Despite its potential as a metal-free tanning agent capable of eliminating Cr pollution in the leather industry,the conventional preparation of poly(carbamoyl sulfonate)faces challenges,such as the extensive use of lo...Despite its potential as a metal-free tanning agent capable of eliminating Cr pollution in the leather industry,the conventional preparation of poly(carbamoyl sulfonate)faces challenges,such as the extensive use of low-boiling organic solvents and low blocking ratios of-NCO groups.Herein,a liquid sulfonate chain extender,2,3-dihydroxypropanesulfonic acid triethylamine salt(DHPSTEA),was initially synthesized.A series of poly(carbamoyl sulfonate)tanning agents(CTAS)were then synthesized using DHPSTEA and various diisocyanates as reaction monomers,with sodium bisulfite serving as the blocking agent and without utilizing organic solvents.CTAS demonstrated a blocking ratio of>99%and satisfactory stability under acidic conditions at room temperature.Application experiments revealed that CTAS exhibited excellent tanning performance,with the parent diisocyanate monomer markedly influencing their tanning properties.CTAS synthesized with dicyclohexylmethane-4,4′-diisocyanate resulted in optimal product performance,yielding a shrinkage temperature of 83.2℃at a 6%dosage.CTAS-tanned leather displayed excellent collagen fiber dispersion,yellowing resistance and mechanical properties.Additionally,CTAS is easy to biodegrade(BOD5/COD>0.45).Thus,this novel metalfree tanning agent holds a great potential as a sustainable alternative to traditional chrome tanning agent.展开更多
The production of leather from animal skins and hides through tanning processes began in the pre-historic ages.Despite the origination of new leather making techniques such as chrome tanning which is being employed ex...The production of leather from animal skins and hides through tanning processes began in the pre-historic ages.Despite the origination of new leather making techniques such as chrome tanning which is being employed extensively today,the traditional method of leather production primarily through vegetable tanning is still being practised mostly in artisanal tanneries in developing nations including Ghana.Artisanal leather making,thus,contributes beneficially to rural livelihood.Nevertheless,the growth of this sector has been stifled by the lack of innovative technologies to enhance productivity.This challenge could be partly linked to the knowledge gap on the scientific principles governing artisanal leather production processes.This study,therefore,elaborates on various process steps and materials employed in traditional leather making in Ghana and the scientific principles underlying each of the processes.It also makes a comparison between traditional and modern leather manufacturing processes and identifies knowledge and technological gaps which would inspire in-depth scientific research into artisanal leather making.展开更多
Collagen,the main component of mammal skin,has been traditionally used in leather manufacturing for thousands of years due to its diverse physicochemical properties.Collagen is the most abundant protein in mammals and...Collagen,the main component of mammal skin,has been traditionally used in leather manufacturing for thousands of years due to its diverse physicochemical properties.Collagen is the most abundant protein in mammals and the main component of the extracellular matrix(ECM).The properties of collagen also make it an ideal building block for the engineering of materials for a range of biomedical applications.Reproductive medicine,especially human fertility preservation strategies and reproductive organ regeneration,has attracted significant attention in recent years as it is key in resolving the growing social concern over aging populations worldwide.Collagen-based biomaterials such as collagen hydrogels,decellularized ECM(dECM),and bioengineering techniques including collagen-based 3D bio-printing have facilitated the engineering of reproductive tissues.This review summarizes the recent progress in apply-ing collagen-based biomaterials in reproductive.Furthermore,we discuss the prospects of collagen-based materials for engineering artificial reproductive tissues,hormone replacement therapy,and reproductive organ reconstruction,aiming to inspire new thoughts and advancements in engineered reproductive tissues research.展开更多
The oral and craniofacial region consists of various types of hard and soft tissues with the intricate organization.With the high prevalence of tissue defects in this specific region,it is highly desirable to enhance ...The oral and craniofacial region consists of various types of hard and soft tissues with the intricate organization.With the high prevalence of tissue defects in this specific region,it is highly desirable to enhance tissue regeneration through the development and use of engineered biomaterials.Collagen,the major component of tissue extracellular matrix,has come into the limelight in regenerative medicine.Although collagen has been widely used as an essential component in biomaterial engineering owing to its low immunogenicity,high biocompatibility,and convenient extraction procedures,there is a limited number of reviews on this specific clinic sector.The need for mechanical enhancement and functional engineering drives intensive efforts in collagen-based biomaterials concentrating on therapeutical outcomes and clinical translation in oral and craniofacial tissue regeneration.Herein,we highlighted the status quo of the design and applications of collagen-based biomaterials in oral and craniofacial tissue reconstruction.The discussion expanded on the inspiration from the leather tanning process on modifications of collagen-based biomaterials and the prospects of multi-tissue reconstruction in this particular dynamic microenvironment.The existing findings will lay a new foundation for the optimization of current collagen-based biomaterials for rebuilding oral and craniofacial tissues in the future.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.22078165)Major Projects of Tackling Key Industrial of Shandong’s New-Traditional Kinetic Energy Conversion.
文摘Despite its potential as a metal-free tanning agent capable of eliminating Cr pollution in the leather industry,the conventional preparation of poly(carbamoyl sulfonate)faces challenges,such as the extensive use of low-boiling organic solvents and low blocking ratios of-NCO groups.Herein,a liquid sulfonate chain extender,2,3-dihydroxypropanesulfonic acid triethylamine salt(DHPSTEA),was initially synthesized.A series of poly(carbamoyl sulfonate)tanning agents(CTAS)were then synthesized using DHPSTEA and various diisocyanates as reaction monomers,with sodium bisulfite serving as the blocking agent and without utilizing organic solvents.CTAS demonstrated a blocking ratio of>99%and satisfactory stability under acidic conditions at room temperature.Application experiments revealed that CTAS exhibited excellent tanning performance,with the parent diisocyanate monomer markedly influencing their tanning properties.CTAS synthesized with dicyclohexylmethane-4,4′-diisocyanate resulted in optimal product performance,yielding a shrinkage temperature of 83.2℃at a 6%dosage.CTAS-tanned leather displayed excellent collagen fiber dispersion,yellowing resistance and mechanical properties.Additionally,CTAS is easy to biodegrade(BOD5/COD>0.45).Thus,this novel metalfree tanning agent holds a great potential as a sustainable alternative to traditional chrome tanning agent.
基金funded by the World Bank,Ghana Government,RWESCK and KNUST.
文摘The production of leather from animal skins and hides through tanning processes began in the pre-historic ages.Despite the origination of new leather making techniques such as chrome tanning which is being employed extensively today,the traditional method of leather production primarily through vegetable tanning is still being practised mostly in artisanal tanneries in developing nations including Ghana.Artisanal leather making,thus,contributes beneficially to rural livelihood.Nevertheless,the growth of this sector has been stifled by the lack of innovative technologies to enhance productivity.This challenge could be partly linked to the knowledge gap on the scientific principles governing artisanal leather production processes.This study,therefore,elaborates on various process steps and materials employed in traditional leather making in Ghana and the scientific principles underlying each of the processes.It also makes a comparison between traditional and modern leather manufacturing processes and identifies knowledge and technological gaps which would inspire in-depth scientific research into artisanal leather making.
基金the Sichuan Science and Technology Program(L.Q.,Grant No.2020YFS0127)the Y.Z.laboratory was financially supported by the Research project of Science&Technology Department of Sichuan Province(Y.Z.,Grant No.2021YJ0416)+3 种基金project of Chengdu Science and Technology Bureau,(Y.Z.,Grant No.2021-YF05-02110-SN)National Natural Science Foundation of China(Y.Z.,Grant No.82001496)China Postdoctoral Science Foundation(Y.Z.,Grant No.2020M680149,2020T130087ZX)the National Global Talents Recruitment Program(J.G.),National Natural Science Foundation of China(22178233)Talents Program of Sichuan Province,Double First Class University Plan of Sichuan University,State Key Laboratory of Polymer Materials Engineering(J.G.,Grant No.sklpme 2020-3-01).
文摘Collagen,the main component of mammal skin,has been traditionally used in leather manufacturing for thousands of years due to its diverse physicochemical properties.Collagen is the most abundant protein in mammals and the main component of the extracellular matrix(ECM).The properties of collagen also make it an ideal building block for the engineering of materials for a range of biomedical applications.Reproductive medicine,especially human fertility preservation strategies and reproductive organ regeneration,has attracted significant attention in recent years as it is key in resolving the growing social concern over aging populations worldwide.Collagen-based biomaterials such as collagen hydrogels,decellularized ECM(dECM),and bioengineering techniques including collagen-based 3D bio-printing have facilitated the engineering of reproductive tissues.This review summarizes the recent progress in apply-ing collagen-based biomaterials in reproductive.Furthermore,we discuss the prospects of collagen-based materials for engineering artificial reproductive tissues,hormone replacement therapy,and reproductive organ reconstruction,aiming to inspire new thoughts and advancements in engineered reproductive tissues research.
基金supported by grants from National Natural Science Foundation of China(Grant No.22178233,32000928,22208228,32271416)Sichuan Science and Technology Program(Grant No.2022ZDZX0031,2023YFS0150)+1 种基金Natural Science Foundation of Sichuan Province(Grant No.2022NSFSC1735,2023NSFSC1097)National Talents Program,Double First Class University Plan of Sichuan University,State Key Laboratory of Polymer Materials Engineering(Grant No.sklpme 2020-03-01).
文摘The oral and craniofacial region consists of various types of hard and soft tissues with the intricate organization.With the high prevalence of tissue defects in this specific region,it is highly desirable to enhance tissue regeneration through the development and use of engineered biomaterials.Collagen,the major component of tissue extracellular matrix,has come into the limelight in regenerative medicine.Although collagen has been widely used as an essential component in biomaterial engineering owing to its low immunogenicity,high biocompatibility,and convenient extraction procedures,there is a limited number of reviews on this specific clinic sector.The need for mechanical enhancement and functional engineering drives intensive efforts in collagen-based biomaterials concentrating on therapeutical outcomes and clinical translation in oral and craniofacial tissue regeneration.Herein,we highlighted the status quo of the design and applications of collagen-based biomaterials in oral and craniofacial tissue reconstruction.The discussion expanded on the inspiration from the leather tanning process on modifications of collagen-based biomaterials and the prospects of multi-tissue reconstruction in this particular dynamic microenvironment.The existing findings will lay a new foundation for the optimization of current collagen-based biomaterials for rebuilding oral and craniofacial tissues in the future.
