The use of metal oxides has been extensively documented in the literature and applied in a variety of contexts,including but not limited to energy storage,chemical sensors,and biomedical applications.One of the most s...The use of metal oxides has been extensively documented in the literature and applied in a variety of contexts,including but not limited to energy storage,chemical sensors,and biomedical applications.One of the most significant applications of metal oxides is heterogeneous catalysis,which represents a pivotal technology in industrial production on a global scale.Catalysts serve as the primary enabling agents for chemical reactions,and among the plethora of catalysts,metal oxides including magnesium oxide(MgO),ceria(CeO_(2))and titania(TiO_(2)),have been identified to be particularly effective in catalyzing a variety of reactions[1].Theoretical calculations based on density functional theory(DFT)and a multitude of other quantum chemistry methods have proven invaluable in elucidating the mechanisms of metal-oxide-catalyzed reactions,thereby facilitating the design of high-performance catalysts[2].展开更多
A Level考试素有“英国高考”之称。其制度演进大致经历了发轫与探索、扩张与调适、回归与重塑三个阶段,其主要变革内容包括四个方面:组织形式从年终末考的线性考试模式发展为一年多考的模块化考试,再回归线性考试模式;考试评价从常模...A Level考试素有“英国高考”之称。其制度演进大致经历了发轫与探索、扩张与调适、回归与重塑三个阶段,其主要变革内容包括四个方面:组织形式从年终末考的线性考试模式发展为一年多考的模块化考试,再回归线性考试模式;考试评价从常模参照转变为标准参照,评价手段逐步优化;考试要求从注重学科深度转变为强调知识广度,再发展为追求广度和深度并重;考试内容从偏重学术性转变为普职并重,再发展为职普融通和强调基础学科。变革的动因既有来自外部的国际竞争加剧和国内政党轮替,也有来自内部的文化价值观驱动和考试选才效度追求。A Level考试制度对我国高考改革有一定启发,我国可结合国情,以基础学科为支点、职普融通为路径、多样化的考试选择为依托、预测效度为导向,开展本土化探索。展开更多
Accurate prediction of rockburst intensity levels is crucial for ensuring the safety of deep hard rock engineering construction.This paper introduced an expert system for rockburst intensity level prediction that empl...Accurate prediction of rockburst intensity levels is crucial for ensuring the safety of deep hard rock engineering construction.This paper introduced an expert system for rockburst intensity level prediction that employs machine learning algorithms as the basis for its inference rules.The system comprises four modules:a database,a repository,an inference engine,and an interpreter.A database containing 1114 rockburst cases was used to construct 357 datasets that serve as the repository for the expert system.Additionally,19 types of machine learning algorithms were used to establish 6783 micro-models to construct cognitive rules within the inference engine.By integrating probability theory and marginal analysis,a fuzzy scoring method based on the SoftMax function was developed and applied to the interpreter for rockburst intensity level prediction,effectively restoring the continuity of rockburst characteristics.The research results indicate that ensemble algorithms based on decision trees are more effective in capturing the characteristics of rockburst.Key factors for accurate prediction of rockburst intensity include uniaxial compressive strength,elastic energy index,the maximum principal stress,tangential stress,and their composite indicators.The accuracy of the proposed rockburst intensity level prediction expert system was verified using 20 engineering rockburst cases,with predictions aligning closely with the actual rockburst intensity levels.展开更多
This study aims to explore the impact of fatigue induced by different limb exercises on cerebral cortical oxygenation levels and functional connectivity strength using functional near-infrared spectroscopy(fNIRS).Fati...This study aims to explore the impact of fatigue induced by different limb exercises on cerebral cortical oxygenation levels and functional connectivity strength using functional near-infrared spectroscopy(fNIRS).Fatigue was induced using an upper limb ergometer or a lower limb ergometer,with the load increasing gradually each minute.fNIRS covering the prefrontal cortex and motor cortex were used to collect data during the resting state,both before and after fatigue induction.A two-way ANOVA was conducted to examine differences in oxyhemoglobin(HbO_(2))and functional connectivity before and after fatigue induction in both groups,with the significance level set at 0.05.Exercise-induced fatigue in both the upper and lower limbs leads to a significant decrease in cerebral cortical oxygenation levels.Upper limb fatigue leads to a significant reduction in functional connectivity,there were significant decreases in connectivity within the motor cortex,between the motor cortex and frontal regions,and between the right ventrolateral prefrontal cortex and other frontal regions.Conversely,no significant changes were observed before and after lower limb fatigue.Future studies should focus on examining the extent to which how changes in the cerebral cortex,induced by exercise fatigue,are linked to exercise-and/or performance-related outcomes.展开更多
Hainan Province in south China is the country’s second-largest island and the largest free trade port by area.It has entered a historic phase in China’s drive to promote high-level institutional opening up.On 18 Dec...Hainan Province in south China is the country’s second-largest island and the largest free trade port by area.It has entered a historic phase in China’s drive to promote high-level institutional opening up.On 18 December 2025,Hainan officially launched island-wide special customs operations,commonly referred to as“customs closure.”From that date,goods entering or leaving the island,except those traded with the Chinese mainland,are subject to simplified customs procedures and potentially reduced or zero tariffs.展开更多
Groundwater level(GWL)is a key indicator used to accurately assess groundwater resources and form the foundation for ef-fective groundwater management.This paper integrates a Gate Recurrent Unit(GRU)model with a Multi...Groundwater level(GWL)is a key indicator used to accurately assess groundwater resources and form the foundation for ef-fective groundwater management.This paper integrates a Gate Recurrent Unit(GRU)model with a Multi-head Self-attention mechan-ism(MSAM-GRU)to simulate GWLs in both confined and unconfined aquifers simultaneously.The model innovatively captures the lag times between GWLs in the unconfined aquifer and precipitation,as well as between GWLs in the confined aquifer and the upper aquifer.We have assessed the effectiveness of the proposed model using a case study in the Beijing Plain,China from January 2005 to December 2020.With the consideration of lag times,the results indicated that the MSAM-GRU model exhibits a maximum 67%and 73%reduction in RMSE compared to the Attention mechanism-GRU(AM-GRU)and GRU model,respectively.MSAM-GRU model exhibited a 31%reduction in RMSE and a 0.12 increase in R^(2) compared to the same model that do not account for lag time.In Region I,the shortest lag time of GWL in the unconfined aquifer was two months,while that in the confined aquifer was three months,indicating a longer delayed response in the confined aquifer.MSAM-GRU model considering lag time,was then applied to simulate the GWLs in the unconfined aquifer under different scenarios and to analyze whether GWL fluctuations affect subway operations.The simulation res-ults showed that under the scenario 1,the GWL in the unconfined aquifer would rise above the depth of subway station floor,threaten-ing the operation of subways.This study can provide reliable technical support for the accurate simulation of GWLs in multi-aquifer systems.展开更多
According to climate features and river runoff conditions, Xinjiang could be divided into three research areas： The Altay-Tacheng region, the Tianshan Mountain region and the northern slope of the Kunlun Mountains. U...According to climate features and river runoff conditions, Xinjiang could be divided into three research areas： The Altay-Tacheng region, the Tianshan Mountain region and the northern slope of the Kunlun Mountains. Utilizing daily observations from 12 sounding stations and the annual runoff dataset from 34 hydrographical stations in Xinjiang for the period 1960-2002, the variance of the summertime 0℃ level height and the changing trends of river runoff are analyzed both qualitatively and quantitatively, through trend contrast of curves processed by a 5-point smoothing procedure and linear correlation. The variance of the summertime 0℃ level height in Xinjiang correlates well with that of the annual river runoff, especially since the early 1990s, but it differs from region to region, with both the average height of the 0℃ level and runoff quantity significantly increasing over time in the Al- tay-Tacheng and Tianshan Mountain regions but decreasing on the northern slope of the Kunlun Mountains. The correlation holds for the whole of Xinjiang as well as the three indi- vidual regions, with a 0.01 significance level. This indicates that in recent years, climate change in Xinjiang has affected not only the surface layer but also the upper levels of the atmosphere, and this raising and lowering of the summertime 0℃ level has a direct impact on the warming and wetting process in Xinjiang and the amount of river runoff. Warming due to climate change increases the height of the 0℃ level, but also speeds up, ice-snow melting in mountain regions, which in turn increases river runoff, leading to a season of plentiful water instead of the more normal low flow period.展开更多
BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants signif...BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants significantly improve the predictive sensitivity of TIL,more than 50%of cases of this toxicity cannot be predicted by this mutation.The potential use of the 6-thioguanine nucleotide(6TGN)level to predict TIL has been explored,but no decisive conclusion has been reached.Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 R139C genotypes?AIM To determine the 6TGN cut-off levels after dividing patients into subgroups according to their NUDT15 R139C genotypes.METHODS Patients’clinical and epidemiological characteristics were collected from medical records from July 2014 to February 2017.NUDT15 R139C,thiopurine S methyltransferase,and 6TGN concentrations were measured.RESULTS A total of 411 Crohn’s disease patients were included.TIL was observed in 72 individuals with a median 6TGN level of 323.4 pmol/8×10^8 red blood cells(RBC),which was not different from that of patients without TIL(P=0.071).Then,we compared the 6TGN levels based on NUDT15 R139C.For CC(n=342)and CT(n=65)genotypes,the median 6TGN level in patients with TIL was significantly higher than that in patients without(474.8 vs 306.0 pmol/8×10^8 RBC,P=9.4×10-^5;291.7 vs 217.6 pmol/8×10^8 RBC,P=0.039,respectively).The four TT carriers developed TIL,with a median 6TGN concentration of 135.8 pmol/8×10^8 RBC.The 6TGN cut-off levels were 411.5 and 319.2 pmol/8×108 RBC for the CC and CT groups,respectively.CONCLUSION The predictive sensitivity of TIL based on 6TGN is dramatically increased after subgrouping according to NUDT15 R139C genotypes.Applying 6TGN cut-off levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.展开更多
This study focuses on sedimentary environmental changes offshore of Hangzhou Bay, East China, since the Late Quaternary. AMS ^14C ages from core CJK10, lithologies, distribution of foraminifera, heavy minerals, and S ...This study focuses on sedimentary environmental changes offshore of Hangzhou Bay, East China, since the Late Quaternary. AMS ^14C ages from core CJK10, lithologies, distribution of foraminifera, heavy minerals, and S and C1 elements show a fluvial terrace environment during -23.2-11.0 cal ka BP; a littoral to tidal-flat environment during 11.0-10.2 cal ka BP; and a shallow marine environment with a relatively low sedimentation rate （0.1-0.22 cm/a） since 4.3 cal ka BP. High depositional rates （-1.6 cm/a） from 10.9 to 10.2 cal ka BP resulted from sufficient accommodation space created by rapid sea level rise from -44 m to -33 m, from high sediment delivery by local rivers, and effective trapping of sediments by tidal-flat vegetation. The rate of sea level rise was variable; relatively high from 10.9 to 10.6 cal ka BP （2.1 cm/a）, and lower since 10.6 cal ka BP （1.2 cm/a）. The Changjiang alongshore current crossed the Hangzhou Bay to form the mud wedge on the inner shelf of the East China Sea later than 9.4 cal ka BP. The CJK10 site was a tide-dominated shelf environment and experienced erosion from approximately 9.4-9.2 cal ka BP to 4.3 cal ka BP. The depositional hiatus was caused by the Changjiang alongshore current, which was relatively weak during 9.4-7.5 cal ka BP and increased in strength during -7.5-4 cal ka BP. From -4.3 cal ka BP, a large amount of sediment from the Changjiang River was partly deposited on the continental shelf of Hangzhou Bay with some transported southward. Therefore, this study clarifies the history of Changjiang-derived sediment dispersal and deposition, although a detailed record of the changes in the Chang3iang alongshore current since 4.3 cal ka BP is difficult to obtain because of the scarcity of evidence.展开更多
In 1994,Townend proposed a method to calculate the relative changes in various wave characteristics and structure-related parameters due to sea level rise for regular waves.The method was extended to irregular waves b...In 1994,Townend proposed a method to calculate the relative changes in various wave characteristics and structure-related parameters due to sea level rise for regular waves.The method was extended to irregular waves by Cheon and Suh in 2016.In this study,this method is further extended to include the effect of future change in offshore wave height and the sea level rise.The relative changes in wavelength,refraction coefficient,shoaling coefficient,and wave height in nearshore area are presented as functions of the relative changes in water depth and offshore wave height.The calculated relative changes in wave characteristics are then used to estimate the effect of sea level rise and offshore wave height change on coastal structures by calculating the relative changes in wave run-up height,overtopping discharge,crest freeboard,and armor weight of the structures.The relative changes in wave characteristics and structure-related parameters are all expressed as a function of the relative water depth for various combinations of the relative changes in water depth and offshore wave height.展开更多
The humans’ need to use the oceans for exploration and extraction of oil has led to the development of engineering science in the field of offshore structures. Since it’s important to examine the offshore structures...The humans’ need to use the oceans for exploration and extraction of oil has led to the development of engineering science in the field of offshore structures. Since it’s important to examine the offshore structures from different aspects and perspectives, we would have to evaluate many different parameters about them. So categorizing these parameters can help to perform their related analysis with more accuracy and more details. Due to the efficient force it exerts on the structure, the pressure distribution around every marine or hydraulic structure has a significant importance, and it even accounts for one of the dominant issues in designing and building of such structures. In the present study, an oil platform located in Phase 15 of South Pars oil fields, located in the Persian Gulf waters, has been analyzed using the FLOW 3D software. The outputs indicate that the pressure of water is distributed almost hydrostatically with the depth, and its maximum reaches 0.6 MPa at the bottom.展开更多
Tide gauge data are used to investigate sea level variability offthe northwest coast of the South China Sea （SCS） in 2012, and a significant sea level elevation with a magnitude approaching 79 mm is observed. Analys...Tide gauge data are used to investigate sea level variability offthe northwest coast of the South China Sea （SCS） in 2012, and a significant sea level elevation with a magnitude approaching 79 mm is observed. Analysis suggests that an abnormal sea surface heat flux and freshwater flux may have contributed to this abnormal rise in sea level, together with the remote influence of an ENSO event. Further investigation shows that the event was dominated by the positive freshwater flux, where large volumes of water entered the ocean, and a maximum is centered to the south of Guangdong province, China. Simultaneously, a positive anomalous heat flux occurred in the northwestern part of the SCS, which is considered to have made a positive contribution to the high local sea level elevation. In addition to the heat flux, the ENSO event also had a significant effect on the event, where the La Nifia-induced northwest Pacific cyclone contributed to sea level rise over the northwestern SCS through dynamic and thermodynamic interactions.展开更多
API code is introduced at first, and then a comparison of seismic character and seismic hazard between Bohai and Southern California is carried out. The analysis indicates both the seismic frequency and intensity and ...API code is introduced at first, and then a comparison of seismic character and seismic hazard between Bohai and Southern California is carried out. The analysis indicates both the seismic frequency and intensity and the seismic hazard of Bohai are much weaker than that of Southern California. API code states the strength level and deformation level of permanent structures in Southern California takes 200 a and several hundred to a few thousand years respectively. But in the reference codes in China, the seismic levels take 500 a and 10000 a for strength design and deformation design, and it seems too conservative. In China, the deformation level of class A structure takes 2%-3% probabilities of exceedance in reference period 100 a, and that of class B and C often takes 2%-3% in 50 a. Now that offshore platforms may cause server subsequent risk, it is safe to take 1% in 30 a as its deformation design level. On the basis of the above analyses and social economic level and the consistency with present codes, the strength design level and deformation design level of Chinese offshore platforms is suggested to take 200 a and 3000 a respectively.展开更多
The promotion of deep decarbonization in the cement industry is crucial for mitigating global climate change,a key component of which is carbon capture,utilization,and storage(CCUS)technology.Despite its importance,th...The promotion of deep decarbonization in the cement industry is crucial for mitigating global climate change,a key component of which is carbon capture,utilization,and storage(CCUS)technology.Despite its importance,there is a lack of empirical assessments of early opportunities for CCUS implementation in the cement sector.In this study,a comprehensive onshore and offshore source–sink matching optimization assessment framework for CCUS retrofitting in the cement industry,called the SSM-Cement framework,is proposed.The framework comprises four main modules:the cement plant suitability screening module,the storage site assessment module,the source–sink matching optimization model module,and the economic assessment module.By applying this framework to China,919 candidates are initially screened from 1132 existing cement plants.Further,603 CCUS-ready cement plants are identified,and are found to achieve a cumulative emission reduction of 18.5 Gt CO_(2) from 2030 to 2060 by meeting the CCUS feasibility conditions for constructing both onshore and offshore CO_(2) transportation routes.The levelized cost of cement(LCOC)is found to range from 30 to 96(mean 73)USD·(t cement)^(-1),while the levelized carbon avoidance cost(LCAC)ranges from^(-5) to 140(mean 88)USD·(t CO_(2))^(-1).The northeastern and northwestern regions of China are considered priority areas for CCUS implementation,with the LCAC concentrated in the range of 35 to 70 USD·(t CO_(2))^(-1).In addition to onshore storage of 15.8 Gt CO_(2) from 2030 to 2060,offshore storage would contribute 2.7 Gt of decarbonization for coastal cement plants,with comparable LCACs around 90 USD·(t CO_(2))^(-1).展开更多
Accurate prediction of water level changes in reservoirs is crucial for optimizing the operation of reservoir projects and ensuring their safety.This study proposed a method for reservoir water level prediction based ...Accurate prediction of water level changes in reservoirs is crucial for optimizing the operation of reservoir projects and ensuring their safety.This study proposed a method for reservoir water level prediction based on CEEMDAN-FE and RUN-SVM-RBFNN algorithms.By integrating the adaptive complete ensemble empirical mode decomposition with adaptive noise(CEEMDAN)method and fuzzy entropy(FE)with the new and highly efficient Runge–Kuta optimizer(RUN),adaptive parameter optimization for the support vector machine(SVM)and radial basis function neural network(RBFNN)algorithms was achieved.Regression prediction was conducted on the two reconstructed sequences using SVM and RBFNN according to their respective features.This approach improved the accuracy and stability of predictions.In terms of accuracy,the combined model outperformed single models,with the determination coefficient,root mean square error,and mean absolute error values of 0.9975,0.2418 m,and 0.1616 m,respectively.In terms of stability,the model predicted more consistently in training and testing periods,with stable overall prediction accuracy and a better adaptive ability to complex datasets.The case study demonstrated that the combined prediction model effectively addressed the environmental factors affecting reservoir water levels,leveraged the strength of each predictive method,compensated for their limitations,and clarified the impacts of environmental factors on reservoir water levels.展开更多
Metallogenic research on structural levels can reveal vertical patterns of mineralization and facilitate the deep exploration of economic minerals.However,research focusing on the correlation between structural levels...Metallogenic research on structural levels can reveal vertical patterns of mineralization and facilitate the deep exploration of economic minerals.However,research focusing on the correlation between structural levels and mineralization remains limited.In this study,we summarize the deformation patterns and associated mineral deposits observed at different crustal levels(i.e.,surface,shallow,middle,and deep structural levels,corresponding to depths of<2,2-8,8-15,and>15 km,respectively).Furthermore,we examine the genetic association between structural levels and metallogenesis,demonstrating that distinct structural levels are linked to specific types of mineralization.Key factors that vary across crustal levels include temperature,pressure,and fluid circulation.Ore-forming processes involve interactions between structures and fluids under varying temperatures and pressures.Structural levels influence mineralization by controlling the temperatures,pressures,and deformation mechanisms that drive the activation,migration,and enrichment of ore-forming materials.展开更多
To explore water level variations and their dynamic influence on the water quality of Huayang Lakes,the water level from 1967 to 2023 and water quality from 2015 to 2023 were analyzed using the Mann–Kendall trend tes...To explore water level variations and their dynamic influence on the water quality of Huayang Lakes,the water level from 1967 to 2023 and water quality from 2015 to 2023 were analyzed using the Mann–Kendall trend test,box plots,and violin plots.The results show a notable hydrological rhythm of water level alternation between dry and flood seasons in Huayang Lakes,with an average water level of 12.82 m and a monthly range of 11.21–17.24m.Since 2017,the water level of Huayang Rivers has shown a decreasing trend of–0.02 m/a.Total phosphorus(TP)has become the primary pollutant.The TP concentrations in Longgan Lake(the largest lake)during the dry,rising,flood,and retreating seasons from 2015 to 2023were 0.083,0.061,0.050,and 0.059 mg/L,respectively.The effect of water level on TP was mainly observed during the low-water period.When the water level in the dry season rose to 12.25 and 13.00 m,the percentage of TP exceeding 0.1 mg/L in Longgan Lake decreased to 55.8%and 33.3%,respectively.During the dry season,wind and wave disturbances caused the release of endogenous phosphorus in Huayang Lakes.This led to drastic fluctuations in TP concentration,reducing the correlation between water level and TP.When external control is limited,the water level during the dry season should be maintained between 12.25 and 13.0 m.Additionally,it is necessary to accelerate the restoration of submerged macrophyte species(such as Hydrilla verticillata and Vallisneria natans)in the Huayang Rivers.展开更多
For the diagnostics and health management of lithium-ion batteries,numerous models have been developed to understand their degradation characteristics.These models typically fall into two categories:data-driven models...For the diagnostics and health management of lithium-ion batteries,numerous models have been developed to understand their degradation characteristics.These models typically fall into two categories:data-driven models and physical models,each offering unique advantages but also facing limitations.Physics-informed neural networks(PINNs)provide a robust framework to integrate data-driven models with physical principles,ensuring consistency with underlying physics while enabling generalization across diverse operational conditions.This study introduces a PINN-based approach to reconstruct open circuit voltage(OCV)curves and estimate key ageing parameters at both the cell and electrode levels.These parameters include available capacity,electrode capacities,and lithium inventory capacity.The proposed method integrates OCV reconstruction models as functional components into convolutional neural networks(CNNs)and is validated using a public dataset.The results reveal that the estimated ageing parameters closely align with those obtained through offline OCV tests,with errors in reconstructed OCV curves remaining within 15 mV.This demonstrates the ability of the method to deliver fast and accurate degradation diagnostics at the electrode level,advancing the potential for precise and efficient battery health management.展开更多
基金financial support from the National Key R&D Program of China(2021YFB3500700)the National Natural Science Foundation of China(22473042,22003016,and 92145302).
文摘The use of metal oxides has been extensively documented in the literature and applied in a variety of contexts,including but not limited to energy storage,chemical sensors,and biomedical applications.One of the most significant applications of metal oxides is heterogeneous catalysis,which represents a pivotal technology in industrial production on a global scale.Catalysts serve as the primary enabling agents for chemical reactions,and among the plethora of catalysts,metal oxides including magnesium oxide(MgO),ceria(CeO_(2))and titania(TiO_(2)),have been identified to be particularly effective in catalyzing a variety of reactions[1].Theoretical calculations based on density functional theory(DFT)and a multitude of other quantum chemistry methods have proven invaluable in elucidating the mechanisms of metal-oxide-catalyzed reactions,thereby facilitating the design of high-performance catalysts[2].
基金Project(42077244)supported by the National Natural Science Foundation of ChinaProject(2020-05)supported by the Open Research Fund of Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization,China。
文摘Accurate prediction of rockburst intensity levels is crucial for ensuring the safety of deep hard rock engineering construction.This paper introduced an expert system for rockburst intensity level prediction that employs machine learning algorithms as the basis for its inference rules.The system comprises four modules:a database,a repository,an inference engine,and an interpreter.A database containing 1114 rockburst cases was used to construct 357 datasets that serve as the repository for the expert system.Additionally,19 types of machine learning algorithms were used to establish 6783 micro-models to construct cognitive rules within the inference engine.By integrating probability theory and marginal analysis,a fuzzy scoring method based on the SoftMax function was developed and applied to the interpreter for rockburst intensity level prediction,effectively restoring the continuity of rockburst characteristics.The research results indicate that ensemble algorithms based on decision trees are more effective in capturing the characteristics of rockburst.Key factors for accurate prediction of rockburst intensity include uniaxial compressive strength,elastic energy index,the maximum principal stress,tangential stress,and their composite indicators.The accuracy of the proposed rockburst intensity level prediction expert system was verified using 20 engineering rockburst cases,with predictions aligning closely with the actual rockburst intensity levels.
基金supported by National Natural Science Foundation of China[NO.11932013].
文摘This study aims to explore the impact of fatigue induced by different limb exercises on cerebral cortical oxygenation levels and functional connectivity strength using functional near-infrared spectroscopy(fNIRS).Fatigue was induced using an upper limb ergometer or a lower limb ergometer,with the load increasing gradually each minute.fNIRS covering the prefrontal cortex and motor cortex were used to collect data during the resting state,both before and after fatigue induction.A two-way ANOVA was conducted to examine differences in oxyhemoglobin(HbO_(2))and functional connectivity before and after fatigue induction in both groups,with the significance level set at 0.05.Exercise-induced fatigue in both the upper and lower limbs leads to a significant decrease in cerebral cortical oxygenation levels.Upper limb fatigue leads to a significant reduction in functional connectivity,there were significant decreases in connectivity within the motor cortex,between the motor cortex and frontal regions,and between the right ventrolateral prefrontal cortex and other frontal regions.Conversely,no significant changes were observed before and after lower limb fatigue.Future studies should focus on examining the extent to which how changes in the cerebral cortex,induced by exercise fatigue,are linked to exercise-and/or performance-related outcomes.
文摘Hainan Province in south China is the country’s second-largest island and the largest free trade port by area.It has entered a historic phase in China’s drive to promote high-level institutional opening up.On 18 December 2025,Hainan officially launched island-wide special customs operations,commonly referred to as“customs closure.”From that date,goods entering or leaving the island,except those traded with the Chinese mainland,are subject to simplified customs procedures and potentially reduced or zero tariffs.
基金Under the auspices of the National Key Research and Development Program of China(No.2024YFC3713102)。
文摘Groundwater level(GWL)is a key indicator used to accurately assess groundwater resources and form the foundation for ef-fective groundwater management.This paper integrates a Gate Recurrent Unit(GRU)model with a Multi-head Self-attention mechan-ism(MSAM-GRU)to simulate GWLs in both confined and unconfined aquifers simultaneously.The model innovatively captures the lag times between GWLs in the unconfined aquifer and precipitation,as well as between GWLs in the confined aquifer and the upper aquifer.We have assessed the effectiveness of the proposed model using a case study in the Beijing Plain,China from January 2005 to December 2020.With the consideration of lag times,the results indicated that the MSAM-GRU model exhibits a maximum 67%and 73%reduction in RMSE compared to the Attention mechanism-GRU(AM-GRU)and GRU model,respectively.MSAM-GRU model exhibited a 31%reduction in RMSE and a 0.12 increase in R^(2) compared to the same model that do not account for lag time.In Region I,the shortest lag time of GWL in the unconfined aquifer was two months,while that in the confined aquifer was three months,indicating a longer delayed response in the confined aquifer.MSAM-GRU model considering lag time,was then applied to simulate the GWLs in the unconfined aquifer under different scenarios and to analyze whether GWL fluctuations affect subway operations.The simulation res-ults showed that under the scenario 1,the GWL in the unconfined aquifer would rise above the depth of subway station floor,threaten-ing the operation of subways.This study can provide reliable technical support for the accurate simulation of GWLs in multi-aquifer systems.
基金Special Fund for Social Public Good Project of the Ministry of Science and Technology,No.IDM200603National Basic Research Program of China (973 Program), No.2010CB951001 National Natural Science Foundation of China,No.41075050,No.40775019 No.40875010
文摘According to climate features and river runoff conditions, Xinjiang could be divided into three research areas： The Altay-Tacheng region, the Tianshan Mountain region and the northern slope of the Kunlun Mountains. Utilizing daily observations from 12 sounding stations and the annual runoff dataset from 34 hydrographical stations in Xinjiang for the period 1960-2002, the variance of the summertime 0℃ level height and the changing trends of river runoff are analyzed both qualitatively and quantitatively, through trend contrast of curves processed by a 5-point smoothing procedure and linear correlation. The variance of the summertime 0℃ level height in Xinjiang correlates well with that of the annual river runoff, especially since the early 1990s, but it differs from region to region, with both the average height of the 0℃ level and runoff quantity significantly increasing over time in the Al- tay-Tacheng and Tianshan Mountain regions but decreasing on the northern slope of the Kunlun Mountains. The correlation holds for the whole of Xinjiang as well as the three indi- vidual regions, with a 0.01 significance level. This indicates that in recent years, climate change in Xinjiang has affected not only the surface layer but also the upper levels of the atmosphere, and this raising and lowering of the summertime 0℃ level has a direct impact on the warming and wetting process in Xinjiang and the amount of river runoff. Warming due to climate change increases the height of the 0℃ level, but also speeds up, ice-snow melting in mountain regions, which in turn increases river runoff, leading to a season of plentiful water instead of the more normal low flow period.
基金Supported by the National Natural Science Foundation of China,No.81573507,No.81473283,No.81173131,and No.81320108027Guangdong Provincial Key Laboratory Construction Foundation,No.2017B030314030+1 种基金The National Key Research and Development Program,No.2016YFC0905003the 111 Project,No.B16047
文摘BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants significantly improve the predictive sensitivity of TIL,more than 50%of cases of this toxicity cannot be predicted by this mutation.The potential use of the 6-thioguanine nucleotide(6TGN)level to predict TIL has been explored,but no decisive conclusion has been reached.Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 R139C genotypes?AIM To determine the 6TGN cut-off levels after dividing patients into subgroups according to their NUDT15 R139C genotypes.METHODS Patients’clinical and epidemiological characteristics were collected from medical records from July 2014 to February 2017.NUDT15 R139C,thiopurine S methyltransferase,and 6TGN concentrations were measured.RESULTS A total of 411 Crohn’s disease patients were included.TIL was observed in 72 individuals with a median 6TGN level of 323.4 pmol/8×10^8 red blood cells(RBC),which was not different from that of patients without TIL(P=0.071).Then,we compared the 6TGN levels based on NUDT15 R139C.For CC(n=342)and CT(n=65)genotypes,the median 6TGN level in patients with TIL was significantly higher than that in patients without(474.8 vs 306.0 pmol/8×10^8 RBC,P=9.4×10-^5;291.7 vs 217.6 pmol/8×10^8 RBC,P=0.039,respectively).The four TT carriers developed TIL,with a median 6TGN concentration of 135.8 pmol/8×10^8 RBC.The 6TGN cut-off levels were 411.5 and 319.2 pmol/8×108 RBC for the CC and CT groups,respectively.CONCLUSION The predictive sensitivity of TIL based on 6TGN is dramatically increased after subgrouping according to NUDT15 R139C genotypes.Applying 6TGN cut-off levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.
基金Supported by the National Special Research Fund for Non-Profit Marine Sector(No.200805063)the Continental Shelf Drilling Program(No.GZH201100202)the State Key Laboratory of Marine Geology and Environment,Institute of Oceanology Program(No.MGE2012KG09)
文摘This study focuses on sedimentary environmental changes offshore of Hangzhou Bay, East China, since the Late Quaternary. AMS ^14C ages from core CJK10, lithologies, distribution of foraminifera, heavy minerals, and S and C1 elements show a fluvial terrace environment during -23.2-11.0 cal ka BP; a littoral to tidal-flat environment during 11.0-10.2 cal ka BP; and a shallow marine environment with a relatively low sedimentation rate （0.1-0.22 cm/a） since 4.3 cal ka BP. High depositional rates （-1.6 cm/a） from 10.9 to 10.2 cal ka BP resulted from sufficient accommodation space created by rapid sea level rise from -44 m to -33 m, from high sediment delivery by local rivers, and effective trapping of sediments by tidal-flat vegetation. The rate of sea level rise was variable; relatively high from 10.9 to 10.6 cal ka BP （2.1 cm/a）, and lower since 10.6 cal ka BP （1.2 cm/a）. The Changjiang alongshore current crossed the Hangzhou Bay to form the mud wedge on the inner shelf of the East China Sea later than 9.4 cal ka BP. The CJK10 site was a tide-dominated shelf environment and experienced erosion from approximately 9.4-9.2 cal ka BP to 4.3 cal ka BP. The depositional hiatus was caused by the Changjiang alongshore current, which was relatively weak during 9.4-7.5 cal ka BP and increased in strength during -7.5-4 cal ka BP. From -4.3 cal ka BP, a large amount of sediment from the Changjiang River was partly deposited on the continental shelf of Hangzhou Bay with some transported southward. Therefore, this study clarifies the history of Changjiang-derived sediment dispersal and deposition, although a detailed record of the changes in the Chang3iang alongshore current since 4.3 cal ka BP is difficult to obtain because of the scarcity of evidence.
基金National Research Foundation of Korea(NRF)funded by Korea Ministry of Science,ICT and Future Planning(NRF-2014R1A2A2A01007921)
文摘In 1994,Townend proposed a method to calculate the relative changes in various wave characteristics and structure-related parameters due to sea level rise for regular waves.The method was extended to irregular waves by Cheon and Suh in 2016.In this study,this method is further extended to include the effect of future change in offshore wave height and the sea level rise.The relative changes in wavelength,refraction coefficient,shoaling coefficient,and wave height in nearshore area are presented as functions of the relative changes in water depth and offshore wave height.The calculated relative changes in wave characteristics are then used to estimate the effect of sea level rise and offshore wave height change on coastal structures by calculating the relative changes in wave run-up height,overtopping discharge,crest freeboard,and armor weight of the structures.The relative changes in wave characteristics and structure-related parameters are all expressed as a function of the relative water depth for various combinations of the relative changes in water depth and offshore wave height.
文摘The humans’ need to use the oceans for exploration and extraction of oil has led to the development of engineering science in the field of offshore structures. Since it’s important to examine the offshore structures from different aspects and perspectives, we would have to evaluate many different parameters about them. So categorizing these parameters can help to perform their related analysis with more accuracy and more details. Due to the efficient force it exerts on the structure, the pressure distribution around every marine or hydraulic structure has a significant importance, and it even accounts for one of the dominant issues in designing and building of such structures. In the present study, an oil platform located in Phase 15 of South Pars oil fields, located in the Persian Gulf waters, has been analyzed using the FLOW 3D software. The outputs indicate that the pressure of water is distributed almost hydrostatically with the depth, and its maximum reaches 0.6 MPa at the bottom.
基金jointly funded by the National Key R&D Program of China(No.2017YFC1405100)the Basic Scientific Fund for National Public Research Institutes of China(No.2017S02)+3 种基金the Global Change and Air-Sea Interaction Program(Nos.GASI-IPOVAI-03,GASI-IPOVAI-02,GASI-02-IND-STSaut,and GASI-02-IND-STSwin)the China Postdoctoral Science Foundation(No.2017M612166)the China Ocean Mineral Resources R&D Association Project(No.DY135-E2-4-02)the NSFC-Shandong Joint Fund for Marine Science Research Centers(No.U1406404)
文摘Tide gauge data are used to investigate sea level variability offthe northwest coast of the South China Sea （SCS） in 2012, and a significant sea level elevation with a magnitude approaching 79 mm is observed. Analysis suggests that an abnormal sea surface heat flux and freshwater flux may have contributed to this abnormal rise in sea level, together with the remote influence of an ENSO event. Further investigation shows that the event was dominated by the positive freshwater flux, where large volumes of water entered the ocean, and a maximum is centered to the south of Guangdong province, China. Simultaneously, a positive anomalous heat flux occurred in the northwestern part of the SCS, which is considered to have made a positive contribution to the high local sea level elevation. In addition to the heat flux, the ENSO event also had a significant effect on the event, where the La Nifia-induced northwest Pacific cyclone contributed to sea level rise over the northwestern SCS through dynamic and thermodynamic interactions.
基金Important Research of the Tenth Five-year Plan from China Earthquake Administration ″Seismic hazard assessment and structure seismic fortification″ and ″Reliability of seismic fortification level of offshore platforms″.
文摘API code is introduced at first, and then a comparison of seismic character and seismic hazard between Bohai and Southern California is carried out. The analysis indicates both the seismic frequency and intensity and the seismic hazard of Bohai are much weaker than that of Southern California. API code states the strength level and deformation level of permanent structures in Southern California takes 200 a and several hundred to a few thousand years respectively. But in the reference codes in China, the seismic levels take 500 a and 10000 a for strength design and deformation design, and it seems too conservative. In China, the deformation level of class A structure takes 2%-3% probabilities of exceedance in reference period 100 a, and that of class B and C often takes 2%-3% in 50 a. Now that offshore platforms may cause server subsequent risk, it is safe to take 1% in 30 a as its deformation design level. On the basis of the above analyses and social economic level and the consistency with present codes, the strength design level and deformation design level of Chinese offshore platforms is suggested to take 200 a and 3000 a respectively.
基金financial support of National Natural Science Foundation of China(72174196 and 71874193)the Open Fund of State Key Laboratory of Coal Resources and Safe Mining(SKLCRSM21KFA05)National Program for Support of Top-Notch Young Professionals.
文摘The promotion of deep decarbonization in the cement industry is crucial for mitigating global climate change,a key component of which is carbon capture,utilization,and storage(CCUS)technology.Despite its importance,there is a lack of empirical assessments of early opportunities for CCUS implementation in the cement sector.In this study,a comprehensive onshore and offshore source–sink matching optimization assessment framework for CCUS retrofitting in the cement industry,called the SSM-Cement framework,is proposed.The framework comprises four main modules:the cement plant suitability screening module,the storage site assessment module,the source–sink matching optimization model module,and the economic assessment module.By applying this framework to China,919 candidates are initially screened from 1132 existing cement plants.Further,603 CCUS-ready cement plants are identified,and are found to achieve a cumulative emission reduction of 18.5 Gt CO_(2) from 2030 to 2060 by meeting the CCUS feasibility conditions for constructing both onshore and offshore CO_(2) transportation routes.The levelized cost of cement(LCOC)is found to range from 30 to 96(mean 73)USD·(t cement)^(-1),while the levelized carbon avoidance cost(LCAC)ranges from^(-5) to 140(mean 88)USD·(t CO_(2))^(-1).The northeastern and northwestern regions of China are considered priority areas for CCUS implementation,with the LCAC concentrated in the range of 35 to 70 USD·(t CO_(2))^(-1).In addition to onshore storage of 15.8 Gt CO_(2) from 2030 to 2060,offshore storage would contribute 2.7 Gt of decarbonization for coastal cement plants,with comparable LCACs around 90 USD·(t CO_(2))^(-1).
基金supported by the National Key R&D Program of China(Grant No.2022YFC3005401)the National Natural Science Foundation of China(Grant No.52239009)。
文摘Accurate prediction of water level changes in reservoirs is crucial for optimizing the operation of reservoir projects and ensuring their safety.This study proposed a method for reservoir water level prediction based on CEEMDAN-FE and RUN-SVM-RBFNN algorithms.By integrating the adaptive complete ensemble empirical mode decomposition with adaptive noise(CEEMDAN)method and fuzzy entropy(FE)with the new and highly efficient Runge–Kuta optimizer(RUN),adaptive parameter optimization for the support vector machine(SVM)and radial basis function neural network(RBFNN)algorithms was achieved.Regression prediction was conducted on the two reconstructed sequences using SVM and RBFNN according to their respective features.This approach improved the accuracy and stability of predictions.In terms of accuracy,the combined model outperformed single models,with the determination coefficient,root mean square error,and mean absolute error values of 0.9975,0.2418 m,and 0.1616 m,respectively.In terms of stability,the model predicted more consistently in training and testing periods,with stable overall prediction accuracy and a better adaptive ability to complex datasets.The case study demonstrated that the combined prediction model effectively addressed the environmental factors affecting reservoir water levels,leveraged the strength of each predictive method,compensated for their limitations,and clarified the impacts of environmental factors on reservoir water levels.
基金supported by National Key Research and Development Program of China(Grant Nos.2022YFF0800903 and 2024YFC2909905)the National Natural Science Foundation of China(NSFC)(Grant Nos.42261144669,42262026,and 42273073).
文摘Metallogenic research on structural levels can reveal vertical patterns of mineralization and facilitate the deep exploration of economic minerals.However,research focusing on the correlation between structural levels and mineralization remains limited.In this study,we summarize the deformation patterns and associated mineral deposits observed at different crustal levels(i.e.,surface,shallow,middle,and deep structural levels,corresponding to depths of<2,2-8,8-15,and>15 km,respectively).Furthermore,we examine the genetic association between structural levels and metallogenesis,demonstrating that distinct structural levels are linked to specific types of mineralization.Key factors that vary across crustal levels include temperature,pressure,and fluid circulation.Ore-forming processes involve interactions between structures and fluids under varying temperatures and pressures.Structural levels influence mineralization by controlling the temperatures,pressures,and deformation mechanisms that drive the activation,migration,and enrichment of ore-forming materials.
基金The Joint Research Project for Yangtze River Conservation,No.2022-LHYJ-02-0504-05-08Anhui Provincial Scientific Research Project for Universities,China No.2023AH050508。
文摘To explore water level variations and their dynamic influence on the water quality of Huayang Lakes,the water level from 1967 to 2023 and water quality from 2015 to 2023 were analyzed using the Mann–Kendall trend test,box plots,and violin plots.The results show a notable hydrological rhythm of water level alternation between dry and flood seasons in Huayang Lakes,with an average water level of 12.82 m and a monthly range of 11.21–17.24m.Since 2017,the water level of Huayang Rivers has shown a decreasing trend of–0.02 m/a.Total phosphorus(TP)has become the primary pollutant.The TP concentrations in Longgan Lake(the largest lake)during the dry,rising,flood,and retreating seasons from 2015 to 2023were 0.083,0.061,0.050,and 0.059 mg/L,respectively.The effect of water level on TP was mainly observed during the low-water period.When the water level in the dry season rose to 12.25 and 13.00 m,the percentage of TP exceeding 0.1 mg/L in Longgan Lake decreased to 55.8%and 33.3%,respectively.During the dry season,wind and wave disturbances caused the release of endogenous phosphorus in Huayang Lakes.This led to drastic fluctuations in TP concentration,reducing the correlation between water level and TP.When external control is limited,the water level during the dry season should be maintained between 12.25 and 13.0 m.Additionally,it is necessary to accelerate the restoration of submerged macrophyte species(such as Hydrilla verticillata and Vallisneria natans)in the Huayang Rivers.
基金supported by the Beijing Natural Science Foundation(Grant No.L223013)。
文摘For the diagnostics and health management of lithium-ion batteries,numerous models have been developed to understand their degradation characteristics.These models typically fall into two categories:data-driven models and physical models,each offering unique advantages but also facing limitations.Physics-informed neural networks(PINNs)provide a robust framework to integrate data-driven models with physical principles,ensuring consistency with underlying physics while enabling generalization across diverse operational conditions.This study introduces a PINN-based approach to reconstruct open circuit voltage(OCV)curves and estimate key ageing parameters at both the cell and electrode levels.These parameters include available capacity,electrode capacities,and lithium inventory capacity.The proposed method integrates OCV reconstruction models as functional components into convolutional neural networks(CNNs)and is validated using a public dataset.The results reveal that the estimated ageing parameters closely align with those obtained through offline OCV tests,with errors in reconstructed OCV curves remaining within 15 mV.This demonstrates the ability of the method to deliver fast and accurate degradation diagnostics at the electrode level,advancing the potential for precise and efficient battery health management.
