8 × 10-10 m?sec-2, measured for some spacecrafts. 3) The high redshift of supernovae Ia, which seems to evidence an acceleration of the expansion of the universe. 4) The peripheral motion of stars in galaxies around their rotational centre. 5) The dilation of the light curves observed for supernovae Ia.展开更多
The process of disposing of expanded polystyrene (EPS) is by burning it in municipal incinerators. This process gives off EPS microplastics, which can find their way into water, food, blood, and major organ systems. Z...The process of disposing of expanded polystyrene (EPS) is by burning it in municipal incinerators. This process gives off EPS microplastics, which can find their way into water, food, blood, and major organ systems. Zophobas morio larvae are capable of consuming and breaking down EPS within their digestive tracts by minimizing the spread of microplastics. Studies of the consumption of EPS by Z. morio larvae are typically conducted under white or no visible light treatments. This study tested whether the color of visible light influenced the consumption rate of EPS by Z. morio larvae. If Z. morio larvae consume EPS under visible light, then visible light will influence the amount of EPS consumed. If results suggest that the consumption rate is influenced by visible light colors, then Z. morio larvae could be a solution for recycling EPS. This study’s procedure placed Z. morio larvae into 25 jars under one of six visible light treatments of red, yellow, green, blue, white, and no visible light. Each jar contained a pre-weighed block of EPS and six Z. morio larvae. After two weeks, the Z. morio larvae were removed from the jars, and the difference between each pre-weighed EPS block and the weight of the same partially consumed block was recorded in three trials. The data indicates that green and blue visible light treatments resulted in the greatest amount of EPS consumed by Z. morio larvae while the red and yellow had the least amount of EPS consumed by the Z. morio larvae. In conclusion, results indicate that green and blue visible light, compared to the no visible light treatment, could be used to influence the Z. morio larvae to consume more EPS. Green and blue visible light and Z. morio larvae could make the recycling process of EPS more environmentally friendly when used in households or by local environmental organizations.展开更多
In a recent paper we have studied the Hamiltonian and path integral quantizations of the conformally gauge-fixed Polyakov D1 brane action in the instant-form of dynamics using the equal world-sheet time framework on t...In a recent paper we have studied the Hamiltonian and path integral quantizations of the conformally gauge-fixed Polyakov D1 brane action in the instant-form of dynamics using the equal world-sheet time framework on the hyperplanes defined by the world- sheet time . In the present work we quantize the same theory in the equal light-cone world-sheet time framework, on the hyperplanes of the light-front defined by the light-cone world-sheet time , using the standard constraint quantization techniques in the Hamiltonian and path integral formulations. The light-front theory is seen to be a constrained system in the sense of Dirac, which is in contrast to the corresponding case of the instant-form theory, where the theory remains unconstrained in the sense of Dirac. The light-front theory is seen to possess a set of twenty six primary second-class contraints. In the present work Hamiltonian and path integral quantizations of this theory are studied on the light-front.展开更多
Quantum mechanics is a probabilistic theory of the universe suggestive of a mean value theory similar to thermodynamics prior to the introduction of the atomic theory. If QM will follow a similar path to thermodynamic...Quantum mechanics is a probabilistic theory of the universe suggestive of a mean value theory similar to thermodynamics prior to the introduction of the atomic theory. If QM will follow a similar path to thermodynamics, then a local deterministic theory must be developed which matches QM predictions. There have been four tough barriers to a local theory of light, of which Bell’s Theorem has been considered the ultimate barrier. The other three barriers are explaining spontaneous emission, the reflection of a small fraction of light at a dielectric interface and the splitting action of a polarizer on polarized light (Malus’ Law). The challenge is that in a local theory of light, everything must have a specific cause and effect. There can be nothing spontaneous or hidden. Local solutions to all four of these barriers are presented in this paper, integrating results from two previous papers and adding the solution paths to the third and fourth barriers as well, which are nearly identical. A previous paper [1] used results from Einstein’s famous 1917 paper on stimulated emission to provide a deterministic local model for spontaneous emission. A second paper [2] showed that QM predictions in tests of Bell’s theorem could be matched with a local model by modifying the definition of entanglement in a manner invisible to quantum mechanics. This paper summarizes and extends those two results and then presents a deterministic model of reflection from a dielectric interface and transmission of polarized light through a polarizer that both match quantum mechanics. As the framework of a local theory of light emerges, it is not surprising that we find corners of physics where small disagreements with quantum mechanics are predicted. A new Bell type test is described in this paper which can distinguish the local from the nonlocal theory, giving predictions that must disagree slightly but significantly with quantum mechanics. If such experiments are proven to disagree with quantum mechanics, then the door to a local theory of light will be opened.展开更多
Looped light in a recent sophisticated real three-slit experiment is interpreted as a strong justification of the old theoretical Peano-Hilbert spacetime model of Ord and El Naschie. This in turn entails the existence...Looped light in a recent sophisticated real three-slit experiment is interpreted as a strong justification of the old theoretical Peano-Hilbert spacetime model of Ord and El Naschie. This in turn entails the existence of extra fractal dimensions and consequently of real dark energy density in full agreement with previous analysis as well as accurate measurements and observations of COBE, WMAP, and the type 1a supernova.展开更多
The Chern-Simons theory in two-space one-time dimensions is quantized on the light-front under appropriate gauge-fixing conditions using the Hamiltonian, path integral and BRST formulations.
Background: Narrow band imaging (NBI) is reported to improve the diagnostic importance of nasopharyngeal cancer. The purpose of this review was to evaluate the diagnostic significance of NBI in the literature and comp...Background: Narrow band imaging (NBI) is reported to improve the diagnostic importance of nasopharyngeal cancer. The purpose of this review was to evaluate the diagnostic significance of NBI in the literature and compare it to the conventional white light endoscopy. The use of narrow band imaging (NBI) and further technological achievements concerning the resolution and magnification of endoscopic images have in the past 15 years. With the use of NBI, superficial mucosal lesions, which may be missed by standard WLI endoscopy, can be identified easily by their neoangiogenic pattern. Objective:?To assess diagnostic value of the narrow band imaging and white light endoscopy in nasopharyngeal carcinoma and compare diagnostic values (sensitivity, specificity, positive predictive value and negative predictive value) with white light endoscopy. Search Methods: From 2010 to 2020, data was searched from electronic databases such as PubMed, web of science. We used narrow band imaging as a key word accordance with diagnostic modalities such as sensitivity, specificity, PPV and NPV and data were collected. Results: We have found mainly 6 studies have discussed about diagnostic value of endoscopy in nasopharyngeal carcinoma in the total of 2746 suspected patients. Among them, 5 studies have compared diagnostic values such as sensitivity, specificity, positive predictive value and negative predictive value between NBI and WLE. Among 5 studies, 4 studies have found higher sensitivity in NBI, 2 studies found higher 1 equal to WLE specificity in NBI. 3 studies have compared PPV and NPV between NBI and WLE. Among them, all the studies found higher PPV and NPV in NBI than WLE. Conclusion: Recently?developed narrow band imaging has a great significance in the diagnosis of nasopharyngeal carcinoma. Although NBI has also encountered some problem such as contact bleeding and darker image. So, further evaluation should be done.展开更多
The wide-precision planting pattern has become widely used in the North China Plain as a practice for increasing wheat yield.However,the effects of tilled ng developme nt and light tran smissi on within can opy on whe...The wide-precision planting pattern has become widely used in the North China Plain as a practice for increasing wheat yield.However,the effects of tilled ng developme nt and light tran smissi on within can opy on wheat yield un der differe nt sowi ng widths have not bee n clearly described.Therefore,a two-year experime nt was con ducted,in cludi ng four different seeding widths(6 cm,W6;8 cm,W8;10 cm,W10;12 cm,W12)and the traditional planting pattern with seeding width of 4 cm(W4).The results indicated mainly positive effects by the reduced intraspecific competition,specifically all three yield components of W6 and W8 were higher than those for W4.The configurations with more than 10-cm seeding width were mainly affected by the negative effect of a relative homogeneous canopy,leading to the weakened light transmission,leaf senescence,and reduced grain number per spike.Finally,the yields of W6 and W8 were significantly higher than that of W4,whereas the yield in W12 was lower(though not significantly)than W4.In wheat production,therefore,the appropriate seeding width of 6-8 cm is recommended for farmers,whereas the too wide seeding width,with more than 10 cm,should be avoided.展开更多
Recently we have studied the instant-form quantization (IFQ) of the conformally gauge-fixed Polyakov D1 brane action with and without a scalar dilaton field using the Hamiltonian and path integral formulations in the ...Recently we have studied the instant-form quantization (IFQ) of the conformally gauge-fixed Polyakov D1 brane action with and without a scalar dilaton field using the Hamiltonian and path integral formulations in the equal world-sheet time framework on the hyperplanes defined by the world- sheet time σ0=τ=constant . The light-front quantization (LFQ) of this theory without a scalar dilaton field has also been studied by us recently. In the present work we study the LFQ of this theory in the equal light-cone world-sheet time framework, on the hyperplanes of the light-front defined by the light-cone world-sheet time σ+=τ+σ=constant , using the Hamiltonian and path integral formulations. The light-front theory is seen to be a constrained system in the sense of Dirac. The light-front theory is seen to possess a set of twenty seven primary second-class contraints. In the present work Hamiltonian and path integral quantizations of this theory are studied on the light-front.展开更多
This study developed a novel heterogeneous Vis-Photo+Fenton-like system by integrating visible-light-responsive Co_(3)O_(4)/TiO_(2) photocatalysis with peroxymonosulfate(PMS)activation for efficient atrazine(ATZ)degra...This study developed a novel heterogeneous Vis-Photo+Fenton-like system by integrating visible-light-responsive Co_(3)O_(4)/TiO_(2) photocatalysis with peroxymonosulfate(PMS)activation for efficient atrazine(ATZ)degradation.The synergistic process achieved complete ATZ removal within 60 min under near-neutral pH(6.9),outperform-ing individual Fenton-like(39%)and photocatalytic(24%)processes.Key factors influencing the degradation efficiency included light sources(UV>visible),pH(optimal at 6.9),catalyst dosage(0.01 g Co_(3)O_(4)/TiO_(2)),and PMS:ATZ molar ratio(1:2).The system exhibited a synergistic coefficient of 5.03(degradation)and 1.97(miner-alization),attributed to enhanced radical generation and accelerated Co^(3+)/Co^(2+)redox cycling through photoin-duced electron transfer.Intermediate analysis revealed dealkylation,dechlorination,and oxidation pathways,with reduced toxicity of by-products(e.g.,CEAT,CIAT)confirmed by ecotoxicity assessments.The mineralization efficiency(Vis-Photo+Fenton-like)reached 83.1%,significantly higher than that of standalone processes(Fenton-like:43.2%;photocatalysis:30.5%).The catalyst demonstrated excellent stability(nearly 90%recov-ery,<1μg/L Co leaching)and practical applicability.This study provides an efficient,sludge-free,and solar-compatible strategy for eliminating persistent herbicides in water treatment.展开更多
Background: Cyanobacteria phycocyanins (Cps) have already shown powerful antioxidant properties. In human cells submitted to oxidative stress the telomeres length decrease, the expression of progerin and the activity ...Background: Cyanobacteria phycocyanins (Cps) have already shown powerful antioxidant properties. In human cells submitted to oxidative stress the telomeres length decrease, the expression of progerin and the activity of mTOR are increased. At our knowledge, there is no published data on Cps correlated with ultraviolet radiation (UV) and blue light effects in human cells regarding telomeres’ length, progerin expression or mTOR1 complex activity. Objectives: In this study, we sought to assess 1) telomeres’ length in newborn human fibroblasts exposed to UV and blue light;2) progerin production in mature human normal fibroblasts exposed to UV;3) mTOR1 activation in adult human normal keratinocytes exposed to UV, analyzing the activity of a Cyanobacteria phycocyanin (Cp) in these in vitro models. Materials and Methods: Human skin fibroblasts or human normal keratinocytes were cultured—in the absence or in the presence of Cp and submitted to UVB + UVA and blue light irradiations. Telomeres’ length, progerin expression and mTOR1 activity were then assessed by molecular biology and immuno-enzymatic methods. Results: In cultured fibroblasts exposed to irradiations and treated by Cp, telomeres’ shortage and progerin expression were lower compared to irradiated untreated cells. In cultured keratinocytes treated by Cp and exposed to irradiations, the mTOR activity was lower compared to irradiated untreated cells. Conclusions: In these in vitro studies on human skin fibroblasts and on normal human keratinocytes, the cyanobacteria phycocyanin (Cp) showed a decrease of damages induced by UV and blue light expressed by telomeres preservation and downregulation of progerin expression and of mTOR activity, thus showing skin anti-aging and photo-protective potential.展开更多
文摘Traffic intersections are incredibly dangerous for drivers and pedestrians. Statistics from both Canada and the U.S. show a high number of fatalities and serious injuries related to crashes at intersections. In Canada, during 2019, the National Collision Database shows that 28% of traffic fatalities and 42% of serious injuries occurred at intersections. Likewise, the U.S. National Highway Traffic Administration (NHTSA) found that about 40% of the estimated 5,811,000 accidents in the U.S. during the year studied were intersection-related crashes. In fact, a major survey by the car insurance industry found that nearly 85% of drivers could not identify the correct action to take when approaching a yellow traffic light at an intersection. One major reason for these accidents is the “yellow light dilemma,” the ambiguous situation where a driver should stop or proceed forward when unexpectedly faced with a yellow light. This situation is even further exacerbated by the tendency of aggressive drivers to inappropriately speed up on the yellow just to get through the traffic light. A survey of Canadian drivers conducted by the Traffic Injury Research Foundation found that 9% of drivers admitted to speeding up to get through a traffic light. Another reason for these accidents is the increased danger of making a left-hand turn on yellow. According to the National Highway Traffic Safety Association (NHTSA), left turns occur in approximately 22.2% of collisions—as opposed to just 1.2% for right turns. Moreover, a study by CNN found left turns are three times as likely to kill pedestrians than right turns. The reason left turns are so much more likely to cause an accident is because they take a driver against traffic and in the path of oncoming cars. Additionally, most of these left turns occur at the driver’s discretion—as opposed to the distressingly brief left-hand arrow at busy intersections. Drive Safe Now proposes a workable solution for reducing the number of accidents occurring during a yellow light at intersections. We believe this fairly simple solution will save lives, prevent injuries, reduce damage to public and private property, and decrease insurance costs.
文摘This paper formulates the light timing calculations for each interferometer arm;one that is parallel to the direction of motion of the interferometer through space and the other that is perpendicular. The calculations are done for a vacuum-mode interferometer and then for a gas-mode interferometer. The calculations show that no light timing difference is detectable in a vacuum-mode interferometer, but once an optical medium is present in the light path down the arms of the interferometer, this is no longer the case and a timing difference is detectable. Further to this, the timing equations obtained from the analysis are used to model the historical experiments of Michelson-Morley and Miller (Mt Wilson) and predictions are made by the model that accurately match the actual recorded results from those experiments. Thus, this timing analysis confirms that there is a light speed anisotropy in a reference frame that is moving through space, indicating the presence of a preferred Aether reference frame through which the Earth is moving.
文摘Recently we have studied the instant-form quantization (IFQ) and the light-front quantization (LFQ) of the conformally gauge-fixed Polyakov D1 brane action using the Hamiltonian and path integral formulations. The IFQ is studied in the equal world-sheet time framework on the hyperplanes defined by the world-sheet time σ0=τ=constant and the LFQ in the equal light-cone world-sheet time framework, on the hyperplanes of the light-front defined by the light-cone world-sheet time σ+= (τ+σ) =constant. The light-front theory is seen to be a constrained system in the sense of Dirac in contrast to the instant-form theory. However, owing to the gauge anomalous nature of these theories, both of these theories are seen to lack the usual string gauge symmetries defined by the world-sheet reparametrization invariance (WSRI) and the Weyl invariance (WI). In the present work we show that these theories when considered in the presence of background gauge fields such as the NSNS 2-form gauge field Bαβ(σ,τ) or in the presence of U(1) gauge field Aα(σ,τ) and the constant scalar axion field C(σ,τ), then they are seen to possess the usual string gauge symmetries (WSRI and WI). In fact, these background gauge fields are seen to behave as the Wess-Zumino or Stueckelberg fields and the terms containing these fields are seen to behave as Wess-Zumino or Stueckelberg terms for these theories.
基金Supported by the National Natural Science Foundation of China,No.U1504815 and No.U1504808
文摘BACKGROUND Pancreatic cancer is a highly invasive malignant tumor. Expression levels of the autophagy-related protein microtubule-associated protein 1 A/1 B-light chain 3(LC3) and perineural invasion(PNI) are closely related to its occurrence and development. Our previous results showed that the high expression of LC3 was positively correlated with PNI in the patients with pancreatic cancer. In this study, we further searched for differential genes involved in autophagy of pancreatic cancer by gene expression profiling and analyzed their biological functions in pancreatic cancer, which provides a theoretical basis for elucidating the pathophysiological mechanism of autophagy in pancreatic cancer and PNI.AIM To identify differentially expressed genes involved in pancreatic cancer autophagy and explore the pathogenesis at the molecular level.METHODS Two sets of gene expression profiles of pancreatic cancer/normal tissue(GSE16515 and GSE15471) were collected from the Gene Expression Omnibus.Significance analysis of microarrays algorithm was used to screen differentially expressed genes related to pancreatic cancer. Gene Ontology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis were used to analyze the functional enrichment of the differentially expressed genes. Protein interaction data containing only differentially expressed genes was downloaded from String database and screened. Module mining was carried out by Cytoscape software and ClusterOne plug-in. The interaction relationship between the modules was analyzed and the pivot nodes between the functional modules were determined according to the information of the functional modules and the data of reliable protein interaction network.RESULTS Based on the above two data sets of pancreatic tissue total gene expression, 6098 and 12928 differentially expressed genes were obtained by analysis of genes with higher phenotypic correlation. After extracting the intersection of the two differential gene sets, 4870 genes were determined. GO analysis showed that 14 significant functional items including negative regulation of protein ubiquitination were closely related to autophagy. A total of 986 differentially expressed genes were enriched in these functional items. After eliminating the autophagy related genes of human cancer cells which had been defined, 347 differentially expressed genes were obtained. KEGG pathway analysis showed that the pathways hsa04144 and hsa04020 were related to autophagy. In addition,65 clustering modules were screened after the protein interaction network was constructed based on String database, and module 32 contains the LC3 gene,which interacts with multiple autophagy-related genes. Moreover, ubiquitin C acts as a pivot node in functional modules to connect multiple modules related to pancreatic cancer and autophagy.CONCLUSION Three hundred and forty-seven genes associated with autophagy in human pancreatic cancer were concentrated, and a key gene ubiquitin C which is closely related to the occurrence of PNI was determined, suggesting that LC3 may influence the PNI and prognosis of pancreatic cancer through ubiquitin C.
基金supported by the European Research Council(ERC)under the European Union's Horizon 2020 Research and Innovation Programme(Grant Agreement No.818762)the Engineering and Physical Sciences Research Council(Grant No.EP/V048953/1)and the Isaac Newton Trust(grant 22.39(m))。
文摘Although multicrystalline Si photovoltaics have been extensively studied and applied in the collection of solar energy,the same systems suffer significant efficiency losses in indoor settings,where ambient light conditions are considerably smaller in intensity and possess greater components of non-normal incidence.Yet,indoor light-driven,stand-alone devices can offer sustainable advances in next-generation technologies such as the Internet of Things.Here,we present a non-invasive solution to aid in photovoltaic indoor light collection—radially distributed waveguide-encoded lattice(RDWEL)slim films(thickness 1.5 mm).Embedded with a monotonical radial array of cylindrical waveguides(±20°),the RDWEL demonstrates seamless light collection(FoV(fields of view)=74.5°)and imparts enhancements in JSC(short circuit current density)of 44%and 14%for indoor and outdoor lighting conditions,respectively,when coupled to a photovoltaic device and compared to an unstructured but otherwise identical slim film coating.
基金supported by the National Natural Science Foundation of China,Nos.82171076(to XS)and U22A20311(to XS),82101168(to TL)Shanghai Science and technology Innovation Action Plan,No.23Y11901300(to JS)+1 种基金Science and Technology Commission of Shanghai Municipality,No.21ZR1451500(to TL)Shanghai Pujiang Program,No.22PJ1412200(to BY)。
文摘Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss.Ferroptosis has been demonstrated to be associated with retinal degenerative diseases.However,the molecular mechanisms underlying ferroptosis and photoreceptor cell death in age-related macular degeneration remain largely unexplored.Bioinformatics and biochemical analyses in this study revealed xC^(–),solute carrier family 7 member 11-regulated ferroptosis as the predominant pathological process of photoreceptor cell degeneration in a light-induced dry age-related macular degeneration mouse model.This process involves the nuclear factor-erythroid factor 2-related factor 2-solute carrier family 7 member 11-glutathione peroxidase 4 signaling pathway,through which cystine depletion,iron ion accumulation,and enhanced lipid peroxidation ultimately lead to photoreceptor cell death and subsequent visual function impairment.We demonstrated that solute carrier family 7 member 11 overexpression blocked this process by inhibiting oxidative stress in vitro and in vivo.Conversely,solute carrier family 7 member 11 knockdown or the solute carrier family 7 member 11 inhibitor sulfasalazine and ferroptosis-inducing agent erastin aggravated H_(2)O_(2)-induced ferroptosis of 661W cells.These findings indicate solute carrier family 7 member 11 may be a potential therapeutic target for patients with retinal degenerative diseases including age-related macular degeneration.
基金supported by the Quantum Science and Technology-National Science and Technology Major Project (Grant No.2024ZD0302502 for WZ)the National Natural Science Foundation of China(Grant No.92365210 for WZ)+1 种基金Tsinghua Initiative Scientific Research Program (for WZ)the project of Tsinghua University-Zhuhai Huafa Industrial Share Company Joint Institute for Architecture Optoelectronic Technologies (JIAOT,for YH)。
文摘To fully utilize the resources provided by optical fiber networks,a cross-band quantum light source generating photon pairs,where one photon in a pair is at C band and the other is at O band,is proposed in this work.This source is based on spontaneous four-wave mixing(SFWM)in a piece of shallow-ridge silicon waveguide.Theoretical analysis shows that the waveguide dispersion could be tailored by adjusting the ridge width,enabling broadband photon pair generation by SFWM across C band and O band.The spontaneous Raman scattering(SpRS)in silicon waveguides is also investigated experimentally.It shows that there are two regions in the spectrum of generated photons from SpRS,which could be used to achieve cross-band photon pair generation.A chip of shallow-ridge silicon waveguide samples with different ridge widths has been fabricated,through which cross-band photon pair generation is demonstrated experimentally.The experimental results show that the source can be achieved using dispersion-optimized shallow-ridge silicon waveguides.This cross-band quantum light source provides a way to develop new fiber-based quantum communication functions utilizing both C band and O band and extends applications of quantum networks.
文摘The optical properties of N,N’-bis (Inaphthyl)N,N’-diphenyl-1,1’-biphenyl-4,4’-diamine (NPB) and tris (8-hydroxyquinolinato) aluminum (Alq3) organic materials used as hole transport and electron transport layers in organic light-emitting devices (OLED) have been investigated. The NPB and Alq3 layers were prepared using thermal evaporation method. The results show that the energy band gap of Alq3 is thickness independence while the energy band gap of NPB decreases with the increasing of sample thickness. For the case of photoluminescence the Alq3 with thickness of 84 nm shows the highest relative intensity peak at 510 nm.
文摘Aims: The paper explores the hypothesis that the speed of light c is decreasing over time at rate (dc/dt)=-H? c, H being the Hubble constant. This hypothesis differs from the so-called tired light, in which the velocity c is supposed to vary during the journey of photons in the empty space for some frictional mechanism. In the hypothesis of the author the speed c, during this journey, is assumed constant. In this way the problems of the tired hypothesis are overcome. Methods: The paper links the variation dc/dt with the Hubble constant and infers a value of dc/dt from the difference between the value of the variation of the Earth-Moon distance measured by the Lunar Laser Ranging Experiment and the tidal effect. Results: Under the hypothesis c time varying, we explain: 1) The cosmological redshift. 2) The anomalous acceleration ap ≈ -8 × 10-10 m?sec-2, measured for some spacecrafts. 3) The high redshift of supernovae Ia, which seems to evidence an acceleration of the expansion of the universe. 4) The peripheral motion of stars in galaxies around their rotational centre. 5) The dilation of the light curves observed for supernovae Ia.
文摘The process of disposing of expanded polystyrene (EPS) is by burning it in municipal incinerators. This process gives off EPS microplastics, which can find their way into water, food, blood, and major organ systems. Zophobas morio larvae are capable of consuming and breaking down EPS within their digestive tracts by minimizing the spread of microplastics. Studies of the consumption of EPS by Z. morio larvae are typically conducted under white or no visible light treatments. This study tested whether the color of visible light influenced the consumption rate of EPS by Z. morio larvae. If Z. morio larvae consume EPS under visible light, then visible light will influence the amount of EPS consumed. If results suggest that the consumption rate is influenced by visible light colors, then Z. morio larvae could be a solution for recycling EPS. This study’s procedure placed Z. morio larvae into 25 jars under one of six visible light treatments of red, yellow, green, blue, white, and no visible light. Each jar contained a pre-weighed block of EPS and six Z. morio larvae. After two weeks, the Z. morio larvae were removed from the jars, and the difference between each pre-weighed EPS block and the weight of the same partially consumed block was recorded in three trials. The data indicates that green and blue visible light treatments resulted in the greatest amount of EPS consumed by Z. morio larvae while the red and yellow had the least amount of EPS consumed by the Z. morio larvae. In conclusion, results indicate that green and blue visible light, compared to the no visible light treatment, could be used to influence the Z. morio larvae to consume more EPS. Green and blue visible light and Z. morio larvae could make the recycling process of EPS more environmentally friendly when used in households or by local environmental organizations.
文摘In a recent paper we have studied the Hamiltonian and path integral quantizations of the conformally gauge-fixed Polyakov D1 brane action in the instant-form of dynamics using the equal world-sheet time framework on the hyperplanes defined by the world- sheet time . In the present work we quantize the same theory in the equal light-cone world-sheet time framework, on the hyperplanes of the light-front defined by the light-cone world-sheet time , using the standard constraint quantization techniques in the Hamiltonian and path integral formulations. The light-front theory is seen to be a constrained system in the sense of Dirac, which is in contrast to the corresponding case of the instant-form theory, where the theory remains unconstrained in the sense of Dirac. The light-front theory is seen to possess a set of twenty six primary second-class contraints. In the present work Hamiltonian and path integral quantizations of this theory are studied on the light-front.
文摘Quantum mechanics is a probabilistic theory of the universe suggestive of a mean value theory similar to thermodynamics prior to the introduction of the atomic theory. If QM will follow a similar path to thermodynamics, then a local deterministic theory must be developed which matches QM predictions. There have been four tough barriers to a local theory of light, of which Bell’s Theorem has been considered the ultimate barrier. The other three barriers are explaining spontaneous emission, the reflection of a small fraction of light at a dielectric interface and the splitting action of a polarizer on polarized light (Malus’ Law). The challenge is that in a local theory of light, everything must have a specific cause and effect. There can be nothing spontaneous or hidden. Local solutions to all four of these barriers are presented in this paper, integrating results from two previous papers and adding the solution paths to the third and fourth barriers as well, which are nearly identical. A previous paper [1] used results from Einstein’s famous 1917 paper on stimulated emission to provide a deterministic local model for spontaneous emission. A second paper [2] showed that QM predictions in tests of Bell’s theorem could be matched with a local model by modifying the definition of entanglement in a manner invisible to quantum mechanics. This paper summarizes and extends those two results and then presents a deterministic model of reflection from a dielectric interface and transmission of polarized light through a polarizer that both match quantum mechanics. As the framework of a local theory of light emerges, it is not surprising that we find corners of physics where small disagreements with quantum mechanics are predicted. A new Bell type test is described in this paper which can distinguish the local from the nonlocal theory, giving predictions that must disagree slightly but significantly with quantum mechanics. If such experiments are proven to disagree with quantum mechanics, then the door to a local theory of light will be opened.
文摘Looped light in a recent sophisticated real three-slit experiment is interpreted as a strong justification of the old theoretical Peano-Hilbert spacetime model of Ord and El Naschie. This in turn entails the existence of extra fractal dimensions and consequently of real dark energy density in full agreement with previous analysis as well as accurate measurements and observations of COBE, WMAP, and the type 1a supernova.
文摘The Chern-Simons theory in two-space one-time dimensions is quantized on the light-front under appropriate gauge-fixing conditions using the Hamiltonian, path integral and BRST formulations.
文摘Background: Narrow band imaging (NBI) is reported to improve the diagnostic importance of nasopharyngeal cancer. The purpose of this review was to evaluate the diagnostic significance of NBI in the literature and compare it to the conventional white light endoscopy. The use of narrow band imaging (NBI) and further technological achievements concerning the resolution and magnification of endoscopic images have in the past 15 years. With the use of NBI, superficial mucosal lesions, which may be missed by standard WLI endoscopy, can be identified easily by their neoangiogenic pattern. Objective:?To assess diagnostic value of the narrow band imaging and white light endoscopy in nasopharyngeal carcinoma and compare diagnostic values (sensitivity, specificity, positive predictive value and negative predictive value) with white light endoscopy. Search Methods: From 2010 to 2020, data was searched from electronic databases such as PubMed, web of science. We used narrow band imaging as a key word accordance with diagnostic modalities such as sensitivity, specificity, PPV and NPV and data were collected. Results: We have found mainly 6 studies have discussed about diagnostic value of endoscopy in nasopharyngeal carcinoma in the total of 2746 suspected patients. Among them, 5 studies have compared diagnostic values such as sensitivity, specificity, positive predictive value and negative predictive value between NBI and WLE. Among 5 studies, 4 studies have found higher sensitivity in NBI, 2 studies found higher 1 equal to WLE specificity in NBI. 3 studies have compared PPV and NPV between NBI and WLE. Among them, all the studies found higher PPV and NPV in NBI than WLE. Conclusion: Recently?developed narrow band imaging has a great significance in the diagnosis of nasopharyngeal carcinoma. Although NBI has also encountered some problem such as contact bleeding and darker image. So, further evaluation should be done.
基金This work was supported by the Special Fund for Agroscientific Research in the Public Interest,China(201503130).
文摘The wide-precision planting pattern has become widely used in the North China Plain as a practice for increasing wheat yield.However,the effects of tilled ng developme nt and light tran smissi on within can opy on wheat yield un der differe nt sowi ng widths have not bee n clearly described.Therefore,a two-year experime nt was con ducted,in cludi ng four different seeding widths(6 cm,W6;8 cm,W8;10 cm,W10;12 cm,W12)and the traditional planting pattern with seeding width of 4 cm(W4).The results indicated mainly positive effects by the reduced intraspecific competition,specifically all three yield components of W6 and W8 were higher than those for W4.The configurations with more than 10-cm seeding width were mainly affected by the negative effect of a relative homogeneous canopy,leading to the weakened light transmission,leaf senescence,and reduced grain number per spike.Finally,the yields of W6 and W8 were significantly higher than that of W4,whereas the yield in W12 was lower(though not significantly)than W4.In wheat production,therefore,the appropriate seeding width of 6-8 cm is recommended for farmers,whereas the too wide seeding width,with more than 10 cm,should be avoided.
文摘Recently we have studied the instant-form quantization (IFQ) of the conformally gauge-fixed Polyakov D1 brane action with and without a scalar dilaton field using the Hamiltonian and path integral formulations in the equal world-sheet time framework on the hyperplanes defined by the world- sheet time σ0=τ=constant . The light-front quantization (LFQ) of this theory without a scalar dilaton field has also been studied by us recently. In the present work we study the LFQ of this theory in the equal light-cone world-sheet time framework, on the hyperplanes of the light-front defined by the light-cone world-sheet time σ+=τ+σ=constant , using the Hamiltonian and path integral formulations. The light-front theory is seen to be a constrained system in the sense of Dirac. The light-front theory is seen to possess a set of twenty seven primary second-class contraints. In the present work Hamiltonian and path integral quantizations of this theory are studied on the light-front.
基金supported by the Financial Supports of the National Natural Science Foundation of China(Nos.51508056,52370030 and 42007352)the Chongqing Postgraduate Joint Training Base Project(No.JDLHPYJD2022005)the special fund of Henan Key Labora-tory of Water Pollution Control and Rehabilitation Technology(No.CJSZ2024001).
文摘This study developed a novel heterogeneous Vis-Photo+Fenton-like system by integrating visible-light-responsive Co_(3)O_(4)/TiO_(2) photocatalysis with peroxymonosulfate(PMS)activation for efficient atrazine(ATZ)degradation.The synergistic process achieved complete ATZ removal within 60 min under near-neutral pH(6.9),outperform-ing individual Fenton-like(39%)and photocatalytic(24%)processes.Key factors influencing the degradation efficiency included light sources(UV>visible),pH(optimal at 6.9),catalyst dosage(0.01 g Co_(3)O_(4)/TiO_(2)),and PMS:ATZ molar ratio(1:2).The system exhibited a synergistic coefficient of 5.03(degradation)and 1.97(miner-alization),attributed to enhanced radical generation and accelerated Co^(3+)/Co^(2+)redox cycling through photoin-duced electron transfer.Intermediate analysis revealed dealkylation,dechlorination,and oxidation pathways,with reduced toxicity of by-products(e.g.,CEAT,CIAT)confirmed by ecotoxicity assessments.The mineralization efficiency(Vis-Photo+Fenton-like)reached 83.1%,significantly higher than that of standalone processes(Fenton-like:43.2%;photocatalysis:30.5%).The catalyst demonstrated excellent stability(nearly 90%recov-ery,<1μg/L Co leaching)and practical applicability.This study provides an efficient,sludge-free,and solar-compatible strategy for eliminating persistent herbicides in water treatment.
文摘Background: Cyanobacteria phycocyanins (Cps) have already shown powerful antioxidant properties. In human cells submitted to oxidative stress the telomeres length decrease, the expression of progerin and the activity of mTOR are increased. At our knowledge, there is no published data on Cps correlated with ultraviolet radiation (UV) and blue light effects in human cells regarding telomeres’ length, progerin expression or mTOR1 complex activity. Objectives: In this study, we sought to assess 1) telomeres’ length in newborn human fibroblasts exposed to UV and blue light;2) progerin production in mature human normal fibroblasts exposed to UV;3) mTOR1 activation in adult human normal keratinocytes exposed to UV, analyzing the activity of a Cyanobacteria phycocyanin (Cp) in these in vitro models. Materials and Methods: Human skin fibroblasts or human normal keratinocytes were cultured—in the absence or in the presence of Cp and submitted to UVB + UVA and blue light irradiations. Telomeres’ length, progerin expression and mTOR1 activity were then assessed by molecular biology and immuno-enzymatic methods. Results: In cultured fibroblasts exposed to irradiations and treated by Cp, telomeres’ shortage and progerin expression were lower compared to irradiated untreated cells. In cultured keratinocytes treated by Cp and exposed to irradiations, the mTOR activity was lower compared to irradiated untreated cells. Conclusions: In these in vitro studies on human skin fibroblasts and on normal human keratinocytes, the cyanobacteria phycocyanin (Cp) showed a decrease of damages induced by UV and blue light expressed by telomeres preservation and downregulation of progerin expression and of mTOR activity, thus showing skin anti-aging and photo-protective potential.
