In the most recently published research article in Nature,1 it has been demonstrated for the first time that the TET2 regulates the chromatin structure and leukaemogenesis in stem cells and leukaemia cells via MBD6(bi...In the most recently published research article in Nature,1 it has been demonstrated for the first time that the TET2 regulates the chromatin structure and leukaemogenesis in stem cells and leukaemia cells via MBD6(binds 5-methycytosine residues in RNA)and NSUN2(a RNA methylase).This important finding might pave the way for the development of highly specific novel therapeutic approaches for TET2-mutated cancers.Acute leukaemias represent a biologically complex,molecularly and clinically hetero-geneous group of haematologic malignancies which are characterized by multiple somatically acquired mutations that affect genes of different functional categories.展开更多
文摘In the most recently published research article in Nature,1 it has been demonstrated for the first time that the TET2 regulates the chromatin structure and leukaemogenesis in stem cells and leukaemia cells via MBD6(binds 5-methycytosine residues in RNA)and NSUN2(a RNA methylase).This important finding might pave the way for the development of highly specific novel therapeutic approaches for TET2-mutated cancers.Acute leukaemias represent a biologically complex,molecularly and clinically hetero-geneous group of haematologic malignancies which are characterized by multiple somatically acquired mutations that affect genes of different functional categories.
