Among various architectures of polymers,end-group-free rings have attracted growing interests due to their distinct physicochemical performances over the linear counterparts which are exemplified by reduced hydrodynam...Among various architectures of polymers,end-group-free rings have attracted growing interests due to their distinct physicochemical performances over the linear counterparts which are exemplified by reduced hydrodynamic size and slower degradation.It is key to develop facile methods to large-scale synthesis of polymer rings with tunable compositions and microstructures.Recent progresses in large-scale synthesis of polymer rings against single-chain dynamic nanoparticles,and the example applications in synchronous enhancing toughness and strength of polymer nanocomposites are summarized.Once there is the breakthrough in rational design and effective large-scale synthesis of polymer rings and their functional derivatives,a family of cyclic functional hybrids would be available,thus providing a new paradigm in developing polymer science and engineering.展开更多
Large-scale complex systems are integral to the functioning of various organizations within the national economy.Despite their significance,the lengthy construction cycles and the involvement of multiple entities ofte...Large-scale complex systems are integral to the functioning of various organizations within the national economy.Despite their significance,the lengthy construction cycles and the involvement of multiple entities often result in the deprioritization of standardized management practices,as they do not yield immediate benefits.The implementation of such systems typically encompasses the integrated phases of "development,construction,utiliz ation,and operation and maintenance".To enhance the overall delivery quality of these systems,it is imperative to dismantle the management barriers among these phases and adopt a holistic approach to standardized management.This paper takes a specific system project as a research object to identify common challenges,and proposes improvement strategies in the implementation of standar dized management.Empirical results indicate a substantial reduction in the system s full-lifecycle costs.展开更多
Summer rainfall in the Yangtze River basin(YRB)is favored by two key factors in the lower troposphere:the tropical anticyclonic anomaly over the western North Pacific and the extratropical northeasterly anomalies to t...Summer rainfall in the Yangtze River basin(YRB)is favored by two key factors in the lower troposphere:the tropical anticyclonic anomaly over the western North Pacific and the extratropical northeasterly anomalies to the north of the YRB.This study,however,found that approximately 46%of heavy rainfall events in the YRB occur when only one factor appears and the other is opposite signed.Accordingly,these heavy rainfall events can be categorized into two types:the extratropical northeasterly anomalies but tropical cyclonic anomaly(first unconventional type),and the tropical anticyclonic anomaly but extratropical southwesterly anomalies(second unconventional type).Anomalous water vapor convergence and upward motion exists for both types,but through different mechanisms.For the first type,the moisture convergence and upward motion are induced by a cyclonic anomaly over the YRB,which appears in the mid and lower troposphere and originates from the upstream region.For the second type,a mid-tropospheric cyclonic anomaly over Lake Baikal extends southward and results in southwesterly anomalies over the YRB,in conjunction with the tropical anticyclonic anomaly.The southwesterly anomalies transport water vapor to the YRB and lead to upward motion through warm advection.This study emphasizes the role of mid-tropospheric circulations in inducing heavy rainfall in the YRB.展开更多
Portable ratiometric fluorescent platforms have emerged as promising tools for multifarious detection,yet remain unexplored for point-of-care monitoring doxorubicin(DOX),one of clinically antineoplastic drugs.To this ...Portable ratiometric fluorescent platforms have emerged as promising tools for multifarious detection,yet remain unexplored for point-of-care monitoring doxorubicin(DOX),one of clinically antineoplastic drugs.To this end,we herein develop a portable self-calibrating platform namely carbon dots(C-dots)-embedded hydrogel sensors with a smartphone-assisted high-throughput imaging device,for DOX sensing.The prepared green-emitting(λ_(em)=508 nm)and negatively-charged C-dots(−11.40±1.21 mV),which have sufficient spectral overlap with the absorption band of DOX(∼500 nm),can strongly bind with positively-charged DOX molecules by electrostatic attraction effects.As a result,DOX molecules are selectively and rapid(20 s)determined with a detection limit of 10.26 nmol/L via Förster resonance energy transfer processes,demonstrating a remarkably chromatic shift from green to red.Further integrated with a 3D-printed smartphone-assisted device,the platform enabled high-throughput quantification,achieving recoveries of 96.40%-101.85%in human urine/serum(RSDs<2.94%,n=3).Notably,the dual linear detection ranges of the platform align with the reported clinical DOX concentrations in urine and plasma(0-4 h post-administration),validating their capability for direct quantification of DOX in clinical samples without special pre-treatment processes.By virtue of attractive analytical performances and robust feasibility,this platform bridges laboratory precision and point-of-care testing needs,offering promising potential for personalized chemotherapy and multiplexed analyte screening.展开更多
This study develops an event-triggered control strategy utilizing the fully actuated system approach for nonlinear interconnected large-scale systems containing actuator failures.First,to reduce the complexity of the ...This study develops an event-triggered control strategy utilizing the fully actuated system approach for nonlinear interconnected large-scale systems containing actuator failures.First,to reduce the complexity of the design process,we transform the studied system into the form of a fully actuated system through a state transformation.Then,to address the unknown nonlinear functions and actuator fault parameters,we employ neural networks and adaptive estimation techniques,respectively.Moreover,to reduce the control cost and improve the control efficiency,we introduce event-triggered inputs into the control strategy.It is proved by the Lyapunov stability analysis that all signals of the closed-loop system are bounded and the output of system eventually converge to a bounded region.The efficacy of the control approach is ultimately demonstrated via the simulation of an actual machine feeding system.展开更多
As one of the major volatile components in extraterrestrial materials,nitrogen(N_(2))isotopes serve not only as tracers for the formation and evolution of the solar system,but also play a critical role in assessing pl...As one of the major volatile components in extraterrestrial materials,nitrogen(N_(2))isotopes serve not only as tracers for the formation and evolution of the solar system,but also play a critical role in assessing planetary habitability and the search for extraterrestrial life.The integrated measurement of N_(2)and argon(Ar)isotopes by using noble gas mass spectrometry represents a state-of-the-art technique for such investigations.To support the growing demands of planetary science research in China,we have developed a high-efficiency,high-precision method for the integrated analysis of N_(2)and Ar isotopes.This was achieved by enhancing gas extraction and purification systems and integrating them with a static noble gas mass spectrometer.This method enables integrated N_(2)-Ar isotope measurements on submilligram samples,significantly improving sample utilization and reducing the impact of sample heterogeneity on volatile analysis.The system integrates CO_(2)laser heating,a modular two-stage Zr-Al getter pump,and a CuO furnace-based purification process,effectively reducing background levels(N_(2)blank as low as 0.35×10^(−6)cubic centimeters at standard temperature and pressure[ccSTP]).Analytical precision is ensured through calibration with atmospheric air and CO corrections.To validate the reliability of the method,we performed N_(2)-Ar isotope analyses on the Allende carbonaceous chondrite,one of the most extensively studied meteorites internationally.The measured N_(2)concentrations range from 19.2 to 29.8 ppm,withδ15N values between−44.8‰and−33.0‰.Concentrations of 40Ar,36Ar,and 38Ar are(12.5-21.1)×10^(−6)ccSTP/g,(90.9-150.3)×10^(−9)ccSTP/g,and(19.2-30.7)×10^(−9)ccSTP/g,respectively.These values correspond to cosmic-ray exposure ages of 4.5-5.7 Ma,consistent with previous reports.Step-heating experiments further reveal distinct release patterns of N and Ar isotopes,as well as their associations with specific mineral phases in the meteorite.In summary,the combined N_(2)-Ar isotopic system offers significant advantages for tracing volatile sources in extraterrestrial materials and will provide essential analytical support for upcoming Chinese planetary missions,such as Tianwen-2.展开更多
Distribution transformers play a vital role in power distribution systems,and their reliable operation is crucial for grid stability.This study presents a simulation-based framework for active fault diagnosis and earl...Distribution transformers play a vital role in power distribution systems,and their reliable operation is crucial for grid stability.This study presents a simulation-based framework for active fault diagnosis and early warning of distribution transformers,integrating Sample Ensemble Learning(SEL)with a Self-Optimizing Support Vector Machine(SO-SVM).The SEL technique enhances data diversity and mitigates class imbalance,while SO-SVM adaptively tunes its hyperparameters to improve classification accuracy.A comprehensive transformer model was developed in MATLAB/Simulink to simulate diverse fault scenarios,including inter-turn winding faults,core saturation,and thermal aging.Feature vectors were extracted from voltage,current,and temperature measurements to train and validate the proposed hybrid model.Quantitative analysis shows that the SEL–SO-SVM framework achieves a classification accuracy of 97.8%,a precision of 96.5%,and an F1-score of 97.2%.Beyond classification,the model effectively identified incipient faults,providing an early warning lead time of up to 2.5 s before significant deviations in operational parameters.This predictive capability underscores its potential for preventing catastrophic transformer failures and enabling timely maintenance actions.The proposed approach demonstrates strong applicability for enhancing the reliability and operational safety of distribution transformers in simulated environments,offering a promising foundation for future real-time and field-level implementations.展开更多
sing the natural limestone samples taken from the field with dimension of 500 mm×500 mm×1 000 mm, the D-D (dilatancy-diffusion) seismogeny pattern was modeled under the condition of water injection, which ob...sing the natural limestone samples taken from the field with dimension of 500 mm×500 mm×1 000 mm, the D-D (dilatancy-diffusion) seismogeny pattern was modeled under the condition of water injection, which observes the time-space evolutionary features about the relative physics fields of the loaded samples from deformation, formation of microcracks to the occurrence of main rupture. The results of observed apparent resistivity show: ① The process of the deformation from microcrack to main rupture on the loaded rock sample could be characterized by the precursory spatial-temporal changes in the observation of apparent resistivity; ② The precursory temporal changes of observation in apparent resistivity could be divided into several stages, and its spatial distribution shows the difference in different parts of the rock sample; ③ Before the main rupture of the rock sample the obvious ″tendency anomaly′ and ′short-term anomaly″ were observed, and some of them could be likely considered as the ″impending earthquake ″anomaly precursor of apparent resistivity. The changes and distribution features of apparent resistivity show that they are intrinsically related to the dilatancy phenomenon of the loaded rock sample. Finally, this paper discusses the mechanism of resistivity change of loaded rock sample theoretically.展开更多
The distributed passive measurement is an important technology for networkbehavior research. To achieve a consistent measurement, the same packets should be sampled atdistributed measurement points. And in order to es...The distributed passive measurement is an important technology for networkbehavior research. To achieve a consistent measurement, the same packets should be sampled atdistributed measurement points. And in order to estimate the character of traffic statistics, thetraffic sample should be random in statistics. A distributed samplingmask measurement model isintroduced to tackle the difficulty of measuring the full trace of high-speed networks. The keypoint of the model is to choose some bits that are suitable to be sampling mask. In the paper, thebit entropy and bit flow entropy of IP packet headers in CERNET backbone are analyzed, and we findthat the 16 bits of identification field in IP packet header are fit to the matching field ofsampling mask. Measurement traffic also can be used to analyze the statistical character ofmeasurement sample and the randomicity of the model. At the same time the experiment resultsindicate that the model has a good sampling performance.展开更多
1.Introduction Climate change mitigation pathways aimed at limiting global anthropogenic carbon dioxide(CO_(2))emissions while striving to constrain the global temperature increase to below 2℃—as outlined by the Int...1.Introduction Climate change mitigation pathways aimed at limiting global anthropogenic carbon dioxide(CO_(2))emissions while striving to constrain the global temperature increase to below 2℃—as outlined by the Intergovernmental Panel on Climate Change(IPCC)—consistently predict the widespread implementation of CO_(2)geological storage on a global scale.展开更多
The recent upsurge in metro construction emphasizes the necessity of understanding the mechanical performance of metro shield tunnel subjected to the influence of ground fissures.In this study,a largescale experiment,...The recent upsurge in metro construction emphasizes the necessity of understanding the mechanical performance of metro shield tunnel subjected to the influence of ground fissures.In this study,a largescale experiment,in combination with numerical simulation,was conducted to investigate the influence of ground fissures on a metro shield tunnel.The results indicate that the lining contact pressure at the vault increases in the hanging wall while decreases in the footwall,resulting in a two-dimensional stress state of vertical shear and axial tension-compression,and simultaneous vertical dislocation and axial tilt for the segments around the ground fissure.In addition,the damage to curved bolts includes tensile yield,flexural yield,and shear twist,leading to obvious concrete lining damage,particularly at the vault,arch bottom,and hance,indicating that the joints in these positions are weak areas.The shield tunnel orthogonal to the ground fissure ultimately experiences shear failure,suggesting that the maximum actual dislocation of ground fissure that the structure can withstand is approximately 20 cm,and five segment rings in the hanging wall and six segment rings in the footwall also need to be reinforced.This study could provide a reference for metro design in ground fissure sites.展开更多
Marine gas hydrates are highly sensitive to temperature and pressure fluctuations,and deviations from in-situ conditions may cause irreversible changes in phase state,microstructure,and mechanical properties.However,c...Marine gas hydrates are highly sensitive to temperature and pressure fluctuations,and deviations from in-situ conditions may cause irreversible changes in phase state,microstructure,and mechanical properties.However,conventional samplers often fail to maintain sealing and thermal stability,resulting in low sampling success rates.To address these challenges,an in-situ temperature-and pressure-preserved sampler for marine applications has been developed.The experimental results indicate that the selfdeveloped magnetically controlled pressure-preserved controller reliably achieves autonomous triggering and self-sealing,provides an initial sealing force of 83 N,and is capable of maintaining pressures up to 40 MPa.Additionally,a custom-designed intelligent temperature control chip and high-precision sensors were integrated into the sampler.Through the design of an optimized heat transfer structure,a temperature-preserved system was developed,achieving no more than a 0.3℃ rise in temperature within 2 h.The performance evaluation and sampling operations of the sampler were conducted at the Haima Cold Seep in the South China Sea,resulting in the successful recovery of hydrate maintained under in-situ pressure of 13.8 MPa and a temperature of 6.5℃.This advancement enables the acquisition of high-fidelity hydrate samples,providing critical support for the safe exploitation and scientific analysis of marine gas hydrate resources.展开更多
Based on the analysis of typical lacustrine shale oil zones in China and their geological characteristics,this study elucidates the fundamental differences between the enrichment patterns of shale oil sweet spots and ...Based on the analysis of typical lacustrine shale oil zones in China and their geological characteristics,this study elucidates the fundamental differences between the enrichment patterns of shale oil sweet spots and conventional oil and gas.The key parameters and evaluation methods for assessing the large-scale production potential of lacustrine shale oil are proposed.The results show that shale oil is a petroleum resource that exists in organic-rich shale formations,in other words,it is preserved in its source bed,following a different process of generation-accumulation-enrichment from conventional oil and gas.Thus,the concept of“reservoir”seems to be inapplicable to shale oil.In China,lacustrine shale oil is distributed widely,but the geological characteristics and sweet spots enrichment patterns of shale oil vary significantly in lacustrine basins where the water environment and the tectonic evolution and diagenetic transformation frameworks are distinct.The core of the evaluation of lacustrine shale oil is“sweet spot volume”.The key factors for evaluating the large-scale production of continental shale oil are the oil storage capacity,oil-bearing capacity and oil producing capacity.The key parameters for evaluating these capacities are total porosity,oil content,and free oil content,respectively.It is recommended to determine the total porosity of shale by combining helium porosity measurement with nuclear magnetic resonance(NMR)method,the oil content of key layers by using organic solvent extraction,NMR method and high pressure mercury intrusion methods,and the free oil content by using NMR fluid distribution secondary spectral stripping decomposition and logging.The research results contribute supplemental insights on continental shale oil deliverability in China,and provide a scientific basis for the rapid exploration and large-scale production of lacustrine shale oil.展开更多
The titanium alloy strut serves as a key load-bearing component of aircraft landing gear,typically manufactured via forging.The friction condition has important influence on material flow and cavity filling during the...The titanium alloy strut serves as a key load-bearing component of aircraft landing gear,typically manufactured via forging.The friction condition has important influence on material flow and cavity filling during the forging process.Using the previously optimized shape and initial position of preform,the influence of the friction condition(friction factor m=0.1–0.3)on material flow and cavity filling was studied by numerical method with a shear friction model.A novel filling index was defined to reflect material flow into left and right flashes and zoom in on friction-induced results.The results indicate that the workpiece moves rigidly to the right direction,with the displacement decreasing as m increases.When m<0.18,the underfilling defect will occur in the left side of strut forging,while overflow occurs in the right forging die cavity.By combining the filling index and analyses of material flow and filling status,a reasonable friction factor interval of m=0.21–0.24 can be determined.Within this interval,the cavity filling behavior demonstrates robustness,with friction fluctuations exerting minimal influence.展开更多
This paper proposes a non-intrusive computational method for mechanical dynamic systems involving a large-scale of interval uncertain parameters,aiming to reduce the computational costs and improve accuracy in determi...This paper proposes a non-intrusive computational method for mechanical dynamic systems involving a large-scale of interval uncertain parameters,aiming to reduce the computational costs and improve accuracy in determining bounds of system response.The screening method is firstly used to reduce the scale of active uncertain parameters.The sequential high-order polynomials surrogate models are then used to approximate the dynamic system’s response at each time step.To reduce the sampling cost of constructing surrogate model,the interaction effect among uncertain parameters is gradually added to the surrogate model by sequentially incorporating samples from a candidate set,which is composed of vertices and inner grid points.Finally,the points that may produce the bounds of the system response at each time step are searched using the surrogate models.The optimization algorithm is used to locate extreme points,which contribute to determining the inner points producing system response bounds.Additionally,all vertices are also checked using the surrogate models.A vehicle nonlinear dynamic model with 72 uncertain parameters is presented to demonstrate the accuracy and efficiency of the proposed uncertain computational method.展开更多
Three-dimensional printing(3DP)offers valuable insight into the characterization of natural rocks and the verification of theoretical models due to its high reproducibility and accurate replication of complex defects ...Three-dimensional printing(3DP)offers valuable insight into the characterization of natural rocks and the verification of theoretical models due to its high reproducibility and accurate replication of complex defects such as cracks and pores.In this study,3DP gypsum samples with different printing directions were subjected to a series of uniaxial compression tests with in situ micro-computed tomography(micro-CT)scanning to quantitatively investigate their mechanical anisotropic properties and damage evolution characteristics.Based on the two-dimensional(2D)CT images obtained at different scanning steps,a novel void ratio variable was derived using the mean value and variance of CT intensity.Additionally,a constitutive model was formulated incorporating the proposed damage variable,utilizing the void ratio variable.The crack evolution and crack morphology of 3DP gypsum samples were obtained and analyzed using the 3D models reconstructed from the CT images.The results indicate that 3DP gypsum samples exhibit mechanical anisotropic characteristics similar to those found in naturally sedimentary rocks.The mechanical anisotropy is attributed to the bedding planes formed between adjacent layers and pillar-like structures along the printing direction formed by CaSO_(4)·2H_(2)O crystals of needle-like morphology.The mean gray intensity of the voids has a positive linear relationship with the threshold value,while the CT variance and void ratio have concave and convex relationships,respectively.The constitutive model can effectively match the stress–strain curves obtained from uniaxial compression experiments.This study provides comprehensive explanations of the failure modes and anisotropic mechanisms of 3DP gypsum samples,which is important for characterizing and understanding the failure mechanism and microstructural evolution of 3DP rocks when modeling natural rock behavior.展开更多
Industrial data mining usually deals with data from different sources.These heterogeneous datasets describe the same object in different views.However,samples from some of the datasets may be lost.Then the remaining s...Industrial data mining usually deals with data from different sources.These heterogeneous datasets describe the same object in different views.However,samples from some of the datasets may be lost.Then the remaining samples do not correspond one-to-one correctly.Mismatched datasets caused by missing samples make the industrial data unavailable for further machine learning.In order to align the mismatched samples,this article presents a cooperative iteration matching method(CIMM)based on the modified dynamic time warping(DTW).The proposed method regards the sequentially accumulated industrial data as the time series.Mismatched samples are aligned by the DTW.In addition,dynamic constraints are applied to the warping distance of the DTW process to make the alignment more efficient.Then a series of models are trained with the cumulated samples iteratively.Several groups of numerical experiments on different missing patterns and missing locations are designed and analyzed to prove the effectiveness and the applicability of the proposed method.展开更多
Based on questionnaire surveys and field interviews conducted with various types of agricultural production organizations across five districts and four counties in Daqing City,this study combines relevant theoretical...Based on questionnaire surveys and field interviews conducted with various types of agricultural production organizations across five districts and four counties in Daqing City,this study combines relevant theoretical frameworks to systematically examine the evolution,performance,and influencing factors of governance mechanisms within these organizations.Using both quantitative and inductive analytical methods,the paper proposes innovative designs and supporting measures for improving governance mechanisms.The findings reveal that,amid large-scale farmland circulation,the governance mechanisms of agricultural production organizations in Daqing City are evolving from traditional to modern structures.However,challenges remain in areas such as decision-making efficiency,benefit distribution,and supervision mechanisms.In response,this study proposes innovative governance designs focusing on decision-making processes,profit-sharing mechanisms,and risk prevention.Corresponding policy recommendations are also provided to support the sustainable development of agricultural modernization in China.展开更多
Formalizing complex processes and phenomena of a real-world problem may require a large number of variables and constraints,resulting in what is termed a large-scale optimization problem.Nowadays,such large-scale opti...Formalizing complex processes and phenomena of a real-world problem may require a large number of variables and constraints,resulting in what is termed a large-scale optimization problem.Nowadays,such large-scale optimization problems are solved using computing machines,leading to an enormous computational time being required,which may delay deriving timely solutions.Decomposition methods,which partition a large-scale optimization problem into lower-dimensional subproblems,represent a key approach to addressing time-efficiency issues.There has been significant progress in both applied mathematics and emerging artificial intelligence approaches on this front.This work aims at providing an overview of the decomposition methods from both the mathematics and computer science points of view.We also remark on the state-of-the-art developments and recent applications of the decomposition methods,and discuss the future research and development perspectives.展开更多
基金Supported by the National Natural Science Foundation of China(Nos.52293472,22473096 and 22471164)。
文摘Among various architectures of polymers,end-group-free rings have attracted growing interests due to their distinct physicochemical performances over the linear counterparts which are exemplified by reduced hydrodynamic size and slower degradation.It is key to develop facile methods to large-scale synthesis of polymer rings with tunable compositions and microstructures.Recent progresses in large-scale synthesis of polymer rings against single-chain dynamic nanoparticles,and the example applications in synchronous enhancing toughness and strength of polymer nanocomposites are summarized.Once there is the breakthrough in rational design and effective large-scale synthesis of polymer rings and their functional derivatives,a family of cyclic functional hybrids would be available,thus providing a new paradigm in developing polymer science and engineering.
文摘Large-scale complex systems are integral to the functioning of various organizations within the national economy.Despite their significance,the lengthy construction cycles and the involvement of multiple entities often result in the deprioritization of standardized management practices,as they do not yield immediate benefits.The implementation of such systems typically encompasses the integrated phases of "development,construction,utiliz ation,and operation and maintenance".To enhance the overall delivery quality of these systems,it is imperative to dismantle the management barriers among these phases and adopt a holistic approach to standardized management.This paper takes a specific system project as a research object to identify common challenges,and proposes improvement strategies in the implementation of standar dized management.Empirical results indicate a substantial reduction in the system s full-lifecycle costs.
基金supported by the National Natural Science Foundation of China(Grant No.42275041)the Hainan Province Science and Technology Special Fund(Grant No.SOLZSKY2025006).
文摘Summer rainfall in the Yangtze River basin(YRB)is favored by two key factors in the lower troposphere:the tropical anticyclonic anomaly over the western North Pacific and the extratropical northeasterly anomalies to the north of the YRB.This study,however,found that approximately 46%of heavy rainfall events in the YRB occur when only one factor appears and the other is opposite signed.Accordingly,these heavy rainfall events can be categorized into two types:the extratropical northeasterly anomalies but tropical cyclonic anomaly(first unconventional type),and the tropical anticyclonic anomaly but extratropical southwesterly anomalies(second unconventional type).Anomalous water vapor convergence and upward motion exists for both types,but through different mechanisms.For the first type,the moisture convergence and upward motion are induced by a cyclonic anomaly over the YRB,which appears in the mid and lower troposphere and originates from the upstream region.For the second type,a mid-tropospheric cyclonic anomaly over Lake Baikal extends southward and results in southwesterly anomalies over the YRB,in conjunction with the tropical anticyclonic anomaly.The southwesterly anomalies transport water vapor to the YRB and lead to upward motion through warm advection.This study emphasizes the role of mid-tropospheric circulations in inducing heavy rainfall in the YRB.
基金supported by the National NaturalScience Foundation of China(No.22274001)the Key Project of Natural Science Research of the Education Department of Anhui Province(No.2022AH051032)the Excellent Research and Innovation Team of Universities in Anhui Province(No.2024AH010016).
文摘Portable ratiometric fluorescent platforms have emerged as promising tools for multifarious detection,yet remain unexplored for point-of-care monitoring doxorubicin(DOX),one of clinically antineoplastic drugs.To this end,we herein develop a portable self-calibrating platform namely carbon dots(C-dots)-embedded hydrogel sensors with a smartphone-assisted high-throughput imaging device,for DOX sensing.The prepared green-emitting(λ_(em)=508 nm)and negatively-charged C-dots(−11.40±1.21 mV),which have sufficient spectral overlap with the absorption band of DOX(∼500 nm),can strongly bind with positively-charged DOX molecules by electrostatic attraction effects.As a result,DOX molecules are selectively and rapid(20 s)determined with a detection limit of 10.26 nmol/L via Förster resonance energy transfer processes,demonstrating a remarkably chromatic shift from green to red.Further integrated with a 3D-printed smartphone-assisted device,the platform enabled high-throughput quantification,achieving recoveries of 96.40%-101.85%in human urine/serum(RSDs<2.94%,n=3).Notably,the dual linear detection ranges of the platform align with the reported clinical DOX concentrations in urine and plasma(0-4 h post-administration),validating their capability for direct quantification of DOX in clinical samples without special pre-treatment processes.By virtue of attractive analytical performances and robust feasibility,this platform bridges laboratory precision and point-of-care testing needs,offering promising potential for personalized chemotherapy and multiplexed analyte screening.
基金supported by the Science Center Program of National Natural Science Foundation of China under Grant 62188101the National Natural Science Foundation of China under Grant 62573265.
文摘This study develops an event-triggered control strategy utilizing the fully actuated system approach for nonlinear interconnected large-scale systems containing actuator failures.First,to reduce the complexity of the design process,we transform the studied system into the form of a fully actuated system through a state transformation.Then,to address the unknown nonlinear functions and actuator fault parameters,we employ neural networks and adaptive estimation techniques,respectively.Moreover,to reduce the control cost and improve the control efficiency,we introduce event-triggered inputs into the control strategy.It is proved by the Lyapunov stability analysis that all signals of the closed-loop system are bounded and the output of system eventually converge to a bounded region.The efficacy of the control approach is ultimately demonstrated via the simulation of an actual machine feeding system.
基金supported by the Bureau of Frontier Sciences and Basic Research,Chinese Academy of Sciences(Grant No.QYJ-2025-0103)the National Natural Science Foundation of China(Grant Nos.42441834,42241105,42441825,and 42203048)the Key Research Program of the Institute of Geology and Geophysics,Chinese Academy of Sciences(Grant No.IGGCAS-202401).
文摘As one of the major volatile components in extraterrestrial materials,nitrogen(N_(2))isotopes serve not only as tracers for the formation and evolution of the solar system,but also play a critical role in assessing planetary habitability and the search for extraterrestrial life.The integrated measurement of N_(2)and argon(Ar)isotopes by using noble gas mass spectrometry represents a state-of-the-art technique for such investigations.To support the growing demands of planetary science research in China,we have developed a high-efficiency,high-precision method for the integrated analysis of N_(2)and Ar isotopes.This was achieved by enhancing gas extraction and purification systems and integrating them with a static noble gas mass spectrometer.This method enables integrated N_(2)-Ar isotope measurements on submilligram samples,significantly improving sample utilization and reducing the impact of sample heterogeneity on volatile analysis.The system integrates CO_(2)laser heating,a modular two-stage Zr-Al getter pump,and a CuO furnace-based purification process,effectively reducing background levels(N_(2)blank as low as 0.35×10^(−6)cubic centimeters at standard temperature and pressure[ccSTP]).Analytical precision is ensured through calibration with atmospheric air and CO corrections.To validate the reliability of the method,we performed N_(2)-Ar isotope analyses on the Allende carbonaceous chondrite,one of the most extensively studied meteorites internationally.The measured N_(2)concentrations range from 19.2 to 29.8 ppm,withδ15N values between−44.8‰and−33.0‰.Concentrations of 40Ar,36Ar,and 38Ar are(12.5-21.1)×10^(−6)ccSTP/g,(90.9-150.3)×10^(−9)ccSTP/g,and(19.2-30.7)×10^(−9)ccSTP/g,respectively.These values correspond to cosmic-ray exposure ages of 4.5-5.7 Ma,consistent with previous reports.Step-heating experiments further reveal distinct release patterns of N and Ar isotopes,as well as their associations with specific mineral phases in the meteorite.In summary,the combined N_(2)-Ar isotopic system offers significant advantages for tracing volatile sources in extraterrestrial materials and will provide essential analytical support for upcoming Chinese planetary missions,such as Tianwen-2.
文摘Distribution transformers play a vital role in power distribution systems,and their reliable operation is crucial for grid stability.This study presents a simulation-based framework for active fault diagnosis and early warning of distribution transformers,integrating Sample Ensemble Learning(SEL)with a Self-Optimizing Support Vector Machine(SO-SVM).The SEL technique enhances data diversity and mitigates class imbalance,while SO-SVM adaptively tunes its hyperparameters to improve classification accuracy.A comprehensive transformer model was developed in MATLAB/Simulink to simulate diverse fault scenarios,including inter-turn winding faults,core saturation,and thermal aging.Feature vectors were extracted from voltage,current,and temperature measurements to train and validate the proposed hybrid model.Quantitative analysis shows that the SEL–SO-SVM framework achieves a classification accuracy of 97.8%,a precision of 96.5%,and an F1-score of 97.2%.Beyond classification,the model effectively identified incipient faults,providing an early warning lead time of up to 2.5 s before significant deviations in operational parameters.This predictive capability underscores its potential for preventing catastrophic transformer failures and enabling timely maintenance actions.The proposed approach demonstrates strong applicability for enhancing the reliability and operational safety of distribution transformers in simulated environments,offering a promising foundation for future real-time and field-level implementations.
文摘sing the natural limestone samples taken from the field with dimension of 500 mm×500 mm×1 000 mm, the D-D (dilatancy-diffusion) seismogeny pattern was modeled under the condition of water injection, which observes the time-space evolutionary features about the relative physics fields of the loaded samples from deformation, formation of microcracks to the occurrence of main rupture. The results of observed apparent resistivity show: ① The process of the deformation from microcrack to main rupture on the loaded rock sample could be characterized by the precursory spatial-temporal changes in the observation of apparent resistivity; ② The precursory temporal changes of observation in apparent resistivity could be divided into several stages, and its spatial distribution shows the difference in different parts of the rock sample; ③ Before the main rupture of the rock sample the obvious ″tendency anomaly′ and ′short-term anomaly″ were observed, and some of them could be likely considered as the ″impending earthquake ″anomaly precursor of apparent resistivity. The changes and distribution features of apparent resistivity show that they are intrinsically related to the dilatancy phenomenon of the loaded rock sample. Finally, this paper discusses the mechanism of resistivity change of loaded rock sample theoretically.
基金Supported by National Basic Research Program of China （973 Program） （2009CB320601）, National Natural Science Foundation of China （60774048, 60821063）, the Program for Cheung Kong Scholars, and the Research Fund for the Doctoral Program of China Higher Education （20070145015）
文摘这份报纸学习样品数据的问题为有变化时间的延期的不明确的连续时间的模糊大规模系统的可靠 H 夸张控制。第一，模糊夸张模型( FHM )被用来为某些复杂大规模系统建立模型，然后根据 Lyapunov 指导方法和大规模系统的分散的控制理论，线性 matrixine 质量( LMI )基于条件 arederived toguarantee H 性能不仅当所有控制部件正在操作很好时，而且面对一些可能的致动器失败。而且，致动器的精确失败参数没被要求，并且要求仅仅是失败参数的更低、上面的界限。条件依赖于时间延期的上面的界限，并且不依赖于变化时间的延期的衍生物。因此，获得的结果是不太保守的。最后，二个例子被提供说明设计过程和它的有效性。
文摘The distributed passive measurement is an important technology for networkbehavior research. To achieve a consistent measurement, the same packets should be sampled atdistributed measurement points. And in order to estimate the character of traffic statistics, thetraffic sample should be random in statistics. A distributed samplingmask measurement model isintroduced to tackle the difficulty of measuring the full trace of high-speed networks. The keypoint of the model is to choose some bits that are suitable to be sampling mask. In the paper, thebit entropy and bit flow entropy of IP packet headers in CERNET backbone are analyzed, and we findthat the 16 bits of identification field in IP packet header are fit to the matching field ofsampling mask. Measurement traffic also can be used to analyze the statistical character ofmeasurement sample and the randomicity of the model. At the same time the experiment resultsindicate that the model has a good sampling performance.
基金supported by the National Key Research and Development Program of China(2022YFE0206700)。
文摘1.Introduction Climate change mitigation pathways aimed at limiting global anthropogenic carbon dioxide(CO_(2))emissions while striving to constrain the global temperature increase to below 2℃—as outlined by the Intergovernmental Panel on Climate Change(IPCC)—consistently predict the widespread implementation of CO_(2)geological storage on a global scale.
基金supported by the National Key Research&Development Program of China(Grant No.2023YFC3008404)the Key Laboratory of Earth Fissures Geological Disaster,Ministry of Natural Resources,China(Grant Nos.EFGD20240609 and EFGD20240610).
文摘The recent upsurge in metro construction emphasizes the necessity of understanding the mechanical performance of metro shield tunnel subjected to the influence of ground fissures.In this study,a largescale experiment,in combination with numerical simulation,was conducted to investigate the influence of ground fissures on a metro shield tunnel.The results indicate that the lining contact pressure at the vault increases in the hanging wall while decreases in the footwall,resulting in a two-dimensional stress state of vertical shear and axial tension-compression,and simultaneous vertical dislocation and axial tilt for the segments around the ground fissure.In addition,the damage to curved bolts includes tensile yield,flexural yield,and shear twist,leading to obvious concrete lining damage,particularly at the vault,arch bottom,and hance,indicating that the joints in these positions are weak areas.The shield tunnel orthogonal to the ground fissure ultimately experiences shear failure,suggesting that the maximum actual dislocation of ground fissure that the structure can withstand is approximately 20 cm,and five segment rings in the hanging wall and six segment rings in the footwall also need to be reinforced.This study could provide a reference for metro design in ground fissure sites.
基金financially supported by Shenzhen Science and Technology Program(Nos.JSGG20220831105002005 and KJZD20231025152759002)Support from the National Natural Science Foundation of China(Nos.52374357 and 523B2101)funded by the Shared Voyages Project for Deep-sea and Abyss Scientific Research and Equipment Sea Trials of Hainan Deep-Sea Technology Innovation Center(No.DSTIC-GXHC-2022002)。
文摘Marine gas hydrates are highly sensitive to temperature and pressure fluctuations,and deviations from in-situ conditions may cause irreversible changes in phase state,microstructure,and mechanical properties.However,conventional samplers often fail to maintain sealing and thermal stability,resulting in low sampling success rates.To address these challenges,an in-situ temperature-and pressure-preserved sampler for marine applications has been developed.The experimental results indicate that the selfdeveloped magnetically controlled pressure-preserved controller reliably achieves autonomous triggering and self-sealing,provides an initial sealing force of 83 N,and is capable of maintaining pressures up to 40 MPa.Additionally,a custom-designed intelligent temperature control chip and high-precision sensors were integrated into the sampler.Through the design of an optimized heat transfer structure,a temperature-preserved system was developed,achieving no more than a 0.3℃ rise in temperature within 2 h.The performance evaluation and sampling operations of the sampler were conducted at the Haima Cold Seep in the South China Sea,resulting in the successful recovery of hydrate maintained under in-situ pressure of 13.8 MPa and a temperature of 6.5℃.This advancement enables the acquisition of high-fidelity hydrate samples,providing critical support for the safe exploitation and scientific analysis of marine gas hydrate resources.
基金Supported by the National Key R&D Program of China(2024YFE0114000)Science and Technology Project of China National Petroleum Corporation(2024DJ8702).
文摘Based on the analysis of typical lacustrine shale oil zones in China and their geological characteristics,this study elucidates the fundamental differences between the enrichment patterns of shale oil sweet spots and conventional oil and gas.The key parameters and evaluation methods for assessing the large-scale production potential of lacustrine shale oil are proposed.The results show that shale oil is a petroleum resource that exists in organic-rich shale formations,in other words,it is preserved in its source bed,following a different process of generation-accumulation-enrichment from conventional oil and gas.Thus,the concept of“reservoir”seems to be inapplicable to shale oil.In China,lacustrine shale oil is distributed widely,but the geological characteristics and sweet spots enrichment patterns of shale oil vary significantly in lacustrine basins where the water environment and the tectonic evolution and diagenetic transformation frameworks are distinct.The core of the evaluation of lacustrine shale oil is“sweet spot volume”.The key factors for evaluating the large-scale production of continental shale oil are the oil storage capacity,oil-bearing capacity and oil producing capacity.The key parameters for evaluating these capacities are total porosity,oil content,and free oil content,respectively.It is recommended to determine the total porosity of shale by combining helium porosity measurement with nuclear magnetic resonance(NMR)method,the oil content of key layers by using organic solvent extraction,NMR method and high pressure mercury intrusion methods,and the free oil content by using NMR fluid distribution secondary spectral stripping decomposition and logging.The research results contribute supplemental insights on continental shale oil deliverability in China,and provide a scientific basis for the rapid exploration and large-scale production of lacustrine shale oil.
基金National Natural Science Foundation of China(52375378)National Key Laboratory of Metal Forming Technology and Heavy Equipment(S2308100.W12)Huxiang High-Level Talent Gathering Project of Hunan Province(2021RC5001)。
文摘The titanium alloy strut serves as a key load-bearing component of aircraft landing gear,typically manufactured via forging.The friction condition has important influence on material flow and cavity filling during the forging process.Using the previously optimized shape and initial position of preform,the influence of the friction condition(friction factor m=0.1–0.3)on material flow and cavity filling was studied by numerical method with a shear friction model.A novel filling index was defined to reflect material flow into left and right flashes and zoom in on friction-induced results.The results indicate that the workpiece moves rigidly to the right direction,with the displacement decreasing as m increases.When m<0.18,the underfilling defect will occur in the left side of strut forging,while overflow occurs in the right forging die cavity.By combining the filling index and analyses of material flow and filling status,a reasonable friction factor interval of m=0.21–0.24 can be determined.Within this interval,the cavity filling behavior demonstrates robustness,with friction fluctuations exerting minimal influence.
基金supported by the National Natural Science Foundation of China(Grant No.12272142)Fundamental Research Funds for the Central Universities(Grant No.2172021XXJS048)。
文摘This paper proposes a non-intrusive computational method for mechanical dynamic systems involving a large-scale of interval uncertain parameters,aiming to reduce the computational costs and improve accuracy in determining bounds of system response.The screening method is firstly used to reduce the scale of active uncertain parameters.The sequential high-order polynomials surrogate models are then used to approximate the dynamic system’s response at each time step.To reduce the sampling cost of constructing surrogate model,the interaction effect among uncertain parameters is gradually added to the surrogate model by sequentially incorporating samples from a candidate set,which is composed of vertices and inner grid points.Finally,the points that may produce the bounds of the system response at each time step are searched using the surrogate models.The optimization algorithm is used to locate extreme points,which contribute to determining the inner points producing system response bounds.Additionally,all vertices are also checked using the surrogate models.A vehicle nonlinear dynamic model with 72 uncertain parameters is presented to demonstrate the accuracy and efficiency of the proposed uncertain computational method.
基金supported by grants from the Human Resources Development program(Grant No.20204010600250)the Training Program of CCUS for the Green Growth(Grant No.20214000000500)by the Korea Institute of Energy Technology Evaluation and Planning(KETEP)funded by the Ministry of Trade,Industry,and Energy of the Korean Government(MOTIE).
文摘Three-dimensional printing(3DP)offers valuable insight into the characterization of natural rocks and the verification of theoretical models due to its high reproducibility and accurate replication of complex defects such as cracks and pores.In this study,3DP gypsum samples with different printing directions were subjected to a series of uniaxial compression tests with in situ micro-computed tomography(micro-CT)scanning to quantitatively investigate their mechanical anisotropic properties and damage evolution characteristics.Based on the two-dimensional(2D)CT images obtained at different scanning steps,a novel void ratio variable was derived using the mean value and variance of CT intensity.Additionally,a constitutive model was formulated incorporating the proposed damage variable,utilizing the void ratio variable.The crack evolution and crack morphology of 3DP gypsum samples were obtained and analyzed using the 3D models reconstructed from the CT images.The results indicate that 3DP gypsum samples exhibit mechanical anisotropic characteristics similar to those found in naturally sedimentary rocks.The mechanical anisotropy is attributed to the bedding planes formed between adjacent layers and pillar-like structures along the printing direction formed by CaSO_(4)·2H_(2)O crystals of needle-like morphology.The mean gray intensity of the voids has a positive linear relationship with the threshold value,while the CT variance and void ratio have concave and convex relationships,respectively.The constitutive model can effectively match the stress–strain curves obtained from uniaxial compression experiments.This study provides comprehensive explanations of the failure modes and anisotropic mechanisms of 3DP gypsum samples,which is important for characterizing and understanding the failure mechanism and microstructural evolution of 3DP rocks when modeling natural rock behavior.
基金the Key National Natural Science Foundation of China(No.U1864211)the National Natural Science Foundation of China(No.11772191)the Natural Science Foundation of Shanghai(No.21ZR1431500)。
文摘Industrial data mining usually deals with data from different sources.These heterogeneous datasets describe the same object in different views.However,samples from some of the datasets may be lost.Then the remaining samples do not correspond one-to-one correctly.Mismatched datasets caused by missing samples make the industrial data unavailable for further machine learning.In order to align the mismatched samples,this article presents a cooperative iteration matching method(CIMM)based on the modified dynamic time warping(DTW).The proposed method regards the sequentially accumulated industrial data as the time series.Mismatched samples are aligned by the DTW.In addition,dynamic constraints are applied to the warping distance of the DTW process to make the alignment more efficient.Then a series of models are trained with the cumulated samples iteratively.Several groups of numerical experiments on different missing patterns and missing locations are designed and analyzed to prove the effectiveness and the applicability of the proposed method.
基金Supported by Daqing City Philosophy and Social Sciences Planning Research Project(DSGB 2025011)the Heilongjiang Province Education Science Planning Key Project(GJB1320229).
文摘Based on questionnaire surveys and field interviews conducted with various types of agricultural production organizations across five districts and four counties in Daqing City,this study combines relevant theoretical frameworks to systematically examine the evolution,performance,and influencing factors of governance mechanisms within these organizations.Using both quantitative and inductive analytical methods,the paper proposes innovative designs and supporting measures for improving governance mechanisms.The findings reveal that,amid large-scale farmland circulation,the governance mechanisms of agricultural production organizations in Daqing City are evolving from traditional to modern structures.However,challenges remain in areas such as decision-making efficiency,benefit distribution,and supervision mechanisms.In response,this study proposes innovative governance designs focusing on decision-making processes,profit-sharing mechanisms,and risk prevention.Corresponding policy recommendations are also provided to support the sustainable development of agricultural modernization in China.
基金The Australian Research Council(DP200101197,DP230101107).
文摘Formalizing complex processes and phenomena of a real-world problem may require a large number of variables and constraints,resulting in what is termed a large-scale optimization problem.Nowadays,such large-scale optimization problems are solved using computing machines,leading to an enormous computational time being required,which may delay deriving timely solutions.Decomposition methods,which partition a large-scale optimization problem into lower-dimensional subproblems,represent a key approach to addressing time-efficiency issues.There has been significant progress in both applied mathematics and emerging artificial intelligence approaches on this front.This work aims at providing an overview of the decomposition methods from both the mathematics and computer science points of view.We also remark on the state-of-the-art developments and recent applications of the decomposition methods,and discuss the future research and development perspectives.
