The ubiquitination of proteins,followed by their degradation via the proteasome or autophagosome,is a key mechanism for the posttranslational regulation of proteins in cells.The specificity of this process is primaril...The ubiquitination of proteins,followed by their degradation via the proteasome or autophagosome,is a key mechanism for the posttranslational regulation of proteins in cells.The specificity of this process is primarily dictated by the E3 ubiquitin ligases,which are classified into three main types:the really interesting new gene(RING),the RING-between-RING(RBR),and the homologous to the human papillomavirus E6 protein-associated protein(E6-AP)carboxyl terminus(HECT).Among the RING-type E3 ubiquitin ligases are the membrane-associated or membrane-proximal RING-CH(MARCH)proteins,which regulate the trafficking and levels of cellular and viral proteins,including immune receptors,innate immune response proteins,and viral glycoproteins[1].Eleven MARCH proteins,named MARCH1-11,are encoded in the human genome,and some of them(primarily MARCH8 along with MARCH1 and MARCH2)have been implicated in antiviral defense against RNA viruses such as human immunodeficiency virus(HIV-1),influenza virus,Ebola virus,SARS-CoV-2,and respiratory syncytial virus(RSV)[2].展开更多
基金partly supported by the United States National Institutes of Health(P20 GM134974 to RKJ).
文摘The ubiquitination of proteins,followed by their degradation via the proteasome or autophagosome,is a key mechanism for the posttranslational regulation of proteins in cells.The specificity of this process is primarily dictated by the E3 ubiquitin ligases,which are classified into three main types:the really interesting new gene(RING),the RING-between-RING(RBR),and the homologous to the human papillomavirus E6 protein-associated protein(E6-AP)carboxyl terminus(HECT).Among the RING-type E3 ubiquitin ligases are the membrane-associated or membrane-proximal RING-CH(MARCH)proteins,which regulate the trafficking and levels of cellular and viral proteins,including immune receptors,innate immune response proteins,and viral glycoproteins[1].Eleven MARCH proteins,named MARCH1-11,are encoded in the human genome,and some of them(primarily MARCH8 along with MARCH1 and MARCH2)have been implicated in antiviral defense against RNA viruses such as human immunodeficiency virus(HIV-1),influenza virus,Ebola virus,SARS-CoV-2,and respiratory syncytial virus(RSV)[2].
