基金supported by the National Key Research and Development Program of China(2022YFC3401500 to Y.Z.and Y.S.,2021YFA1101000 to Y.S.)the National Natural Science Foundation of China(32471300,92053117,and 81972591 to Y.Z.,92253203 and U22A20317 to Y.S.,81974429 and 82172898 to X.X.)+1 种基金the Natural Science Foundation of Zhejiang Province(LZ22H160003 to Y.Z.,LD22H300003 to Y.S.)the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2022R01002 to Y.S.).
文摘SMURF1(Smad ubiquitination regulatory factor 1),a HECT-type E3 ubiquitin ligase,plays pivotal regulatory roles in numerous biological processes,encompassing apoptosis,senescence,cell cycle progression,metastasis,and genomic stability,by targeting a variety of key signaling and regulatory proteins for ubiquitylation and proteasome degradation(Fu et al.,2020).
