Dear Editor,The Shank gene family(SHANK1,SHANK2,and SHANK3)comprises high-risk genetic contributors to autism spectrum disorders(ASD)(Durand et al.,2007;Monteiro and Feng,2017).Copy-number variants and truncating muta...Dear Editor,The Shank gene family(SHANK1,SHANK2,and SHANK3)comprises high-risk genetic contributors to autism spectrum disorders(ASD)(Durand et al.,2007;Monteiro and Feng,2017).Copy-number variants and truncating mutations in these genes have been identi ed in~1%of ASD patients(Leblond et al.,2014;Moessner et al.,2007).Research in Shank-de cient mouse models demonstrates that restoring Shank expression in adulthood can enhance synaptic protein levels,correct defects in synaptic morphology and function,and improve ASDrelated behavioral de cits(Guo et al.,2019;Mei et al.,2016).These ndings suggest that targeting the postsynaptic function of SHANK proteins may be a promising therapeutic strategy for ASD.展开更多
基金supported by grants from the National Natural Science Foundation of China(NSFC)(32330038,32394030)the Ministry of Science and Technology(STI2030-2021ZD0202300)。
文摘Dear Editor,The Shank gene family(SHANK1,SHANK2,and SHANK3)comprises high-risk genetic contributors to autism spectrum disorders(ASD)(Durand et al.,2007;Monteiro and Feng,2017).Copy-number variants and truncating mutations in these genes have been identi ed in~1%of ASD patients(Leblond et al.,2014;Moessner et al.,2007).Research in Shank-de cient mouse models demonstrates that restoring Shank expression in adulthood can enhance synaptic protein levels,correct defects in synaptic morphology and function,and improve ASDrelated behavioral de cits(Guo et al.,2019;Mei et al.,2016).These ndings suggest that targeting the postsynaptic function of SHANK proteins may be a promising therapeutic strategy for ASD.
