Pathological effects of asbestos are probably dependent on the special surface properties of the fibers, such as surface charge, surface metal ions. The present study was designed to determine whether the pretreatment...Pathological effects of asbestos are probably dependent on the special surface properties of the fibers, such as surface charge, surface metal ions. The present study was designed to determine whether the pretreatment of chrysotile asbestos fibers (CAF) with rare earth compounds (REC) solution can reduce their pathogenicity. The results showed that REC-pretreated CAF induced less nitrogen oxide (NO) production by alveolar macrophages (AM). In addition, the pretreatment lowered the capacity of hemolysis and the methylene blue (MB) adsorption of the native CAF. These findings suggested that the pretreatment of CAF with REC solution reduced the in vitro toxicity of CAF by lessening its surface charges. Nevertheless, the pathogenicity and the carcinogenicity of REC-pretreated CAF in vivo remain to be investigated.展开更多
BACKGROUND Diabetes mellitus(DM)is a global health concern,characterized by insulin resistance andβ-cell dysfunction.Traditional treatments often fail to address underlying mechanisms,necessitating alternative therap...BACKGROUND Diabetes mellitus(DM)is a global health concern,characterized by insulin resistance andβ-cell dysfunction.Traditional treatments often fail to address underlying mechanisms,necessitating alternative therapies.Mesenchymal stem cell(MSC)-based therapies have shown promise due to their regenerative and immunomodulatory properties.However,evidence on their efficacy and safety in type 2 DM remains limited and further evaluation is needed.AIM To evaluate the safety,efficacy and therapeutic potential of MSC-based therapies in type 2 DM.METHODS This systematic review analyzed studies published between 2000 and 2025,focusing on autologous and allogeneic MSC therapies in DM.Studies were identified from various databases,including clinical and preclinical trials.Outcomes related to glycemic control,insulin requirements,β-cell function,and safety were assessed.RESULTS MSC-based therapies significantly improved glycemic control,reduced insulin requirements and enhancedβ-cell function in both clinical and preclinical settings.Safety profiles were favorable,with minimal adverse effects observed,primarily transient and self-limiting.No fatal events were reported.Variability in treatment outcomes and the need for standardized protocols were challenges.CONCLUSION MSC-based therapies offer a promising alternative to conventional DM treatments,significantly improving glycemic control and safety.Further research is needed to refine protocols and confirm long-term efficacy.展开更多
文摘Pathological effects of asbestos are probably dependent on the special surface properties of the fibers, such as surface charge, surface metal ions. The present study was designed to determine whether the pretreatment of chrysotile asbestos fibers (CAF) with rare earth compounds (REC) solution can reduce their pathogenicity. The results showed that REC-pretreated CAF induced less nitrogen oxide (NO) production by alveolar macrophages (AM). In addition, the pretreatment lowered the capacity of hemolysis and the methylene blue (MB) adsorption of the native CAF. These findings suggested that the pretreatment of CAF with REC solution reduced the in vitro toxicity of CAF by lessening its surface charges. Nevertheless, the pathogenicity and the carcinogenicity of REC-pretreated CAF in vivo remain to be investigated.
基金Supported by Clinical Variants of Metabolic Syndrome and Hormonal Mechanisms of its Formation in the Residents of Aktobe City,No.8/5-1-04/1-36/1.
文摘BACKGROUND Diabetes mellitus(DM)is a global health concern,characterized by insulin resistance andβ-cell dysfunction.Traditional treatments often fail to address underlying mechanisms,necessitating alternative therapies.Mesenchymal stem cell(MSC)-based therapies have shown promise due to their regenerative and immunomodulatory properties.However,evidence on their efficacy and safety in type 2 DM remains limited and further evaluation is needed.AIM To evaluate the safety,efficacy and therapeutic potential of MSC-based therapies in type 2 DM.METHODS This systematic review analyzed studies published between 2000 and 2025,focusing on autologous and allogeneic MSC therapies in DM.Studies were identified from various databases,including clinical and preclinical trials.Outcomes related to glycemic control,insulin requirements,β-cell function,and safety were assessed.RESULTS MSC-based therapies significantly improved glycemic control,reduced insulin requirements and enhancedβ-cell function in both clinical and preclinical settings.Safety profiles were favorable,with minimal adverse effects observed,primarily transient and self-limiting.No fatal events were reported.Variability in treatment outcomes and the need for standardized protocols were challenges.CONCLUSION MSC-based therapies offer a promising alternative to conventional DM treatments,significantly improving glycemic control and safety.Further research is needed to refine protocols and confirm long-term efficacy.
