To the Editor,Immune-mediated necrotizing myopathy(IMNM)is a type of inflammatory myopathy subdivided into three major subtypes:anti-signal recognition particle(anti-SRP)IMNM,anti-3-hydroxy-3-methylglutaryl coenzyme A...To the Editor,Immune-mediated necrotizing myopathy(IMNM)is a type of inflammatory myopathy subdivided into three major subtypes:anti-signal recognition particle(anti-SRP)IMNM,anti-3-hydroxy-3-methylglutaryl coenzyme A reductase(anti-HMGCR)IMNM,and seronegative IMNM,which accounts for 10%–20%of cases.Patients usually present with subacute symmetrical muscle weakness,usually involving the proximal and pharyngeal muscles with sig-nificantly elevated creatinine kinase levels.Associated symptoms include myalgia,fatigue,and weight loss.^(1,2)Anti-SRP IMNM usually presents with a more fulminant course,with early dysphagia and possible respiratory failure,while this is rarer in anti-HMGCR and seronegative IMNM.Notably,seronegative IMNM is linked to malignancy,resulting in decreased survival.^(3)展开更多
文摘To the Editor,Immune-mediated necrotizing myopathy(IMNM)is a type of inflammatory myopathy subdivided into three major subtypes:anti-signal recognition particle(anti-SRP)IMNM,anti-3-hydroxy-3-methylglutaryl coenzyme A reductase(anti-HMGCR)IMNM,and seronegative IMNM,which accounts for 10%–20%of cases.Patients usually present with subacute symmetrical muscle weakness,usually involving the proximal and pharyngeal muscles with sig-nificantly elevated creatinine kinase levels.Associated symptoms include myalgia,fatigue,and weight loss.^(1,2)Anti-SRP IMNM usually presents with a more fulminant course,with early dysphagia and possible respiratory failure,while this is rarer in anti-HMGCR and seronegative IMNM.Notably,seronegative IMNM is linked to malignancy,resulting in decreased survival.^(3)
