Federated Learning(FL)has become a leading decentralized solution that enables multiple clients to train a model in a collaborative environment without directly sharing raw data,making it suitable for privacy-sensitiv...Federated Learning(FL)has become a leading decentralized solution that enables multiple clients to train a model in a collaborative environment without directly sharing raw data,making it suitable for privacy-sensitive applications such as healthcare,finance,and smart systems.As the field continues to evolve,the research field has become more complex and scattered,covering different system designs,training methods,and privacy techniques.This survey is organized around the three core challenges:how the data is distributed,how models are synchronized,and how to defend against attacks.It provides a structured and up-to-date review of FL research from 2023 to 2025,offering a unified taxonomy that categorizes works by data distribution(Horizontal FL,Vertical FL,Federated Transfer Learning,and Personalized FL),training synchronization(synchronous and asynchronous FL),optimization strategies,and threat models(data leakage and poisoning attacks).In particular,we summarize the latest contributions in Vertical FL frameworks for secure multi-party learning,communication-efficient Horizontal FL,and domain-adaptive Federated Transfer Learning.Furthermore,we examine synchronization techniques addressing system heterogeneity,including straggler mitigation in synchronous FL and staleness management in asynchronous FL.The survey covers security threats in FL,such as gradient inversion,membership inference,and poisoning attacks,as well as their defense strategies that include privacy-preserving aggregation and anomaly detection.The paper concludes by outlining unresolved issues and highlighting challenges in handling personalized models,scalability,and real-world adoption.展开更多
We discuss recent progress in using machine-learning(ML)-enabled inverse design techniques applied to photonic devices and components.Specifically,we highlight the design of optical sources,including fiber and semicon...We discuss recent progress in using machine-learning(ML)-enabled inverse design techniques applied to photonic devices and components.Specifically,we highlight the design of optical sources,including fiber and semiconductor lasers,as well as Raman and semiconductor optical amplifiers.Although inverse design approaches for optical detectors remain relatively underexplored,we examine optical layers,particularly metamaterial absorbers,as promising candidates for high-performance optical detection.In addition,we underscore advancements in inverse designing passive optical components,including beam splitters,gratings,and optical fibers.These optical blocks are fundamental in developing next-generation standalone optical communication systems and optical sensing networks,including integrated sensing and communication technologies.While categorizing various reported deep learning architectures across five paradigms,we offer a paradigm-based perspective that reveals how different ML techniques function within modern inverse design methods and enable fast,data-driven solutions that significantly reduce design time and computational demands compared with traditional optimization methods.展开更多
This paper advances new directions for cyber security using adversarial learning and conformal prediction in order to enhance network and computing services defenses against adaptive, malicious, persistent, and tactic...This paper advances new directions for cyber security using adversarial learning and conformal prediction in order to enhance network and computing services defenses against adaptive, malicious, persistent, and tactical offensive threats. Conformal prediction is the principled and unified adaptive and learning framework used to design, develop, and deploy a multi-faceted?self-managing defensive shield to detect, disrupt, and deny intrusive attacks, hostile and malicious behavior, and subterfuge. Conformal prediction leverages apparent relationships between immunity and intrusion detection using non-conformity measures characteristic of affinity, a typicality, and surprise, to recognize patterns and messages as friend or foe and to respond to them accordingly. The solutions proffered throughout are built around active learning, meta-reasoning, randomness, distributed semantics and stratification, and most important and above all around adaptive Oracles. The motivation for using conformal prediction and its immediate off-spring, those of semi-supervised learning and transduction, comes from them first and foremost supporting discriminative and non-parametric methods characteristic of principled demarcation using cohorts and sensitivity analysis to hedge on the prediction outcomes including negative selection, on one side, and providing credibility and confidence indices that assist meta-reasoning and information fusion.展开更多
Artificial Intelligence(AI)is changing healthcare by helping with diagnosis.However,for doctors to trust AI tools,they need to be both accurate and easy to understand.In this study,we created a new machine learning sy...Artificial Intelligence(AI)is changing healthcare by helping with diagnosis.However,for doctors to trust AI tools,they need to be both accurate and easy to understand.In this study,we created a new machine learning system for the early detection of Autism Spectrum Disorder(ASD)in children.Our main goal was to build a model that is not only good at predicting ASD but also clear in its reasoning.For this,we combined several different models,including Random Forest,XGBoost,and Neural Networks,into a single,more powerful framework.We used two different types of datasets:(i)a standard behavioral dataset and(ii)a more complex multimodal dataset with images,audio,and physiological information.The datasets were carefully preprocessed for missing values,redundant features,and dataset imbalance to ensure fair learning.The results outperformed the state-of-the-art with a Regularized Neural Network,achieving 97.6%accuracy on behavioral data.Whereas,on the multimodal data,the accuracy is 98.2%.Other models also did well with accuracies consistently above 96%.We also used SHAP and LIME on a behavioral dataset for models’explainability.展开更多
Distribution transformers play a vital role in power distribution systems,and their reliable operation is crucial for grid stability.This study presents a simulation-based framework for active fault diagnosis and earl...Distribution transformers play a vital role in power distribution systems,and their reliable operation is crucial for grid stability.This study presents a simulation-based framework for active fault diagnosis and early warning of distribution transformers,integrating Sample Ensemble Learning(SEL)with a Self-Optimizing Support Vector Machine(SO-SVM).The SEL technique enhances data diversity and mitigates class imbalance,while SO-SVM adaptively tunes its hyperparameters to improve classification accuracy.A comprehensive transformer model was developed in MATLAB/Simulink to simulate diverse fault scenarios,including inter-turn winding faults,core saturation,and thermal aging.Feature vectors were extracted from voltage,current,and temperature measurements to train and validate the proposed hybrid model.Quantitative analysis shows that the SEL–SO-SVM framework achieves a classification accuracy of 97.8%,a precision of 96.5%,and an F1-score of 97.2%.Beyond classification,the model effectively identified incipient faults,providing an early warning lead time of up to 2.5 s before significant deviations in operational parameters.This predictive capability underscores its potential for preventing catastrophic transformer failures and enabling timely maintenance actions.The proposed approach demonstrates strong applicability for enhancing the reliability and operational safety of distribution transformers in simulated environments,offering a promising foundation for future real-time and field-level implementations.展开更多
This study developed a modeling methodology for statistical optimization-based geologic hazard susceptibility assessment,aiming to enhance the comprehensive performance and classification accuracy of the assessment mo...This study developed a modeling methodology for statistical optimization-based geologic hazard susceptibility assessment,aiming to enhance the comprehensive performance and classification accuracy of the assessment models.First,the cumulative probability method revealed that a low probability(15%)of geologic hazards between any two geologic hazard points occurred outside a buffer zone with a radius of 2297 m(i.e.,the distance threshold).The training dataset was established,consisting of negative samples(non-hazard points)randomly generated based on the distance threshold,positive samples(i.e.,historical hazards),and 13 conditioning factors.Then,models were built using five machine learning algorithms,namely random forest(RF),gradient boosting decision tree(GBDT),naive Bayes(NB),logistic regression(LR),and support vector machine(SVM).The comprehensive performance of the models was assessed using the area under the receiver operating characteristic curve(AUC)and overall accuracy(OA)as indicators,revealing that RF exhibited the best performance,with OA and AUC values of 2.7127 and 0.981,respectively.Furthermore,the machine learning models constructed by considering the distance threshold outperformed those built using the unoptimized dataset.The characteristic factors were ranked using the mutual information method,with their scores decreasing in the order of rainfall(0.1616),altitude(0.06),normalized difference vegetation index(NDVI;0.04),and distance from roads(0.03).Finally,the geologic hazard susceptibility classification was assessed using the natural breaks method combined with a clustering algorithm.The results indicate that the clustering algorithm exhibited higher classification accuracy than the natural breaks method.The findings of this study demonstrate that the proposed model optimization scheme can provide a scientific basis for the prevention and control of geologic hazards.展开更多
Intrusion detection in Internet of Things(IoT)environments presents challenges due to heterogeneous devices,diverse attack vectors,and highly imbalanced datasets.Existing research on the ToN-IoT dataset has largely em...Intrusion detection in Internet of Things(IoT)environments presents challenges due to heterogeneous devices,diverse attack vectors,and highly imbalanced datasets.Existing research on the ToN-IoT dataset has largely emphasized binary classification and single-model pipelines,which often showstrong performance but limited generalizability,probabilistic reliability,and operational interpretability.This study proposes a stacked ensemble deep learning framework that integrates random forest,extreme gradient boosting,and a deep neural network as base learners,with CatBoost as the meta-learner.On the ToN-IoT Linux process dataset,the model achieved near-perfect discrimination(macro area under the curve=0.998),robust calibration,and superior F1-scores compared with standalone classifiers.Interpretability was achieved through SHapley Additive exPlanations–based feature attribution,which highlights actionable drivers ofmalicious behavior,such as command-line patterns,process scheduling anomalies,and CPU usage spikes,and aligns these indicators with MITRE ATT&CK tactics and techniques.Complementary analyses,including cumulative lift and sensitivity-specificity trade-offs,revealed the framework’s suitability for deployment in security operations centers,where calibrated risk scores,transparent explanations,and resource-aware triage are essential.These contributions bridge methodological rigor in artificial intelligence/machine learning with operational priorities in cybersecurity,delivering a scalable and explainable intrusion detection system suitable for real-world deployment in IoT environments.展开更多
Transthyretin (TTR), a carrier protein present in the liver and choroid plexus of the brain, has been shown to be responsible for binding thyroid hormone thyroxin (T4) and retinol in plasma and cerebrospinal fluid (CS...Transthyretin (TTR), a carrier protein present in the liver and choroid plexus of the brain, has been shown to be responsible for binding thyroid hormone thyroxin (T4) and retinol in plasma and cerebrospinal fluid (CSF). TTR aids in sequestering of beta-amyloid peptides Aβ deposition, and protects the brain from trauma, ischemic stroke and Alzheimer disease (AD). Accordingly, hippocampal gene expression of TTR plays a significant role in learning and memory as well as in simulation of spatial memory tasks. TTR via interacting with transcription factor CREB regulates this process and decreased expression leads to memory deficits. By different signaling pathways, like MAPK, AKT, and ERK via Src, TTR provides tropical support through megalin receptor by promoting neurite outgrowth and protecting the neurons from traumatic brain injury. TTR is also responsible for the transient rise in intracellular Ca2+ via NMDA receptor, playing a dominant role under excitotoxic conditions. In this review, we tried to shed light on how TTR is involved in maintaining normal cognitive processes, its role in learning and memory, under memory deficit conditions;by which mechanisms it promotes neurite outgrowth;and how it protects the brain from Alzheimer disease (AD).展开更多
Predicting the behavior of renewable energy systems requires models capable of generating accurate forecasts from limited historical data,a challenge that becomes especially pronounced when commissioning new facil-iti...Predicting the behavior of renewable energy systems requires models capable of generating accurate forecasts from limited historical data,a challenge that becomes especially pronounced when commissioning new facil-ities where operational records are scarce.This review aims to synthesize recent progress in data-efficient deep learning approaches for addressing such“cold-start”forecasting problems.It primarily covers three interrelated domains—solar photovoltaic(PV),wind power,and electrical load forecasting—where data scarcity and operational variability are most critical,while also including representative studies on hydropower and carbon emission prediction to provide a broader systems perspective.To this end,we examined trends from over 150 predominantly peer-reviewed studies published between 2019 and mid-2025,highlighting advances in zero-shot and few-shot meta-learning frameworks that enable rapid model adaptation with minimal labeled data.Moreover,transfer learning approaches combined with spatiotemporal graph neural networks have been employed to transfer knowledge from existing energy assets to new,data-sparse environments,effectively capturing hidden dependencies among geographic features,meteorological dynamics,and grid structures.Synthetic data generation has further proven valuable for expanding training samples and mitigating overfitting in cold-start scenarios.In addition,large language models and explainable artificial intelligence(XAI)—notably conversational XAI systems—have been used to interpret and communicate complex model behaviors in accessible terms,fostering operator trust from the earliest deployment stages.By consolidating methodological advances,unresolved challenges,and open-source resources,this review provides a coherent overview of deep learning strategies that can shorten the data-sparse ramp-up period of new energy infrastructures and accelerate the transition toward resilient,low-carbon electricity grids.展开更多
Colorectal cancer is the third most diagnosed cancer worldwide,and immune checkpoint inhibitors have shown promising therapeutic outcomes in selected patient groups.This study performed a comprehensive analysis of mul...Colorectal cancer is the third most diagnosed cancer worldwide,and immune checkpoint inhibitors have shown promising therapeutic outcomes in selected patient groups.This study performed a comprehensive analysis of multi-omics data from The Cancer Genome Atlas colorectal adenocarcinoma cohort(TCGA-COADREAD),accessed through cBioPortal,to develop machine learning models for predicting progression-free survival(PFS)following immunotherapy.The dataset included clinical variables,genomic alterations in Kirsten Rat Sarcoma Viral Oncogene Homolog(KRAS),B-Raf Proto-Oncogene(BRAF),and Neuroblastoma RAS Viral Oncogene Homolog(NRAS),microsatellite instability(MSI)status,tumor mutation burden(TMB),and expression of immune checkpoint genes.Kaplan–Meier analysis showed that KRAS mutations were significantly associated with reduced PFS,while BRAF and NRAS mutations had no significant impact.MSI-high tumors exhibited elevated TMB and increased immune checkpoint expression,reflecting their immunologically active phenotype.We developed both survival and classification models,with the Extra Trees classifier achieving the best performance(accuracy=0.86,precision=0.67,recall=0.70,F1-score=0.68,AUC=0.84).These findings highlight the potential of combining genomic and immune biomarkers with machine learning to improve patient stratification and guide personalized immunotherapy decisions.An interactive web application was also developed to enable clinicians to input patient-specific molecular and clinical data and visualize individualized PFS predictions,supporting timely,data-driven treatment planning.展开更多
Modern manufacturing processes have become more reliant on automation because of the accelerated transition from Industry 3.0 to Industry 4.0.Manual inspection of products on assembly lines remains inefficient,prone t...Modern manufacturing processes have become more reliant on automation because of the accelerated transition from Industry 3.0 to Industry 4.0.Manual inspection of products on assembly lines remains inefficient,prone to errors and lacks consistency,emphasizing the need for a reliable and automated inspection system.Leveraging both object detection and image segmentation approaches,this research proposes a vision-based solution for the detection of various kinds of tools in the toolkit using deep learning(DL)models.Two Intel RealSense D455f depth cameras were arranged in a top down configuration to capture both RGB and depth images of the toolkits.After applying multiple constraints and enhancing them through preprocessing and augmentation,a dataset consisting of 3300 annotated RGB-D photos was generated.Several DL models were selected through a comprehensive assessment of mean Average Precision(mAP),precision-recall equilibrium,inference latency(target≥30 FPS),and computational burden,resulting in a preference for YOLO and Region-based Convolutional Neural Networks(R-CNN)variants over ViT-based models due to the latter’s increased latency and resource requirements.YOLOV5,YOLOV8,YOLOV11,Faster R-CNN,and Mask R-CNN were trained on the annotated dataset and evaluated using key performance metrics(Recall,Accuracy,F1-score,and Precision).YOLOV11 demonstrated balanced excellence with 93.0%precision,89.9%recall,and a 90.6%F1-score in object detection,as well as 96.9%precision,95.3%recall,and a 96.5%F1-score in instance segmentation with an average inference time of 25 ms per frame(≈40 FPS),demonstrating real-time performance.Leveraging these results,a YOLOV11-based windows application was successfully deployed in a real-time assembly line environment,where it accurately processed live video streams to detect and segment tools within toolkits,demonstrating its practical effectiveness in industrial automation.The application is capable of precisely measuring socket dimensions by utilising edge detection techniques on YOLOv11 segmentation masks,in addition to detection and segmentation.This makes it possible to do specification-level quality control right on the assembly line,which improves the ability to examine things in real time.The implementation is a big step forward for intelligent manufacturing in the Industry 4.0 paradigm.It provides a scalable,efficient,and accurate way to do automated inspection and dimensional verification activities.展开更多
Ferroptosis,a type of cell death that mainly involves iron metabolism imbalance and lipid peroxidation,is strongly correlated with the phagocytic response caused by bleeding after spinal cord injury.Thus,in this study...Ferroptosis,a type of cell death that mainly involves iron metabolism imbalance and lipid peroxidation,is strongly correlated with the phagocytic response caused by bleeding after spinal cord injury.Thus,in this study,bulk RNA sequencing data(GSE47681 and GSE5296)and single-cell RNA sequencing data(GSE162610)were acquired from gene expression databases.We then conducted differential analysis and immune infiltration analysis.Atf3 and Piezo1 were identified as key ferroptosis genes through random forest and least absolute shrinkage and selection operator algorithms.Further analysis of single-cell RNA sequencing data revealed a close relationship between ferroptosis and cell types such as macrophages/microglia and their intrinsic state transition processes.Differences in transcription factor regulation and intercellular communication networks were found in ferroptosis-related cells,confirming the high expression of Atf3 and Piezo1 in these cells.Molecular docking analysis confirmed that the proteins encoded by these genes can bind cycloheximide.In a mouse model of T8 spinal cord injury,low-dose cycloheximide treatment was found to improve neurological function,decrease levels of the pro-inflammatory cytokine inducible nitric oxide synthase,and increase levels of the anti-inflammatory cytokine arginase 1.Correspondingly,the expression of the ferroptosis-related gene Gpx4 increased in macrophages/microglia,while the expression of Acsl4 decreased.Our findings reveal the important role of ferroptosis in the treatment of spinal cord injury,identify the key cell types and genes involved in ferroptosis after spinal cord injury,and validate the efficacy of potential drug therapies,pointing to new directions in the treatment of spinal cord injury.展开更多
With the efficient and intelligent development of computer-based big data processing,applying machine learning methods to the processing and interpretation of logging data in the field of geophysical well logging has ...With the efficient and intelligent development of computer-based big data processing,applying machine learning methods to the processing and interpretation of logging data in the field of geophysical well logging has broad potential for improving production efficiency.Currently,the Jiyuan Oilfield in the Ordos Basin relies mainly on manual reprocessing and interpretation of old well logging data to identify different fluid types in low-contrast reservoirs,guiding subsequent production work.This study uses well logging data from the Chang 1 reservoir,partitioning the dataset based on individual wells for model training and testing.A deep learning model for intelligent reservoir fluid identification was constructed by incorporating the focal loss function.Comparative validations with five other models,including logistic regression(LR),naive Bayes(NB),gradient boosting decision trees(GBDT),random forest(RF),and support vector machine(SVM),show that this model demonstrates superior identification performance and significantly improves the accuracy of identifying oil-bearing fluids.Mutual information analysis reveals the model's differential dependency on various logging parameters for reservoir fluid identification.This model provides important references and a basis for conducting regional studies and revisiting old wells,demonstrating practical value that can be widely applied.展开更多
The current research was grounded in prior interdisciplinary research that showed cognitive ability (verbal ability for translating cognitions into oral language) and multiple-working memory endophenotypes (behavioral...The current research was grounded in prior interdisciplinary research that showed cognitive ability (verbal ability for translating cognitions into oral language) and multiple-working memory endophenotypes (behavioral markers of genetic or brain bases of language learning) predict reading and writing achievement in students with and without specific learning disabilities in written language (SLDs-WL). Results largely replicated prior findings that verbally gifted with dyslexia score higher on reading and writing achievement than those with average verbal ability but not on endophenotypes. The current study extended that research by comparing those with and without SLDs-WL with assessed verbal ability held constant. The verbally gifted without SLDs-WL (n = 14) scored higher than the verbally gifted with SLDs-WL (n = 27) on six language skills (oral sentence construction, best and fastest handwriting in copying, single real word oral reading accuracy, oral pseudoword reading accuracy and rate) and four endophenotypes (orthographic and morphological coding, orthographic loop, and switching attention). The verbally average without SLDs-WL (n = 6) scored higher than the verbally average with SLDs-WL (n = 22) on four language skills (best and fastest hand-writing in copying, oral pseudoword reading accuracy and rate) and two endophenotypes (orthographic coding and orthographic loop). Implications of results for translating interdisciplinary research into flexible definitions for assessment and instruction to serve students with varying verbal abilities and language learning and endophenotype profiles are discussed along with directions for future research.展开更多
The concept of Network Centric Therapy represents an amalgamation of wearable and wireless inertial sensor systems and machine learning with access to a Cloud computing environment. The advent of Network Centric Thera...The concept of Network Centric Therapy represents an amalgamation of wearable and wireless inertial sensor systems and machine learning with access to a Cloud computing environment. The advent of Network Centric Therapy is highly relevant to the treatment of Parkinson’s disease through deep brain stimulation. Originally wearable and wireless systems for quantifying Parkinson’s disease involved the use a smartphone to quantify hand tremor. Although originally novel, the smartphone has notable issues as a wearable application for quantifying movement disorder tremor. The smartphone has evolved in a pathway that has made the smartphone progressively more cumbersome to mount about the dorsum of the hand. Furthermore, the smartphone utilizes an inertial sensor package that is not certified for medical analysis, and the trial data access a provisional Cloud computing environment through an email account. These concerns are resolved with the recent development of a conformal wearable and wireless inertial sensor system. This conformal wearable and wireless system mounts to the hand with the profile of a bandage by adhesive and accesses a secure Cloud computing environment through a segmented wireless connectivity strategy involving a smartphone and tablet. Additionally, the conformal wearable and wireless system is certified by the FDA of the United States of America for ascertaining medical grade inertial sensor data. These characteristics make the conformal wearable and wireless system uniquely suited for the quantification of Parkinson’s disease treatment through deep brain stimulation. Preliminary evaluation of the conformal wearable and wireless system is demonstrated through the differentiation of deep brain stimulation set to “On” and “Off” status. Based on the robustness of the acceleration signal, this signal was selected to quantify hand tremor for the prescribed deep brain stimulation settings. Machine learning classification using the Waikato Environment for Knowledge Analysis (WEKA) was applied using the multilayer perceptron neural network. The multilayer perceptron neural network achieved considerable classification accuracy for distinguishing between the deep brain stimulation system set to “On” and “Off” status through the quantified acceleration signal data obtained by this recently developed conformal wearable and wireless system. The research achievement establishes a progressive pathway to the future objective of achieving deep brain stimulation capabilities that promote closed-loop acquisition of configuration parameters that are uniquely optimized to the individual through extrinsic means of a highly conformal wearable and wireless inertial sensor system and machine learning with access to Cloud computing resources.展开更多
Using the latest available artificial intelligence (AI) technology, an advanced algorithm LIVERFAStTM has been used to evaluate the diagnostic accuracy of machine learning (ML) biomarker algorithms to assess liver dam...Using the latest available artificial intelligence (AI) technology, an advanced algorithm LIVERFAStTM has been used to evaluate the diagnostic accuracy of machine learning (ML) biomarker algorithms to assess liver damage. Prevalence of NAFLD (Nonalcoholic fatty liver disease) and resulting NASH (nonalcoholic steatohepatitis) are constantly increasing worldwide, creating challenges for screening as the diagnosis for NASH requires invasive liver biopsy. Key issues in NAFLD patients are the differentiation of NASH from simple steatosis and identification of advanced hepatic fibrosis. In this prospective study, the staging of three different lesions of the liver to diagnose fatty liver was analyzed using a proprietary ML algorithm LIVERFAStTM developed with a database of 2862 unique medical assessments of biomarkers, where 1027 assessments were used to train the algorithm and 1835 constituted the validation set. Data of 13,068 patients who underwent the LIVERFAStTM test for evaluation of fatty liver disease were analysed. Data evaluation revealed 11% of the patients exhibited significant fibrosis with fibrosis scores 0.6 - 1.00. Approximately 7% of the population had severe hepatic inflammation. Steatosis was observed in most patients, 63%, whereas severe steatosis S3 was observed in 20%. Using modified SAF (Steatosis, Activity and Fibrosis) scores obtained using the LIVERFAStTM algorithm, NAFLD was detected in 13.41% of the patients (Sx > 0, Ay 0). Approximately 1.91% (Sx > 0, Ay = 2, Fz > 0) of the patients showed NAFLD or NASH scorings while 1.08% had confirmed NASH (Sx > 0, Ay > 2, Fz = 1 - 2) and 1.49% had advanced NASH (Sx > 0, Ay > 2, Fz = 3 - 4). The modified SAF scoring system generated by LIVERFAStTM provides a simple and convenient evaluation of NAFLD and NASH in a cohort of Southeast Asians. This system may lead to the use of noninvasive liver tests in extended populations for more accurate diagnosis of liver pathology, prediction of clinical path of individuals at all stages of liver diseases, and provision of an efficient system for therapeutic interventions.展开更多
Split Learning(SL)has been promoted as a promising collaborative machine learning technique designed to address data privacy and resource efficiency.Specifically,neural networks are divided into client and server subn...Split Learning(SL)has been promoted as a promising collaborative machine learning technique designed to address data privacy and resource efficiency.Specifically,neural networks are divided into client and server subnetworks in order to mitigate the exposure of sensitive data and reduce the overhead on client devices,thereby making SL particularly suitable for resource-constrained devices.Although SL prevents the direct transmission of raw data,it does not alleviate entirely the risk of privacy breaches.In fact,the data intermediately transmitted to the server sub-model may include patterns or information that could reveal sensitive data.Moreover,achieving a balance between model utility and data privacy has emerged as a challenging problem.In this article,we propose a novel defense approach that combines:(i)Adversarial learning,and(ii)Network channel pruning.In particular,the proposed adversarial learning approach is specifically designed to reduce the risk of private data exposure while maintaining high performance for the utility task.On the other hand,the suggested channel pruning enables the model to adaptively adjust and reactivate pruned channels while conducting adversarial training.The integration of these two techniques reduces the informativeness of the intermediate data transmitted by the client sub-model,thereby enhancing its robustness against attribute inference attacks without adding significant computational overhead,making it wellsuited for IoT devices,mobile platforms,and Internet of Vehicles(IoV)scenarios.The proposed defense approach was evaluated using EfficientNet-B0,a widely adopted compact model,along with three benchmark datasets.The obtained results showcased its superior defense capability against attribute inference attacks compared to existing state-of-the-art methods.This research’s findings demonstrated the effectiveness of the proposed channel pruning-based adversarial training approach in achieving the intended compromise between utility and privacy within SL frameworks.In fact,the classification accuracy attained by the attackers witnessed a drastic decrease of 70%.展开更多
Adversarial Reinforcement Learning(ARL)models for intelligent devices and Network Intrusion Detection Systems(NIDS)improve systemresilience against sophisticated cyber-attacks.As a core component of ARL,Adversarial Tr...Adversarial Reinforcement Learning(ARL)models for intelligent devices and Network Intrusion Detection Systems(NIDS)improve systemresilience against sophisticated cyber-attacks.As a core component of ARL,Adversarial Training(AT)enables NIDS agents to discover and prevent newattack paths by exposing them to competing examples,thereby increasing detection accuracy,reducing False Positives(FPs),and enhancing network security.To develop robust decision-making capabilities for real-world network disruptions and hostile activity,NIDS agents are trained in adversarial scenarios to monitor the current state and notify management of any abnormal or malicious activity.The accuracy and timeliness of the IDS were crucial to the network’s availability and reliability at this time.This paper analyzes ARL applications in NIDS,revealing State-of-The-Art(SoTA)methodology,issues,and future research prospects.This includes Reinforcement Machine Learning(RML)-based NIDS,which enables an agent to interact with the environment to achieve a goal,andDeep Reinforcement Learning(DRL)-based NIDS,which can solve complex decision-making problems.Additionally,this survey study addresses cybersecurity adversarial circumstances and their importance for ARL and NIDS.Architectural design,RL algorithms,feature representation,and training methodologies are examined in the ARL-NIDS study.This comprehensive study evaluates ARL for intelligent NIDS research,benefiting cybersecurity researchers,practitioners,and policymakers.The report promotes cybersecurity defense research and innovation.展开更多
Ovarian cancer(OC)is one of the leading causes of death related to gynecological cancer,with the main difficulty of its early diagnosis and a heterogeneous nature of tumor biomarkers.Machine learning(ML)has the potent...Ovarian cancer(OC)is one of the leading causes of death related to gynecological cancer,with the main difficulty of its early diagnosis and a heterogeneous nature of tumor biomarkers.Machine learning(ML)has the potential to process complex datasets and support decision-making in OC diagnosis.Nevertheless,traditional ML models tend to be biased,overfitting,noisy,and less generalized.Moreover,their black-box nature reduces interpretability and limits their practical clinical applicability.In this study,we introduce an explainable ensemble learning(EL)model,TreeX-Stack,based on a stacking architecture that employs tree-based learners such as Decision Tree(DT),Random Forest(RF),Gradient Boosting(GB),and Extreme Gradient Boosting(XGBoost)as base learners,and Logistic Regression(LR)as the meta-learner to enhance ovarian cancer(OC)diagnosis.Local Interpretable ModelAgnostic Explanations(LIME)are used to explain individual predictions,making the model outputs more clinically interpretable and applicable.The model is trained on the dataset that includes demographic information,blood test,general chemistry,and tumor markers.Extensive preprocessing includes handling missing data using iterative imputation with Bayesian Ridge and addressing multicollinearity by removing features with correlation coefficients above 0.7.Relevant features are then selected using the Boruta feature selection method.To obtain robust and unbiased performance estimates during hyperparameter tuning,nested cross-validation(CV)with grid search is employed,and all experiments are repeated five times to ensure statistical reliability.TreeX-Stack demonstrates excellent diagnostic performance,achieving an accuracy of 0.9027,a precision of 0.8673,a recall of 0.9391,and an F1-score of 0.9012.Feature-importance analyses using LIME and permutation importance highlight Human Epididymis Protein 4(HE4)as the most significant biomarker for OC.The combination of high predictive performance and interpretability makes TreeX-Stack a reliable tool for clinical decision support in OC diagnosis.展开更多
The malicious dissemination of hate speech via compromised accounts,automated bot networks and malware-driven social media campaigns has become a growing cybersecurity concern.Automatically detecting such content in S...The malicious dissemination of hate speech via compromised accounts,automated bot networks and malware-driven social media campaigns has become a growing cybersecurity concern.Automatically detecting such content in Spanish is challenging due to linguistic complexity and the scarcity of annotated resources.In this paper,we compare two predominant AI-based approaches for the forensic detection of malicious hate speech:(1)finetuning encoder-only models that have been trained in Spanish and(2)In-Context Learning techniques(Zero-and Few-Shot Learning)with large-scale language models.Our approach goes beyond binary classification,proposing a comprehensive,multidimensional evaluation that labels each text by:(1)type of speech,(2)recipient,(3)level of intensity(ordinal)and(4)targeted group(multi-label).Performance is evaluated using an annotated Spanish corpus,standard metrics such as precision,recall and F1-score and stability-oriented metrics to evaluate the stability of the transition from zero-shot to few-shot prompting(Zero-to-Few Shot Retention and Zero-to-Few Shot Gain)are applied.The results indicate that fine-tuned encoder-only models(notably MarIA and BETO variants)consistently deliver the strongest and most reliable performance:in our experiments their macro F1-scores lie roughly in the range of approximately 46%–66%depending on the task.Zero-shot approaches are much less stable and typically yield substantially lower performance(observed F1-scores range approximately 0%–39%),often producing invalid outputs in practice.Few-shot prompting(e.g.,Qwen 38B,Mistral 7B)generally improves stability and recall relative to pure zero-shot,bringing F1-scores into a moderate range of approximately 20%–51%but still falling short of fully fine-tuned models.These findings highlight the importance of supervised adaptation and discuss the potential of both paradigms as components in AI-powered cybersecurity and malware forensics systems designed to identify and mitigate coordinated online hate campaigns.展开更多
文摘Federated Learning(FL)has become a leading decentralized solution that enables multiple clients to train a model in a collaborative environment without directly sharing raw data,making it suitable for privacy-sensitive applications such as healthcare,finance,and smart systems.As the field continues to evolve,the research field has become more complex and scattered,covering different system designs,training methods,and privacy techniques.This survey is organized around the three core challenges:how the data is distributed,how models are synchronized,and how to defend against attacks.It provides a structured and up-to-date review of FL research from 2023 to 2025,offering a unified taxonomy that categorizes works by data distribution(Horizontal FL,Vertical FL,Federated Transfer Learning,and Personalized FL),training synchronization(synchronous and asynchronous FL),optimization strategies,and threat models(data leakage and poisoning attacks).In particular,we summarize the latest contributions in Vertical FL frameworks for secure multi-party learning,communication-efficient Horizontal FL,and domain-adaptive Federated Transfer Learning.Furthermore,we examine synchronization techniques addressing system heterogeneity,including straggler mitigation in synchronous FL and staleness management in asynchronous FL.The survey covers security threats in FL,such as gradient inversion,membership inference,and poisoning attacks,as well as their defense strategies that include privacy-preserving aggregation and anomaly detection.The paper concludes by outlining unresolved issues and highlighting challenges in handling personalized models,scalability,and real-world adoption.
基金the School of Engineering and Built Environment at Anglia Ruskin University,UK,for the supportthe support of IRC-CSS and the Electrical Engineering Department,KFUPM,Saudi Arabia。
文摘We discuss recent progress in using machine-learning(ML)-enabled inverse design techniques applied to photonic devices and components.Specifically,we highlight the design of optical sources,including fiber and semiconductor lasers,as well as Raman and semiconductor optical amplifiers.Although inverse design approaches for optical detectors remain relatively underexplored,we examine optical layers,particularly metamaterial absorbers,as promising candidates for high-performance optical detection.In addition,we underscore advancements in inverse designing passive optical components,including beam splitters,gratings,and optical fibers.These optical blocks are fundamental in developing next-generation standalone optical communication systems and optical sensing networks,including integrated sensing and communication technologies.While categorizing various reported deep learning architectures across five paradigms,we offer a paradigm-based perspective that reveals how different ML techniques function within modern inverse design methods and enable fast,data-driven solutions that significantly reduce design time and computational demands compared with traditional optimization methods.
文摘This paper advances new directions for cyber security using adversarial learning and conformal prediction in order to enhance network and computing services defenses against adaptive, malicious, persistent, and tactical offensive threats. Conformal prediction is the principled and unified adaptive and learning framework used to design, develop, and deploy a multi-faceted?self-managing defensive shield to detect, disrupt, and deny intrusive attacks, hostile and malicious behavior, and subterfuge. Conformal prediction leverages apparent relationships between immunity and intrusion detection using non-conformity measures characteristic of affinity, a typicality, and surprise, to recognize patterns and messages as friend or foe and to respond to them accordingly. The solutions proffered throughout are built around active learning, meta-reasoning, randomness, distributed semantics and stratification, and most important and above all around adaptive Oracles. The motivation for using conformal prediction and its immediate off-spring, those of semi-supervised learning and transduction, comes from them first and foremost supporting discriminative and non-parametric methods characteristic of principled demarcation using cohorts and sensitivity analysis to hedge on the prediction outcomes including negative selection, on one side, and providing credibility and confidence indices that assist meta-reasoning and information fusion.
基金the King Salman center for Disability Research for funding this work through Research Group No.KSRG-2024-050.
文摘Artificial Intelligence(AI)is changing healthcare by helping with diagnosis.However,for doctors to trust AI tools,they need to be both accurate and easy to understand.In this study,we created a new machine learning system for the early detection of Autism Spectrum Disorder(ASD)in children.Our main goal was to build a model that is not only good at predicting ASD but also clear in its reasoning.For this,we combined several different models,including Random Forest,XGBoost,and Neural Networks,into a single,more powerful framework.We used two different types of datasets:(i)a standard behavioral dataset and(ii)a more complex multimodal dataset with images,audio,and physiological information.The datasets were carefully preprocessed for missing values,redundant features,and dataset imbalance to ensure fair learning.The results outperformed the state-of-the-art with a Regularized Neural Network,achieving 97.6%accuracy on behavioral data.Whereas,on the multimodal data,the accuracy is 98.2%.Other models also did well with accuracies consistently above 96%.We also used SHAP and LIME on a behavioral dataset for models’explainability.
文摘Distribution transformers play a vital role in power distribution systems,and their reliable operation is crucial for grid stability.This study presents a simulation-based framework for active fault diagnosis and early warning of distribution transformers,integrating Sample Ensemble Learning(SEL)with a Self-Optimizing Support Vector Machine(SO-SVM).The SEL technique enhances data diversity and mitigates class imbalance,while SO-SVM adaptively tunes its hyperparameters to improve classification accuracy.A comprehensive transformer model was developed in MATLAB/Simulink to simulate diverse fault scenarios,including inter-turn winding faults,core saturation,and thermal aging.Feature vectors were extracted from voltage,current,and temperature measurements to train and validate the proposed hybrid model.Quantitative analysis shows that the SEL–SO-SVM framework achieves a classification accuracy of 97.8%,a precision of 96.5%,and an F1-score of 97.2%.Beyond classification,the model effectively identified incipient faults,providing an early warning lead time of up to 2.5 s before significant deviations in operational parameters.This predictive capability underscores its potential for preventing catastrophic transformer failures and enabling timely maintenance actions.The proposed approach demonstrates strong applicability for enhancing the reliability and operational safety of distribution transformers in simulated environments,offering a promising foundation for future real-time and field-level implementations.
基金supported by a project entitled Loess Plateau Region-Watershed-Slope Geological Hazard Multi-Scale Collaborative Intelligent Early Warning System of the National Key R&D Program of China(2022YFC3003404)a project of the Shaanxi Youth Science and Technology Star(2021KJXX-87)public welfare geological survey projects of Shaanxi Institute of Geologic Survey(20180301,201918,202103,and 202413)。
文摘This study developed a modeling methodology for statistical optimization-based geologic hazard susceptibility assessment,aiming to enhance the comprehensive performance and classification accuracy of the assessment models.First,the cumulative probability method revealed that a low probability(15%)of geologic hazards between any two geologic hazard points occurred outside a buffer zone with a radius of 2297 m(i.e.,the distance threshold).The training dataset was established,consisting of negative samples(non-hazard points)randomly generated based on the distance threshold,positive samples(i.e.,historical hazards),and 13 conditioning factors.Then,models were built using five machine learning algorithms,namely random forest(RF),gradient boosting decision tree(GBDT),naive Bayes(NB),logistic regression(LR),and support vector machine(SVM).The comprehensive performance of the models was assessed using the area under the receiver operating characteristic curve(AUC)and overall accuracy(OA)as indicators,revealing that RF exhibited the best performance,with OA and AUC values of 2.7127 and 0.981,respectively.Furthermore,the machine learning models constructed by considering the distance threshold outperformed those built using the unoptimized dataset.The characteristic factors were ranked using the mutual information method,with their scores decreasing in the order of rainfall(0.1616),altitude(0.06),normalized difference vegetation index(NDVI;0.04),and distance from roads(0.03).Finally,the geologic hazard susceptibility classification was assessed using the natural breaks method combined with a clustering algorithm.The results indicate that the clustering algorithm exhibited higher classification accuracy than the natural breaks method.The findings of this study demonstrate that the proposed model optimization scheme can provide a scientific basis for the prevention and control of geologic hazards.
文摘Intrusion detection in Internet of Things(IoT)environments presents challenges due to heterogeneous devices,diverse attack vectors,and highly imbalanced datasets.Existing research on the ToN-IoT dataset has largely emphasized binary classification and single-model pipelines,which often showstrong performance but limited generalizability,probabilistic reliability,and operational interpretability.This study proposes a stacked ensemble deep learning framework that integrates random forest,extreme gradient boosting,and a deep neural network as base learners,with CatBoost as the meta-learner.On the ToN-IoT Linux process dataset,the model achieved near-perfect discrimination(macro area under the curve=0.998),robust calibration,and superior F1-scores compared with standalone classifiers.Interpretability was achieved through SHapley Additive exPlanations–based feature attribution,which highlights actionable drivers ofmalicious behavior,such as command-line patterns,process scheduling anomalies,and CPU usage spikes,and aligns these indicators with MITRE ATT&CK tactics and techniques.Complementary analyses,including cumulative lift and sensitivity-specificity trade-offs,revealed the framework’s suitability for deployment in security operations centers,where calibrated risk scores,transparent explanations,and resource-aware triage are essential.These contributions bridge methodological rigor in artificial intelligence/machine learning with operational priorities in cybersecurity,delivering a scalable and explainable intrusion detection system suitable for real-world deployment in IoT environments.
文摘Transthyretin (TTR), a carrier protein present in the liver and choroid plexus of the brain, has been shown to be responsible for binding thyroid hormone thyroxin (T4) and retinol in plasma and cerebrospinal fluid (CSF). TTR aids in sequestering of beta-amyloid peptides Aβ deposition, and protects the brain from trauma, ischemic stroke and Alzheimer disease (AD). Accordingly, hippocampal gene expression of TTR plays a significant role in learning and memory as well as in simulation of spatial memory tasks. TTR via interacting with transcription factor CREB regulates this process and decreased expression leads to memory deficits. By different signaling pathways, like MAPK, AKT, and ERK via Src, TTR provides tropical support through megalin receptor by promoting neurite outgrowth and protecting the neurons from traumatic brain injury. TTR is also responsible for the transient rise in intracellular Ca2+ via NMDA receptor, playing a dominant role under excitotoxic conditions. In this review, we tried to shed light on how TTR is involved in maintaining normal cognitive processes, its role in learning and memory, under memory deficit conditions;by which mechanisms it promotes neurite outgrowth;and how it protects the brain from Alzheimer disease (AD).
文摘Predicting the behavior of renewable energy systems requires models capable of generating accurate forecasts from limited historical data,a challenge that becomes especially pronounced when commissioning new facil-ities where operational records are scarce.This review aims to synthesize recent progress in data-efficient deep learning approaches for addressing such“cold-start”forecasting problems.It primarily covers three interrelated domains—solar photovoltaic(PV),wind power,and electrical load forecasting—where data scarcity and operational variability are most critical,while also including representative studies on hydropower and carbon emission prediction to provide a broader systems perspective.To this end,we examined trends from over 150 predominantly peer-reviewed studies published between 2019 and mid-2025,highlighting advances in zero-shot and few-shot meta-learning frameworks that enable rapid model adaptation with minimal labeled data.Moreover,transfer learning approaches combined with spatiotemporal graph neural networks have been employed to transfer knowledge from existing energy assets to new,data-sparse environments,effectively capturing hidden dependencies among geographic features,meteorological dynamics,and grid structures.Synthetic data generation has further proven valuable for expanding training samples and mitigating overfitting in cold-start scenarios.In addition,large language models and explainable artificial intelligence(XAI)—notably conversational XAI systems—have been used to interpret and communicate complex model behaviors in accessible terms,fostering operator trust from the earliest deployment stages.By consolidating methodological advances,unresolved challenges,and open-source resources,this review provides a coherent overview of deep learning strategies that can shorten the data-sparse ramp-up period of new energy infrastructures and accelerate the transition toward resilient,low-carbon electricity grids.
基金funded by the Research,Development,and Innovation Authority(RDIA)—Kingdom of Saudi Arabia(Grant No.13292-psu-2023-PSNU-R-3-1-EF-).
文摘Colorectal cancer is the third most diagnosed cancer worldwide,and immune checkpoint inhibitors have shown promising therapeutic outcomes in selected patient groups.This study performed a comprehensive analysis of multi-omics data from The Cancer Genome Atlas colorectal adenocarcinoma cohort(TCGA-COADREAD),accessed through cBioPortal,to develop machine learning models for predicting progression-free survival(PFS)following immunotherapy.The dataset included clinical variables,genomic alterations in Kirsten Rat Sarcoma Viral Oncogene Homolog(KRAS),B-Raf Proto-Oncogene(BRAF),and Neuroblastoma RAS Viral Oncogene Homolog(NRAS),microsatellite instability(MSI)status,tumor mutation burden(TMB),and expression of immune checkpoint genes.Kaplan–Meier analysis showed that KRAS mutations were significantly associated with reduced PFS,while BRAF and NRAS mutations had no significant impact.MSI-high tumors exhibited elevated TMB and increased immune checkpoint expression,reflecting their immunologically active phenotype.We developed both survival and classification models,with the Extra Trees classifier achieving the best performance(accuracy=0.86,precision=0.67,recall=0.70,F1-score=0.68,AUC=0.84).These findings highlight the potential of combining genomic and immune biomarkers with machine learning to improve patient stratification and guide personalized immunotherapy decisions.An interactive web application was also developed to enable clinicians to input patient-specific molecular and clinical data and visualize individualized PFS predictions,supporting timely,data-driven treatment planning.
文摘Modern manufacturing processes have become more reliant on automation because of the accelerated transition from Industry 3.0 to Industry 4.0.Manual inspection of products on assembly lines remains inefficient,prone to errors and lacks consistency,emphasizing the need for a reliable and automated inspection system.Leveraging both object detection and image segmentation approaches,this research proposes a vision-based solution for the detection of various kinds of tools in the toolkit using deep learning(DL)models.Two Intel RealSense D455f depth cameras were arranged in a top down configuration to capture both RGB and depth images of the toolkits.After applying multiple constraints and enhancing them through preprocessing and augmentation,a dataset consisting of 3300 annotated RGB-D photos was generated.Several DL models were selected through a comprehensive assessment of mean Average Precision(mAP),precision-recall equilibrium,inference latency(target≥30 FPS),and computational burden,resulting in a preference for YOLO and Region-based Convolutional Neural Networks(R-CNN)variants over ViT-based models due to the latter’s increased latency and resource requirements.YOLOV5,YOLOV8,YOLOV11,Faster R-CNN,and Mask R-CNN were trained on the annotated dataset and evaluated using key performance metrics(Recall,Accuracy,F1-score,and Precision).YOLOV11 demonstrated balanced excellence with 93.0%precision,89.9%recall,and a 90.6%F1-score in object detection,as well as 96.9%precision,95.3%recall,and a 96.5%F1-score in instance segmentation with an average inference time of 25 ms per frame(≈40 FPS),demonstrating real-time performance.Leveraging these results,a YOLOV11-based windows application was successfully deployed in a real-time assembly line environment,where it accurately processed live video streams to detect and segment tools within toolkits,demonstrating its practical effectiveness in industrial automation.The application is capable of precisely measuring socket dimensions by utilising edge detection techniques on YOLOv11 segmentation masks,in addition to detection and segmentation.This makes it possible to do specification-level quality control right on the assembly line,which improves the ability to examine things in real time.The implementation is a big step forward for intelligent manufacturing in the Industry 4.0 paradigm.It provides a scalable,efficient,and accurate way to do automated inspection and dimensional verification activities.
基金supported by the National Natural Science Foundation of China,No.81972073(to HZ)a grant from the Taishan Scholars Program ofShandong Province-Young Taishan Scholars,No.tsqn201909197(to HZ)+1 种基金a grant from Tianjin Key Medical Discipline(Specialty)Construct Project,No.TJYXZDXK-027A(to SF)a grant from Academic Expert International Innovation Summit,No.22JRRCRC00010(to SF).
文摘Ferroptosis,a type of cell death that mainly involves iron metabolism imbalance and lipid peroxidation,is strongly correlated with the phagocytic response caused by bleeding after spinal cord injury.Thus,in this study,bulk RNA sequencing data(GSE47681 and GSE5296)and single-cell RNA sequencing data(GSE162610)were acquired from gene expression databases.We then conducted differential analysis and immune infiltration analysis.Atf3 and Piezo1 were identified as key ferroptosis genes through random forest and least absolute shrinkage and selection operator algorithms.Further analysis of single-cell RNA sequencing data revealed a close relationship between ferroptosis and cell types such as macrophages/microglia and their intrinsic state transition processes.Differences in transcription factor regulation and intercellular communication networks were found in ferroptosis-related cells,confirming the high expression of Atf3 and Piezo1 in these cells.Molecular docking analysis confirmed that the proteins encoded by these genes can bind cycloheximide.In a mouse model of T8 spinal cord injury,low-dose cycloheximide treatment was found to improve neurological function,decrease levels of the pro-inflammatory cytokine inducible nitric oxide synthase,and increase levels of the anti-inflammatory cytokine arginase 1.Correspondingly,the expression of the ferroptosis-related gene Gpx4 increased in macrophages/microglia,while the expression of Acsl4 decreased.Our findings reveal the important role of ferroptosis in the treatment of spinal cord injury,identify the key cell types and genes involved in ferroptosis after spinal cord injury,and validate the efficacy of potential drug therapies,pointing to new directions in the treatment of spinal cord injury.
基金supported by a project of the Shaanxi Youth Science and Technology Star(2021KJXX-87)public welfare geological survey projects of Shaanxi Institute of Geologic Survey(20180301,201918 and 202103)。
文摘With the efficient and intelligent development of computer-based big data processing,applying machine learning methods to the processing and interpretation of logging data in the field of geophysical well logging has broad potential for improving production efficiency.Currently,the Jiyuan Oilfield in the Ordos Basin relies mainly on manual reprocessing and interpretation of old well logging data to identify different fluid types in low-contrast reservoirs,guiding subsequent production work.This study uses well logging data from the Chang 1 reservoir,partitioning the dataset based on individual wells for model training and testing.A deep learning model for intelligent reservoir fluid identification was constructed by incorporating the focal loss function.Comparative validations with five other models,including logistic regression(LR),naive Bayes(NB),gradient boosting decision trees(GBDT),random forest(RF),and support vector machine(SVM),show that this model demonstrates superior identification performance and significantly improves the accuracy of identifying oil-bearing fluids.Mutual information analysis reveals the model's differential dependency on various logging parameters for reservoir fluid identification.This model provides important references and a basis for conducting regional studies and revisiting old wells,demonstrating practical value that can be widely applied.
文摘The current research was grounded in prior interdisciplinary research that showed cognitive ability (verbal ability for translating cognitions into oral language) and multiple-working memory endophenotypes (behavioral markers of genetic or brain bases of language learning) predict reading and writing achievement in students with and without specific learning disabilities in written language (SLDs-WL). Results largely replicated prior findings that verbally gifted with dyslexia score higher on reading and writing achievement than those with average verbal ability but not on endophenotypes. The current study extended that research by comparing those with and without SLDs-WL with assessed verbal ability held constant. The verbally gifted without SLDs-WL (n = 14) scored higher than the verbally gifted with SLDs-WL (n = 27) on six language skills (oral sentence construction, best and fastest handwriting in copying, single real word oral reading accuracy, oral pseudoword reading accuracy and rate) and four endophenotypes (orthographic and morphological coding, orthographic loop, and switching attention). The verbally average without SLDs-WL (n = 6) scored higher than the verbally average with SLDs-WL (n = 22) on four language skills (best and fastest hand-writing in copying, oral pseudoword reading accuracy and rate) and two endophenotypes (orthographic coding and orthographic loop). Implications of results for translating interdisciplinary research into flexible definitions for assessment and instruction to serve students with varying verbal abilities and language learning and endophenotype profiles are discussed along with directions for future research.
文摘The concept of Network Centric Therapy represents an amalgamation of wearable and wireless inertial sensor systems and machine learning with access to a Cloud computing environment. The advent of Network Centric Therapy is highly relevant to the treatment of Parkinson’s disease through deep brain stimulation. Originally wearable and wireless systems for quantifying Parkinson’s disease involved the use a smartphone to quantify hand tremor. Although originally novel, the smartphone has notable issues as a wearable application for quantifying movement disorder tremor. The smartphone has evolved in a pathway that has made the smartphone progressively more cumbersome to mount about the dorsum of the hand. Furthermore, the smartphone utilizes an inertial sensor package that is not certified for medical analysis, and the trial data access a provisional Cloud computing environment through an email account. These concerns are resolved with the recent development of a conformal wearable and wireless inertial sensor system. This conformal wearable and wireless system mounts to the hand with the profile of a bandage by adhesive and accesses a secure Cloud computing environment through a segmented wireless connectivity strategy involving a smartphone and tablet. Additionally, the conformal wearable and wireless system is certified by the FDA of the United States of America for ascertaining medical grade inertial sensor data. These characteristics make the conformal wearable and wireless system uniquely suited for the quantification of Parkinson’s disease treatment through deep brain stimulation. Preliminary evaluation of the conformal wearable and wireless system is demonstrated through the differentiation of deep brain stimulation set to “On” and “Off” status. Based on the robustness of the acceleration signal, this signal was selected to quantify hand tremor for the prescribed deep brain stimulation settings. Machine learning classification using the Waikato Environment for Knowledge Analysis (WEKA) was applied using the multilayer perceptron neural network. The multilayer perceptron neural network achieved considerable classification accuracy for distinguishing between the deep brain stimulation system set to “On” and “Off” status through the quantified acceleration signal data obtained by this recently developed conformal wearable and wireless system. The research achievement establishes a progressive pathway to the future objective of achieving deep brain stimulation capabilities that promote closed-loop acquisition of configuration parameters that are uniquely optimized to the individual through extrinsic means of a highly conformal wearable and wireless inertial sensor system and machine learning with access to Cloud computing resources.
文摘Using the latest available artificial intelligence (AI) technology, an advanced algorithm LIVERFAStTM has been used to evaluate the diagnostic accuracy of machine learning (ML) biomarker algorithms to assess liver damage. Prevalence of NAFLD (Nonalcoholic fatty liver disease) and resulting NASH (nonalcoholic steatohepatitis) are constantly increasing worldwide, creating challenges for screening as the diagnosis for NASH requires invasive liver biopsy. Key issues in NAFLD patients are the differentiation of NASH from simple steatosis and identification of advanced hepatic fibrosis. In this prospective study, the staging of three different lesions of the liver to diagnose fatty liver was analyzed using a proprietary ML algorithm LIVERFAStTM developed with a database of 2862 unique medical assessments of biomarkers, where 1027 assessments were used to train the algorithm and 1835 constituted the validation set. Data of 13,068 patients who underwent the LIVERFAStTM test for evaluation of fatty liver disease were analysed. Data evaluation revealed 11% of the patients exhibited significant fibrosis with fibrosis scores 0.6 - 1.00. Approximately 7% of the population had severe hepatic inflammation. Steatosis was observed in most patients, 63%, whereas severe steatosis S3 was observed in 20%. Using modified SAF (Steatosis, Activity and Fibrosis) scores obtained using the LIVERFAStTM algorithm, NAFLD was detected in 13.41% of the patients (Sx > 0, Ay 0). Approximately 1.91% (Sx > 0, Ay = 2, Fz > 0) of the patients showed NAFLD or NASH scorings while 1.08% had confirmed NASH (Sx > 0, Ay > 2, Fz = 1 - 2) and 1.49% had advanced NASH (Sx > 0, Ay > 2, Fz = 3 - 4). The modified SAF scoring system generated by LIVERFAStTM provides a simple and convenient evaluation of NAFLD and NASH in a cohort of Southeast Asians. This system may lead to the use of noninvasive liver tests in extended populations for more accurate diagnosis of liver pathology, prediction of clinical path of individuals at all stages of liver diseases, and provision of an efficient system for therapeutic interventions.
基金supported by a grant(No.CRPG-25-2054)under the Cybersecurity Research and Innovation Pioneers Initiative,provided by the National Cybersecurity Authority(NCA)in the Kingdom of Saudi Arabia.
文摘Split Learning(SL)has been promoted as a promising collaborative machine learning technique designed to address data privacy and resource efficiency.Specifically,neural networks are divided into client and server subnetworks in order to mitigate the exposure of sensitive data and reduce the overhead on client devices,thereby making SL particularly suitable for resource-constrained devices.Although SL prevents the direct transmission of raw data,it does not alleviate entirely the risk of privacy breaches.In fact,the data intermediately transmitted to the server sub-model may include patterns or information that could reveal sensitive data.Moreover,achieving a balance between model utility and data privacy has emerged as a challenging problem.In this article,we propose a novel defense approach that combines:(i)Adversarial learning,and(ii)Network channel pruning.In particular,the proposed adversarial learning approach is specifically designed to reduce the risk of private data exposure while maintaining high performance for the utility task.On the other hand,the suggested channel pruning enables the model to adaptively adjust and reactivate pruned channels while conducting adversarial training.The integration of these two techniques reduces the informativeness of the intermediate data transmitted by the client sub-model,thereby enhancing its robustness against attribute inference attacks without adding significant computational overhead,making it wellsuited for IoT devices,mobile platforms,and Internet of Vehicles(IoV)scenarios.The proposed defense approach was evaluated using EfficientNet-B0,a widely adopted compact model,along with three benchmark datasets.The obtained results showcased its superior defense capability against attribute inference attacks compared to existing state-of-the-art methods.This research’s findings demonstrated the effectiveness of the proposed channel pruning-based adversarial training approach in achieving the intended compromise between utility and privacy within SL frameworks.In fact,the classification accuracy attained by the attackers witnessed a drastic decrease of 70%.
文摘Adversarial Reinforcement Learning(ARL)models for intelligent devices and Network Intrusion Detection Systems(NIDS)improve systemresilience against sophisticated cyber-attacks.As a core component of ARL,Adversarial Training(AT)enables NIDS agents to discover and prevent newattack paths by exposing them to competing examples,thereby increasing detection accuracy,reducing False Positives(FPs),and enhancing network security.To develop robust decision-making capabilities for real-world network disruptions and hostile activity,NIDS agents are trained in adversarial scenarios to monitor the current state and notify management of any abnormal or malicious activity.The accuracy and timeliness of the IDS were crucial to the network’s availability and reliability at this time.This paper analyzes ARL applications in NIDS,revealing State-of-The-Art(SoTA)methodology,issues,and future research prospects.This includes Reinforcement Machine Learning(RML)-based NIDS,which enables an agent to interact with the environment to achieve a goal,andDeep Reinforcement Learning(DRL)-based NIDS,which can solve complex decision-making problems.Additionally,this survey study addresses cybersecurity adversarial circumstances and their importance for ARL and NIDS.Architectural design,RL algorithms,feature representation,and training methodologies are examined in the ARL-NIDS study.This comprehensive study evaluates ARL for intelligent NIDS research,benefiting cybersecurity researchers,practitioners,and policymakers.The report promotes cybersecurity defense research and innovation.
基金supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University(IMSIU)under the grant number IMSIU-DDRSP2601.
文摘Ovarian cancer(OC)is one of the leading causes of death related to gynecological cancer,with the main difficulty of its early diagnosis and a heterogeneous nature of tumor biomarkers.Machine learning(ML)has the potential to process complex datasets and support decision-making in OC diagnosis.Nevertheless,traditional ML models tend to be biased,overfitting,noisy,and less generalized.Moreover,their black-box nature reduces interpretability and limits their practical clinical applicability.In this study,we introduce an explainable ensemble learning(EL)model,TreeX-Stack,based on a stacking architecture that employs tree-based learners such as Decision Tree(DT),Random Forest(RF),Gradient Boosting(GB),and Extreme Gradient Boosting(XGBoost)as base learners,and Logistic Regression(LR)as the meta-learner to enhance ovarian cancer(OC)diagnosis.Local Interpretable ModelAgnostic Explanations(LIME)are used to explain individual predictions,making the model outputs more clinically interpretable and applicable.The model is trained on the dataset that includes demographic information,blood test,general chemistry,and tumor markers.Extensive preprocessing includes handling missing data using iterative imputation with Bayesian Ridge and addressing multicollinearity by removing features with correlation coefficients above 0.7.Relevant features are then selected using the Boruta feature selection method.To obtain robust and unbiased performance estimates during hyperparameter tuning,nested cross-validation(CV)with grid search is employed,and all experiments are repeated five times to ensure statistical reliability.TreeX-Stack demonstrates excellent diagnostic performance,achieving an accuracy of 0.9027,a precision of 0.8673,a recall of 0.9391,and an F1-score of 0.9012.Feature-importance analyses using LIME and permutation importance highlight Human Epididymis Protein 4(HE4)as the most significant biomarker for OC.The combination of high predictive performance and interpretability makes TreeX-Stack a reliable tool for clinical decision support in OC diagnosis.
基金the research project LaTe4PoliticES(PID2022-138099OB-I00)funded by MCIN/AEI/10.13039/501100011033 and the European Fund for Regional Development(ERDF)-a way to make Europe.Tomás Bernal-Beltrán is supported by University of Murcia through the predoctoral programme.
文摘The malicious dissemination of hate speech via compromised accounts,automated bot networks and malware-driven social media campaigns has become a growing cybersecurity concern.Automatically detecting such content in Spanish is challenging due to linguistic complexity and the scarcity of annotated resources.In this paper,we compare two predominant AI-based approaches for the forensic detection of malicious hate speech:(1)finetuning encoder-only models that have been trained in Spanish and(2)In-Context Learning techniques(Zero-and Few-Shot Learning)with large-scale language models.Our approach goes beyond binary classification,proposing a comprehensive,multidimensional evaluation that labels each text by:(1)type of speech,(2)recipient,(3)level of intensity(ordinal)and(4)targeted group(multi-label).Performance is evaluated using an annotated Spanish corpus,standard metrics such as precision,recall and F1-score and stability-oriented metrics to evaluate the stability of the transition from zero-shot to few-shot prompting(Zero-to-Few Shot Retention and Zero-to-Few Shot Gain)are applied.The results indicate that fine-tuned encoder-only models(notably MarIA and BETO variants)consistently deliver the strongest and most reliable performance:in our experiments their macro F1-scores lie roughly in the range of approximately 46%–66%depending on the task.Zero-shot approaches are much less stable and typically yield substantially lower performance(observed F1-scores range approximately 0%–39%),often producing invalid outputs in practice.Few-shot prompting(e.g.,Qwen 38B,Mistral 7B)generally improves stability and recall relative to pure zero-shot,bringing F1-scores into a moderate range of approximately 20%–51%but still falling short of fully fine-tuned models.These findings highlight the importance of supervised adaptation and discuss the potential of both paradigms as components in AI-powered cybersecurity and malware forensics systems designed to identify and mitigate coordinated online hate campaigns.
